Volume 62 Issue 12 | IOVS

Anatomy and Pathology/Oncology

Dual Inhibition of Histone Deacetylases and the Mechanistic Target of Rapamycin Promotes Apoptosis in Cell Line Models of Uveal Melanoma Open Access

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Ruchi P. Patel; Joanna R. Thomas; Katherine M. Curt; Christina M. Fitzsimmons; Pedro J. Batista; Susan E. Bates; Michael M. Gottesman; Robert W. Robey

Tags: apoptosis, cell lines, histone deacetylase, mtor inhibitors, mtor serine-threonine kinases

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 16. doi:https://doi.org/10.1167/iovs.62.12.16

Biochemistry and Molecular Biology

The Potential Role of Osteopontin in the Pathogenesis of Graves’ Ophthalmopathy Open Access

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Heng Lou; Lian-Qun Wu; Hao Wang; Rui-Li Wei; Jin-Wei Cheng

Tags: collagen, connective tissue, cytokine, graves' ophthalmopathy, osteopontin

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 18. doi:https://doi.org/10.1167/iovs.62.12.18

Novel Insights Into Muscarinic and Purinergic Responses in Primary Cultures of Rat Lacrimal Gland Myoepithelial Cells Open Access

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Martin Dankis; Thomas Carlsson; Patrik Aronsson; Gunnar Tobin; Michael Winder

Tags: lacrimal gland, muscarinic acetylcholine receptor, patient isolation

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 19. doi:https://doi.org/10.1167/iovs.62.12.19

Effects of Aging on Human Meibum Open Access

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Igor A. Butovich; Tomo Suzuki

Tags: aging, lipids, significance, meibomian gland dysfunction

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 23. doi:https://doi.org/10.1167/iovs.62.12.23

Cornea

Changes in Conjunctival Microbiota Associated With HIV Infection and Antiretroviral Therapy Open Access

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Qun Liu; Zhi-Yi Xu; Xiao-Li Wang; Xiao-Mei Huang; Wen-Lin Zheng; Mei-Jun Li; Fan Xiao; Pei-Wen Ouyang; Xiao-Hua Yang; Yu-Hong Cui; Hong-Wei Pan

Tags: anti-retroviral agents, antiretroviral therapy, highly active, conjunctiva, hiv infections, microbiome

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 1. doi:https://doi.org/10.1167/iovs.62.12.1

Mitochondrial Targeting of the Ammonia-Sensitive Uncoupler SLC4A11 by the Chaperone-Mediated Carrier Pathway in Corneal Endothelium Open Access

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Moonjung Choi; Joseph A. Bonanno

Tags: hsp90 heat-shock proteins, mitochondria, molecular chaperones, ammonia

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 4. doi:https://doi.org/10.1167/iovs.62.12.4

Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy Open Access

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Rajalekshmy Shyam; Diego G. Ogando; Moonjung Choi; Paloma B. Liton; Joseph A. Bonanno

Tags: animal model, autophagy, cornea, endothelial cells, endothelium

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 15. doi:https://doi.org/10.1167/iovs.62.12.15

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Binocular Integration of Perceptually Suppressed Visual Information in Amblyopia Open Access

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Amy Chow; Andrew E. Silva; Katelyn Tsang; Gabriel Ng; Cindy Ho; Benjamin Thompson

Tags: amblyopia, eye, motion

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 11. doi:https://doi.org/10.1167/iovs.62.12.11

Novel Foveal Features Associated With Vision Impairment in Multiple Sclerosis Open Access

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Aubrey Hargrave; Nripun Sredar; Fareshta Khushzad; Jennifer Yarp; Anna Tomczak; May Han; Lucas Kipp; Alfredo Dubra; Heather E. Moss

Tags: diagnostic imaging, eye, multiple sclerosis, visual impairment, retina

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 27. doi:https://doi.org/10.1167/iovs.62.12.27

Glaucoma

U-Shaped Effect of Blood Pressure on Structural OCT Metrics and Retinal Perfusion in Ophthalmologically Healthy Subjects Open Access

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Konstantinos Pappelis; Nomdo M. Jansonius

Tags: blood pressure, glaucoma, homeostasis, hypotension, perfusion

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 5. doi:https://doi.org/10.1167/iovs.62.12.5

The Relationship Between Optic Disc and Retinal Artery Position and Glaucomatous Visual Field Progression Open Access

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Yuri Fujino; Ryo Asaoka; Hiroshi Murata; Takehiro Yamashita

Tags: central retinal artery, glaucoma, intraocular pressure, optic disk, retina

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 6. doi:https://doi.org/10.1167/iovs.62.12.6

Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma Open Access

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Naga Pradeep Rayana; Chenna Kesavulu Sugali; Jiannong Dai; Michael Peng; Shaohui Liu; Yucheng Zhang; Jun Wan; Weiming Mao

Tags: crispr, eye, glaucoma, mice, ocular hypertension

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 7. doi:https://doi.org/10.1167/iovs.62.12.7

Binocular Interactions in Glaucoma Patients With Nonoverlapping Visual Field Defects: Contrast Summation, Rivalry, and Phase Combination Open Access

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Catarina A. R. João; Lorenzo Scanferla; Nomdo M. Jansonius

Tags: eye, glaucoma, summation, vision, visual field defects

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 9. doi:https://doi.org/10.1167/iovs.62.12.9

Immunology and Microbiology

Ocular Surface Microbiota in Diabetic Patients With Dry Eye Disease Open Access

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Zhang Zhang; Xinrong Zou; Wenwen Xue; Pei Zhang; Shanshan Wang; Haidong Zou

Tags: diabetes mellitus, dry eye syndromes, microbiome

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 13. doi:https://doi.org/10.1167/iovs.62.12.13

Lens

Genotype, Age, Genetic Background, and Sex Influence Epha2-Related Cataract Development in Mice Open Access

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Alpana Dave; Jamie E. Craig; Mohammad Alamein; Karina Skrzypiec; Justin Beltz; Annalise Pfaff; Kathryn P. Burdon; Nuran Ercal; Robb U. de Iongh; Shiwani Sharma

Tags: cataract, genetic background, genotype, mice, lens (device)

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 3. doi:https://doi.org/10.1167/iovs.62.12.3

Spatially Resolved Proteomic Analysis of the Lens Extracellular Diffusion Barrier Open Access

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Zhen Wang; Lee S. Cantrell; Kevin L. Schey

Tags: diffusion, lens (device), lens, crystalline, proteins, proteomics

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 25. doi:https://doi.org/10.1167/iovs.62.12.25

Multidisciplinary Ophthalmic Imaging

Impact of Structural Changes on Multifocal Electroretinography in Patients With Use of Hydroxychloroquine Open Access

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Enrico Borrelli; Marco Battista; Maria Lucia Cascavilla; Chiara Viganò; Federico Borghesan; Nicolò Nicolini; Lidia Clemente; Riccardo Sacconi; Costanza Barresi; Alessandro Marchese; Elisabetta Miserocchi; Giulio Modorati; Francesco Bandello; Giuseppe Querques

Tags: electroretinography, hydroxychloroquine, retinal diseases, toxic effect, eye

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 28. doi:https://doi.org/10.1167/iovs.62.12.28

Retina

Progressive Dysmorphia of Retinal Pigment Epithelium in Age-Related Macular Degeneration Investigated by Fluorescence Lifetime Imaging Open Access

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Martin Hammer; Juliane Jakob-Girbig; Linda Schwanengel; Christine A. Curcio; Somar Hasan; Daniel Meller; Rowena Schultz

Tags: age-related macular degeneration, diagnostic imaging, fluorescence, hyperpigmentation, retinal pigment epithelium

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 2. doi:https://doi.org/10.1167/iovs.62.12.2

Oxidative Stress Resistance 1 Gene Therapy Retards Neurodegeneration in the rd1 Mutant Mouse Model of Retinopathy Open Access

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Bhubanananda Sahu; Laura Moreno Leon; Wei Zhang; Nikita Puranik; Ramesh Periasamy; Hemant Khanna; Michael Volkert

Tags: gene therapy, injections, mice, nerve degeneration, oxidative stress

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 8. doi:https://doi.org/10.1167/iovs.62.12.8

Retinal Degeneration Caused by Ago2 Disruption Open Access

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Xue-Jiao Chen; Chang-Jun Zhang; Ya-Han Wang; Zi-Bing Jin

Tags: mice, retina, retinal degeneration, micrornas

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 14. doi:https://doi.org/10.1167/iovs.62.12.14

Impacts of Systemic Hypertension on the Macular Microvasculature in Diabetic Patients Without Clinical Diabetic Retinopathy Open Access

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Min-Woo Lee; Hyung-Moon Koo; Woo-Hyuk Lee; Jae-Hyeong Park; Young-Hoon Lee; Jung-Yeul Kim

Tags: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, hypertension, macular vasculature

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 21. doi:https://doi.org/10.1167/iovs.62.12.21

CD40 Expressed in Endothelial Cells Promotes Upregulation of ICAM-1 But Not Pro-Inflammatory Cytokines, NOS2 and P2X₇ in the Diabetic Retina Open Access

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Jin-Sang Yu; Jad Daw; Jose-Andres C. Portillo; Carlos S. Subauste

Tags: cd40 antigens, diabetes mellitus, endothelial cells, intercellular adhesion molecule 1, retina

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 22. doi:https://doi.org/10.1167/iovs.62.12.22

Vitreous M2 Macrophage-Derived Microparticles Promote RPE Cell Proliferation and Migration in Traumatic Proliferative Vitreoretinopathy Open Access

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Yinting Song; Mengyu Liao; Xiao Zhao; Han Han; Xue Dong; Xiaohong Wang; Mei Du; Hua Yan

Tags: macrophages, massively-parallel genome sequencing, mucopolysaccharidoses, retinal pigment cell, vitreous body

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 26. doi:https://doi.org/10.1167/iovs.62.12.26

Retinal Cell Biology

The Role of the Wnt Pathway in VEGF/Anti-VEGF-Dependent Control of the Endothelial Cell Barrier Open Access

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Yueru Li; Basma Baccouche; Olamide Olayinka; Anara Serikbaeva; Andrius Kazlauskas

Tags: endothelial cells, permeability, vascular endothelial growth factor a, anti-vascular endothelial growth factor therapy, endothelium

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 17. doi:https://doi.org/10.1167/iovs.62.12.17

Visual Neuroscience

The Role of Dopamine in Emmetropization Modulated by Wavelength and Temporal Frequency in Guinea Pigs Open Access

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Tian Tian; Leilei Zou; Shu Wang; Rui Liu; Hong Liu

Tags: 3,4-dihydroxyphenylacetic acid, caviidae, dopamine, vitreous body, cues

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 20. doi:https://doi.org/10.1167/iovs.62.12.20

Visual Psychophysics and Physiological Optics

Balanced Binocular Inputs Support Superior Stereopsis Open Access

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Xi Wang; Alex S. Baldwin; Robert F. Hess

Tags: balance, device, depth perception, equilibrium, eye, imbalance

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 10. doi:https://doi.org/10.1167/iovs.62.12.10

Perspective

Coming of Age for the Photoreceptor Synapse Open Access

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Ellen Townes-Anderson; Eva Halasz; Weiwei Wang; Marco Zarbin

Tags: photoreceptors, retinal cone, retinal detachment, rod photoreceptors, synapses

Investigative Ophthalmology & Visual Science September 2021, Vol.62, 24. doi:https://doi.org/10.1167/iovs.62.12.24

Erratum

Erratum in: Hydrogen Sulfide: A Potential Therapeutic Target in the Development of Diabetic Retinopathy Open Access

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Investigative Ophthalmology & Visual Science September 2021, Vol.62, 12. doi:https://doi.org/10.1167/iovs.62.12.12

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