Volume 63 Issue 12 | IOVS

Anatomy and Pathology/Oncology

Formation and Fixation of the Annulus of Zinn and Relation With Extraocular Muscles: A Plastinated Histologic Study and Its Clinical Significance Open Access

PDF

Chunjing Ma; Xingyu Zhu; Xuan Chu; Liu Xu; Wei Zhang; Shengchun Xu; Liang Liang

Tags: muscle of orbit, optics, orbital complex of bones - apex, endoscopy, anulus tendineus communis

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 16. doi:https://doi.org/10.1167/iovs.63.12.16

Biochemistry and Molecular Biology

Combination of AIBP, apoA-I, and Aflibercept Overcomes Anti-VEGF Resistance in Neovascular AMD by Inhibiting Arteriolar Choroidal Neovascularization Open Access

PDF

Zhao Zhang; Megan M. Shen; Yingbin Fu

Tags: anti-vascular endothelial growth factor therapy, choroidal neovascularization, mice, aflibercept, apolipoprotein a-i

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 2. doi:https://doi.org/10.1167/iovs.63.12.2

Sirt1 Regulates Corneal Epithelial Migration by Deacetylating Cortactin Open Access

PDF

Yong Lin; Qi Liu; Li Li; Rusen Yang; Juxiu Ye; Shuai Yang; Guangying Luo; Peter S. Reinach; Dongsheng Yan

Tags: cornea, epithelium, mice, proteins

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 14. doi:https://doi.org/10.1167/iovs.63.12.14

An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration Open Access

PDF

Robyn M. Biggs; Elisavet Makou; Scott Lauder; Andrew P. Herbert; Paul N. Barlow; Suresh K. Katti

Tags: age-related macular degeneration, complement factor h, complement system proteins, hemolysis, proteins

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 30. doi:https://doi.org/10.1167/iovs.63.12.30

Clinical and Epidemiologic Research

Potential for Collider Bias in Studies Examining the Association of Central Corneal Thickness With Glaucoma Open Access

PDF

Anthony P. Khawaja; Nomdo M. Jansonius

Tags: cornea, glaucoma, intraocular pressure

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 3. doi:https://doi.org/10.1167/iovs.63.12.3

Vision With Retrodots and Factors for Declining Visual Function Open Access

PDF

Natsuko Hatsusaka; Naoki Tanimura; Mai Yamazaki; Norihiro Mita; Yuki Ukai; Yusuke Seki; Hisanori Miyashita; Tsuyoshi Mito; Eri Kubo; Hiroshi Sasaki

Tags: cataract, eye, respiratory distress syndrome, newborn, vision, developmental venous anomaly, cerebral

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 17. doi:https://doi.org/10.1167/iovs.63.12.17

Prevalence and Ocular Biometric Characteristics of Myopia in Primary Angle Closure Disease in Rural China: The Handan Eye Study Open Access

PDF

Yuanbo Liang; Ruyue Shen; Weihe Zhou; Sujie Fan; Poemen P. Chan; Clement C. Y. Tham; Nathan Congdon; David S. Friedman; Ningli Wang

Tags: biometry, china, eye, myopia, prevalence

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 19. doi:https://doi.org/10.1167/iovs.63.12.19

Vascular Changes of the Choroid and Their Correlations With Visual Acuity in Pathological Myopia Open Access

PDF

Yiyi Wang; Sisi Chen; Jue Lin; Wen Chen; Huimin Huang; Xin Fan; Xinyuan Cao; Meixiao Shen; Jie Ye; Shuangqian Zhu; Anquan Xue; Fan Lu; Yilei Shao

Tags: choroid, cortical blindness, myopia, visual acuity, eye

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 20. doi:https://doi.org/10.1167/iovs.63.12.20

Papillary and Peripapillary Hemorrhages in Eyes With Pathologic Myopia Open Access

PDF

Jianping Xiong; Ran Du; Shiqi Xie; Hongshuang Lu; Changyu Chen; Tae lgarashi-Yokoi; Kengo Uramoto; Yuka Onishi; Takeshi Yoshida; Koju Kamoi; Kyoko Ohno-Matsui

Tags: eye, hemorrhage, myopic macular degeneration, glaucoma, recurrence

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 28. doi:https://doi.org/10.1167/iovs.63.12.28

Cornea

Gallic Acid Ameliorates Aspergillus Fumigatus Keratitis Through Reducing Fungal Load and Suppressing the Inflammatory Response Open Access

PDF

Songying Luan; Xudong Peng; Jing Lin; Yingxue Zhang; Lu Zhan; Jiao Yin; Junjie Luan; Xiaoyue Ji; Guiqiu Zhao

Tags: aspergillus fumigatus, gallic acid, inflammation, inflammatory response, keratitis

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 12. doi:https://doi.org/10.1167/iovs.63.12.12

Conjunctiva Resident γδ T Cells Expressed High Level of IL-17A and Promoted the Severity of Dry Eye Open Access

PDF

Ling Li; Yanxiao Li; Xinhao Zhu; Biao Wu; Zhuo Tang; Han Wen; Jianshu Yuan; Qinxiang Zheng; Wei Chen

Tags: conjunctiva, dry eye syndromes, interleukin-17, mice, t-lymphocytes

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 13. doi:https://doi.org/10.1167/iovs.63.12.13

AMPK/MFF Activation: Role in Mitochondrial Fission and Mitophagy in Dry Eye Open Access

PDF

Fangli Peng; Dan Jiang; Wei Xu; Yining Sun; Zhiwei Zha; Xiying Tan; Jinjie Yu; Chengjie Pan; Qinxiang Zheng; Wei Chen

Tags: ampk, dry eye syndromes, mitochondria

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 18. doi:https://doi.org/10.1167/iovs.63.12.18

Multiple Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XII Open Access

PDF

Achuth Nair; Yogeshwari S. Ambekar; Christian Zevallos-Delgado; Taye Mekonnen; Mei Sun; Fernando Zvietcovich; Manmohan Singh; Salavat Aglyamov; Manuel Koch; Giuliano Scarcelli; Edgar M. Espana; Kirill V. Larin

Tags: collagen, cornea, elasticity imaging techniques, optics, regulation

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 24. doi:https://doi.org/10.1167/iovs.63.12.24

Type 2 Diabetes Mellitus Makes Corneal Endothelial Cells Vulnerable to Ultraviolet A-Induced Oxidative Damage Via Decreased DJ-1/Nrf2/NQO1 Pathway Open Access

PDF

Xueling Zhang; Jini Qiu; Feifei Huang; Kun Shan; Chaoran Zhang

Tags: chronic exertional compartment syndrome, cornea, diabetes mellitus, type 2, endothelial cells, ultraviolet a radiation

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 25. doi:https://doi.org/10.1167/iovs.63.12.25

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Microstimulation of Interstitial Nucleus of Cajal Evokes Directionally Disconjugate Eye Movements in Monkeys With Pattern Strabismus Open Access

PDF

Adam Pallus; Mark M. G. Walton

Tags: cercopithecidae, eye, eye movement, strabismus, interstitial nucleus of cajal

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 6. doi:https://doi.org/10.1167/iovs.63.12.6

Temporal Eye–Hand Coordination During Visually Guided Reaching in 7- to 12-Year-Old Children With Strabismus Open Access

PDF

Krista R. Kelly; Dorsa Mir Norouzi; Mina Nouredanesh; Reed M. Jost; Christina S. Cheng-Patel; Cynthia L. Beauchamp; Lori M. Dao; Becky A. Luu; David R. Stager, Jr; James Y. Tung; Ewa Niechwiej-Szwedo

Tags: child, eye-hand coordination, saccades, strabismus, kinematics

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 10. doi:https://doi.org/10.1167/iovs.63.12.10

Genetics

Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure Open Access

PDF

Elangovan Boobalan; Amy H. Thompson; Ramakrishna P. Alur; David M. McGaughey; Lijin Dong; Grace Shih; Emile R. Vieta-Ferrer; Ighovie F. Onojafe; Vijay K. Kalaskar; Gavin Arno; Andrew J. Lotery; Bin Guan; Chelsea Bender; Omar Memon; Lauren Brinster; Clement Soleilhavoup; Lia Panman; Tudor C. Badea; Andrea Minella; Antonio Jacobo Lopez; Sara M. Thomasy; Ala Moshiri; Delphine Blain; Robert B. Hufnagel; Tiziana Cogliati; Kapil Bharti; Brian P. Brooks

Tags: embryo, fissure, mice, optics, eye

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 5. doi:https://doi.org/10.1167/iovs.63.12.5

miR-328-3p Affects Axial Length Via Multiple Routes and Anti-miR-328-3p Possesses a Potential to Control Myopia Progression Open Access

PDF

Chung-Ling Liang; Ku-Chung Chen; Edward Hsi; Jui-Yu Lin; Chien-Yuan Chen; Jung-Kai Tseng; Suh-Hang H. Juo

Tags: mice, myopia, oryctolagus cuniculus, eye, toxic effect

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 11. doi:https://doi.org/10.1167/iovs.63.12.11

Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy Open Access

PDF

Huijing Ye; Anqi Sun; Wei Xiao; Te Zhang; Zhihui Xu; Lu Shi; Xiaotong Sha; Huasheng Yang

Tags: circular rna, rna, messenger, graves' ophthalmopathy, connective tissue, genes

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 27. doi:https://doi.org/10.1167/iovs.63.12.27

Glaucoma

Pregabalin Mediates Retinal Ganglion Cell Survival From Retinal Ischemia/Reperfusion Injury Via the Akt/GSK3β/β-Catenin Signaling Pathway Open Access

PDF

Jing Xu; Yuyan Guo; Qiong Liu; Hui Yang; Ming Ma; Jian Yu; Linjiang Chen; Chunlian Ou; Xiaohui Liu; Jing Wu

Tags: pregabalin, proto-oncogene proteins c-akt, retinal ischemia, wounds and injuries, signal pathway

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 7. doi:https://doi.org/10.1167/iovs.63.12.7

Birefringent Properties of the Peripapillary Retinal Nerve Fiber Layer in Healthy and Glaucoma Subjects Analyzed by Polarization-Sensitive OCT Open Access

PDF

Stefan Steiner; Florian Schwarzhans; Sylvia Desissaire; Hemma Resch; Georg Fischer; Michael Pircher; Christoph K. Hitzenberger; Clemens Vass

Tags: eye, glaucoma, retinal nerve fiber layer, birefringence

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 8. doi:https://doi.org/10.1167/iovs.63.12.8

YAP/TAZ Mediate TGFβ2-Induced Schlemm's Canal Cell Dysfunction Open Access

PDF

Haiyan Li; Ayushi Singh; Kristin M. Perkumas; W. Daniel Stamer; Preethi S. Ganapathy; Samuel Herberg

Tags: actins, cytoskeleton, hydrogel, hydrogels, pathophysiology

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 15. doi:https://doi.org/10.1167/iovs.63.12.15

Low Vision

Optic Flow Processing in Patients With Macular Degeneration Open Access

PDF

Jade Guénot; Yves Trotter; Paul Fricker; Marta Cherubini; Vincent Soler; Benoit R. Cottereau

Tags: macular degeneration, motion, optic flow, scotoma

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 21. doi:https://doi.org/10.1167/iovs.63.12.21

Retina

Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography Open Access

PDF

Zhichao Wu; Xiao Zhou; Zhongdi Chu; Giovanni Gregori; Ruikang K. Wang; Philip J. Rosenfeld; Robyn H. Guymer

Tags: angiogram, chief complaint, choroid, drusen, eye

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.12.1

Clinical Relevance of Parafoveal Intercapillary Spaces and Foveal Avascular Zone in Diabetic Retinopathy Without Macular Edema Open Access

PDF

Noriko Terada; Tomoaki Murakami; Kenji Ishihara; Yoko Dodo; Keiichi Nishikawa; Kentaro Kawai; Akitaka Tsujikawa

Tags: diabetic retinopathy, eye, macular edema, parafoveal region, diabetes mellitus

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 4. doi:https://doi.org/10.1167/iovs.63.12.4

Single-Cell Transcriptomic Profiling of Human Retinal Organoids Revealed a Role of IGF1-PHLDA1 Axis in Photoreceptor Precursor Specification Open Access

PDF

Yuhua Xiao; Xiying Mao; Xing Hu; Songtao Yuan; Xu Chen; Wangxuan Dai; Shuyao Zhang; Yonghua Li; Mingkang Chen; Peiyao Mao; Yizhi Liu; Qinghuai Liu; Youjin Hu

Tags: insulin-like growth factor i, organoids, photoreceptors, rna, small cytoplasmic, genes

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 9. doi:https://doi.org/10.1167/iovs.63.12.9

Retinal Vascular Plexuses Are Unequally Affected in Canine Inherited Retinal Degenerations Open Access

PDF

Ana Ripolles-Garcia; Yineng Chen; Yu Sato; Alexa Gray; Gui-Shuang Ying; Gustavo D. Aguirre; William A. Beltran

Tags: retinal degeneration, retinal vasculature, dog, domestic, retinitis pigmentosa, diagnostic imaging

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 22. doi:https://doi.org/10.1167/iovs.63.12.22

Decreased Levels of Erythrocyte Membrane Arachidonic and Docosahexaenoic Acids Are Associated With Retinopathy of Prematurity Open Access

PDF

Tessa C. Gillespie; Esther S. Kim; Tristan Grogan; Irena Tsui; Alison Chu; Kara L. Calkins

Tags: docosahexaenoic acids, erythrocyte membrane, fatty acids, infant, polyunsaturated fatty acids

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 23. doi:https://doi.org/10.1167/iovs.63.12.23

Retinal Cell Biology

Protrusion of KCNJ13 Gene Knockout Retinal Pigment Epithelium Due to Oxidative Stress–Induced Cell Death Open Access

PDF

Yuki Kanzaki; Hirofumi Fujita; Keita Sato; Mio Hosokawa; Hiroshi Matsumae; Yuki Morizane; Hideyo Ohuchi

Tags: cell death, gene knockout techniques, oxidative stress, retinal pigment epithelium, retinal pigment cell

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 29. doi:https://doi.org/10.1167/iovs.63.12.29

Visual Psychophysics and Physiological Optics

The Stereoscopic Anisotropy Is Smaller in Elderly Population Open Access

PDF

Aracelis Aguilera-Francisco; Ignacio Serrano-Pedraza

Tags: anisotropy, health disparity, older adult

Investigative Ophthalmology & Visual Science November 2022, Vol.63, 26. doi:https://doi.org/10.1167/iovs.63.12.26

This feature is available to authenticated users only.

To View More...

You must be signed into an individual account to use this feature.