Volume 63 Issue 6 | IOVS

Ciliary Muscle Dimension Changes With Accommodation Vary in Myopia and Emmetropia Open Access

Dinesh Kaphle; Katrina L. Schmid; Leon N. Davies; Marwan Suheimat; David A. Atchison

Tags: ciliary muscle, emmetropia, eye, myopia, visual accommodation

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 24. doi:https://doi.org/10.1167/iovs.63.6.24

Retinal Pigment Epithelium in Human Donor Eyes Contains Higher Levels of Bisretinoids Including A2E in Periphery than Macula Open Access

PDF

Ankita Kotnala; Srinivasan Senthilkumari; Gong Wu; Thomas G. Stewart; Christine A. Curcio; Nabanita Halder; Sundararajan Baskar Singh; Atul Kumar; Thirumurthy Velpandian

Tags: donors, eye, macula lutea, retina, retinal pigment epithelium

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 6. doi:https://doi.org/10.1167/iovs.63.6.6

Potential Therapeutic Role of Bone Morphogenic Protein 7 (BMP7) in the Pathogenesis of Graves’ Orbitopathy Open Access

PDF

Bo Yi Kim; Soo Hyun Choi; Ji-Young Kim; JaeSang Ko; Jong In Yook; Hyun Sil Kim; Eun Jig Lee; Don O. Kikkawa; Jin Sook Yoon

Tags: body tissue, bone morphogenetic proteins, fibroblasts, molecule, pathogenesis

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 7. doi:https://doi.org/10.1167/iovs.63.6.7

Early Dry Eye Disease Onset in a NOD.H-2^h4 Mouse Model of Sjögren's Syndrome Open Access

PDF

Lili Li; Kimberly J. Jasmer; Jean M. Camden; Lucas T. Woods; Adam L. Martin; Yong Yang; Maria Layton; Michael J. Petris; Olga J. Baker; Gary A. Weisman; Carisa K. Petris

Tags: mice, dry eye syndromes, sjogren's syndrome

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 18. doi:https://doi.org/10.1167/iovs.63.6.18

Clinical and Epidemiologic Research

Sports and Myopia: An Investigation on the Prevalence and Risk Factors of Myopia in Young Sports-Related Groups in Tianjin, China Open Access

PDF

Mingxue Zhang; Zhiyong Sun; Xinlei Zhu; Haokun Zhang; Yun Zhu; Hua Yan

Tags: myopia, prevalence, risk factors, sports, china

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 27. doi:https://doi.org/10.1167/iovs.63.6.27

Cornea

Corneal Epithelium–Derived Netrin-1 Alleviates Dry Eye Disease via Regulating Dendritic Cell Activation Open Access

PDF

Chaoqun Yu; Peng Chen; Jing Xu; Susu Wei; Qilong Cao; Chuanlong Guo; Xianggen Wu; Guohu Di

Tags: cornea, corneal epithelium, dendritic cells, dry eye syndromes, mice

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.6.1

Lysozyme Protects Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Inflammation in Human Corneal Epithelial Cells Open Access

PDF

Yinting Song; Haokun Zhang; Yanfang Zhu; Xiao Zhao; Yi Lei; Wei Zhou; Jinguo Yu; Xue Dong; Xiaohong Wang; Mei Du; Hua Yan

Tags: covid-19, infections, inflammation, muramidase, proteins

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 16. doi:https://doi.org/10.1167/iovs.63.6.16

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

The Orientation Selectivity of Dichoptic Masking Suppression is Contrast Dependent in Amblyopia Open Access

PDF

Ling Gong; Lili Wei; Xi Yu; Alexandre Reynaud; Robert F. Hess; Jiawei Zhou

Tags: amblyopia, eye, masks, perceptual masking

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 9. doi:https://doi.org/10.1167/iovs.63.6.9

Inhibition of Heat Shock Protein B8 Alleviates Retinal Dysfunction and Ganglion Cells Loss Via Autophagy Suppression in Mouse Axonal Damage Open Access

PDF

Feijia Xie; Zongyuan Li; Ning Yang; Jiayi Yang; Dihao Hua; Jinyuan Luo; Tao He; Yiqiao Xing

Tags: autophagy, heat-shock proteins, mice, optic nerve, pathophysiology

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 28. doi:https://doi.org/10.1167/iovs.63.6.28

Genetics

Phenotype-Based Genetic Analysis Reveals Missing Heritability of ABCA4-Related Retinopathy: Deep Intronic Variants and Copy Number Variations Open Access

PDF

Lu Tian; Chunjie Chen; Yuning Song; Xiaohui Zhang; Ke Xu; Yue Xie; Zi-Bing Jin; Yang Li

Tags: abca4 gene, alleles, copy number polymorphism, genetic analysis, introns

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 5. doi:https://doi.org/10.1167/iovs.63.6.5

Sonic Hedgehog Intron Variant Associated With an Unusual Pediatric Cortical Cataract Open Access

PDF

Terri L. Young; Kristina N. Whisenhunt; Sarah M. LaMartina; Alex W. Hewitt; David A. Mackey; Stuart W. Tompson

Tags: cataract, childhood, cortical cataract, introns, pediatrics, shh gene

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 25. doi:https://doi.org/10.1167/iovs.63.6.25

Glaucoma

Distribution of Pigment Particles in Aqueous Drainage Structures in a DBA/2J Mouse Model of Pigmentary Glaucoma Open Access

PDF

Liping Pu; Rongyao Zhou; Qian Li; Guoping Qing

Tags: intraocular pressure, mice, pigment, drainage procedure, discharge, body substance

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2. doi:https://doi.org/10.1167/iovs.63.6.2

Potential Mechanisms of Intraocular Pressure Reduction by Micropulse Transscleral Cyclophotocoagulation in Rabbit Eyes Open Access

PDF

Hotaka Nemoto; Megumi Honjo; Michiaki Okamoto; Koichiro Sugimoto; Makoto Aihara

Tags: cardiac progenitor cells, ciliary body, eye, intraocular pressure, lasers

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3. doi:https://doi.org/10.1167/iovs.63.6.3

Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells Open Access

PDF

William W. MacDonald; Swarup S. Swaminathan; Jae Young Heo; Alexandra Castillejos; Jessica Hsueh; Brian J. Liu; Diane Jo; Annie Du; Hyunpil Lee; Min Hyung Kang; Douglas J. Rhee

Tags: intraocular pressure, mice, proteins, sparc study, body tissue

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 8. doi:https://doi.org/10.1167/iovs.63.6.8

High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study Open Access

PDF

Denis Plotnikov; Yu Huang; Anthony P. Khawaja; Paul J. Foster; Zhuoting Zhu; Jeremy A. Guggenheim; Mingguang He

Tags: blood pressure, glaucoma, hypertension, intraocular pressure, mendelian randomization analysis

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 29. doi:https://doi.org/10.1167/iovs.63.6.29

Immunology and Microbiology

PPAR-α Agonist Fenofibrate Ameliorates Sjögren Syndrome–Like Dacryoadenitis by Modulating Th1/Th17 and Treg Cell Responses in NOD Mice Open Access

PDF

Xingyi Guo; Weiyu Dang; Na Li; Ying Wang; Deming Sun; Hong Nian; Ruihua Wei

Tags: dacryoadenitis, dry eye syndromes, fenofibrate, peroxisome proliferator-activated receptors, regulatory t-lymphocytes

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 12. doi:https://doi.org/10.1167/iovs.63.6.12

Lens

TFEB-Mediated Lysosomal Restoration Alleviates High Glucose-Induced Cataracts Via Attenuating Oxidative Stress Open Access

PDF

Yan Sun; Xiaoran Wang; Baoxin Chen; Mi Huang; Pengjuan Ma; Lang Xiong; Jingqi Huang; Jieping Chen; Shan Huang; Yizhi Liu

Tags: autophagy, cataract, diabetes mellitus, glucose, lens (device)

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 26. doi:https://doi.org/10.1167/iovs.63.6.26

Physiology and Pharmacology

Sleep Loss Causes Dysfunction in Murine Extraorbital Lacrimal Glands Open Access

PDF

Shenzhen Huang; Hongli Si; Jiangman Liu; Di Qi; Xiaoting Pei; Dingli Lu; Sen Zou; Zhijie Li

Tags: genes, mice, pathophysiology, rhythm, sleep deprivation

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 19. doi:https://doi.org/10.1167/iovs.63.6.19

Retina

The Ganglion Cell-Inner Plexiform Layer Thickness/Vessel Density of Superficial Vascular Plexus Ratio According to the Progression of Diabetic Retinopathy Open Access

PDF

Jae-Yun Sung; Min-Woo Lee; Hyung-Bin Lim; Cheon-Kuk Ryu; Hwa-Young Yu; Jung-Yeul Kim

Tags: diabetic retinopathy, ganglia, superficial vascular plexus, retinal vasculature

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4. doi:https://doi.org/10.1167/iovs.63.6.4

A Novel Hypoxia-inducible Factor 1α Inhibitor KC7F2 Attenuates Oxygen-induced Retinal Neovascularization Open Access

PDF

Xiaoyu Tang; Kaixuan Cui; Xi Lu; Peiqi Wu; Shanshan Yu; Boyu Yang; Yue Xu; Xiaoling Liang

Tags: hypoxia, mice, oxygen, retina, retinal neovascularization

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 13. doi:https://doi.org/10.1167/iovs.63.6.13

Exploring Reticular Pseudodrusen Extent and Impact on Mesopic Visual Sensitivity in Intermediate Age-Related Macular Degeneration Open Access

PDF

Himeesh Kumar; Robyn H. Guymer; Lauren A. B. Hodgson; Xavier Hadoux; Zhichao Wu

Tags: age-related macular degeneration, drusen, eye, reticular pseudodrusen, diagnostic imaging

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 14. doi:https://doi.org/10.1167/iovs.63.6.14

Axial Length Distributions in Patients With Genetically Confirmed Inherited Retinal Diseases Open Access

PDF

Katie M. Williams; Michalis Georgiou; Angelos Kalitzeos; Isabelle Chow; Pirro G. Hysi; Anthony G. Robson; Gareth Lingham; Fred K. Chen; David A. Mackey; Andrew R. Webster; Christopher J. Hammond; Polina Prokhoda; Joseph Carroll; Michel Michaelides; Omar A. Mahroo

Tags: advanced life support, amyotrophic lateral sclerosis, antilymphocyte globulin, cohort studies, oculocutaneous albinism type 2

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 15. doi:https://doi.org/10.1167/iovs.63.6.15

The Association of Fluid Volatility With Subretinal Hyperreflective Material and Ellipsoid Zone Integrity in Neovascular AMD Open Access

PDF

Justis P. Ehlers; Nikhil Patel; Peter K. Kaiser; Jeffrey S. Heier; David M. Brown; Xiangyi Meng; Jamie Reese; Leina Lunasco; Thuy K. Le; Ming Hu; Sunil K. Srivastava

Tags: exudative age-related macular degeneration, eye, personal integrity, volume, attenuation

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 17. doi:https://doi.org/10.1167/iovs.63.6.17

Characteristics of the Optic Nerve Head in Myopic Eyes Using Swept-Source Optical Coherence Tomography Open Access

PDF

Dan Cheng; Kaiming Ruan; Minhui Wu; Yilin Qiao; Weiqian Gao; Hengli Lian; Meixiao Shen; Fangjun Bao; Yizeng Yang; Jun Zhu; Haiying Huang; Xianwei Meng; Lijun Shen; Yufeng Ye

Tags: eye, myopia, optic disk, optical coherence tomography, microvascular network

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 20. doi:https://doi.org/10.1167/iovs.63.6.20

Irisin Attenuates Pathological Neovascularization in Oxygen-Induced Retinopathy Mice Open Access

PDF

Jieqiong Zhang; Zhifei Liu; Haoqian Wu; Xi Chen; Qiumei Hu; Xue Li; Linlin Luo; Shiyang Ye; Jian Ye

Tags: irisin, mice, neovascularization, pathologic, retinal diseases, oxygen

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 21. doi:https://doi.org/10.1167/iovs.63.6.21

Scotopic Contour Deformation Detection Reveals Early Rod Dysfunction in Age-Related Macular Degeneration With and Without Reticular Pseudodrusen Open Access

PDF

Brett G. Jeffrey; Oliver J. Flynn; Laryssa A. Huryn; Maximilian Pfau; Catherine A. Cukras

Tags: age-related macular degeneration, dark adaptation, eye, pathophysiology, reticular pseudodrusen

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 23. doi:https://doi.org/10.1167/iovs.63.6.23

Retinal Oxygen Delivery and Metabolism Response to Hyperoxia During Bilateral Common Carotid Artery Occlusion in Rats Open Access

PDF

Sophie Leahy; Nathanael Matei; Norman P. Blair; Mahnaz Shahidi

Tags: common carotid artery, hyperoxia, metabolism, oxygen delivery, rats

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 30. doi:https://doi.org/10.1167/iovs.63.6.30

Retinal Cell Biology

Characterization of Double-Strand Break Repair Protein Ku80 Location Within the Murine Retina Open Access

PDF

Brigitte Müller; Franziska Serafin; Leonie Luise Laucke; Wilhelm Rheinhard; Tobias Wimmer; Knut Stieger

Tags: mice, proteins, retina, photoreceptors, double strand break repair

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 22. doi:https://doi.org/10.1167/iovs.63.6.22

Letters to the Editor

Author Response: Relationship of Choroidal Vasculature and Choriocapillaris Flow With Alterations of Salivary α-Amylase Patterns in Central Serous Chorioretinopathy Open Access

PDF

Fabio Scarinci; Francesca Romana Patacchioli; Eliana Costanzo; Mariacristina Parravano

Tags: amylases, central serous chorioretinopathy, fluid flow, vasculature

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 10. doi:https://doi.org/10.1167/iovs.63.6.10

Letter to the Editor: Relationship of Choroidal Vasculature and Choriocapillaris Flow With Alterations of Salivary α-Amylase Patterns in Central Serous Chorioretinopathy Open Access

PDF

Matteo Menean; Riccardo Sacconi; Giuseppe Querques

Tags: amylases, central serous chorioretinopathy, fluid flow, vasculature

Investigative Ophthalmology & Visual Science June 2022, Vol.63, 11. doi:https://doi.org/10.1167/iovs.63.6.11

This feature is available to authenticated users only.

To View More...

You must be signed into an individual account to use this feature.