Volume 63 Issue 3 | IOVS

Editorial

Reviewers Open Access

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Tags: acetylcholine, achondroplasia, burns, calculi, christianity

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 22. doi:https://doi.org/10.1167/iovs.63.3.22

Anatomy and Pathology/Oncology

Axial Elongation During Short-Term Accommodation in Myopic and Nonmyopic Children Open Access

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Rohan P. J. Hughes; Scott A. Read; Michael J. Collins; Stephen J. Vincent

Tags: child, visual accommodation

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 12. doi:https://doi.org/10.1167/iovs.63.3.12

SP2509, a Selective Inhibitor of LSD1, Suppresses Retinoblastoma Growth by Downregulating β-catenin Signaling Open Access

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Alan Jiang; Weiqi Wu; Caixia Xu; Longbing Mao; Sha Ao; Huifeng Guo; Xiantao Sun; Jing Tao; Yi Sang; Guofu Huang

Tags: cell proliferation, proteins, retinoblastoma, signal transduction, western blotting

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 20. doi:https://doi.org/10.1167/iovs.63.3.20

Biochemistry and Molecular Biology

Intravitreal Injection of PACAP Attenuates Acute Ocular Hypertension–Induced Retinal Injury Via Anti-Apoptosis and Anti-Inflammation in Mice Open Access

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Peng Lu; Yuxun Shi; Dan Ye; Xi Lu; Xiaoyu Tang; Lu Cheng; Yue Xu; Jingjing Huang

Tags: pituitary adenylate cyclase activating polypeptide, retina, wounds and injuries, inflammation, mice

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 18. doi:https://doi.org/10.1167/iovs.63.3.18

Clinical and Epidemiologic Research

Exposure to the Life of a School Child Rather Than Age Determines Myopic Shifts in Refraction in School Children Open Access

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Xiaohu Ding; Ian G. Morgan; Yin Hu; Zhaohui Yuan; Mingguang He

Tags: child, myopia, refraction, school (environment), school-age child

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 15. doi:https://doi.org/10.1167/iovs.63.3.15

Cornea

Obstructive Sleep Apnea Affects Lacrimal Gland Function Open Access

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Shaopan Wang; Xin He; Qingmin Li; Yuhan Zhang; Jiaoyue Hu; Rongrong Zong; Jingyi Zhuang; Andrew J. Quantock; Yingying Gao; Wei Li; Zuguo Liu

Tags: lacrimal gland, mice, obstructive sleep apnea, tear production, lipids

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 3. doi:https://doi.org/10.1167/iovs.63.3.3

Pathogenic Role of Endoplasmic Reticulum Stress in Diabetic Corneal Endothelial Dysfunction Open Access

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Chen Chen; Bin Zhang; Junfa Xue; Zongyi Li; Shengqian Dou; Huilin Chen; Qun Wang; Mingli Qu; Huifeng Wang; Yuan Zhang; Luqin Wan; Qingjun Zhou; Lixin Xie

Tags: cornea, corneal endothelium, diabetes mellitus, endothelial dysfunction, stress

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 4. doi:https://doi.org/10.1167/iovs.63.3.4

Lacrimal Gland Microenvironment Changes After Obstruction of Lacrimal Gland Ducts Open Access

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Xin He; Shaopan Wang; Huimin Sun; Hui He; Yalin Shi; Yiming Wu; Han Wu; Zuguo Liu; Jingyi Zhuang; Wei Li

Tags: lacrimal duct, lacrimal gland, ligation

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 14. doi:https://doi.org/10.1167/iovs.63.3.14

Isotretinoin Impairs the Secretory Function of Meibomian Gland Via the PPARγ Signaling Pathway Open Access

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Peng Zhang; Lei Tian; Jiayu Bao; Shang Li; Ao Li; Ya Wen; Jingyi Wang; Ying Jie

Tags: isotretinoin, meibomian gland, meibomian gland dysfunction

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 29. doi:https://doi.org/10.1167/iovs.63.3.29

Genetics

New COL6A6 Variant Causes Autosomal Dominant Retinitis Pigmentosa in a Four-Generation Family Open Access

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Veronika Vaclavik; Leila Tiab; Young Joo Sun; Vinit B. Mahajan; Alexandre Moulin; Nathalie Allaman-Pillet; Francis L. Munier; Daniel F. Schorderet

Tags: family, retinitis pigmentosa, whole exome sequencing, collagen, immunohistochemistry

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 23. doi:https://doi.org/10.1167/iovs.63.3.23

Glaucoma

Dual Orexin Receptor Antagonist Attenuates Increases in IOP, ICP, and Translaminar Pressure Difference After Stimulation of the Hypothalamus in Rats Open Access

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Arthur A. DeCarlo; Nathan Hammes; Philip L. Johnson; Anantha Shekhar; Brian C. Samuels

Tags: body mass index procedure, hypothalamus, intraocular pressure, orexin receptor antagonists, pefloxacin

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.3.1

Association Between Postillumination Pupil Response and Glaucoma Severity: A Cross-Sectional Analysis of the LIGHT Study Open Access

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Tadanobu Yoshikawa; Kenji Obayashi; Kimie Miyata; Keigo Saeki; Nahoko Ogata

Tags: glaucoma, pupil reaction, light

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 24. doi:https://doi.org/10.1167/iovs.63.3.24

RNA Sequencing of Lens Capsular Epithelium Implicates Novel Pathways in Pseudoexfoliation Syndrome Open Access

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Sean Mullany; Henry Marshall; Tiger Zhou; Daniel Thomson; Joshua M. Schmidt; Ayub Qassim; Lachlan S. W. Knight; Georgina Hollitt; Ella C. Berry; Thi Nguyen; Minh-Son To; David Dimasi; Abraham Kuot; Joshua Dubowsky; Rhys Fogarty; Michelle Sun; Luke Chehade; Shilpa Kuruvilla; Devaraj Supramaniam; James Breen; Shiwani Sharma; John Landers; Stewart Lake; Richard A. Mills; Mark M. Hassall; Weng O. Chan; Sonja Klebe; Emmanuelle Souzeau; Owen M. Siggs; Jamie E. Craig

Tags: genes, lens, crystalline, epithelium, exfoliation syndrome, sequence analysis, rna

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 26. doi:https://doi.org/10.1167/iovs.63.3.26

Parapapillary Choroidal Microvasculature Dropout in Branched Retinal Vein Occlusion and Glaucoma Open Access

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Jiwon Baek; Hae-Young Lopilly Park; Seong Ah Kim; Kyung Euy Hong; Soo Ji Jeon; Da Young Shin; Younhea Jung; Chan Kee Park

Tags: eye, glaucoma, microvascular network, retinal vein occlusion, vaginal intraepithelial neoplasia

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 27. doi:https://doi.org/10.1167/iovs.63.3.27

Systemic Arterial Stiffness Is Associated With Structural Progression in Early Open-Angle Glaucoma Open Access

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Jihei Sara Lee; Hyoung Won Bae; Sungeun Park; Chan Yun Kim; Sang Yeop Lee

Tags: arterial stiffness, open-angle glaucoma, pulse wave velocity

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 28. doi:https://doi.org/10.1167/iovs.63.3.28

Immunology and Microbiology

The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells Open Access

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Andrew R. Griswold; Hsin-Che Huang; Daniel A. Bachovchin

Tags: cornea, corneal epithelial cells, cytokine, inflammasomes, pyroptosis

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 2. doi:https://doi.org/10.1167/iovs.63.3.2

Deciphering the Molecular Signature of Human Hyalocytes in Relation to Other Innate Immune Cell Populations Open Access

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Julian Wolf; Stefaniya Boneva; Dennis-Dominik Rosmus; Hansjürgen Agostini; Günther Schlunck; Peter Wieghofer; Anja Schlecht; Clemens Lange

Tags: genes, microglia, monocytes, sequence analysis, rna, transcription, genetic

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 9. doi:https://doi.org/10.1167/iovs.63.3.9

Antimetabolite Drugs Exhibit Distinctive Immunomodulatory Mechanisms and Effects on the Intestinal Microbiota in Experimental Autoimmune Uveitis Open Access

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Victor Llorenç; Yukiko Nakamura; Christina Metea; Lisa Karstens; Blanca Molins; Phoebe Lin

Tags: antimetabolites, autoimmunity, intestines, mice, microbiome

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 30. doi:https://doi.org/10.1167/iovs.63.3.30

Retina

Evaluation of Local Rod and Cone Function in Stargardt Disease Open Access

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Krunoslav Stingl; Carel Hoyng; Melanie Kempf; Susanne Kohl; Ronja Jung; Giulia Righetti; Laura Kühlewein; Lisa Pohl; Friederike Kortüm; Carina Kelbsch; Barbara Wilhelm; Tobias Peters; Katarina Stingl; on behalf of the SORAPRAZAN consortium

Tags: cardiac progenitor cells, pupil reaction, retinal cone, rod photoreceptors, stargardt's disease

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 6. doi:https://doi.org/10.1167/iovs.63.3.6

LECT2 Ameliorates Blood–Retinal Barrier Impairment Secondary to Diabetes Via Activation of the Tie2/Akt/mTOR Signaling Pathway Open Access

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Yuan-Jun Qin; Ke Xiao; Zheng Zhong; Yin Zhao; Tian Yu; Xu-Fang Sun

Tags: diabetes mellitus, diabetes mellitus, type 2, mtor signaling pathway, proto-oncogene proteins c-akt, retina

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 7. doi:https://doi.org/10.1167/iovs.63.3.7

Aqueous Humor Biomarkers of Retinal Glial Cell Activation in Patients With or Without Age-Related Cataracts and With Different Stages of Diabetic Retinopathy Open Access

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Minjie Zhao; Shuzhi Zhao; Min Tang; Tao Sun; Zhi Zheng; Mingming Ma

Tags: hypertension, biological markers, diabetic retinopathy, neuroglia, aquaporin 1

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 8. doi:https://doi.org/10.1167/iovs.63.3.8

AAV8-Mediated Gene Therapy Rescues Retinal Degeneration Phenotype in a Tlcd3b Knockout Mouse Model Open Access

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Xinye Qian; Hehe Liu; Shangyi Fu; Jiaxiong Lu; Yu-Ting Hung; Cassidy Turner; Haiwei Gu; Rui Chen

Tags: gene therapy, mice, phenotype, photoreceptors, retinal degeneration

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 11. doi:https://doi.org/10.1167/iovs.63.3.11

Functional Correlates of Outer Retina Remodeling in Intermediate Age-Related Macular Degeneration Using Microperimetry Open Access

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Serena Fragiotta; Eliana Costanzo; Pasquale Viggiano; Daniele De Geronimo; Gianluca Scuderi; Monica Varano; Mariacristina Parravano

Tags: age-related macular degeneration, drusen, retina, cortical blindness, eye

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 16. doi:https://doi.org/10.1167/iovs.63.3.16

The RUSH2A Study: Dark-Adapted Visual Fields in Patients With Retinal Degeneration Associated With Biallelic Variants in the USH2A Gene Open Access

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David G. Birch; Lassana Samarakoon; Michele Melia; Jacque L. Duncan; Allison R. Ayala; Isabelle Audo; Janet K. Cheetham; Todd A. Durham; Alessandro Iannaccone; Mark E. Pennesi; Katarina Stingl; for the Foundation Fighting Blindness Consortium Investigator Group

Tags: genes, retinal degeneration, rod photoreceptors, visual fields, illness length

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 17. doi:https://doi.org/10.1167/iovs.63.3.17

Changes in Retinal Optical Coherence Tomography Angiography Indexes Over 24 Hours Open Access

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Barsha Lal; David Alonso-Caneiro; Scott A. Read; Binh Tran; Cong Van Bui; Daniel Tang; Joshua T. Fiedler; Steven Ho; Andrew Carkeet

Tags: angiogram, circadian rhythms, optical coherence tomography, perfusion, parafoveal region

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 25. doi:https://doi.org/10.1167/iovs.63.3.25

Visual Neuroscience

Functional and Structural Development of Mouse Cone Photoreceptor Ribbon Synapses Open Access

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Adam Davison; Kaspar Gierke; Johann Helmut Brandstätter; Norbert Babai

Tags: mice, photoreceptors, retinal cone, synapses

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 21. doi:https://doi.org/10.1167/iovs.63.3.21

Review

The Role of GJD2(Cx36) in Refractive Error Development Open Access

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Emilie van der Sande; Annechien E. G. Haarman; Wim H. Quint; Kirke C. D. Tadema; Magda A. Meester-Smoor; Maarten Kamermans; Chris I. De Zeeuw; Caroline C. W. Klaver; Beerend H. J. Winkelman; Adriana I. Iglesias

Tags: gap junction protein, myopia, refractive errors, retina, amacrine cells

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 5. doi:https://doi.org/10.1167/iovs.63.3.5

Lecture

Nourishing Better Vision: The ARVO 2021 Mildred Weisenfeld Award Lecture Open Access

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Paul S. Bernstein

Tags: awards and prizes, carotenoids, retinoids, science of nutrition, vision

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 13. doi:https://doi.org/10.1167/iovs.63.3.13

Retraction

Retraction Open Access

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Tags: hyperoxia, ophthalmology, skin cancer index, spinal cord injuries, vaccine information sheets

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 10. doi:https://doi.org/10.1167/iovs.63.3.10

Obituary

Remembering Alan M. Laties, MD, 1931–2021 Open Access

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Gustavo D. Aguirre

Investigative Ophthalmology & Visual Science March 2022, Vol.63, 19. doi:https://doi.org/10.1167/iovs.63.3.19

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