Volume 63 Issue 5 | IOVS

High-Fat Nutritional Challenge Reshapes Circadian Signatures in Murine Extraorbital Lacrimal Glands Open Access

Sen Zou; Xinwei Jiao; Jiangman Liu; Di Qi; Xiaoting Pei; Dingli Lu; Shenzhen Huang; Zhijie Li

Tags: circadian rhythms, mice, genes, rhythm, lacrimal gland

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 23. doi:https://doi.org/10.1167/iovs.63.5.23

Scleral Cross-Linking in Form-Deprivation Myopic Guinea Pig Eyes Leads to Glaucomatous Changes Open Access

Lei Guo; Rui Hua; Xinxin Zhang; Ting Yu Yan; Yang Tong; Xin Zhao; Shi Chao Chen; Moying Wang; Neil M. Bressler; Jun Kong

Tags: corneal collagen cross-linking, cross-linking, eye, glaucoma, guinea

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 24. doi:https://doi.org/10.1167/iovs.63.5.24

Biochemistry and Molecular Biology

The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis Open Access

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Fei Luo; Yu Tao; Mengyu Wang; Liuqing Yang; Ruifeng Su; Zhiqiang Pan; Xiaobo Tan

Tags: 1-phosphatidylinositol 3-kinase, mice, phosphoinositide 3-kinase, eye inflammation, protein overexpression

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 4. doi:https://doi.org/10.1167/iovs.63.5.4

Clinical and Epidemiologic Research

Relative Telomere Length Is Associated With Age-Related Macular Degeneration in Women Open Access

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Adriana Koller; Caroline Brandl; Claudia Lamina; Martina E. Zimmermann; Monika Summerer; Klaus J. Stark; Reinhard Würzner; Iris M. Heid; Florian Kronenberg

Tags: age-related macular degeneration, macular degeneration, telomere

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 30. doi:https://doi.org/10.1167/iovs.63.5.30

Statin Use in Relation to Intraocular Pressure, Glaucoma, and Ocular Coherence Tomography Parameters in the UK Biobank Open Access

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Jihye Kim; Marianne T. Kennedy Neary; Hugues Aschard; Mathew M. Palakkamanil; Ron Do; Janey L. Wiggs; Anthony P. Khawaja; Louis R. Pasquale; Jae H. Kang; for the International Glaucoma Genetics Consortium (IGGC), UK Biobank Eye and Vision Consortium, and Modifiable Risk Factors for Glaucoma Collaboration

Tags: biobanks, glaucoma, intraocular pressure, statins

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 31. doi:https://doi.org/10.1167/iovs.63.5.31

Choroidal Thickening During Young Adulthood and Baseline Choroidal Thickness Predicts Refractive Error Change Open Access

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Samantha Sze-Yee Lee; David Alonso-Caneiro; Gareth Lingham; Fred K. Chen; Paul G. Sanfilippo; Seyhan Yazar; David A. Mackey

Tags: adult, choroid, refractive errors

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 34. doi:https://doi.org/10.1167/iovs.63.5.34

Cornea

Limbal Niche Cells and Three-Dimensional Matrigel-Induced Dedifferentiation of Mature Corneal Epithelial Cells Open Access

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Hui Zhu; Wei Wang; Yongyao Tan; Guanyu Su; Lingjuan Xu; Meng lin Jiang; Shen Li; Yaa-Jyuhn James Meir; Yunming Wang; Guigang Li; Huamin Zhou

Tags: anaplasia, corneal epithelial cells, epithelial cells, epithelium, cornea

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.5.1

Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway Open Access

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Ren Liu; Jing Li; Yue Xu; Ziyan Chen; Huijing Ye; Jinhui Tang; Lai Wei; Lingyi Liang

Tags: cytokine, epithelial cells, lipogenesis, meibomian gland, melatonin

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 6. doi:https://doi.org/10.1167/iovs.63.5.6

Shotgun Proteomics for the Identification and Profiling of the Tear Proteome of Keratoconus Patients Open Access

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Maite López-López; Uxía Regueiro; Susana Belén Bravo; María del Pilar Chantada-Vázquez; Carmen Pena; Elío Díez-Feijoo; Pablo Hervella; Isabel Lema

Tags: keratoconus, proteins, proteome, proteomics, enzyme-linked immunosorbent assay

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 12. doi:https://doi.org/10.1167/iovs.63.5.12

Comprehensive Analysis Identified the Circadian Clock and Global Circadian Gene Expression in Human Corneal Endothelial Cells Open Access

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Hiroko Nakai; Yoshiki Tsuchiya; Nobuya Koike; Taiki Asano; Morio Ueno; Yasuhiro Umemura; Yuh Sasawaki; Ryutaro Ono; Junji Hamuro; Chie Sotozono; Kazuhiro Yagita

Tags: circadian clocks, cornea, endothelial cells, gene expression, chronic exertional compartment syndrome

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 16. doi:https://doi.org/10.1167/iovs.63.5.16

Genetics

Central Visual Function and Genotype–Phenotype Correlations in PDE6A-Associated Retinitis Pigmentosa Open Access

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Laura Kuehlewein; Torsten Straßer; Gunnar Blumenstock; Katarina Stingl; M. Dominik Fischer; Barbara Wilhelm; Eberhart Zrenner; Bernd Wissinger; Susanne Kohl; Nicole Weisschuh; Ditta Zobor; for the RD-CURE Consortium

Tags: genotype, genotype-phenotype associations, pde6a gene, phenotype, retinitis pigmentosa

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 9. doi:https://doi.org/10.1167/iovs.63.5.9

Autosomal Dominant Retinitis Pigmentosa–Associated TOPORS Protein Truncating Variants Are Exclusively Located in the Region of Amino Acid Residues 807 to 867 Open Access

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Junwen Wang; Yingwei Wang; Yi Jiang; Xueqing Li; Xueshan Xiao; Shiqiang Li; Xiaoyun Jia; Wenmin Sun; Panfeng Wang; Qingjiong Zhang

Tags: amino acids, proteins, retinitis pigmentosa, datasets, cohort studies

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 19. doi:https://doi.org/10.1167/iovs.63.5.19

Identification of a Complex Allele in IMPG2 as a Cause of Adult-Onset Vitelliform Macular Dystrophy Open Access

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Irene Vázquez-Domínguez; Catherina H. Z. Li; Zeinab Fadaie; Lonneke Haer-Wigman; Frans P. M. Cremers; Alejandro Garanto; Carel B. Hoyng; Susanne Roosing

Tags: adult, alleles, persistent postconcussive syndrome, postpolypectomy coagulation syndrome, vitelliform dystrophy

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 27. doi:https://doi.org/10.1167/iovs.63.5.27

Different Phenotypes Represent Advancing Stages of ABCA4-Associated Retinopathy: A Longitudinal Study of 212 Chinese Families From a Tertiary Center Open Access

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Yingwei Wang; Wenmin Sun; Jing Zhou; Xueqing Li; Yi Jiang; Shiqiang Li; Xiaoyun Jia; Xueshan Xiao; Jiamin Ouyang; Yueye Wang; Lin Zhou; Yuxi Long; Mengchu Liu; Yongyu Li; Zhen Yi; Panfeng Wang; Qingjiong Zhang

Tags: abca4 gene, chinese (other dialects), chinese people, longitudinal studies, phenotype

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 28. doi:https://doi.org/10.1167/iovs.63.5.28

Type 2 Diabetes, Fasting Glucose, Hemoglobin A1c Levels and Risk of Primary Open-Angle Glaucoma: A Mendelian Randomization Study Open Access

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Zhao Hu; Feixiang Zhou; Atipatsa Chiwanda Kaminga; Huilan Xu

Tags: diabetes mellitus, type 2, fasting blood glucose measurement, hemoglobin a, glycosylated, open-angle glaucoma, mendelian randomization analysis

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 37. doi:https://doi.org/10.1167/iovs.63.5.37

Glaucoma

Sodium Hyaluronate-Induced Ocular Hypertension in Rats Damages the Direction-Selective Circuit and Inner/Outer Retinal Plexiform Layers Open Access

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Agustina Noailles; Oksana Kutsyr; Aloma Mayordomo-Febrer; Pedro Lax; María López-Murcia; Silvia M. Sanz-González; María Dolores Pinazo-Durán; Nicolás Cuenca

Tags: ocular hypertension, sodium, rats, eye, intraocular pressure

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 2. doi:https://doi.org/10.1167/iovs.63.5.2

Microstructural Deformations Within the Depth of the Lamina Cribrosa in Response to Acute In Vivo Intraocular Pressure Modulation Open Access

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Yoav Glidai; Katie A. Lucy; Joel S. Schuman; Palaiologos Alexopoulos; Bo Wang; Mengfei Wu; Mengling Liu; Jonathan P. Vande Geest; Hirut G. Kollech; TingFang Lee; Hiroshi Ishikawa; Gadi Wollstein

Tags: cribriform plate, eye, intraocular pressure

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 25. doi:https://doi.org/10.1167/iovs.63.5.25

Ocular and Hemodynamic Factors Contributing to the Central Visual Function in Glaucoma Patients With Myopia Open Access

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Kyung Euy Hong; Seong Ah Kim; Da-Young Shin; Chan Kee Park; Hae-Young Lopilly Park

Tags: glaucoma, hemodynamics, myopia, vascular flow, vision

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 26. doi:https://doi.org/10.1167/iovs.63.5.26

Immunology and Microbiology

Host Immune Response and Associated Clinical Features in a Primary Cytomegalovirus Eye Infection Model Using Anterior Chamber Inoculation Open Access

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Chien-Chia Su; Chia-Mao Gao; Fu-Ti Peng; Tzuu-Shuh Jou; I-Jong Wang

Tags: anterior chamber of eye, cytokine, cytomegalovirus, cytomegalovirus infections, eye infections

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 18. doi:https://doi.org/10.1167/iovs.63.5.18

Lens

Oxysterol Compounds in Mouse Mutant αA- and αB-Crystallin Lenses Can Improve the Optical Properties of the Lens Open Access

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Kehao Wang; Masato Hoshino; Kentaro Uesugi; Naoto Yagi; Barbara K. Pierscionek; Usha P. Andley

Tags: crystallins, lens (device), lens, crystalline, mice, optics

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 15. doi:https://doi.org/10.1167/iovs.63.5.15

Retina

Photoreceptor Manifestations of Primary Mitochondrial Optic Nerve Disorders Open Access

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Yin-Hsi Chang; Eugene Yu-Chuan Kang; Pei-Kang Liu; Sarah R. Levi; Hung-Hsuan Wang; Yun-Ju Tseng; Go Hun Seo; Hane Lee; Lung-Kun Yeh; Kuan-Jen Chen; Wei-Chi Wu; Chi-Chun Lai; Laura Liu; Nan-Kai Wang

Tags: mitochondria, optic atrophy, autosomal dominant, optic atrophy, hereditary, leber, optic nerve disorders, pathophysiology

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 5. doi:https://doi.org/10.1167/iovs.63.5.5

Alpha-Smooth Muscle Actin Expression and Parafoveal Blood Flow Pathways Are Altered in Preclinical Diabetic Retinopathy Open Access

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Dong An; Jonathan Chung-Wah-Cheong; Dao-Yi Yu; Chandrakumar Balaratnasingam

Tags: actins, blood capillaries, diabetic retinopathy, muscle, parafoveal region

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 8. doi:https://doi.org/10.1167/iovs.63.5.8

Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse Open Access

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Wanjing Huang; Qiang Xu; Feng Liu; Jing Su; Dongchang Xiao; Lei Tang; Zhao-Zhe Hao; Ruifeng Liu; Kangjian Xiang; Yalan Bi; Zhichao Miao; Xialin Liu; Yizhi Liu; Sheng Liu

Tags: abdominal compartment syndrome, acute coronary syndromes, american cancer society, american college of surgeons, mice

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 13. doi:https://doi.org/10.1167/iovs.63.5.13

Ablation of Ctrp9, Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina Open Access

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Daiki Inooka; Yoshihiro Omori; Noriyuki Ouchi; Koji Ohashi; Yuto Kawakami; Yoshito Koyanagi; Chieko Koike; Hiroko Terasaki; Koji M. Nishiguchi; Shinji Ueno

Tags: ligands, mice, retina, retinal cone, ablation

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 14. doi:https://doi.org/10.1167/iovs.63.5.14

Single-Cell Protein and Transcriptional Characterization of Epiretinal Membranes From Patients With Proliferative Vitreoretinopathy Open Access

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Yannik Laich; Julian Wolf; Rozina Ida Hajdu; Anja Schlecht; Felicitas Bucher; Laurenz Pauleikhoff; Martin Busch; Gottfried Martin; Henrik Faatz; Saskia Killmer; Bertram Bengsch; Andreas Stahl; Albrecht Lommatzsch; Günther Schlunck; Hansjürgen Agostini; Stefaniya Boneva; Clemens Lange

Tags: epiretinal membrane, proteins, tissue membrane, transcription, genetic, vitreoretinopathy, proliferative

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 17. doi:https://doi.org/10.1167/iovs.63.5.17

Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway Open Access

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Pan Gao; Danna Jia; Pei Li; Yuwen Huang; Hualei Hu; Kui Sun; Yuexia Lv; Xiang Chen; Yunqiao Han; Zuxiao Zhang; Xiang Ren; Qing Wang; Fei Liu; Zhaohui Tang; Mugen Liu

Tags: lipid droplet, ppar alpha, zebrafish, crystal structure, retinal pigment cell

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 32. doi:https://doi.org/10.1167/iovs.63.5.32

Abnormal Retinal Vessel Architecture in Albinism and Idiopathic Infantile Nystagmus Open Access

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Shafak Toufeeq; Irene Gottlob; Zhanhan Tu; Frank A. Proudlock; Anastasia Pilat

Tags: albinism, pathologic nystagmus, retinal vessels

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 33. doi:https://doi.org/10.1167/iovs.63.5.33

High-Density Optical Coherence Tomography Analysis Provides Insights Into Early/Intermediate Age-Related Macular Degeneration Retinal Layer Changes Open Access

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Matt Trinh; Michael Kalloniatis; David Alonso-Caneiro; Lisa Nivison-Smith

Tags: age-related macular degeneration, eye, optical coherence tomography, retina, correlation studies

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 36. doi:https://doi.org/10.1167/iovs.63.5.36

Visual Neuroscience

The Association Between Acquired Color Deficiency and PET Imaging of Neurodegeneration in Mild Cognitive Impairment and Alzheimer Disease Open Access

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Kallene Summer Moreira Vidal; Diego Decleva; Mirella Telles Salgueiro Barboni; Balàzs Vince Nagy; Paulo Augusto Hidalgo de Menezes; Avinash Aher; Artur Martins Coutinho; Paula Squarzoni; Daniele de Paula Faria; Fabio Luis de Souza Duran; Carlos Alberto Buchpiguel; Jan Kremers; Geraldo Busatto Filho; Dora Fix Ventura

Tags: alzheimer's disease, brain, color, color vision, electroretinography

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 20. doi:https://doi.org/10.1167/iovs.63.5.20

Cortical Atrophy Predicts Visual Performance in Long-Term Central Retinal Disease; GCL, pRNFL and Cortical Thickness Are Key Biomarkers Open Access

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Rachel L. W. Hanson; Heidi A. Baseler; Archana Airody; Antony B. Morland; Richard P. Gale

Tags: biological markers, cerebral atrophy, eye, retinal diseases, visual pathways

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 35. doi:https://doi.org/10.1167/iovs.63.5.35

Visual Psychophysics and Physiological Optics

Psychophysical Reverse Correlation Revealed Broader Orientation Tuning and Prolonged Reaction Time in Amblyopia Open Access

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Jinli Zhu; Xiaowei Ruan; Cheng Li; Junli Yuan; Yan Yang; Wenhua Zhang; Hanyi Zhang; Zuopao Zhuo; Fang-Fang Yan; Chang-Bing Huang; Fang Hou

Tags: amblyopia, psychophysics, reaction time

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 3. doi:https://doi.org/10.1167/iovs.63.5.3

Electroencephalography Study of Frontal Lobe Evoked by Dynamic Random-Dot Stereogram Open Access

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Yueping Li; Lili Shen; Mingyang Sun

Tags: electroencephalography, frontal lobe, perception, wave - physical agent

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 7. doi:https://doi.org/10.1167/iovs.63.5.7

Perceptual Adaptation to Continuous Versus Intermittent Exposure to Spatial Distortions Open Access

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Iona R. McLean; Tyler S. Manning; Emily A. Cooper

Tags: cues, eyeglasses, health disparity, shape, vision disparity

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 29. doi:https://doi.org/10.1167/iovs.63.5.29

Letters to the Editor

Re: Trivizki et al. Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization Open Access

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Maximilian Pfau; Steffen Schmitz-Valckenberg; Frank G. Holz; Monika Fleckenstein

Tags: atrophy, growth rate, macular neovascularization

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 10. doi:https://doi.org/10.1167/iovs.63.5.10

Author Response: Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization Open Access

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Omer Trivizki; Eric Michael Moult; Liang Wang; Prashanth Iyer; Yingying Shi; Giovanni Gregori; William Feuer; James G. Fujimoto; Philip J. Rosenfeld

Tags: atrophy, growth rate, macular neovascularization

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 11. doi:https://doi.org/10.1167/iovs.63.5.11

Smokers’ Choroidal Changes Open Access

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Alessio Marino; Ciro Sannino; Nicola Rosa

Tags: smokers

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 21. doi:https://doi.org/10.1167/iovs.63.5.21

Author Response: Smokers’ Choroidal Changes Open Access

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Xin Wei; Rupesh Agrawal

Tags: smokers

Investigative Ophthalmology & Visual Science May 2022, Vol.63, 22. doi:https://doi.org/10.1167/iovs.63.5.22

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