Volume 62 Issue 10 | IOVS

Biochemistry and Molecular Biology

Conjunctival Expression of Toll-Like Receptor 3 Plays a Pathogenic Role in the Formation of Ultraviolet Light–Induced Pterygium Open Access

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Chun-Chieh Lai; Sung-Huei Tseng; Sheng-Min Hsu; Yin-Ting Huang; Chi-Chang Shieh

Tags: conjunctiva, pterygium, toll-like receptor 3, ultraviolet b radiation, pectoral compartment nerve block type 1

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 6. doi:https://doi.org/10.1167/iovs.62.10.6

Clinical and Epidemiologic Research

Fine Particulate Matter and Age-Related Eye Disease: The Canadian Longitudinal Study on Aging Open Access

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Alyssa Grant; Gareth Leung; Marie-Josée Aubin; Marie-Jeanne Kergoat; Gisèle Li; Ellen E. Freeman

Tags: aging, eye diseases, longitudinal studies, particulate matter, glaucoma

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 7. doi:https://doi.org/10.1167/iovs.62.10.7

The Protective Effect of Metformin Use on Early Nd:YAG Laser Capsulotomy Open Access

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Jennifer L. Patnaik; Karen L. Christopher; Michelle G. Pedler; Biehuoy Shieh; Carson C. Petrash; Brandie D. Wagner; Naresh Mandava; Anne M. Lynch; Alan G. Palestine; J. Mark Petrash

Tags: metformin, nd-yag lasers, cohort studies, mice

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 24. doi:https://doi.org/10.1167/iovs.62.10.24

Myopia Progression as a Function of Sex, Age, and Ethnicity Open Access

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Lisa A. Jones-Jordan; Loraine T. Sinnott; Raymond H. Chu; Susan A. Cotter; Robert N. Kleinstein; Ruth E. Manny; Donald O. Mutti; J. Daniel Twelker; Karla Zadnik; for the CLEERE Study Group

Tags: ethnic group, myopia, child

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 36. doi:https://doi.org/10.1167/iovs.62.10.36

COVID-19 Home Quarantine Accelerated the Progression of Myopia in Children Aged 7 to 12 Years in China Open Access

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Mingming Ma; Shuyu Xiong; Shuzhi Zhao; Zhi Zheng; Tao Sun; Chunxia Li

Tags: child, china, coronavirus pandemic, covid-19, myopia

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 37. doi:https://doi.org/10.1167/iovs.62.10.37

Cornea

High-Fat Diet Induces Inflammation of Meibomian Gland Open Access

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Jinghua Bu; Minjie Zhang; Yang Wu; Nan Jiang; Yuli Guo; Xin He; Hui He; M. Vimalin Jeyalatha; Peter Sol Reinach; Zuguo Liu; Wei Li

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 13. doi:https://doi.org/10.1167/iovs.62.10.13

Exploring the Mechanism of the miRNA-145/Paxillin Axis in Cell Metabolism During VEGF-A–Induced Corneal Angiogenesis Open Access

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Wanju Yang; Yanning Yang; Shanshan Wan; Ya Xu; Jing Li; Lu Zhang; Wanruo Guo; Yijun Zheng; Yi Xiang; Yiqiao Xing

Tags: corneal neovascularization, metabolism, vascular endothelial growth factor a, micrornas, angiogenesis

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 25. doi:https://doi.org/10.1167/iovs.62.10.25

Tear Proteomics in Keratoconus: A Quantitative SWATH-MS Analysis Open Access

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Maite López-López; Uxía Regueiro; Susana B. Bravo; María del Pilar Chantada-Vázquez; Rubén Varela-Fernández; Paulo Ávila-Gómez; Pablo Hervella; Isabel Lema

Tags: keratoconus, proteins, proteomics

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 30. doi:https://doi.org/10.1167/iovs.62.10.30

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Velocity Discrimination in Infantile Nystagmus Syndrome Open Access

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Bing Dai; Kwang Meng Cham; Larry Allen Abel

Tags: pathologic nystagmus, syndrome, velocity, gaze

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 35. doi:https://doi.org/10.1167/iovs.62.10.35

Genetics

Phenotypic Consequences of the GJD2 Risk Genotype in Myopia Development Open Access

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Annechien E. G. Haarman; Clair A. Enthoven; Milly S. Tedja; Jan R. Polling; J. Willem L. Tideman; Jan E. E. Keunen; Camiel J. F. Boon; Janine F. Felix; H. Raat; Annette J. M. Geerards; Gregorius P. M. Luyten; Gwyneth A. van Rijn; Virginie J. M. Verhoeven; Caroline C. W. Klaver

Tags: adult, genes, genotype, myopia, phenotype

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 16. doi:https://doi.org/10.1167/iovs.62.10.16

Genotype-Phenotype of Isolated Foveal Hypoplasia in a Large Cohort: Minor Iris Changes as an Indicator of PAX6 Involvement Open Access

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Yi Jiang; Shiqiang Li; Xueshan Xiao; Wenmin Sun; Qingjiong Zhang

Tags: cohort studies, foveal hypoplasia, iris, pathologic nystagmus, pax6 transcription factor

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 23. doi:https://doi.org/10.1167/iovs.62.10.23

Glaucoma

High Pulse Wave Velocity Is Associated With Decreased Macular Vessel Density in Normal-Tension Glaucoma Open Access

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Taekjune Lee; Hyoung Won Bae; Gong Je Seong; Chan Yun Kim; Sang Yeop Lee

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 12. doi:https://doi.org/10.1167/iovs.62.10.12

Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression Open Access

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Heather M. Schmitt; Rachel L. Fehrman; Margaret E. Maes; Huan Yang; Lian-Wang Guo; Cassandra L. Schlamp; Heather R. Pelzel; Robert W. Nickells

Tags: apoptosis, disease susceptibility, immunohistochemistry, mice, neurons

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 14. doi:https://doi.org/10.1167/iovs.62.10.14

Comparison of Optic Nerve Head Microvasculature Between Normal-Tension Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy Open Access

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Ji-Ah Kim; Eun Ji Lee; Tae-Woo Kim; Hee Kyung Yang; Jeong-Min Hwang

Tags: low tension glaucoma, microvascular network, nonarteritic anterior ischemic optic neuropathy, optic disk, eye

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 15. doi:https://doi.org/10.1167/iovs.62.10.15

Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10 Open Access

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Hang-Jing Wu; Douglas P. Mortlock; Rachel W. Kuchtey; John Kuchtey

Tags: fibrillin-2, fibrillins, glaucoma, mice, microfibrils

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 26. doi:https://doi.org/10.1167/iovs.62.10.26

iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma Open Access

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Shangru Sui; Hongxia Yu; Xiangji Wang; Wenyan Wang; Xuejiao Yang; Xiaojing Pan; Qingjun Zhou; Chen Xin; Rong Du; Shen Wu; Jingxue Zhang; Qilong Cao; Ningli Wang; Markus H. Kuehn; Wei Zhu

Tags: cell growth, connexin 43, gap junction protein, glaucoma, medication therapy management

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 28. doi:https://doi.org/10.1167/iovs.62.10.28

Implications of the Relationship Between Refractive Error and Biometry in the Pathogenesis of Primary Angle Closure Open Access

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Kilhwan Shon; Kyung Rim Sung; Joo Young Yoon

Tags: biometry, eye, pathogenesis, refractive errors, cornea

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 38. doi:https://doi.org/10.1167/iovs.62.10.38

Immunology and Microbiology

Understanding the Interactions Between the Ocular Surface Microbiome and the Tear Proteome Open Access

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Denise C. Zysset-Burri; Irina Schlegel; Joel-Benjamin Lincke; Damian Jaggi; Irene Keller; Manfred Heller; Sophie Braga Lagache; Sebastian Wolf; Martin S. Zinkernagel

Tags: microbiome, proteome, comprehension

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 8. doi:https://doi.org/10.1167/iovs.62.10.8

Myeloid Cells in the Mouse Retina and Uveal Tract Respond Differently to Systemic Inflammatory Stimuli Open Access

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Samantha J. Dando; Renee Kazanis; Paul G. McMenamin

Tags: mice, microglia, myeloid cells, retina, uvea

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 10. doi:https://doi.org/10.1167/iovs.62.10.10

Activation of Conjunctiva-Associated Lymphoid Tissue in Patients With Infectious Keratitis Using In Vivo Confocal Microscopy Open Access

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Yuting Liu; Rui Zhu; Xin Jin; Yingbin Wang; Yan Shi; Nan Zhang; Jingrao Wang; Yueyan Dong; Hong Zhang

Tags: keratitis, microscopy, confocal, eye, conjunctiva, lymphoid tissue

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 27. doi:https://doi.org/10.1167/iovs.62.10.27

Dysbiosis in the Gut Microbiome in Streptozotocin-Induced Diabetes Rats and Follow-Up During Retinal Changes Open Access

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Shalem Raj Padakandla; Taraprasad Das; Gumpili Sai Prashanthi; Kiran Kumar Angadi; S. Sreenivasa Reddy; G. Bhanuprakash Reddy; Sisinthy Shivaji

Tags: diabetes mellitus, intestinal bacteria, microbiome, rats, streptozocin

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 31. doi:https://doi.org/10.1167/iovs.62.10.31

Multidisciplinary Ophthalmic Imaging

Diffusion Tensor Imaging of Visual Pathway Abnormalities in Five Glaucoma Animal Models Open Access

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Max K. Colbert; Leon C. Ho; Yolandi van der Merwe; Xiaoling Yang; Gillian J. McLellan; Samuel A. Hurley; Aaron S. Field; Hongmin Yun; Yiqin Du; Ian P. Conner; Carlos Parra; Muneeb A. Faiq; John H. Fingert; Gadi Wollstein; Joel S. Schuman; Kevin C. Chan

Tags: animal model, glaucoma, visual pathways, diffusion tensor imaging

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 21. doi:https://doi.org/10.1167/iovs.62.10.21

Physiology and Pharmacology

Short-Term High Fructose Intake Impairs Diurnal Oscillations in the Murine Cornea Open Access

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Jingxin He; Xinwei Jiao; Xin Sun; Yijia Huang; Pengyang Xu; Yunxia Xue; Ting Fu; Jun Liu; Zhijie Li

Tags: cornea, mice, fructose, rhythm, genes

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 22. doi:https://doi.org/10.1167/iovs.62.10.22

Retina

Retinal Responses to Simulated Optical Blur Using a Novel Dead Leaves ERG Stimulus Open Access

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Athanasios Panorgias; Stephanie Aigbe; Emily Jeong; Carles Otero; Peter J. Bex; Fuensanta A. Vera-Diaz

Tags: electroretinography, optics, photon correlation spectroscopy

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 1. doi:https://doi.org/10.1167/iovs.62.10.1

Macrophage-Like Cell Density Is Increased in Proliferative Diabetic Retinopathy Characterized by Optical Coherence Tomography Angiography Open Access

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Janice X. Ong; Peter L. Nesper; Amani A. Fawzi; Jacob M. Wang; Jeremy A. Lavine

Tags: angiogram, diabetic retinopathy, eye, ischemia, macrophages

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 2. doi:https://doi.org/10.1167/iovs.62.10.2

Ubiquitination-Related miRNA–mRNA Interaction Is a Potential Mechanism in the Progression of Retinoblastoma Open Access

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Xi Chen; Shuilian Chen; Zihua Jiang; Qian Gong; Danni Tang; Qian Luo; Xuan Liu; Shengyu He; Anqi He; Yihui Wu; Jin Qiu; Yan Li; Xiao Wang; Keming Yu; Jing Zhuang

Tags: genes, micrornas, retinoblastoma, rna, messenger, ubiquitination

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 3. doi:https://doi.org/10.1167/iovs.62.10.3

En Face Optical Coherence Tomography Imaging of Foveal Dots in Eyes With Posterior Vitreous Detachment or Internal Limiting Membrane Peeling Open Access

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Cameron Pole; Adrian Au; Eduardo Navajas; K. Bailey Freund; Srinivas Sadda; David Sarraf

Tags: diagnostic imaging, eye, face, fovea centralis, optical coherence tomography

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 5. doi:https://doi.org/10.1167/iovs.62.10.5

Metabolomics Analyses of Mouse Retinas in Oxygen-Induced Retinopathy Open Access

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Yedi Zhou; Wei Tan; Jingling Zou; Jian Cao; Qian Huang; Bing Jiang; Shigeo Yoshida; Yun Li

Tags: metabolites, metabolomics, mice, oxygen, retina

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 9. doi:https://doi.org/10.1167/iovs.62.10.9

Sigma-1R Protects Retinal Ganglion Cells in Optic Nerve Crush Model for Glaucoma Open Access

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Linya Li; Shaoqing He; Yang Liu; Thomas Yorio; Dorette Z. Ellis

Tags: caspase-3, glaucoma, mice, optic nerve, pentazocine

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 17. doi:https://doi.org/10.1167/iovs.62.10.17

Analysis of the Aqueous Humor Proteome in Patients With Age-Related Macular Degeneration Open Access

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Batya Rinsky; Gala Beykin; Michelle Grunin; Radgonde Amer; Samer Khateb; Liran Tiosano; Diego Almeida; Shira Hagbi-Levi; Sarah Elbaz-Hayoun; Itay Chowers

Tags: age-related macular degeneration, aqueous humor, hypertension, proteins, proteome

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 18. doi:https://doi.org/10.1167/iovs.62.10.18

Correlation of Retinal Structure and Visual Function Assessments in Mouse Diabetes Models Open Access

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Sarah R. Sheskey; David A. Antonetti; René C. Rentería; Cheng-Mao Lin

Tags: diabetes mellitus, diabetes mellitus, type 2, mice, visual acuity, vision

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 20. doi:https://doi.org/10.1167/iovs.62.10.20

Inner Macular Changes in Fellow Eye of Patients With Unilateral Idiopathic Epiretinal Membrane Open Access

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Andrea M. Coppe; Giuliana Lapucci; Guido Ripandelli; Francesca R. Pesci; Luca Buzzonetti; Giancarlo Iarossi

Tags: epiretinal membrane, eye, significance, retina

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 29. doi:https://doi.org/10.1167/iovs.62.10.29

Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium Open Access

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Dongfeng Cao; Belinda Leong; Jeffrey D. Messinger; Deepayan Kar; Thomas Ach; Lawrence A. Yannuzzi; K. Bailey Freund; Christine A. Curcio

Tags: age-related macular degeneration, atrophic condition of skin, atrophy, cell transdifferentiation, diagnostic imaging

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 34. doi:https://doi.org/10.1167/iovs.62.10.34

Visual Psychophysics and Physiological Optics

Meridional Anisotropy of Foveal and Peripheral Resolution Acuity in Adults With Emmetropia, Myopia, and Astigmatism Open Access

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Tsz-Wing Leung; Roger W. Li; Chea-Su Kee

Tags: adult, anisotropy, astigmatism, emmetropia, myopia

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 11. doi:https://doi.org/10.1167/iovs.62.10.11

Clinical Trials

Convergence Insufficiency Neuro-Mechanism Adult Population Study: Phoria Adaptation Results Open Access

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Ayushi Sangoi; Mitchell Scheiman; Chang Yaramothu; Elio M. Santos; Suril Gohel; Tara L. Alvarez

Tags: strabismus, convergence insufficiency

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 19. doi:https://doi.org/10.1167/iovs.62.10.19

Review

Metabolomics in Diabetic Retinopathy: A Systematic Review Open Access

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Xiao-Wen Hou; Ying Wang; Chen-Wei Pan

Tags: biological markers, diabetic retinopathy, metabolites, metabolomics, systematic reviews

Investigative Ophthalmology & Visual Science August 2021, Vol.62, 4. doi:https://doi.org/10.1167/iovs.62.10.4

Erratum

Erratum in: Stress Signal Regulation by Na/K-ATPase As a New Approach to Promote Physiological Revascularization in a Mouse Model of Ischemic Retinopathy Open Access

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Investigative Ophthalmology & Visual Science August 2021, Vol.62, 32. doi:https://doi.org/10.1167/iovs.62.10.32

Erratum in: Decreased Vascular Patterning in the Retinas of Astronaut Crew Members as New Measure of Ocular Damage in Spaceflight-Associated Neuro-ocular Syndrome Open Access

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Investigative Ophthalmology & Visual Science August 2021, Vol.62, 33. doi:https://doi.org/10.1167/iovs.62.10.33

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