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Anatomy and Pathology/Oncology

Retinal OFF-Pathway Overstimulation Leads to Greater Accommodation-Induced Choroidal Thinning Open Access
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Hosein Hoseini-Yazdi; Scott A. Read; David Alonso-Caneiro; Michael J. Collins
Tags: visual accommodation, choroid
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 5. doi:https://doi.org/10.1167/iovs.62.13.5
Posterior Vitreous Detachment in Normal Healthy Subjects Younger Than Age Twenty Open Access
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Ayumi Hayashi; Yoko Ito; Yuki Takatsudo; Naoto Hara; Peter L. Gehlbach; Keisuke Mori
Tags: eye, vitreous body, vitreous detachment, diagnostic imaging, retina
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 19. doi:https://doi.org/10.1167/iovs.62.13.19

Cornea

Local Renin-Angiotensin System Activation and Myofibroblast Formation in Graft Versus Host Disease–Associated Conjunctival Fibrosis Open Access
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Kiumars Shamloo; Judy Weng; Christopher Ross; Jenni Lee; Saleh Alfuraih; Jennifer Totonchy; Ajay Sharma
Tags: conjunctiva, fibrosis, graft-versus-host disease, myofibroblasts, renin-angiotensin system
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 10. doi:https://doi.org/10.1167/iovs.62.13.10
Hyperkeratinization and Proinflammatory Cytokine Expression in Meibomian Glands Induced by Staphylococcus aureus Open Access
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Hua Chen; Hui Gao; Hua-Tao Xie; Shu-Ting Liu; Yu-Kan Huang; Ming-Chang Zhang
Tags: cytokine, meibomian gland, mice, staphylococcus aureus, proteins
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 11. doi:https://doi.org/10.1167/iovs.62.13.11
USP10 Promotes Fibronectin Recycling, Secretion, and Organization Open Access
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Andrew T. Phillips; Edward F. Boumil; Nileyma Castro; Arunkumar Venkatesan; Eugenio Gallo; Jarrett J. Adams; Sachdev S. Sidhu; Audrey M. Bernstein
Tags: bodily secretions, dna, complementary, fibronectins, integrins, protein overexpression
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 15. doi:https://doi.org/10.1167/iovs.62.13.15
A Hypothalamic-Controlled Neural Reflex Promotes Corneal Inflammation Open Access
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Romina Mayra Lasagni Vitar; Philippe Fonteyne; Linda Chaabane; Paolo Rama; Giulio Ferrari
Tags: alkalies, burns, cornea, corneal injuries, hypothalamus
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 21. doi:https://doi.org/10.1167/iovs.62.13.21
Establishing an Animal Model of Cytomegalovirus Keratouveitis in Rats: Broad Infection of Anterior Segment Tissue by Cytomegalovirus Open Access
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Shuang Zhang; Yunxiao Zang; Qing Lu; Jiao Ma; Xuan Jiang; Jinghao Qu; Jiaxin Zhang; Rongmei Peng; Minhua Luo; Jing Hong
Tags: animal model, body tissue, cytomegalovirus, infections, rats
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 22. doi:https://doi.org/10.1167/iovs.62.13.22

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Development of Nystagmus With the Absence of MYOD Expression in the Extraocular Muscles Open Access
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Laura L. Johnson; Rachel B. Kueppers; Erin Y. Shen; Jolene C. Rudell; Linda K. McLoon
Tags: mice, muscle of orbit, pathologic nystagmus, muscle
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 3. doi:https://doi.org/10.1167/iovs.62.13.3

Genetics

Genetic Variants Associated With Human Eye Size Are Distinct From Those Conferring Susceptibility to Myopia Open Access
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Denis Plotnikov; Jiangtian Cui; Rosie Clark; Juho Wedenoja; Olavi Pärssinen; J. Willem L. Tideman; Jost B. Jonas; Yaxing Wang; Igor Rudan; Terri L. Young; David A. Mackey; Louise Terry; Cathy Williams; Jeremy A. Guggenheim; for the UK Biobank Eye and Vision Consortium and the CREAM Consortium
Tags: disease susceptibility, eye, genetics, genome-wide association study, myopia
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 24. doi:https://doi.org/10.1167/iovs.62.13.24

Glaucoma

Apolipoprotein E-Containing Lipoproteins and LRP1 Protect From NMDA-Induced Excitotoxicity Associated With Reducing α2-Macroglobulin in Müller Glia Open Access
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Hideki Hayashi; Misuzu Mori; Mina Harashima; Tatsuya Hashizume; Miho Furiya; Chihaya Mukaigaito; Emi Takemura; Mariko Yamada; Kanako Mise; Bo Yuan; Norio Takagi
Tags: excitotoxicity, lipopolysaccharides, macroglobulins, neuroglia, n-methylaspartate
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 23. doi:https://doi.org/10.1167/iovs.62.13.23
Comparative Topographical Analysis of Choroidal Microvascular Dropout Between Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy Open Access
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Eun Jung Lee; Hyun Joo Kee; Kyung-Ah Park; Jong Chul Han; Changwon Kee
Tags: glaucoma, nonarteritic anterior ischemic optic neuropathy, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 27. doi:https://doi.org/10.1167/iovs.62.13.27
Changes in Iris Stiffness and Permeability in Primary Angle Closure Glaucoma Open Access
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Satish K. Panda; Royston K. Y. Tan; Tin A. Tun; Martin L. Buist; Monisha Nongpiur; Mani Baskaran; Tin Aung; Michaël J. A. Girard
Tags: iris, permeability, angle closure glaucoma, body tissue
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 29. doi:https://doi.org/10.1167/iovs.62.13.29

Low Vision

A Unified Rule for Binocular Contrast Summation Applies to Normal Vision and Common Eye Diseases Open Access
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Ying-Zi Xiong; Rong Liu; MiYoung Kwon; Ava K. Bittner; Cynthia Owsley; Gordon E. Legge
Tags: contrast sensitivity, emmetropia, eye diseases, summation, eye
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 6. doi:https://doi.org/10.1167/iovs.62.13.6

Multidisciplinary Ophthalmic Imaging

Cell – Vessel Mismatch in Glaucoma: Correlation of Ganglion Cell Layer Soma and Capillary Densities Open Access
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Ricardo Villanueva; Christopher Le; Zhuolin Liu; Furu Zhang; Laurence Magder; Daniel X Hammer; Osamah Saeedi
Tags: blood capillaries, glaucoma, mismatch, ganglia
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 2. doi:https://doi.org/10.1167/iovs.62.13.2

Physiology and Pharmacology

Effect of Topical Phenylephrine 2.5% on Episcleral Venous Pressure in Normal Human Eyes Open Access
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Arash Kazemi; Jay W. McLaren; Arthur J. Sit
Tags: eye, phenylephrine, venous pressure level, intraocular pressure
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 4. doi:https://doi.org/10.1167/iovs.62.13.4
Influence of Sex on Neuroretinal Degeneration: Six-Month Follow-Up in Rats With Chronic Glaucoma Open Access
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Maria J. Rodrigo; Teresa Martinez-Rincon; Manuel Subias; Silvia Mendez-Martinez; Luis E. Pablo; Vicente Polo; Alba Aragon-Navas; David Garcia-Herranz; Julian García Feijoo; Irene Bravo Osuna; Rocio Herrero-Vanrell; Elena Garcia-Martin
Tags: follow-up, glaucoma, rats, tissue degeneration, sclerosis
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 9. doi:https://doi.org/10.1167/iovs.62.13.9

Retina

Assessment of Detailed Photoreceptor Structure and Retinal Sensitivity in Diabetic Macular Ischemia Using Adaptive Optics-OCT and Microperimetry Open Access
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Felix Datlinger; Lorenz Wassermann; Adrian Reumueller; Dorottya Hajdu; Irene Steiner; Matthias Salas; Wolfgang Drexler; Michael Pircher; Ursula Schmidt-Erfurth; Andreas Pollreisz
Tags: diabetes mellitus, ischemia, language morphology, morphology, optics
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 1. doi:https://doi.org/10.1167/iovs.62.13.1
Localized Structural and Functional Deficits in a Nonhuman Primate Model of Outer Retinal Atrophy Open Access
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Ying V. Liu; Gregory Konar; Kanza Aziz; Sai Bo Bo Tun; Candice Ho Ee Hua; Bingyao Tan; Jing Tian; Chi D. Luu; Veluchamy A. Barathi; Mandeep S. Singh
Tags: eye, lasers, primates, retinal atrophy, electroretinography
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 8. doi:https://doi.org/10.1167/iovs.62.13.8
Location-Specific Thickness Patterns in Intermediate Age-Related Macular Degeneration Reveals Anatomical Differences in Multiple Retinal Layers Open Access
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Matt Trinh; Vincent Khou; Michael Kalloniatis; Lisa Nivison-Smith
Tags: age-related macular degeneration, eye, retinal nerve fiber layer, linear regression
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 13. doi:https://doi.org/10.1167/iovs.62.13.13
A Study of the Association Between Retinal Vessel Geometry and Optical Coherence Tomography Angiography Metrics in Diabetic Retinopathy Open Access
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Ji Min Choi; Seong Mi Kim; Young Hwan Bae; Dae Joong Ma
Tags: angiogram, diabetic retinopathy, optical coherence tomography, retinal vessels
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 14. doi:https://doi.org/10.1167/iovs.62.13.14
Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1+ Macrophage Infiltration Open Access
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Iori Wada; Shintaro Nakao; Muneo Yamaguchi; Yoshihiro Kaizu; Mitsuru Arima; Shinichiro Sawa; Koh-Hei Sonoda
Tags: diabetic retinopathy, lymphangiogenesis, lymphatic vessels, macrophages, mice
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 17. doi:https://doi.org/10.1167/iovs.62.13.17
Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model Open Access
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Tine Van Bergen; Tjing-Tjing Hu; Karis Little; Lies De Groef; Lieve Moons; Alan W. Stitt; Elke Vermassen; Jean H. M. Feyen
Tags: diabetes mellitus, plasma kallikrein, eye, peptides
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 18. doi:https://doi.org/10.1167/iovs.62.13.18
Morphometric and Microstructural Changes During Murine Retinal Development Characterized Using In Vivo Optical Coherence Tomography Open Access
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Simon Brais-Brunet; Émilie Heckel; Udayakumar Kanniyappan; Sylvain Chemtob; Caroline Boudoux; Jean-Sébastien Joyal; Mathieu Dehaes
Tags: diagnostic imaging, mice, optical coherence tomography, retina, optic disk
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 20. doi:https://doi.org/10.1167/iovs.62.13.20
Local Progression Kinetics of Geographic Atrophy Depends Upon the Border Location Open Access
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Liangbo L. Shen; Mengyuan Sun; Aneesha Ahluwalia; Michael M. Park; Benjamin K. Young; Lucian V. Del Priore
Tags: atrophy, base excision repair, eye, growth rate, kinetics
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 28. doi:https://doi.org/10.1167/iovs.62.13.28

Retinal Cell Biology

Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy Open Access
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Emma M. Lessieur; Haitao Liu; Aicha Saadane; Yunpeng Du; Jie Tang; Jianying Kiser; Timothy S. Kern
Tags: cytotoxicity, diabetes mellitus, endopeptidases, endothelial cells, leukocytes
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 7. doi:https://doi.org/10.1167/iovs.62.13.7
Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model Open Access
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You-Ren Wu; Tomoyo Hashiguchi; Junki Sho; Shih-Hwa Chiou; Masayo Takahashi; Michiko Mandai
Tags: embryonic stem cells, mice, n-methylaspartate, retina, retinal ganglion cells
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 26. doi:https://doi.org/10.1167/iovs.62.13.26

Visual Neuroscience

Alertness and Visual Attention Impact Different Aspects of the Optokinetic Reflex Open Access
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Davide Frattini; Tobias Wibble
Tags: consciousness related finding, reflex, visual attention, proxy, attention
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 16. doi:https://doi.org/10.1167/iovs.62.13.16

Visual Psychophysics and Physiological Optics

Luminance Thresholds and Their Correlation With Retinal Structure in X-Linked Retinoschisis Open Access
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J. Jason McAnany; Jason C. Park; Gerald A. Fishman; Robert A. Hyde
Tags: luminance, retina, visual fields, visual thresholds, x-linked retinoschisis
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 25. doi:https://doi.org/10.1167/iovs.62.13.25

New Developments in Vision Research

The Intraocular Pressure Lowering Effect of a Dual Kinase Inhibitor (ITRI-E-(S)4046) in Ocular Hypertensive Animal Models Open Access
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Yi-Hsun Chen; Wan-Ying Lin; Yu Chuan Huang; Wan Yu Ho; Chih-Wei Fu; Chia-Mu Tu; Chrong-Shiong Hwang; Chiu-Lien Hung; Ming-Chun Lin; Felice Cheng; Yen-Jen Wang; Chih-Hung Chen; Shuen-Hsiang Chou; Meng-Ping She; Chia-Yi Yang; Hui-Ling Cheng; Chih-Peng Liu; Da-Wen Lu
Tags: animal model, intraocular pressure, kinase inhibitors, ocular hypertension, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science October 2021, Vol.62, 12. doi:https://doi.org/10.1167/iovs.62.13.12
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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