Volume 62 Issue 9 | IOVS

Editorial

Reviewers Open Access

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Tags: acetylcholine, achondroplasia, barrett's esophagus, calculi, christianity

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 3. doi:https://doi.org/10.1167/iovs.62.9.3

Anatomy and Pathology/Oncology

Primary Cilia in Amacrine Cells in Retinal Development Open Access

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Ke Ning; Brent E. Sendayen; Tia J. Kowal; Biao Wang; Bryan W. Jones; Yang Hu; Yang Sun

Tags: amacrine cells, cilia, mice, retina, pax6 transcription factor

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 15. doi:https://doi.org/10.1167/iovs.62.9.15

Transcriptomic Profiling of Control and Thyroid-Associated Orbitopathy (TAO) Orbital Fat and TAO Orbital Fibroblasts Undergoing Adipogenesis Open Access

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Dong Won Kim; Kamil Taneja; Thanh Hoang; Clayton P. Santiago; Timothy J. McCulley; Shannath L. Merbs; Nicholas R. Mahoney; Seth Blackshaw; Fatemeh Rajaii

Tags: adipocytes, fibroblasts, genes, orbital fat, rna-seq

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 24. doi:https://doi.org/10.1167/iovs.62.9.24

Biochemistry and Molecular Biology

Assocation Between Leber's Hereditary Optic Neuropathy and MT-ND1 3460G>A Mutation-Induced Alterations in Mitochondrial Function, Apoptosis, and Mitophagy Open Access

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Juanjuan Zhang; Yanchun Ji; Jie Chen; Man Xu; Guoping Wang; Xiaorui Ci; Bing Lin; Jun Q. Mo; Xiangtian Zhou; Min-Xin Guan

Tags: apoptosis, cell lines, mitochondria, mutation, optic atrophy, hereditary, leber

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 38. doi:https://doi.org/10.1167/iovs.62.9.38

Clinical and Epidemiologic Research

Environmental and Nutritional Determinants of Macular Pigment in a Mexican Population Open Access

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Marina Green-Gomez; Rachel Moran; James Stringham; Cesar Hernández-Alcaraz; Kenny Mendoza-Herrera; J. Jans Fromow-Guerra; Alfonso Prado-Cabrero; John Nolan

Tags: carotenoids, diet, macular pigment, mexico

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 18. doi:https://doi.org/10.1167/iovs.62.9.18

Serum and Macular Carotenoids in Relation to Retinal Vessel Caliber Fifteen Years Later, in the Second Carotenoids in Age-Related Eye Disease Study Open Access

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Thomas Lawler; Jackson Korger; Yao Liu; Zhe Liu; Jeong W. Pak; Nancy Barrett; Barbara Blodi; Amitha Domalpally; Elizabeth Johnson; Robert Wallace; Julie A. Mares; for the Carotenoids in Age-Related Eye Disease Study Investigators

Tags: carotenoids, eye diseases, retinal vascular caliber

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 20. doi:https://doi.org/10.1167/iovs.62.9.20

Differences in Retinal and Choroidal Vasculature and Perfusion Related to Axial Length in Pediatric Anisomyopes Open Access

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Hao Wu; Zhu Xie; Pengqi Wang; Mengqi Liu; Yuanyuan Wang; Jiadi Zhu; Xiangqin Chen; Zhiqiang Xu; Xinjie Mao; Xiangtian Zhou

Tags: choroidal circulation, myopia, pediatrics, perfusion, vasculature

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 40. doi:https://doi.org/10.1167/iovs.62.9.40

Cornea

Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway Open Access

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Runpu Li; Yingxin Qu; Xiaoqi Li; Ye Tao; Qinghua Yang; Junyi Wang; Yumei Diao; Qian Li; Yifan Fang; Yifei Huang; Liqiang Wang

Tags: chronic exertional compartment syndrome, cornea, oryctolagus cuniculus, hepatorenal syndrome, wounds and injuries

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 2. doi:https://doi.org/10.1167/iovs.62.9.2

The Role of Elastase in Corneal Epithelial Barrier Dysfunction Caused by Pseudomonas aeruginosa Exoproteins Open Access

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Ye Li; YingWei Wang; ChunWei Li; DePeng Zhao; QinYuan Hu; Min Zhou; Miao Du; Jian Li; PengXia Wan

Tags: cornea, elastases, epithelium, pancreatic elastase, chronic exertional compartment syndrome

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 7. doi:https://doi.org/10.1167/iovs.62.9.7

The Role of SREC-Ⅰ in Innate Immunity to Aspergillus fumigatus Keratitis Open Access

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Ranran Zhang; Xudong Peng; Jing Lin; Yingxue Zhang; Lu Zhan; Xue Tian; Jiao Yin; Guiqiu Zhao

Tags: aspergillus fumigatus, fungal keratitis, keratitis, proteins, immunity, natural

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 12. doi:https://doi.org/10.1167/iovs.62.9.12

Human Meibum and Tear Film Derived (O-Acyl)-Omega-Hydroxy Fatty Acids as Biomarkers of Tear Film Dynamics in Meibomian Gland Dysfunction and Dry Eye Disease Open Access

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Safal Khanal; Yuqiang Bai; William Ngo; Kelly K. Nichols; Landon Wilson; Stephen Barnes; Jason J. Nichols

Tags: biological markers, dry eye syndromes, fatty acids, meibomian gland dysfunction, tear film finding

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 13. doi:https://doi.org/10.1167/iovs.62.9.13

Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus Open Access

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Jin-Miao Li; Sangbae Kim; Yun Zhang; Fang Bian; Jiaoyue Hu; Rong Lu; Stephen C. Pflugfelder; Rui Chen; De-Quan Li

Tags: teller acuity cards, trigeminal autonomic cephalalgias, genes, epithelium

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 36. doi:https://doi.org/10.1167/iovs.62.9.36

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis Open Access

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Bo Young Chun; Jong-Heon Kim; Youn-Kwan Jung; Yoon Seok Choi; Gunwoo Kim; Tomoko Yonezawa; Kyoungho Suk

Tags: astrocytes, autoimmunity, mice, optic nerve, optic neuritis

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 8. doi:https://doi.org/10.1167/iovs.62.9.8

Effect of Fibroblast Growth Factor 2 on Extraocular Muscle Structure and Function Open Access

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Jolene C. Rudell; Linda K. McLoon

Tags: fibroblast growth factor 2, fibroblast growth factors, muscle of orbit, muscle, superior rectus muscle

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 34. doi:https://doi.org/10.1167/iovs.62.9.34

Genetics

Myopia in African Americans Is Significantly Linked to Chromosome 7p15.2-14.2 Open Access

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Claire L. Simpson; Anthony M. Musolf; Roberto Y. Cordero; Jennifer B. Cordero; Laura Portas; Federico Murgia; Deyana D. Lewis; Candace D. Middlebrooks; Elise B. Ciner; Joan E. Bailey-Wilson; Dwight Stambolian

Tags: african american, genes, myopia, chromosomes, family

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 16. doi:https://doi.org/10.1167/iovs.62.9.16

Glaucoma

Association of Intereye Visual-Sensitivity Asymmetry With Progression of Primary Open-Angle Glaucoma Open Access

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Eunoo Bak; Young Kook Kim; Ahnul Ha; Young Soo Han; Jin-Soo Kim; Jinho Lee; Yong Woo Kim; Sung Uk Baek; Jin Wook Jeoung; Ki Ho Park

Tags: glaucoma, open-angle glaucoma, visual field defects, eye

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 4. doi:https://doi.org/10.1167/iovs.62.9.4

Longitudinal In Vivo Changes in Retinal Ganglion Cell Dendritic Morphology After Acute and Chronic Optic Nerve Injury Open Access

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Delaney C. M. Henderson; Jayme R. Vianna; John Gobran; Johnny Di Pierdomenico; Michele L. Hooper; Spring R. M. Farrell; Balwantray C. Chauhan

Tags: dendrites, diagnostic imaging, ganglia, glaucoma, language morphology

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 5. doi:https://doi.org/10.1167/iovs.62.9.5

Diabetes Exacerbates the Intraocular Pressure-Independent Retinal Ganglion Cells Degeneration in the DBA/2J Model of Glaucoma Open Access

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Rosario Amato; Francesca Lazzara; Tsung-Han Chou; Giovanni Luca Romano; Maurizio Cammalleri; Massimo Dal Monte; Giovanni Casini; Vittorio Porciatti

Tags: diabetes mellitus, diabetes mellitus, type 2, glaucoma, tissue degeneration, intraocular pressure

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 9. doi:https://doi.org/10.1167/iovs.62.9.9

Neuroprotection of the Inner Retina Also Prevents Secondary Outer Retinal Pathology in a Mouse Model of Glaucoma Open Access

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Sandeep Kumar; Hariharasubramanian Ramakrishnan; Suresh Viswanathan; Abram Akopian; Stewart A. Bloomfield

Tags: glaucoma, mice, retina, neuroprotection, eye

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 35. doi:https://doi.org/10.1167/iovs.62.9.35

Longer Axial Length Potentiates Relationship of Intraocular Pressure and Peripapillary Vessel Density in Glaucoma Patients Open Access

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Joseph Juliano; Bruce Burkemper; Jae Lee; Andrew Nelson; Vivian LeTran; Zhongdi Chu; Gabriella Zhou; Xuejuan Jiang; Ruikang K. Wang; Rohit Varma; Grace M. Richter

Tags: glaucoma, intraocular pressure, peripheral vascular diseases, pulmonary valve disorders

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 37. doi:https://doi.org/10.1167/iovs.62.9.37

Immunology and Microbiology

Distribution of Corneal TRPV1 and Its Association With Immune Cells During Homeostasis and Injury Open Access

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Haihan Jiao; Jason J. Ivanusic; Paul G. McMenamin; Holly R. Chinnery

Tags: cornea, trpv1 receptor, wounds and injuries, neurons

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 6. doi:https://doi.org/10.1167/iovs.62.9.6

Next-Generation HLA Sequence Analysis Uncovers Shared Risk Alleles Between Clinically Distinct Forms of Childhood Uveitis Open Access

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Roos A. W. Wennink; Joke H. de Boer; Sanne Hiddingh; Anne-Mieke J. W. Haasnoot; Viera Kalinina Ayuso; Talitha de Hoop; Jessica van Setten; Eric Spierings; Jonas J. W. Kuiper

Tags: alleles, human leukocyte antigens, uveitis, hla-dqb1, arthritis, juvenile rheumatoid

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 19. doi:https://doi.org/10.1167/iovs.62.9.19

Lens

Age-Dependent Changes in Total and Free Water Content of In Vivo Human Lenses Measured by Magnetic Resonance Imaging Open Access

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Alyssa L. Lie; Xingzheng Pan; Thomas W. White; Ehsan Vaghefi; Paul J. Donaldson

Tags: lens, crystalline, magnetic resonance imaging, water, lens (device), aging

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 33. doi:https://doi.org/10.1167/iovs.62.9.33

Multidisciplinary Ophthalmic Imaging

Evaluation of the Effect of a Novel β3-Adrenergic Agonist on Choroidal Vascularity Open Access

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Murat Topcuoğlu; Fatih Aslan

Tags: agonists, mirabegron

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 17. doi:https://doi.org/10.1167/iovs.62.9.17

Physiology and Pharmacology

Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated Open Access

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Zhen Liu; Yanghui Xiu; Fangfang Qiu; Zhenzhen Zhu; Rongrong Zong; Xiangtian Zhou; Jianhong An; Qiongsi Wang; Peter S Reinach; Wei Li; Wensheng Chen; Zuguo Liu

Tags: myopia, signal transduction

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 21. doi:https://doi.org/10.1167/iovs.62.9.21

Retina

Spectrum of Disease Severity in Nonsyndromic Patients With Mutations in the CEP290 Gene: A Multicentric Longitudinal Study Open Access

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Francesco Testa; Andrea Sodi; Sabrina Signorini; Valentina Di Iorio; Vittoria Murro; Raffaella Brunetti-Pierri; Enza Maria Valente; Marianthi Karali; Paolo Melillo; Sandro Banfi; Francesca Simonelli

Tags: cohort studies, genes, longitudinal studies, mutation, phenotype

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 1. doi:https://doi.org/10.1167/iovs.62.9.1

Early Postnatal Oxygen Exposure Predicts Choroidal Thinning in Neonates Open Access

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Ye He; Moritz Pettenkofer; Muneeswar Gupta Nittala; Srinivas R. Sadda; Irena Tsui; Alison Chu

Tags: infant, infant, premature, newborn, oxygen, birth weight

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 23. doi:https://doi.org/10.1167/iovs.62.9.23

Choroidal and Retinal Thickness and Axial Eye Elongation in Chinese Junior Students Open Access

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Feifei Tian; Deqiang Zheng; Jie Zhang; Lijuan Liu; Jiali Duan; Yin Guo; Youxin Wang; Shuo Wang; Yujian Sang; Xiaoyu Zhang; Weijie Cao; Jinxia Zhang; Ming Sun; Qiuyue Tian; Xiaoni Meng; Xiuhua Guo; Lijuan Wu

Tags: chinese (other dialects), chinese people, eye, student, myopia

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 26. doi:https://doi.org/10.1167/iovs.62.9.26

The Role of Retinal Connexins Cx36 and Horizontal Cell Coupling in Emmetropization in Guinea Pigs Open Access

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Zhina Zhi; Jing Xiang; Qian Fu; Xiaomeng Pei; Dengke Zhou; Yuqing Cao; Liqin Xie; Sen Zhang; Si Chen; Jia Qu; Xiangtian Zhou

Tags: caviidae, gap junction protein, horizontal cells, injections, myopia

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 27. doi:https://doi.org/10.1167/iovs.62.9.27

Hypertensive Retinopathy and the Risk of Stroke Among Hypertensive Adults in China Open Access

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Xuling Chen; Lishun Liu; Mengyi Liu; Xiao Huang; Ying Meng; Haicheng She; Liang Zhao; Jing Zhang; Yadi Zhang; Xiaopeng Gu; Xianhui Qin; Yan Zhang; Jianping Li; Xiping Xu; Binyan Wang; Fan Fan Hou; Genfu Tang; Rongfeng Liao; Yong Huo; Jun Li; Liu Yang

Tags: cerebrovascular accident, china, hypertension, hypertensive retinopathy, ischemic stroke

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 28. doi:https://doi.org/10.1167/iovs.62.9.28

Activated Blood Coagulation Factor X (FXa) Contributes to the Development of Traumatic PVR Through Promoting RPE Epithelial-Mesenchymal Transition Open Access

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Han Han; Xiao Zhao; Mengyu Liao; Yinting Song; Caiyun You; Xue Dong; Xueli Yang; Xiaohong Wang; Bo Huang; Mei Du; Hua Yan

Tags: epithelial to mesenchymal transition, eye, factor x, fibrosis, mice

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 29. doi:https://doi.org/10.1167/iovs.62.9.29

CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy Open Access

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Ahmed M. Abu El-Asrar; Mohd Imtiaz Nawaz; Ajmal Ahmad; Mohammad Mairaj Siddiquei; Eef Allegaert; Priscilla W. Gikandi; Gert De Hertogh; Ghislain Opdenakker

Tags: angiogenesis, biological markers, diabetes mellitus, endothelial cells, enzyme-linked immunosorbent assay

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 32. doi:https://doi.org/10.1167/iovs.62.9.32

Foveal Microvascular Integrity Association With Anti-VEGF Treatment Response for Diabetic Macular Edema Open Access

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Wei-Hsuan Huang; Chi-Chun Lai; Lan-Hsin Chuang; Jerry Chien-Chieh Huang; Cheng-Hsiu Wu; Yu-Tze Lin; Ling Yeung

Tags: anti-vascular endothelial growth factor therapy, diabetic macular edema, personal integrity, injections, eye

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 41. doi:https://doi.org/10.1167/iovs.62.9.41

Retinal Cell Biology

Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138/ROBO4 Axis Open Access

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Xiaoling Shi; Nuo Dong; Qi Qiu; Shanhua Li; Jiaxing Zhang

Tags: hypoxia, wounds and injuries, endothelial cells

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 25. doi:https://doi.org/10.1167/iovs.62.9.25

Optic Nerve Engraftment of Neural Stem Cells Open Access

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Jiun L. Do; Salam Allahwerdy; Ryan Caezar C. David; Robert N. Weinreb; Mark H. Tuszynski; Derek S. Welsbie

Tags: neural stem cells, optic nerve, axon

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 30. doi:https://doi.org/10.1167/iovs.62.9.30

Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction Open Access

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Cristina Escrevente; Ana S. Falcão; Michael J. Hall; Mafalda Lopes-da-Silva; Pedro Antas; Miguel M. Mesquita; Inês S. Ferreira; M. Helena Cardoso; Daniela Oliveira; Ana C. Fradinho; Thomas Ciossek; Paul Nicklin; Clare E. Futter; Sandra Tenreiro; Miguel C. Seabra

Tags: granules, lipofuscin, lysosomes, pathophysiology, retinal pigment epithelium

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 39. doi:https://doi.org/10.1167/iovs.62.9.39

Visual Neuroscience

Responses of Postreceptoral Pathways Elicited by L- and M-Cone Isolating ON- and OFF-Electroretinograms in Glaucoma Patients Open Access

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Avinash J. Aher; Folkert K. Horn; Cord Huchzermeyer; Robert Lämmer; Jan Kremers

Tags: electroretinography, glaucoma, retinal cone

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 14. doi:https://doi.org/10.1167/iovs.62.9.14

Composition of the Inner Nuclear Layer in Human Retina Open Access

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Rania A. Masri; Felix Weltzien; Sivaraman Purushothuman; Sammy C. S. Lee; Paul R. Martin; Ulrike Grünert

Tags: retina, retinal bipolar cells, antibodies, retinal cone

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 22. doi:https://doi.org/10.1167/iovs.62.9.22

Visual Psychophysics and Physiological Optics

Defective Temporal Window of the Foveal Visual Processing in High Myopia Open Access

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Haiyan Zheng; Xiaoxiao Ying; Xianghang He; Jia Qu; Fang Hou

Tags: fovea centralis, myopia, visual processing, perceptual masking, noise

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 11. doi:https://doi.org/10.1167/iovs.62.9.11

The Relationship Between Visual Sensitivity and Eccentricity, Cone Density and Outer Segment Length in the Human Foveola Open Access

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Niklas Domdei; Jenny L. Reiniger; Frank G. Holz; Wolf M. Harmening

Tags: retinal cone

Investigative Ophthalmology & Visual Science July 2021, Vol.62, 31. doi:https://doi.org/10.1167/iovs.62.9.31

Erratum

Erratum in: Quantitative Analysis of Retinal Structure and Function in Two Chromosomally Altered Mouse Models of Down Syndrome Open Access

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Investigative Ophthalmology & Visual Science July 2021, Vol.62, 10. doi:https://doi.org/10.1167/iovs.62.9.10

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