Volume 63 Issue 10 | IOVS

Biochemistry and Molecular Biology

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts Open Access

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Jiale Diao; Xinxin Chen; Pei Mou; Xiaoye Ma; Ruili Wei

Tags: berberine, fibroblasts, fibrosis, graves' ophthalmopathy, tissue remodeling

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 6. doi:https://doi.org/10.1167/iovs.63.10.6

RO4929097, a Selective γ-Secretase Inhibitor, Inhibits Subretinal Fibrosis Via Suppressing Notch and ERK1/2 Signaling in Laser-Induced Mouse Model Open Access

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Chaoyang Zhang; Shiyue Qin; Hai Xie; Qinghua Qiu; Haiyan Wang; Jingting Zhang; Dawei Luo; Jingfa Zhang

Tags: choroidal neovascularization, epithelial to mesenchymal transition, fibrosis, lasers, mice

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 14. doi:https://doi.org/10.1167/iovs.63.10.14

Clinical and Epidemiologic Research

Longitudinal Changes in Lens Thickness and Lens Power Among Persistent Non-Myopic and Myopic Children Open Access

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Xiaotong Han; Ruilin Xiong; Ling Jin; Qianyun Chen; Decai Wang; Shida Chen; Xiang Chen; Jason Ha; Yuting Li; Yabin Qu; Rong Lin; Mingguang He; Ian G. Morgan; Yangfa Zeng; Yizhi Liu

Tags: child, eye development, lens, crystalline, myopia, persistence

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 10. doi:https://doi.org/10.1167/iovs.63.10.10

The Effect of Multifocal Soft Contact Lens Wear on Axial and Peripheral Eye Elongation in the BLINK Study Open Access

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Donald O. Mutti; Loraine T. Sinnott; David A. Berntsen; Lisa A. Jones-Jordan; Danielle J. Orr; Jeffrey J. Walline; for the BLINK Study Group

Tags: contact lenses, contact lenses, hydrophilic, eye, meridians, vision

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 17. doi:https://doi.org/10.1167/iovs.63.10.17

Cornea

AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye Open Access

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Xin Zuo; Hao Zeng; Bowen Wang; Xue Yang; Dalian He; Li Wang; Hong Ouyang; Jin Yuan

Tags: corneal epithelial cells, dry eye syndromes, ferroptosis, stress

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 3. doi:https://doi.org/10.1167/iovs.63.10.3

SIRT1 Protects Against Particulate Matter-Induced Oxidative Stress in Human Corneal and Conjunctival Epithelial Cells Open Access

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Xiangzhe Li; Boram Kang; Youngsub Eom; Jingxiang Zhong; Hyung Keun Lee; Hyo Myung Kim; Jong Suk Song

Tags: apoptosis, cellular senescence, conjunctival epithelial cells, cornea, cytotoxicity

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 19. doi:https://doi.org/10.1167/iovs.63.10.19

METTL3 Attenuates Inflammation in Fusarium solani–Induced Keratitis via the PI3K/AKT Signaling Pathway Open Access

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Liwei Huang; Hanfeng Tang; Jianzhang Hu

Tags: 1-phosphatidylinositol 3-kinase, akt signaling pathway, cornea, inflammation, keratitis

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 20. doi:https://doi.org/10.1167/iovs.63.10.20

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Impaired Extraocular Muscle Innervation Is Present Before Eye Opening in a Mouse Model of Infantile Nystagmus Syndrome Open Access

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Sampath Kumar Vemula; Seoyoung A. Kim; Tapiwa Muvavarirwa; Jessica L. Bell; Mary C. Whitman

Tags: albinism, eye, mice, muscle of orbit, nerve supply

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 4. doi:https://doi.org/10.1167/iovs.63.10.4

Can Binocular Alignment Distinguish Hypertropia in Sagging Eye Syndrome From Superior Oblique Palsy? Open Access

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Qi Wei; Robert A. Clark; Joseph L. Demer

Tags: eye, fourth cranial nerve palsy, gaze, hypertropia, optical axis alignment

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 13. doi:https://doi.org/10.1167/iovs.63.10.13

Genetics

Comprehensive Genetic Analysis Unraveled the Missing Heritability in a Chinese Cohort With Wolfram Syndrome 1: Clinical and Genetic Findings Open Access

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Xin Zhang; Yue Xie; Ke Xu; Haoyu Chang; Xiaohui Zhang; Yang Li

Tags: chinese (other dialects), chinese people, cohort studies, genetic analysis, genetics

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 9. doi:https://doi.org/10.1167/iovs.63.10.9

Lens

Deficiency of Jamc Leads to Congenital Nuclear Cataract and Activates the Unfolded Protein Response in Mouse Lenses Open Access

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Jiani Li; Xuhua Tan; Qihang Sun; Xuri Li; Rongyuan Chen; Lixia Luo

Tags: cataract, cataract, nuclear, lens (device), lens, crystalline, mice

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.10.1

Physiology and Pharmacology

Subconjunctival Lymphatics Respond to VEGFC and Anti-Metabolites in Rabbit and Mouse Eyes Open Access

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Jong Yeon Lee; Jingyi Wu; Yameng Liu; Sindhu Saraswathy; Longfang Zhou; Qianwen Bu; Ying Su; Dongwon Choi; Eunkyung Park; Clemens A. Strohmaier; Robert N. Weinreb; Young-Kwon Hong; Xiaojing Pan; Alex S. Huang

Tags: eye, lymphatic vessels, metabolites, mice, oryctolagus cuniculus

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 16. doi:https://doi.org/10.1167/iovs.63.10.16

Retina

Pupillary Responses Reveal Autonomic Regulation Impairments in Patients With Central Serous Chorioretinopathy Open Access

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Xiaoyin Zhou; Hisashi Fukuyama; Yoichi Okita; Hiroyuki Kanda; Yuki Yamamoto; Takashi Araki; Fumi Gomi

Tags: autonomic nervous system, central serous chorioretinopathy, pupil light reflex, pupil reaction

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 2. doi:https://doi.org/10.1167/iovs.63.10.2

Loss of Fas Receptor Function Preserves Photoreceptor Structure and Function in Two Mouse Models of Inherited Retinal Degeneration Open Access

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Jingyu Yao; Tiantian Wang; Lin Jia; Yaoyan Qiu; David N. Zacks

Tags: cd95 antigens, mice, photoreceptors, retina, retinal degeneration

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 5. doi:https://doi.org/10.1167/iovs.63.10.5

UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair Open Access

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Ningda Xu; Yue Liu; Shanshan Nai; Yong Tao; Yuehe Ding; Lemei Jia; Qizhi Geng; Jie Li; Yujing Bai; Gong-Hong Wei; Meng-Qiu Dong; Linyi Luo; Mingwei Zhao; Xingzhi Xu; Xiao-Xin Li; Jing Li; Lvzhen Huang

Tags: antibodies, blue light, chromatin, double strand break repair, immunoprecipitation

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 7. doi:https://doi.org/10.1167/iovs.63.10.7

Short-Term Hyperuricemia Leads to Structural Retinal Changes That Can be Reversed by Serum Uric Acid Lowering Agents in Mice Open Access

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Hung-Liang Pai; Sophie Meng-Tien Hsieh; Yu-Shan Su; Xin-Yuan Sue; Han-Hsin Chang; David Pei-Cheng Lin

Tags: allopurinol, angiotensin ii, apoptosis, benzbromarone, gelatinase a

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 8. doi:https://doi.org/10.1167/iovs.63.10.8

Elongation of the Retina and Ciliary Body in Dependence of the Sagittal Eye Diameter Open Access

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Songhomitra Panda-Jonas; Gerd U. Auffarth; Jost B. Jonas; Rahul A. Jonas

Tags: ciliary body, eye, retina, optic disk

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 18. doi:https://doi.org/10.1167/iovs.63.10.18

Retinal Cell Biology

Timed Notch Inhibition Drives Photoreceptor Fate Specification in Human Retinal Organoids Open Access

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Shereen H. Chew; Cassandra Martinez; Kathleen R. Chirco; Sangeetha Kandoi; Deepak A. Lamba

Tags: organoids, photoreceptors

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 12. doi:https://doi.org/10.1167/iovs.63.10.12

Visual Psychophysics and Physiological Optics

Bi-directional Refractive Compensation for With-the-Rule and Against-the-Rule Astigmatism in Young Adults Open Access

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Kin-Ho Chan; Ho-Tin Shik; Kwan William Kwok; Chea-Su Kee; Tsz-Wing Leung

Tags: astigmatism, refractive errors, young adult, eye

Investigative Ophthalmology & Visual Science September 2022, Vol.63, 15. doi:https://doi.org/10.1167/iovs.63.10.15

Erratum

Erratum in: Functional Changes Within the Rod Inner Segment Ellipsoid in Wildtype Mice: An Optical Coherence Tomography and Electron Microscopy Study Open Access

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Investigative Ophthalmology & Visual Science September 2022, Vol.63, 11. doi:https://doi.org/10.1167/iovs.63.10.11

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