Volume 63 Issue 9 | IOVS

Anatomy and Pathology/Oncology

UBE2T/STAT3 Signaling Promotes the Proliferation and Tumorigenesis in Retinoblastoma Open Access

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Nuo Xu; Yi Cui; Hong Shi; Guodong Guo; Fengyuan Sun; Tianming Jian; Huiying Rao

Tags: retinoblastoma, stat3 protein, tumorigenesis, signal transduction

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 20. doi:https://doi.org/10.1167/iovs.63.9.20

Biochemistry and Molecular Biology

Gene Expression Signatures of Contact Lens-Induced Myopia in Guinea Pig Retinal Pigment Epithelium Open Access

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So Goto; Sandra E. Muroy; Yan Zhang; Kaoru Saijo; Sree Rohit Raj Kolora; Qiurong Zhu; Christine F. Wildsoet

Tags: eye, gene expression, guinea, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 25. doi:https://doi.org/10.1167/iovs.63.9.25

Clinical and Epidemiologic Research

Macular Layer Thickness and Effect of BMI, Body Fat, and Traditional Cardiovascular Risk Factors: The Tromsø Study Open Access

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Therese von Hanno; Live Lund Hareide; Lars Småbrekke; Bente Morseth; Monica Sneve; Maja Gran Erke; Ellisiv Bøgeberg Mathiesen; Geir Bertelsen

Tags: body fat, body mass index procedure, heart disease risk factors, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 16. doi:https://doi.org/10.1167/iovs.63.9.16

Ambient Air Pollution and Age-Related Eye Disease: A Systematic Review and Meta-Analysis Open Access

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Alyssa Grant; Gareth Leung; Ellen E. Freeman

Tags: air pollution, eye diseases, meta-analysis, systematic reviews, glaucoma

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 17. doi:https://doi.org/10.1167/iovs.63.9.17

Palpebral Fissure Response to Phenylephrine Indicates Autonomic Dysfunction in Patients With Type 1 Diabetes and Polyneuropathy Open Access

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Thomas Arendt Nielsen; Carl Uggerhøj Andersen; Henrik Vorum; Sam Riahi; Rok Sega; Asbjørn Mohr Drewes; Jesper Karmisholt; Poul Erik Jakobsen; Birgitte Brock; Christina Brock

Tags: autonomic dysfunction, diabetes mellitus, type 1, dysautonomia, heart rate variability, palpebral fissure

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 21. doi:https://doi.org/10.1167/iovs.63.9.21

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Interocular Transfer: The Dichoptic Flash-Lag Effect in Controls and Amblyopes Open Access

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Xi Wang; Yutong Song; Meng Liao; Robert F. Hess; Longqian Liu; Alexandre Reynaud

Tags: amblyopia, retinal correspondence

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 2. doi:https://doi.org/10.1167/iovs.63.9.2

Genetics

Consequences of a Rare Complement Factor H Variant for Age-Related Macular Degeneration in the Amish Open Access

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Andrea R. Waksmunski; Kristy Miskimen; Yeunjoo E. Song; Michelle Grunin; Renee Laux; Denise Fuzzell; Sarada Fuzzell; Larry D. Adams; Laura Caywood; Michael Prough; Dwight Stambolian; William K. Scott; Margaret A. Pericak-Vance; Jonathan L. Haines

Tags: age-related macular degeneration, alleles, complement factor h, proteins, c-reactive protein

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 8. doi:https://doi.org/10.1167/iovs.63.9.8

An Insertion Variant in CRH Confers an Increased Risk of Central Serous Chorioretinopathy Open Access

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En-Zhong Jin; Tian-Qi Li; Chi Ren; Li Zhu; Wei Du; Jin-Feng Qu; Yu-Ou Yao; Xiao-Xin Li; Peng Zhou; Lv-Zhen Huang; Ming-Wei Zhao

Tags: central serous chorioretinopathy

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 9. doi:https://doi.org/10.1167/iovs.63.9.9

Dominant Cone Rod Dystrophy, Previously Assigned to a Missense Variant in RIMS1, Is Fully Explained by Co-Inheritance of a Dominant Allele of PROM1 Open Access

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Maria Pilar Martin-Gutierrez; Elena R. Schiff; Genevieve Wright; Naushin Waseem; Omar A. Mahroo; Michel Michaelides; Anthony T. Moore; Andrew R. Webster; Gavin Arno; for the Genomics England Research Consortium

Tags: alleles, genetic inheritance, progressive cone-rod dystrophy, retinitis pigmentosa, family

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 14. doi:https://doi.org/10.1167/iovs.63.9.14

Clinical and Genetic Analysis of RDH12-Associated Retinopathy in 27 Chinese Families: A Hypomorphic Allele Leads to Cone-Rod Dystrophy Open Access

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Junwen Wang; Yingwei Wang; Shiqiang Li; Xueshan Xiao; Zhen Yi; Yi Jiang; Xueqing Li; Xiaoyun Jia; Panfeng Wang; Chenjin Jin; Wenmin Sun; Qingjiong Zhang

Tags: alleles, family, retinal diseases, retinitis pigmentosa, genetic analysis

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 24. doi:https://doi.org/10.1167/iovs.63.9.24

Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children Open Access

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Joanna Swierkowska; Justyna A. Karolak; Sangeetha Vishweswaraiah; Malgorzata Mrugacz; Uppala Radhakrishna; Marzena Gajecka

Tags: child, dna methylation, genes, methylation, myopia

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 31. doi:https://doi.org/10.1167/iovs.63.9.31

Glaucoma

A Mathematical Model of Aqueous Humor Production and Composition Open Access

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Mariia Dvoriashyna; Alexander J. E. Foss; Eamonn A. Gaffney; Rodolfo Repetto

Tags: aqueous humor, hypertension, ion channels, mass or substance concentration per volume, mathematical model

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.9.1

Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma Open Access

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Jae H. Kang; Oana Zeleznik; Lisa Frueh; Jessica Lasky-Su; A. Heather Eliassen; Clary Clish; Bernard A. Rosner; Louis R. Pasquale; Janey L. Wiggs

Tags: exfoliation syndrome, metabolites, plasma, metabolomics

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 15. doi:https://doi.org/10.1167/iovs.63.9.15

Immunology and Microbiology

Topical Glaucoma Therapy Is Associated With Alterations of the Ocular Surface Microbiome Open Access

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Chih-Chiun J. Chang; Karina Somohano; Christine Zemsky; Anne-Catrin Uhlemann; Jeffrey Liebmann; George A. Cioffi; Lama A. Al-Aswad; Susan V. Lynch; Bryan J. Winn

Tags: eye, eyedrops, glaucoma, microbiome, ocular surfaces

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 32. doi:https://doi.org/10.1167/iovs.63.9.32

Low Vision

Binocularity Principles of PRL Development in Patients With Macular Disease Open Access

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Luminita Tarita-Nistor; Mark S. Mandelcorn

Tags: eye, fovea centralis, macular disorders, retina, outcome measures

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 19. doi:https://doi.org/10.1167/iovs.63.9.19

Multidisciplinary Ophthalmic Imaging

Subcellular Comparison of Visible-Light Optical Coherence Tomography and Electron Microscopy in the Mouse Outer Retina Open Access

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Pooja Chauhan; Aaron M. Kho; Paul FitzGerald; Bradley Shibata; Vivek J. Srinivasan

Tags: mice, optical coherence tomography, retina, visible light, embryonic lethal mutation

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 10. doi:https://doi.org/10.1167/iovs.63.9.10

Retina

Phenotypic Expression of CFH Rare Variants in Age-Related Macular Degeneration Patients in the Coimbra Eye Study Open Access

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Cláudia Farinha; Patrícia Barreto; Rita Coimbra; Adela Iutis; Maria Luz Cachulo; José Cunha-Vaz; Yara T. E. Lechanteur; Carel B. Hoyng; Rufino Silva

Tags: age-related macular degeneration, eye, phenotype, drusen, genes

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 5. doi:https://doi.org/10.1167/iovs.63.9.5

Longitudinal Evaluation of Changes in Retinal Architecture Using Optical Coherence Tomography in Achromatopsia Open Access

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Magdalini Triantafylla; Eleni Papageorgiou; Mervyn G. Thomas; Rebecca McLean; Susanne Kohl; Viral Sheth; Zhanhan Tu; Frank A. Proudlock; Irene Gottlob

Tags: achromatopsia, follow-up, optical coherence tomography, foveal hypoplasia, charcot-marie-tooth disease

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 6. doi:https://doi.org/10.1167/iovs.63.9.6

Branched Chain Amino Acids Promote ATP Production Via Translocation of Glucose Transporters Open Access

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Sachiko Iwai; Tomoko Hasegawa; Hanako Ohashi Ikeda; Akitaka Tsujikawa

Tags: amino acids, branched-chain, glucose transporter, translocation (genetics), glucose uptake, hela cells

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 7. doi:https://doi.org/10.1167/iovs.63.9.7

Correlation of Diabetic Disease Severity to Degree of Quadrant Asymmetry in En Face OCTA Metrics Open Access

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Jesse J. Jung; Shen Yi Lim; Xavier Chan; Srinivas R. Sadda; Quan V. Hoang

Tags: diabetes mellitus, diabetic retinopathy, eye, face, nonproliferative diabetic retinopathy

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 12. doi:https://doi.org/10.1167/iovs.63.9.12

Choriocapillaris Flow Imbalance in Fellow Eyes in Age-Related Macular Degeneration Open Access

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Narumi Harada; Norihiro Nagai; Yasuaki Mushiga; Yoko Ozawa

Tags: age-related macular degeneration, eye, fluid flow, imbalance

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 13. doi:https://doi.org/10.1167/iovs.63.9.13

Retinal Transcriptome and Cellular Landscape in Relation to the Progression of Diabetic Retinopathy Open Access

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Jiang-Hui Wang; Raymond C. B. Wong; Guei-Sheung Liu

Tags: diabetic retinopathy, genes, gender, cyclin d1, gene expression

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 26. doi:https://doi.org/10.1167/iovs.63.9.26

Correlation Between Hyperreflective Foci in the Choroid and Choroidal Discoloration in Vogt-Koyanagi-Harada Disease Open Access

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Young Ho Kim; Ariunaa Togloom; Jaeryung Oh

Tags: abnormal color, choroid, eye, face, pigmentation

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 27. doi:https://doi.org/10.1167/iovs.63.9.27

Quantification and Predictors of OCT-Based Macular Curvature and Dome-Shaped Configuration: Results From the UK Biobank Open Access

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Philipp L. Müller; Yuka Kihara; Abraham Olvera-Barrios; Alasdair N. Warwick; Catherine Egan; Katie M. Williams; Aaron Y. Lee; Adnan Tufail; for the UK Biobank Eyes and Vision Consortium

Tags: biobanks, cohort studies, eye, myopia, refractive errors

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 28. doi:https://doi.org/10.1167/iovs.63.9.28

Dependence of Retinal Pigment Epithelium Integrity on the NRF2–Heme Oxygenase-1 Axis Open Access

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Yida Jiang; Li-Juan Duan; Jingbo Pi; Yun-Zheng Le; Guo-Hua Fong

Tags: body tissue, heme, mice, oxidative stress, oxygenases

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 30. doi:https://doi.org/10.1167/iovs.63.9.30

Retinal Cell Biology

Ciliary Neurotrophic Factor Derived From Astrocytes Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK Pathways Open Access

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Kwanghyun Lee; Jin-Ok Choi; Ahreum Hwang; Hyoung Won Bae; Chan Yun Kim

Tags: 1-phosphatidylinositol 3-kinase, astrocytes, ciliary neurotrophic factor, mitogen-activated protein kinases, proto-oncogene proteins c-akt

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 4. doi:https://doi.org/10.1167/iovs.63.9.4

Sensitivity of the Dorsal-Central Retinal Pigment Epithelium to Sodium Iodate-Induced Damage Is Associated With Overlying M-Cone Photoreceptors in Mice Open Access

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Lili Lian; Yifan Zhai; Xuejiao Wan; Linxin Chen; Zuimeng Liu; Ruona Liu; Shijia Li; Jiajia Zhou; Yu Chen; Ling Hou; Huirong Li

Tags: mice, photoreceptors, retina, retinal cone, sodium

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 29. doi:https://doi.org/10.1167/iovs.63.9.29

Visual Psychophysics and Physiological Optics

Spatial and Temporal Integration Abnormalities in X-Linked Retinoschisis Open Access

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J. Jason McAnany; Jason C. Park; Gerald A. Fishman; Robert A. Hyde

Tags: fovea centralis, luminance, visual fields, x-linked retinoschisis

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 22. doi:https://doi.org/10.1167/iovs.63.9.22

Clinical Trials

Lateral Geniculate Nucleus Volume Determined on MRI Correlates With Corresponding Ganglion Cell Layer Loss in Acquired Human Postgeniculate Lesions Open Access

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Cyril Fabian Simmen; Fabienne Catherine Fierz; Lars Michels; Njoud Aldusary; Klara Landau; Marco Piccirelli; Ghislaine Lieselotte Traber

Tags: ganglia, lateral geniculate body, magnetic resonance imaging, volume

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 18. doi:https://doi.org/10.1167/iovs.63.9.18

Review

Hypolacrimia and Alacrimia as Diagnostic Features for Genetic or Congenital Conditions Open Access

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Marjolaine Willems; Constance F. Wells; Christine Coubes; Marie Pequignot; Alison Kuony; Frederic Michon

Tags: genes, genetics, nerve supply, proteins, syndrome

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 3. doi:https://doi.org/10.1167/iovs.63.9.3

Animal Models of Choroidal Neovascularization: A Systematic Review Open Access

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Bjørn K. Fabian-Jessing; Thomas Stax Jakobsen; Emilie Grarup Jensen; Sidsel Alsing; Silja Hansen; Lars Aagaard; Anne Louise Askou; Toke Bek; Thomas J. Corydon

Tags: animal model, choroidal neovascularization, systematic reviews, lasers

Investigative Ophthalmology & Visual Science August 2022, Vol.63, 11. doi:https://doi.org/10.1167/iovs.63.9.11

Erratum

Erratum in: Interleukin-19 Promotes Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy Open Access

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Investigative Ophthalmology & Visual Science August 2022, Vol.63, 23. doi:https://doi.org/10.1167/iovs.63.9.23

Erratum in: Multiple Invagination Patterns and Synaptic Efficacy in Primate and Mouse Rod Synaptic Terminals Open Access

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Investigative Ophthalmology & Visual Science August 2022, Vol.63, 33. doi:https://doi.org/10.1167/iovs.63.9.33

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