Volume 62 Issue 7 | IOVS

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months Open Access

Salma Ferdous; Kristie L. Liao; Isabelle D. Gefke; Vivian R. Summers; Wenfei Wu; Kevin J. Donaldson; Yong-Kyu Kim; Jana T. Sellers; Jendayi A. Dixon; Debresha A. Shelton; Shanu Markand; Somin M. Kim; Nan Zhang; Jeffrey H. Boatright; John M. Nickerson

Tags: eye, mice, mice, inbred c57bl, body weight, photoreceptors

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 9. doi:https://doi.org/10.1167/iovs.62.7.9

Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations Open Access

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Xiaofen Jin; Juanjuan Zhang; Qiuzi Yi; Feilong Meng; Jialing Yu; Yanchun Ji; Jun Q. Mo; Yi Tong; Pingping Jiang; Min-Xin Guan

Tags: mitochondria, mutation, optic atrophy, hereditary, leber, cell lines, proteins

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 22. doi:https://doi.org/10.1167/iovs.62.7.22

Cornea

Ex Vivo–Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice Open Access

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Jun Zhu; Takenori Inomata; Keiichi Fujimoto; Koichiro Uchida; Kenta Fujio; Ken Nagino; Maria Miura; Naoko Negishi; Yuichi Okumura; Yasutsugu Akasaki; Kunihiko Hirosawa; Mizu Kuwahara; Atsuko Eguchi; Hurramhon Shokirova; Ai Yanagawa; Akie Midorikawa-Inomata; Akira Murakami

Tags: cornea, keratoplasty, myeloid-derived suppressor cells, mice, rejection (psychology)

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3. doi:https://doi.org/10.1167/iovs.62.7.3

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium Open Access

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Evan D. Bogdan; Whitney L. Stuard; Rossella Titone; Danielle M. Robertson

Tags: corneal epithelium, homeostasis, hyperosmolality, insulin-like growth factor binding protein 3, sodium chloride

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 11. doi:https://doi.org/10.1167/iovs.62.7.11

PEDF Gene Deletion Disrupts Corneal Innervation and Ocular Surface Function Open Access

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Zhenying Shang; Chenxi Li; Xuemei Liu; Manhong Xu; Xiaomin Zhang; Xiaorong Li; Colin J. Barnstable; Shaozhen Zhao; Joyce Tombran-Tink

Tags: cornea, mice, gene deletion, nerve supply

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 18. doi:https://doi.org/10.1167/iovs.62.7.18

ACE2 Expression Is Upregulated in Inflammatory Corneal Epithelial Cells and Attenuated by Resveratrol Open Access

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Zhixin Jiang; Huan Zhang; Juan Gao; Hao Yu; Ruifang Han; Lin Zhu; Xi Chen; Qian Fan; Peng Hao; Liming Wang; Xuan Li

Tags: attenuation, cornea, corneal epithelial cells, resveratrol, sars-cov-2

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 25. doi:https://doi.org/10.1167/iovs.62.7.25

Inducible Slc4a11 Knockout Triggers Corneal Edema Through Perturbation of Corneal Endothelial Pump Open Access

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Diego G. Ogando; Rajalekshmy Shyam; Edward T. Kim; Yen-Chiao Wang; Chia-Yang Liu; Joseph A. Bonanno

Tags: cornea, corneal edema, endothelium, mice, perturbations

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 28. doi:https://doi.org/10.1167/iovs.62.7.28

Genetics

Characterization of the Spectrum of Ophthalmic Changes in Patients With Alagille Syndrome Open Access

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Mariana Matioli da Palma; Austin D. Igelman; Cristy Ku; Amanda Burr; Jia Yue You; Emily M. Place; Nan-Kai Wang; Jin Kyun Oh; Kari E. Branham; Xinxin Zhang; Jeeyun Ahn; Michael B. Gorin; Byron L. Lam; Cecinio C. Ronquillo; Paul S. Bernstein; Aaron Nagiel; Rachel Huckfeldt; Michelle T. Cabrera; John P. Kelly; Benjamin Bakall; Alessandro Iannaccone; Robert B. Hufnagel; Wadih M. Zein; Robert K. Koenekoop; David G. Birch; Paul Yang; Abigail T. Fahim; Mark E. Pennesi

Tags: arteriohepatic dysplasia, eye

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 27. doi:https://doi.org/10.1167/iovs.62.7.27

Glaucoma

Progression of Primary Angle Closure Suspect to Primary Angle Closure and Associated Risk Factors: The Handan Eye Study Open Access

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Ye Zhang; Ravi Thomas; Qing Zhang; Si Zhen Li; Ning Li Wang

Tags: eye, primary angle closure suspect, risk factors, follow-up

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2. doi:https://doi.org/10.1167/iovs.62.7.2

Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression Open Access

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Shuichiro Aoki; Atsuya Miki; Takashi Omoto; Yuri Fujino; Masato Matsuura; Hiroshi Murata; Ryo Asaoka

Tags: corneal hysteresis, eye, glaucoma, open-angle glaucoma, visual fields

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 4. doi:https://doi.org/10.1167/iovs.62.7.4

Small RNA Sequencing of Aqueous Humor and Plasma in Patients With Primary Open-Angle Glaucoma Open Access

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Wouter H. G. Hubens; Julian Krauskopf; Henny J. M. Beckers; Jos C. S. Kleinjans; Carroll A. B. Webers; Theo G. M. F. Gorgels

Tags: glaucoma, hypertension, micrornas, open-angle glaucoma, plasma

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 24. doi:https://doi.org/10.1167/iovs.62.7.24

Immunology and Microbiology

Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier Open Access

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Jian Liu; Caijiao Yi; Wei Ming; Miao Tang; Xiao Tang; Chang Luo; Bo Lei; Mei Chen; Heping Xu

Tags: muramidase, retinal pigment cell, antimicrobials, peptides

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 21. doi:https://doi.org/10.1167/iovs.62.7.21

Lens

Early Onset of Age-Related Cataracts in Cystine/Glutamate Antiporter Knockout Mice Open Access

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Renita Maria Martis; Bo Li; Paul James Donaldson; Julie Ching-Hsia Lim

Tags: cataract, cystine, lens (device), lens, crystalline, mice

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 23. doi:https://doi.org/10.1167/iovs.62.7.23

Low Vision

Quality of Life and Participation of Children With Visual Impairment: Comparison With Population Reference Scores Open Access

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Ellen B. M. Elsman; Mitchel Koel; Ruth M. A. van Nispen; Ger H. M. B. van Rens

Tags: child, quality of life, visual impairment, parent

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 14. doi:https://doi.org/10.1167/iovs.62.7.14

Physiology and Pharmacology

Acute Inhibitory Effects of Antidepressants on Lacrimal Gland Secretion in the Anesthetized Rat Open Access

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Martin Dankis; Ozgu Aydogdu; Gunnar Tobin; Michael Winder

Tags: antidepressive agents, bodily secretions, lacrimal gland, reflex, tear production

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 8. doi:https://doi.org/10.1167/iovs.62.7.8

Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration Open Access

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John T. Demirs; Junzheng Yang; Maura A. Crowley; Michael Twarog; Omar Delgado; Yubin Qiu; Stephen Poor; Dennis S. Rice; Thaddeus P. Dryja; Karen Anderson; Sha-Mei Liao

Tags: complement system proteins, eye, rna, messenger, age-related macular degeneration, choroid

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 26. doi:https://doi.org/10.1167/iovs.62.7.26

Retina

Expression of the SARS-CoV-2 Receptor ACE2 in Human Retina and Diabetes—Implications for Retinopathy Open Access

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Lingli Zhou; Zhenhua Xu; James Guerra; Avi Z. Rosenberg; Paride Fenaroli; Charles G. Eberhart; Elia J. Duh

Tags: diabetes mellitus, diabetes mellitus, type 2, retina, retinal diseases, sars-cov-2

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 6. doi:https://doi.org/10.1167/iovs.62.7.6

Association of Aberrant Posterior Vitreous Detachment and Pathologic Tractional Forces With Myopic Macular Degeneration Open Access

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Kai Yuan Tey; Qiu Ying Wong; Yee Shan Dan; Andrew S. H. Tsai; Daniel S. W. Ting; Marcus Ang; Gemmy Chiu Ming Cheung; Shu Yen Lee; Tien Yin Wong; Quan V. Hoang; Chee Wai Wong

Tags: eye, myopic macular degeneration, staphyloma, vitreous detachment, traction

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 7. doi:https://doi.org/10.1167/iovs.62.7.7

Anatomic–Functional Correlates in Lesions of Retinal Vein Occlusion Open Access

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Meiaad Khayat; Jennifer Perais; David M. Wright; Michael Williams; Noemi Lois

Tags: eye, retinal ischemia, retinal vein occlusion, ischemia, follow-up

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 10. doi:https://doi.org/10.1167/iovs.62.7.10

The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background Dependent Open Access

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Matthew M. Harper; Nickolas Boehme; Laura M. Dutca; Michael G. Anderson

Tags: basic local alignment search tool, blast injuries, genetic background, genetics, mice

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 13. doi:https://doi.org/10.1167/iovs.62.7.13

North Carolina Macular Dystrophy: Phenotypic Variability and Computational Analysis of Disease-Associated Noncoding Variants Open Access

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David J. Green; Eva Lenassi; Cerys S. Manning; David McGaughey; Vinod Sharma; Graeme C. Black; Jamie M. Ellingford; Panagiotis I. Sergouniotis

Tags: body tissue, datasets, macular dystrophy, phenotype, retina

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 16. doi:https://doi.org/10.1167/iovs.62.7.16

Association Between Gut Microbial Abundance and Sight-Threatening Diabetic Retinopathy Open Access

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Rehana Khan; Abhishek Sharma; Raghul Ravikumar; Avani Parekh; Ramyaa Srinivasan; Ronnie Jacob George; Rajiv Raman

Tags: diabetic retinopathy, dysbiosis, vision, diabetes mellitus, diabetes mellitus, type 2

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 19. doi:https://doi.org/10.1167/iovs.62.7.19

Retinal Cell Biology

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity Open Access

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Jing Zhao; Graydon Gonsalvez; Manuela Bartoli; Barbara A. Mysona; Sylvia B. Smith; Kathryn E. Bollinger

Tags: astrocytes, glial fibrillary acidic protein, optic disk, receptors, sigma, mice

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 5. doi:https://doi.org/10.1167/iovs.62.7.5

Visual Neuroscience

Elavl2 Regulates Retinal Function Via Modulating the Differentiation of Amacrine Cells Subtype Open Access

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Mengjuan Wu; Qinqin Deng; Xinlan Lei; Yuxin Du; Yin Shen

Tags: abdominal compartment syndrome, acute coronary syndromes, amacrine cells, american cancer society, american college of surgeons

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1. doi:https://doi.org/10.1167/iovs.62.7.1

Synaptosomal Actin Dynamics in the Developmental Visual Cortex Regulate Behavioral Visual Acuity in Rats Open Access

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Ai-Ling Bi; Yue-Ying Zhang; Zhi-Yuan Lu; Hong-Ying Tang; Xiu-Yan Zhang; Zi-Han Zhang; Bo-Qin Li; Da-Dong Guo; Sheng Gong; Qian Li; Xing-Rong Wang; Xiu-Zhen Lu; Hong-Sheng Bi

Tags: actins, rats, visual acuity, visual cortex, mitochondria

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 20. doi:https://doi.org/10.1167/iovs.62.7.20

Visual Psychophysics and Physiological Optics

Dichoptic Perceptual Training and Sensory Eye Dominance Plasticity in Normal Vision Open Access

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Ka Yee Kam; Dorita H. F. Chang

Tags: emmetropia, learning, motion, noise, ocular dominance

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 12. doi:https://doi.org/10.1167/iovs.62.7.12

Perspective

Shared Features in Retinal Disorders With Involvement of Retinal Pigment Epithelium Open Access

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Janet R. Sparrow; Rait Parmann; Stephen H. Tsang; Rando Allikmets; Stanley Chang; Ruben Jauregui

Tags: retinal diseases, retinal pigment epithelium, spectral domain-optical coherence tomography, mutation, photoreceptors

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 15. doi:https://doi.org/10.1167/iovs.62.7.15

Erratum

Erratum in: IMI Pathologic Myopia Open Access

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Investigative Ophthalmology & Visual Science June 2021, Vol.62, 17. doi:https://doi.org/10.1167/iovs.62.7.17

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