Select a back issue
Select a back issue
  • Alerts
    User Alerts
    You are adding an alert for:
    Investigative Ophthalmology & Visual Science
    You will receive an email whenever new content is published in the Investigative Ophthalmology & Visual Science. You can manage this and all other alerts in My Account
    The alert will be sent to:
    ×
    This feature is available to authenticated users only.
    Sign In or Create an Account ×

Anatomy and Pathology/Oncology

The Correlations of Macular Structure Characteristics With Idiopathic Epiretinal Membrane and Its Sexual Preference—A Matched Comparison Study Open Access
PDF
I-Hsin Ma; Chung-May Yang; Yi-Ting Hsieh
Tags: comparative study research, epiretinal membrane, eye, sexual orientation
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 10. doi:https://doi.org/10.1167/iovs.63.2.10

Clinical and Epidemiologic Research

Association Between Color Vision Deficiency and Myopia in Chinese Children Over a Five-Year Period Open Access
PDF
Jiahe Gan; Shi-Ming Li; David A. Atchison; Meng-Tian Kang; Shifei Wei; Xi He; Weiling Bai; He Li; Yuting Kang; Zhining Cai; Lei Li; Zi-Bing Jin; Ningli Wang
Tags: child, chinese (other dialects), chinese people, color vision defect, myopia
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 2. doi:https://doi.org/10.1167/iovs.63.2.2
Visual and Refractive Status of Children With Down's Syndrome and Nystagmus Open Access
PDF
Asma A. A. Zahidi; Lee McIlreavy; Jonathan T. Erichsen; J. Margaret Woodhouse
Tags: child, down syndrome, pathologic nystagmus
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 28. doi:https://doi.org/10.1167/iovs.63.2.28

Cornea

The c-Myc Oncogene Maintains Corneal Epithelial Architecture at Homeostasis, Modulates p63 Expression, and Enhances Proliferation During Tissue Repair Open Access
PDF
Céline Portal; Zheng Wang; Donald K. Scott; J. Mario Wolosin; Carlo Iomini
Tags: ablation, c-myc genes, cornea, corneal epithelium, epithelium
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 3. doi:https://doi.org/10.1167/iovs.63.2.3
dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing Open Access
PDF
Xihong Lan; Wang Zhang; Jin Zhu; Huaxing Huang; Kunlun Mo; Huizhen Guo; Liqiong Zhu; Jiafeng Liu; Mingsen Li; Li Wang; Chunqiao Liu; Jianping Ji; Hong Ouyang
Tags: cornea, rna, double-stranded, wound healing, wounds and injuries
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 14. doi:https://doi.org/10.1167/iovs.63.2.14
The Therapeutic Roles of Recombinant Hsp90α on Cornea Epithelial Injury Open Access
PDF
Mingli Wang; Jialin Hu; Junwei Qu; Huili Huang; Jing Zhang; Jun Zhang; Hui Li; Xiukun Cui; Fengyan Zhang; Meng Yue Hu; Jing Li; Yanzhong Hu
Tags: cornea, corneal epithelial cells, epithelium, proteins, wound healing
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 30. doi:https://doi.org/10.1167/iovs.63.2.30
Transmembrane Mucin 1 Blocks Fluorescein Ingress to Corneal Epithelium Open Access
PDF
Yi-Chen Sun; Kai-Feng Hung; Tzu-Yun Li; Yu-An Chang; Po-Ting Yeh; Fung-Rong Hu
Tags: fluorescein, mucins, corneal epithelium, dry eye syndromes
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 31. doi:https://doi.org/10.1167/iovs.63.2.31

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Effect of Viewing Conditions on Fixation Eye Movements and Eye Alignment in Amblyopia Open Access
PDF
Jordan Murray; Palak Gupta; Cody Dulaney; Kiran Garg; Aasef G. Shaikh; Fatema F. Ghasia
Tags: amblyopia, eye, eye movement
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 33. doi:https://doi.org/10.1167/iovs.63.2.33

Genetics

Impact of Next Generation Sequencing in Unraveling the Genetics of 1036 Spanish Families With Inherited Macular Dystrophies Open Access
PDF
Marta Del Pozo-Valero; Rosa Riveiro-Alvarez; Inmaculada Martin-Merida; Fiona Blanco-Kelly; Saoud Swafiri; Isabel Lorda-Sanchez; Maria José Trujillo-Tiebas; Ester Carreño; Belen Jimenez-Rolando; Blanca Garcia-Sandoval; Marta Corton; Almudena Avila-Fernandez; Carmen Ayuso
Tags: abca4 gene, family, genes, genetics, high-throughput nucleotide sequencing
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 11. doi:https://doi.org/10.1167/iovs.63.2.11

Glaucoma

Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration Open Access
PDF
Rafael Lani-Louzada; Camila Marra; Mariana Santana Dias; Victor Guedes de Araújo; Carla Andreia Abreu; Vinícius Toledo Ribas; Daniel Adesse; Silvana Allodi; Vince Chiodo; William Hauswirth; Hilda Petrs-Silva; Rafael Linden
Tags: gene therapy, glaucoma, intravitreal injections, nerve degeneration, optic nerve
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 5. doi:https://doi.org/10.1167/iovs.63.2.5
Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models Open Access
PDF
Uttio Roy Chowdhury; J. Cameron Millar; Bradley H. Holman; Kjersten J. Anderson; Peter I. Dosa; Gavin W. Roddy; Michael P. Fautsch
Tags: animal model, intraocular pressure, mice, ocular hypertension, diazoxide
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 15. doi:https://doi.org/10.1167/iovs.63.2.15
Morphologic Changes in the Lamina Cribrosa Upon Intraocular Pressure Lowering in Patients With Normal Tension Glaucoma Open Access
PDF
Jeong-Ah Kim; Seung Hyen Lee; Dong Hwan Son; Tae-Woo Kim; Eun Ji Lee; Michaël J. A. Girard; Jean Martial Mari
Tags: cribriform plate, intraocular pressure, low tension glaucoma, eye, optic disk
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 23. doi:https://doi.org/10.1167/iovs.63.2.23
The Roles Played by FP/EP3 Receptors During Pressure-lowering in Mouse Eyes Mediated by a Dual FP/EP3 Receptor Agonist Open Access
PDF
Reiko Yamagishi-Kimura; Megumi Honjo; Makoto Aihara
Tags: agonists, eye, intraocular pressure, mice, latanoprost
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 24. doi:https://doi.org/10.1167/iovs.63.2.24

Immunology and Microbiology

Sensory Nerve Retraction and Sympathetic Nerve Innervation Contribute to Immunopathology of Murine Recurrent Herpes Stromal Keratitis Open Access
PDF
Hongmin Yun; Xiao-Tang Yin; Patrick M. Stuart; Anthony J. St. Leger
Tags: cornea, human herpesvirus 1, mice, neurons, recurrence
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 4. doi:https://doi.org/10.1167/iovs.63.2.4
Study of the Correlation Between Severity of Endophthalmitis and Posterior Vitreous Detachment Using a Rabbit Endophthalmitis Model Open Access
PDF
Ryo Baba; Kazuhiko Umazume; Naohito Koike; Hiroshi Goto
Tags: endophthalmitis, oryctolagus cuniculus, vitreous detachment, histopathology tests, retina
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 6. doi:https://doi.org/10.1167/iovs.63.2.6
Enriched and Decreased Intestinal Microbes in Active VKH Patients Open Access
PDF
Mengyao Li; Li Yang; Jinfeng Cao; Tao Liu; Xiaoli Liu
Tags: intestines, microorganisms, anterior scleritis
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 21. doi:https://doi.org/10.1167/iovs.63.2.21

Lens

Analyzing Effect of Waterclefts on Visual Functions Via Optical Simulations Open Access
PDF
Yusuke Seki; Takushi Kawamorita; Naoki Yamamoto; Takashi Tanigawa; Norihiro Mita; Natsuko Hatsusaka; Eri Kubo; Hiroshi Sasaki
Tags: optics, vision, lens, crystalline, eye, shape
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 22. doi:https://doi.org/10.1167/iovs.63.2.22

Retina

Associations Between Peripapillary Retinal Nerve Fiber Layer and Choroidal Thickness With the Development and Progression of Diabetic Retinopathy Open Access
PDF
Xia Gong; Wei Wang; Kun Xiong; Lanhua Wang; Wangting Li; Yuting Li; Meng Yuan; Xiao Guo; Shaochong Zhang; Xiaoling Liang; Hua Liu; Wenyong Huang
Tags: diabetes mellitus, diabetic retinopathy, incidence, nerve degeneration, polychloroterphenyl compounds
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 7. doi:https://doi.org/10.1167/iovs.63.2.7
RPE65-Associated Retinopathies in the Italian Population: A Longitudinal Natural History Study Open Access
PDF
Francesco Testa; Vittoria Murro; Sabrina Signorini; Leonardo Colombo; Giancarlo Iarossi; Francesco Parmeggiani; Benedetto Falsini; Anna Paola Salvetti; Raffaella Brunetti-Pierri; Giorgia Aprile; Chiara Bertone; Agnese Suppiej; Francesco Romano; Marianthi Karali; Simone Donati; Paolo Melillo; Andrea Sodi; Luciano Quaranta; Luca Rossetti; Luca Buzzonetti; Marzio Chizzolini; Stanislao Rizzo; Giovanni Staurenghi; Sandro Banfi; Claudio Azzolini; Francesca Simonelli
Tags: italian, rpe65 protein, cohort studies, retinal diseases, natural history
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 13. doi:https://doi.org/10.1167/iovs.63.2.13
Plasma and Vitreous Metabolomics Profiling of Proliferative Diabetic Retinopathy Open Access
PDF
Hanying Wang; Shu Li; Chingyi Wang; Yihan Wang; Junwei Fang; Kun Liu
Tags: diabetic retinopathy, metabolomics, plasma, proliferative diabetic retinopathy, vitreous body
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 17. doi:https://doi.org/10.1167/iovs.63.2.17
In Vivo Capillary Structure and Blood Cell Flux in the Normal and Diabetic Mouse Eye Open Access
PDF
Kosha Y. Dholakia; Andres Guevara-Torres; Guanping Feng; Derek Power; Jesse Schallek
Tags: blood capillaries, diagnostic imaging, hyperglycemic agents, mice, blood cells
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 18. doi:https://doi.org/10.1167/iovs.63.2.18
OCTA Derived Vessel Skeleton Density Versus Flux and Their Associations With Systemic Determinants of Health Open Access
PDF
Sam Kushner-Lenhoff; Yuandong Li; Qinqin Zhang; Ruikang K. Wang; Xuejuan Jiang; Amir H. Kashani
Tags: diabetes mellitus, health, hematocrit, ventricular septal defect, retinal diseases
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 19. doi:https://doi.org/10.1167/iovs.63.2.19
Choroidal Caverns in Stargardt Disease Open Access
PDF
Dario Pasquale Mucciolo; Dario Giorgio; Myrta Lippera; Valeria Dattilo; Ilaria Passerini; Elisabetta Pelo; Andrea Sodi; Gianni Virgili; Fabrizio Giansanti; Vittoria Murro
Tags: eye, stargardt's disease
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 25. doi:https://doi.org/10.1167/iovs.63.2.25
Spatial Characteristics of Peripheral Visual Islands in Retinitis Pigmentosa Open Access
PDF
Tapan P. Patel; Hursuong Vongsachang; Andrew Schilling; Xiangrong Kong; Mandeep S. Singh
Tags: pulmonary venous flow, retinitis pigmentosa, eye, maps, retina
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 26. doi:https://doi.org/10.1167/iovs.63.2.26
Spatial Dissociation of Subretinal Drusenoid Deposits and Impaired Scotopic and Mesopic Sensitivity in AMD Open Access
PDF
Yuhua Zhang; SriniVas R. Sadda; David Sarraf; Thomas A. Swain; Mark E. Clark; Kenneth R. Sloan; William E. Warriner; Cynthia Owsley; Christine A. Curcio
Tags: digestive tract decontamination, dissociation, drusen, eye, photophobia
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 32. doi:https://doi.org/10.1167/iovs.63.2.32
Choroidal Thickness and Its Association With Age, Axial Length, and Refractive Error in Chinese Adults Open Access
PDF
Jiamin Xie; Luyao Ye; Qiuying Chen; Ya Shi; Guangyi Hu; Yao Yin; Haidong Zou; Jianfeng Zhu; Ying Fan; Jiangnan He; Xun Xu
Tags: adult, chinese (other dialects), chinese people, linear regression, myopia
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 34. doi:https://doi.org/10.1167/iovs.63.2.34

Retinal Cell Biology

Sigma 1 Receptor Contributes to Astrocyte-Mediated Retinal Ganglion Cell Protection Open Access
PDF
Jing Zhao; Graydon B. Gonsalvez; Barbara A. Mysona; Sylvia B. Smith; Kathryn E. Bollinger
Tags: astrocytes, coculture techniques, mice, retinal ganglion cells, patient isolation
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.2.1

Visual Neuroscience

Human Foveal Cone and RPE Cell Topographies and Their Correspondence With Foveal Shape Open Access
PDF
Rigmor C. Baraas; Hilde R. Pedersen; Kenneth Knoblauch; Stuart J. Gilson
Tags: retinal cone, retinal pigment cell, shape
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 8. doi:https://doi.org/10.1167/iovs.63.2.8
Recovery From Form-Deprivation Myopia in Chicks Is Dependent Upon the Fullness and Correlated Color Temperature of the Light Spectrum Open Access
PDF
Arumugam R. Muralidharan; Shermaine W. Y. Low; Yong Chong Lee; Veluchamy A. Barathi; Seang-Mei Saw; Dan Milea; Raymond P. Najjar
Tags: body temperature, eye, myopia, recovery of function, temperature
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 16. doi:https://doi.org/10.1167/iovs.63.2.16
Multi-Contrast Magnetic Resonance Imaging of Visual White Matter Pathways in Patients With Glaucoma Open Access
PDF
Shumpei Ogawa; Hiromasa Takemura; Hiroshi Horiguchi; Atsushi Miyazaki; Kenji Matsumoto; Yoichiro Masuda; Keiji Yoshikawa; Tadashi Nakano
Tags: body tissue, glaucoma, magnetic resonance imaging, white matter
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 29. doi:https://doi.org/10.1167/iovs.63.2.29

Visual Psychophysics and Physiological Optics

Study of the Immediate Effects of Autostereoscopic 3D Visual Training on the Accommodative Functions of Myopes Open Access
PDF
Yangyi Huang; Meiyan Li; Yang Shen; Fang Liu; Yong Fang; Haipeng Xu; Xingtao Zhou
Tags: visual training, training
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 9. doi:https://doi.org/10.1167/iovs.63.2.9
Irissometry: Effects of Pupil Size on Iris Elasticity Measured With Video-Based Feature Tracking Open Access
PDF
Christoph Strauch; Marnix Naber
Tags: iris, pupil size, pupil, elasticity, eye
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 20. doi:https://doi.org/10.1167/iovs.63.2.20
Identifying the Retinal Layers Linked to Human Contrast Sensitivity Via Deep Learning Open Access
PDF
Foroogh Shamsi; Rong Liu; Cynthia Owsley; MiYoung Kwon
Tags: contrast sensitivity, deep learning
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 27. doi:https://doi.org/10.1167/iovs.63.2.27

Perspective

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms Open Access
PDF
Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
Tags: eye, mice, ocular hypertension, intraocular pressure, perfusion
Investigative Ophthalmology & Visual Science February 2022, Vol.63, 12. doi:https://doi.org/10.1167/iovs.63.2.12
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept