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Editorial

The 2021 National Eye Institute Strategic Plan: Driving Innovation in Eye and Vision Research Open Access
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Michael F. Chiang
Tags: eye, vision research
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 2. doi:https://doi.org/10.1167/iovs.62.14.2

Anatomy and Pathology/Oncology

Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model Open Access
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Jessica V. Kaczmarek; Carley M. Bogan; Janene M. Pierce; Yuankai K. Tao; Sheau-Chiann Chen; Qi Liu; Xiao Liu; Kelli L. Boyd; M. Wade Calcutt; Thomas M. Bridges; Craig W. Lindsley; Debra L. Friedman; Ann Richmond; Anthony B. Daniels
Tags: belinostat, oryctolagus cuniculus, vitreous body, retinoblastoma, melphalan
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 8. doi:https://doi.org/10.1167/iovs.62.14.8
Genomic Alterations in Human Papillomavirus–Positive and –Negative Conjunctival Squamous Cell Carcinomas Open Access
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Ingvild Ramberg; Filipe Garrett Vieira; Peter Bjerre Toft; Christian von Buchwald; Mikkel Funding; Finn Cilius Nielsen; Steffen Heegaard
Tags: conjunctiva, genome, human papillomavirus, squamous cell carcinoma, carcinoma in situ of conjunctiva
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 11. doi:https://doi.org/10.1167/iovs.62.14.11
Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro Open Access
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Revu V. L. Narayana; Pritikana Jana; Neha Tomar; Varsha Prabhu; Rohini M. Nair; Radhika Manukonda; Swathi Kaliki; Sarah E. Coupland; Jodi Alexander; Helen Kalirai; Anand K. Kondapi; Geeta K. Vemuganti
Tags: cancer stem cells, carboplatin, culture media, conditioned, etoposide, lactoferrin
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 13. doi:https://doi.org/10.1167/iovs.62.14.13

Biochemistry and Molecular Biology

LncRNA NEAT1 Recruits SFPQ to Regulate MITF Splicing and Control RPE Cell Proliferation Open Access
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Xiaojuan Hu; Fang Li; Junhao He; Juan Yang; Ye Jiang; Mingyuan Jiang; Dandan Wei; Lifu Chang; J. Fielding Hejtmancik; Ling Hou; Xiaoyin Ma
Tags: mitf protein, ptb-associated splicing factor, retinal pigment cell, rna splicing, rna, messenger
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 18. doi:https://doi.org/10.1167/iovs.62.14.18
An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice Open Access
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Kristine A. Tsantilas; Whitney M. Cleghorn; Celia M. Bisbach; Jeremy A. Whitson; Daniel T. Hass; Brian M. Robbings; Martin Sadilek; Jonathan D. Linton; Austin M. Rountree; Ana P. Valencia; Mariya T. Sweetwyne; Matthew D. Campbell; Huiliang Zhang; Connor S. R. Jankowski; Ian R. Sweet; David J. Marcinek; Peter S. Rabinovitch; James B. Hurley
Tags: aging, choroid, glucose, metabolic disturbance, mice
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 20. doi:https://doi.org/10.1167/iovs.62.14.20
Conditional Deletion of Cytoplasmic Dynein Heavy Chain in Postnatal Photoreceptors Open Access
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Tiffanie M. Dahl; Michelle Reed; Cecilia D. Gerstner; Wolfgang Baehr
Tags: cytoplasm, dynein atpase, electroretinography, mice, photoreceptors
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 23. doi:https://doi.org/10.1167/iovs.62.14.23

Clinical and Epidemiologic Research

Adiposity by Differing Measures and the Risk of Cataract in the UK Biobank: The Importance of Diabetes Open Access
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Xianwen Shang; Zhuoting Zhu; Xueli Zhang; Yu Huang; Zachary Tan; Wei Wang; Shulin Tang; Zongyuan Ge; Danli Shi; Yu Jiang; Xiaohong Yang; Mingguang He
Tags: cataract, diabetes mellitus, diabetes mellitus, type 2, obesity, biobanks
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 19. doi:https://doi.org/10.1167/iovs.62.14.19
Extrinsic and Intrinsic Factors Regulating Juvenile Refractive Development and Eye Growth Open Access
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Kai Yip Choi; Henry Ho-lung Chan
Tags: child, eye, intrinsic factor, myopia, visual accommodation
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 21. doi:https://doi.org/10.1167/iovs.62.14.21

Cornea

Optogenetic Inhibition of Nav1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain Open Access
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Neal E. Mecum; Rachel Russell; Jun Lee; Cara Sullivan; Ian D. Meng
Tags: cornea, dry eye syndromes, linear gingival erythema, mice, optogenetics
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 15. doi:https://doi.org/10.1167/iovs.62.14.15
Long Noncoding RNA 3632454L22Rik Contributes to Corneal Epithelial Wound Healing by Sponging miR-181a-5p in Diabetic Mice Open Access
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Xiaxue Chen; Jianzhang Hu
Tags: chronic exertional compartment syndrome, cornea, diabetes mellitus, epithelium, mice
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 16. doi:https://doi.org/10.1167/iovs.62.14.16
Role of the Phospholipase C Pathway and Calcium Mobilization in Oxytocin-Induced Contraction of Lacrimal Gland Myoepithelial Cells Open Access
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Angela Gárriz; Salome Aubry; Quentin Wattiaux; Jeffrey Bair; Michael Mariano; Georgios Hatzipetrou; Maytal Bowman; Junji Morokuma; Gustavo Ortiz; Pedram Hamrah; Darlene A. Dartt; Driss Zoukhri
Tags: calcium, lacrimal gland, oxytocin, phospholipase c
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 25. doi:https://doi.org/10.1167/iovs.62.14.25

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Motion Processing Deficits in Children With Cerebral Visual Impairment and Good Visual Acuity Open Access
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Arvind Chandna; Nikolay Nichiporuk; Spero Nicholas; Ram Kumar; Anthony M. Norcia
Tags: child, cortical blindness, harmonics, motion, visual acuity
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 12. doi:https://doi.org/10.1167/iovs.62.14.12

Genetics

ERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers Open Access
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Sahar Gelfman; Dominique Monnet; Ann J. Ligocki; Thierry Tabary; Arden Moscati; Xiaodong Bai; Jan Freudenberg; Blerta Cooper; Jack A. Kosmicki; Sarah Wolf; Manuel A. R. Ferreira; John Overton; Jonathan Weyne; Eli A. Stahl; Aris Baras; Carmelo Romano; Jacques H. M. Cohen; Giovanni Coppola; Antoine Brézin; for the Regeneron Genetics Center
Tags: alleles, human leukocyte antigens, vitiliginous chorioretinitis
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 3. doi:https://doi.org/10.1167/iovs.62.14.3

Glaucoma

Retinal Microcirculatory Responses to Hyperoxia in Primary Open-Angle Glaucoma Using Optical Coherence Tomography Angiography Open Access
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Xintong Fan; Huan Xu; Ruyi Zhai; Qilian Sheng; Xiangmei Kong
Tags: angiogram, hyperoxia, open-angle glaucoma, optical coherence tomography
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 4. doi:https://doi.org/10.1167/iovs.62.14.4
Novel Discoveries of Anterior Segment Parameters in Fellow Eyes of Acute Primary Angle Closure and Chronic Primary Angle Closure Glaucoma Open Access
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Shuqi You; Zhiqiao Liang; Kangyi Yang; Yu Zhang; Julius Oatts; Ying Han; Huijuan Wu
Tags: angle closure glaucoma, eye, ultrasound biomicroscopy, iris, transient ischemic attack
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 6. doi:https://doi.org/10.1167/iovs.62.14.6

Immunology and Microbiology

C-X-C Chemokines Influence Intraocular Inflammation During Bacillus Endophthalmitis Open Access
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Md Huzzatul Mursalin; Phillip S. Coburn; Frederick C. Miller; Erin T. Livingston; Roger Astley; Michelle C. Callegan
Tags: bacillus, cxc chemokines, cxcl2 gene, endophthalmitis, eye
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 14. doi:https://doi.org/10.1167/iovs.62.14.14

Lens

An Atlas of Heparan Sulfate Proteoglycans in the Postnatal Rat Lens Open Access
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Tayler F. L. Wishart; Frank J. Lovicu
Tags: heparan sulfate proteoglycans, lens (device), lens, crystalline, proteins, epithelium
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 5. doi:https://doi.org/10.1167/iovs.62.14.5

Multidisciplinary Ophthalmic Imaging

Ophthalmic Artery Morphological and Hemodynamic Features in Acute Coronary Syndrome Open Access
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Lan-ting Wu; Jia-lin Wang; Yan-ling Wang
Tags: acute coronary syndromes, computed tomographic angiography, hemodynamics, ophthalmic artery, human placental lactogen
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 7. doi:https://doi.org/10.1167/iovs.62.14.7

Retina

Collateral Vessel Development in Central and Branch Retinal Vein Occlusions Are Associated With Worse Visual and Anatomic Outcomes Open Access
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Alessandro Arrigo; Emanuela Aragona; Rosangela Lattanzio; Giovanni Scalia; Francesco Bandello; Maurizio Battaglia Parodi
Tags: eye, retinal vein occlusion, venous retinal branch occlusion, blood capillaries, extension
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 1. doi:https://doi.org/10.1167/iovs.62.14.1
Association of Birth Weight With Foveolar Thickness in Adulthood: Results From a Population-Based Study Open Access
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Achim Fieß; Felix M. Wagner; Michael S. Urschitz; Markus Nagler; Bernhard Stoffelns; Philipp S. Wild; Thomas Münzel; Manfred E. Beutel; Karl J. Lackner; Norbert Pfeiffer; Alexander K. Schuster
Tags: birth weight, adult
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 9. doi:https://doi.org/10.1167/iovs.62.14.9
An In Silica Model for RPE Loss Patterns in Choroideremia Open Access
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Benjamin K. Young; Liangbo L. Shen; Lucian V. Del Priore
Tags: choroideremia, computer simulation, silicon dioxide, atrophy, rod photoreceptors
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 10. doi:https://doi.org/10.1167/iovs.62.14.10
Bulk Gene Expression Deconvolution Reveals Infiltration of M2 Macrophages in Retinal Neovascularization Open Access
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Jiang-Hui Wang; Satheesh Kumar; Guei-Sheung Liu
Tags: gene expression, genes, macrophages, rats, retinal neovascularization
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 22. doi:https://doi.org/10.1167/iovs.62.14.22
Retinal Sensitivity Correlates With the Superficial Vessel Density and Inner Layer Thickness in Diabetic Retinopathy Open Access
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Azzeddine Mokrane; Abir Zureik; Sophie Bonnin; Ali Erginay; Carlo Lavia; Alain Gaudric; Ramin Tadayoni; Aude Couturier
Tags: blood capillaries, diabetes mellitus, diabetic retinopathy, eye, parafoveal region
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 28. doi:https://doi.org/10.1167/iovs.62.14.28

Retinal Cell Biology

Gap Junctional Coupling Between Retinal Astrocytes Exacerbates Neuronal Damage in Ischemia-Reperfusion Injury Open Access
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Abduqodir H. Toychiev; Khulan Batsuuri; Miduturu Srinivas
Tags: astrocytes, connexin 43, gap junction protein, reperfusion injury, retina
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 27. doi:https://doi.org/10.1167/iovs.62.14.27

Visual Psychophysics and Physiological Optics

Perifoveal Cone- and Rod-Mediated Temporal Contrast Sensitivities in Stargardt Disease/Fundus Flavimaculatus Open Access
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Julien Fars; Francesca Pasutto; Jan Kremers; Cord Huchzermeyer
Tags: contrast sensitivity, mandibulofacial dysostosis, photoreceptors, retinal cone, rod photoreceptors
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 24. doi:https://doi.org/10.1167/iovs.62.14.24
Measuring Temporal and Spatial Variability of Red Blood Cell Velocity in Human Retinal Vessels Open Access
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Raymond L. Warner; Thomas J. Gast; Kaitlyn A. Sapoznik; Alessandra Carmichael-Martins; Stephen A. Burns
Tags: blood capillaries, retinal vessels, velocity, photopsia, erythrocytes
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 29. doi:https://doi.org/10.1167/iovs.62.14.29

Perspective

Lowering Intraocular Pressure: A Potential Approach for Controlling High Myopia Progression Open Access
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Peiyuan Wang; Shida Chen; Yaoming Liu; Fengbin Lin; Yunhe Song; Tuozhang Li; Tin Aung; Xiulan Zhang; for the GSHM study group
Tags: intraocular pressure, myopia, sclera
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 17. doi:https://doi.org/10.1167/iovs.62.14.17

Research Opportunities

Report From the National Eye Institute Workshop on Neuro-Ophthalmic Disease Clinical Trial Endpoints: Optic Neuropathies Open Access
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Leonard A. Levin; Mohor Sengupta; Laura J. Balcer; Mark J. Kupersmith; Neil R. Miller
Tags: eye, optic nerve disorders, surrogate endpoints
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 30. doi:https://doi.org/10.1167/iovs.62.14.30

Lecture

Retinal and Choroidal Vascular Diseases: Past, Present, and Future: The 2021 Proctor Lecture Open Access
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Peter A. Campochiaro
Tags: ischemia, pathogenesis, retinal diseases, vascular diseases, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science November 2021, Vol.62, 26. doi:https://doi.org/10.1167/iovs.62.14.26
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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