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ARVO Annual Meeting Abstract

Next-Generation Sequencing Panel Results for Inherited Retinal Dystrophy in a Large Pediatric Cohort Open Access
Iker Sánchez Navarro; Kimberly Gall; Julie Hathaway; Alicia Scocchia; Kati Kämpjärvi; Johanna Känsäkoski; Pernilla von Nandelstadh; Marta Gandia; Sanna Vattulainen-Collanus; Ka-Yan Mak; Mari-Liis Mikk; Laura Sarantaus; Hanna Västinsalo; Inka Saarinen; Sari Tuupanen; Juha Koskenvuo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1. doi:
Randomized Trial of Treat-and-Extend Intravitreal Aflibercept for Radiation Retinopathy: 1-Year Outcomes Open Access
Stephanie Trejo Corona; Cecilia Villanueva Boone; Chelsey Moore; Alex Brown; Jose Munoz; Thomas Aaberg Jr.; Amy C Schefler
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 0001. doi:
A refined amplification-free long-read sequencing method to interrogate TCF4 triplet repeats associated with Fuchs endothelial corneal dystrophy Open Access
Christina Zarouchlioti; Nathaniel Jordan Hafford-Tear; Yu-Chih Tsai; Anita Szabo; Nihar Bhattacharyya; Amanda Sadan; Alison J Hardcastle; Petra Liskova; Nikolas Pontikos; Stephen Tuft; Alice E Davidson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2. doi:
The retinal toxicity of the pro-inflammatory and amyloidogenic S100A9 proteins Open Access
Shiri Zayit-Soudry; Michal Harel; Amanda Qarawani; Rony Ben Zvi Elimelech; Chen Itzkovich; Rami Khoury; Shadi Safuri; Efrat Naaman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 0002. doi:
Deciphering non-coding genetic variants via integrative single cell multi-omics analysis Open Access
Rui Chen; Jun Wang; Xuesen Cheng; Qingnan Liang; Jun Wang; Margaret M DeAngelis; Yumei Li
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3. doi:
Integrating genetics and metabolomics data reveals putative mechanisms for age-related macular degeneration Open Access
Xikun Han; Ines Lains; Jun Li; Qibin Qi; Bing Yu; Jessica Lasky-Su; Joan W Miller; Frank Hu; Walter Willett; Stuart MacGregor; Deeba Husain; Liming Liang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 0003. doi:
Single Nucleus Multi-modal Analysis of the Aging Mouse Retina Open Access
Anne Marie Berry; Kelsey Dang; Pooja Biswas; Shikha Pachauri; Ryan Lancione; Manisha Dagar; Donita Garland; Sebastian Preissl; Allen Wang; Radha Ayyagari
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4. doi:
Patterns of gene expression vary among macular tissues and clinical stages of Age-related Macular Degeneration Open Access
Charles Zhang; Leah A Owen; John Lillvis; Brian Madow; Akbar Shakoor; Albert T Vitale; Tamim Shaikh; Neena B Haider; Michael Farkas; Lindsay Farrer; Ivana K Kim; Margaret M DeAngelis
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 0004. doi:
Revisiting WGS data reveals previously overlooked structural variants disrupting IRD-associated genes Open Access
Suzanne de Bruijn; Kornelia Neveling; Rebekkah J Hitti-Malin; Jordi Corominas; Janine Reurink; Hannie Kremer; Ronald J.E. Pennings; Marcel Nelen; Christian Gilissen; Frans P Cremers; Alexander Hoischen; Susanne Roosing
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 5. doi:
APE1/Ref-1 is highly expressed in murine laser-induced choroidal neovascularization and human neovascular age-related macular degeneration Open Access
Anbukkarasi Muniyandi; Gabriella D Hartman; Kristina Day; Xiaoping Qi; Michael Boulton; Mark R Kelley; Timothy William Corson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 0005. doi:
Retinal Horizontal Cell TDP-43 Pathology in Chronic Traumatic Encephalopathy Patients’ Retinas Open Access
Jihee Choi; Chiara De Lillo; Vanessa S. Goodwill; David G. Coughlin; Christina J. Sigurdson; Victor E. Alvarez; Annie Hiniker; Ann C. Mckee; Jonathan Lin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 0006. doi:
Identification of Retinal Cell Types Based on Single-Cell Transcriptomics Open Access
Yeganeh Madadi; Jian Sun; hao Chen; Robert W. Williams; Siamak Yousefi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 6. doi:
Single-nucleus multi-modal analysis of MFRP associated retinal degeneration Open Access
Shikha Pachauri; Kelsey Dang; Pooja Biswas; Anil Kumar Chekuri; Manisha Dagar; Anne Marie Berry; Berzhan Kurmanov; Ryan Lancione; Donita Garland; Sebastian Preissl; Allen Wang; Radha Ayyagari
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 7. doi:
Prion Deposits Preferentially Accumulate in the Retinal Outer Plexiform Layer in Patients with Sporadic Creutzfeldt-Jakob Disease (sCJD) Open Access
Chiara De Lillo; Jihee Choi; Vanessa S. Goodwill; Ian Dryden; Ana Arcia Franchini; Christina J. Sigurdson; Jonathan Lin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 0007. doi:
Chronic intraocular pressure elevation alters cerebrovascular reactivity in the visual cortex and basal forebrain Open Access
Russell Chan; Yixi Xue; Ji Won Bang; Muneeb A Faiq; Thajunnisa Sajitha; Royce Lee; Peiying Liu; Christopher Leung; Gadi Wollstein; Joel S Schuman; Kevin C. Chan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 8. doi:
Glaucoma-associated human Optineurin mutations increase transmitophagy in the Xenopus laevis tadpole optic nerve Open Access
Yaeram Jeong; Nicholas Marsh-Armstrong
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 9. doi:
Retinal ex vivo live imaging indicates microglia interaction with synaptic sites in experimental glaucoma Open Access
Tonatiuh Garcia Ruiz; Alfred K Yu; Jeanette Hyer; Luca Della Santina; Yvonne Ou
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 10. doi:
APOE4 impairs the response of neurodegenerative microglia and prevents neuronal loss in glaucoma Open Access
Milica Margeta; Kristen M Pitts; Oleg Butovsky
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 11. doi:
Restoration of mitochondrial axonal transport by adaptor supplementation prevents neurodegeneration and rescues visual function in glaucoma Open Access
Heberto Quintero; Yukihiro Shiga; Nicolas A Belforte; Luis Alarcon-Martinez; Sana El Hajji; Deborah Villafranca-Baughman; Florence Dotigny; Adriana Di Polo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 12. doi:
Early neuroinflammatory responses in the visual pathway in a feline inherited glaucoma model Open Access
Kazuya Oikawa; Julie Kiland; Virginia Mathu; Odalys Torne; Gillian J McLellan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 13. doi:
Induced ablation of scleral TGF-β signaling in mutant mice increases susceptibility to IOP-induced optic nerve damage Open Access
Magdalena Schneider; Andrea E. Dillinger; Ernst R. Tamm
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 14. doi:
Function and therapeutic potential of glutaredoxin (Grx) system in the lens Open Access
Hongli Wu; Kayla Green; Yang Liu; Jinmin Zhang; Yu Yu; Kevin Lal; My-Lien Au
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 15. doi:
Mapping the universe of Eph and ephrin transcripts in adult mouse lenses Open Access
Subashree Murugan; Catherine Cheng
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 16. doi:
α-Crystallin chaperone mimetic small molecules as a paradigm for cataract prevention by inhibition of lens γ-crystallin aggregation Open Access
Vincent M Monnier; Sidra Islam; Michael Do; Brett Frank; Samuel G Wheeler; Xingjun Fan; Kirsten J Lampi; David R Sell
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 17. doi:
Topical instillation of Metformin Prevents Oxidative Stress-Induced Eye Lens Opacity Through Induction of AMPK-Nrf2-Mediated Antioxidant Pathway Open Access
Dhirendra P Singh; Bhavana Chhunchha; Ronald R krueger; Eri Kubo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 18. doi:
Functional interaction between connexin 46 and periaxin in cataractogenesis Open Access
Xiaohua Gong; Vasantha Rao; Chun-hong Xia
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 19. doi:
Dysregulation of Autophagy Occurs During Congenital Cataract Development in CRYβA1/A3-ΔG91 Mice. Open Access
Akosua Konadu Boateng; Roy Joseph; Om P Srivastava
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 20. doi:
A PCO Predictive In Vitro Model to Examine the Role of Fibronectin and IOL Surface Property on PCO formation Open Access
Liping Tang; Joyita Roy; Arjun Jaitli; Amjad Chatila
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 21. doi:
PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids Open Access
Nobuhiko Shiraki; Kazuichi Maruyama; Ryuhei Hayashi; Susumu Sakimoto; Kohji Nishida
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 22. doi:
Augmentation of Protective Microglia Restricts Outer Retinal Degeneration and Preserves Vision Open Access
Chen Yu; Eleonora M Lad; Alan Proia; Daniel R Saban
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 23. doi:
Senescent Macrophage Lead to Age Related Macular Degeneration-Like Phenotype in an in vitro 3D RPE/Choroid Model Open Access
Russell Quinn; Eric Nguyen; Tea Soon Park; Congxiao Zhang; Amir Ali; Rishabh Hirday; Devika Bose; Robert N Fariss; Marc Ferrer; Kapil Bharti
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 24. doi:
CCR2+ monocytes critically contribute to subretinal fibrosis at the chronic stage of the disease. Open Access
Manon SZCZEPAN; Maria Llorian-Salvador; Matthias Mack; Mei Chen; Heping Xu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 25. doi:
Single cell RNA sequencing reveals a subtype of pro-angiogenic classical monocyte-derived macrophages during experimental choroidal neovascularization Open Access
Jeremy Lavine; Steven Droho; Carla M Cuda; Harris Perlman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 26. doi:
MMP9 associated with choroidal neovascularization in AMD is expressed in human immune cells Open Access
Elliott H Sohn; Chunhua Jiao; Andrew P Voigt; Todd E Scheetz; Robert F Mullins
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 27. doi:
CCL26 expression is elevated in the retinal pigment epithelium in atrophic AMD Open Access
Rashmi Dubey; Sushil Kumar Dubey; kyung sik jung; Kabhilan Mohan; Mark Ellsworth Kleinman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 28. doi:
Race, Ethnicity, and Sex Differences in Retinal Detachment Repairs: A US Claims-Based Analysis Open Access
Amee D Azad; Ahmad Al Moujahed; Daniel Vail; Darius M Moshfeghi; Natalia Callaway
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 29. doi:
Imaging Predictors of Functional Outcomes Following Rhegmatogenous Retinal Detachment Repair Open Access
Wei Wei Lee; Rajeev Hemant Muni
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 30. doi:
Acute traction retinal detachment (stage 4) in retinopathy of prematurity: outcomes of endoscopic vitrectomy in 99 consecutive cases. Open Access
Sui Chien Wong; James Wawrzynski; Damien Yeo; Robert H Henderson; Chetan K Patel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 31. doi:
A Retrospective Audit of Large Macular Hole Repair Techniques: ILM Peel vs ILM Flap. Open Access
Megan Caitlin Quinn; David Yorston
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 32. doi:
Predicting visual improvement after macular hole surgery: a combined model using deep learning and clinical features Open Access
Alexandre Lachance; Mathieu Godbout; Fares Antaki; Mélanie Hébert; Serge Bourgault; Mathieu Caissie; Éric Tourville; Audrey Durand; Ali Dirani
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 33. doi:
Surgical outcomes of scleral buckling for rhegmatogenous retinal detachment using the NGENUITY three-dimensional visualization system with a guarded light pipe Open Access
John Miller; Jared Sokol; Cassie Ann Ludwig; Grace Baldwin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 34. doi:
Three Dimensional Digitally-Enabled Intraoperative OCT Compared with Conventional Microscope-Integrated Intraoperative OCT in Vitreoretinal Surgery: A Post Hoc Analysis of the DISCOVER St... Open Access
Katherine Talcott; Austen Knapp; Sunil K Srivastava; Aleksandra V Rachitskaya; Sumit Sharma; Rishi P Singh; Alex Yuan; Jamie Reese; Justis P Ehlers
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 35. doi:
Generation of a compound heterozygous ABCA4 phenotype in a Stargardt rat model for the G1961E mutation Open Access
Therese Cronin; Lyse Libeau; Joanna Demilly; Séverine Remy; Mikaël Croyal; Ignacio Anegon; Oumeya Adjali
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 36. doi:
Safety and efficacy of fovea-involving half-dose photodynamic therapy for chronic central serous chorioretinopathy Open Access
Helena Margaret Anthonia Feenstra; Roselie M.H. Diederen; Martine J.C.M. Lamme; Sascha Fauser; Susan M. Downes; Reinier O. Schlingemann; Carel C B Hoyng; Elon H.C. van Dijk; Camiel J F Boon
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 37. doi:
ALK-001 (C20-D3-Vitamin A) slows the growth of atrophic lesions in ABCA4-related Stargardt Disease: Results of a Phase 2 placebo-controlled clinical trial (TEASE study) Open Access
Hendrik P Scholl; Gabrielle DeBartolomeo; Ilyas Washington; Leonide Saad
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 38. doi:
Transcriptome analysis of the human choroid qualifies endothelial androgen responses as a disease driver for Central Serous Chorioretinopathy Open Access
Steffen Emil Künzel; Sandrine Helene Künzel; Dominik Pascal Frentzel; Dominika Pohlmann; Lynn Zur Bonsen; Oliver Zeitz; Antonia M. Joussen; Alexandre Dubrac
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 39. doi:
Zebrafish models of Stargardt Disease reveal RPE and cone photoreceptor defects that suggest mechanisms of disease Open Access
Abbie M Jensen; John Willoughby
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 40. doi:
Single-molecule Molecular Inversion Probes allow cost-effective targeted sequencing of all genes and loci associated with macular diseases. Open Access
Rebekkah J Hitti-Malin; Susanne Roosing; Claire-Marie Dhaenens; Anneke I Den Hollander; G.Jane Farrar; Daan Panneman; Erica G.M Boonen; Laura de Rooij; Mariana Guimaraes Ramos; Maartje van de Vorst; Bart de Koning; Christian Gilissen; Alexander Hoischen; Frans P Cremers
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 41. doi:
The Sensitivity and Specificity of FLIO (Fluorescence Lifetime Imaging Ophthalmoscopy) when Imaging Patients with MacTel Open Access
Lydia Sauer; Alexandra Vitale; Paul S Bernstein
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 42. doi:
Receptive field diversity in the primate foveal retina Open Access
Sara S Patterson; Tyler Godat; Qiang Yang; William Merigan; David R Williams
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 43. doi:
In vivo calcium imaging reveals L/M opponent ganglion cells consistent with single cone receptive field centers at the macaque foveal center Open Access
Tyler Godat; Nicolas P. Cottaris; Sara S Patterson; Kendall Kohout; Keith Parkins; Qiang Yang; Jennifer M. Strazzeri; Juliette E McGregor; David H Brainard; William Merigan; David R Williams
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 44. doi:
Synaptic inputs to macaque intrinsically-photosensitive ganglion cells Open Access
David W Marshak; Sara S Patterson; James Kuchenbecker; Joel Yearick; Emma Yang; Judith Ogilvie; Andrea Bordt; Jay Neitz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 45. doi:
Functional diversity of intrinsically photosensitive retinal ganglion cells in the mouse retina. Open Access
Benjamin Sivyer; Michael Berry
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 46. doi:
Asymmetries in the vertical optokinetic reflex result from disproportionate excitation to complementary ON direction-selective retinal ganglion cell types Open Access
Scott C Harris; Felice A Dunn
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 47. doi:
A Retinal Representation of Environmental Illumination within the Master Circadian Clock Open Access
Philippe Morquette; Michael Tri Hoang Do
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 48. doi:
The role of the vLGN in non-image-forming visual behaviors and its underlying circuit organization Open Access
Corinne Beier; Ze Zhang; Martina Thurman; Samer Hattar
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 49. doi:
Accommodative Behavior during Multifocal Soft Contact Lens Wear Can Predict Myopia Progression in Children Open Access
Xiaoying Zhu; Zachary Zlatin; Harrison Feng; David Troilo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 403. doi:
Dynamic OFF stimulation reduces perceived saturation of red color, similarly in myopes and emmetropes Open Access
Frank Schaeffel; Barbara Swiatczak
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 404. doi:
Changes in visual function in eyes with myopic traction maculopathy over 1 year Open Access
Qiu Ying Wong; Yee Shan Dan; Chloe S.Q. Chua; Marcus Ang; Quan V Hoang; Chee Wai Wong
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 405. doi:
Axial length changes induced by positive defocus correlate with changes in choroidal blood flow Open Access
Barbara Swiatczak; Giacomo Calzetti; Frank Schaeffel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 406. doi:
Scleral Crosslinking Using Genipin Can Compromise Retinal Structure and Function in Tree Shrew Eyes Open Access
Mustapha El Hamdaoui; Alexander Miles Levy; Aaron Stuber; Christopher A Girkin; Timothy Kraft; Brian C Samuels; Rafael Grytz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 407. doi:
TWO-YEAR EFFECTIVENESS OF A NOVEL MYOPIA MANAGEMENT SPECTACLE LENS WITH FULL-TIME WEARERS Open Access
Joe Rappon; Jay Neitz; Maureen Neitz; Carol Chung; Thomas Walter Chalberg
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 408. doi:
The role of Notch 3 in maintaining retinal vascular stability during aging Open Access
Michael O'Hare; Joseph Arboleda-Velasquez
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 409. doi:
Elevated Vitreous Retinol Binding Protein 3 Concentrations Are Associated with Decreased Vitreous Inflammatory Cytokines, VEGF, and Progression of Diabetic Retinopathy Open Access
Ward Fickweiler; Hyunseok Park; Kyoungmin Park; Tanvi Chokshi; Margalit Mitzner; Devon Robinson; Tahani Boumenna; Yumi Zaitsu; John Gautier; I-Hsien Wu; Jerry Cavallerano; Lloyd Paul Aiello; Jennifer K Sun; George King
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 410. doi:
miRNA 9 regulates endothelial to mesenchymal transition in the retina in diabetes Open Access
Subrata Chakrabarti; Eric Wang; biao Feng
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 411. doi:
Single-nuclei RNA sequencing of the diabetic mouse retina reveals novel insights into the pathophysiology of early diabetic retinal disease Open Access
Mira Menon Sachdeva; Sung-Ung Kang; Shinwon Ha; Dongsan Kim; Kelcy Audra Klein; Fatih Akkentli; Valina L Dawson; Ted M Dawson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 412. doi:
The Role of the STING/Type I IFN Signaling Pathway in Diabetic Retinopathy Open Access
Haitao Liu; Anastasiia Strizhakova; Stacey L Hose; Chao Huang; Pamela Strassburger; Gabriella Widmer; Alan D Proia; Eleonora Lad; Peter Westenskow; Nikolaos Mitrousis; Derrick Feenstra; Debasish Sinha
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 413. doi:
LRG1-driven phenotypic switch in pericytes is an early event in diabetic retinopathy Open Access
Giulia De Rossi; Marlene E Da Vitoria Lobo; John Greenwood; Stephen E Moss
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 414. doi:
REDD1 promotes diabetes-induced retinal inflammation by sustaining GSK3β-dependent NF-κB activation Open Access
Michael D. Dennis; Siddharth Sunilkumar; Allyson Toro; Christopher McCurry; William Miller
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 415. doi:
Adoptive Transfer of Plasmacytoid Dendritic Cells Promotes Allograft Survival in a Murine Allogeneic Corneal Transplantation Open Access
Fangfang Qiu; Brendan Kenyon; Cecilia Chao; Deshea L Harris; Olivia esteireiro; Pedram Hamrah
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 416. doi:
Effect of sCD83 on direct allosensitization after corneal transplantation Open Access
Alfrun Patricia Schönberg; Katrin Peckert-Maier; Karina Hadrian; Matthias Hamdorf; Claus Cursiefen; Elisabeth Zinser; Felix Bock
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 417. doi:
An Acquired Immunostimulatory Function by Type-1 CD103+ Dendritic Cells Promotes Alloimmunity in High-risk Corneal Transplantation Open Access
Tomas Blanco; Hayate Nakagawa; Aytan Musayeva; Hamid Alemi; Thomas H Dohlman; Yihe Chen; Sunil Chauhan; Jia Yin; Reza Dana
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 418. doi:
Galectin-3 modulates monocyte infiltration in the injured cornea by inducing sialyl LewisX expression Open Access
Dina Abusamra; Marina Anastasiou; Noorjahan A Panjwani; Pilar Alcaide; Pablo Argueso
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 419. doi:
Nerve Associated Macrophages in the Cornea are Maintained by IL-34 and are Involved in Mechanosensation Open Access
Sejiro Littleton; Chen Yu; Daniel R Saban
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 420. doi:
Trigeminal Ganglia Sensory Neurons Alter the Expression of Vascular Adhesion Molecules on Endothelial Cells in a Neuropeptide-dependent Fashion Open Access
Pedram Hamrah; Victor G. Sendra; Deshea L Harris; Sudan Puri; Takefumi Yamaguchi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 421. doi:
Ocular surface mast cells delay regression of pathological corneal blood vessels Open Access
WonKyung Cho; Elsayed Elbasiony; Yilin Guan; Aastha Singh; Sharad Mittal; Sunil Chauhan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 422. doi:
Biomarkers from clinic deployable, multiplex, diagnostic test stratifies ocular surface disease and sub-clinical inflammation in patients. Open Access
Sailie Shirodkar; Rohit Shetty; Archana Padmanabhan Nair; Pooja Khamar; Swaminathan Sethu; Arkasubhra Ghosh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 423. doi:
Age-Dependent Perception of Ocular Pain and its Differential Impact on Quality of Life Dimensions Open Access
Leyla Mirzaee; Matteo Posarelli; Pedram Hamrah
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 424. doi:
Risk Factors for Meibomian Gland Morphology Changes in Children Aged 4 to <18 years Open Access
Manisha Parikh; Yi Pang; Lindsay Sicks
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 425. doi:
Ocular Surface Sphingomyelinases, Meibum and Tear Sphingolipids, and Clinical Parameters of Meibomian Gland Dysfunction Open Access
Victor Sanchez; Anat Galor; Katherine Jensen; Koushik Mondal; Nawajes A Mandal
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 426. doi:
The effect of finasteride on dry eye disease Open Access
Brian Jonathan Nguyen; Elana Meer; Angela S Gupta; Gao Jinpeng; Gui-Shuang Ying; Vatinee Y Bunya; Ilaria Macchi; Mina Massaro-Giordano
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 427. doi:
The Relationship Between adherence to a Mediterranean Diet and Dry Eye Disease Open Access
Morten Schjerven Magno; Emily Moschowits; Marie Wangen Beining; Christopher J Hammond; Tor Utheim; Jelle Vehof
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 428. doi:
Phase 2 Study of the Efficacy and Safety of Recombinant Human Nerve Growth Factor (rhNGF) in Patients with Moderate-to-Severe Dry Eye Open Access
Melissa Toyos; David Wirta; John Goosey; Sherif El-Harazi; Flavio Mantelli
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 429. doi:
Targeting Cholesterol Homeostasis Improves Recovery In Experimental Optic Neuritis Open Access
Cheyanne Godwin; Lin Cheng; Jeffrey Anders; Benjamin Elwood; Randy H Kardon; Oliver W Gramlich
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 430. doi:
Novel Autoantibody Models of NMOSD and MOGAD Optic Neuritis Demonstrate Distinct Clinicopathologic Features Open Access
Oliver W Gramlich; Cheyanne Godwin; Benjamin Elwood; Jeffrey Anders; Randy H Kardon; Jeffrey L Bennett
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 431. doi:
The Incidence and Characteristics of Charles Bonnet Syndrome in a Large Cohort of Leber’s Hereditary Optic Neuropathy Patients Open Access
Hong-An Nguyen; Mohammad Kreimei; Eisi Mollanji; Lissa Poincenot; Rustum Karanjia
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 432. doi:
Long-term efficacy and safety of idebenone in patients with LHON in the subacute/dynamic phase: Results from the LEROS study Open Access
Thomas Klopstock; Livia Tomasso; Xavier Llòria
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 433. doi:
The phase III REFLECT trial: efficacy of bilateral gene therapy for Leber hereditary optic neuropathy (LHON) is maintained 2 years post administration Open Access
Patrick Yu-Wai-Man; Nancy Newman; Prem S Subramanian; Mark Moster; An-Guor Wang; Sean Donahue; Bart Leroy; Valerio Carelli; Valerie Biousse; Catherine Vignal-Clermont; Alfredo A Sadun; Gema Fernandez; Elizabeth Fortin; Rudrani Banik; Magali Taiel; Jose Alain Sahel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 434. doi:
3D Structural Analysis of the Optic Nerve Head to Robustly Discriminate Between Optic Disc Drusen and Papilledema Open Access
Michael J A Girard; Satish Kumar Panda; Tin Aung Tun; Raymond Najjar; Tin Aung; Alexandre Thiery; Steffen Hamann; Clare Louise Fraser; Dan Milea
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 435. doi:
Quantifying Spatial Patterns of OCT Total Retinal Thickness (TRT) in Papilledema Over Time using a Deep Learning Variational AutoEncoder Open Access
Wang Jui-Kai; Mona K Garvin; Mark J Kupersmith; Randy H Kardon
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 436. doi:
Intraoperative Intravitreal Bevacizumab Prolongs Survival of Trabeculectomy Blebs at 12 months: The Avastin in Trabeculectomy Study Open Access
Jamie Craig; Sean Mullany; John Landers
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 437. doi:
Comparison of acetylsalicylic acid and mitomycin C in Tenon’s capsule fibroblasts: distinct effects on cytokine-induced myofibroblast activity and implications for glaucoma surgery. Open Access
Anastasiya Vinokurtseva; James Jacob Armstrong; Erica Li; Hong Liu; Cindy Hutnik
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 438. doi:
The effect of amniotic membrane transplantation on trabeculectomy in patients with pseudoexfoliation glaucoma Open Access
Jiwoong Lee; Tae Yeon Kim; Hwa Yeong Kim; Sang Woo Moon
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 439. doi:
High concentration of adrenaline blocks key cell cycle genes and exhibits potent antifibrotic and vasoconstrictor effects in glaucoma surgery Open Access
Cynthia Yu-Wai-Man; Kai Xin Thong; Petru Andriesei; Jia Ng; Pirro G Hysi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 440. doi:
A New Model for Glaucoma Filtering Surgery in Mice Open Access
Jan Tode; Maximilian Binter; Esther Molinski; Stephanie Hempel; Miriam Heider; Carsten Framme; Heiko Fuchs; Philipp Luedtke
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 441. doi:
Preclinical evaluation of RTC-1119, a surface eroding intracameral implant composed entirely of a latanoprost acid prodrug, for long-term intraocular pressure control Open Access
Ike Ahmed; Kyle Battiston; Shadi Taghavi; Hans Fischer; Emily Baldwin; Matthew Statham; Jonathan Day; Adam Daley; Ben Muirhead; Emily Anne Hicks; Jennifer Jing Yuan Tian; Heather Sheardown; Ian Parrag; Wendy Naimark
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 442. doi:
Magnetically actuated glaucoma drainage device for regulating intraocular pressure after implantation Open Access
Inês C.F. Pereira; Hans M. Wyss; Henny J Beckers; Jaap M.J. den Toonder
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 443. doi:
Effect of Supine Position on Episcleral Venous Pressure in Normal Human Eyes using a Portable Electronic Episcleral Venomanometer Open Access
Arash Kazemi; Arthur J Sit
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 444. doi:
Trabecular meshwork exosomes and the extracellular matrix Open Access
Fiona S McDonnell; Bre'Ida J Riddick; Haven Roberts; Nikolai P Skiba; Daniel W Stamer
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 445. doi:
Characterization of Loxl1-knockout-induced elastosis in mice with different genetic backgrounds Open Access
Maria Fernanda Suarez; Heather Schmitt; Kristyn Hake; Megan Kuhn; TeddiJo Watkins; Michael H Elliott; Michael A Hauser; Daniel W Stamer
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 446. doi:
Pharmacokinetics of a Hydrogel-based Nepafenac Intracanalicular Insert in Canines Open Access
Oktay Uzun; Ankita Desai; Sanjani Ray; Chintan Patel; Charles D Blizzard; Peter K Jarrett; Michael Goldstein
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 447. doi:
Physiological variations in intraocular pressure: mathematical modeling outputs versus clinical data from patients with glaucoma and healthy controls Open Access
Maggie Lin; Alon Harris; Giovanna Guidoboni; Damien Coll; Roberto Nunez; Alice Verticchio; Brent A Siesky; Marcela Szopos
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 448. doi:
Mechanistic actions of baicalein in human trabecular meshwork cells Open Access
Hoi-lam Li; Sze Wan Shan; Daniel W Stamer; Henry Ho-lung Chan; Chi-ho To; Thomas Chuen Lam; Chi-wai Do
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 449. doi:
Findings on visual photosensitivity in two phase 1/2 clinical trials of subretinal gene therapy with AGTC-401 and AGTC-402 for CNGB3 and CNGA3 achromatopsia Open Access
Rachel M Huckfeldt; Jason Comander; Mark E Pennesi; Paul Yang; Andreas Lauer; Robert Sisk; Edward Averbukh; Eyal Banin; Ninel Z Gregori; Janet L Davis; Byron L Lam; Christine Nichols Kay; Jessica Ijams Wolfing Morgan; Joseph Carroll; Bright Senyo Ashimatey; Matthew Feinsod
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 450. doi:
PERCEIVE study report: Real-world safety and effectiveness of voretigene neparvovec Open Access
M Dominik Fischer; Rainer Maier; Andrea Suhner; Daniel Stiehl; Christina Fasser; Bart P Leroy
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 451. doi:
Neural plasticity of the human visual system reflects treatment effect in gene therapy for Achromatopsia Open Access
Immanuel Philipp Seitz; Michael Erb; Thomas Ethofer; Andriani Rina; Georgios Keliris; M Dominik Fischer; Karl-Ulrich Bartz-Schmidt
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 452. doi:
Long-term safety and efficacy of sepofarsen in a Ph1b/2 INSIGHT extension trial in CEP290-associated Leber congenital amaurosis (LCA10) Open Access
Stephen R Russell; Arlene V Drack; Artur V Cideciyan; Samuel G. Jacobson; Bart P Leroy; Caroline Van Cauwenbergh; Michael Schwartz; Aniz Girach
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 453. doi:
Long-term follow up of gene therapy for NPHP5-LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years Open Access
William A Beltran; Artur V Cideciyan; Ana Ripolles-Garcia; Valerie L Dufour; Yu Sato; Alexa Gray; Malgorzata Swider; Sanford L Boye; William W Hauswirth; Samuel G. Jacobson; Gustavo D Aguirre
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 454. doi:
Worldwide multicenter ocular imaging study (EyeConic) to identify patients eligible for cone-based optogenetics therapy Open Access
Lucas Janeschitz-Kriegl; Giacomo Calzetti; Michel Michaelides; Jose Alain Sahel; Zoltán Nagy; Katarina Stingl; Jin Zi-Bing; Jacque L Duncan; Eyal Banin; Byron L Lam; Michalis Georgiou; Boris Rosin; Viktória Szabo; Potyra Rosa; Bence György; Hendrik P Scholl
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 455. doi:
Classification and growth rate of retinal atrophy after voretigene neparvovec-rzyl for RPE65-mediated retinal dystrophy Open Access
Nikhil Bommakanti; Benjamin Young; Robert Sisk; Audina M. Berrocal; Jacque L Duncan; Benjamin Bakall; Marc Mathias; Aaron Nagiel; Cagri G Besirli
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 456. doi:
CFAP418 functions in membrane lipid homeostasis through binding phosphatidic acid and cardiolipin during photoreceptor ciliogenesis Open Access
Jun Yang; Anna Clark; Dongmei Yu; Daniel Zhu; Grace Neiswanger
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 457. doi:
Pharmacological Lowering Of Ceramide Buildup In AdipoR1-/- Mice Increases Photoreceptor Survival And Improves Vision Open Access
Dominik Lewandowski; Andrzej Foik; Roman Smidak; Elliot H Choi; Jianye Zhang; Thanh Hoang; Aleksander Tworak; Susie Suh; Zhiqian Dong; Antonio F.M. Pinto; Emily Tom; Seth Blackshaw; David Lyon; Dorota Skowronska-Krawczyk; Marcin Tabaka; Krzysztof Palczewski
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 458. doi:
Anti-ceramide immunotherapy for diabetic retinopathy Open Access
Tim Florian Dorweiler; Peter Nolan; Richard N. Kolesnick; Julia V Busik
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 459. doi:
The interplay of luminance and genetics in the retinopathy induced by the dominant RPE65 mutation Open Access
Wenjing Wu; Yusuke Takahashi; Xiang Ma; Gennadiy P Moiseyev; Jian-Xing Ma
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 460. doi:
Characterization of retinal architecture in a systemic HL/EL double knockout mouse model Open Access
Rohini M Nair; Ying Song; Brent A Bell; Kevin Zhang; Daniel J Rader; Joshua L Dunaief; Venkata R M Chavali
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 461. doi:
Cell Autonomous Lipid Handling Defects in Stargardt iPS Cell-Derived Retinal Pigment Epithelium Cells Open Access
Mitra Farnoodian-Tedrick; Devika Bose; Indumathi Mariappan; Maria M Campos; Rafael Villasmil; Kapil Bharti
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 462. doi:
Identification of disease associated endpoints in a mouse model exhibiting AMD-like pathology with age. Open Access
Mayur Choudhary; Goldis Malek
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 463. doi:
Thrombospondin-1 p.R1034 missense alleles cause congenital glaucoma with variable expressivity by inducing extracellular protein aggregation Open Access
Haojie Fu; Owen Siggs; Lachlan Knight; Sandra E Staffieri; Jonathan B Ruddle; Amy E Birsner; Edward Ryan Collantes; Jamie Craig; Janey L Wiggs; Robert J D'Amato
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 805. doi:
Loss of cathepsin K function in trabecular meshwork induces actin polymerization and apoptosis Open Access
Padmanabhan P Pattabiraman; Avinash Soundararajan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 806. doi:
Age-related functional vision loss in Sphingosine-1-phosphate receptor 3 knockout mouse Open Access
Sanjoy K Bhattacharya; Varun Krishnan; Sean D Meehan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 807. doi:
AI-based Clinical Assessment of Optic Nerve Head Robustness from 3D Optical Coherence Tomography Imaging Open Access
Fabian Albert Braeu; Thanadet Chuangsuwanich; Tin A. Tun; Alexandre Thiery; George Barbastathis; Tin Aung; Michael J A Girard
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 808. doi:
Upregulated YAP activity and histone acetylation modulate glaucomatous trabecular meshwork cell dysfunction Open Access
Haiyan Li; Daniel W Stamer; Preethi S Ganapathy; Samuel Herberg
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 809. doi:
Glaucomatous stressors drive Schlemm’s canal cell pathobiology via elevated YAP activity Open Access
Samuel Herberg; Haiyan Li; Megan Kuhn; William Daniel Stamer; Preethi S Ganapathy
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 810. doi:
A novel method to determine axon-level IOP-induced insult Open Access
Manik Bansal; Fuqiang Zhong; Yi Hua; Bingrui Wang; Juan Reynaud; Brad Fortune; Ian Sigal
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 811. doi:
Presence and development of diabetic retinopathy in the Danish Registry of Diabetic Retinopathy. Open Access
Jakob Grauslund; Frederik Pedersen; Nis Andersen; Jens Andresen; Toke Bek; Morten la Cour; Sebastian Dinesen; Javad Hajari; Kurt Højlund; Caroline Laugesen; Ryo Kawasaki; Sören Möller; Katja Schielke; Anne Thykjær; Lonny Stokholm
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 812. doi:
Predicting progression to proliferative diabetic retinopathy Open Access
Cathy Sun; Yian Guo; Sean Yonamine
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 813. doi:
Characterising individuals with retinopathy from retinal image grading data in UK Biobank Open Access
Alasdair Warwick; Barbra Hamill; Katie Curran; Anthony Khawaja; Andrew J Lotery; Paul Foster; Konstantinos Balaskas; Michael Joseph Quinn; Savita Madhusudhan; Alan Sproule; Sophie Leach; Daniela Florea; Muldrew Alyson; Laura Cushley; Graham Young; Tunde Peto
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 814. doi:
Thickness of ten retinal layers from macular optical coherence tomography (OCT) volume scans in participants with and without diabetes and their relationship with glucose metabolism Open Access
Yangjiani Li; Franziska G. Rauscher; Mengyu Wang; Mohammad Eslami; Jennifer K Sun; Konstantina Sampani; Kerstin Wirkner; Markus Loeffler; Michael Stumvoll; Joachim Thiery; Anke Tönjes; Christoph Engel; Toralf Kirsten; Thomas Ebert; Tobias Elze
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 815. doi:
Development of a New Patient-Reported Outcome Instrument to Assess Diabetic Retinopathy Treatment Experiences Open Access
Diana V Do; Steven Sherman; Adele Levine; Patrick Marquis; Christopher Hartford; Rohini Rao; Diana Rofail
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 816. doi:
Diabetic Retinopathy and Chronic Kidney Disease: Associations and Comorbidities in a Large Diabetic Population: The Tongren Health Care Study Open Access
Ya Xing Wang; Can Can Xue; Li Qin Gao; Chun Zhang; Dong Ning Chen; Jost Jonas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 817. doi:
Transition probabilities of diabetic retinopathy and death in an Asian population with diabetes Open Access
Charumathi Sabanayagam; Feng He; Haslina Hamzah; Tien Yin Wong; Ching-Yu Cheng; Gavin Tan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 818. doi:
Selective autophagy regulates limbal epithelial differentiation via controlling Notch1 protein degradation Open Access
Han Peng; Nihal Kaplan; Min Liu; Wending Yang; Robert M Lavker
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 819. doi:
Comparative stromal cell therapy for corneal scarring with corneal stromal stem cells versus keratocytes Open Access
Vishal Jhanji; Mithun Santra; Gary Hin-Fai Yam
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 820. doi:
Elimination of senescent cells protects against angiogenesis and corneal opacity at the ocular surface of old mice Open Access
Koji Kitazawa; Kohsaku Numa; Pierre-Yves Desprez; Chie Sotozono; Judith Campisi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 821. doi:
Stimulation of Trigeminal Ganglion Neurons by Capsaicin Affects Corneal Leukocyte Migration Via Alterations in Neuropeptide Expression Open Access
Sudan Puri; Brendan Kenyon; Victor G. Sendra; Deshea L Harris; Pedram Hamrah
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 822. doi:
Novel PAX6 variants and their roles in corneal epithelial regulation and homeostasis Open Access
Vinay Kumar Pulimamidi; Savitri Maddileti; Indumathi Mariappan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 823. doi:
A single cell transcriptome analysis unravels the heterogeneity of primary cultured human corneal endothelial cells Open Access
Pere Català; Nathalie Groen; Rudy M.M.A. Nuijts; Vanessa L.S. LaPointe; Mor M. Dickman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 824. doi:
Wnt signaling pathway in the human limbus: a comprehensive mapping by single mRNA detection Open Access
Clemence Bonnet; Maxime Ruiz; Sheyla Gonzalez; Chi-Hong Tseng; Jean-Louis Bourges; Francine F Behar-Cohen; Sophie Xiaohui Deng
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 825. doi:
Assessment of Alternative Tests for the ICD-10 Glaucoma Severity Score Open Access
Ari Leshno; Emmanouil (Manos) Tsamis; Noga Harizman; Qing Wang; Sol La Bruna; Anvit Rai; Carlos G DeMoraes; George A Cioffi; Jeffrey M Liebmann; Donald C Hood
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 826. doi:
Association Between Macular OCT/OCTA Parameters and Visual Acuity in Glaucoma Open Access
Jo-Hsuan Wu; Sasan Moghimi; Takashi Nishida; Vahid Mohammadzadeh; Alireza Kamalipour; Linda M Zangwill; Robert N Weinreb
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 827. doi:
Structural and Functional Assessment of Glaucoma Progression in Patients with Boston Keratoprosthesis Type 1 Open Access
Alexandra Castillejos; Chhavi Saini; James Chodosh; Lucy Q. Shen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 828. doi:
Predicting Deep Perimetric Defects from Retinal Nerve Fiber Layer (RNFL) Reflectance at the Optic Disc Open Access
William H Swanson; Muhammed Saad M Alluwimi; Rizwan Malik; Brett King
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 829. doi:
Longitudinal changes in structural and functional measurements along the glaucoma severity spectrum Open Access
Maria de los Angeles Ramos Cadena; Gadi Wollstein; TingFang Lee; Jiyuan Hu; Fabio Lavinsky; Ian Conner; Joel S Schuman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 830. doi:
An automated, structure-function method for detecting progression of glaucoma Open Access
Emmanouil (Manos) Tsamis; Sol La Bruna; Ari Leshno; Anvit Rai; George A Cioffi; Jeffrey M Liebmann; Carlos G DeMoraes; Donald C Hood
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 831. doi:
Combining OCT and OCT-Angiography Longitudinal Measurements for the Prediction of Visual Field Progression in Glaucoma with Artificial Intelligence Open Access
Alireza Kamalipour; Sasan Moghimi; Pooya Khosravi; Vahid Mohammadzadeh; Takashi Nishida; Eleonora Micheletti; Jo-Hsuan Wu; Golnoush Mahmoudinezhad; Mark Christopher; Linda Zangwill; Tara Javidi; Robert N Weinreb
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 832. doi:
Canonical and non-canonical EphA2 signaling in the lens Open Access
Catherine Cheng
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 833. doi:
Non-muscle myosin IIA regulates lens epithelial cell alignment during fiber cell differentiation Open Access
Sadia Tamanna Islam; Catherine Cheng; Justin Parreno; Velia M Fowler
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 834. doi:
Vitreous exposure increases global chromatin accessibility in cis-regulatory elements in lens epithelial explants as they undergo fiber cell differentiation Open Access
Anil Upreti; Jared Austin Tangeman; Brad D. Wagner; Tycho Jupiter Jaquish; Raye Palko; Cameron Gantz; Michael L Robinson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 835. doi:
Sumoylated Pax6 Regulates Lens Stalk Regression During Lens Development Open Access
David W Li; Jialing Fu; Fangyuan Liu; Shuyu Zheng; Yan Wang; Jingmiao Wang; yuan xiao; Jiawen Xiang; Yuwen Gan; Xingmiao Liang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 836. doi:
ROLE OF CHROMATIN AND DNA METHYLATION IN MOUSE LENS DIFFERENTIATION Open Access
Ales Cvekl; William Chang; Yilin Zhao; Qing Xie; Masako Suzuki; Deyou Zheng
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 837. doi:
Gene Silencing by DNA Methylation Predicts Chromatin Regions and Transcription Factors Required for Lens Differentiation Open Access
Joshua Disatham; Lisa A Brennan; Xiaodong Jiao; Zhiwei Ma; James F Hejtmancik; Marc Kantorow
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 838. doi:
High-throughput single-cell RNA sequencing of the developing lens Open Access
Deepti Anand; Atul Kakrana; Rosanne Skinner; Clark Bloomer; Irfan Saadi; Salil Anil Lachke
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 839. doi:
Hazard perception in bioptic drivers Open Access
Rebecca A Deffler; San-San Cooley; Thomas W Raasch; Bradley E Dougherty
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 840. doi:
Hazard Warning Modalities and Timing Thresholds for Drivers with Impaired Contrast Sensitivity Open Access
Jing Xu; Abbie Hutton; Alex R Bowers
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 841. doi:
Fall-related longitudinal changes in gait among glaucoma patients Open Access
José Gustavo Vargas; Aleksandra Mihailovic; Pradeep Y Ramulu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 842. doi:
Relation Between Real-World Home Physical Activities and Cadence with Home Environment in Glaucoma Patients. Open Access
Seema Banerjee; Aleksandra Mihailovic; Pradeep Y Ramulu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 843. doi:
Effect of low light levels and target contrast on stepping accuracy in older adults with age-related macular degeneration Open Access
Mahesh Kumar Dev; Alex A Black; Damian Cuda; Joanne M Wood
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 844. doi:
Pilot testing of a pedestrian collision detection test for field expansion devices Open Access
Alex R Bowers; Alex D Hwang; Jae-Hyun Jung; Sailaja Manda; Sandhya Shekar; Eli Peli
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 845. doi:
Head Scanning of Patients with Homonymous Hemianopia at Street Crossings Open Access
Shrinivas Pundlik; Ayush Kumar; Eli Peli; Kevin Houston; Gang Luo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 846. doi:
Phase-based optoretinography with clinical-grade OCT using tissue velocity Open Access
Kari V Vienola; Robert J Zawadzki; Ravi S Jonnal
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 847. doi:
Deep-learning Embedding of Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) for Macular Telangiectasia Type 2 and Age-Related Macular Degeneration Open Access
Julia Owen; Lydia Sauer; Paul S Bernstein; Cecilia S Lee; Aaron Y Lee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 849. doi:
Federated Deep Learning for Classifying Glaucomatous Optic Neuropathy from Optical Coherence Tomography Volumetric Scans: A Privacy-preserving Multi-national Study Open Access
Anran RAN; Xi Wang; Poemen P Chan; Noel C Chan; Oi Man Mandy Wong; Hon-Wah Yung; Robert T. Chang; Suria S. Mannil; Yih Chung Tham; Ching-Yu Cheng; Pheng-Ann Heng; Clement C. Tham; Carol Yim-lui Cheung
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 850. doi:
Dynamic OCT with retinal pigment epithelium-choroid tissue ex-vivo Open Access
Yoko Miura; Tabea Kohlfaerber; Noriko Kubota; Martin Ahrens; Mario Pieper; Peter König; Gereon Hüttmann; Hinnerk Schulz-Hildebrandt
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 851. doi:
Segmentation-Free OCT-Volume-Based Deep Learning Model Improves Point-Wise Visual Field Threshold Estimation Open Access
Zhiqi Chen; Eitan Shemuelian; Lei Zheng; Gadi Wollstein; Yao Wang; Hiroshi Ishikawa; Joel S Schuman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 852. doi:
Volumetric evaluation of choroidal depigmentation in the eyes with Vogt–Koyanagi–Harada disease using polarization-sensitive OCT Open Access
Masahiro Miura; Shuichi Makita; Yoshiaki Yasuno; Shinnosuke Azuma; Toshihiro Mino; Tatsuo Yamaguchi; Takuya Iwasaki; Rei Nemoto; Hiroyuki Shimizu; Hiroshi Goto
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 853. doi:
Transcriptome analysis of AMD-like pathology in aged BALB/c mice following systemic neonatal murine cytomegalovirus infection Open Access
Ming Zhang; Jinxian Xu; Xinyan Zhang; Brendan Marshall
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 854. doi:
Lipid peroxidation and iron accumulation induced ferroptosis in bacterial endophthalmitis Open Access
ZEESHAN AHMAD; Sukhvinder Singh; Xavier Walker; Robert Wright; Ashok Kumar
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 855. doi:
Immune profile in patients with COVID-19 associated rhino-orbital-cerebral mucormycosis Open Access
Bhavya Gorimanipalli; Archana Padmanabhan Nair; Rohit Shetty; Sanjay Mahajan; Sushma Ananthakrishna; Anjali Kiran; Moupia Goswami; Varshitha Hemanth Vasanthapuram; Raksha Rao; Gairik Kundu; Ajay Krishna Murthy; Gagan Dudeja; Roshmi Gupta; Swaminathan Sethu; Arkasubhra Ghosh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 856. doi:
Single cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes. Open Access
Jahan Alam; Ghasem Yazdanpanah; Nicholas Borcherding; Rinki Ratnapriya; Cintia S De Paiva; De-Quan Li; Stephen C Pflugfelder
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 857. doi:
Characterization and proteome profiling of extracellular vesicles in a murine model of Pseudomonas aeruginosa endophthalmitis Open Access
Dhanwini Rudraprasad; Aravind Kumar Rengan; Milind Neelkanth Naik; Joveeta Joseph Ruben
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 858. doi:
Host factors related to SARS-CoV2 infection in the human eye and prophylaxis thereof Open Access
Sharon DSouza; Vishnu Suresh Babu; Trailokyanath Panigrahi; Rohit Shetty; Pooja Khamar; Poornachandra B; Swaminathan Sethu; Arkasubhra Ghosh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 859. doi:
Role of macrophage sub-populations in ocular HSV-1 infection. Open Access
Ujjaldeep Jaggi; Harry Matundan; Homayon Ghiasi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 860. doi:
Nuclear localized HDAC4 increases retinal ganglion cell survival after optic nerve crush injury Open Access
Ying Zhu; Jinliang Li; Minjuan Bian; Xin Xia; Michael Nahmou; Catalina Sun; Jeffrey L Goldberg; Michael Kapiloff
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 861. doi:
Spp1 drives retinal ganglion cell resiliency in glaucomatous neuropathy Open Access
Mengya Zhao; Kenichi Toma; Benyam Kinde; Yang Hu; Ying Han; Xin Duan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 862. doi:
Retinal ganglion cell specific deletion of arginase-2 preserves visual function after optic nerve crush Open Access
Syed Adeel Zaidi; zhimin Xu; Tahira Lemtalsi; Abdelrahman Fouda; R. William Caldwell; Ruth B Caldwell
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 863. doi:
REV-ERBα regulates retinal function and protects against retinal degeneration in experimental retinitis pigmentosa Open Access
Felix Yemanyi; Chi-Hsiu Liu; Shuo Huang; Kiran Bora; Meenakshi Maurya; Alexandra K. Blomfield; Zhongjie Fu; James Akula; Jing Chen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 864. doi:
Intranasally Administered Insulin Reaches the Retina and Choriocapillaris in Rats Open Access
Sally Ong; Jenna Rae Gustafson; Joanne Konstantopoulos; Suzanne Craft; Rebecca M Sappington
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 865. doi:
Retinal ganglion cell resilience to injury indicated by cytoplasmic [Ca2+] levels Open Access
Sean McCracken; Philip Williams
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 866. doi:
Dissecting transcriptional networks that regulate retinal ganglion cell survival and axon regeneration after optic nerve injury Open Access
Kimberly A Wong; Tanisha Martheswaran; John Msaddi; Derek Stuart Welsbie; Larry Benowitz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 867. doi:
Metabolic ecosystems exist between retina and RPE in vivo Open Access
Daniel Hass; Elizabeth Giering; Celia Bisbach; James B Hurley
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 868. doi:
Peroxisomal β-oxidation deficiency in RPE leads to progressive RPE dedifferentiation and retinal degeneration Open Access
Sai Kocherlakota; Yannick Das; Danielle Swinkels; Debasish Sinha; Frédéric Vaz; Marc Fransen; Myriam Baes
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 869. doi:
The serine biosynthetic enzyme, PHGDH, is essential for retinal health Open Access
Marin Gantner; Regis Fallon; Yoichiro Ideguchi; Caleb Bates; Michal Handzlik; Martina Wallace; Christian Metallo; Martin Friedlander
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 870. doi:
Three-dimensional reconstruction of human retinal pigment epithelium (RPE) permits a novel view of the RPE – photoreceptor outer segment (OS) interface Open Access
Andreas Pollreisz; Aleksandra Sedova; Maximilian Lindell; Zachary Arsenault; Orin Packer; Deepayan Kar; Yeon Jin Kim; Kenneth R Sloan; Ursula Schmidt-Erfurth; Mike Marsh; Christine A Curcio; Dennis M Dacey
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 871. doi:
Transmembrane protein 135 regulates lipid metabolism in mouse eyecup Open Access
Akihiro Ikeda; Michael Landowski; Vijesh Bhute; Tetsuya Takimoto; Samuel Grindel; Pawan K Shahi; Bikash R Pattnaik; Sakae Ikeda
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 872. doi:
Dimethyl fumarate blocks TNFα-driven inflammation and metabolic rewiring in retinal pigment epithelial cells Open Access
Daisy Y Shu; Tessa C. Fitch; Scott I. Frank; Erik Russell Butcher; Margarete Karg; Siwei Cai; Rishi Shah; Deviprasad Gollapalli; Magali Saint-Geniez
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 873. doi:
Dysregulation of Tricarboxylic Acid (TCA) Cycle Activity and Lipid Metabolism in Preclinical Models of Retinitis Pigmentosa Open Access
Katherine J. Wert; Ashley Rowe; Ruth Gordillo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 874. doi:
Individualized mesopic and dark-adapted fundus-controlled perimetry: Longitudinal changes in retinal sensitivity at the border of geographic atrophy. Open Access
Monika Fleckenstein; Leon Alexander von der Emde; Frank G Holz; Steffen Schmitz-Valckenberg; Maximilian Pfau
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 875. doi:
Investigation of intermediate AMD with MAIA microperimetry metrics by the PINNACLE Consortium Open Access
Philipp Anders; Ghislaine L Traber; Ahmed M Hagag; Sophie Riedl; Lars Fritsche; Daniel Rueckert; Ursula Schmidt-Erfurth; Sobha Sivaprasad; Andrew J Lotery; Hendrik P Scholl
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 876. doi:
Optical Coherence Tomography (OCT) Features Associated with Three-Year Changes in Microperimetry Sensitivity in Age-related Macular Degeneration (AMD) Open Access
Gregory Tsougranis; Kevin Milton Mendez; Ines Lains; Archana Nigalye; Raviv Katz; Thomas Koch; Jessica Lasky-Su; Ivana K Kim; Demetrios G. Vavvas; John B Miller; Joan W Miller; Deeba Husain
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 877. doi:
A Conceptual Framework for Visual Function Impairment from Normal Aging to Early and Intermediate AMD: ALSTAR2 Cross-sectional Results Open Access
Cynthia Owsley; Thomas A. Swain; Gerald McGwin; Mark Clark; Jason Crosson; Christine A Curcio
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 878. doi:
Mesopic and Scotopic Light Sensitivity Loss Associated with Intraretinal Hyperreflective Foci in Age-related Macular Degeneration Open Access
Xiaolin Wang; Yuhua Zhang; Srinivas R Sadda; David Sarraf; Michael S Ip; Giulia Corradetti; Ruixue Liu; Shin Kadomoto; Sujin Hoshi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 879. doi:
Comparison of visual function in structurally defined sub-phenotypes of intermediate AMD: A MACUSTAR study report Open Access
Hannah M P Dunbar; Marlene Sassmannshausen; Charlotte Behning; Sarah Thiele; Alison Binns; Bethany Elora Higgins; Jan Henrik Terheyden; Adnan Tufail; Sergio Leal; Nadia Zakaria; Frank G Holz; Matthias C Schmid; Robert P Finger; David P. Crabb; Steffen Schmitz-Valckenberg; Ulrich F O Luhmann
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 880. doi:
Cross-Sectional Study Comparing Cone Function in Participants with Intermediate Age-Related Macular Degeneration (iAMD) and in Participants with iAMD and Non-Foveal Nascent Geographic Atr... Open Access
Karl G Csaky
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 881. doi:
Fixation Stability for Emmetropic and Myopic Patients as a Function of the Target's Frequency Content Open Access
Pablo De Gracia; Azra Wazir; Zachary Goodman; Emily Ong
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 882. doi:
Effect of Stimuli Depth on Static and Dynamic Accommodation Responses in Young Children Open Access
Kristen L Kerber; Ashutosh Jnawali; Fuensanta A Vera-Diaz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 883. doi:
Two-years evolution of two-dimensional peripheral refraction in children Open Access
Zhenghua Lin; Weizhong Lan; Longbo Wen; Zhiwei Luo; Zhikuan Yang; Pablo Artal
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 884. doi:
Effect of Peripheral Optical Quality in Accommodation Responses of Young Children Open Access
Fuensanta A Vera-Diaz; Ashutosh Jnawali; Kristen L Kerber; Peter J Bex
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 885. doi:
Localized peripheral choroidal response to signed defocus with and without native aberration Open Access
Dibyendu Pusti; Geunyoung Yoon
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 886. doi:
The diurnal relationship of axial length and choroidal thickness in winter and summer. Open Access
Nickolai Nilsen; Hilde Rogeberg Pedersen; Lene A. Hagen; J.Gilson Stuart; Rigmor C Baraas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 887. doi:
Internal optics failed to compensate for increased corneal astigmatism in myopic children over a 2-year period Open Access
Tsz Wing Leung; Rachel Ka-man Chun; Yuet-ting Li; Chi-ho To; Chea-Su Kee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 888. doi:
Safety, efficacy and delivery of multiple nucleoside analogs via drug encapsulated carbon (DECON) based sustained drug release platform. Open Access
Tejabhiram Yadavalli; Joshua Ames; David Wu; Benjamin Ramirez; Navya Bellamkonda; Deepak Shukla
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1093. doi:
Comparison of topical Nomacopan, a dual Complement and leukotriene LTB4 inhibitor, with dexamethasone in downregulating experimental allergic conjunctival disease (EAC) Open Access
Virginia L Calder; Malihe Eskandarpour; Miles Nunn; Wynne Weston-Davies
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1094. doi:
Adenosine treatment ameliorates bacterial endophthalmitis by promoting antimicrobial activity and inhibiting inflammatory milieu Open Access
Sukhvinder Singh; ZEESHAN AHMAD; Susmita Das; Ashok Kumar
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1095. doi:
Carbohydrate restriction preserves visual acuity and motor function in a mouse model of autoimmune demyelination Open Access
Scott Matthew Plafker; Katarzyna Zyla-Jackson; Dorothy Walton; Kendra Plafker; Susan Kovats; Richard Steve Brush; Martin-Paul Gameli Agbaga
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1096. doi:
Systemic Administration of Acazicolcept (ALPN-101), a Dual ICOS/CD28 Antagonist, Suppresses Ocular Inflammation in Rat Experimental Autoimmune Uveitis Open Access
Kathryn L Pepple; Katherine Lewis; Leslie Wilson; Lawrence Evans; Stacey Dillon
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1097. doi:
The role of antiseptic prophylaxis before intravitreal injections: a novel ocular spray containing Biosecur citrus extract for the reduction of preoperative microbial load Open Access
Lorenzo Ferro Desideri; Giuseppe Giannaccare; Chiara Del Noce; Davide Camposampiero; Diego Ponzin; Marco Pellegrini; Vincenzo Scorcia; Carlo Enrico Traverso; Aldo Vagge
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1098. doi:
Reduced tear Thrombospondin-1/Matrix Metalloproteinase 9 ratio can aid diagnosing Sjögren’s syndrome related ocular surface inflammation. Open Access
Sharmila Masli; Esen K Akpek
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1099. doi:
Emmetropization is Associated with a Modified Inflammatory Response in the Eye Open Access
Jody A Summers; Diana Soriano; Elizabeth Martinez
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1100. doi:
Effects of the spectral energy distribution of ambient lighting on L-, M- and S-cone abundancies and emmetropization in the chicken Open Access
Sandra Gisbert Martinez; Siegfried Wahl; Frank Schaeffel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1101. doi:
Blue Light Rearing Does Not Affect In Vivo Retinal Function in Infant Rhesus Monkeys Open Access
Linjiang Lou; Laura J Frishman; Krista M Beach; Li-Fang Hung; Zhihui She; Earl L Smith; Lisa A Ostrin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1102. doi:
Form deprivation (FD) and exogenous all-trans retinoic acid (atRA) result in similar myopigenesis and scleral phenotypes in mice Open Access
Dillon Brown; Michael Kowalski; Quinn Paulus; Jianshi Yu; Praveen Kumar; Maureen A Kane; Jay Patel; C Ross Ethier; Machelle T Pardue
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1103. doi:
Differences in mRNA to Protein Expression Levels in a Spontaneous Myopia Guinea-Pig Model Open Access
Liqin Jiang; Quan V Hoang; Joanna M. Fianza Busoy; Minni Chua; Noel A Brennan; Veluchamy A. BARATHI
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1104. doi:
High Myopia Induced by Bilateral Form Deprivation Is Highly Synchronized in Both Eyes of Chickens: a pilot study Open Access
Byung Soo Kang; Tsz Wing Leung; Sonal Aswin Vyas; Chea-Su Kee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1105. doi:
Optogenetics in the clinic: safety and efficacy updates on the phase 1/2 clinical trial PIONEER Open Access
Jose Alain Sahel; Isabelle S Audo; Elise Boulanger-Scemama; Chloé Pagot; Angelo Arleo; Joseph N Martel; Simona Degli Esposti; Alexandre Delaux; Jean-Baptiste de Saint Aubert; Caroline de Montleau; Emmanuel Gutman; Jens Duebel; Serge Picaud; Deniz Dalkara; Magali Taiel; Botond Roska
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1106. doi:
Successful late-stage disease treatment of P23H human RHO (hRHO) using ARCUS nuclease gene editing in a pig model of Autosomal Dominant Retinitis Pigmentosa (adRP) Open Access
Archana Jalligampala; Jennifer M. Noel; Olivia Noelle Jacobs; Alec Lynn Bradley; Wei Wang; Maha Haleem Jabbar; Nazarul Hasan; Joseph Prestigiacomo; Jeff Smith; Victor Bartsevich; Kristi Viles; Derek Jantz; Maureen Ann McCall
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1107. doi:
Gene augmentation therapy restores vision in a CaBP4-mutant canine model of cone-rod synaptic disorder Open Access
Billie Beckwith-Cohen; Paige A Winkler; Laurence M Occelli; Kelian Sun; Fabiano Montiani-Ferreira; Luis Felipe Marinho; Amy Lee; Maciej Parys; vilma Yuzbasiyan-Gurkan; William W Hauswirth; Simon Petersen-Jones
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1108. doi:
Intravitreal Cerliponase alfa for the treatment of CLN2 type Batten Disease related retinal dystrophy: A first in man report of ocular enzyme replacement Open Access
James Wawrzynski; Paul Gissen; Richard Bowman; Rebecca Bower; Chin Gan; Louise Harding; Amanda Mortensen; Dorothy Thompson; Robert Henderson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1109. doi:
Development of Dual-PCDH15 AAV Gene Therapy for Usher Syndrome Type 1F Blindness and Deafness Open Access
Maryna Ivanchenko; Daniel Hathaway; Eric Mulhall; Mantian Wang; Alex Klein; Yaqiao Li; Bence György; David Corey
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1110. doi:
STK-002, an Antisense Oligonucleotide (ASO) for the Treatment of Autosomal Dominant Optic Atrophy (ADOA), is Taken Up by Retinal Ganglion Cells (RGC) and Upregulates OPA-1 Protein Express... Open Access
Karen Anderson; Aditya Venkatesh; Taylor McKenty; Deidre Slate; Qian Lin; Shobha Ravipaty; Sarah Jacobson; Anne Christiansen; Radhia Benmohamed; Jeff Hoger; Gene Liau
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1111. doi:
Gene therapy rescues photoreceptor function, morphology and survival in a pre-clinical model of CDHR1-associated retinal degeneration Open Access
Imran H Yusuf; Michelle E. McClements; Robert E MacLaren; Peter Charbel Issa
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1112. doi:
Exploring the survival of transplanted hiPSC-derived photoreceptors in the 13-lined ground squirrel Open Access
Ching Tzu Yu; Sangeetha Kandoi; Ramesh Periasamy; Hannah M Follett; Phyllis Summerfelt; Chloe Guillaume; Owen Bowie; Nicole Manfredonia; Dana Merriman; Thomas B Connor; Daniel M Lipinski; Joseph Carroll; Deepak A Lamba
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1113. doi:
Gene therapy rescues cone function in rhesus macaques with PDE6C cone disorder Open Access
Ala Moshiri; Tawfik Issa; Antonio Lopez; Sangwan Park; Jeffrey Rogers; Rui Chen; Eliza Bliss-Moreau; Sara M Thomasy; Tim Stout
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1114. doi:
Donor-host interactions support incorporation, polarization and maturation of human photoreceptors transplanted into a cone-degeneration mouse model Open Access
Karen Tessmer; Sylvia Jane Gasparini; Miriam Reh; Stephanie Wieneke; Madalena Carido; Manuela Völkner; Oliver Borsch; Anka Swiersy; Marta Zuzic; Olivier Goureau; Thomas Kurth; Volker Busskamp; Günther Zeck; Mike O Karl; Marius Ader
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1115. doi:
Increasing the amount of template favors HDR mediated DSB repair in photoreceptors in vivo following AAV mediated gene transfer Open Access
Knut Stieger; Michelle Knapp; David Götzmann; Annabella Janise-Libawski; Bettina Gill; Bärbel Fühler; Tobias Wimmer; Brigitte Müller
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1116. doi:
Masking the “eat me” signal drastically increases the short-term survival of donor human retinal ganglion cells after xenotransplantation Open Access
Monichan Hayes Phay; Sophia Grace Bauer; Petr Y Baranov
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1117. doi:
Stem cell transplantation for treatment of retinal ganglion cell loss in Glaucoma Open Access
Venkata R M Chavali; Vrathasha Vrathasha; Jie He; Yingrui Liu; Sergei S Nikonov; Brent A Bell; Katherine E. Uyhazi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1118. doi:
Intercellular material transfer following retinal ganglion cell transplantation Open Access
Kevin Yang Zhang; Erika Antuanette Aguzzi; Arumugam Nagalingam; Casey Keuthan; Xiaoli Chang; Donald J Zack; Thomas Vincent Johnson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1119. doi:
Histatin Improves Corneal Wound Healing in a Rabbit Model of Surgical Keratectomy Open Access
James Burke; Rozemarijn S Verhoeven; Rhett Schiffman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1120. doi:
Wnt Signaling Regulates Cornea Wound Healing Open Access
Wentao Liang; Jian-Xing Ma
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1121. doi:
Dual epigenetic regulation of WNT5A in diabetic corneal epithelial wound healing Open Access
Ruchi Shah; Tanya M Spektor; Vasu Punj; Hui Ding; Rameshwar Patil; Sue Turjman; Sean Ghiam; Steven T Chun; Cynthia Amador; Dan J Weisenberger; Yaron S Rabinowitz; Ezra Maguen; Mehrnoosh Saghizadeh; Julia Y Ljubimova; Andrei A Kramerov; Alexander V Ljubimov
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1122. doi:
Mast cells augment neutrophil activation and their secretion of tissue-damaging factor Open Access
Elsayed Elbasiony; WonKyung Cho; Yilin Guan; Aastha Singh; Sharad Mittal; Sunil Chauhan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1123. doi:
IGFBP-3 regulates metabolic activity and mitochondrial morphology through a biphasic response in corneal epithelial cells during hyperosmolar stress Open Access
Whitney l Stuard; Melis Kabaalioğlu Guner; Danielle M Robertson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1124. doi:
Glycogene expression profile of human limbal epithelial cells with distinct clonogenic potential. Open Access
Pablo Argueso; Damien Guindolet; Ashley M. Woodward; Eric Gabison
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1125. doi:
Delineating goblet cell metaplasia in a murine model of limbal stem cell deficiency Open Access
Nick Di Girolamo; Richard Zhang; Elvis Pandzic; Mingxia Sun; Vivien Jane Coulson-Thomas; mijeong Park
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1126. doi:
PIEZO1 and PIEZO2 pathogenic variants identified in primary congenital glaucoma Open Access
Terri L Young; Kristina Whisenhunt; Sean Martin; Stuart Tompson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1127. doi:
Characterization of unequivocal haplotypes that encode the 20q13 modifier for variable ages-at-onset of primary open-angle glaucoma Open Access
Vincent Raymond; Pascal Belleau; Stéphane Dubois; Sylvie Desjardins; Rose Arseneault; Patrick Laplante; Eric Shink; Jean-Louis Anctil; Gilles Côté; Marcel Amyot; Michael A. Walter
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1128. doi:
Cross-Ancestry Glaucoma Genetic Risk Score in Hispanic Veterans in the Million Veteran Program Open Access
Andrea R Waksmunski; Tyler Kinzy; Lauren A Cruz; Cari L Nealon; Christopher W Halladay; Scott A Anthony; Paul B Greenberg; Jack M Sullivan; Wen-Chih Wu; Sudha K Iyengar; Dana C Crawford; Neal Peachey; Jessica Cooke Bailey
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1129. doi:
A zebrafish model system for studying the ANGPT/TIE2 pathway and glaucoma Open Access
Shi Song Rong; Anna Larson; Janey L Wiggs
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1130. doi:
Multi-Allelic Interactions of Glaucoma and Anterior Segment Dysgenesis-Associated Genes in the Pathogenesis of Primary Congenital Glaucoma Open Access
Goutham Pyatla; Samir Bera; Alice Anthony; Ashish Mishra; Laura France Moreno-Leon; Anil Kumar Mandal; Sirisha Senthil; Inderjeet Kaur; Rohit C Khanna; Hemant Khanna; Subhabrata Chakrabarti
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1131. doi:
Integrating gene regulation and single cell expression with genetic associations identifies genes and cell types contributing to primary open angle glaucoma risk and intraocular pressure Open Access
Ayellet Vered Segre; Andrew R Hamel; Jiali Wang; John Rouhana; Tavé van Zyl; Wenjun Yan; Alexi mcadams; Aboozar Monavarfeshani; Qingnan Liang; Rui Chen; Joshua R. Sanes; Janey L Wiggs
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1132. doi:
Genetic correlations between smoking- and glaucoma-related traits Open Access
Jessica H. Tran; Kelsey V. Stuart; Clara Cousins; Pirro G Hysi; Anthony P Khawaja; Ron Do; Shantanu Bafna; Jae Kang; Jiali Wang; Stuart MacGregor; Janey L Wiggs; Louis R Pasquale
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1133. doi:
Targeting NMNAT2 for neuroprotection in glaucoma Open Access
Pete A Williams; James R Tribble; Melissa Jöe; Andrea Brancale; Carmine Varricchio; Michael Coleman; Jonathan Gilley; Andrea Loreto; Craig Wheelock; Gauti Johannesson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1134. doi:
NMNAT2 and NAD+ are Downregulated in Glaucomatous RGCs and Overexpression of NMNAT2 Rescues Glaucomatous Neurodegeneration Open Access
Dong Liu; Fang Fang; Pei Zhuang; Xue Feng; Pingting Liu; Haoliang Huang; Liang Li; Wei Chen; Liang Liu; Yang Sun; Haowen Jiang; Jiangbin Ye; Yang Hu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1135. doi:
Neuroprotection of SARM1 Inhibition in Traumatic and Glaucomatous but not in EAE Optic Neuropathies Open Access
Pingting Liu; Haoliang Huang; Wei Chen; Fang Fang; Liang Li; Xue Feng; Liang Liu; Dong Liu; Roopa Dalal; Yang Sun; Karen Ling; Frank Rigo; Yang Hu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1136. doi:
Insulin promotes RGC dendrite regeneration through ribosomal protein S6 kinase activation leading to restoration of neuronal function in glaucoma Open Access
Sana El Hajji; Nicolas A Belforte; Yukihiro Shiga; Florence Dotigny; Adriana Di Polo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1137. doi:
Intraocular sustained release of EPO-R76E mitigates glaucoma pathogenesis by activating the NRF2/ARE pathway in a mouse model of glaucoma Open Access
Tonia S Rex; Sarah Naguib; Jon Backstrom; Carlisle DeJulius; Elisabeth Artis; Craig Duvall
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1138. doi:
Electric Fields Direct Full-Length Optic Nerve Regeneration and Partial Restoration of Visual Function Open Access
Micalla Peng; Phillip Lam; Manjunath Machnoor; Javad Paknahad; Ege Iseri; Xiecheng Shao; Mahnaz Shahidi; Biju Thomas; Gianluca Lazzi; Kimberly Gokoffski
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1139. doi:
Improving integration of transplanted human stem cell derived retinal ganglion cells Open Access
Erika Antuanette Aguzzi; Kevin Yang Zhang; Arumugam Nagalingam; Xiaoli Chang; Donald J Zack; Thomas Vincent Johnson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1140. doi:
Extensive autophagy and unique nuclear excisosome formation from mitochondria characterize organelle degradation in lenses from Galago (bush baby) monkeys Open Access
M Joseph Costello; Kurt O Gilliland; Kevin Schey
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1141. doi:
Endoplasmic reticulum stress enhances lens fibrosis through PERK-mediated autophagy Open Access
Xiaoran Wang; Shan Huang; Yizhi Liu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1142. doi:
Mitotic Activation of Quiescent Lens Epithelial Cells Repairs UVB-Induced Capsular Cataracts Open Access
Zongbo WEI; Caili Hao; Xingjun Fan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1143. doi:
TGFβ overcomes FGF-induced transinhibition of EGFR in lens cells to facilitate fibrotic posterior capsule opacification Open Access
Linda Musil
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1144. doi:
Differential gene expression by human lens epithelial cells in post vitrectomy cataract vs. steroid induced cataract revealed by RNA sequencing Open Access
Michael Dong; Jaynish Shah; Lyndell L Lim; Tiffany Khong; Andrew Spencer; Anthony John Hall
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1145. doi:
Lipid peroxidation induces ferroptosis in the lens epithelium Open Access
Xingjun Fan; Zongbo Wei; Caili Hao; Jingru Huangfu; Ramkumar Srinivasagan; Xiang Zhang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1146. doi:
Metformin-mediated suppression of EMT in lens epithelial cells Open Access
J. Mark Petrash; Biehuoy Shieh; Michelle Pedler
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1147. doi:
Risk of Diabetic Retinopathy (DR) Progression in Patients during 1 year of Semaglutide use Open Access
Blake Cooper; Kellie Howe; Amelia Cooper; Matthew de la Paz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1148. doi:
The influence of ultra-wide field fluorescein angiography on the diagnosis and management of diabetic retinopathy Open Access
Tala Al-Khaled; Nicole K Scripsema; Rawan Allozi Rupnow; Aziz A Khanifar; Thanos Papakostas; Christina Y. Weng; Ronald C Gentile; J. Peter Campbell; Jessica Lee; Felix Y. Chau; William F Mieler; Meenakashi Gupta; Amani A Fawzi; Judy E Kim; Jennifer I Lim; Robison Vernon Paul Chan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1149. doi:
Role of cytoskeletal dynamics in neutrophil activation and cytotoxicity toward retinal endothelial cells in early diabetic retinopathy Open Access
Mahesh Agarwal; Sathishkumar Chandrakumar; Irene Santiago Tierno; Kaustabh Ghosh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1150. doi:
Three Year Outcomes from the PALADIN Phase IV Study: Predictive Value of Prior Steroid Challenge and Intraocular Pressure Outcomes Open Access
Christopher Fuller
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1151. doi:
Suprachoroidal Delivery of RGX-314 for Diabetic Retinopathy: The Phase II ALTITUDE™ Study Open Access
Dilsher Singh Dhoot
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1152. doi:
Engagement of Patients with Diabetic Retinopathy by Telehealth Extenders Improves Follow Up Open Access
Rachel Munzar; Claudia Lasalle; Shiyoung Roh; David J Ramsey
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1153. doi:
Prediction of proliferative diabetic retinopathy (PDR) from nonproliferative diabetic retinopathy (NPDR) using real-world (RW) electronic health record (EHR) data Open Access
Amy Shrader Babiuch; Qi Yang; Dimitrios Damopoulos; Shemra Rizzo; Carolina C S Valentim; Anna K Wu; Fethallah Benmansour; Jennifer Luu; Aneesha Kalur; Resya Sastry; Amogh Iyer; Justin Muste; Galin Spicer; Daniela Ferrara; Rishi P Singh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1154. doi:
Grayscale Retinal Vessel Maps Are Associated with Self-Reported Race: Implications for Artificial Intelligence Models Open Access
Aaron S Coyner; Praveer Singh; James Brown; Susan Ostmo; Robison Vernon Paul Chan; Michael F Chiang; Jayashree Kalpathy-Cramer; J. Peter Campbell
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1155. doi:
Contrastive learning improves representation and transferability of diabetic retinopathy classification models Open Access
Minhaj Nur Alam; Theodore Leng; Joelle Hallak; Daniel Rubin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1156. doi:
Predictors for Non-Diagnostic Images in Real World Deployment of Artificial Intelligence Assisted Diabetic Retinopathy Screening Open Access
Benjamin L Shou; Kesavan Venkatesh; Chang Chen; Ronel Ghidey; Tim Lee; Jiangxia Wang; Alvin Liu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1157. doi:
A Comparison of OCT Angiography Non-Perfusion Area Measurements Made With a Rules-Based Approach and Artificial Intelligence Open Access
Tristan Hormel; Jie Wang; Yukun Guo; Thomas S Hwang; David Huang; Yali Jia
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1158. doi:
Accuracy of Integrated Artificial Intelligence (AI) Grading at the Point of Care (POC) Using Handheld Retinal Imaging in a Community-Based Diabetic Retinopathy (DR) Screening Program (DRS... Open Access
Recivall Salongcay; Lizzie Anne Aquino; Claude Michael Salva; Glenn Paulo Alog; Kaye Locaylocay; Aileen Viguilla Saunar; Cris Martin P. Jacoba; Jennifer K Sun; Lloyd P Aiello; Tunde Peto; Paolo S Silva
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1159. doi:
Five-year Incidence of Arterial Hypertension Predicted by Retinal Vessel Analysis: The Tongren Cohort Study Open Access
Cancan Xue; Cai Li; Dong Ning Chen; Chun Zhang; Ji Cong Zhang; Jost Jonas; Ya Xing Wang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1160. doi:
Eye2Gene: prediction of causal inherited retinal disease gene from multimodal imaging using AI Open Access
NIKOLAS PONTIKOS; William Woof; Peter Krawitz; Gavin Arno; Kristina Hess; Malena Daich Varela; Bart Liefers; Thales Guimaraes; Mital Shah; Savita Madhusudhan; Susan M. Downes; Konstantinos Balaskas; Omar Abdul Rahman Mahroo; Frank G Holz; Michel Michaelides; Andrew R Webster
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1161. doi:
Light-sheet imaging of large-scale neural population activity in the retina. Open Access
Suva Roy; Depeng Wang; Marija Rudzite; Miranda Scalabrino; Yiyang Gong; Alexander Sher; Greg Field
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1162. doi:
Unusual properties of novel ganglion cell and amacrine cell types in macaque and human retina Open Access
Alexandra Kling; Eric Wu; Sam Cooler; Colleen Rhoades; Nora Brackbill; Alan Litke; Alexander Sher; EJ Chichilnisky
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1163. doi:
Dual patch-clamp recording of synaptic transmission between morphologically and physiologically characterized cone bipolar cell types and a diffused ganglion cell in wholemount mouse reti... Open Access
Yao Xue; Seunghoon Lee; Jimmy Zhou
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1164. doi:
Non-classical center-surround antagonism in the retina controls spatial and temporal filtering in scotopic light Open Access
Norianne Ingram; Fred Rieke
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1165. doi:
Campana cells relay both rod- and cone-mediated visual signals to multiple RGC types Open Access
Ning Tian; Brent K Young; Ping Wang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1166. doi:
Neuronal firing between retinal ganglion cells and coupled amacrine cells in the mouse retina Open Access
Qin Wang; Chung Him So; Feng Pan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1167. doi:
Complex non-tumor retinal ganglion cell-glial interrelationships in neurofibromatosis-optic pathway glioma (NF1-OPG) mice Open Access
Steven F Stasheff; Francisco Nadal-Nicolas; Wei Li; Yuan Zhu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1168. doi:
BAP1 immunohistochemistry in post-brachytherapy uveal melanoma Open Access
Maya Eiger-Moscovich; Carol L. Shields; Ralph C. Eagle Jr.; Tatyana Milman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1456. doi:
The clinical applicabillity of IHC staining for BAP1 for prognostication of uveal melanoma Open Access
Jens F Kiilgaard; Carsten Faber; Mette Marie Bagger; Steffen Heegaard; David Scheie
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1457. doi:
Potential of aqueous humor as a liquid biopsy for uveal melanoma Open Access
Deborah Im; Chen-Ching Peng; Liya Xu; Mary Elizabeth Kim; Dejerianne Ostrow; Venkata Yellapantula; Moiz Bootwalla; Jaclyn A Biegel; Xiaowu Gai; Peter Kuhn; James Hicks; Jesse L Berry
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1458. doi:
In vivo intraocular biomarkers in uveal melanoma: an aqueous humor proteomic study. Open Access
Giulia Midena; Raffaele Parrozzani; Marisa Bruno; Graziana Esposito; Alessandra Micera; Edoardo Midena
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1459. doi:
Targeting Bromodomain of Brg-1 in Uveal Melanoma Cells with Small Molecule PFI-3: A Possible Novel Therapy Open Access
Matthew W Wilson; Emily Louie; Chuanhe Yang; Yinan Wang; Lawrence M Pfeffer
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1460. doi:
Imipridones target mitochondrial oxidative phosphorylation effectors in uveal melanoma to control growth Open Access
Chandrani Chattopadhyay; Fatima S. Khan; Rajat Bhattacharya; Jason Roszik; Elizabeth A. Grimm
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1461. doi:
The role of early growth response-1 in uveal melanoma viability and treatment resistance to MEK inhibition Open Access
Lauren A Dalvin; Cynthia Andrews-Pfannkoch; Jose S Pulido; David R Miley; Samantha Adams
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1462. doi:
Transient Receptor Potential Nociceptors are Required for Contact Lens-Associated Corneal Parainflammation Open Access
ANANYA DATTA; Justin Lee; Hart Horneman; David J Evans; Suzanne M J Fleiszig
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1463. doi:
Myopia control effect of small back optic zone diameter orthokeratology lenses over two years Open Access
Biyue Guo; Sin Wan Cheung; Randy Kojima; Pauline Cho
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1464. doi:
Antimicrobial efficacy of novel Ultraviolet- C device against microorganisms related to Contact lens keratitis. Open Access
SRIKANTH DUMPATI; Sunil Shah; Shehzad Naroo; Debarun Dutta
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1466. doi:
Protection Against Localized Corneal Hyperosmolarity Spikes with Soft-Contact-Lens Wear Open Access
Young Hyun Kim; Meng C Lin; CHENG-CHUN PENG; Clayton J Radke
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1467. doi:
Developing a novel in vitro eye model using 3D bioprinting for drug delivery studies Open Access
Chau-Minh Phan; Wulff David; Piyush Garg; Lyndon William Jones
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1468. doi:
Intraocular Pressures Changes at the Central Cornea and Sclera during 5 hours of Scleral Lens Wear Open Access
Vivien Tse; Taras Litvin; Lisa Chung; Yixiu Zhou; Ying Han; Meng C Lin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1469. doi:
Synthetic Matrices with Customizable Cell-Matrix Interfaces Enhance Retinal Organoid Culture Open Access
Daniel Balikov; Brian Basinski; Ariella Shikanov; Rajesh Rao
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1470. doi:
Achromatopsia Retinal Organoid Transcriptomes Reveal Increased Gliosis and Dysregulation of Unfolded Protein Response Open Access
Monica Diaz-Aguilar; Jihee Choi; Hyejung Min; Eun-Jin Lee; Julia M.D. Grandjean; Heike Kroeger; R. Luke Wiseman; Jonathan Lin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1471. doi:
CRISPR -Cas9-mediated gene correction in Induced Pluripotent Stem Cells derived from Oculocutaneous Albinism Type 2 patients rescues pigmentation defect in Retinal Pigment Epithelium Open Access
Arnold Leigh; Tyler Pfister; Aman George; Ruchi Sharma; Mones Abu-Asab; Kapil Bharti; Brian Patrick Brooks
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1472. doi:
Complement dysregulation in an iPSC-RPE model with CFH/FHL-1 haploinsufficiency. Open Access
Rayne Lim; Sharlene Shirali; Jessica Rowlan; Abbi Engel; Marcos Nazario; Jianhai Du; Maureen Neitz; Jay Neitz; Jennifer R Chao
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1473. doi:
Generation of choroid and RPE cells from iPSC with CFH knockout for modeling of AMD Open Access
Tea Soon Park; Russell Quinn; Rishabh Hirday; Amir Ali; Eric Nguyen; Devika Bose; Ruchi Sharma; Kapil Bharti
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1474. doi:
Autophagy Dysfunction Represses mTORC1 Signaling Resulting in Neurodegeneration of Retinal Ganglion Cells in Glaucoma Open Access
Kang-Chieh Huang; Cátia Gomes; Yukihiro Shiga; Kirstin VanderWall; Sailee Sham Lavekar; Clarisse Fligor; Jade Harkin; Adriana Di Polo; Jason S Meyer
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1475. doi:
Modeling autosomal dominant retinitis pigmentosa associated with copy number variants in rhodopsin and rescue using Photoregulin3 in patient-specific retinal organoids Open Access
Sangeetha Kandoi; Cassandra Martinez; Kevin A Xu Chen; Brian Mansfield; Jacque L Duncan; Deepak A Lamba
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1476. doi:
Revealing spectral cone types from structural differences as obtained by AO-OCT imaging in human subjects Open Access
Qiuzhi Ji; Davin Miller; Marcel Bernucci; Yan Liu; James Crowell; Donald Thomas Miller
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1477. doi:
Optogenetic stimulation and calcium imaging of single ganglion cells in the living macaque fovea Open Access
Peter Murphy; Juliette E McGregor; Zhengyang Xu; William Merigan; David R Williams
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1478. doi:
Combining adaptive optics with erythrocyte mediated angiography reveals preferential sites of erythrocyte stasis within the choriocapillaris Open Access
Joanne Li; Andrew J. Bower; Jessica Pottenburgh; Victoria Chen; Laryssa Huryn; Osamah Saeedi; Johnny Tam
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1479. doi:
Pilot investigation of multimodal and multiscale retinal imaging technology developed by a trans-European multidisciplinary consortium Open Access
Kiyoko Gocho; Nicolas Lefaudeux; Claudia Valdes; Jordi Andilla; Muhammad Faizan Shirazi; Florian Schwarzhans; Konstantinos Ntatsis; Luisa Sanchez Brea; Danilo Andrade De Jesus; Marie Elise Wistrup Torm; Christina Eckmann-Hansen; Abdullah Amini; Kate Grieve; Pablo Loza-Alvarez; Michael Pircher; Michel Paques
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1480. doi:
Evaluation of the double-pass wavefront in model and human eyes Open Access
Vyas Akondi; Xiaojing Huang; Alfredo Dubra
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1481. doi:
Phase imaging in the inner retina Open Access
Mircea Mujat; Ankit Patel; John Grimble; Nicusor Iftimia
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1482. doi:
In vivo recumbent photoreceptor imaging using the first handheld adaptive optics optical coherence tomography probe Open Access
Kristen Hagan; Jongwan Park; Theodore DuBose; Somayyeh Soltanian-Zadeh; Gar Waterman; Al-Hafeez Dhalla; Anthony N Kuo; Ryan McNabb; Joseph Izatt; Sina Farsiu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1483. doi:
The Endothelin Receptor Antagonist Macitentan Acts through both Vascular and Cellular Mechanisms to Promote Neuroprotection of Retinal Ganglion Cells in Rodents. Open Access
Raghu R Krishnamoorthy; Bindu Kodati; Sai H Chavala; Wei Zhang; Dorota Luiza Stankowska
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1484. doi:
2-Fluoro-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)nicotinamide (HIFN) protects against vision loss from closed-globe ocular trauma by activating tropomyosin-related kinase B (TrkB) Open Access
Shweta Modgil; Christopher L Walker; Frank E McDonald; P. Michael Iuvone
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1485. doi:
Baicalein Alleviates Microglia-mediated Neuroinflammation and Neurodegeneration in Mouse Retina Open Access
Li PAN; Kin-Sang Cho; Dongfeng Chen; Chi-wai Do
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1486. doi:
Constitutively active Ras promotes protection and axon regeneration in retinal ganglion cells after optic nerve injury Open Access
Naoki Kiyota; Kazuhiko Namekata; Xiaoli Guo; Atsuko Kimura; Toru Nakazawa; Takayuki Harada
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1487. doi:
Role of DNA Methylation in RGC Death during Glaucoma Progression Open Access
Shahid Husain; Sudha Singh; Wendy Guzman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1488. doi:
Biomarkers for Alzheimer’s Disease & Chronic Traumatic Encephalopathy in Postmortem Vitreous Humor Correlate with Pathological Diagnosis and Cortical Brain Tissue Open Access
Viha Vig; Fatima Tuz-Zahra; Yorghos Tripodis; Jia Xu; Weiming Xia; Goayuan Meng; Thor D. Stein; Manju L Subramanian
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1489. doi:
Ethambutol-induced optic atrophy: a mitochondrial fission neuropathy mediated by NO? Open Access
Lin Cheng; Hanna Shevalye; Gregory Schmidt; Jessica Skeie; Mark A Greiner; Markus H Kuehn
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1490. doi:
Adenosine receptor 2A-mediated HIF signaling enhances endothelial-to-mesenchymal transition (EndMT) and promotes subretinal fibrosis Open Access
Qiuhua Yang; Qian Ma; Xiaoxiao Mao; Akrit Sodhi; Ruth B Caldwell; Yuqing Huo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1491. doi:
Efficacy of iRGD-Targeted Fusogenic Nanoparticle Delivering VEGF-siRNA to a Rabbit Model of Retinal Angiogenesis Open Access
William R Freeman; Joel F Grondek; Kristyn Huffman; Melina Cavichini Cordeiro; Alexandra Warter; Fritz Gerald P Kalaw; Lingyun Cheng; Ella Jiyoon Lee; Ruhan Fan; Michael J Sailor
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1492. doi:
Rhesus macaques with soft drusen share susceptibility genes with age-related macular degeneration in humans. Open Access
Glenn Yiu; Jun Wang; Yumei Li; Kevin Choy; Sina Farsiu; Leon Huynh; Karolina Paulina Roszak; Ala Moshiri; Sara M Thomasy; Rui Chen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1493. doi:
Metabo-endotypes of Age-related Macular Degeneration Open Access
Kevin Milton Mendez; Ines Lains; rachel kelly; John B Miller; Demetrios G. Vavvas; Ivana K Kim; Joan W Miller; Liming Liang; Jessica A Lasky-Su; Deeba Husain
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1494. doi:
Genetic variants in ANO2 may be predictive for treatment response to anti-VEGF in neovascular age-related macular degeneration Open Access
Robyn H Guymer; Rufino Silva; Mercedeh Ghadessi; Sergio Leal; Isabella Gashaw; Amy Damask; Charles Paulding; Kay D. Rittenhouse
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1495. doi:
Assessing vitreous cortex hyalocyte morphology and dynamics in the living human eye Open Access
Richard B Rosen; Oscar Otero-Marquez; Justin V Migacz; Sofia Ahsanuddin; Kara Rickford; Brian Murillo; Rebecca Zhou; Lily Spellman; Rishard Weitz; Alfredo Dubra; Toco Yuen Ping Chui
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1496. doi:
Suprachoroidal Delivery of RGX-314 Gene Therapy for Neovascular AMD: The Phase II AAVIATE™ Study Open Access
Arshad M. Khanani
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1497. doi:
Development and validation of prognostic models to increase power of clinical trials for geographic atrophy (GA) Open Access
Verena Steffen; Neha Anegondi; Qi Yang; Michel Friesenhahn; Daniela Ferrara; Simon S Gao; Christina Rabe
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1498. doi:
Results of a Delphi consensus study of geographic atrophy (GA) diagnosis and current management Open Access
Rishi P Singh; Winfried M K Amoaku; Francesco Bandello; Fred Kuanfu Chen; Frank G Holz; Preeti Joshi; Laurent Kodjikian; José María Ruiz-Moreno; Charles Clifton Wykoff
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1499. doi:
Efficacy of intravitreal pegcetacoplan in patients with geographic atrophy (GA): 12-month results from the phase 3 OAKS and DERBY studies. Open Access
Roger Goldberg; Jeffrey S Heier; Charles Clifton Wykoff; Giovanni Staurenghi; Rishi P Singh; Nathan Steinle; David S Boyer; Jordi Mones; Frank G Holz; Caleb Bliss; Federico Grossi; Ravi Metlapally; Ramiro Ribeiro
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1500. doi:
Impact of baseline imbalances on the efficacy of pegcetacoplan for the treatment of geographic atrophy (GA): A post hoc analysis of OAKS, DERBY, and FILLY Open Access
Sunir Garg; Charles Clifton Wykoff; Nathan Steinle; Giovanni Staurenghi; Debra Morris; Allen Chiang; Caleb Bliss; Daniel Jones; Ramiro Ribeiro; Allen C Ho; Jeffrey S Heier
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1501. doi:
Patient characteristics from a post hoc analysis of nascent geographic atrophy progression following treatment with avacincaptad pegol from the GATHER1 study Open Access
Carl J Danzig
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1502. doi:
Learning-based modelling for longitudinal prediction of geographic atrophy growth rate Open Access
Tharindu de silva; Tiarnan D L Keenan; Emily Y Chew; Catherine Cukras
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1503. doi:
Preliminary Results from a First-in-human Phase I/II Gene Therapy Study (FOCUS) of Subretinally Delivered GT005, an Investigational AAV2 Vector, in Patients with Geographic Atrophy Second... Open Access
Jared Nielsen; Robert E MacLaren; Jeffrey S Heier; David Steel; Tsveta Ivanova; Sobha Sivaprasad; Paulo Stanga; Clare Bailey; Peter Charbel Issa; Luisa Mendonca; James Francis; Darin Curtiss; Jane Hughes; Nadia K Waheed
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1504. doi:
Quality of life in children and adults with childhood glaucoma: An interview study Open Access
Lachlan Knight; Bronwyn Ridge; Sandra E Staffieri; Jamie E Craig; Mallika Prem Senthil; Emmanuelle Souzeau
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1823. doi:
Glaucoma reduces vision-related quality of life: results from the population-based Gutenberg Health Study Open Access
Stephanie D Grabitz; Annika Junglas; Esther M Hoffmann; Julia Verena Stingl; Stefan Nickels; Philipp Wild; Karl Lackner; Thomas Münzel; Manfred E Beutel; Irene Schmidtmann; Norbert Pfeiffer; Alexander Karl-Georg Schuster
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1824. doi:
Differences in Vision-Specific Quality of Life with Visual Acuity by Race, Ethnicity in the Multiethnic Ophthalmology Cohorts of California Study (MOCCaS) Open Access
Roberta McKean-Cowdin; Dominic Joseph Grisafe; Mina Torres; Bruce Burkemper; Kaili Ding; Xuejuan Jiang; Benjamin Xu; Rohit Varma
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1825. doi:
Prevalence of falls and fall-related outcomes in older adults with diagnoses of ocular disease Open Access
Brittany Tsou; Dana Huh; Pradeep Y Ramulu; Fasika Woreta
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1826. doi:
PrevenTing Falls in a high-risk, low vision population through specialist ORientation and Mobility services: the PlaTFORM randomised trial Open Access
Lisa Keay; Lisa Dillon; Kelly Prentice; Kirsten Jakobsen; Kris Rogers; Jodi Martin; Rebecca Ivers; Anne Tiedemann; Cathie Sherrington; Pradeep Y Ramulu; Peter J McCluskey; Stephen Jan; Ashleigh Chandra; Sheela Kumaran; Xiaoqiu (Julia) Liu; Lindy Clemson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1827. doi:
The ageing visual function system and functional health in multi-ethnic older adults: The PIONEER study Open Access
Preeti Gupta; Alfred TL Gan; Ryan EK Man; Eva K Fenwick; Ecosse Luc Lamoureux
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1828. doi:
Relationship between Severity and Laterality of Age-Related Sensory Decline and Frailty In Multi-ethnic Elderly Asians Open Access
Ecosse Luc Lamoureux; Ryan EK Man; Alfred TL Gan; Eva K Fenwick; Preeti Gupta
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1829. doi:
Phase Decorrelation OCT for Monitoring Accelerated Crosslinking: Depth Resolution and Improved Scan Area Open Access
Brecken Blackburn; Matthew McPheeters; Michael W Jenkins; William J Dupps; Andrew M. Rollins
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1830. doi:
Correlation of clinical fibrillar layer detection with corneal thickness in advanced Fuchs endothelial corneal dystrophy eyes. Open Access
Mario Matthaei; Orlando Özer; Mert Mestanoglu; Antonia Howaldt; Thomas Clahsen; Sebastian Siebelmann; Niklas Reinking; Claus Cursiefen; Björn Bachmann
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1831. doi:
Investigating the Potential Effects of Peroxisome Proliferator-Activated Receptor (PPAR)-α Agonists on Corneal Nerve Regeneration in Patients with Type II Diabetes Mellitus Open Access
Calesta Hui Yi Teo; Hong Chang Tan; Molly Tzu-Yu Lin; Isabelle Xin Yu Lee; Jodhbir S Mehta; Yu-Chi Liu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1832. doi:
Effect of Trigeminal Nerve Stimulation on Chronic Ocular Pain and Corneal Nerve Density in Sub-basal Plexus Open Access
Simran Mangwani-Mordani; Arturo Ramírez-Miranda; Enrique O Graue-Hernandez; Alejandro Navas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1833. doi:
OK-101, A Novel Chemerin Receptor Agonist, Ameliorates Neuropathic Corneal Pain in a Mouse Model of Ciliary Nerve Ligation Open Access
Deshea L Harris; Fangfang Qiu; Ayesha Sultan; Raj Patil; Gary S. Jacob; Pedram Hamrah
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1834. doi:
Identifying Small-fiber Neuropathy of the Corneal Sub-Basal Nerve Plexus in Sjögren Syndrome Using In-Vivo Confocal Microscopy Open Access
Jeremy Nortey; Elisabeth Gebreegaziabher; Jeremy D Keenan; Tom Lietman; John Alexander Gonzales
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1835. doi:
Deep Learning-based Segmentation of Nerves and Pathological Structures in Corneal Confocal Microscopy Images of the Subbasal Nerve Plexus Open Access
Zane Zemborain; Matias Soifer; Nadim Azar; Hazem M Mousa; Victor L Perez; Sina Farsiu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1836. doi:
Clinical Characteristics and Response to Eye Muscle Surgery in 15 Children Patients With Dyschromatopsia and Infantile Nystagmus Syndrome (INS) Open Access
Richard W Hertle; Ian Boydstun; Ana Juric De Paula
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1837. doi:
Truncating PAX6 mutations result in severe arrested retinal development with loss of cone photoreceptor specialisation: A multi-centre study Open Access
Mervyn George Thomas; Helen Kuht; Jinu Han; Gail Maconachie; Rebecca McLean; Zhanhan Tu; Viral Sheth; Martin Tobin; Brian Patrick Brooks; Elizabeth Engle; Irene Gottlob
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1838. doi:
The Genotypic and Phenotypic Spectrum of Foveal Hypoplasia: A Multi-centre Study on behalf of the Foveal Development Investigators Group (FDIG) Open Access
Helen Kuht; Jinu Han; Line Kessel; Mies M. van Genderen; Richard W Hertle; Karen Gronskov; Vasily Smirnov; Fred Kuanfu Chen; Rachael C Heath Jeffery; Brian Patrick Brooks; Sasha Strul; Jin Jing; Martin Tobin; Irene Gottlob; Mervyn George Thomas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1839. doi:
Phenotypic Characteristics as a Diagnostic Tool for Albinism: Sensitivity and Specificity Analysis Open Access
Abdullah Aamir; Helen Kuht; Jinu Han; Mies M. van Genderen; Gail Maconachie; Rebecca McLean; Zhanhan Tu; Viral Sheth; Richard W Hertle; Line Kessel; Brian Brooks; Frank A Proudlock; Irene Gottlob; Mervyn George Thomas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1840. doi:
Investigation of extraocular muscle development in a mouse model of infantile nystagmus syndrome Open Access
Mary Whitman; Sampath Kumar Vemula; Seoyoung Kim
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1841. doi:
Masquerading Superior Oblique Palsy Mimics All Features of Congenital and Acquired Superior Oblique (SO) Muscle Weakness Open Access
Joseph L Demer
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1842. doi:
Magnetic resonance imaging analysis of age-related distance esotropia in geriatric Indian subjects Open Access
Zia Chaudhuri; Pratibha Kataria; Umesh Chandra Garga; Yashvant Singh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1843. doi:
Deep unsupervised discovery of OCT phenotypes enables genome-wide analyses Open Access
Nazlee Zebardast; Mojtaba Fazli; Sayuri Sekimitsu; Saber Kazeminasab Hashemabad; Tobias Elze; Ayellet V. Segrè; Mengyu Wang; Janey L Wiggs
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1844. doi:
Lower Diastolic Blood Pressure: A Risk Factor for Faster GCC Rates of Progression in Patients with Moderate to Advanced Glaucoma Open Access
Kouros Nouri-Mahdavi; Vahid Mohammadzadeh; Massood Mohammadi; Erica Su; Lynn Shi; Anne L. Coleman; Simon K. Law; Joseph Caprioli; Robert E Weiss
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1845. doi:
Cerebrospinal fluid dynamics and its coupling with global brain activity are altered in early glaucoma patients Open Access
Ji Won Bang; Eva Yarsky; Gadi Wollstein; Joel S Schuman; Kevin C. Chan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1846. doi:
Intraocular pressure, ocular perfusion pressure, retinal perfusion and electrophysiology in brain-dead organ donors Open Access
Mary Anne Garner; Massimo A. Fazio; Mark Clark; Udayakumar Karuppanan; Meredith Hubbard; Seth Hubbard; Alecia K Gross; Christopher A Girkin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1847. doi:
Schlemm canal-targeted Tie2 knockdown (SC-Tie2 KD) as mouse model of adult-onset human glaucoma Open Access
Alejandra Bosco; Cesar O Romero; Joon Schwakopf; Oleg Yarishkin; J Cameron Millar; Michael Steele; David Krizaj; Monica L Vetter
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1848. doi:
In Vivo Evaluation of Naïve and Diseased RGC Activities at Single-Cell Level Open Access
Liang Li; Fang Fang; Xue Feng; Shaobo Zhang; David Andrew Miller; Pei Zhuang; Haoliang Huang; Pingting Liu; Junting Liu; Nripun Sredar; Liang Liu; Yang Sun; Xin Duan; Jeffrey L Goldberg; Hao Zhang; Yang Hu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1849. doi:
Light-evoked RGC calcium dynamics are altered in glaucoma: live imaging evidence of abnormal calcium clearance Open Access
Yukihiro Shiga; Aline Giselle Rangel Olguin; Luis Alarcon-Martinez; Nicolas A Belforte; Heberto Quintero; Deborah Villafranca-Baughman; Florence Dotigny; Arjun Krishnaswamy; Adriana Di Polo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1850. doi:
Active Transport of Cationic Liposomes Across the Retina Open Access
Anne Zebitz Eriksen; Fredrik Melander; Paul Joseph Kempen; Andreas Kjaer; Thomas Lars Andresen; Andrew James Urquhart
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1851. doi:
IDENTIFYING BIO-INTELLIGENCE AT BLOOD-AQUEOUS BARRIER IN PREDICTING AQUEOUS HUMOR PENETRATION USING QSPR APPROACH Open Access
Ujjalkumar Subhash Das; Nabanita Halder; Jeevan S Titiyal; Baskar S. Singh; B Jayaram; Vishnubhatla Sreenivas; Thirumurthy Velpandian
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1852. doi:
Photodisruption of the ILM to enhance retinal drug delivery after intravitreal injection Open Access
Karen Peynshaert; Kaat De Clerck; Helena Vanluchene; Geraldine Accou; Félix Sauvage; An-Katrien Minnaert; Kevin Braeckmans; Stefaan De Smedt; Katrien Remaut
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1853. doi:
Contact lenses that deliver statins Open Access
Ana Filipa Pereira-da-Mota; María Vivero-López; María Serramito; Fernando Huete-Toral; Gonzalo Carracedo; Angel Concheiro; Carmen Alvarez-Lorenzo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1854. doi:
A novel, minimally invasive implant for intraocular drug delivery Open Access
Rohan Chawla; Dinesh Kalyanasundaram; Laxmi Moksha; Jayanta Bhattacharyya; Anjali Phour; Thirumurthy Velpandian; Seema Kashyap
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1855. doi:
Effective intracameral injection in the mouse model Open Access
Jennyfer Zapata; Alexandre Abid; Mohamed Djallali; Marilyse Piché; Michel Meunier; Christos Boutopoulos; Isabelle Brunette
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1856. doi:
Biodegradable silicon nanoneedles for sustained treatment of angiogenesis Open Access
Yannis Mantas Paulus; Woohyun Park; Van Phuc Nguyen; Chi Hwan Lee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1857. doi:
Large-Area RPE Removal by Microsecond Laser followed by hiPS-RPE transplantation Open Access
Boris V. Stanzel; Christian Burri; Sami Al-Nawaiseh; Philip Wakili; Sylvia Jane Gasparini; Gerardo Farese; Christina Kroetz; Boris Greber; Christoph Meier; Martin Frenz; Peter Szurman; André Schulz; Marius Ader
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1858. doi:
In Vivo Tracking of Transplanted Progenitor Cells after Photocoagulation Using Multimodal Photoacoustic Microscopy, OCT, and Fluorescence Imaging Open Access
Phuc Nguyen; Wen Fan; Tianye Zhu; Wei Qian; Yanxiu Liu; Binh Liu; Wei Zhang; Jessica Henry; Songtao Yuan; Xueding Wang; Yannis M. Paulus
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1859. doi:
Automated production of patient derived iPSCs for autologous photoreceptor cell replacement. Open Access
Budd A. Tucker; Laura R Bohrer; Nicholas E Stone; Kristin R. Anfinson; Cathryn M. Schaffer; Meagan A Luse; Bradley A. Hittle; Kimerly A. Powell; George F. Muschler; Robert F Mullins; Edwin M Stone
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1860. doi:
Effects OF CRISPR knockout of the Humanin trimeric CNTFR/gp130/WSX-1 receptor in AMD Open Access
Sonali R Nashine; M.Cristina Kenney
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1861. doi:
Safety and Efficacy of a Phase 1/2a Clinical Trial of Transplanted Allogeneic Retinal Pigmented Epithelium (RPE, OpRegen) Cells in Advanced Dry Age-Related Macular Degeneration (AMD) Open Access
Allen C Ho; Eyal Banin; Adiel Barak; David S Boyer; Rita Ehrlich; Tareq Jaouni; H Richard MacDonald; Christopher D Riemann; David Telander; Jordi Mones; Avi Ben Shabat; Gary S Hogge; Benjamin Reubinoff
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1862. doi:
Suprachoroidal Retinal prostheses, longterm stability and safety results. Open Access
Penelope J Allen; Carla J Abbott; Maria Kolic; Elizabeth Baglin; David AX Nayagam; Stephanie Epp; Nicholas Barnes; Chi D Luu; Robert Briggs; Jonathan Yeoh; William Kentler; Samuel Titchener; Christopher E Williams; Matthew Petoe
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1863. doi:
Long-term integration of the retina with 3D implants: structure and function Open Access
Bing-Yi Wang; Mohajeet Balveer Bhuckory; Zhijie Charles Chen; Andrew Shin; Ludwig Galambos; Keith Mathieson; Theodore Kamins; Daniel V Palanker
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1864. doi:
The polycomb repressor complex 2 influences glial reactivity and the formation of Müller glia-derived progenitor cells in the chick retina Open Access
Heithem M El-Hodiri; Warren Campbell; Diego Torres; Evan C Hawthorn; Lisa E Kelly; Leo Volkov; Andy J Fischer
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1865. doi:
Cross-species single-cell transcriptomic analysis reveals factors limiting human Müller glial-derived retinal regeneration Open Access
Rahul Dhodapkar; Diego Martell; Eda Calapkulu; Yu Xing; Le Zhang; Madhvi Menon; Andrew Jin; Alex Dong; Brian Palmer Hafler
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1866. doi:
RPE neural competency is restricted by alterations to a homeobox transcription factor regulatory network Open Access
Jared Austin Tangeman; Raúl Pérez-Estrada; Emily Van Zeeland; Lin Liu; Chun Liang; Katia Del Rio-Tsonis
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1867. doi:
Sphingosine 1 Phosphate Signaling Enhances NF-κB Activation and Suppresses Muller Glia Reprogramming in the Injured Retina Open Access
Olivia Taylor; Andy J Fischer
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1868. doi:
Regulation of Retinal Regeneration by the Extracellular Matrix Protein Nephronectin Open Access
Dmitri Serjanov; James Twist; Meghan Swantkowski; David Hyde
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1869. doi:
Notch inhibition promotes regeneration and immunosuppression supports cone survival in a zebrafish model of inherited retinal dystrophy Open Access
Brian D Perkins; Ping Song; Joseph Fogerty; Patrick Boyd; Sarah Grabinski; Thanh V Hoang; Seth Blackshaw; Jeff S Mumm; David Hyde
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1870. doi:
Inducing regeneration of retinal ganglion-like cells in vivo from Muller glia in the adult mouse using transcription factors. Open Access
Levi Todd; Wesley Jenkins; Marcus Hooper; Connor Finkbeiner; Thomas Reh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1871. doi:
Plasma metabolomics of primary open-angle glaucoma in three prospective US cohorts and the UK Biobank Open Access
Oana Alina Zeleznik; Jae Kang; Jessica A Lasky-Su; Clary B Clish; Bernard Rosner; Tobias Elze; Anthony Khawaja; Janey L Wiggs; Louis R Pasquale
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2263. doi:
Association of alcohol consumption with glaucoma and related traits Open Access
Kelsey Vernon Stuart; Robert Luben; Alasdair Warwick; Kian Madjedi; Praveen Patel; Marleen Lentjes; Paul Foster; Anthony Khawaja
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2264. doi:
Long-Term Alcohol Consumption and Risk of Exfoliation Glaucoma among US Health Professionals Open Access
Jae Kang; Akiko Hanyuda; Bernard Rosner; Janey L Wiggs; Louis R Pasquale
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2265. doi:
Impact of Smoking on Visual Field Progression Open Access
Golnoush Mahmoudinezhad; Takashi Nishida; Robert N Weinreb; Sally Baxter; Medi Eslani; Jeffrey M Liebmann; Massimo A. Fazio; Christopher A Girkin; Linda Zangwill; Sasan Moghimi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2266. doi:
Association of commonly used systemic medications with glaucoma prevalence and intraocular pressure across Europe: the E3 Consortium Open Access
Alexander Karl-Georg Schuster; Joëlle Vergroesen; Kelsey Vernon Stuart; Geir Bertelsen; Fotis Topouzis; Mukharram Bikbov; Catherine Creuzot-Garcher; Cecile Delcourt; Rufino Silva; Nomdo M Jansonius; Franziska G Rauscher; Caroline C W Klaver; Norbert Pfeiffer; Wishal D Ramdas; Anthony P Khawaja
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2267. doi:
Plant-based low carb diet and other risk factors in relation to incident primary open-angle glaucoma characterized by autonomously determined visual field loss patterns Open Access
Akiko Hanyuda; Mengyu Wang; Bernard Rosner; Janey L Wiggs; Tobias Elze; Louis R Pasquale; Jae Kang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2268. doi:
Bidirectional association of glaucoma and chronic kidney disease: a systematic review and meta-analysis of two million participants Open Access
Faye Yu Ci Ng; Harris Jun Jie Muhammad Danial Song; Benjamin Kye Jyn Tan; Chong Boon Teo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2269. doi:
Hedgehog signaling promotes expansion of Meibomian Gland stem cells in vivo Open Access
Xuming Zhu; Mingang Xu; Marina Grachtchouk; Andrzej A Dlugosz; Sarah E Millar
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2270. doi:
Pathophysiological consequences of Soat1/SOAT1 inactivation for the ocular surface and Meibomian gland homeostasis Open Access
Amber Wilkerson; Igor A Butovich
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2271. doi:
Characterization of Mouse Meibomian glands by single cell RNA sequencing. Open Access
James V Jester; Julie Wiedemann; Shelley Lane; Ghaidaa Kashgari; Donald Brown; Bogi Andersen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2272. doi:
Sensing local osmolarity of the tear film on the corneal surface using fluorescent dye-loaded nanoliposomes Open Access
Sudhir H Ranganath; M.Y. Thanuja; Joseph A Bonanno; Sangly P Srinivas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2273. doi:
Novel murine model for autoantibody-induced dry eye disease Open Access
Simon Kaja; Marianna Bacellar-Galdino; Christine Mun; Anita K. Ghosh; Sandeep Jain
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2274. doi:
Effects of Age and Genetic Diversity Background on Ectopic Lymphoid Structures in the Lacrimal Gland Open Access
Cintia S De Paiva; Kaitlin Scholand; Helen P Makarenkova; Zhiyuan Yu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2275. doi:
Reduced RXRα signaling increases dry eye disease inducing γδT17 cells in the conjunctiva Open Access
Stephen C Pflugfelder; Jahan Alam; Ghasem Yazdanpanah; Rinki Ratnapriya; Nicholas Borcherding; Cintia S De Paiva; De-Quan Li; Rodrigo Guimaraes de Souza; Zhiyuan Yu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2276. doi:
Deletion of Zeb1 blocks injury-induced endothelial mesenchymal transition in the mouse corneal endothelium in vivo Open Access
J. Martin Heur; JeongGoo Lee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2277. doi:
RNA-Seq based transcriptome analysis of corneal endothelial cells derived from the patients with Fuchs endothelial corneal dystrophy Open Access
Tatsuya Nakagawa; Naoki Okumura; Yuya Komori; Naoya Hanada; Yuichi Tokuda; Masakazu Nakano; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Noriko Koizumi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2278. doi:
Transcriptomic and metabolomic analyses of Fuchs endothelial corneal dystrophy and bullous keratopathy Open Access
Takefumi Yamaguchi; Yukari Yagi-Yaguchi; Takanori Suzuki; Hirotsugu Kasamatsu; Kazunari Higa; Masahiro Sugimoto; Hisashi Noma; Jun Shimazaki
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2279. doi:
Effects of long-term application of topical ROCK inhibitor on corneal endothelium and Descemet’s membrane of TAZ deficient mice Open Access
Sara M Thomasy; Sangwan Park; Krista Cosert; Michelle Mccorkell; Nayeli Echeverria; Sophie M Le; Christopher J Murphy; Vijaykrishna Raghunathan; Brian C Leonard
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2280. doi:
Berberine rescues corneal endothelial cell loss in Fuchs dystrophy Open Access
Raymond Wong; Neha Deshpande; Varun Kumar; Ula V Jurkunas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2281. doi:
Development of a research pipeline to identify novel treatments for Fuchs Endothelial Corneal Dystrophy Open Access
Matilda F Chan; Szu-Yu Kuo; Finn Wolfreys; Eric Ding; Martin Kampmann; Jason E. Gestwicki; Peipei Pan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2282. doi:
Sex Difference in Congenital Hereditary Endothelial Dystrophy and a Slc4a11-/- mouse model Open Access
Wenlin Zhang; Dominic Williams; Onyinye Onyia; Marco Morselli; Matteo Pellegrini; Arthur Arnold; Anthony J Aldave
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2283. doi:
Monocular visual acuity does not accurately represent function of the amblyopic eye during binocular viewing Open Access
Eileen E Birch; Reed M Jost; Lindsey A Hudgins; Sarah E Morale; Matt Donohoe; Krista R Kelly
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2284. doi:
Fixation Eye Movement Abnormalities, Stereopsis and Inter-ocular suppresion in Amblyopia. Open Access
Fatema Firoz Ghasia; Cody Dulaney; Jordan Murray
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2285. doi:
Dose-response relationship and treatment efficiency for patching vs gaming therapy for amblyopia Open Access
Aveen Kadhum; Emily Tan; Maria Fronius; Maurits V. Joosse; Huibert Jan Simonsz; Sjoukje E Loudon
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2286. doi:
Bilateral Lateral Rectus Muscle Recessions Versus Recess-Resect for Childhood Intermittent Exotropia (IXT): 8-year Outcomes Open Access
Sean Donahue; Danielle L Chandler; Rui Wu; Christine Law; Raymond G Areaux; Fatema Firoz Ghasia; Justin D Marsh; Christina A Esposito; Zhuokai Li; Raymond T Kraker; Susan A Cotter; Jonathan M Holmes
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2287. doi:
Effects of subthalamic deep brain stimulation (DBS) on binocular coordination of saccades and strabismus angle in Parkinson’s disease (PD) Open Access
Palak Gupta; Sinem Balta Beylergil; Jordan Murray; Jonathan Jacobs; Aasef Shaikh; Fatema Firoz Ghasia
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2288. doi:
Neural recordings of extraocular muscle motoneurons do not show evidence for selective innervation of muscle compartments Open Access
Samuel Adade; Vallabh E Das
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2289. doi:
Amblyopia Impacts on Activity within Human V2/V3 Thin and Thick Stripes during Binocular Summation Open Access
Shahin Nasr; Bryan Kennedy; Jan Skerswetat; Nicolas Aycardi; Amanda Nabasaliza; Roger BH Tootell; Peter J Bex; David G Hunter
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2290. doi:
Metabolite and lipid biomarkers associated with intraocular pressure and inner retinal morphology: results from the UK Biobank Open Access
Louis R Pasquale; Janey L Wiggs; Anthony Khawaja; Jae Kang; Jihye Kim; Pirro G Hysi; Tobias Elze; Jessica Lasky-Su; Oana Zeleznik
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2291. doi:
An objective and easy-to-use glaucoma severity classification system based on artificial intelligence Open Access
Xiaoqin Huang; Fatemeh Saki; Mengyu Wang; Tobias Elze; Michael Boland; Louis Pasquale; Chris A Johnson; Siamak Yousefi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2292. doi:
Physiology-informed machine learning to enable precision medical approaches of intraocular pressure and blood pressure management in glaucoma Open Access
Giovanna Guidoboni; Daphne Zou; Maggie Lin; Roberto Nunez; Rajat Rai; James Keller; Christopher Wikle; Erin L. Robinson; Alice Verticchio; Brent A Siesky; Alon Harris
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2293. doi:
Forecasting Risk of Future Rapid Glaucoma Worsening Using Early Visual Field, Optical Coherence Tomography and Clinical Data Open Access
Patrick Herbert; Kaihua Hou; Chris Bradley; Michael V Boland; Pradeep Y Ramulu; Mathias Unberath; Jithin Yohannan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2294. doi:
Primary Open-Angle Glaucoma Detection with Vision Transformer: Improved Generalization Across Independent Fundus Photograph Datasets Open Access
Christopher Bowd; Rui Fan; Kamran Alipour; Mark Christopher; Nicole Brye; James A. Proudfoot; Michael Henry Goldbaum; Akram Belghith; Christopher A Girkin; Massimo A. Fazio; Jeffrey M Liebmann; Robert N Weinreb; Michael Pazzani; David Kriegman; Linda Zangwill
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2295. doi:
The Impact of Bilateral Visual Field Patterns on Quality of Life Parameters Open Access
Taibo Li; Chris Bradley; Aleksandra Mihailovic; Jasdeep Sabharwal; Pradeep Y Ramulu; Lucy Q Shen; Mengyu Wang; Jithin Yohannan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2296. doi:
Factors Involved in Developing an Open Electronic Health Record Glaucoma Dataset Open Access
Jimmy S Chen; Michael F Chiang; Michelle Hribar
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2297. doi:
α-klotho overexpression and age-related changes in mouse lenses across lifespan Open Access
Juliet A Moncaster; Douglas Parsons; Olga Minaeva; Carmela Abraham; Lee E Goldstein
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2298. doi:
ATP's Potential Role as a Hydrotrope Thereby Preventing Intralenticular Protein Aggregation Open Access
Jack V Greiner; Thomas Glonek
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2299. doi:
Looking for hidden cues: can the function of the moonlighting ocular protein βA3/A1-crystallin be regulated by the signals hidden in its coding sequence? Open Access
Nadezda A Stepicheva; Ekaterina Volkova; Victoria Koontz; PENG SHANG; Haitao Liu; Sayan Ghosh; Anastasiia Strizhakova; Olivia Chowdhury; Rachel Daley; J. Samuel Zigler; Stacey L Hose; Debasish Sinha
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2300. doi:
Creation of a semi-synthetic γS-crystallin to support studies of age-related modifications in cataract Open Access
Larry L David; Victoria S Halls; Keith Zientek; Francis I Valiyaveetil; Ravikumar Reddi; Kate A Haverson; Ujwal P Shinde; Kirsten J Lampi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2301. doi:
A Novel Method to Improve Protein Solubility and Elasticity in Aged Human Lenses Open Access
SUDIPTA PANJA; Rooban B. Nahomi; Johanna Rankenberg; Mihyun Nam; Cole R Michel; Hanmant Gaikwad; Ram H Nagaraj
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2302. doi:
Mechanism of AQP5 trafficking in lens fiber cells Open Access
Kevin L Schey; Romell B Gletten
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2303. doi:
Deamidation in human gammaS-crystallin increases susceptibility to glutathione induced oxidation and aggregation Open Access
Kirsten J Lampi; Keith Zientek; Samuel G Wheeler; David Anderson; Ujwal P Shinde; Larry L David
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2304. doi:
2-Hydrazino-4,6-dimethylpyrimidine (2-HDP) as a novel therapeutic for the neurovascular pathology of diabetic retinopathy Open Access
Josy Augustine; Evan P Troendle; Thomas Friedel; Eimear M Byrne; Paul Canning; Peter Barabas; Martin B Ulmschneider; Alan W Stitt; Tim M Curtis
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2305. doi:
THR-687, a potent pan-RGD integrin antagonist, protects against retinal vascular permeability, inflammation and reactive gliosis in the diabetic rat Open Access
Tine Van Bergen; Astrid De Vriese; Bart Jonckx; Kelly Vanhulst; Marc Vanhove; Michaël Porcu; Elke Vermassen; Philippe Barbeaux; Alan W Stitt
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2306. doi:
Association of Aqueous Retinol Binding Protein 3 (RBP3) and Diabetic Retinopathy Severity Open Access
Tanvi Chokshi; Ward Fickweiler; Margalit Mitzner; I-Hsien Wu; Tahani Boumenna; Devon Robinson; Hyunseok Park; Kyoungmin Park; Lloyd Paul Aiello; Jennifer K Sun; George King
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2307. doi:
A Phase I/IIa trial examining the safety and efficacy of BI-X in patients with diabetic macular ischemia and diabetic retinopathy: The HORNBILL study Open Access
Sobha Sivaprasad; Quan Dong Nguyen; Chirag Jhaveri; Harsha Sen; David M Brown; Raj K Maturi; Abosede Cole; Andrea Giani; Elizabeth Pearce
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2308. doi:
Maintenance of intestinal ACE2 minimizes the risk of developing diabetic retinopathy in type 1 diabetes Open Access
Ram Prasad; Jason Floyd; Bright Asare-Bediako; Dibyendu Chakraborty; Yvonne Adu-Agyeiwaah; Angela Harbour; Qiuhong Li; Maria B Grant
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2309. doi:
Intravitreal administration of AAV2-SIRT1 reverses diabetic retinopathy (DR) in a murine model of type 2 diabetes (T2D) Open Access
Maria B Grant; Yvonne Adu-Agyeiwaah; Cristiano P. Vieira; Bright Asare-Bediako; Sandra S Hammer; Sergio Li Calzi; Julia V Busik
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2310. doi:
A single cell multi-omics atlas of the human retina Open Access
Xuesen Cheng; Qingnan Liang; Jun Wang; Leah A Owen; Yumei Li; Margaret M DeAngelis; Rui Chen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2311. doi:
Single-cell analysis reveals decreased metabolism in mice with phase I ROP Open Access
Zhongjie Fu; Wenjun Yan; Jarrod C. Harman; William Allen; Edward Bull; Jay Yang; Minji Ko
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2312. doi:
Single-cell Multiomics Analysis of Human Retinal Development Open Access
Zhen Zuo; Xuesen Cheng; Yumei Li; Salma Ferdous; Jin Li; Antonio Jacobo Lopez; Ala Moshiri; Rui Chen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2313. doi:
Topological analysis of single-cell hierarchy reveals inflammatory glial landscape of macular degeneration Open Access
Brian Palmer Hafler; Manik Kuchroo; Marcello DiStasio; Eric Song; Le Zhang; Maryam Ige; Amar Sheth; Madhvi Menon; Alexander Tong; Yu Xing; Scott Gigante; Jessie Huang; George Mourgkos; Smita Krishnaswamy; Rahul Dhodapkar; Guy Wolf
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2314. doi:
Single cell RNA sequencing reveals the role of Myelin regulatory factor (MYRF) in regulating melanogenesis and cell structure during retinal pigment epithelial development. Open Access
Lev Prasov; Michelle L. Brinkmeier; Su Qing Wang; Athera Yakoo; Leonard Y. Cheung
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2315. doi:
Molecular Characterization of Neovascular AMD in Human Eyes using Spatial Transcriptomics and Single Cell RNA Sequencing Open Access
Robert F Mullins; Andrew P Voigt; Todd E Scheetz; Nathaniel Kevin Mullin; Miles J Flamme-Wiese; Li-Chun Lin; Edwin M Stone; Ian Han; Budd A. Tucker
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2316. doi:
Spatial single cell atlas of the mouse retina using MERFISH Open Access
Salma Ferdous; Jongsu Choi; Jin Li; Rui Chen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2317. doi:
Multimodal Imaging, OCT B-Scan Localization, and En face OCT Detection of Macular Hyperpigmentation in Eyes with Intermediate AMD Open Access
Rita Laiginhas; Jeremy Liu; Mengxi Shen; Yingying Shi; Omer Trivizki; Nadia K Waheed; Giovanni Gregori; Philip J Rosenfeld
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2318. doi:
Automated detection of morphologic changes on SD-OCT leading toward outer retinal atrophy in intermediate age-related macular degeneration in the prospective PINNACLE trial Open Access
Sophie Riedl; Wolf-Dieter Vogl; Oliver Leingang; Hrvoje Bogunovic; Lars Fritsche; Toby Prevost; Daniel Rueckert; Hendrik P Scholl; Sobha Sivaprasad; Andrew J Lotery; Ursula Schmidt-Erfurth
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2319. doi:
Prospective, longitudinal feasibility study: daily self-imaging with home OCT in neovascular age-related macular degeneration Open Access
Yingna Liu; Nancy M Holekamp; Jeffrey S Heier
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2320. doi:
Quantification of lesion progression of incomplete and complete retinal pigment epithelium and outer retinal atrophy in age-related macular degeneration Open Access
Steffen Schmitz-Valckenberg; Marlene Sassmannshausen; Martina Braun; Verena Steffen; Simon S Gao; Lee Honigberg; Daniela Ferrara; Maximilian Pfau; Frank G Holz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2321. doi:
Adaptive optics phenotypes of intermediate age-related macular degeneration Open Access
Ahmed M Hagag; Sophie Riedl; Toby Prevost; Lars Fritsche; Daniel Rueckert; Hendrik P Scholl; Ursula Schmidt-Erfurth; Sobha Sivaprasad; Andrew J Lotery
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2322. doi:
Does outer retinal thickness represent another clinical biomarker for predicting geographic atrophy growth? Open Access
Ruikang K Wang; Qinqin Zhang; Zhongdi Chu; Yuxuan Cheng; Hao Zhou; Yingying Shi; Mengxi Shen; William J Feuer; Giovanni Gregori; Philip J Rosenfeld
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2323. doi:
Ratio of photoreceptor to retinal pigment epithelium loss as an important predictor of GA growth and therapeutic efficacy Open Access
Ursula Schmidt-Erfurth; Sophie Riedl; Wolf-Dieter Vogl; Julia Mai; Gregor Sebastian Reiter; Dmitrii Lachinov; Christoph Grechenig; Alex McKeown; Lukas Scheibler; Hrvoje Bogunovic
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2324. doi:
The Most Influential Articles on Artificial Intelligence in Ophthalmology Open Access
Maxine Joly-Chevrier; Anne Xuan-Lan Nguyen; Isabelle Hardy
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2325. doi:
Automated Machine learning models applied to Optical Coherence Tomography Angiography for detection and classification of Diabetic Retinopathy in Diabetes Mellitus type 1 Open Access
Maximiliano Olivera; Carolina Bernal-Morales; Anibal Alé-Chilet; Marina Barraso; Sara Marin; Silvia Feu; Josep Rosinés; Cristian Oliva; Teresa Hernandez; Irene Vila; Robbert Struyven; Mariana Batista-Gonçalves; Siegfried Wagner; Pearse Andrew Keane; Javier Zarranz-Ventura
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2326. doi:
Leveraging unlabeled OCT data for training better deep learning vision-transformer models Open Access
Theodore Spaide; Yelena Bagdasarova; Cecilia S Lee; Aaron Y Lee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2327. doi:
Predicting contrast sensitivity functions with digital twins generated by Hierarchical Bayesian modelling Open Access
Zhong-Lin Lu; Yukai Zhao; Luis A Lesmes; Michael Dorr
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2328. doi:
Federated learning for collaborative clinical diagnosis and disease epidemiology in retinopathy of prematurity Open Access
Adam H Hanif; Charles Lu; Ken Chang; Praveer Singh; Aaron S Coyner; James Brown; Susan Ostmo; R.V. Paul Chan; Daniel Rubin; Michael F Chiang; Jayashree Kalpathy-Cramer; J. Peter Campbell
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2329. doi:
Detection of graft failure in post-keratoplasty patients by Automated Deep Learning Open Access
Carlos Mendez Mangana; Anton Barraquer Kargacin; Jorge Fernandez-Engroba; Pedro Taña; Gil Santolaria; Maximiliano Olivera; Rafael I Barraquer
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2330. doi:
THE USE OF SMARTPHONES FOR THE COLLECTION OF DIGITAL HABITS BIG DATA AND ITS CORRELATION WITH CLINICAL REFRACTION IN A UNIVERSITY POPULATION Open Access
Norberto Lopez-Gil; Rosa Salmerón-Campillo; Andres Gonzalez-Diaz; David Zarzoso-Fernandez; David Aparicio; Matt Jaskulski
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2331. doi:
A first in class Virus-Like Drug Conjugate (VDC) shows anti-tumor activity in Cancers that Commonly Metastasize to the Choroid Open Access
Anneli Savinainen; Rhonda Kines; Cadmus C Rich
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2616. doi:
Role of exosomes in liver metastasis of uveal melanoma Open Access
Angels Fabra; Raquel Ramos; Eduard Cabré; Antonia Vinyals; Jose Maria Caminal; J Vaquero; Daniel Lorenzo; Josep M. Piulats; Montse Gomá; Cristina Gutierrez; Ester Gonzalez Sanchez; I. Fabregat
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2617. doi:
Metabolic expression patterns from peripheral blood distinguish between low and high risk of metastasizing in uveal melanoma Open Access
Daniel de Bruyn; Michiel Bongaerts; Dion Paridaens; Nicole Naus; Annelies de Klein; Emine Kilic; Erwin Brosens
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2618. doi:
pRB-depleted pluripotent stem cell retinal organoids mimic retinoblastoma development Open Access
Agata Rozanska; Rodrigo Cerna-Chavez; Rachel Queen; Joseph Collin; Darin Zerti; Birthe Dorgau; Chia Shyan Beh; Tracey Davey; Jonathan Coxhead; Rafiqul Hussain; Jumana Al-Aama; David Steel; Nissim Benvenisty; Lyle Armstrong; Manoj Parulekar; Majlinda Lako
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2619. doi:
Development of a preclinical model of retinoblastoma in rats mimicking different clinical presentations Open Access
Denis Malaise; François Doz; Nathalie Cassoux; Carole Thomas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2620. doi:
FOXD1 is involved in uveal melanocyte development and associated with high-risk uveal melanoma Open Access
Quincy van den Bosch; Josephine Nguyen; Tom Brands; Thierry van den Bosch; Robert Verdijk; Dion Paridaens; Nicole Naus; Annelies de Klein; Emine Kilic; Erwin Brosens
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2621. doi:
Single cell characterization reveals more frequent IGHV3 and IGHV4 gene usage and the correlation with MYD88 mutation in primary vitreoretinal lymphoma Open Access
Meng Wang; Tong Seng Lim; Nagavalli DO Somasundaram; Meihui Wu; Anita Chan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2622. doi:
Identification of autosomal recessive novel genes and retinal phenotypes in members of the solute carrier (SLC) superfamily Open Access
Dror Sharon; Talya Millo; Jose Antonio Rivera; Alexey Obolensky; Dvorah Marks-Ohana; Enosh Wilhelm; Prakadee Gopalakrish; Menachem Gross; Boris Rosin; Mor Hanany; Anna Maria Tracewska; Ora Schueler-Furman; Susanne Roosing; Eyal Banin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2623. doi:
Phenotype-Based Genetic Analysis Reveals Missing Heritability of ABCA4-Related Retinopathy: Deep Intronic Variants and Copy Number Variations Open Access
Tian Lu; Chunjie Chen; Yuning Song; Xiaohui Zhang; Ke Xu; Yue Xie; Zi-Bing Jin; Yang Li
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2624. doi:
BMPR1B identified as a novel human ocular coloboma gene through cross-species meta-analysis Open Access
Nicholas Owen; Maria Toms; Rodrigo M Young; Jonathan Eintracht; Hajrah Sarkar; . Genomics England Research Consortium; Brian Brooks; Mariya Moosajee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2625. doi:
Genetic analysis of familial AMD cohort identifies genes associated with disease susceptibility Open Access
Lina Zelinger; Tammy M Martin; Jayshree Advani; Milton English; Alan Kwong; Claire Malley; Jennifer Maykoski; YURI SERGEEV; Robert N Fariss; Emily Y Chew; Michael L Klein; Anand Swaroop
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2626. doi:
Spatial modeling of variants in complement genes associated with age-related macular degeneration Open Access
Michelle Grunin; Sarah de Jong; Ellen Palmer; Bowen Jin; David Rinker; Christopher Moth; John A Capra; Jonathan L Haines; William S Bush; Anneke I Den Hollander
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2627. doi:
Identification and characterization of a novel retina-specific lncRNA upstream ABCA4 with a potential role in ABCA4-associated inherited retinal disease Open Access
Alfredo Dueñas Rey; Víctor López-Soriano; Zelia Corradi; Claire-Marie Dhaenens; Manon Bouckaert; Jasper Verwilt; Avril M Watson; Majlinda Lako; Eva D’haene; Karla Alejandra Ruiz Ceja; Sandro Banfi; Miriam Bauwens; Frans P Cremers; Steve Lefever; Elfride De Baere; Frauke Coppieters
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2628. doi:
Integrated multi-omics analysis to dissect a cis-regulatory role of ultraconserved non-coding elements (UCNEs) in human developing and adult retina Open Access
Víctor López-Soriano; Alfredo Dueñas Rey; Stijn Van de Sompele; Frauke Coppieters; Andrew R Webster; Miriam Bauwens; Elfride De Baere
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2629. doi:
Breast, Cervical and Colorectal Cancer Screening among Canadians with and without Self-Reported Visual Impairment Open Access
Milena Cioana; James H.B. Im; Yvonne Buys; Hatem Krema; Sophia Liu; Peng Yan; Yaping Jin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2630. doi:
Skin Carotenoid Assessment to Detect Vitamin A Deficiency in Children and Pregnant Women in Nepal Open Access
Raba Thapa; Sanduk Ruit; Emmanuel Kofi Addo; Paul S Bernstein
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2631. doi:
Impact of indeterminant ranges around the cut-off for antibody positivity on the use of serology for trachoma monitoring Open Access
Xinyi Chen; Beatriz Munoz; Harran Mkocha; Charlotte Gaydos; Laura Dize; Thomas Quinn; Sheila K West
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2632. doi:
Preterm birth and ophthalmological impairments at 51/2 years: EPIPAGE-2 cohort study. Open Access
thibaut Chapron; Véronique Pierrat; Georges Caputo; Mathilde Letouzey; Elsa Kermorvant; Amandine Barjol; Guylene Le Meur; Valérie Benhamou; Laetitia Marchand-Martin; Pierre-Yves Ancel; Héloïse Torchin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2633. doi:
Adherence to the Mediterranean Diet and Geographic Atrophy Enlargement Rate in the Age-Related Eye Disease Study 2 Open Access
Tiarnan D L Keenan; Elvira Agron; Julie A Mares; Emily Y Chew
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2634. doi:
The International Globe and Adnexal Trauma Epidemiological Eye Study (IGATES) registry. Open Access
Annette K Hoskin; Yunia Irawati; Mehul Shah; Prem S Subramanian; Mohammad Soleimani; Alok Sen; Sundaram Natarajan; Jose Dalma; Eli Pradhan; Apoorva Ayachit; Dr Giridhar; Manisha Agarwal; Amer Awan; Kasturi Bhattacharjee; Stephanie L Watson; Rupesh Vijay Agrawal
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2635. doi:
Dynamic Prediction Model for Treatment-requiring Retinopathy of Prematurity Open Access
Gui-Shuang Ying; Yinxi Yu; Gil Binenbaum
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2636. doi:
BMP3 suppresses embryonic corneal myofibroblast phenotype by promoting focal adhesion turnover and αSMA fiber disassembly Open Access
Peter Lwigale; James Spurlin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2637. doi:
A biomimetic hydrogel-based therapeutic approach for preventing corneal scarring Open Access
Vivek Singh; Shibu Chameettachal; Animith Venuganti; Yash Parekh; Deeksha Prasad; Abhishek Sahoo; Kiran Bokara; Falguni Pati; Sayan Basu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2638. doi:
In-Situ Repair of Corneal Stroma using A Light-Curable Hydrogel from Porcine Corneal Extracellular Matrix Open Access
Ali R Djalilian; Ghasem Yazdanpanah; Xiang Shen; Tara Thanh Nguyen; Khandaker Anwar; Oju Jeon; Yizhou Jiang; Mohammad Pachenari; Yayue Pan; Tolou Shokuhfar; Mark Rosenblatt; Eben Alsberg
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2639. doi:
Epigenetic mechanism to induce dedifferentiation of corneal myofibroblast to fibroblast Open Access
Rajiv R Mohan; Praveen Kumar Balne; Nishant Rajiv Sinha; Alexandria Hofmann; Nicholas Hauser; Ratnakar Tripathi; Prashant Sinha; Suneel Gupta; Kempuraj Duraisamy
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2640. doi:
Novel hyaluronic acid-based corneal stromal replacement Open Access
Alfonso Iovieno; Roza Ghaemi; Vikramaditya Yadav; Sonia Yeung
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2641. doi:
Latent Transforming Growth Factor-β Binding Protein 1 expression in the corneal stroma Open Access
Edgar M Espana; Sarah Salvatori; Mei Sun; Devon Cogswell
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2642. doi:
Schlemm’s Canal Outflow Resistance System (SCORS) visualized by Clarification and Immunohistochemistry (IHC) Open Access
Elizabeth Martin; Murray A Johnstone
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2643. doi:
SMAD4-β-catenin nuclear complex inhibits TGFβ2-induced pathological changes in the trabecular meshwork. Open Access
Chenna Kesavulu Sugali; Naga pradeep Rayana; Jiannong Dai; Weiming Mao
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2644. doi:
Understanding the requirement of AP-2β in development of the Trabecular Meshwork Open Access
Aftab Taiyab; Japnit Dham; Fatima Shirazee; Monica Akula; Trevor Williams; Judith A West-Mays
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2645. doi:
Therapeutics of stem cell secretome in dexamethasone-induced ocular hypertension mice Open Access
Yiqin Du; Ajay Kumar
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2646. doi:
Spatial cluster analysis reveals how segmental outflow patterns change over time in living mice Open Access
Darryl R Overby; Tiffany Baptiste; Daniel Duffill; Ester Reina-Torres
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2647. doi:
Clusterin modulates IOP homeostasis by regulating the actin cytoskeleton and attenuating profibrotic responses in TM Open Access
Avinash Soundararajan; Padmanabhan P Pattabiraman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2648. doi:
Role of Septins in Regulation of Actin Cytoskeletal Organization in Trabecular Meshwork Cells Open Access
Pallavi Gorijavolu; Rupalatha Maddala; William Bachman; Nikolai P Skiba; Rakesh K. Singh; Vasantha Rao
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2649. doi:
Changes in Optic Nerve Glia Induced by Astrocyte-specific Deletion of STAT3 Open Access
Paul F Cullen; Daniel Sun
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2650. doi:
Astrocytes of the optic nerve head in pig and human eyes have no aquaporin channels Open Access
Harry A Quigley; Casey Keuthan; Mary Pease; Elizabeth Kimball
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2651. doi:
Inflammation modulates regeneration following acute or chronic retinal damage in zebrafish Open Access
Maria Iribarne; David Hyde
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2652. doi:
Single-cell RNA sequencing analysis of neurogenic competence in Müller glia in a rabbit retinal injury model Open Access
Clayton Pio Santiago; Megan Gimmen; Yuchen Lu; Ying Xin; Minda McNally; Tyler Creamer; Linda Orzolek; Thomas Zollner; William Schubert; Khaled Nassar; Charles Eberhart; Jiang Qian; Seth Blackshaw; Mandeep Singh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2653. doi:
Non-random cellular distribution of the mitochondrial 3243A>G variant in the human retina and choroid and its impact on disease phenotype. Open Access
Nathaniel Kevin Mullin; Andrew P Voigt; Miles J Flamme-Wiese; Xiuying Liu; Kelsey L Wieland; Edwin M Stone; Budd A. Tucker; Robert F Mullins
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2654. doi:
Retinoschisin deficiency induces persistent aberrant waves of activity affecting neuroglial signaling in the developing retina Open Access
Cyril Eleftheriou; Carlo Corona; Shireen Khattak; Elena Ivanova; Paola Bianchimano; Yang Liu; Duo Sun; Rupesh Singh; Julia Batoki; J Jason McAnany; Neal S Peachey; Carl Romano; Botir Sagdullaev
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2655. doi:
A chronic proinflammatory retinal microenvironment progresses neurodegeneration in a spontaneous model of inherited retinal dystrophy Open Access
TJ Hollingsworth; Xiangdi Wang; William White; Usman Baguda; Raven Simpson; Monica M Jablonski
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2656. doi:
Improving detection of depression in adults with vision impairment Open Access
Edine van Munster; Claire Nollett; Edith Holloway; Ruth M A van Nispen; Otto Maarsingh; Martijn Heymans; Hilde Petronella Adriana van der Aa
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2657. doi:
Mediating factors in the link between visual impairment and psychiatric disorders Open Access
Tyler Pfister; Jo Ellen Wilson; Lindsey McKernan; Sapna Gangaputra
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2658. doi:
Prevalence of Charles Bonnet syndrome among UK visually impaired military veterans and associated impact of visual hallucinations during the COVID-19 pandemic Open Access
Lee Jones; Matthew Lee; Renata Gomes; Mariya Moosajee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2659. doi:
Impact of COVID-19 on healthcare access for older adults with combined hearing and vision loss: A Canada-wide survey of healthcare workers Open Access
Atul Jaiswal; Peter Holzhey; Shreya Budhiraja; Abinethaa Paramasivam; Sangeetha Santhakumaran; Norman Robert Boie; Marie Savundranayagam; Claude Vincent; Edeltraut Kröger; Walter Wittich
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2660. doi:
An Evolution of Telerehabilitation for Low Vision Follow-ups Open Access
Ava K Bittner; Nicole Ross
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2661. doi:
Developing a care delivery framework for older adults with chronic eye disease and vision impairment: A mixed methods study on patient perspectives Open Access
Fahd Naufal; Xinxing Guo; Catherine Kerr-Niermann; Judith E Goldstein
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2662. doi:
Psychometric validation of patient-reported outcome (PRO) and observer-reported outcome (ObsRO) measures in Retinitis Pigmentosa and Leber Congenital Amaurosis Open Access
Isabelle S Audo; Nicola Williamson; Melissa Barclay; Joel Sims; Kieran Boparai; Francesco Patalano; Christel Naujoks; Claudio Spera; Judit Banhazi; Paul O’Brien; Christine Kay; Jane Green; Todd Durham; Helena Bradley; M Dominik Fischer
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2663. doi:
Association of retinal fractal dimension with incident cardiovascular events in a hospital-attending population in London, United Kingdom Open Access
Siegfried Wagner; Robbert Struyven; Mario Cortina-Borja; Alastair K Denniston; NIKOLAS PONTIKOS; Emanuele Trucco; Muthu Rama Krishnan Mookiah; Konstantinos Balaskas; Axel Petzold; Jugnoo Rahi; Pearse Andrew Keane
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2664. doi:
A Novel Approach to Estimating Choroidal Lesion Thickness Using 2D Optomap Images Open Access
Michael Yu; Michael Heiferman; Edward Korot; Prithvi Mruthyunjaya
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2665. doi:
Retinal vascular features as new biomarkers for aortic aneurysms and aortic dissections Open Access
Yu Huang; Danli Shi; Xiayin Zhang; Zhuoting Zhu; Xueli Zhang; Shulin Tang; Xianwen Shang; Cong Li; Mingguang He
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2666. doi:
Late hyperfluorescent plaque in type 1 choroidal neovascularization in age-related macular degeneration and central serous chorioretinopathy Open Access
Marta Zola; Elodie Bousquet; Catherine Favard; Anthony Gigon; Irmela Mantel; Francine F Behar-Cohen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2667. doi:
Proliferation of intraretinal vessels and disease progression in Macular Telangiectasia Type 2 (MacTel) Open Access
Lukas Goerdt; Kristina Hess; Philipp Herrmann; Frank G Holz; Simone Tzaridis
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2668. doi:
Novel retinopathy in pediatric retinal vasculitis: long term follow up Open Access
Cigdem Yasar; Hashem Ghoraba; Jonathan Regenold; Chi Mong Or; Muhammad Sohail Halim; Gunay Uludag; Jaclyn Hwang; Irmak Karaca; Azadeh Mobasserian; Amir Akhavanrezayat; Mimbay Yasar; Hassan Khojasteh; Yasir J. Sepah; Diana V Do; Quan Dong Nguyen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2670. doi:
Evaluating the Risk of Retinal Vascular Occlusion among COVID-19 patients Open Access
Haig Pakhchanian; Rahul Raiker; Masumi Asahi; Don Pham; Alison Hong; Monica Dalal
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2671. doi:
Visit Adherence and Visual Acuity in SCORE2 Open Access
Brian L VanderBeek; Yinxi Yu; Neal Oden; Paul C Van Veldhuisen; Barbara A Blodi; Michael S Ip; Ingrid U Scott
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2672. doi:
Predicting outcomes and treatment frequency following monthly intravitreal aflibercept for macular edema secondary to central retinal vein occlusion: a machine learning model approach Open Access
Nitish Mehta; Yasha Modi; Weiming Du; Fabiana Q Silva; Hadi Moini; Rishi P Singh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2673. doi:
36-month outcomes of VEGF inhibitors for treatment-naïve Central Retinal Vein Occlusion: Data from the Fight Retinal Blindness! registry. Open Access
Adrian Hunt; Vuong Nguyen; Sanjeeb Bhandari; Jennifer J Arnold; Ian McAllister; Hemal Mehta; Alessandro Invernizzi; David Squirrell; Theodorus Ponsioen; Pierre-Henry GABRIELLE; Louise O’ Toole; Javier Zarranz-Ventura; Daniel Barthelmes; Mark C Gillies
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2674. doi:
A novel HIF1α inhibitor KC7F2 attenuates oxygen-induced retinal neovascularization Open Access
Xiaoyu Tang; Kaixuan Cui; Peiqi Wu; Yue Xu; Xiaoling Liang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2675. doi:
Systemic and Laboratory Risk Factors for Retinopathy and Detection of Tear Film SARS-CoV-2 RNA Open Access
Jessica Shantha; Tolulope Fashina; Victoria Simmons; Casey Randleman; Laura Ward; Matthew Regueiro; Susanne Linderman; Carolyn Drews-Botsch; Rafi Ahmed; Jesse Waggoner; Steven Yeh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2676. doi:
Deletion of Angiotensin II type 2 receptor (AT2) exacerbates retinal neovascularization and hemorrhage in oxygen-induced retinopathy (OIR) Open Access
Kevin Harkin; Pietro Bertelli; Hazal Yilmaz; Paul Canning; Ana Rodriguez; Thomas Walther; Alan W Stitt
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2677. doi:
A phase 2 randomized controlled trial of the Janus Kinase (JAK) inhibitor filgotinib in patients with noninfectious uveitis Open Access
Sunil K Srivastava; Tim Watkins; Quan Dong Nguyen; Sumit Sharma; David Scales; Mark Dacey; Rajiv E Shah; David Chu; Dilraj S Grewal; Lisa Faia; Eric B Suhler; Mark Genovese; Ying Guo; William Barchuk; Andrew D Dick; James T Rosenbaum
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2678. doi:
High dimensional profiling and immune monitoring of Uveitis patients Open Access
Pulak Ranjan Nath; Mary Maclean; Jung Lee; Aman Kumar; Hadi Nadali; Mehmet Yakin; Shilpa Kodati; Vijayraj Nagarajan; Koray Kaya; Rachel R Caspi; Jonas J.W. Kuiper; H. Nida Sen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2679. doi:
Antigen-driven immune responses distinguish uveitis subtypes. Open Access
Lynn Hassman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2680. doi:
Kinetics of rolling and crawling immune cells in retinal venules during inflammation imaged with label-free adaptive optics ophthalmoscopy Open Access
Kosha Dholakia; Colin J Chu; Jesse Schallek
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2681. doi:
A novel and distinct TIGIT-dependent Treg subset provides resistance to relapsing uveitis through suppression of Th17 cells Open Access
Darren J Lee; Trisha McDonald; Kayleigh Peters
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2682. doi:
Growth Hormone releasing hormone (GHRH) promotes autoimmune uveitis by enhancing Th17 cell differentiation Open Access
Lin DU; Jian Li; Bo Man Ho; Yolanda Wong Ying Yip; Sun On Chan; Calvin C P Pang; WAI KIT CHU
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2683. doi:
MHC class II positive retinal microglia exacerbate uveitis by activating infiltrating T cells Open Access
Shintaro Shirahama; May Yue Lee; Yoko Okunuki; Kip M Connor; Meredith S Gregory-Ksander; Bruce Ksander
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2684. doi:
Enhanced S-Cone Syndrome gives rise to enhanced S-cone acuity Open Access
Yiyi Wang; Jessica Wong; Jacque L Duncan; Austin Roorda; William Scott Tuten
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2685. doi:
Multimodal high-resolution imaging of retinal function in Retinitis Pigmentosa Open Access
Ben J Wendel; Vimal Prabhu Pandiyan; Xiaoyun Jiang; Ayoub Lassoued; Emily Slezak; William Scott Tuten; Debarshi Mustafi; Jennifer R Chao; Ramkumar Sabesan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2686. doi:
Reliability and Reciprocity of the Population Cone Optoretinogram Open Access
Raymond Luval Warner; David H Brainard; Jessica Ijams Wolfing Morgan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2687. doi:
Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO) Measures in MERTK-Related Retinal Degenerations Open Access
Stephanie Duret; Jessica Wong; Hao Zhou; Ruikang K Wang; Jacque L Duncan; Austin Roorda
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2688. doi:
Characterization of fluorescently labeled photoreceptors observed in carriers of choroideremia using multimodal adaptive optics imaging Open Access
Andrew J. Bower; Nancy Aguilera; Sarah Abouassali; Tao Liu; Joanne Li; Rongwen Lu; John Giannini; Margery Smelkinson; Robert N Fariss; Alfredo Dubra; Zhuolin Liu; Daniel Hammer; Brian Patrick Brooks; Wadih M Zein; Laryssa Huryn; Johnny Tam
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2689. doi:
Detecting inflammatory cells in patients with Multiple Sclerosis using AO-SLO phase contrast imaging Open Access
Elena Gofas; Celine Louapre; Nathaniel Norberg; Ysoline Beigneux; Michel Paques; Catherine Vignal Clermont; Kate Grieve
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2690. doi:
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY ANALYSIS OF THE CORIO-RETINAL MICROVASCULAR INVOLVEMENT IN SYSTEMIC SCLEROSIS Open Access
Gloria Gambini; Tomaso Caporossi; Umberto De Vico; Matteo Mario Carlà; Maria Cristina Savastano; Antonio Baldascino; Silvia Fiore; Enrico De Lorenzis; Silvia Bosello; Stanislalo Rizzo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2691. doi:
Phototranduction noise in rods controlling visual detection threshold. Open Access
Ulisse Bocchero; Lior Levy; Johan Pahlberg
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2692. doi:
Characterization of cone membrane physiology during secondary cone degeneration in the rd10 model of retinitis pigmentosa Open Access
Erika Ellis; Gordon Fain; AP Sampath
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2693. doi:
Deciphering the Role of bII-spectrin in the Developing Outer Retina Open Access
Debalina Goswami-Sewell; Caitlin Bagnetto; Elizabeth Zuniga-Sanchez
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2694. doi:
Upregulation of Rod Ribbon Synapse Components Coincides with Well-preserved Scotopic Vision in the P23H Model of Retinitis Pigmentosa Open Access
Frans Vinberg; Fatima Abbas; Elliot H Choi; Marcin Tabaka; Umair Seemab; Krzysztof Palczewski; Henri Olavi Leinonen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2695. doi:
Role of LRFN2 in synaptic function of cone photoreceptors in mouse retina Open Access
Nazarul Hasan; Ronald G Gregg
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2696. doi:
Hybrid rod-cone anatomical characteristics revealed in the ultrastructural features and synaptic architecture of the functionally plastic pure-rod retina Open Access
Laura Magana Hernandez; Emma Alvarez; David Umbertus; Julio Robles; Erin Rose; Daniel Brown; Ivan Anastassov
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2697. doi:
Fat3 deficiency impairs bipolar cell function and fast vision in mice Open Access
Yunlu Xue; Evelyn Avilés; Vladimir Kefalov; Lisa Goodrich; Connie Cepko
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2698. doi:
Vision impairment and Dementia: Economic hardships for patients and caregivers Open Access
Varshini Varadaraj; Matthew Eisenberg; Emmanuel Garcia-Morales; Nicholas Reed; Orla Sheehan; Bonnielin K Swenor
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3084. doi:
A decision analytic economic model for use in glaucoma management Open Access
Shefali Sood; Noah Heilenbach; Victor Sanchez; Lama A Al-Aswad
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3085. doi:
Cost-Effectiveness Analysis of Personalized Diabetic Retinopathy Screening Recommendations Open Access
Poria Dorali; Zahed Shahmoradi; Christina Y Weng; Taewoo Lee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3086. doi:
Gender-based differences in Medicare reimbursements among ophthalmologists persist across time Open Access
Omar Halawa; Sayuri Sekimitsu; Michael V Boland; Nazlee Zebardast
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3087. doi:
Developing a care delivery framework for older adults with visual impairment: A mixed methods study on ophthalmologist perspectives Open Access
Judith E Goldstein; Catherine Kerr-Niermann; Fahd Naufal; Xinxing Guo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3088. doi:
State-level differences in duties permitted to be performed by medical assistants in the delivery of eye care Open Access
Mary-Grace Reeves; Jiayin Xue; Arnold Milstein; Geoff Tabin; Jeffrey L Goldberg; Kevin Schulman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3089. doi:
Evaluating access to laser therapy by driving distance using Medicare data and Geographic Information Systems mapping Open Access
Jamie Shaffer; Darby D Miller; Aaron Y Lee; Cecilia S Lee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3090. doi:
Loss of macrophage chemoattractant protein-1 reduces retinal inflammation and neuron death in hypertensive glaucoma Open Access
Michelle Guo; Turner D Schwartz; Jacob Sterling; Jie Wu; Ahab Alnemri; Modupe Adetunji; Emily Lawrence; Ahmara G Ross; Joshua L Dunaief; Qi N Cui
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3091. doi:
RNAi BASED APPROACH FOR MYOC-ASSOCIATED GLAUCOMA Open Access
Gaurang Patel; Brijeshkumar Patel; Charleen Hunt; Sarthak R Zaveri; Sabrina Walley; rajeevalochan wudali; Sven-Moller Tank; James Mcninch; Mark Schlegel; Adam Castoreno; Elena Castellanos-Rizaldos; Abigail Liebow; Kavita Praveen; Ying Hu; Vasant Jadhav; Carl Romano
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3092. doi:
Exfoliation syndrome (XFS): Production of extracellular aggregates in a human capsulorhexis culture model Open Access
Terete Borras; David Fleischman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3093. doi:
Multipolar migration and the SDF1-CXCR4 axis direct human retinal ganglion cell integration in mice Open Access
Jonathan Soucy; Monichan Hayes Phay; Petr Y Baranov
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3094. doi:
Correlating longitudinal Optical Coherence Tomography (OCT) structural change to retrolaminar myelin-related protein alteration in non-human primate (NHP) early experimental glaucoma (EG) Open Access
Hongli Yang; Priya Chaudhary; Cheri Stowell; Juan Reynaud; Stuart Keith Gardiner; Galen Williams; Imee Williams; Nicholas Marsh-Armstrong; Claude F Burgoyne
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3095. doi:
Extracellular Matrix Remodeling of Human Trabecular Meshwork Cells in Static and Dynamic Biopolymer Scaffolds Open Access
Bikram Adhikari; Melissa Krebs; Mina B Pantcheva
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3096. doi:
Astrocyte Morphology in the Collagenous Lamina Cribrosa Revealed by Multicolor DiOlistic Labeling Open Access
Susannah Waxman; Marissa Quinn; Cara Donahue; Siamak Salavatian; Aman Mahajan; Louis Falo; Daniel Sun; Ian Sigal
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3097. doi:
Improved Prediction of Perimetric Loss in Glaucomatous Eyes Using Latent Class Mixed Modeling Open Access
Swarup Sai Swaminathan; Alessandro A Jammal; Felipe Medeiros
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3098. doi:
Comparison of Rates of Change in 10-2 and 24-2 Perimetry to Detect Glaucoma Progression Open Access
Ndidi-Amaka Onyekaba; Alessandro A Jammal; Tais Estrela; Rizul Naithani; Asmaa Youssif; Henry Tseng; Felipe Medeiros
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3099. doi:
Using Moving instead of Static Stimuli to Extend the Dynamic Range of Perimetry Open Access
Stuart Keith Gardiner; Steven L Mansberger
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3100. doi:
Investigating the Impact of Blur on Virtual Reality Perimetry Open Access
Brett King; William H Swanson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3101. doi:
Learning curve on tablet-based visual field tests during one week of daily testing Open Access
Sofía De Arrigunaga; Joyce Kang; Yan Zhao; Sandra Freeman; Ana M. Roldan; Tobias Elze; Michael M. Lin; Daniel Liebman; Dolly Chang; David S Friedman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3102. doi:
Comparison of a virtual reality-based visual field test to conventional perimetry and OCT Open Access
Zer Keen Chia; Alan W Kong; Marcus Lawrence Turner; Benjamin T Backus; Michael Deiner; Yvonne Ou
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3103. doi:
Diagnostic accuracy of an iPad application for detection of visual field defects Open Access
Quintin Richardson; Rajesh S. Kumar; B Ramgopal; Mahalakshmi V Rackenchath; Sathi Devi A V; Sriharsha Nagaraj; Caitlin A Moe; Dionna M Wittberg; Kieran S O'Brien; Robert L Stamper; Jeremy D Keenan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3104. doi:
The adult human lens transcriptome changes with age Open Access
Melinda K Duncan; Adam Faranda; Samuel G Novo; Justin d'Antin; Yan Wang; Mahbubul H Shihan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3105. doi:
Mechano-activated Connexin Hemichannels and Glutathione Transport Protect Lens Fiber Cells against Oxidative Insults Open Access
Jean Jiang; Yuxin Tong; Manuel Riquelme; Yu Du; Yumeng Quan; Sumin Gu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3106. doi:
Circadian rhythms and glutathione homeostasis in the rat lens Open Access
Julie C Lim; Haruna Suzuki-Kerr; Tai Nguyen; Christopher Lim; Raewyn C Poulsen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3107. doi:
Lamin phosphorylation directs nuclear condensation and nuclear envelope reorganization during lens differentiation Open Access
Elizabeth A Whitcomb; Giuliana Perini-Villanueva; Sarah Francisco; Marc Kantorow; Lisa A Brennan; Paul G FitzGerald; Allen Taylor
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3108. doi:
Distinct changes of aquaporins in Connexin 50 knockout and MEK1 transgenic lens epithelial cells Open Access
Chun-hong Xia; William Lin; Chenxi Ou; Tom Zhang; Isaac Xu; Xiaohua Gong
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3109. doi:
Small molecule movement in the bovine lens – comparing and contrasting nutrient and pharmaceutical uptake and metabolism with MALDI mass spectrometry Open Access
Angus C Grey; George Guo; Kyriakos Varnava; Ali Zahraei; Melody Tang; Nicholas Demarais; Paul J Donaldson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3110. doi:
Differential Expression of the Major Components of the cGAS/STING Pathway in Normal Human Lens and Cataractous patients Open Access
Yan Wang; Jialing Fu; Shuyu Zheng; yuan xiao; Jingmiao Wang; Ling Wang; Jiawen Xiang; David W Li
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3111. doi:
In vivo flow cytometry in retina to study rare blood cells Open Access
Jin won Huh; Kosha Dholakia; Derek Power; Jesse Schallek
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3112. doi:
Clarifying the roles of high and low blood pressure in glaucoma via physiology-informed machine learning Open Access
Roberto Nunez; Alon Harris; Marcela Szopos; Rajat Rai; James Keller; Christopher Wikle; Erin L. Robinson; Maggie Lin; Daphne Zou; Alice Verticchio; Brent A Siesky; Giovanna Guidoboni
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3113. doi:
Apoptosis and necroptosis is induced in cone photoreceptor cells subjected to cold storage and rewarming Open Access
Swati Jain; Dor Yoeli; Neil Khatter; An-Jey Su; Evan Farkash; Christene Huang; Kia Washington; Alkesh Jani
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3114. doi:
A novel function for IL-36 cytokines enhancing retinal endothelial cell barrier integrity Open Access
Erin Fahey; Lucia Celkova; Conor Delaney; Patrick T Walsh; Seamus J Martin; Matthew Campbell; Sarah L Doyle
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3115. doi:
Oncostatin M reduces hypoxia-induced retinal neovascularization through Müller cell activation Open Access
Felicitas Bucher; Julian Rapp; Paula Liang; Gunther R Schlunck; Hansjüergen T Agostini
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3116. doi:
Effect of the ATP-sensitive potassium channel opener diazoxide on retinal vessel diameter of C57BL/6J mice Open Access
Uttio Roy Chowdhury; Michael P Fautsch
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3117. doi:
Conversion Rates from Non-exudative to Exudative Age-Related Macular Degeneration: An AAO IRIS Registry Analysis Open Access
Connor Ross; Dan Gong; Nathan Hall; Tobias Elze; Lucia Sobrin; Joan W Miller; Alice Lorch; John B Miller
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3118. doi:
Clinical outcome of a modified treat-and-extend protocol in the treatment of neovascular age-related macular degeneration. Open Access
Brice Nguedia Vofo; Yaacov Cnaany; Itay Chowers
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3119. doi:
Faricimab in neovascular age-related macular degeneration: updated week 48 efficacy, safety, and durability in the phase 3 TENAYA and LUCERNE trials Open Access
Nikolas London; Robyn H Guymer; Anna-Maria Demetriades; Carlos Quezada Ruiz; David Silverman; Jane Ives; Karen Basu; Hugh Lin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3120. doi:
Archway phase 3 trial of the Port Delivery System with ranibizumab (PDS) for neovascular AMD: end-of-study results Open Access
ROBERT MITTRA; Logan Brooks; Charles Wykoff; Natalia Callaway; Stephanie DeGraaf; Anne Fung; Shamika Gune; Sophie LePogam; Robert Smith; Jeffrey Willis; Giulio Barteselli
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3121. doi:
Efficacy, durability and safety of KSI-301 antibody biopolymer conjugate in wet AMD – Year 1 primary endpoint results from the pivotal DAZZLE study Open Access
Carl Regillo; Jason S Ehrlich; Daniel Janer; Diana V Do; Pablo Velazquez-Martin; Rezi Zawadzki; Victor Perlroth
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3122. doi:
Real-World Management of Neovascular Age-Related Macular Degeneration in the US Open Access
Andrew A Moshfeghi; Ehsan Rahimy; Nick Boucher; Steven Sherman; Fabiana Q Silva; Hadi Moini; John D Pitcher
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3123. doi:
Phase I/IIa study examining the safety and tolerability of single and multiple rising intravitreal doses of BI 836880 in patients with wAMD Open Access
Oliver Zeitz; Albert Edwards; Allen Hu; Brian Berger; Gudrun Simons; michael ehrlich; Daniel Peter; Sobha Sivaprasad
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3124. doi:
National versus international practice patterns and outcomes of intravitreal anti-VEGF injection for retinopathy of prematurity Open Access
Sandra Hoyek; Nimesh A. Patel; Luis A. Acaba-Berrocal; Kenneth C. Fan; Maria Ana Martinez-Castellanos; Caroline R Baumal; C.Armitage Harper III; Audina M. Berrocal
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3125. doi:
Intravitreal aflibercept compared with laser photocoagulation for infants with retinopathy of prematurity: A FIREFLEYE subgroup analysis Open Access
Andreas Stahl; Emine Sukgen; Wei-Chi Wu; Domenico Lepore; Noriyuki Azuma; Hidehiko Nakanishi; Jan Mazela; Thomas Schmelter; Sergio Leal; Evra Koefuencue
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3126. doi:
Risk Factors for Severe Retinopathy of Prematurity Among Low-risk Infants Open Access
Yvette Schein; Yinxi Yu; Gui-Shuang Ying; Gil Binenbaum
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3127. doi:
Ultra-widefield optical coherence tomography in retinopathy of prematurity Open Access
Susan R Ostmo; Thanh-Tin P. Nguyen; Shuibin Ni; Shanjida Khan; Xiang Wei; Michael F Chiang; Yali Jia; David Huang; Yifan Jian; J. Peter Campbell
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3128. doi:
Effectiveness of an artificial-intelligence based single-exam retinopathy of prematurity prediction model in three Asian populations Open Access
J. Peter Campbell; Aaron S Coyner; Minn Oh; Parag Shah; Praveer Singh; Susan R Ostmo; Nita Valikodath; Emily Cole; Tala Al-Khaled; Sanyam Bajimaya; Sagun KC; Tsengelmaa Chuluunbat; Bayalag Munkhuu; R.V. Paul Chan; Michael F Chiang; Jayashree Kalpathy-Cramer
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3129. doi:
Integration of multidimensional data from bedside optical coherence tomography imaging for retinopathy of prematurity examination. Open Access
Kai Seely; Shwetha Mangalesh; Vincent Tai; Du Tran-viet; Katrina Winter; Stephanie J Chiu; Christian Viehland; Cynthia A Toth
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3130. doi:
Placental Inflammation Significantly Correlates with Reduced Risk for Retinopathy of Prematurity Open Access
Leah Owen; Charles Zhang; Blair Wood; Lara Carroll; Jessica Comstock; Margaret M DeAngelis
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3131. doi:
Rewiring of the adult midget pathway in a primate model of acute photoreceptor loss. Open Access
Ryutaro Akiba; Shane Boniec; Hirofumi Uyama; Hung-Ya Tu; Sharm Knecht; Takayuki Baba; Masayo Takahashi; Michiko Mandai; Rachel Wong
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3132. doi:
Calcium responses to optogenetic stimulation decay faster in primate retinal ganglion cells after photoreceptor ablation Open Access
Zhengyang Xu; Karteek Kunala; Peter Murphy; Edith Koo; Teresa Puthussery; Juliette E McGregor
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3133. doi:
Restoration of high-sensitivity patterned vision in motion with an engineered light-gated G protein-coupled receptor Open Access
Ehud Isacoff; Amy Holt; Michael Berry; Johannes Broichhagen; John Gerard Flannery
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3134. doi:
Knockout of Nr2e3 protects against photoreceptor degeneration in two mouse models of retinitis pigmentosa Open Access
Alexander Kolesnikov; Daniel Murphy; Joseph Corbo; Vladimir Kefalov
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3135. doi:
Cone function is dependent on rod rescue in a mouse model of Retinitis Pigmentosa gene therapy Open Access
Miranda Scalabrino; Mishek Thapa; Esther Zhang; Lucy Peters; Molly Pluenneke; Jay Nolt; Lindsey Chew; Alapakkam P Sampath; Jeannie Chen; Greg Field
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3136. doi:
Loss of Trpm1, the gene for the ON bipolar cell transduction channel, in 15q13.3 microdeletion syndrome contributes to central behavioral deficits Open Access
Chieko Koike; Tesshu Hori; Keishun Iwao; Shohei Ikuta; Satoko Hattori; Keizo Takao; Tsuyoshi Miyakawa
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3138. doi:
Design of Novel Multi-Cistronic AAV2 Gene Therapy Constructs for the Treatment of Diabetic Macular Edema Open Access
Emily Francesca Warner; Kara Boyd; Michael Whitehead; Peter Stuart Widdowson; Katie Binley; Andrew Osborne
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3470. doi:
Efficacy of CRX gene therapy for treating mouse models of dominant CRX-associated retinopathies and beyond. Open Access
Jerome E Roger; Elodie-Kim Grellier; Sophie Lourdel; Muriel Perron
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3471. doi:
QR-1011 corrects splicing in the Stargardt disease type 1-causing variant ABCA4 c.5461-10T>C Open Access
Melita Kaltak; Petra de Bruijn; Sang-Eun Lee; Davide Piccolo; Kalyan Dulla; Rob WJ Collin; Michael E Cheetham; Gerard Platenburg; Jim Swildens
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3472. doi:
Use of non-viral episomal vectors as a large gene augmentation strategy for USH2A retinopathy Open Access
Maria Toms; Lyes Toualbi; Patrick Almeida; Richard Harbottle; Mariya Moosajee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3473. doi:
A Mutation-Independent CRISPR/Cas9-based ‘Knockout and Replace’ Strategy to Treat Rhodopsin-Associated Autosomal Dominant Retinitis Pigmentosa Open Access
Chi-Hsiu Liu; Pavlina Wolf; Ruhong Dong; Yan Huang; Diana Tabbaa; Eugenio Marco; Brian Duke; Andrea Pinilla; Asha Pant; Racheal D’Souza; Judith Newmark; Georgia Giannoukos; Kate Zhang; Adrian Timmers; Mark Shearman; Mariacarmela Allocca
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3474. doi:
Lipid nanoparticles transfect multiple retinal cell types in the non-human primate. Open Access
Renee Christine Ryals; Milan Gautam; Jonathan Stoddard; Rene Reynaga; Scott Shubert; Lauren Renner; Jeonghwan Kim; Wayne Tschetter; Ian Fries; Andreas Lauer; Martha Neuringer; Gaurav Sahay
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3475. doi:
In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration Open Access
Elliot H Choi; Susie Suh; Andrzej Foik; Henri Olavi Leinonen; Gregory Newby; Samagya Banskota; Thanh V Hoang; Samuel W Du; Xin D Gao; Zhiqian Dong; Aditya Raguram; Sajeev Kohil; Seth Blackshaw; David Lyon; David R Liu; Krzysztof Palczewski
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3476. doi:
Targeted deletion of interferon regulatory factor 5 gene in mice triggers choroidal neovascularization Open Access
Congxiao Zhang; Russell Quinn; Eric Nguyen; Nilisha Fernando; Joys Annika G David; Kapil Bharti
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3477. doi:
Characterisation of three novel animal models of geographic atrophy Open Access
Natalie Hudson; Jeffrey O'Callaghan; Conor Delaney; Avril Reddy; Kieva Byrne; Sarah Doyle; Matthew Campbell
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3478. doi:
Spontaneous Polygenetic AMD Preclinical Models Selected from the BXD Family of Mice Open Access
Monica M Jablonski; Xiangdi Wang; Raven N. Simpson; Anand Swaroop; Emily Y Chew; David Ashbrook; Robert W. Williams; TJ Hollingsworth
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3479. doi:
A porcine model of advanced age-related macular degeneration Open Access
Raymond Iezzi; Jarel Gandhi; Alan D Marmorstein
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3480. doi:
Sex and Age-Related Changes in RPE Morphology and Function in Mice Open Access
Margarete Karg; Emma Hoffmann; Drenushe Krasniqi; Daisy Y Shu; May Moorefield; Hannah Philipose; Bruce Ksander; Magali Saint-Geniez
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3481. doi:
Effects of Long Duration of High-Fat Diet on Gut Microbiota Composition and Laser-Induced Choroidal Neovascularization Open Access
Urooba Nadeem; Hugo Adrian Barba; Bingqing Xie; Jason Zhang; Mark D'Souza; Jason Xiao; Michael Boachie-Mensah; Edward F Xie; Eugene Chang; Dinanath Sulakhe; Dimitra Skondra
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3482. doi:
Cell-specific Studies Through Novel Mouse Model Reveal the Transcriptomic Response of Retinal Müller Glia to Aging Open Access
Ana J Chucair-Elliott; Sarah Ocañas; Kevin Pham; Michael Van Der Veldt; Ashley Cheyney; David Stanford; Michael H Elliott; Willard Freeman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3483. doi:
A Novel Suture Device for Anterior Segment Applications Open Access
Caleb Shumway; Jorge Andrade; Douglas Buxton; Nathaniel Nataneli; Martin Mayers; Matthew Wade
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3485. doi:
Combined Umbilical cord patching with amniotic membrane graft for corneal reconstruction Open Access
karim Elmowafi; Rania kamel; Sahar El Tarshoby
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3486. doi:
Laser-assisted Bowman layer graft preparation Open Access
Esther Groeneveld-van Beek; Jacky de Leeuw; Isabel Dapena; Silke Oellerich; Jacqueline van der Wees; Gerrit RJ Melles; Viridiana Kocaba
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3487. doi:
The DMEK Learning Curve in Three Fellows Open Access
Jessica Chen; Alex Bauer; Alyssa Snyder; Michael Straiko; Mark Terry
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3488. doi:
Size and shape matters: Evaluation of endothelial cell viability for preloaded Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) grafts in two different carriers Open Access
Mark S. Ellison; Philip K. Dye; Dolkar T. Tsering; Rebecca Hubbs; Matthew T. Hikes; Kelly Odell; Megan M.W. Straiko; Khoa D. Tran
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3489. doi:
Greater physical activity is associated with neuroretinal thinning in glaucomatous and normative cohorts Open Access
Ella Claire Berry; Henry Marshall; Sean Mullany; Santiago Diaz Torres; Joshua Schmidt; Daniel Thomson; Mark Hassall; Stewart R Lake; Richard A Mills; John Landers; Stuart MacGregor; Robert Casson; Owen Siggs; Jamie E Craig
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3490. doi:
Functional imaging of mitochondria using flavoprotein fluorescence and its correlation with intraocular pressure in treated glaucoma patients Open Access
Julia Anne Kim; Dolly Chang; Sofia De Arrigunaga; Joyce Kang; Sandra Freeman; Yan Zhao; Justin Elstrott; Simon S Gao; Tiffany Heaster; Michael M. Lin; David S Friedman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3491. doi:
Longevity of IOP Control Post Single Bimatoprost Implant Injection in a Phase 3b Study Open Access
Mahdi Basha; James Paauw; Steven R Sarkisian; Miriam Kolko; Ashley Nguyen; Shraddha Mehta; Marina Bejanian; Randy Craven; William Christie
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3492. doi:
Patient Reported Outcome Measures while using a device to objectively measure eye drop adherence Open Access
Steven L Mansberger; Facundo G Sanchez; Jack Phillip Rees; Stuart Keith Gardiner; Viridian Klei; Julie Duvdevany; Max L Kobak; Robert M Kinast
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3493. doi:
An Association between Large Optic Cupping and Total and Regional Brain Volume: The Women’s Health Initiative (WHI) Open Access
Catherine Wang; Sasha Kravets; Abhishek Sethi; Mark A Espeland; Louis Pasquale; Stephen R Rapp; Barbara Klein; Stacy Meuer; Mary N Haan; Pauline M Maki; Joelle Hallak; Thasarat S Vajaranant
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3494. doi:
Pre- and Post-POAG Rate of Visual Field Progression in the Ocular Hypertension Treatment (OHTS) Study Open Access
Mae e Gordon; James David Brandt; Dale K Heuer; Eve J higginbotham; Richard K Parrish II; Chris A Johnson; John L Keltner; Julia Huecker; Michael A Kass
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3495. doi:
Pharmacodynamic response of optic nerve head (ONH) vasculature measured by OCT-angiography (OCTA) after administration of the endothelin receptor antagonist PER-001 Open Access
Brad Fortune; Grant Cull; Crystal Jadach; Kristine Ly; Michaela Dunn; Dawn Jennings; Trinity Holthausen; Howard Lockwood; Stuart Keith Gardiner; Lin Wang; Jennifer Wilk; Juan Reynaud
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3496. doi:
Precise quantification of episcleral venous flow rates in human subjects before and after netarsudil 0.02% Open Access
Sarah Kim; Victoria Chen; Marvin Cruz; Jessica Pottenburgh; Osamah Saeedi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3497. doi:
Early Rate of Optical Coherence Tomography Angiography Changes is Associated with Normal Tension Glaucoma Progression Risk Open Access
Timothy P.H. Lin; Bella Ruyue Shen; Annie Ling; Oscar Wong; Tony Sit; Poemen P Chan; Clement C. Tham; Carol Y. Cheung
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3498. doi:
Comparison Between Swept-Source and Spectral-Domain Optical Coherence Tomography Angiography in Ocular Hypertension and Glaucoma Open Access
Katherine Lun; Bingyao Tan; Chelvin Sng; Leopold Schmetterer; Jacqueline Chua
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3499. doi:
A Novel Image-Based Method to Determine Iris Biomechanics in Angle-Closure Glaucoma Open Access
C Ross Ethier; Mohammad Reza Bahrani Fard; Babak Safa
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3500. doi:
A novel femtomolar hemodynamic modulation strategy reveals major microvascular defects in glaucoma at single-pericyte scale Open Access
Deborah Villafranca-Baughman; Luis Alarcon-Martinez; Jorge Luis Cueva Vargas; Nicolas A Belforte; Florence Dotigny; Adriana Di Polo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3501. doi:
In vivo measurement of plexus-specific retinal erythrocyte velocity and acceleration in human subjects and NHPs Open Access
Shih-En Chen; Victoria Chen; Jessica Pottenburgh; Osamah Saeedi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3502. doi:
Comparison of Cataract Surgery Outcomes in Patients with Type 1 versus Type 2 Diabetes Open Access
Julia L Xia; Jennifer L. Patnaik; Karen L. Christopher
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3503. doi:
Increased Post-Cataract Surgery Refractive Surprise in Glaucoma Patients Open Access
Johnson Huang; Alekya Rajanala; Mai Tsukikawa; Karine D Bojikian; Philip P Chen; Andrew Chen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3504. doi:
Comparison of visual and refractive outcomes in simultaneous vs sequential pars plana vitrectomy and cataract surgery Open Access
Abdelhalim Awidi; Priya Mathews; Yassine Jamil Daoud
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3505. doi:
Zonular instability and decreased capsulorhexis diameter in post-mortem pseudophakic eyes Open Access
Emmanuel Issa Bassam Nassrallah; Georges Nassrallah; Christina Mastromonaco; Ana Beatriz Dias; Jose Joao Mansure; Nabil Saheb; Miguel N Burnier
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3506. doi:
Post-operative inflammation outcomes with the use of a sustained-release intracanalicular dexamethasone implant (Dextenza) following routine phacoemulsification Open Access
Amy Huang; Monica K Ertel; Cristos Ifantides; Jennifer L. Patnaik; Leonard Seibold
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3507. doi:
Inverted meniscus IOLs reduce retinal distortion in the peripheral visual field Open Access
Consuelo Robles; Pedro M Prieto; Jose M. Marin-Sanchez; Encarna Alcon; Pedro Taña; Lucia Hervella; Dimitrios Christaras; Harilaos S Ginis; Pablo Artal
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3508. doi:
MODIFIED SURGICAL IMPLANTATION TECHNIQUE OF SCLERAL-FIXATED ITRAOCULAR CARLEVALE IOL WITH FORMATION OF "SCLERAL POCKETS" Open Access
Lyubomyr Lytvynchuk; Makar Ponomarov; Eric Carlos Reyna; Matus Rehak
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3509. doi:
Capillary velocimetry on human retina---a preliminary study Open Access
Qinqin Zhang; Xiao Zhou; Ruikang K Wang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3510. doi:
Investigation of band 2 in the human outer retina with visible light Optical Coherence Tomography (OCT) Open Access
Vivek Jay Srinivasan; Aaron Kho; Pooja Chauhan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3511. doi:
Balanced-detection visible-light optical coherence tomography in humans at 125 kHz Open Access
Hao Zhang; Ian Rubinoff; David Andrew Miller; Roman Kuranov
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3512. doi:
Automated instrument-tracking and adaptive-sampling for 4D visualization of ophthalmic surgical maneuvers Open Access
Eric Tang; Mohamed El-Haddad; Shriji Patel; Yuankai Tao
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3513. doi:
Automated visualization of Henle's fiber layer and outer nuclear layer in retinal volumes using robotically-aligned optical coherence tomography Open Access
Amit Narawane; Pablo Ortiz; Mark Draelos; Ryan P McNabb; Anthony N Kuo; Joseph A. Izatt
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3514. doi:
Flavoprotein Fluorescence (FPF) Elevation Using Retinal Metabolic Analysis Correlates with Decreased Visual Acuity in Patients with Various Retinal Pathologies Open Access
Sofia Ahsanuddin; Oscar Otero-Marquez; Collin Rich; Richard B Rosen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3515. doi:
Measurement of true Henle’s fiber layer and outer nuclear layer thickness using volumetric directional optical coherence tomography Open Access
Shanjida Khan; Shuibin Ni; Thanh-Tin P. Nguyen; Ringo Ng; Brandon Lujan; Ou Tan; David Huang; Yifan Jian
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3516. doi:
Compensatory expression of Crystallin γS in retinal microglia neutralizes endotoxin-induced neuroinflammation Open Access
Fengyang Lei; Naiwen Cui; Chengxin Zhou; Yamei Cai; Nikolaos Efstathiou; James Chodosh; Demetrios G. Vavvas; Huidan Zhang; David Weitz; Graeme J. Wistow; Eleftherios I Paschalis
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3517. doi:
A Phase 1b/2 Study of the Safety and Tolerability of Tinlarebant in Adolescent STGD1 Subjects Open Access
John R Grigg; Fred Kuanfu Chen; Ta-Ching Chen; Robyn V Jamieson; Nathan L Mata; Webber Liao
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3518. doi:
Systemic Pegylated-Arginase 1 Treatment of db/db mice Attenuates Diabetic Retinopathy Progression Open Access
Katharine Leilani Bunch; Ammar Abdelrahman; Ruth B Caldwell; R. William Caldwell
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3519. doi:
Initial experience with biosimilar bevacizumab-bvzr for intravitreal use in children: A Case Series Open Access
Eric E Jung; Thomas Lee; Aaron Nagiel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3520. doi:
Topical peptide inhibitors of MARCKS reduce signs of dry eye in the alacrimal rat model Open Access
Brian C Gilger; Jacklyn H Salmon; Kenneth B Adler
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3521. doi:
Ocular antibiotics susceptibility of multidrug-resistant Staphylococcus isolated from ocular anterior segment Open Access
Chunmei Wang; Juan Yue; Yueyue Niu; Shoujun Jian; Susu Liu; Hongmin Zhang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3522. doi:
Pharmacological modulation of Toll-like receptor-stimulated downstream inflammatory pathways in an experimental model of uveitis. Open Access
Moksha Laxmi; Nabanita Halder; Atul kumar; Baskar S. Singh; Rohan Chawla; Thirumurthy Velpandian
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3523. doi:
Effect of Statins on the Age of Onset of Age-Related Macular Degeneration Open Access
Durga Ganesh; Jeffrey N. Chiang; Giulia Corradetti; Eran Halperin; Srinivas R Sadda
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3524. doi:
Correlations between Renal Function and Age-Related Macular Degeneration (AMD) Phenotypes Open Access
Amisha Dave; Kristina Hess; Katherine Chen; Henry Wiley; Tiarnan D L Keenan; Elvira Agron; Emily Y Chew; Catherine A Cukras
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3525. doi:
Age-related macular degeneration (AMD), cardiovascular disease and stroke Open Access
Robert Thomson; Joshua Chazaro; Oscar Otero-Marquez; Gerardo Ledesma-Gil; Yuehong Tong; Arielle Coughlin; Zachary R. Teibel; Katy Tai; Harriet Lloyd; Richard B Rosen; Lawrence Yannuzzi; K Bailey Freund; R. Theodore Smith
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3526. doi:
Plasma Metabolites Associated with Optical Coherence Tomography (OCT) Features of Age-related Macular Degeneration (AMD) Open Access
Ines Lains; Xikun Han; Joao Quadrado Gil; Joana Providencia; Archana Nigalye; Rodrigo Alvarez; Vivian Paraskevi Douglas; Rachel S Kelly; John B Miller; Demetrios G. Vavvas; Ivana K Kim; Rufino Silva; Jessica Lasky-Su; Joan W Miller; Deeba Husain
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3527. doi:
Visual acuity results at ten years in participants with age-related macular degeneration enrolled in the Age-Related Eye Disease Study 2 Open Access
Sanjeeb Bhandari; Eleni Konstantinou; Elvira Agron; Traci E Clemons; Emily Y Chew
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3528. doi:
Role of Metformin in the Development and Progression of Age-Related Macular Degeneration Open Access
Jennifer Adeghate; Rikki Enzor; Bushra Usmani; Peter Jones; Jamie Odden; Asad Farooq Durrani; Benjamin Botsford; Steve Koscumb; Oscar Marroquin; Jose Alain Sahel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3529. doi:
Characteristics and outcomes of patients with nAMD managed in US routine clinical practice Open Access
anita barikian; Jaya Badhwar Kumar; April McCullough; Fabiana Q Silva; Steven Sherman; Hadi Moini; Rishi P Singh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3530. doi:
Loss of retinal ganglion cell synaptic outputs to the visual thalamus in the DBA/2J mouse model of glaucoma Open Access
Matthew J Van Hook; Jennifer Thompson; Jennie C Smith
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3531. doi:
Probing the role of retinorecipient target cells in visual circuit regeneration Open Access
Supraja Varadarajan; Onkar Dhande; Phung Le; Andrew Huberman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3532. doi:
Disrupted Macular Cone Post-Synaptic Circuitry is Related to Poor Vision in Albinism Open Access
Uma Balakrishnan; Niamh Wynne; Wanda Pfeifer; Joseph Carroll; Arlene V Drack
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3533. doi:
Electroretinography as a biomarker to monitor Stargardt disease Open Access
Jana Sajovic; Andrej Meglič; Maja Šuštar Habjan; Marko Hawlina; Ana Fakin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3534. doi:
OCT-guided variable-spot ERG enabled spatially resolved measurements to assess retinal function in a selected and integrated region Open Access
Sanghoon Kim; Michael Carlson; Silvia Aparicio-Domingo; Kang Li; Subrata Batabyal; Valeria Canto Soler; Samarendra Mohanty
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3535. doi:
Revival of In Vivo-like ERG A- and B-waves in Ex Vivo Human Organ Donor Eyes Open Access
Anne M Hanneken; Fatima Abbas; Frans Vinberg
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3536. doi:
Correlation between oscillatory potentials and photopic negative response amplitudes in a clinical setting Open Access
Radouil T Tzekov; Sara Safari; Katherine Tsay; Jan J Kremers; Christopher L Passaglia; David Drucker
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3537. doi:
Longitudinal changes in the retinal and choroidal thickness in young children at low and high risk for myopia Open Access
Ashutosh Jnawali; Kristen L Kerber; Fuensanta A Vera-Diaz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3810. doi:
Computational Analysis of Diffusion-Limited Regions in the Choriocapillaris and their Effect on Passive Transfers to the Outer Retina. Open Access
Moussa A. Zouache; Christian A. Klettner
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3811. doi:
Retinal and Choroidal Thickness at Different Eccentricities in the Myopic Eye Open Access
Jose Villa-Carpes; Enrique J. Fernandez; David Orenes; Rosa Martinez-Ojeda; Francisco J. Avila; Jose M. Marin-Sanchez; Juan M Bueno
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3812. doi:
Sector-wise Comparison of Retinal Layer Thickness in High Myopia and Low/Non-Myopia Eyes without Visual Field Defects Open Access
Rachel S Chong; Marco Yu; Yin Ci Sim; Jolene Chia; Amanda Gan; Samantha Lor; Qiu Ying Wong; Shivani Majithia; Seang Mei Saw; Ching Yu Cheng; Donny Hoang; Leopold Schmetterer; Jacqueline Chua
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3813. doi:
Longitudinal thickness changes of peripapillary tissues during high myopia development in juvenile tree shrews Open Access
Mahmoud Tawfik KhalafAllah; Preston A Fuchs; Fred Nugen; Mustapha El Hamdaoui; Alexander levy; Brian C Samuels; Rafael Grytz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3814. doi:
Assessment of stiffness of posterior eye wall in myopic eyes with an ultrasound-based algorithm using strain elastography Open Access
Shen Yi Lim; Kazuyo Ito; Yee Shan Dan; Jason Daryle G. Yu; Ronald H Silverman; Jonathan Mamou; Seang-Mei Saw; Quan V Hoang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3815. doi:
The role of light in the pathogenesis of rhodopsin retinitis pigmentosa Open Access
Rosellina Guarascio; Kwan Hau; Rowan Asfahani; Kalliopi Ziaka; Hannah Poultney; Dimitra Athanasiou; Monica Aguila; Yumei Li; Rui Chen; Michael E Cheetham
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3816. doi:
Deciphering how missense mutations in CRX homeodomain produce distinct dominant retinopathies Open Access
Yiqiao Zheng; CHI SUN; Xiaodong Zhang; Philip A Ruzycki; Shiming Chen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3817. doi:
Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient induced pluripotent stem cells (iPSCs)-derived retinal pigment epithelium (RPE) cells. Open Access
Maria Georgiou; Chunbo Yang; Robert Atkinson; Kuan-Ting Pan; Adriana Buskin; Marina Moya Molina; Joseph Collin; Sebastian E. J. Ludwig; Sushma Nagaraja-Grellscheid; Colin Johnson; Robin Ali; Lyle Armstrong; Viktor Korolchuk; Henning Urlaub; Sina Mozaffari-Jovin; Majlinda Lako
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3818. doi:
Metabolic defects and circadian clock alterations in Prpf31-mutant mice. Open Access
Elora Vanoni; Abdallah Hamieh; Géraldine Puel; Thierry D Leveillard; Emeline F Nandrot
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3819. doi:
Phosphatidylinositol 5-Kinase (PIKfyve) Negatively Regulates Photoreceptor Neuroprotection Open Access
Raju V S Rajala; Mohd A Bhat; Kenneth Teel; Ammaji Rajala
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3820. doi:
Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration Open Access
Amanda M Travis; Samiya Manocha; Jason R Willer; Jillian N Pearring
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3821. doi:
Single-cell transcriptional dynamics and in vivo enhancer assays provide insight into gene regulatory networks of PRDM13 and IRX1 implicated in North Carolina macular dystrophy Open Access
Munevver Burcu Cicekdal; Stijn Van de Sompele; Víctor López-Soriano; Alfredo Dueñas Rey; Miriam Bauwens; Juan J Tena; Kris Vleminckx; Juan R. Martinez-Morales; Elfride De Baere
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3822. doi:
Use of virtual care by Ontario ophthalmologists during the COVID-19 pandemic in 2020 Open Access
Wongel Bogale; Yvonne Buys; Mayilee Canizares; Sherif El-Defrawy; Yaping Jin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3823. doi:
Physician-to-Physician eConsultations to Ophthalmologists at an Academic Medical Center Open Access
Grayson Wilkes Armstrong; Noha A Sherif; Alice Carlyle Lorch
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3824. doi:
Determinants of non-attendance in asynchronous telemedicine ophthalmology clinics Open Access
Ciara O'Byrne; Siegfried Wagner; Laxmi Raja; Robbert Struyven; Mario Cortina-Borja; Pearse Andrew Keane; Josef Huemer; Konstantinos Balaskas; Dawn Sim; Jugnoo Rahi; Ameenat Lola Solebo; Swan Kang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3825. doi:
Comparison of 2-Field and 5-Field Mydriatic Handheld Retinal Imaging in a Community-Based Diabetic Retinopathy Screening Program Open Access
Lizzie Anne Aquino; Recivall Salongcay; Claude Michael Salva; Glenn Paulo Alog; Kaye Locaylocay; Aileen Viguilla Saunar; Jennifer K Sun; Lloyd P Aiello; Tunde Peto; Paolo S Silva
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3826. doi:
Can EHR Data Automatically Calculate Ophthalmic Quality Measures? The Impact of Baselines Open Access
Michelle Hribar; Jimmy S Chen; Aiyin Chen; Michael F Chiang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3827. doi:
Predicting one-day post-cataract surgery intraocular pressure spikes using machine learning methods Open Access
Levi Bonnell; Karen L. Christopher; Naresh Mandava; Anne M. Lynch; Jennifer L. Patnaik
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3828. doi:
Development of Image Recognition Technology to Identify Individuals with Trachomatous Trichiasis Who Need Surgery Open Access
Emily Gower; Juan Carlos Prieto; Hina Shah; Kasey Jones; Rebecca Flueckiger; Jerusha Weaver; Hashiya Kana; Robert Chew
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3829. doi:
Topical Recombinant Human Nerve Growth Factor for Management of Refractory Epithelial Keratopathy Open Access
Xi Dai; Xi Zhu; Sezen Karakus
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3830. doi:
SARM1 protects the cornea from sensory nerve degeneration and persistent severe inflammation in murine Herpes Stromal Keratitis (HSK) Open Access
Hongmin Yun; Kate L Carroll; Anthony St. Leger
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3831. doi:
Inhibitory Effect of Disodium and Lactone Rose Bengal on the Growth of Candida spp. Isolates In Vitro Open Access
Katherine D. Leviste; Heather Durkee; Paula A. Sepulveda Beltran; Braulio C.L.B. Ferreira; Roger M. Leblanc; Eduardo C Alfonso; Guillermo Amescua; Darlene Miller; Jean-Marie Parel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3832. doi:
Metagenomic sequencing of Sjögren syndrome and healthy gut microbiota reveals differential bacterial species that correlate with disease severity Open Access
Laura Schaefer; Firas S Midani; Claudia M Trujillo-Vargas; Stephen C Pflugfelder; Robert A Britton; Cintia S De Paiva
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3833. doi:
Risk Factors Predicting Loss to Follow-Up, Hospital Admission, and Medication Noncompliance Among Patients with Infectious Keratitis at a Public County Hospital Open Access
Jacqueline Breanna Lopez; Lawrence Chan; Murtaza Saifee; Madeline Yung; Matilda F Chan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3834. doi:
Variability of outer retinal hyper-reflective bands detected using optical coherence tomography Open Access
Ayesha Girach; Helen Kuht; Jinu Han; Garima Nishad; Prateek Pani; Yu-Dong Zhang; Zhanhan Tu; Girish Varma; Mervyn Thomas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3835. doi:
Comparison of OCT Eccentric Fixation in Children with Non-residual vs Residual Strabismic Amblyopia Open Access
Jingyun Wang; Sharon Lehman; Dorothy Hendricks; Jing Jin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3836. doi:
Local analysis reveals lower light sensitivity and thicker retinal layers of the amblyopic eyes near the fovea Open Access
Susana T L Chung; Roger Li; Betty Zhu Li; Quan Lei; Dennis M Levi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3837. doi:
Availability of data for cost-effectiveness comparison of vision screening programmes Open Access
Huibert Jan Simonsz; Jan Kik; Eveline Heijnsdijk; Allison Mackey; Gwen Carr; Anna Horwood; Maria Fronius; Jill Carlton; Inger Uhlén
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3838. doi:
Associations between oxygen supplementation and choroid thickness in preterm infants Open Access
Mason Seely; Shwetha Mangalesh; Suzanne Michalak; Neeru Sarin; Vincent Tai; Katrina Winter; Joanne Finkle; Charles Cotten; Yineng Chen; Gui-Shuang Ying; Cynthia Toth; Lejla Vajzovic
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3839. doi:
Single Nuclear RNA Sequencing of Thyroid Eye Disease Retrobulbar Fat Reveals Fibroblasts Undergoing Adipogenesis In Vivo Open Access
Fatemeh Rajaii; Dong Won Kim; Jeong Han; Timothy McCulley; Nicholas Mahoney; Seth Blackshaw
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3840. doi:
Demographic variables and systemic comorbidities associated with diagnosis of chalazion and chalazion incision/excision from a US claims database Open Access
Diana Kim; Brendan McGeehan; Cesar A Briceno; Brian L VanderBeek
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3841. doi:
Antisense oligonucleotide-based rescue of complex splicing defects in ABCA4 Open Access
Zelia Corradi; Laura de Rooij; Rebekkah J Hitti-Malin; Alejandro Garanto; Rob WJ Collin; Frans P Cremers
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3842. doi:
A MiniCEP290 gene replacement therapy to treat CEP290-Leber congenital amaurosis (LCA10) Open Access
Laura Moreno Leon; Wei Zhang; Bhubanananda Sahu; Guangping Gao; Hemant Khanna
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3843. doi:
In vitro modelling of autosomal dominant TGFBI corneal dystrophies and development of a targeted therapeutic approach Open Access
Olivia Farah Rezek; Beatriz Sanchez-Pintado; Michael E Cheetham; Alice E Davidson; Stephen Tuft; Alison J Hardcastle
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3844. doi:
Comparison of CRISPR-Cas13 RNA editing tools for inherited retinal disease Open Access
Lewis E Fry; Michelle E. McClements; Robert E MacLaren
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3845. doi:
AAV5-RPGR (botaretigene sparoparvovec) gene therapy for X-linked retinitis pigmentosa (XLRP) demonstrates localized improvements in static perimetry Open Access
Michel Michaelides; Jialin Xu; Dai Wang; Peggy Wong; Albert Fung; Alexandra Forbes; Stuart Naylor; Robert Zeldin; Maria A Parker; Richard Weleber; Thales Antonio Cabral de Guimaraes; Cagri Besirli; Yesa Yang; James Bainbridge
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3846. doi:
Functional restoration of Kir7.1 nonsense mutations using engineered tRNA Open Access
Bikash R Pattnaik; Meha Kabra; Pawan K Shahi; Enes Akyuz; Christopher Ahern
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3847. doi:
AAV mediated delivery of Exon-specific U1 snRNA corrects ELP1 splicing and prevents retinal degeneration in familial dysautonomia Open Access
Anil Kumar Chekuri; Elisabetta Morini; Emily Kirchner; Jessica Bolduc; Franco Pagani; Luk H. Vandenberghe; Susan Slaugenhaupt
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3848. doi:
Brolucizumab for treatment of diabetic macular edema (DME): 100-week results from the KESTREL and KITE studies Open Access
Charles Clifton Wykoff; Justus G Garweg; Carl Regillo; eric souied; Sebastian Wolf; Dilsher Dhoot; Hansjüergen T Agostini; Andrew Chang; Augustinus Laude; Lidija Kovacic; Lixin Wang; Ying Wang; Emmanuel Bouillaud; David M Brown
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3849. doi:
Efficacy, durability, and safety of faricimab in diabetic macular edema: 2-year results from the phase 3 YOSEMITE and RHINE trials Open Access
Jennifer I Lim; John A Wells; David Aaron Eichenbaum; Carl J Danzig; Kemal Asik; Zdenka Haskova; Shaun Mohan; David Silverman; Yannan Tang; Hugh Lin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3850. doi:
Personalized treatment interval (PTI) dosing dynamics over 2 years in the phase 3 YOSEMITE and RHINE trials of faricimab in diabetic macular edema Open Access
Caroline R Baumal; John Kitchens; Glenn Jaffe; Bianca S Gerendas; Francis Abreu; Kemal Asik; Acner Camino; Nitin Jain; Zdenka Haskova
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3851. doi:
Genetic biomarkers predicting response to anti-vascular endothelial growth factor injections in diabetic macular edema, a pilot study Open Access
Rajya L gurung; Liesel M FitzGerald; Bennet J McComish; ebony lui; Jamie E Craig; Nitin Verma; Alex W Hewitt; Brendan JT Vote; Kathryn P Burdon
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3852. doi:
Automated macular fluid volume as a treatment indicator for diabetic macular edema Open Access
kotaro tsuboi; Qisheng You; Yukun Guo; JIE WANG; Christina J Flaxel; Steven T Bailey; David Huang; Yali Jia; Thomas S Hwang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3853. doi:
Baseline Outer Retinal Layer Thickness is Associated with Response of Diabetic Macular Edema to Anti-VEGF Therapy Open Access
Margalit Mitzner; Ward Fickweiler; Devon Robinson; Tahani Boumenna; Lloyd P Aiello; Jennifer K Sun
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3854. doi:
Discovery of imaging biomarkers for healthy aging and age-related macular degeneration using counterfactual generative adversarial networks Open Access
Martin Joseph Menten; Oliver Leingang; Hrvoje Bogunovic; Robbie Holland; Ahmed M Hagag; Rebecca Kaye; Sophie Riedl; Ghislaine Traber; Lars Fritsche; Toby Prevost; Hendrik P Scholl; Ursula Schmidt-Erfurth; Sobha Sivaprasad; Daniel Rueckert; Andrew J Lotery
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3855. doi:
A deep learning pipeline for the detection and quantification of drusen and reticular pseudodrusen on optical coherence tomography Open Access
Roy Schwartz; Hagar Khalid; Sandra Liakopoulos; Yanling Ouyang; Coen de Vente; Cristina González Gonzalo; Aaron Y Lee; Catherine A Egan; Clara Sánchez; Adnan Tufail
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3856. doi:
Comparison between a deep learning algorithm and human expertise predicting the progression of geographic atrophy (GA) secondary to age-related macular degeneration Open Access
Gregor Sebastian Reiter; Dmitrii Lachinov; Wolf Bühl; Günther Weigert; Christoph Grechenig; Hrvoje Bogunovic; Ursula Schmidt-Erfurth
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3857. doi:
Deep Survival Prediction of Progression from Intermediate to Atrophic AMD from Longitudinal Retinal OCT Open Access
Antoine Rivail; Wolf-Dieter Vogl; Sophie Riedl; Christoph Grechenig; Gregor Sebastian Reiter; Robyn H Guymer; Zhichao Wu; Ursula Schmidt-Erfurth; Hrvoje Bogunovic
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3858. doi:
Feature discovery using ablation studies for deep learning–based geographic atrophy (GA) progression prediction Open Access
Julia Cluceru; Neha Anegondi; Qi Yang; Verena Steffen; Christina Rabe; Michel Friesenhahn; Daniela Ferrara; Simon S Gao
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3859. doi:
Automated Identification of Incomplete and Complete Retinal Epithelial Pigment and Outer Retinal Atrophy Using Machine Learning Open Access
Giulia Corradetti; Jeffrey N. Chiang; Federico Corvi; Muneeswar Gupta nittala; Nadav Rakocz; Akos Rudas; Berkin Durmus; Alec Chiu; Ulzee An; Sriram Sankararaman; Eran Halperin; Srinivas R Sadda
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3860. doi:
The RAP study, Report 6: Quantification of exudative biomarkers in neovascular age-related macular degeneration (nAMD) using deep learning, a type-based comparative analysis. Open Access
Bilal Haj Najeeb; Bianca S Gerendas; Hrvoje Bogunovic; Ursula Schmidt-Erfurth
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3861. doi:
Longitudinal changes in thickness of the aging human lens measured with OCT Open Access
Marco Ruggeri; Yu-Cherng Chang; Iulen Cabeza; Leana Rohman; Bianca Maceo Heilman; Florence Cabot; Sonia H Yoo; Arthur Ho; Jean-Marie Parel; Fabrice Manns
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3862. doi:
Quantification of ciliary muscle movement during accommodation from transscleral OCT images Open Access
Iulen Cabeza; Begoña Calvo; Yu-Cherng Chang; Marco Ruggeri; Fabrice Manns
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3863. doi:
Quantification of ciliary muscle thickness changes during accommodation from dynamic transscleral OCT images Open Access
Ngoc Lan Vy Truong; Gabrielle Monterano Mesquita; Yu-Cherng Chang; Florence Cabot; Marco Ruggeri; Sonia H Yoo; Jean-Marie Parel; Arthur Ho; Fabrice Manns
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3864. doi:
Role of accommodative microfluctuations in deciphering the sign of defocus for blur-driven accommodation Open Access
Praveen Kumar Bandela; Shrikant R Bharadwaj; Arthur Ho; Eric Papas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3865. doi:
Computational evaluation of a novel intraocular lens design for controlling negative peripheral pseudophakic dysphotopsia Open Access
Arthur Ho
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3866. doi:
Quadrifocal diffractive lens design for presbyopia correction Open Access
Jiakai Lyu; Seungpil Bang; Geunyoung Yoon
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3867. doi:
Clinical measurements of peripheral contrast sensitivity in elderly phakic and pseudophakic eyes. Open Access
Aixa Alarcon; Carmen Canovas; Marrie van der Mooren; Priya Janakiraman; Robert Rosen; Linda Lundstrom; Daniel H Chang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3868. doi:
Subretinal fibrosis in patients with choroidal neovascularization based on spectral-domain optical coherence tomography classification: findings from the HARBOR trial Open Access
Sean Adrean; Lauren Hill; Manuel J Amador-Patarroyo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3869. doi:
Use of collagen-hybridizing peptides to assess active fibrosis in 2 mouse models of choroidal neovascularization Open Access
Peter Westenskow; Lucas Bennink; Richard Foxton; Mike Kirkness; Markus Linder
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3870. doi:
Collagen dynamics in one-stage versus two-stage laser-induced choroidal neovascularization using Collagen-1-YFP reporter mice Open Access
Ema Ozaki; Peter Westenskow; Derrick Feenstra; Sarah L Doyle
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3871. doi:
Extracellular vesicles from ARPE-19 cells expressing R345W-Fibulin-3 can induce epithelial-mesenchymal transition in recipient cells via a TGF-beta pathway Open Access
Stephanie Louise Grillo; Mi Zhou; Yuanjun zhao; Sarah Weber; Han Chen; Xiaoming Liu; Hong-Gang Wang; Michael Ford; Matthew Swulius; Alistair J Barber; Jeffrey Sundstrom
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3872. doi:
MiRNA-24 represses TGF-β2 induced epithelial-mesenchymal transition (EMT), endothelial-mesenchymal transition (EndMT), and fibrosis program Open Access
Yinga Wu; Yao Tong; Katherine Byrnes; Qi Zhou; Jing Ma; Shusheng Wang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3873. doi:
Decorin for choroidal neovascularization fibrosis and epithelial-mesenchymal transition of retinal pigment epithelium Open Access
Francine F Behar-Cohen; laura Benichou; Louis Debillon; Karine Bigot; Thierry Bordet; Min Zhao
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3874. doi:
The association of social determinants of health with cataracts in the U.S. Open Access
Muhammad Ali; Abdelhalim Awidi; Jiangxia Wang; Varshini Varadaraj; Cindy Cai; Divya Srikumaran; Pradeep Y Ramulu; Alfred Sommer; Fasika Woreta
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4243. doi:
Final Level of Myopia versus Age of Onset: Effect of Race and Age at Final Refraction Open Access
Mark A Bullimore; Noel A Brennan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4244. doi:
Asian and Western refractive centile curves from meta-analysis of population refraction data Open Access
James Loughman; Kathryn Jill Saunders; Siofra Harrington; Daniel Ian Flitcroft
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4245. doi:
The Prevalence and Risk Indicators of Uncorrected Refractive Error in African Americans: The African American Eye Disease Study (AFEDS) Open Access
Nathan Dhablania; Mina Torres; Kaili Ding; Bruce Burkemper; Roberta McKean-Cowdin; Rohit Varma
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4246. doi:
Myopia control in children wearing DIMS spectacle lens: 6 years results Open Access
Carly SY Lam; Wing Chun Tang; Han Yu Zhang; Dennis Yan-yin Tse; Chi-ho To
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4247. doi:
Identifying Content for an Item Bank to Measure the Quality-of-Life Impact of Myopia Open Access
Ryan Man; Kodi Goh; Ester Lee; Amudha Aranvindhan; Alfred TL Gan; Marcus Ang; Quan V Hoang; Chee Wai Wong; Seang Mei Saw; Eva K Fenwick; Ecosse Luc Lamoureux
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4248. doi:
Open Globe Repairs in the United States 2014-2018: Incidence, risk factors and visual outcomes - An IRIS® Registry (Intelligent Research in Sight) Analysis Open Access
Maurizio Tomaiuolo; Fasika Woreta; Alexander Li; Yoshihiro Yonekawa; James Sharpe; Qiang (Ed) Zhang; Zeba A Syed; Deepak Ramesh; Alice Carlyle Lorch; Nathan Hall; Ankoor Shah; Grant Justin; Leslie Hyman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4249. doi:
The Surprising Impact of Hormones on Keratoconus Open Access
Dimitrios Karamichos; Paulina Escandon; Sarah Nicholas; David Murphy; Lyly Van; Rebecca Cunningham; Kamran Riaz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4250. doi:
High-frequency ultrasound detects biomechanical weakening in keratoconus with a decreasing stiffness at higher grades Open Access
Jun Liu; Sunny Kwok; Xueliang Pan; Andrew Hendershot; William Liu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4251. doi:
Unique structural differences between thin cornea and asymmetric keratoconus quantified using Polarization Sensitive – Optical Coherence Tomography (PS-OCT) Open Access
Rahul P. Patil; Raghav Narasimhan; Yash Patel; Pooja Khamar; Rohit Shetty; Abhijit Sinha Roy
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4252. doi:
Long-Term Follow-Up of Biomechanical Changes in Very Asymmetric Ectasia Open Access
Shizuka Koh; Ryota Inoue; Sayo Maeno; Naoyuki Maeda; Renato Ambrósio; Vishal Jhanji; Kohji Nishida
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4253. doi:
Exosomes and their miRNA/protein profile in keratoconus-affected corneal stromal cells Open Access
Yutao Liu; Mariam Khaled; Theresa Akoto; Dimitrios Karamichos
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4254. doi:
Rescue of Lysyl Oxidase levels by Batimastat and Trehalose treatment in human corneal stromal tissue and cell models: implications for Keratoconus therapy Open Access
NITHIN KIRAN; Rohit Shetty; Pooja Khamar; Arkasubhra Ghosh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4255. doi:
Childhood glaucoma or large optic disc? - The Gutenberg Optic Disc Study (GODS) Open Access
Julia Verena Stingl; Cordula Braun; Felix Wagner; Alexander Schuster; Esther M Hoffmann
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4256. doi:
Short-term changes in Bruch’s Membrane Opening-Based Morphometrics during the first week after trabeculectomy Open Access
Philip Enders; Jan Lüke; Thomas S Dietlein; Alexandra Lappas; Verena Prokosch; Sigrid Roters; Ludwig M Heindl; Claus Cursiefen; Caroline Gietzelt
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4258. doi:
Birefringence of the retinal nerve fiber layer is reduced in early glaucoma eyes analyzed by polarization-sensitive OCT Open Access
Stefan Steiner; Florian Schwarzhans; Sylvia Desissaire; Hemma Resch; Georg Fischer; Michael Pircher; Christoph K Hitzenberger; Clemens Vass
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4259. doi:
A sublamina-based approach to retinal vessel analysis using OCT angiography in glaucoma and glaucoma suspect eyes Open Access
Rolake Alabi; Opeyemi Alabi; Alan W Kong; Mohit Jethi; Luca Della Santina; Yvonne Ou
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4260. doi:
Can the Inner Nuclear Layer Thickness Help Detect Progression in Advanced Glaucoma? Open Access
Eitan Shemuelian; Gadi Wollstein; Maria de los Angeles Ramos Cadena; Zeinab Ghassabi; TingFang Lee; Jiyuan Hu; Hiroshi Ishikawa; Joel S Schuman; Fabio Lavinsky
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4261. doi:
Glaucoma rose plots: redesigning circumpapillary progression analysis Open Access
Timothy Edward Yap; Benjamin Davis; Philip Bloom; Maria Francesca Cordeiro; Eduardo Normando
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4262. doi:
Factors Influencing Reading Speed in Pediatric Vision Impairment Open Access
Dawn K DeCarlo; Anne Caroline Durena; Liyan Gao; MiYoung Kwon
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4263. doi:
Remote and In-Lab Eccentric Viewing Training in Patients with Central Vision Loss Open Access
Brittany Bowman; Jan Skerswetat; Nicole Ross; Peter J Bex
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4264. doi:
Estimating visual acuity without a visual acuity chart Open Access
Yueh-Hsun Wu; Deyue Yu; Judith E Goldstein; MiYoung Kwon; Emily Catherine Watson; Luc Waked; Micaela R Gobeille; Dawn K DeCarlo; Rachel Gage; Chun Wang; Gordon E Legge
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4265. doi:
Longitudinal Results and Test-Retest Variability of a Novel Optokinetic Nystagmus-Based Visual Acuity Test in Children with CLN2 Disease Open Access
Christina Ohnsman; Yevgeniya Atiskova; Jan Wildner; Angela Schulz; Simon Dulz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4266. doi:
Rod and cone dark adaptation in PAX6-associated aniridia Open Access
Hilde Rogeberg Pedersen; J.Gilson Stuart; Erlend Sommer Landsend; Øygunn Aas Utheim; Tor Utheim; Rigmor C Baraas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4267. doi:
Post-hoc simulation study to optimize performance of the computer adaptive EyeQ Open Access
Petra Rausch - Koster; Frank D. Verbraak; Ger M.H.B. van Rens; Ruth M A van Nispen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4268. doi:
Application of Rasch analysis to the TeachCVI survey tool in a spectrum of CVI patients Open Access
Jem Martin; Chris Bradley; Shannin Yee; Nicole Ross
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4269. doi:
Prob-eye-otics: Cytokine Producing Therapeutic Ocular Commensals Open Access
Jackie L Shane; Yannis Rigas; Robert M Q Shanks; Anthony St. Leger
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4270. doi:
Defining the phenotype and distribution of resident immune cells surrounding meibomian gland orifices in mice Open Access
Ching Yi Wu; Laura Elizabeth Downie; Carole Maldonado-codina; Philip Morgan; Holly Rose Chinnery
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4271. doi:
Topical glaucoma therapy is associated with alterations of the ocular surface microbiome Open Access
Chih-Chiun Jamie Chang; Karina Somohano; Christine Zemsky; Anne-Catrin Uhlemann; Jeffrey M Liebmann; George A Cioffi; Lama A Al-Aswad; Susan Lynch; Bryan Winn
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4272. doi:
The Effect of Blocking Substance P in Treating the Allergic Red Eye Open Access
Amirreza Naderi; Shudan Wang; Lingjia Liu; Tomas Blanco; Yutong Xia; Yihe Chen; Reza Dana
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4273. doi:
Topical application of anti-miR-183/96/182 cluster causes transient, reversible corneal nerve reduction and demonstrates therapeutic potential against bacterial keratitis Open Access
Naman Gupta; Sharon A McClellan; Denise Bessert; Linda D Hazlett; Shunbin Xu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4274. doi:
Temporal analysis in Transcriptomic profile identifies immune markers and modulation of key pathways in Murine Model of Multi-Drug Resistant (MDR) Pseudomonas aeruginosa endophthalmitis Open Access
Joveeta Joseph Ruben; POONAM NAIK; Milind Neelkanth Naik
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4275. doi:
Hypoxia adaptation is essential for Aspergillus fumigatus virulence in the cornea Open Access
Kevin K Fuller; Emily Adams; Jorge D Lightfoot
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4276. doi:
Transcription factors involved in determination of photoreceptor fate Open Access
Juan Angueyra; Vincent P. Kunze; Laura K. Patak; Hailey Kim; Katie Kindt; Wei Li
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4277. doi:
Control of selected transcripts in LWS1 vs LWS2 cones by thyroid hormone in zebrafish Open Access
Ashley Alice Farre; CHI SUN; Audrey Duncan; Sam Hunter; Margaret Starostik; Linn Gieser; Milton English; Abirami Santhanam; Eyad Shihabeddin; John O'Brien; Anand Swaroop; Deborah L Stenkamp
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4278. doi:
CCN2 regulates the extracellular matrix and facilitates retinal ganglion cell maturation in the developing retina Open Access
Charles Karrasch; Sohyun Moon; Golam Mohiuddin; Oleg Evgrafov; Brahim Chaqour
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4279. doi:
Transcription factor Myt1L promotes neuronal fate acquisition in the developing retina Open Access
Luciano Custo Greig; Mollie Woodworth; Jeffrey L Goldberg; Sui Wang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4280. doi:
Retina-lens detachment: a matrix-mediated step of vertebrate eye development Open Access
Kristen Kwan; Macaulie Casey; Chase Bryan; J. Thomas Brown
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4281. doi:
Early photoreceptor trajectories towards a cancer-predisposed cone precursor state Open Access
Dominic Shayler; Kevin Stachelek; Sunhye Lee; Yeha Kim; Mitali Singh; Maxwell Bay; Matthew Thornton; Narine Harutyunyan; Andrew Salas; Kayla Stepanian; Jennifer Aparicio; Brendan Grubbs; Michael Bonaguidi; Hardeep Singh; David Cobrinik
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4282. doi:
The role of Tet3 in retinal development and function Open Access
Grazia Giorgio; Silke Haverkamp; Elisa Murenu; Stylianos Michalakis
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4283. doi:
Binding affinity: A measure of potency for OCU200, a potential therapeutic for the treatment of wet-AMD and DME Open Access
Pratap C Naha; Subechhya Neupane; Arun K Upadhyay
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4284. doi:
Aqueous humor vascular endothelial growth factor pharmacodynamics in the phase 3 Archway trial of the Port Delivery System with ranibizumab Open Access
Murtaza Adam; Laura Barras; Mauricio Maia; Shamika Gune; Katie Maass; Michael Chang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4285. doi:
Therapeutic effect of hindered phenol compound in a solid lipid nanoparticle formulation in mouse models of dry AMD Open Access
Yin Shan Eric Ng; Zhenyu Ji; Anthoula Arta; Yu Su; Andrew James Urquhart; Patricia A D'Amore
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4286. doi:
UBX1325, A Novel Senolytic Treatment for Patients with Advanced DME or wet AMD: 24-Week Results of a Phase 1 Study Open Access
Robert Bhisitkul; Sharon Klier; Pamela Tsuruda; Ben Xie; Lauren Masaki; Jessica Bautista; Akbar Khan; Jamie Dananberg
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4287. doi:
Stereopure oligonucleotide treatment results in durable rescue of disease phenotype in a P23H hRHO pig model of human autosomal dominant retinitis pigmentosa (adRP) Open Access
Jennifer M. Noel; Archana Jalligampala; Olivia N Jacobs; Joseph Prestigiacomo; Hailin Yang; Qianli Pan; Fangjun Liu; Yuan Yin; Richard Looby; Chandra Vargeese; Michael Byrne; Maureen A McCall
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4289. doi:
Sex matters in eye and brain metabolism: targeted metabolomics reveals tissue-specific sex difference in metabolism in fasted vs. fed state Open Access
Olivia Roby; Saravanan Meghashr; Rong Xu; Yekai Wang; Jianhai Du
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4290. doi:
Natural history of the progression of choroideremia; 24-month follow-up Open Access
David G Birch; Paul S Bernstein; Ian M MacDonald; Timothy Stout; David Liao; Kirsten Locke; Yi Zhai; Manlong Xu; Mark Lomax; Shobana Aravind; Jennifer Verriotto; David Kirn; Peter Francis
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4291. doi:
Intrinsic signal optoretinography of dark adaptation abnormality due to rod degeneration Open Access
Jie Ding; Tae-Hoon Kim; Xincheng Yao
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4292. doi:
Deep Learning Facilitated Study of the Relationship between Visual Field Sensitivity (VFS) and Photoreceptor Outer Segment (OS) Metrics in Retinitis Pigmentosa (RP) Open Access
Yi-Zhong Wang; Katherine Juroch; Tein Luu; David G Birch
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4293. doi:
Prospective natural history of retinitis pigmentosa due to RHO, PDE6A, or PDE6B mutations: interim analysis of the PHENOROD2 study Open Access
Anne Celle; Alice Le Meur; Daniel C Chung; Saddek Mohand-Said; Jose Alain Sahel; Isabelle S Audo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4294. doi:
ABCA4-alleles bearing two rare cis-variants comprise a significant proportion of those found in affected patients. Open Access
Maria Pilar Martin Gutierrez; Sandra Vermeirsch; Nikolas Pontikos; Mark Simcoe; Michel Michaelides; Gavin Arno; Omar Abdul Rahman Mahroo; Andrew R Webster
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4295. doi:
Vitreoretinal Amyloidosis: Clinical Features, OCTA Appearances, Gene Mutations, and Treatment Outcomes of Vitrectomy Surgery Open Access
Nan Zhou; wenbin wei
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4296. doi:
Photoreceptor Manifestations of Primary Mitochondrial Optic Nerve Disorders Open Access
Yin-Hsi Chang; Yu-Chuan Kang; Pei-Kang Liu; Sarah Levi; Hung-Xuan Wang; Yun-Ju Tseng; Go Hun Seo; Hane Lee; Lung-Kun Yeh; Kuan-Jen Chen; Wei-Chi Wu; Chi-Chun Lai; Laura Liu; Nan-Kai Wang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4297. doi:
The Effect of Physician Face Mask Use on Post-injection Endophthalmitis Open Access
Blake Hugo Fortes; Konstantin Astafurov; Wendy M. Smith; Andrew J. Barkmeier; Timothy W Olsen; Raymond Iezzi; Sophie J. Bakri
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4298. doi:
Clinical Outcomes of Patients with Endophthalmitis after Dexamethasone Intravitreal Implant Open Access
Annika G. Samuelson; Ankur Nahar; Samir N Patel; Raziyeh Mahmoudzadeh; Mirataollah Salabati; JOHN W HINKLE; Rebecca Russ Soares; Ajay E. Kuriyan; Sunir Garg
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4299. doi:
Outcomes of vitreoretinal complications requiring surgery after abusive head trauma Open Access
Yasmin Islam; Syed Gibran Khurshid
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4300. doi:
Recovery of Vision in Open Globe Injury Patients with Initial No Light Perception Vision Open Access
Karen Michelle Wai; Noha A Sherif; Marisa Tieger; Grayson Wilkes Armstrong
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4301. doi:
Risk factors for retinal detachment following open globe injury and outcomes of retinal detachment repair following ocular trauma Open Access
Asad Farooq Durrani; Katie Li; Yunshu Zhou; Avi Toiv; Peter Yu Cheng Zhao; Michael Huvard; David C Musch; David N Zacks
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4302. doi:
The relationship between retinal ganglion cell degeneration and retinal perfusion after acute traumatic brain injury Open Access
Elinor Laws; Jenny Hepschke; Noor Haziq Saliman; Antonio Belli; Richard J Blanch
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4303. doi:
Accommodation Microfluctuation is Impaired in Mild Traumatic Brain Injury Open Access
Nawaf M Almutairi; Chunming Liu; Karen Hampson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4304. doi:
Dorsal and ventral stream associations with autistic traits in children Open Access
Andrew Ernest Silva; Jane E Harding; Chris J.D McKinlay; Darren W.T. Dai; Samson Nivins; Rajesh K Shah; Benjamin Thompson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4305. doi:
Color Correcting Lenses Enhance Cone VEPs in Color Deficiency Open Access
Jeff C Rabin; Frances Silva; Natalie Trevino; Harper Gillentine; Li Liqing; Loary Inclan; Gary Anderson; Erica Lee; Harrison Vo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4306. doi:
Contrast imbalance and its impact on stereoacuity in keratoconus? Open Access
Bhagya Lakshmi Lakshmi Marella; Pravin Krishna Vaddavalli; Jagadesh C Reddy; Miriam Conway; Catherine M Suttle; Shrikant R Bharadwaj
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4307. doi:
Cognitive visual functions among diabetic and healthy individuals with diabetic family history Open Access
Aiswaryah Radhakrishnan; Suchismita Rout
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4308. doi:
Effect of interocular difference in retinal illuminance on monocular and binocular flicker perception Open Access
Reena Durai; Amithavikram R R Hathibelagal; Marisa Rodriguez Carmona; John L Barbur; Shrikant R Bharadwaj
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4309. doi:
Effect of Rapid Alternating and in phase flicker occlusion on Stereopsis Open Access
Bhavatharini Ramakrishnan; Scott B Stevenson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4310. doi:
Vision outcomes of a vision screening program amongst schoolchildren in underserved, rural, Zimba, Zambia Open Access
Joshua Huang; Jordan Huang; Jaxon Huang; Andrea Steeves; Paul Huang; Katherine Huang; Stephen Huang; Brighton Samoyo; William Astle; John Huang; Peter Huang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4242 – A0170. doi:
The aftermath of the COVID-19 pandemic on access to corneal transplant procedures in Morocco Open Access
Safia Benamar; IMANE TARIB; Ihsane Hmamouchi; Mohammed Belmekki
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4241 – A0169. doi:
Early Lifetime Substance Use and Development of Significant Visual Impairment or Blindness: An Analysis of the National Survey on Drug Use and Health Open Access
Asher Khan; Zain S Hussain; Asad Loya; Kaushal Shah; Kamran Riaz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4240 – A0168. doi:
Risk factors for vision loss among nursing home residents: a cross-sectional analysis Open Access
William Monaco; Riaz Qureshi; Hongdao Meng; Areeb Arif; Sulbh Aggarwal
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4238 – A0166. doi:
Monthly certifications of vision impairment in England and Wales in 2020 and 2021 compared with pre-pandemic years Open Access
Omar Abdul Rahman Mahroo; Wen Xing; Snezana Lazarevic; Antra Zekite; Declan Flanagan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4237 – A0165. doi:
Geographic Distribution and Trends of Self-Reported Visual Impairment in 2010-2019 Open Access
Lucy Cobbs; Raziyeh Mahmoudzadeh; Mirataollah Salabati; Jacquelyn Hamati; Rebecca Russ Soares; Yoshihiro Yonekawa
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4236 – A0164. doi:
Nyctalopia Due To Severe Liver Cirrhosis-induced Vitamin A Deficiency: A Case Report Open Access
Shuyi Chen; Amy Quan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4235 – A0163. doi:
Epidemiology of Contact Lens-Related Corneal Disorders in Emergency Room: Data from Nationwide Emergency Department Sample (NEDS) Open Access
Bushra Usmani; Sanjana Dayananda; Syed Mahmood Ali Shah; Vishal Jhanji
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4234 – A0162. doi:
Visual function outcome measures of a comparative trial of low vision enhancement head-mounted display systems (HMD) Open Access
Ashley Deemer; Rob Chun; Chris Bradley; Kyoko Fujiwara; James Deremeik; Micaela R Gobeille; Frank Werblin; Robert W Massof
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4232 – A0160. doi:
Visual hallucinations caused by Charles Bonnet Syndrome are not impacted by the psychosocial factors resulting from COVID-19 restrictions Open Access
Aysha N Kinakool; Stefania S Moro; Jennifer Kate Evelyn Steeves
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4229 – A0157. doi:
Test-Retest Reliability of the novel Quantitative Contrast Sensitivity Function Test Open Access
Paul Zhou; Filippos Vingopoulos; Augustine Bannerman; Zakariyya Hassan; Nimesh A. Patel; David M. Wu; John B Miller
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4228 – A0156. doi:
Canadian patient experience with age-related macular degeneration Open Access
Larissa Moniz; Chad Andrews; Jennifer Pereira
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4226 – A0154. doi:
Using scalar blur analyses to examine the effect of test criteria on performance of vision screening tests Open Access
Bright Anyimah Oduro; Andrew J Logan; Joanne M Wood; Scott Read; Niall Strang; Gunter Loffler; Shelley Hopkins; Rebecca Cox; Gael E Gordon; Graeme Kennedy
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4225 – A0153. doi:
Associations between clinical measures and quality of life in refractive error Open Access
Mallika Prem Senthil; Ranjay Chakraborty
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4223 – A0151. doi:
Impact of Glare Strength on Contrast Sensitivity in Pseudophakes Open Access
Katherine Lee; Cameron Sefton
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4221 – A0149. doi:
The impact of season and sunlight on depression in adults with visual impairment Open Access
Rob van der Linden; Hilde Petronella Adriana van der Aa; Ruth M A van Nispen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4220 – A0148. doi:
Evaluation of measurement properties of an online nurse-assisted eye-screening tool for home healthcare patients Open Access
Ruth M A van Nispen; Ellen Elsman; Olivia Lee; Robert Wisse; Jan Keunen; Ger van Rens; Hilde Petronella Adriana van der Aa
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4219 – A0147. doi:
Letter Contrast Sensitivity Validation Open Access
Michel Guillon; Pasquale Pepe; Jessie Hull; Rajaraman Suryakumar
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4218 – A0146. doi:
MOSAIC: A qualitative study of the clinical, humanistic, and financial burden of geographic atrophy (GA) among patients Open Access
Daniel Jones; Jared Nielsen; Danielle Altman; Julia Carpenter-Conlin; Beverly Lui; Patrick Marquis; Alissa Rams; Renaud Desgraz; Teya Lovell; Sujata Sarda; Winfried M K Amoaku
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4217 – A0145. doi:
The Effect of Ophthalmic Blue Blocker Lenses and Anti-Reflective Coats on Digital Reading Efficiency and Comfort Open Access
Christina Wentz; Janis Winters
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4216 – A0144. doi:
Visual Wayfinding in people with Ultra Low Vision using Virtual Reality Open Access
Arathy Kartha; Roksana Sadeghi; Thom Swanson; Gislin Dagnelie
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4215 – A0143. doi:
Health Related Quality of Life in Patients with Uveitis and Sarcoidosis Open Access
Mark Andrew Solinski; Emily Wong; Samuel Shing; Samantha Swamy; Veena R Raiji
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4214 – A0142. doi:
The clinical applications of anti-microRNA-328 therapy in myopia control and dry eye disease Open Access
Suh-Hang Hank Juo; Chun-Ling Liang; Jiunn-Liang Chen; Wei-Yu lai
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4213 – A0141. doi:
Prevalence of Obesity in Adolescents with Amblyopia Open Access
Carolyn Drews-Botsch; Kyle Machicado; Scott R Lambert; Ali Weinstein
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4212 – A0140. doi:
Hand Grip Strength and its Ocular Associations: The Ural Eye and Medical Study Open Access
Songhomitra Panda-Jonas; Jost Jonas; Gyulli Kazakbaeva; Ellina Iakupova; Mukharram Bikbov
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4210 – A0138. doi:
Association of Vision and Hearing Impairment with Depression, Anxiety and Suicidal Ideas in Populations of Russia: The Ural Eye and Medical Study and the Ural Very Old Study Open Access
Gyulli Kazakbaeva; Mukharram Bikbov; Ellina Iakupova; Songhomitra Panda-Jonas; Jost Jonas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4209 – A0137. doi:
Effect of scheduled breaks on Digital Eye Strain Open Access
Mark Rosenfield; Sophia Johnson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4208 – A0136. doi:
The Level of Eye Care among Eyecare Professionals Themselves Open Access
Emily G Sherry; Leen S Azeez; Daniel Mojica; Ahmad Kheirkhah
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4207 – A0135. doi:
Evaluation of refractive error in a geographically isolated population may reveal unique risk factors associated with visual disability Open Access
John Lillvis; Charles Zhang; Leah Owen; Tamim Shaikh; Margaret M DeAngelis
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4206 – A0134. doi:
Patient Experience with Anti-VEGF Intravitreal Injections in Neovascular Age-related Macular Degeneration and Diabetic Macular Edema: A Multinational Observational Study Open Access
Veeral Sheth; Tunde Peto; Jérémy Lambert; Hannah Lewis; Valentin Barbier; Brittany Gentile; Mirela Mirt; Gloria Chi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4205 – A0133. doi:
Retinopathy of Prematurity: 5 years and 715 patients, an Epidemiological Analysis Open Access
Yuvitxa Geraldine Justiniano-Becerra; Felipe Ramirez-Solis; Kouatzin Aguilar-Morales; Marlon Garcia-Roa; Veronica Romero-Morales; Jose Fernando Perez-Perez; Miguel Vazquez; Paulina Ramirez-Neria; Yolanda Villalpando-Gomez
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4201 – F0261. doi:
VCAM1 regulates Fra1/JunB mediated IL-8 expression and pathological retinal neovascularization in a murine model of oxygen-induced retinopathy Open Access
Geetika Kaur; Shivantika Bisen; Deepti Sharma; Nikhlesh K. Singh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4199 – F0259. doi:
Re-treatments after laser coagulation or anti-VEGF injections in infants treated for retinopathy of prematurity – data from the German ROP registry Open Access
Johanna Madeleine Pfeil; Teresa Barth; Wolf Lagrèze; Birgit Lorenz; Karsten Hufendiek; Raffael Liegl; Helge Breuss; Sebastian Bemme; Jakob Ferdinand Meyer; Barbara Glitz; Daniela Suesskind; Ameli Gabel-Pfisterer; Christos Skevas; Tim U Krohne; Vinodh Kakkassery; Andreas Stahl
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4198 – F0258. doi:
Risk Factors for Persistent Avascular Retina Following Bevacizumab Therapy for Retinopathy of Prematurity Open Access
Hailey Kay Robles-Holmes; J. Peter Campbell; Eric Nudleman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4197 – F0257. doi:
Characteristics of babies with unstable clinical course screened for retinopathy of prematurity Open Access
Jennifer Patnaik; Jenae Stutzman; Anne M. Lynch; Emily McCourt
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4196 – F0256. doi:
Refractive outcomes after primary bevacizumab followed by laser versus primary laser alone for Retinopathy of Prematurity Open Access
Alyssa Spiller; Lana Verkuil; Brian Forbes; Yinxi Yu; Gui-Shuang Ying; Gil Binenbaum
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4194 – F0254. doi:
Development of Anisometropic Amblyopia in Children treated for Type I Retinopathy of Prematurity Open Access
Emily K Wiecek; James Akula; Deborah Vanderveen; Iason Mantagos; Carolyn Wu; Amber-Lee Curran; Anne B Fulton
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4193 – F0253. doi:
Use of Serial Anti-VEGF Injections in Patients with Severe Retinopathy of Prematurity Open Access
Bradley Gundlach; Tessa Gillespie; Jason Clark Strawbridge; Monica Khitri; Alison Chu; Irena Tsui
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4189 – F0249. doi:
Maternal sociodemographic risk factors for retinopathy of prematurity Open Access
Jason Clark Strawbridge; Carla Janzen; Alison Chu; Irena Tsui
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4188 – F0248. doi:
The Effectiveness of Telemedicine Screening for Retinopathy of Prematurity in the Remote Midwest United States Open Access
Alexander W Suh; Joseph Martin; Katherine Wang; Donny Suh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4187 – F0247. doi:
Clinical outcomes of infants with type 2 and low grade retinopathy of prematurity after discharge from the neonatal intensive care unit Open Access
Jenae Stutzman; Cheryl Fonteh; Anne M. Lynch; Emily McCourt; Marc Mathias
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4186 – F0246. doi:
Light-Adapted Electroretinographic (ERG) Responses to Full-Field Stimuli in Children Treated for Retinopathy of Prematurity (ROP) Open Access
Amber-Lee Curran; Deborah Vanderveen; Iason Mantagos; Carolyn Wu; James D Akula; Anne B Fulton
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4185 – F0245. doi:
Outcomes of infants with retinopathy of prematurity treated with intravitreal bevacizumab with or without laser ablation Open Access
Hank Patrick; Yu-Guang He; Angeline Wang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4184 – F0244. doi:
Relationship of Multifocal Electroretinographic Responses and Macular Layer Volume in Eyes Treated for Retinopathy of Prematurity Open Access
Bilal K AlWattar; Jagvi K Patel; Mariana I Fonseca; Alexandra Nouck-a-Nwal; Pablo Altschwager; Anne B Fulton; James D Akula
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4180 – F0240. doi:
Maternal diabetes, particularly Type 2 diabetes, is associated with increased odds of Stage 3-5 retinopathy of prematurity. Open Access
Dolly Ann Padovani-Claudio; Alexa Love; Adam Lewis; Lisa Bastarache; Jennifer Sucre; Sara Van Driest
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4178 – F0238. doi:
Structural and functional ophthalmological follow-up of a preterm population: report at six years of age Open Access
Domenico Lepore; Benedetta Caproli; Lorenzo Orazi; giulia Amorelli; Francesca Gallini; Daniela Ricci; Lorenzo Hu; Federico Giannuzzi; Maria Petrianni; Filippo Amore; Giovanni Vento
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4177 – F0237. doi:
Epidemiology of Retinopathy of Prematurity in the United States from 2003 to 2016 Open Access
Henry Skrehot; Anshul Bhatnagar; Amit Bhatt; Honey Herce; Christina Y Weng
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4174 – F0234. doi:
Trends in retinopathy of prematurity training and future practice intentions among retina and pediatric ophthalmology fellows Open Access
Emily Eton; Benjamin Young; Cagri G Besirli
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4173 – F0233. doi:
Pilot Study of Retinal Vessel Outgrowth Following Conventional Versus Low-Dose Bevacizumab for Retinopathy of Prematurity Open Access
David Sutter; Talita Toledo Lima; Noreen Clarke; Kathleen Anulao; Thomas Lee; Aaron Nagiel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4172 – F0232. doi:
Quality Improvement of Retinopathy of Prematurity Care in the Department of Defense Universal Healthcare System: Epidemiology, Follow-up, and Early Childhood Visual Sequelae Open Access
Grant Justin; Anthony Cox; Lisa Peterson; Marcus Colyer; Gregory Gorman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4171 – F0231. doi:
Physiologically Based Dissolution Modeling for Topical Ophthalmic Suspensions Open Access
Clifford Jin; Hovhannes John Gukasyan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4170 – F0162. doi:
Targeting, Compartmentalization and Durability of Suprachoroidally Injected Small Molecule Suspensions in Multiple Preclinical Models Open Access
Viral Kansara; Leroy Muya; Cherry Wan; Shelley Hancock; Thomas A Ciulla
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4168 – F0160. doi:
A comparative pharmacokinetics study of 3 Latanoprost eyedrops solutions containing various excipients in an animal model Open Access
Hayette Rebika; Laure Chauchat; Thierry Amar; Karen Viaud-Quentric; Camille Guerin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4166 – F0158. doi:
In vitro permeation of Latanoprost eyedrops in a 3D human corneal tissue model Open Access
Camille Guerin; Laure Chauchat; Hayette Rebika; Yulia Kaluzhny; Martine Claret
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4165 – F0157. doi:
Nanoparticles made of pseudoproteins penetrate into mouse eyes Open Access
Peter Heiduschka; Wenliang Zhang; Temur Kantaria; Tengiz Kantaria; Ramaz Katsarava; Nicole Eter
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4163 – F0155. doi:
Terminable cell-encapsulating collagen-alginate composite device for sustained intraocular delivery as a therapy for retinal degenerative diseases Open Access
Tingyu Hu; Brian K.C. Tam; Yau Kei Chan; Wai-Ching Lam; Amy CY Lo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4162 – F0154. doi:
In Vitro and In Vivo Characterizations of GB-401, A Sustained Release Intravitreal Implant Containing A Beta-Adrenergic Antagonist Prodrug for Primary Open Angle Glaucoma (POAG) Open Access
Yun Yu; Jane Chisholm; David McKenzie; Daniel Lucena Domingues; Delia Cardona; Ting-Wei Young; Qingyun Lu; Ming Yang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4159 – F0151. doi:
Assistance for macular degeneration (MD): Different strategies for different augmentations Open Access
Alexandra Sipatchin; Miguel García García; Siegfried Wahl
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 714 – F0442. doi:
One-Year Outcome of Ocular Injuries in Survivors of the Beirut Port Ammonium Nitrate Blast Open Access
Malik Said Ladki; Ahmad Mansour; Daniel Cherfan; Alex Jalkh; Ferenc Kuhn
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 696 – F0221. doi:
Evidence-Based Screening to Optimize the Yield of Positive Ophthalmologic Examinations in Children Evaluated for Non-accidental Trauma Open Access
Maxwell Su; Kirby Taylor; Jaquelin Stoutin; Courtney Shaver; Matthew Recko
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 694 – F0219. doi:
Computational Modeling of Soccer Ball Trauma of the Eye and Comparison With Abusive Head Trauma Open Access
Matthew Lam; Pengfei Dong; Yasin Shokrollahi; Donny W Suh; Linxia Gu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 692 – F0217. doi:
Rates of Structural and Functional Progression of Glaucoma and Their Risk Factors in an African Ancestry Cohort Open Access
Rebecca Salowe; Yineng Chen; Selam Zenebe-Gete; Roy Lee; Harini V Gudiseva; Qi N Cui; Eydie G Miller-Ellis; Victoria Addis; Prithvi Sankar; Ebenezer Daniel; Gui-Shuang Ying; Joan O'Brien
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 625 – A0365. doi:
Prevalence of Refractive Error in Inherited Retinal Dystrophies Open Access
Shaden Yassin; Evan Walker; Shyamanga Borooah
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 619 – A0334. doi:
Diabetic Retinopathy Screening Experiences among Hispanic, Spanish-Speaking Adults: “¡Trátame Como Familia!” Open Access
Pamela Capellan; Eugenia Greig; Kristen Harris Nwanyanwu; Rosana Gonzalez-Colaso
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 558 – A0123. doi:
Association between heavy metals and diabetic retinopathy in the National Health and Nutrition Examination Surveys (NHANES) Open Access
Anne Xuan-Lan Nguyen; Leonardo Landó; Xuan-Vi Trinh; Jerry Kurian; Vincent Quoc-Huy Trinh; Albert Y. Wu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 556 – A0121. doi:
Intriguing linear semi-logarithmic relationships of oxygen permeability with water, silicon, and fluorine contents of silicone-hydrogel contact lens materials Open Access
Terin E Dupre; William J Benjamin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 527 – A0225. doi:
Dynamic Salt Accumulation in the Post-Lens Tear Film with Soft-Contact-Lens Wear: Implications for Protection Against Corneal Hyperosmolarity Open Access
Clayton J Radke; Young Hyun Kim; Thien Nguyen; Meng C Lin; CHENG-CHUN PENG
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 519 – A0217. doi:
Choroidal Abnormalities in Pediatric NF1: a Cohort Natural History Study Open Access
Raffaele Parrozzani; Luisa Frizziero; Giacomo Miglionico; Chiara Sofia De Biasi; Giulia Midena; Edoardo Midena
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 482 – A0019. doi:
Role of Warburg Effect in Age-Related Macular Degeneration Open Access
Amany M Tawfik; Yara A Samra; Pragya Rajpurohit; Wagdy Elkalawozgy; Yusra Zaidi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 465 – A0002. doi:
Comparison of stimulus types for retinotopic cortical mapping of macular disease Open Access
Maximilian Pawloff; David Linhardt; allan hummer; Ursula Schmidt-Erfurth; Christian Windischberger; Markus Ritter
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4543 – F0457. doi:
Visual acuity and full-field stimulus thresholds (FST) over 2 years in the RUSH2A study: annual rates of change from mixed effects modeling Open Access
Peiyao Cheng; David G Birch; Jacque L Duncan; Frederick L Ferris; Maureen G Maguire; Allison R. Ayala; Janet K Cheetham; Todd Durham; Abigail T Fahim; Rachel M Huckfeldt; Michel Michaelides; Mark E Pennesi; Jose Alain Sahel; Katarina Stingl; Ajoy Vincent; Christina Y Weng
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4480 – F0267. doi:
Localised cone density and retinal sensitivity changes in female carriers of RPGR mutations Open Access
Danial Roshandel; Tina M. Lamey; Jason Charng; Rachael C Heath Jeffery; Terri L. McLaren; Jennifer A. Thompson; John N. De Roach; Samuel McLenachan; David A. Mackey; Fred Kuanfu Chen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4478 – F0265. doi:
Semi-Automated Blood Velocity Determination Using Adaptive Optics Scanning Laser Ophthalmoscopy XT Images Open Access
Jonathan Huang; Nicholas Konopek; Jessica Moonjely; Amani A Fawzi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4441 – F0120. doi:
Non-invasive assessment of retinal structure in the elderly 13-lined ground squirrel Open Access
Hannah M Follett; Ching Tzu Yu; Owen Bowie; Chloe Guillaume; Dana Merriman; Phyllis Summerfelt; Joseph Carroll
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4416 – F0095. doi:
A model system to define injection pressure and flow characteristics during subretinal drug delivery Open Access
Reza Ladha; Benjamin Merveille; Roland Wyns; Thijs Meenink; François Willermain; Marc D De Smet
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4412 – F0091. doi:
The Efficacy of Netarsudil - Post-approval Reality Open Access
Oluwafeyikemi Okome; Jane Song; Jun Lin; Sze Wong
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4379 – A0422. doi:
Factors affecting eye preference in a prospective randomized controlled fellow eye study comparing WFG-LASIK and WFO-LASIK treatment Open Access
Bryce Chiang; Edward E Manche
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4362 – A0299. doi:
Evaluation of tensile strength and burst pressure of slipknots and surgeon’s knots Open Access
Patrick Wang; Davin Johnson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4337 – A0274. doi:
Later bedtime associated with greater myopic refractive error and variations in axial length rhythms Open Access
Xiao Nicole Liu; Thomas John Naduvilath; Padmaja Sankaridurg
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4328 – A0033. doi:
Wide field topographical choroidal thickness measurement following binocular, eye-tracking mapped, short-term optical defocus Open Access
Peter Wagner; Arthur Ho; Juno Kim
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4319 – A0024. doi:
Choroidal thickness changes in response to defocus-free monochromatic light Open Access
Katharina Breher; Diana Gottschalk; Siegfried Wahl
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4318 – A0023. doi:
Accommodation-induced changes in ciliary body length and thickness, peripheral choroidal thickness and peripheral axial length Open Access
David Andrew Atchison; Dinesh Kaphle; Marwan Suheimat; Katrina L Schmid
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4314 – A0019. doi:
At-Home Refraction Measurement Open Access
Noam Sapiens; Amra Ramic; John Serri
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4204 – A0132. doi:
Pulmonary function in school-age children following intravitreal injection of bevacizumab for retinopathy of prematurity Open Access
Wei-Chi Wu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4203 – F0263. doi:
Thermal conduction in posterior scleritis and choroiditis. Open Access
Ankush Kawali; Aayesha Khanum; Apeksha Shettigar; Ashwin Mohan; Srinivasan Sanjay; Jananee Rajendran; Padmamalini Mahendradas; Rohit Shetty
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4097 – F0061. doi:
Retinal Mitochondrial Flavoprotein Fluorescence in Patients with Genetically Confirmed Retinal Dystrophies Open Access
Matthew Russell; Justin Muste; Collin Rich; Kurt Riegger; Rishi P Singh; Elias I Traboulsi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4094 – F0058. doi:
Depolarization mapping in the retina using polarization-sensitive OCT in a large field of view Open Access
Alice Regina Motschi; Sylvia Desissaire; Markus Schranz; Stefan Steiner; Florian Schwarzhans; Hrvoje Bogunovic; Philipp Ken Roberts; Clemens Vass; Michael Pircher; Christoph K Hitzenberger
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4071 – F0035. doi:
Characterization of the human iridocorneal angle in vivo using OCT Gonioscopy Open Access
Alessandra Carmichael-Martins; Brett King; Thomas J Gast; Brittany Walker; Stephen A Burns
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 402 – F0440. doi:
Acute Ophthalmic Manifestations in Mycoplasma Induced Rash and Mucositis Open Access
Abdelrahman M. Elhusseiny; Ramy Rashad; Swapna S Shanbhag; James Chodosh; Hajirah N. Saeed
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3946 – A0226. doi:
Optical Coherence Tomography Navigated Laser Retinopexy for Retinal Breaks Open Access
Simon Salzmann; Christian Burri; Sami Al-Nawaiseh; Philip Wakili; Christoph Meier
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3793 – F0214. doi:
Treatment of drusen in dry age-related macular degeneration with photobiomodulation : single-center study Open Access
Manal Benlahbib; Carl Joe Mehanna; Hoang Mai Le; Eric Souied
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 374 – F0205. doi:
Higher rates of strabismus surgery and residual amblyopia in children with Medicaid using the IRIS Registry Open Access
Marian S. Blazes; Megan Lacy; Aaron Y Lee; Cecilia S Lee; Kristina Tarczy-Hornoch
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3659 – A0316. doi:
Long-term visual acuity outcomes of fovea-involving rhegmatogenous retinal detachments following pars plana vitrectomy (PPV) or combined PPV/scleral buckle surgery Open Access
Caroline Awh; Karina E. Pedersen; Joseph Abraham; Rishi P Singh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3469 – F0369. doi:
Racial disparities in retinal detachment presentation and postoperative outcomes Open Access
Pooja Manesh Shah; Scott Vadala; Effie Rahman; Margaret Ashley Greven
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3428 – F0328. doi:
Social Media Evaluation of Seasonal and Geographic Trends of Corneal Ulcers in the United States Open Access
Jamie H Choi; Erin Ong; Wuqaas Munir
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3238 – A0273. doi:
The challenge of treating the severest forms of chronic non-infectious posterior and panuveitis Open Access
Christoph Spartalis; Nicole Stübiger; Martin Spitzer; Udo Bartsch; Yevgeniya Atiskova
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3203 – A0429. doi:
Atherosclerotic disease and serum risk factors in phenotypes of age-related macular degeneration (AMD) Open Access
Arielle Coughlin; Robert J. Thomson; Joshua Chazaro; Jason Jo; Oscar Otero-Marquez; Gerardo Ledesma-Gil; Yuehong Tong; Zachary R. Teibel; Katy Tai; Harriet Lloyd; Richard B Rosen; Lawrence Yannuzzi; K Bailey Freund; R. Theodore Smith
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 316 – F0147. doi:
A Hierarchical Bayesian Change Points Method to Study the Long-Term Natural History of Diseases Open Access
Liangbo Linus Shen; Lucian V Del Priore; Joshua Warren
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 315 – F0146. doi:
Determining the Ocular Biocompatibility of a Novel VEGF-A and Ang-2 Bispecific Protein (RO-634) Through Histological Analysis Open Access
Evan Sembell; Jeffrey L Olson; Anthony Jones; Josh Morgenstern; Anne Strong; Steven Droho; Niklaus Mueller; Michael Huvard; Shaun Bevers; Li Xu; Peter K Kaiser; Arshad M. Khanani; Jeffrey S Heier; Nikhil Gupta; John M Kunzeman; Ramanath Bhandari
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 305 – F0108. doi:
Detecting patients with ocular comorbidities when screening for diabetic retinopathy (DR): an out-of-distribution (OOD) perspective Open Access
Jelena Novosel; Jian Dai; Daniela Ferrara; Fethallah Benmansour
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2987 – F0257. doi:
Predicting optimal treatment regimen for patients with neovascular age-related macular degeneration (nAMD) using machine learning Open Access
Yusuke Kikuchi; Ales Neubert; Jian Dai; Carlos Quezada Ruiz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2986 – F0256. doi:
Sequential OCTA scans have greater signal variability around venules. Open Access
Nimesh Bhikhu Patel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2959 – F0113. doi:
Comparing FA and OCTA evaluation of retinal vascularity of murine eyes with diabetic retinopathy with Contrast-Limited Adaptive Histogram Equalization (CLAHE) and Matched Filter Image Pro... Open Access
Christopher Loh; Pengfei Zhang; Ratheesh K. Meleppat; Oscar Ramos-Soto; Sandra E. Balderas-Mata; Robert J Zawadzki; Susanna S Park
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2958 – F0112. doi:
Evaluating different thresholding methods for vessel density calculations in optical coherence tomography angiography scans of diabetic macular edema eyes Open Access
Bonnie Bertha Huang; Janice Xin-Yee Ong; Amani A Fawzi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2957 – F0110. doi:
Age-related assessment of choroidal angio-architecture over the macular region in healthy eyes using swept-source optical coherence tomography angiography. Open Access
Aditya Verma; Kowsigan Magesan; Maanasi Mahalingam; Srinivas R Sadda; Giulia Corradetti; Ahmed Roshdy Alagorie; Amose T; Ramya Gnanaraj; Parveen Sen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2956 – F0109. doi:
Repeatability of swept-source optical coherence tomography angiography (SS-OCTA) metrics in healthy and glaucomatous eyes Open Access
Niranchana Manivannan; Gary C Lee; Thomas Callan; Birgit Sandhoefner; Kyung Rim Sung; Gala Beykin; Kenny Trang; Gilda Lai; Gadi Wollstein; Hiroshi Ishikawa; Ronald Zambrano; Ezekiel Ede; Christopher Leung; Jeffrey L Goldberg; Joel S Schuman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2955 – F0108. doi:
Retinal Ischemia Rather than Neovascularization is Associated with Neovascular Glaucoma in Patients with Proliferative Diabetic Retinopathy Using Widefield Swept-Source Optical Coherence ... Open Access
Edward S Lu; Ying Cui; Rongrong Le; Ying Zhu; Jay C Wang; Ines Lains; Raviv Katz; Yifan Lu; Rebecca Zeng; Itika Garg; David M Wu; Deeba Husain; Leo A Kim; John B Miller
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2952 – F0105. doi:
Preclinical Animal Model for Functional Biocompatibility of a Novel VEGF and Ang-2 Bispecific Protein (RO-634) Using ERG Analysis Open Access
Nikhil Gupta; Jeffrey L Olson; Anthony Jones; Josh Morgenstern; Anne Strong; Steven Droho; Shaun Bevers; Niklaus Mueller; Michael Huvard; Li Xu; Peter K Kaiser; Arshad M. Khanani; Jeffrey S Heier; Alina Sinha; Evan Sembell; Ramanath Bhandari
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 286 – F0089. doi:
Survey of Alternative Treatments for Glaucoma Patton, A.; Pandher, M.; Khouri, AS Open Access
Alisa Patton; Meher Pandher; Albert Khouri
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2843 – A0366. doi:
Evaluation of Tear and Anterior Chamber Fluid Samples for Benzalkonium Chloride During Long-Term Glaucoma Treatment Open Access
Giedre Pakuliene; Loreta Kuzmiene; Vaidotas Zvikas; Brent A Siesky; Alice Chandra Verticchio Vercellin; Valdas Jakstas; Alon Harris; Ingrida Januleviciene
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2842 – A0365. doi:
Voretigene Neparvovec Exploratory Analysis (VNEAN): R-shiny app for the comprehensive and dynamic visualization of voretigene neparvovec clinical trial data Open Access
Iryna Lobach; Claudio Spera; Maria Agustina Vacarezza; Jahangir Alam
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2827 – A0343. doi:
Gender differences in private industry payments to optometrists in 2019 Open Access
wing yip; Muriel Schornack; Cherie B Nau; michael mahr
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2787 – A0117. doi:
Risk Factors For Cancellation of Ophthalmic Surgery Open Access
Abhinav Bheemidi; Roshni Kailar; Carolina Carvalho Soares Valentim; Aneesha Kalur; Rishi P Singh; Katherine Talcott
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2786 – A0116. doi:
Clinical indicators for assessment of optometric diabetic eyecare in Australia Open Access
Rajendra Gyawali; Melinda Toomey; Fiona Stapleton; Kam Chun Ho; Lisa Keay; Alex Gentle; Ann Louise Webber; David Cecil Pye; Gerald Liew; Yan Inez Hsing; Jacqueline Ramke; Katrina L Schmid; Paula Katalinic; Sharon Bentley; Isabelle Jalbert
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2785 – A0115. doi:
Cost-Effectiveness of a School-Based Screening Program in Indonesia for Identifying and Treating Schoolchildren with Refractive Error Open Access
Rahul Seshadri Iyengar; Michael Krautmann; Satyaprabha Kotha; John Macom; Nicholas Kourgialis; Joshua R Ehrlich
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2784 – A0114. doi:
Visual adaptation to different levels of peripheral optical scattering Open Access
Antonia Neumann; Katharina Breher; Siegfried Wahl
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2564 – F0518. doi:
tRNS and exercise do not modulate ocular dominance plasticity Open Access
Xiaoxin Chen; Kennedy Hall; Amy Nguyen; Grant Sealock; Tiffany Tran; Nicholas Vo; Benjamin Thompson; Arijit Chakraborty
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2547 – F0501. doi:
Optical coherence tomography risk factors for 3-year development of atrophy in eyes with age-related macular degeneration Open Access
Kazutaka Hirabayashi; Srinivas R Sadda; Hannah Yu; Kenneth Marion; Charles Clifton Wykoff
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2532 – A0101. doi:
AREDS Supplementation and Complement System Levels in Patients with Intermediate Age-Related Macular Degeneration Open Access
Itzam Marin; Brandie D. Wagner; Niranjan Manoharan; Alan Palestine; Felix Poppelaars; Jennifer L. Patnaik; Michael Holers; Ashley Frazer-Abel; Marc Mathias; Naresh Mandava; Anne M. Lynch
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2531 – A0100. doi:
The importance of Slc16a8 in light-induced retinal degeneration Open Access
Bailey Hannon; Navid Nouri; TOM TRUONG; Gyeong Jin Kang; Brian Yaspan; Heinrich Jasper; Shawnta Y Chaney
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2470 – F0177. doi:
Scotoma Replacement: simulation of vision with photoreceptor scotoma Open Access
Eli Peli; Robert Goldstein; Jae-Hyun Jung
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2464 – F0041. doi:
Single-Shot Optical Coherence Elastography at 11.5 MHz Open Access
Manmohan Singh; Alexander W. Schill; Achuth Nair; Salavat R Aglyamov; Irina V. Larina; Kirill Larin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2383 – A0186. doi:
Optical Coherence Tomography Findings in Choroidal Melanoma-Associated Subretinal Fluid Open Access
Melis Kabaalioglu Guner; Timothy W Olsen; Lauren A Dalvin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2344 – A0013. doi:
Systematic Review and Meta-Analysis of Long-Term Metastasis-free Survival in Untreated Uveal Melanoma Open Access
Gustav Stålhammar; Viktor T Gill
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2341 – A0010. doi:
Integrative omics approach identifies druggable BAP1-dependencies in Uveal Melanoma Open Access
Luisa Silva; Sarah Barnett; Jenna Kenyani; Zohra Butt; Karen Aughton; Dean Hammond; Azzam Taktak; Joseph Sacco; Helen Kalirai; Sarah E Coupland; Judy Coulson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2340 – A0009. doi:
Evaluation of Depth Perception During a Light Field Head-Mounted Display Open Access
Masakazu Hirota; Kakeru Sasaki; Kanako Kato; Ryusei Takigawa; Tetsuro Morimoto; Shigenobu Yoneyama; Takao Hayashi; Atsushi Mizota
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2255 – F0463. doi:
A physiologically based simulation of anomalous trichromacy Open Access
Dragos Rezeanu; Rachel Barborek; Maureen Neitz; Jay Neitz
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2240 – F0448. doi:
Semi-automatic segmentation for gonioscopic images Open Access
Giusi Spagnuolo; Andrea De Giusti
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 223 – F0070. doi:
MUTED: Reveal the hidden structures of cataractous retinal images Open Access
Shuhe Zhang; Ashwin Mohan; Carroll A. B. Webers; Tos TJM Berendschot
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 222 – F0069. doi:
Detection of Reticular Pseudodrusen on Embossed Color Fundus Photos Open Access
Shin Kadomoto; Muneeswar Gupta nittala; Ayesha Nuri Karamat; Onnisa Nanegrungsunk; Srinivas R Sadda
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 221 – F0068. doi:
AOSLO Image Quality: Quantifying the Good, the Bad and the Ugly Open Access
Brea D Brennan; Heather Heitkotter; Joseph Carroll; Robert F Cooper
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 220 – F0067. doi:
Novel Lens Correction Method in Flavoprotein Fluorescence Imaging Open Access
Justin Muste; Matthew Russell; Collin Rich; Kurt Riegger; Rishi P Singh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 219 – F0066. doi:
Ethnic Differences in the Distribution of Diabetic Lesions Open Access
Ye He; Muneeswar Gupta nittala; Aditya Verma; Houri Esmaeilkhanian; Swetha Bindu Velga; Xiaorong Li; Long Su; Xiao Li; Irena Tsui; Pradeep Prasad; Chaitra Jayadev; Srinivas R Sadda
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2160 – F0223. doi:
MEDICARE randomized trial: intravitreal aflibercept treatment versus pan-retinal photocoagulation in the regression of neovascularisation in proliferative diabetic retinopathy Open Access
Guillaume Tardieu; Maher Saleh; Gil Pebayle; Maxime Bolet; Pierre Ingrand; Nicolas Leveziel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2158 – F0221. doi:
Availability of Social Determinants of Health Data for Ophthalmology Patients in Electronic Health Records Open Access
Mahasweta Nayak; Terrence Cheng-Yuan Lee; Bharanidharan Radha Saseendrakumar; Alison X. Chan; John J. McDermott IV; Bita Shahrvini; Gordon Y. Ye; Amy M. Sitapati; Camille Nebeker; Sally Baxter
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2132 – A0160. doi:
The Impact of Travel Distance on Rhegmatogenous Retinal Detachment Presentation and Outcomes Open Access
Sarah Rahman; Matthew Russell; Julia Joo; Carolina Carvalho Soares Valentim; Rishi P Singh
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2131 – A0159. doi:
In vitro safety evaluation of two eye drops solutions containing a combination of corticosteroid and antibiotic. Open Access
Santa Viola; Giuseppe De Pasquale; Maria Cristina Curatolo; MARIA GRAZIA MAZZONE; Cristina Zappulla
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2114 – F0130. doi:
Antimicrobial efficacy of netilmicin against Staphylococci administered two or four times a day. Open Access
Cristina Zappulla; Maria Cristina Curatolo; Andrea Sudano Roccaro; MARIA GRAZIA MAZZONE; Carmela Giovanna Spoto
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2113 – F0129. doi:
Predicting progression to referable diabetic retinopathy from retinal images and screening data using deep learning Open Access
Paul Nderitu; Joan Nunez do Rio; Laura Webster; Samantha Mann; David Hopkins; Jorge Cardoso; Marc Modat; Christos Bergeles; Timothy L Jackson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2087 – F0076. doi:
Predicting 5-year progression to vision-threatening complications using machine learning Open Access
Dimitrios Damopoulos; Luís Mendes; Torcato Santos; Ales Neubert; Daniela Ferrara; Jose G Cunha-Vaz; Fethallah Benmansour
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2085 – F0074. doi:
A unified deep learning approach for OCT segmentation from different devices and retinal diseases Open Access
Alvaro Gomariz; Huanxiang Lu; Yun Li; Thomas Albrecht; Andreas Maunz; Fethallah Benmansour; Jennifer Luu; Orcun Goksel; Daniela Ferrara
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2053 – F0042. doi:
Convolutional Neural Network for Glaucoma detection using Compass color fundus images Open Access
CHIARA RUI; Silvia Gazzina; Giovanni Montesano; David P. Crabb; David F Garway-Heath; Francesco Oddone; Paolo Lanzetta; Paolo Brusini; Chris A Johnson; Paolo Fogagnolo; Luca M Rossetti
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2039 – A0480. doi:
Assessing Usability and Clinical Utility of GLANCE, an Artificial Intelligence-based Tool for Predicting Glaucoma Visual Field Progression Open Access
Alexander Lieu; Astrid van den Brandt; Mark Christopher; Derek Stuart Welsbie; Jiun Lap Do; Andrew Camp; Sasan Moghimi; Sally Liu Baxter; Linda M Zangwill
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2008 – A0449. doi:
Visualization of the inhibition and disruption of immunological synapses by lifitegrast using a live cell imaging assay Open Access
Yi Bao; Aditi Malu; Charis Lau; Scott Geller
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2004 – A0334. doi:
Point of Care Diagnosis of Dry Eye Disease with Sensitive Dual Biomarker Detection Open Access
Sydney Danchang Zhang; Dorothy Wang
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 2001 – A0331. doi:
Tear film breakup and dynamics analyzed and displayed with pseudo-color images Open Access
Peter Ewen King-Smith; Carolyn G Begley; Richard J Braun
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1973 – A0303. doi:
Narrow-band, long-wavelength lighting caused hyperopia in normal eyes and retarded minus lens-induced myopia and form deprivation myopia for juvenile tree shrews Open Access
Zhihui She; Thomas T Norton; Timothy Gawne
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1889 – A0018. doi:
Simulated myopic defocus counteracts a myopiagenic environment in juvenile tree shrews producing hyperopia Open Access
Timothy Gawne; Zhihui She; Thomas T Norton
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1886 – A0015. doi:
Analysis of Variability of the Spiral of Tillaux and Corneal Diameters: a Cadaveric Study Open Access
Eric Kim; Viren Rana; Andrew Barton; Joshua Tanzer; Jamie Schaefer
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1877 – A0006. doi:
Evaluation of reading performance with progressive power lenses using eye tracking technology Open Access
Pablo Concepcion Grande; Amelia González; Paulina Dotor Goytia; Eva Chamorro; Jose Miguel Cleva; Jose Alonso; Jose Antonio Gómez-Pedrero
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1816 – F0432. doi:
SARM1 Inhibition Protects Photoreceptors from NMNAT1-related Retinal Degeneration and is a Potential Approach to Other Models of Photoreceptor Degeneration Open Access
Tim Lee; Yo Sasaki; Joseph Lin; Rajendra S Apte
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1769 – F0318. doi:
Development of an Artificial Intelligence Classifier for Follicular Trachoma Open Access
Christopher J Brady; R. Chase Cockrell; Damien Socia; Sheila K West
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 173 – F0020. doi:
Biofeedback Training to improve visual functions and quality of life post brain injury Open Access
Yulia Pyatova; Michelle Markowitz; Samuel N Markowitz; Monica Daibert-Nido
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1721 – F0039. doi:
Automatic Blepharoptosis Measurement by Iris Edge Detection with a Deep Learning Model Open Access
Ke-Wei Chen; Perera Chandrashan; Hsu-kuang Chiu; Andrea Lora Kossler; Myung David; Chiou-Shann Fuh; Cherng-Ru Hsu; Ming-Chun Tseng; Shu-Lang Liao; Ju Yi Hung
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 172 – F0019. doi:
Impact of COVID-19 on Glaucoma Patients' Perception of Care Open Access
Justin K Tram; Kathryn Lee; Jennifer Bu; Sai Gandham
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1713 – F0031. doi:
Patient Satisfaction with the Symfony Intraocular Lens Open Access
Nirali Shah; Michael E Rauser
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1686 – F0004. doi:
Long-term mortality in patients with neovascular glaucoma following tube-shunt surgery Open Access
Eli Cehelyk; Eric Shiuey; Sonam Patel; Natasha N Kolomeyer; Jonathan S Myers; Daniel Lee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1627 – A0122. doi:
Treatment of Pediatric Lyme Meningitis with Neuro-Ophthalmic Complications: A Case Series Open Access
Viren Rana; Eric Kim; Paul B Greenberg; Tatiana Bakaeva; Wendy Chen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1574 – A0363. doi:
COVID-19 Associated Optic Neuritis Open Access
Kajal Sangal; Viviana Barquet-Piza; Jeffrey Nichols
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1570 – A0359. doi:
Sex-Related Differences and Hormonal Effects in the Dry Eye Assessment and Management (DREAM) Study Open Access
Megan Zhao; Yinxi Yu; Neeta Roy; Gui-Shuang Ying; Penny A Asbell; Vatinee Y Bunya
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1511 – A0236. doi:
Association of proton pump inhibitors use with severity of dry eye symptoms and signs in the DRy Eye Assessment and Management (DREAM©) Study Open Access
Yinxi Yu; Penny A Asbell; Gui-Shuang Ying
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1510 – A0235. doi:
Demographic Differences of Dry-Eye Disease Between Pediatric and Adult Patients in the IRIS Registry Open Access
Nathan Hall; Vivian Paraskevi Douglas; Connor Ross; Joan W Miller; Alice Carlyle Lorch; Aisha Traish
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1507 – A0232. doi:
Face-Mask Associated Dry Eye (F-MADE) Symptoms and Ocular Surface Alterations Open Access
David Jimenez-Collado; Norma Morales; Carlos Adolfo Müller-Morales; Arturo Ramírez-Miranda; Enrique O Graue-Hernandez; Alejandro Navas
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1505 – A0230. doi:
Discovery and preclinical development of VVN539，a novel ROCK and NO dual MOA agent for the treatment of glaucoma in normotensive rabbits model with minimal hyperemia. Open Access
Yong Li; Lili Yao; Kuifeng Dang; Qiao Han; Caroline Lu; Erning Xia; Wang Shen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 150 – A0343. doi:
Intraocular pressure sensitivity and specificity in ocular hypertension and open-angle glaucoma with Goldmann and modified Goldmann tonometry Open Access
Sean Joseph McCafferty
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 149 – A0342. doi:
Wavefront superposition for predicting retinal image quality with zonal, dual-focus and multifocal contact lenses Open Access
Mateusz Jaskulski; Percy Lazon de la Jara; Arthur Bradley; Pete S Kollbaum
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1440 – F0398. doi:
Community Based Eye Screenings Using Retinal and OCT-B Combination Imaging in Glaucoma During COVID-19 Open Access
Rashika Verma; Priya Tailor; Aretha Zhu; Catherine Ye; Eric J Kuklinski; Neelakshi Bhagat; Bernard Szirth; Miriam Habiel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1384 – A0080. doi:
Agreeability of Tele-ophthalmology and Artificial Intelligence-Based Diagnosis of Diabetic Retinopathy Open Access
Eric J Kuklinski; Roger K Henry; Megh Shah; Priya Tailor; Rashika Verma; Aretha Zhu; Marco A Zarbin; Bernard Szirth; Neelakshi Bhagat
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1383 – A0079. doi:
Deep Learning Artificial Intelligence in Vision-Threatening Disease in Clinical and Community Screenings Open Access
Aretha Zhu; Isis Zhang; Priya Tailor; Rashika Verma; Catherine Ye; Eric Kuklinski; Bernard Szirth; Miriam Habiel; Albert Khouri
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1381 – A0077. doi:
Robotic Telepresence Consults in Underserved Community-Based Vision Threatening Disease Screenings During COVID-19 Open Access
Priya Tailor; Aretha Zhu; Rashika Verma; Eric Kuklinski; Catherine Ye; Bernard Szirth; Albert Khouri; Miriam Habiel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1379 – A0075. doi:
Artificial Intelligence to Identify Retinal OCT Parameters Predictive of Patient Visual Outcomes under a Treat-and-Extend Regimen Open Access
Hrvoje Bogunovic; Gregor Sebastian Reiter; Oliver Leingang; Ursula Schmidt-Erfurth
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1346 – F0180. doi:
Use of spatial filters for improved detection of glaucomatous visual field progression Open Access
Yan Li; Runjie Bill Shi; Willy Wong; Yvonne Buys; Graham E Trope; Moshe Eizenman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1253 – A0393. doi:
Pointwise Comparison of the 24-2C and 10-2 for Central Field Defects Open Access
Luke Harrison; Andrew Chen; Philip P Chen; Preston Luong
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1251 – A0391. doi:
Impact of Neurotrophic Keratopathy on Eye Pain and Quality-of-Life-Related Parameters in Patients with Ocular Graft-Versus-Host Disease Open Access
Shudan Wang; Rohan Bir Singh; Erdem Yuksel; Thomas H Dohlman; Reza Dana
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1208 – A0208. doi:
Dual optical coherence tomography and microscopy for topographical and cellular evaluation of the cornea Open Access
Cristina Canavesi; Andrea Cogliati; Holly B Hindman
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1188 – A0188. doi:
Gender distribution in Ophthalmology Subspecialties between 1992 and 2020 Open Access
Benjamin Steren; Philina Yee; Shu Feng; Kathryn L Pepple; Ninani Kombo
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1064 – A0159. doi:
GA area measured by SD-OCT shows good correspondence with FAF-based measurements in patients enrolled in the FILLY trial Open Access
Julia Mai; Dmitrii Lachinov; Sophie Riedl; Gregor Sebastian Reiter; Wolf-Dieter Vogl; Hrvoje Bogunovic; Ursula Schmidt-Erfurth
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 1015 – F0262. doi:
Molecular mechanisms mediating diabetic retinal neurodegeneration: Role of Cell Adhesion Molecules Open Access
Harshini Chakravarthy; Sapana Sharma; Shruti Shree; Vasudharani Devanathan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 774 – F0333. doi:
Toxicity of a stable phospholipid mixture on human retinal pigment epithelium cells Open Access
Christopher Dafu Yang; Jordan Jessen; Marzieh Ataei; M.Cristina Kenney; Abraham Phillip Lee; Ken Young Lin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 75 – A0048. doi:
Drosophila models of SNRNP200-associated retinitis pigmentosa exhibit retinal apoptosis and abnormal electroretinograms Open Access
Sara Kathryn Mayer; Quinton Christenson; Arlene V Drack; Lori L Wallrath
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 737 – F0389. doi:
Virtual Reality Enables Rapid, Multi-Faceted Retinal Function Screenings Open Access
Margarita Labkovich; Andrew Warburton; Oluwafeyikemi Okome; Christopher Cheng; Randal Serafini; Malin Sara Hovstadius; James Chelnis
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 713 – F0441. doi:
The Immunohistochemical Analysis of Cellular Auto-Degradative Functions in Epithelial Cells of the Anterior Capsule of Lens in Patients with Pseudo-Exfoliation Syndrome: A Preliminary Rep... Open Access
Sadi Can Sonmez; Melisa Zisan Karslioglu; Dilara Aydemir; Merve Gozel; Zeynep Busra Kisakurek; Afsun Sahin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 655 – F0010. doi:
Do Normative Percentiles of Retinal Nerve Fiber Layer Thickness (RNFLT) Improve Prediction of Glaucomatous Visual Field Loss? Open Access
Rishabh Singh; Yangjiani Li; Mohammad Eslami; Saber Kazeminasab; Nazlee Zebardast; Mengyu Wang; Tobias Elze
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 633 – A0373. doi:
Structure and function comparison of cup/disc ratio and perimetric mean deviations Open Access
Katharina G. Foote; Patricia Sha; Tara Pahlevan-Chaleshtari; Iryna A. Falkenstein; Todd Severin; Gary C Lee; Thomas Callan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 628 – A0368. doi:
OCT Probability Change Maps for Detection of Early Glaucomatous Progression Open Access
Sol La Bruna; Emmanouil (Manos) Tsamis; Ari Leshno; Anvit Rai; Gustavo De Moraes; Donald C Hood
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 627 – A0367. doi:
Change in Blink Rate Following Botulinum Toxin Injection in Benign Essential Blepharospasm Open Access
Ghasem Yazdanpanah; Michael Tze-Chien Yen; Stephen C Pflugfelder
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 607 – A0308. doi:
A Systematic Review of Electrocautery Use During Ocular and Oculofacial Surgery in Patients with Implantable Electronic Cardiovascular Devices Open Access
Jenna Tauber; Jennifer Patricia Tingley; Anne Barmettler
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 600 – A0301. doi:
Race and Insurance based differences in the outcome of anti-vascular endothelial growth factor treatment of diabetic retinopathy - an analysis of 43,274 patient eyes using the IRIS® Regis... Open Access
Jay Maturi; Vikas rammohan Maturi; Charles Li; Flora Lum; Thomas A Ciulla; Raj K Maturi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 565 – A0130. doi:
Seeing in Color: Inclusion and Characterization of African Americans in Hereditary Eye Disease Research Open Access
Agnes C Ezekwesili; Raisa Ionin; Laryssa Huryn; Catherine A Cukras; Delphine Blain; Aime Agather; Robert B Hufnagel; Brian Patrick Brooks; Wadih M Zein
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 501 – A0078. doi:
Effects of Quercetin in AMD Cybrid Cell Lines: Implications for a Therapeutic Role in AMD Open Access
Nasim Salimiagdam; Marilyn Chwa; Anthony Nesburn; M.Cristina Kenney
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 467 – A0004. doi:
Influence of rigid lens position on visual image quality in normal and keratoconic eyes Open Access
Jos J Rozema; Gareth D Hastings; Marta Jiménez-García; Carina Koppen; Raymond A Applegate
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4541 – F0455. doi:
Cone structure and function in RPGR- and USH2A-associated retinal degenerations Open Access
Paul S Micevych; Jessica Wong; Hao Zhou; Ruikang K Wang; Travis Porco; Austin Roorda; Jacque L Duncan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4530 – F0317. doi:
Safe Delivery Through 20G Trocar of Soft Mono Layer Retinal Pigment Epithelium Implant Open Access
Gilad Rabina; Lior Rosenberg Belmaker; Ariel Eisenbach; Dorin Sade; Maayan Malki [email protected]; Michal Marcus; Yishay Hayardeni; Amos Eitan
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4506 – F0293. doi:
Safety of intravitreal allogeneic mesenchymal stem cells for Acute Non-Arteritic Optic Neuropathy. Pilot study Open Access
Jose-Carlos Pastor; Salvador Pastor-Idoate; Marina Lopez-Paniagua; Marta Para; Francisco Blazquez; Esther Murgui; Rosa Coco-Martin
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4500 – F0287. doi:
Investigating the genetic and clinical features associated with cystoid macular edema in retinitis pigmentosa patients Open Access
Juan David Arias; Fritz Kalaw; Varsha Alex; Shaden Yassin; Henry Ferreyra; Evan Walker; Shyamanga Borooah
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4484 – F0271. doi:
Optical coherence tomography imaging quality in patients with retinitis pigmentosa without mydriatic eye drops Open Access
Santiago Mejia-Freire; Milagros Mateos-Olivares; Francisco Javier Valentín Bravo; Eva M Sobas Abad; Ricardo Usategui Martin; Jose-Carlos Pastor; Salvador Pastor
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4482 – F0269. doi:
Handheld ultra-widefield optical coherence tomography Open Access
Shuibin Ni; Thanh-Tin P. Nguyen; Ringo Ng; Shanjida Khan; Susan Ostmo; Yali Jia; Michael F Chiang; David Huang; J. Peter Campbell; Yifan Jian
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4450 – F0129. doi:
Ultrasound-Activated Perfluorocarbon (PFC) Nanodroplets for Treatment of Glaucoma Open Access
Ronald H Silverman; Mark Burgess; Raksha Urs; Jeffrey A Ketterling; Gulgun Tezel
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4410 – F0089. doi:
Ultrasound biomicroscopy correlation with corneal diameter in pediatric patients Open Access
Taylor Kolosky; Anusha U Saga; Moran Roni Levin; Janet L. Alexander
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4401 – F0080. doi:
Evaluation of lenticular and zonular changes in patients with Marfan syndrome using ultrasound biomicroscopy Open Access
Suzanne Daly; D Jackson Coleman; Ronald H Silverman; Aliaa H. Abdelhakim; Lisa Park; Irene H Maumenee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4398 – F0077. doi:
Posterior Eyeball Topography based on Three-dimensional Magnetic Resonance Imaging and Optic Nerve Head Morphology Open Access
Kyoung Min Lee; Hyoung Jun Ahn; Jung Hyo Rhim; Martha Kim; Sohee Oh; Sun-Won Park; Jae Hun Kim; Seok Hwan Kim
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4397 – F0076. doi:
Practice Compliance in Documenting and Billing Gonioscopy and Pachymetry in a Resident Ophthalmology Clinic Open Access
Angelica Garcia; Kent L Anderson
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4393 – A0436. doi:
Patient-specific simulation of refractive surgery: Biomechanics and modeling of CLEAR human lenticules Open Access
Malavika Nambiar; Layko Liechti; Theo G Seiler; Philippe Büchler
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4366 – A0303. doi:
Optimizing Photorefractive Keratectomy Oucomes in Myopia with Topical Mitomycin C Open Access
Elizabeth Miller Bolton; Nigel Zhang; Paul Bryar; Robert Feder
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4365 – A0302. doi:
CORNEAL GRAFT REJECTIONS DUE TO COVID 19 INFECTION OR VACCINATIONS : A CASE SERIES Open Access
Ansu Ann John; Himanshu P Matalia; Nandini C
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4341 – A0278. doi:
Influence of Myopic Correction and Axial Length on ON-OFF Perimetry Open Access
Stephen Dellostritto; Mitchell W Dul; Jia Tan; Veronica Moore-Stoll; Hamed Rahimi Nasrabadi; Jian Zhong Jin; Jose-Manuel Alonso
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4325 – A0030. doi:
Retinal Thickness and Visual Acuity in Eyes with Different Types of Astigmatism Open Access
Dong LIANG; Tsz Wing Leung; Chea-Su Kee
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4211 – A0139. doi:
Effect of IGF-1 Administration on Retinopathy in a Low-Birth-Weight Rat Model of Oxygen-Induced Retinopathy Open Access
Yuta Saito; Kota Yokoyama; Hidetoshi Onda
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4126 – F0363. doi:
Ultrahigh resolution OCT, volume merging, and advanced signal reconstruction improve visualization of the RPE-Bruch’s complex Open Access
Stefan B Ploner; Siyu Chen; Eric Moult; Lennart Husvogt; Julia Schottenhamml; Nadia K Waheed; James G Fujimoto; Andreas Maier
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4077 – F0041. doi:
Quantification of Quasi-IPE Structure in PS-OCT Images Open Access
Lingxi Hu; Xiaoling Li; Bing Yang; Masahiro Yamanari; Linsheng Liu; Keiichiro Okamoto; Risa Higashita; Jiang Liu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4076 – F0040. doi:
Spectral-domain optical coherence tomography morphological characteristics in patients with cone dystrophy Open Access
Hassan khojasteh; Fatemeh Bazvand; mostafa haidari; Alireza Mahmoudi; S.Saeed Mohammadi; Hamid Riazi Esfahani; Masoud Mirghorbani; Afsaneh Azarkish; Jonathan Regenold; Amir Akhavanrezayat; Irmak Karaca; SungWho Park; Gunay Uludag; Chi Mong Or; Hashem Ghoraba; Quan Dong Nguyen
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4075 – F0039. doi:
Investigating hyalocyte-like cells in epiretinal membranes using serially acquired optical coherence tomography Open Access
Brian Soetikno; David Andrew Miller; Hao Zhang; Jeffrey L Goldberg; Theodore Leng; Alfredo Dubra
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4074 – F0038. doi:
Retinal optical coherence tomography identifies early biomarkers for neurodegenerative disease and future cognitive decline Open Access
Sayuri Sekimitsu; Sarah Shareef; Yan Zhao; Tobias Elze; Ayellet V. Segrè; Janey L Wiggs; Nazlee Zebardast
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 4073 – F0037. doi:
Retinal Magnification Factor Derived from Individualized Four-Surface Schematic Eye using Real Ray Tracing Open Access
Xiaojing Huang; Alfredo Dubra
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 401 – F0439. doi:
Association between systematic use of bio-occlusive dressing to reduce general anesthesia-associated corneal injury Open Access
Muhammad Zain Chauhan; Riley N Sanders; Abdelrahman Elhusseiny; Ahmed Sallam
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3958 – A0238. doi:
Data and Analysis from Tear Breakup (TBU) in Normal Subjects Open Access
Richard J Braun; Tobin A Driscoll; Dominck Sinopoli; Julianna Dorsch; Caroline Hammond; Rayanne A Luke; Carolyn G Begley
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3950 – A0230. doi:
Changes in quality of life (QoL) in a 24-month interval in patients with non-acute Vogt-Koyanagi-Harada disease (VKHD) Open Access
Fernanda Maria Silveira Souto; Ruy Felippe Missaka; Marcelo Mendes Lavezzo; Priscilla Figueiredo Nóbrega; Viviane Mayumi Sakata; Breno Marchiori Magalhães; Victor Marcos Couto Caetano; Julia Thiemi Takiuti; Maria Kiyoko Oyamada; Carlos Eduardo Hirata; Joyce H Yamamoto
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3923 – A0466. doi:
Communications Between Adipose-Derived Mesenchymal Stem Cells (AdMSCs) and Retinal Pigment Epithelial Cell Line (RPE-1) in Different Stress Environments via Tunneling Nanotubes Open Access
merve gözel; Dilara Aydemir; Karya Senkoylu; Berk Kabadayi; Afsun Sahin; Murat Hasanreisoglu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3883 – A0085. doi:
Indications and Outcomes for Laser Retinopexy in Patients with Lattice Degeneration Open Access
Adina S Kazan; Raziyeh Mahmoudzadeh; Mirataollah Salabati; Marc Spirn
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3794 – F0215. doi:
Efficacy of Kahook Dual Blade Goniotomy with and without Phacemulsification in an Urban Population: A Retrospective Study Open Access
David Vi Tran; Shibandri Das; Chaesik Kim; Bret A Hughes; Mark Juzych; Christian Mehregan; Faisal Ridha Al-Timimi
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3686 – A0371. doi:
A Comparison of the XEN Gel Stent and Ahmed Valve Devices in Preventing Postoperative Hypotony in Patients with Primary Open Angle Glaucoma Open Access
Patrick Bojie Wu; Fredric J Gross; N Rao Chaganty
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3682 – A0367. doi:
EFFECTIVENESS OF TREATMENT OF ABDUCENT NERVE PALSY/PARESIS WITH BOTULINUM TOXIN TYPE A (BTA) INJECTION: ANALYSIS OF 10 CASES Open Access
lucas Barasneviciusvicius quagliato; Pedro Davila Souza Fraiha; Debora Muriel Müller; Thaisy Ventura Batistel; Sabrina Martins Leite; Elizabeth Barasnevicius Quagliato; Elvira Barbosa Abreu
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3667 – A0324. doi:
Topographical Differences Vary Significantly Across All Retinal Layers in the Early Stages of Age-related Macular Degeneration Open Access
Matt Trinh; Michael Kalloniatis; David Alonso-Caneiro; Lisa Nivison-Smith
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 361 – F0192. doi:
Predictors of long-term ophthalmic complications after closed globe injuries using the IRIS® Registry (Intelligent Research in Sight) Open Access
Ashley Batchelor; Matthew Hunt; Megan Lacy; Cecilia S Lee; Aaron Y Lee; Yewlin Chee; Steven Saraf
Investigative Ophthalmology & Visual Science June 2022, Vol.63, 3540 – A0120. doi:
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