Volume 62 Issue 4 | IOVS

Targeting the YAP/TAZ Pathway in Uveal and Conjunctival Melanoma With Verteporfin Open Access

Niels J. Brouwer; Eleni K. Konstantinou; Evangelos S. Gragoudas; Marina Marinkovic; Gregorius P. M. Luyten; Ivana K. Kim; Martine J. Jager; Demetrios G. Vavvas

Tags: bap1 gene, cell growth, cell lines, genes, malignant melanoma of conjunctiva

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 3. doi:https://doi.org/10.1167/iovs.62.4.3

Coadministration With Carbidopa Enhances the Antimyopic Effects of Levodopa in Chickens Open Access

PDF

Kate Thomson; Ian Morgan; Tamsin Kelly; Cindy Karouta; Regan Ashby

Tags: carbidopa, levodopa, dopamine, myopia

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 25. doi:https://doi.org/10.1167/iovs.62.4.25

Biochemistry and Molecular Biology

Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell–Derived RPE Open Access

PDF

Srinivasa R. Sripathi; Ming-Wen Hu; Melissa M. Liu; Jun Wan; Jie Cheng; Yukan Duan; Joseph L. Mertz; Karl J. Wahlin; Julien Maruotti; Cynthia A. Berlinicke; Jiang Qian; Donald J. Zack

Tags: epithelial to mesenchymal transition, dissociation, tumor necrosis factors, gene expression profiling

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 1. doi:https://doi.org/10.1167/iovs.62.4.1

Clinical and Epidemiologic Research

Correction of Low-Moderate Hyperopia Improves Accommodative Function for Some Hyperopic Children During Sustained Near Work Open Access

PDF

Michael Ntodie; Kathryn J. Saunders; Julie-Anne Little

Tags: child, hyperopia, reading (activity), visual accommodation

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 6. doi:https://doi.org/10.1167/iovs.62.4.6

Rapid Myopic Progression in Childhood Is Associated With Teenage High Myopia Open Access

PDF

Carla Lanca; Li-Lian Foo; Marcus Ang; Chuen-Seng Tan; Biten Kathrani; Hla Myint Htoon; Donald Tan; Quan V. Hoang; Noel Brennan; Seang-Mei Saw; Charumathi Sabanayagam

Tags: adolescent, child, myopia

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 17. doi:https://doi.org/10.1167/iovs.62.4.17

Higher Serum Uric Acid Levels Are Associated With an Increased Risk of Vision-Threatening Diabetic Retinopathy in Type 2 Diabetes Patients Open Access

PDF

Yanan Hu; Zhulin Chan; Chunxia Li; Ya Shi; Xinping She; Chufeng Gu; Yujie Wang; Chuandi Zhou; Shuzhi Zhao; Zhi Zheng; Haibing Chen

Tags: diabetes mellitus, type 2, diabetic retinopathy, hyperuricemia, urate measurement, serum, uric acid

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 23. doi:https://doi.org/10.1167/iovs.62.4.23

Cornea

The Dopaminergic Neuronal System Regulates the Inflammatory Status of Mouse Lacrimal Glands in Dry Eye Disease Open Access

PDF

Yong Woo Ji; Hyun Goo Kang; Jong Suk Song; Ji Won Jun; Kyusun Han; Tae-im Kim; Kyoung Yul Seo; Hyung Keun Lee

Tags: dopamine, dopamine receptors, dry eye syndromes, langer-giedion syndrome, mice

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 14. doi:https://doi.org/10.1167/iovs.62.4.14

IL-36α Exerts Proinflammatory Effects in Aspergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB Open Access

PDF

Yawen Niu; Changjie Ren; Xudong Peng; Cui Li; Qiang Xu; Liting Hu; Ziyue Zhang; Guiqiu Zhao; Jing Lin

Tags: aspergillus fumigatus, cornea, cytokine, keratitis, macrophages

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 16. doi:https://doi.org/10.1167/iovs.62.4.16

Tear Film Cytokine Profile of Patients With the Boston Keratoprosthesis Type 1: Comparing Patients With and Without Glaucoma Open Access

PDF

Dominique Geoffrion; Marie-Claude Robert; Adriana Di Polo; Robert K. Koenekoop; Younes Agoumi; Mona Harissi-Dagher

Tags: cytokine, glaucoma, tear film finding, eye

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 20. doi:https://doi.org/10.1167/iovs.62.4.20

Epigenetic Landscape Analysis of the Long Non-Coding RNA and Messenger RNA in a Mouse Model of Corneal Alkali Burns Open Access

PDF

Li Jiang; Wenjing He; Fen Tang; Ningning Tang; Guangyi Huang; Wei Huang; Xiaonian Wu; Jianpei Guan; Siming Zeng; Min Li; Qi Chen; Mingyuan Zhang; Haibin Zhong; Qianqian Lan; Ling Cui; Lili Li; Fan Xu

Tags: alkalies, burns, cornea, mice, rna

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 28. doi:https://doi.org/10.1167/iovs.62.4.28

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Impact of Amblyopia on Visual Attention and Visual Search in Children Open Access

PDF

Alex A. Black; Joanne M. Wood; Silvie Hoang; Eloise Thomas; Ann L. Webber

Tags: amblyopia, child, visual attention, visual search, vision

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 15. doi:https://doi.org/10.1167/iovs.62.4.15

Multiple Short Daily Periods of Normal Binocular Vision Preserve Stereopsis in Strabismus Open Access

PDF

Janice M. Wensveen; Earl L. Smith, III; Li-Fang Hung; Ronald S. Harwerth

Tags: cercopithecidae, depth perception, prisms, strabismus, vision, binocular

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 27. doi:https://doi.org/10.1167/iovs.62.4.27

Glaucoma

TGF-β2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression Open Access

PDF

Vidhya R. Rao; Evan B. Stubbs, Jr

Tags: nadph oxidase 4, oxidative stress, proteins, trabecular meshwork, nadph oxidases

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 4. doi:https://doi.org/10.1167/iovs.62.4.4

Association Between the Asymmetric Dimethylarginine Levels and Glaucoma Severity: A Cross-Sectional Analysis of the LIGHT Study Open Access

PDF

Tadanobu Yoshikawa; Kenji Obayashi; Kimie Miyata; Keigo Saeki; Nahoko Ogata

Tags: glaucoma, n,n-dimethylarginine, light

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 7. doi:https://doi.org/10.1167/iovs.62.4.7

Longitudinal Observation of Border Tissue Configuration During Axial Elongation in Childhood Open Access

PDF

Yong Woo Kim; Jin Ju Choi; Michael J. A. Girard; Jean Martial Mari; Dong Gyu Choi; Ki Ho Park

Tags: body tissue, child, eye, nose

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 10. doi:https://doi.org/10.1167/iovs.62.4.10

Racial Differences in the Rate of Change in Anterior Lamina Cribrosa Surface Depth in the African Descent and Glaucoma Evaluation Study Open Access

PDF

Christopher A. Girkin; Akram Belghith; Christopher Bowd; Felipe A. Medeiros; Robert N. Weinreb; Jeffrey M. Liebmann; James A. Proudfoot; Linda M. Zangwill; Massimo A. Fazio

Tags: cribriform plate, glaucoma, optic disk, racial differences

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 12. doi:https://doi.org/10.1167/iovs.62.4.12

Posture-Dependent Collapse of the Optic Nerve Subarachnoid Space: A Combined MRI and Modeling Study Open Access

PDF

Petter Holmlund; Karen-Helene Støverud; Anders Wåhlin; Urban Wiklund; Jan Malm; Gauti Jóhannesson; Anders Eklund

Tags: magnetic resonance imaging, optic nerve, posture, subarachnoid space

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 26. doi:https://doi.org/10.1167/iovs.62.4.26

Multidisciplinary Ophthalmic Imaging

Early Identification of Retinal Neuropathy in Subclinical Diabetic Eyes by Reduced Birefringence of the Peripapillary Retinal Nerve Fiber Layer Open Access

PDF

Andreas Pollreisz; Sylvia Desissaire; Aleksandra Sedova; Dorottya Hajdu; Felix Datlinger; Florian Schwarzhans; Stefan Steiner; Irene Steiner; Clemens Vass; Christoph K. Hitzenberger; Michael Pircher; Ursula Schmidt-Erfurth

Tags: birefringence, diabetes mellitus, early diagnosis, eye, neuropathy

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 24. doi:https://doi.org/10.1167/iovs.62.4.24

Retina

Radial Peripapillary Capillary Plexus Sparing and Underlying Retinal Vascular Impairment in Intermediate Age-Related Macular Degeneration Open Access

PDF

Matt Trinh; Michael Kalloniatis; Lisa Nivison-Smith

Tags: age-related macular degeneration, blood capillaries, eye, impairment, maps

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 2. doi:https://doi.org/10.1167/iovs.62.4.2

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage Open Access

PDF

Balasubramaniam Annamalai; Nathaniel Parsons; Crystal Nicholson; Elisabeth Obert; Bryan Jones; Bärbel Rohrer

Tags: complement system proteins, familial hypercholesterolemia, family history, mice, adeno-associated virus

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 11. doi:https://doi.org/10.1167/iovs.62.4.11

Retinal Vessel Functionality Is Linked With ARMS2 A69S and CFH Y402H Polymorphisms and Choroidal Status in AMD Patients Open Access

PDF

Elżbieta Krytkowska; Zofia Ulańczyk; Aleksandra Grabowicz; Katarzyna Mozolewska-Piotrowska; Krzysztof Safranow; Andrzej Pałucha; Mariusz Krawczyk; Piotr Sikora; Ewa Matczyńska; Andreas Stahl; Bogusław Machaliński; Anna Machalińska

Tags: cfh y402h, polymorphism, retinal vessels

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 30. doi:https://doi.org/10.1167/iovs.62.4.30

Volumetric Optical Imaging and Quantitative Analysis of Age-Related Changes in Anterior Human Vitreous Open Access

PDF

Daniel Ruminski; J. Sebag; Raúl Duarte Toledo; Alfonso Jiménez-Villar; Jan K. Nowak; Silvestre Manzanera; Pablo Artal; Ireneusz Grulkowski

Tags: optical imaging, vitreous body, eye, lens, crystalline, reflex, vestibulo-ocular

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 31. doi:https://doi.org/10.1167/iovs.62.4.31

Retinal Cell Biology

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors Open Access

PDF

Yi Chen; Binxin Wu; Jian Feng He; Jingyao Chen; Zi Wei Kang; Dandan Liu; Junjie Luo; Kexin Fang; Xiaoxu Leng; Haibin Tian; Jingying Xu; Caixia Jin; Jieping Zhang; Juan Wang; Jingfa Zhang; Qingjian Ou; Lixia Lu; Furong Gao; Guo-Tong Xu

Tags: epithelial to mesenchymal transition, retinal pigment cell, signal transduction inhibitor, primary eosinophilic endomyocardial cardiomyopathy

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 21. doi:https://doi.org/10.1167/iovs.62.4.21

Visual Neuroscience

Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy Open Access

PDF

Qian Wu; Hao Hu; Wen Chen; Huan-Huan Chen; Lu Chen; Jiang Zhou; Hu Liu; Fei-Yun Wu; Xiao-Quan Xu

Tags: brain, graves' ophthalmopathy

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 5. doi:https://doi.org/10.1167/iovs.62.4.5

Ocular Dominance and Functional Asymmetry in Visual Attention Networks Open Access

PDF

Sinan Liu; Bingyang Zhao; Chaoqun Shi; Xuying Ma; Bernhard A. Sabel; Xiping Chen; Luyang Tao

Tags: attention, eye, ocular dominance, visual attention

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 9. doi:https://doi.org/10.1167/iovs.62.4.9

Light Environment Influences Developmental Programming of the Metabolic and Visual Systems in Mice Open Access

PDF

Danielle A. Clarkson-Townsend; Katie L. Bales; Carmen J. Marsit; Machelle T. Pardue

Tags: body weight, circadian rhythm disorders, mice, visual system, blood glucose

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 22. doi:https://doi.org/10.1167/iovs.62.4.22

Correlations Between Dark-Adapted Rod Threshold Elevations and ERG Response Deficits in Duchenne Muscular Dystrophy Open Access

PDF

Mirella Telles Salgueiro Barboni; Sarah Leonardo Dias; Leonardo Aparecido Silva; Francisco Max Damico; Kallene Summer Vidal; Marcelo Fernandes Costa; Balázs Vince Nagy; Jan Kremers; Dora Fix Ventura

Tags: duchenne's muscular dystrophy, electroretinography, rod photoreceptors, dark adaptation, retinal cone

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 29. doi:https://doi.org/10.1167/iovs.62.4.29

Review

Interleukin-1 and Transforming Growth Factor Beta: Commonly Opposing, but Sometimes Supporting, Master Regulators of the Corneal Wound Healing Response to Injury Open Access

PDF

Steven E. Wilson

Tags: cornea, fibroblasts, interleukin-1, wounds and injuries, myofibroblasts

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 8. doi:https://doi.org/10.1167/iovs.62.4.8

Letters to the Editor

Surface Area of the Exposed Eye Open Access

PDF

Thomas Millar

Tags: eye

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 18. doi:https://doi.org/10.1167/iovs.62.4.18

Author Response: Surface Area of the Exposed Eye Open Access

PDF

Ben J. Glasgow

Tags: eye

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 19. doi:https://doi.org/10.1167/iovs.62.4.19

Erratum

Erratum in: Immunization Against Oxidized Elastin Exacerbates Structural and Functional Damage in Mouse Model of Smoke-Induced Ocular Injury Open Access

PDF

Investigative Ophthalmology & Visual Science April 2021, Vol.62, 13. doi:https://doi.org/10.1167/iovs.62.4.13

This feature is available to authenticated users only.

To View More...

You must be signed into an individual account to use this feature.