Volume 62 Issue 6 | IOVS

Focus on Survival Analysis for Eye Research Open Access

Myra B. McGuinness; Jessica Kasza; Zhichao Wu; Robyn H. Guymer

Tags: eye, survival analysis, lead

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 7. doi:https://doi.org/10.1167/iovs.62.6.7

Setd1a Plays Pivotal Roles for the Survival and Proliferation of Retinal Progenitors via Histone Modifications of Uhrf1 Open Access

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Xiaoyue Deng; Toshiro Iwagawa; Masaya Fukushima; Yutaka Suzuki; Sumiko Watanabe

Tags: apoptosis, histones, plasmids, retina, rna-seq

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 1. doi:https://doi.org/10.1167/iovs.62.6.1

In Vivo Molecular Changes in the Retina of Patients With Multiple Sclerosis Open Access

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Salut Alba-Arbalat; Magi Andorra; Bernardo Sanchez-Dalmau; Anna Camos-Carreras; Marina Dotti-Boada; Irene Pulido-Valdeolivas; Sara Llufriu; Yolanda Blanco; Maria Sepulveda; Albert Saiz; Oscar Batet; Iker Bilbao; Iratxe Torre; Ivan Amat-Roldan; Elena H. Martinez-Lapiscina; Pablo Villoslada

Tags: molecule, multiple sclerosis, retina, spectrum analysis, raman

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 11. doi:https://doi.org/10.1167/iovs.62.6.11

Clinical and Epidemiologic Research

Small Nerve Fiber Damage and Langerhans Cells in Type 1 and Type 2 Diabetes and LADA Measured by Corneal Confocal Microscopy Open Access

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Luca D'Onofrio; Alise Kalteniece; Maryam Ferdousi; Shazli Azmi; Ioannis N. Petropoulos; Georgios Ponirakis; Uazman Alam; Omar Asghar; Andrew Marshall; Andrew J.M. Boulton; Nathan Efron; Raffaella Buzzetti; Handrean Soran; Rayaz A. Malik

Tags: anterior descending branch of left coronary artery, cornea, diabetes mellitus, type 2, langerhans cell, microscopy, confocal

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 5. doi:https://doi.org/10.1167/iovs.62.6.5

Swept-Source OCT Angiographic Characteristics of Treatment-Naïve Nonexudative Macular Neovascularization in AMD Prior to Exudation Open Access

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Mengxi Shen; Qinqin Zhang; Jin Yang; Hao Zhou; Zhongdi Chu; Xiao Zhou; William Feuer; Xiaoshuang Jiang; Yingying Shi; Luis de Sisternes; Mary K. Durbin; Ruikang K. Wang; Giovanni Gregori; Philip J. Rosenfeld

Tags: angiogram, chief complaint, eye, fluid flow, neovascularization, pathologic

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 14. doi:https://doi.org/10.1167/iovs.62.6.14

Cornea

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis Open Access

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Chenyang Dai; Rao Me; Nan Gao; Guanyu Su; Xinyi Wu; Fu-Shin X. Yu

Tags: cornea, keratitis, mice, signal transduction, fungal keratitis

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 10. doi:https://doi.org/10.1167/iovs.62.6.10

Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy Open Access

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Xintian Liu; Shuo Xu; Yingbin Wang; Xin Jin; Yan Shi; Hong Zhang

Tags: atypical, cornea, epithelial cells, eye, herpes zoster ophthalmicus

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 12. doi:https://doi.org/10.1167/iovs.62.6.12

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer Open Access

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James W. Foster; Rupin N. Parikh; Jiangxia Wang; Kraig S. Bower; Mario Matthaei; Shukti Chakravarti; Albert S. Jun; Charles G. Eberhart; Uri S. Soiberman

Tags: epithelium, keratoconus, wnt10a gene, bowman's layer

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 16. doi:https://doi.org/10.1167/iovs.62.6.16

Baicalein Protects Against Aspergillus fumigatus Keratitis by Reducing Fungal Load and Inhibiting TSLP-Induced Inflammatory Response Open Access

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Yunan Zhu; Xudong Peng; Yingxue Zhang; Jing Lin; Guiqiu Zhao

Tags: fungal keratitis, inflammatory response, keratitis, mice, thymic stromal lymphopoietin

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 26. doi:https://doi.org/10.1167/iovs.62.6.26

CLEC-1 Acts as a Negative Regulator of Dectin-1 Induced Host Inflammatory Response Signature in Aspergillus fumigatus Keratitis Open Access

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Guoqiang Zhu; Leyu Lyu; Hua Yang; Jieun Lee; Jintao Sun; Jie Zhang; Shasha Xue; Haijing Yan; Limei Wang; Xiaomeng Chen; Chengye Che

Tags: clec7a gene, keratitis, mice, polymerase chain reaction, aspergillus fumigatus

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 28. doi:https://doi.org/10.1167/iovs.62.6.28

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Cerebral Visual Impairment Characterized by Abnormal Visual Orienting Behavior With Preserved Visual Cortical Activation Open Access

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John P. Kelly; James O. Phillips; Russell P. Saneto; Hedieh Khalatbari; Andrew Poliakov; Kristina Tarczy-Hornoch; Avery H. Weiss

Tags: brain, cortical blindness, evoked potentials, visual, magnetic resonance imaging, pathophysiology

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 15. doi:https://doi.org/10.1167/iovs.62.6.15

Inhibition of Retinal Ganglion Cell Loss By a Novel ROCK Inhibitor (E212) in Ischemic Optic Nerve Injury Via Antioxidative and Anti-Inflammatory Actions Open Access

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Yao-Tseng Wen; Ching-Wen Huang; Chih-Peng Liu; Chih-Hung Chen; Chia-Mu Tu; Chrong-Shiong Hwang; Yi-Hsun Chen; Wan-Ru Chen; Keh-Liang Lin; Yu-Chieh Ho; Ta-Ching Chen; Rong-Kung Tsai

Tags: anti-inflammatory agents, infarction, ischemia, neuroprotective effect, optic nerve injuries

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 21. doi:https://doi.org/10.1167/iovs.62.6.21

Vergence Exercises for Six Weeks Induce Faster Recovery of Convergence Insufficiency Than Accommodation Exercises in School Children Open Access

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Marianne Ledet Maagaard; Ivan Nisted; Toke Bek

Tags: convergence insufficiency, exercise, recovery of function, visual accommodation, child

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 23. doi:https://doi.org/10.1167/iovs.62.6.23

Genetics

Expanding the FDXR-Associated Disease Phenotype: Retinal Dystrophy Is a Recurrent Ocular Feature Open Access

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Neringa Jurkute; Priya D. Shanmugarajah; Marios Hadjivassiliou; Jenny Higgs; Miodrag Vojcic; Iain Horrocks; Yann Nadjar; Valerie Touitou; Guy Lenaers; Roy Poh; James Acheson; Anthony G. Robson; F. Lucy Raymond; Mary M. Reilly; Patrick Yu-Wai-Man; Anthony T. Moore; Andrew R. Webster; Gavin Arno; for the Genomics England Research Consortium

Tags: family, optic atrophy, phenotype, recurrence, retinal dystrophies

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 2. doi:https://doi.org/10.1167/iovs.62.6.2

Phenotypic and Genetic Spectrum of Autosomal Recessive Bestrophinopathy and Best Vitelliform Macular Dystrophy Open Access

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Tyler A. Pfister; Wadih M. Zein; Catherine A. Cukras; Hatice N. Sen; Ramiro S. Maldonado; Laryssa A. Huryn; Robert B. Hufnagel

Tags: autosomal recessive inheritance, bestrophinopathy, genetics, genotype, phenotype

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 22. doi:https://doi.org/10.1167/iovs.62.6.22

Glaucoma

ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice Open Access

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Avani A. Mody; J. Cameron Millar; Abbot F. Clark

Tags: aqueous humor, hypertension, intraocular pressure, mice, ocular hypertension

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 3. doi:https://doi.org/10.1167/iovs.62.6.3

Implanted Microsensor Continuous IOP Telemetry Suggests Gaze and Eyelid Closure Effects on IOP—A Preliminary Study Open Access

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Jacqueline J. O. N. van den Bosch; Vincenzo Pennisi; Azzurra Invernizzi; Kaweh Mansouri; Robert N. Weinreb; Hagen Thieme; Michael B. Hoffmann; Lars Choritz

Tags: eyelid, gaze, intraocular pressure

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 8. doi:https://doi.org/10.1167/iovs.62.6.8

Involvement of c-Jun N-terminal kinase 2 (JNK2) in Endothelin-1 (ET-1) Mediated Neurodegeneration of Retinal Ganglion Cells Open Access

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Bindu Kodati; Dorota L. Stankowska; Vignesh R. Krishnamoorthy; Raghu R. Krishnamoorthy

Tags: endothelin-1, glaucoma, mice, nerve degeneration, neuroprotection

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 13. doi:https://doi.org/10.1167/iovs.62.6.13

Association Between Chronic Renal Disease and the Risk of Glaucoma Development: A 12-year Nationwide Cohort Study Open Access

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Hyun-Kyung Cho; Jong Chul Han; Jin A. Choi; Jae Eun Chae; Rock Bum Kim

Tags: glaucoma, kidney failure, chronic, cohort studies, kidney diseases

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 27. doi:https://doi.org/10.1167/iovs.62.6.27

Retina

Relationship Between Optical Coherence Tomography Parameter and Visual Function in Eyes With Epiretinal Membrane Open Access

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Ayaka Murase; Ryo Asaoka; Tatsuya Inoue; Koichi Nagura; Rei Arasaki; Kentaro Nakamura; Kazuyoshi Okawa; Shin Tanaka; Yasuo Yanagi; Maiko Maruyama-Inoue; Kazuaki Kadonosono

Tags: epiretinal membrane, eye, metamorphopsias, optical coherence tomography, vision

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 6. doi:https://doi.org/10.1167/iovs.62.6.6

Dissecting the Transcriptional and Chromatin Accessibility Heterogeneity of Proliferating Cone Precursors in Human Retinoblastoma Tumors by Single Cell Sequencing—Opening Pathways to New ... Open Access

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Joseph Collin; Rachel Queen; Darin Zerti; David H Steel; Claire Bowen; Manoj Parulekar; Majlinda Lako

Tags: chromatin, neoplasms, retinal cone, retinoblastoma, rna, small cytoplasmic

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 18. doi:https://doi.org/10.1167/iovs.62.6.18

Characterization of PROM1 p.Arg373Cys Variant in a Cohort of Chinese Patients: Macular Dystrophy Plus Peripheral Bone-Spicule Degeneration Open Access

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Yingwei Wang; Panfeng Wang; Shiqiang Li; Jiamin Ouyang; Xiaoyun Jia; Xueshan Xiao; Junxing Yang; Xueqing Li; Wenmin Sun; Qingjiong Zhang

Tags: bone spicule in retina, chinese (other dialects), chinese people, cohort studies, family

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 19. doi:https://doi.org/10.1167/iovs.62.6.19

The Predictive Role of Thyroid Hormone Levels for Early Diabetic Retinal Changes in Experimental Rat and Human Diabetes Open Access

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Anna Énzsöly; Rozina I. Hajdú; Zsolt Turóczi; Irén Szalai; Erika Tátrai; Fanni Pálya; Zoltán Z. Nagy; Csaba Mátyás; Attila Oláh; Tamás Radovits; Klaudia Szabó; Bulcsú Dékány; Arnold Szabó; Ákos Kusnyerik; Petra Soltész; Dániel S. Veres; Anikó Somogyi; Gábor M. Somfai; Ákos Lukáts

Tags: diabetes mellitus, thyroid hormones, retinal cone, retina, opsin

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 20. doi:https://doi.org/10.1167/iovs.62.6.20

Nattokinase Attenuates Retinal Neovascularization Via Modulation of Nrf2/HO-1 and Glial Activation Open Access

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Zijing Huang; Tsz Kin Ng; Weiqi Chen; Xiaowei Sun; Dingguo Huang; Dezhi Zheng; Jingsheng Yi; Yanxuan Xu; Xi Zhuang; Shaolang Chen

Tags: retinal neovascularization, angiogenesis, neovascularization, pathologic, vascular endothelial growth factor a, retina

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 25. doi:https://doi.org/10.1167/iovs.62.6.25

Visual Neuroscience

Correcting QUEST Magnetic Resonance Imaging–Sensitive Free Radical Production in the Outer Retina In Vivo Does Not Correct Reduced Visual Performance in 24-Month-Old C57BL/6J Mice Open Access

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Bruce A. Berkowitz; Robert H. Podolsky; Karen Lins Childers; Robin Roberts; Michael Schneider; Emma Graffice; Kenan Sinan; Ali Berri; Lamis Harp

Tags: free radicals, magnetic resonance imaging, mice, mice, inbred c57bl, retina

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 24. doi:https://doi.org/10.1167/iovs.62.6.24

Visual Psychophysics and Physiological Optics

Dichoptic Perceptual Training in Children With Amblyopia With or Without Patching History Open Access

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Xiang-Yun Liu; Yu-Wei Zhang; Feng Gao; Fei Chen; Jun-Yun Zhang

Tags: amblyopia, child, training, visual acuity, medical history

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 4. doi:https://doi.org/10.1167/iovs.62.6.4

Summation of Temporal L-Cone- and M-Cone-Contrast in the Magno- and Parvocellular Retino-Geniculate Systems in Glaucoma Open Access

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Cord Huchzermeyer; Folkert Horn; Robert Lämmer; Christian Mardin; Jan Kremers

Tags: glaucoma, retinal cone, summation, contrast sensitivity, disease vectors

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 17. doi:https://doi.org/10.1167/iovs.62.6.17

Review

Metabolomics in Glaucoma: A Systematic Review Open Access

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Ying Wang; Xiao-Wen Hou; Gang Liang; Chen-Wei Pan

Tags: glaucoma, metabolomics, metabolites, systematic reviews, biological markers

Investigative Ophthalmology & Visual Science May 2021, Vol.62, 9. doi:https://doi.org/10.1167/iovs.62.6.9

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