Volume 63 Issue 11 | IOVS

Anatomy and Pathology/Oncology

Enhanced Apoptosis in Choroidal Tissues in Lens-Induced Myopia Guinea Pigs by Activating the RASA1 Signaling Pathway Open Access

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Jinpeng Liu; Huixia Wei; Zhaohui Yang; Yixian Hao; Guimin Wang; Tuling Li; Ting Yu; Huiping Liao; Bo Bao; Qiuxin Wu; Hongsheng Bi; Dadong Guo

Tags: apoptosis, body tissue, caviidae, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 5. doi:https://doi.org/10.1167/iovs.63.11.5

Choroidal Thickness in Early Postnatal Guinea Pigs Predicts Subsequent Naturally Occurring and Form-Deprivation Myopia Open Access

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Liqin Jiang; Xinyu Liu; Lei Zhou; Joanna M. Fianza Busoy; Myo Thu Khine; Yee Shan Dan; Mengyuan Ke; Noel A. Brennan; Karen J. V. Catbagan; Leopold Schmetterer; Veluchamy A. Barathi; Quan V. Hoang

Tags: albinism, choroid, eye, myopia, refractive errors

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 10. doi:https://doi.org/10.1167/iovs.63.11.10

Elevated IGF-1 and GH Levels Are Correlated With a Thicker Iris and Wider Anterior Chamber Angle in Treatment-Naïve Acromegaly Patients Open Access

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Xia Zhang; Jin Ma; Lüe Li; Linyang Gan; Huijing He; Enhua Shao; Xiaopeng Guo; Huijuan Zhu; Hui You; Yong Zhong; Bing Xing

Tags: acromegaly, anterior chamber of eye, insulin-like growth factor i, iris

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 27. doi:https://doi.org/10.1167/iovs.63.11.27

Biochemistry and Molecular Biology

Spleen Tyrosine Kinase Contributes to Müller Glial Expression of Proangiogenic Cytokines in Diabetes Open Access

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Esma I. Yerlikaya; Allyson L. Toro; Siddharth Sunilkumar; Ashley M. VanCleave; Ming Leung; Yuka Imamura Kawasawa; Scot R. Kimball; Michael D. Dennis

Tags: cytokine, diabetes mellitus, diabetes mellitus, type 2, syk kinase, vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 25. doi:https://doi.org/10.1167/iovs.63.11.25

Cornea

Inhibition of the m6A Methyltransferase METTL3 Attenuates the Inflammatory Response in Fusarium solani-Induced Keratitis via the NF-κB Signaling Pathway Open Access

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Hanfeng Tang; Liwei Huang; Jianzhang Hu

Tags: acute erythroblastic leukemia, cornea, fungal keratitis, fusarium solani, inflammation

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 2. doi:https://doi.org/10.1167/iovs.63.11.2

TGF-β–Mediated Modulation of Cell–Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells Open Access

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Kim Santerre; Sergio Cortez Ghio; Stéphanie Proulx

Tags: chronic exertional compartment syndrome, cornea, endothelial cells

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 3. doi:https://doi.org/10.1167/iovs.63.11.3

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Eye Movements But Not Vision Drive the Development of Palisade Endings Open Access

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Genova Carrero-Rojas; Paula M. Calvo; Thomas Lischka; Johannes Streicher; Rosa R. de la Cruz; Angel M. Pastor; Roland Blumer

Tags: eye, eye movement, incobotulinumtoxina, inferior rectus muscle, injections

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 15. doi:https://doi.org/10.1167/iovs.63.11.15

Glaucoma

Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance Open Access

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Emmi Kapiainen; Harri Elamaa; Ilkka Miinalainen; Valerio Izzi; Lauri Eklund

Tags: angiopoietins, mice, schlemm's canal, glaucoma, intraocular pressure

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.11.1

Optic Nerve Head Myelin-Related Protein, GFAP, and Iba1 Alterations in Non-Human Primates With Early to Moderate Experimental Glaucoma Open Access

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Priya Chaudhary; Cheri Stowell; Juan Reynaud; Stuart K. Gardiner; Hongli Yang; Galen Williams; Imee Williams; Nicholas Marsh-Armstrong; Claude F. Burgoyne

Tags: eye, glaucoma, glial fibrillary acidic protein, myelin, optic disk

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 9. doi:https://doi.org/10.1167/iovs.63.11.9

Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues Open Access

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Alireza Karimi; Reza Razaghi; Seyed Mohammadali Rahmati; Christopher A. Girkin; J. Crawford Downs

Tags: biomechanics, cerebrospinal fluid pressure, cribriform plate, donors, eye

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 14. doi:https://doi.org/10.1167/iovs.63.11.14

Quantitative Microstructural Analysis of Cellular and Tissue Remodeling in Human Glaucoma Optic Nerve Head Open Access

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Carolyn Guan; Mary Ellen Pease; Sarah Quillen; Yik Tung Tracy Ling; Ximin Li; Elizabeth Kimball; Thomas V. Johnson; Thao D. Nguyen; Harry A. Quigley

Tags: eye, glaucoma, optic disk, optic nerve

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 18. doi:https://doi.org/10.1167/iovs.63.11.18

The Association Between Age and Systemic Variables and the Longitudinal Trend of Intraocular Pressure in a Large-Scale Health Examination Cohort Open Access

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Ryo Asaoka; Akira Obana; Hiroshi Murata; Yuri Fujino; Takashi Omoto; Shuichiro Aoki; Shigetaka Muto; Yuji Takayanagi; Tatsuya Inoue; Masaki Tanito

Tags: cohort studies, health, intraocular pressure, trend

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 22. doi:https://doi.org/10.1167/iovs.63.11.22

Retina

The Fovea-Protective Impact of Double-Layer Sign in Eyes With Foveal-Sparing Geographic Atrophy and Age-Related Macular Degeneration Open Access

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Hisashi Fukuyama; Bonnie Bertha Huang; Ghazi BouGhanem; Amani A. Fawzi

Tags: age-related macular degeneration, atrophy, eye, fovea centralis, photon correlation spectroscopy

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 4. doi:https://doi.org/10.1167/iovs.63.11.4

Hypoxia-Inducible Factor-1α in Rods Is Neuroprotective Following Retinal Detachment Open Access

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Bing X. Ross; Lin Jia; Dejuan Kong; Tiantian Wang; Jingyu Yao; Heather M. Hager; Steven F. Abcouwer; David N. Zacks

Tags: hypoxia, mice, retinal detachment, rod photoreceptors, retina

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 7. doi:https://doi.org/10.1167/iovs.63.11.7

Reticular Pseudodrusen Are Associated With More Advanced Para-Central Photoreceptor Degeneration in Intermediate Age-Related Macular Degeneration Open Access

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Matt Trinh; Natalie Eshow; David Alonso-Caneiro; Michael Kalloniatis; Lisa Nivison-Smith

Tags: age-related macular degeneration, eye, photoreceptors, reticular pseudodrusen, tissue degeneration

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 12. doi:https://doi.org/10.1167/iovs.63.11.12

Association of Retinal Sensitivity With Optical Coherence Tomography Microstructure in Highly Myopic Patients Open Access

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Un Chul Park; Chang Ki Yoon; Kunho Bae; Eun Kyoung Lee

Tags: macular disorders, myopia, optical coherence tomography, eye, retinoschisis

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 13. doi:https://doi.org/10.1167/iovs.63.11.13

Preferential Loss of Contrast Decrement Responses in Human Glaucoma Open Access

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Anthony M. Norcia; Alexandra Yakovleva; Naz Jehangir; Jeffrey L. Goldberg

Tags: glaucoma

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 16. doi:https://doi.org/10.1167/iovs.63.11.16

MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in Vascular Endothelial Cells Open Access

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Yamei Cui; Ruyuan Liu; Yiwen Hong; Yishen Wang; Yanjie Zhu; Tao Wen; Jing Lu; Shudi Mao; Xiao Wang; Jianying Pan; Yan Luo

Tags: angiogenesis, endothelial cells, mice, micrornas, retina

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 19. doi:https://doi.org/10.1167/iovs.63.11.19

Foveal Cone Structure in Patients With Blue Cone Monochromacy Open Access

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Emily J. Patterson; Angelos Kalitzeos; Thomas M. Kane; Navjit Singh; Joseph Kreis; Mark E. Pennesi; Alison J. Hardcastle; Jay Neitz; Maureen Neitz; Michel Michaelides; Joseph Carroll

Tags: retinal cone

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 23. doi:https://doi.org/10.1167/iovs.63.11.23

Relationship Between Drusen Height and OCT Biomarkers of Atrophy in Non-Neovascular AMD Open Access

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Adrian Au; Ahmad Santina; Neda Abraham; Miri Fogel Levin; Giulia Corradetti; SriniVas Sadda; David Sarraf

Tags: atrophy, biological markers, drusen, eye

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 24. doi:https://doi.org/10.1167/iovs.63.11.24

Bioinformatics Analysis and Experimental Identification of Immune-Related Genes and Immune Cells in the Progression of Retinoblastoma Open Access

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Shuilian Chen; Xi Chen; Ping Zhang; Shuxia Chen; Xiao Wang; Qian Luo; Zedu Cui; Yuke Huang; Linxi Wan; Xiangtao Hou; Huan Yao; Xuan Liu; Anqi He; Zihua Jiang; Jin Qiu; Yan Li; Keming Yu; Jing Zhuang

Tags: bioinformatics, genes, retinoblastoma, neoplasms

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 28. doi:https://doi.org/10.1167/iovs.63.11.28

Retinal Cell Biology

Targeted Expression of Retinoschisin by Retinal Bipolar Cells in XLRS Promotes Resolution of Retinoschisis Cysts Sans RS1 From Photoreceptors Open Access

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Camasamudram Vijayasarathy; Yong Zeng; Dario Marangoni; Lijin Dong; Zhuo-Hua Pan; Elizabeth M. Simpson; Robert N. Fariss; Paul A. Sieving

Tags: cysts, mice, photoreceptors, retina, retinal bipolar cells

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 8. doi:https://doi.org/10.1167/iovs.63.11.8

Retinal Cone Mosaic in sws1-Mutant Medaka (Oryzias latipes), A Teleost Open Access

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Megumi Matsuo; Makoto Matsuyama; Tomoe Kobayashi; Shinji Kanda; Satoshi Ansai; Taichi Kawakami; Erika Hosokawa; Yutaka Daido; Takehiro G. Kusakabe; Kiyoshi Naruse; Shoji Fukamachi

Tags: antibodies, mosaicism, retina, retinal cone, oryzias

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 21. doi:https://doi.org/10.1167/iovs.63.11.21

Visual Psychophysics and Physiological Optics

Suprathreshold Contrast Perception Is Altered by Long-term Adaptation to Habitual Optical Blur Open Access

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Cherlyn J. Ng; Ramkumar Sabesan; Antoine Barbot; Martin S. Banks; Geunyoung Yoon

Tags: optics, perception, keratoconus, spatial frequency

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 6. doi:https://doi.org/10.1167/iovs.63.11.6

Seasonal Variation in Diurnal Rhythms of the Human Eye: Implications for Continuing Ocular Growth in Adolescents and Young Adults Open Access

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Nickolai G. Nilsen; Stuart J. Gilson; Hilde R. Pedersen; Lene A. Hagen; Kenneth Knoblauch; Rigmor C. Baraas

Tags: adolescent, circadian rhythms, eye, seasonal variation, young adult

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 20. doi:https://doi.org/10.1167/iovs.63.11.20

Visual Axis and Stiles–Crawford Effect Peak Show a Positional Correlation in Normal Eyes: A Cohort Study Open Access

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Seung Pil Bang; Jiakai Lyu; Cherlyn J. Ng; Geunyoung Yoon

Tags: cohort studies, eye, pupil, optics

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 26. doi:https://doi.org/10.1167/iovs.63.11.26

Review

Implications of Neural Plasticity in Retinal Prosthesis Open Access

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Daniel Caravaca-Rodriguez; Susana P. Gaytan; Gregg J. Suaning; Alejandro Barriga-Rivera

Tags: brain, neuronal plasticity, retina, retinal degeneration, vision

Investigative Ophthalmology & Visual Science October 2022, Vol.63, 11. doi:https://doi.org/10.1167/iovs.63.11.11

Erratum

Erratum in: An Insertion Variant in CRH Confers an Increased Risk of Central Serous Chorioretinopathy Open Access

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Investigative Ophthalmology & Visual Science October 2022, Vol.63, 17. doi:https://doi.org/10.1167/iovs.63.11.17

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