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Anatomy and Pathology/Oncology

Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia Open Access
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Dillon M. Brown; Michael A. Kowalski; Quinn M. Paulus; Jianshi Yu; Praveen Kumar; Maureen A. Kane; Jay M. Patel; C. Ross Ethier; Machelle T. Pardue
Tags: biomechanics, mice, myopia, sclera, eye
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 13. doi:https://doi.org/10.1167/iovs.63.13.13
Preclinical Evaluation of Trabectedin in Combination With Targeted Inhibitors for Treatment of Metastatic Uveal Melanoma Open Access
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Kseniya Glinkina; Fariba Nemati; Amina F. A. S. Teunisse; Maria Chiara Gelmi; Vesnie Etienne; Muriel J. Kuipers; Samar Alsafadi; Martine J. Jager; Didier Decaudin; Aart G. Jochemsen
Tags: foretinib, trabectedin, uveal melanoma, cell lines
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 14. doi:https://doi.org/10.1167/iovs.63.13.14
Detectability of Plasma-Derived Circulating Tumor DNA Panel in Patients Undergoing Primary Treatment for Uveal Melanoma Open Access
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Jasmine H. Francis; Christopher A. Barker; A. Rose Brannon; Julia Canestraro; Melissa Robbins; Christina E. Swartzwelder; Sara Levine; Crystal Law; Michael F. Berger; Alexander Shoushtari; David H. Abramson
Tags: circulating tumor dna, plasma, uveal melanoma
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 17. doi:https://doi.org/10.1167/iovs.63.13.17

Clinical and Epidemiologic Research

Association Between Oral Metformin Use and the Development of Age-Related Macular Degeneration in Diabetic Patients: A Systematic Review and Meta-Analysis Open Access
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Kai-Hsiang Liang; Chih-Hao Chen; Hou-Ren Tsai; Chun-Yu Chang; Tai-Li Chen; Wei-Cherng Hsu
Tags: age-related macular degeneration, diabetes mellitus, meta-analysis, metformin, systematic reviews
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 10. doi:https://doi.org/10.1167/iovs.63.13.10
Contrast Sensitivity Function: A More Sensitive Index for Assessing Protective Effects of the Cilioretinal Artery on Macular Function in High Myopia Open Access
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Ling Wei; Jiaqi Meng; Kaiwen Cheng; Wenwen He; Jiao Qi; Zhong-Lin Lu; Yi Lu; Xiangjia Zhu
Tags: cilioretinal artery, contrast sensitivity, eye, macular function, myopia
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 25. doi:https://doi.org/10.1167/iovs.63.13.25

Cornea

Insufficient Dose of ERCC8 Protein Caused by a Frameshift Mutation Is Associated With Keratoconus With Congenital Cataracts Open Access
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Xiao-Dan Hao; Yi-Zhi Yao; Kai-Ge Xu; Bin Dong; Wen-Hua Xu; Jing-Jing Zhang
Tags: congenital cataract, proteins, keratoconus, frameshift mutation function
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.13.1
Hyaluronan Modulates the Biomechanical Properties of the Cornea Open Access
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Xiao Lin; Taye Mekonnen; Sudhir Verma; Christian Zevallos-Delgado; Manmohan Singh; Salavat R. Aglyamov; Tarsis F. Gesteira; Kirill V. Larin; Vivien J. Coulson-Thomas
Tags: cornea, hyaluronan, mice
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 6. doi:https://doi.org/10.1167/iovs.63.13.6
The Matricellular Protein SPARC Decreases in the Lacrimal Gland At Adulthood and During Inflammation Open Access
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Jessica Feldt; Angela Garriz; Maria C. Rodriguez Benavente; Ashley M. Woodward; Driss Zoukhri; Pablo Argüeso
Tags: adult, inflammation, lacrimal gland, proteins, sparc study
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 8. doi:https://doi.org/10.1167/iovs.63.13.8
Different Murine High-Risk Corneal Transplant Settings Vary Significantly in Their (Lymph)angiogenic and Inflammatory Cell Signatures Open Access
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Wei Zhang; Alfrun Schönberg; Fiona Bassett; Karina Hadrian; Deniz Hos; Martina Becker; Felix Bock; Claus Cursiefen
Tags: cornea, keratoplasty, wounds and injuries, mice, angiogenesis
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 18. doi:https://doi.org/10.1167/iovs.63.13.18

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Children With Amblyopia Make More Saccadic Fixations When Doing the Visual Search Task Open Access
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Krishnaveni Nagarajan; Gang Luo; Monika Narasimhan; PremNandhini Satgunam
Tags: amblyopia, child, visual search, eye
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 27. doi:https://doi.org/10.1167/iovs.63.13.27

Genetics

Overexpression of Rhodopsin or Its Mutants Leads to Energy Metabolism Dysfunction in 661w Cells Open Access
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Yang Liu; Xin Wang; Ruowen Gong; Gezhi Xu; Min Zhu
Tags: cell injury, energy metabolism, mitochondria, pathophysiology, protein overexpression
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 2. doi:https://doi.org/10.1167/iovs.63.13.2
Inverse Association of APOE ε4 and Glaucoma Modified by Systemic Hypertension: The Canadian Longitudinal Study on Aging Open Access
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Ellen E. Freeman; Joseph Bastasic; Alyssa Grant; Gareth Leung; Gisele Li; Ralf Buhrmann; Marie-Hélène Roy-Gagnon
Tags: aging, apolipoprotein e, glaucoma, hypertension, longitudinal studies
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 9. doi:https://doi.org/10.1167/iovs.63.13.9

Glaucoma

Blood Pressure Measures and Incident Primary Open-Angle Glaucoma Open Access
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Carmelo Macri; Christopher X. Wong; Samuel J. Tu; Robert Casson; Kuldev Singh; Sophia Y. Wang; Michelle T. Sun
Tags: blood pressure, open-angle glaucoma
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 3. doi:https://doi.org/10.1167/iovs.63.13.3
Intracameral Injection of AAV-DJ.COMP-ANG1 Reduces the IOP of Mice by Reshaping the Trabecular Outflow Pathway Open Access
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Yunsheng Qiao; Zhongmou Sun; Chen Tan; Junyi Lai; Xinghuai Sun; Junyi Chen
Tags: angiotensin i, injections, intraocular pressure, mice, eye
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 15. doi:https://doi.org/10.1167/iovs.63.13.15
Novel Discoveries of the Relationship Between the Vitreous Zonule and the Anterior Segment Characteristics in Eyes With Primary Angle-Closure Disease Open Access
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Kun Lv; Zhiqiao Liang; Kangyi Yang; Xuanzhu Chen; Yao Ma; Huijuan Wu
Tags: eye, phased thoracic-abdominal compression-decompression, ultrasound biomicroscopy, vitreous body, anterior chamber of eye
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 16. doi:https://doi.org/10.1167/iovs.63.13.16

Immunology and Microbiology

Microbiological Characteristics of Ocular Surface Associated With Dry Eye in Children and Adolescents With Diabetes Mellitus Open Access
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Zhangling Chen; Yan Jia; Ying Xiao; Qiurong Lin; Yu Qian; Zhaoyu Xiang; Lipu Cui; Xinran Qin; Shuli Chen; Chenhao Yang; Haidong Zou
Tags: adolescent, child, diabetes mellitus, dry eye syndromes, ocular surfaces
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 20. doi:https://doi.org/10.1167/iovs.63.13.20
Role of Oncostatin M in the Pathogenesis of Vernal Keratoconjunctivitis: Focus on the Barrier Function of the Epithelium and Interleukin-33 Production by Fibroblasts Open Access
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Ishin Ninomiya; Kenji Yamatoya; Keitaro Mashimo; Akira Matsuda; Ayumi Usui-Ouchi; Yoshihiko Araki; Nobuyuki Ebihara
Tags: e-cadherin, epithelium, fibroblasts, interleukin-33, keratoconjunctivitis, vernal
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 26. doi:https://doi.org/10.1167/iovs.63.13.26
Type I Interferon Signaling Is Critical During the Innate Immune Response to HSV-1 Retinal Infection Open Access
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Shan Fan; Jae Hyuk Yoo; Garam Park; Steven Yeh; Christopher D. Conrady
Tags: body tissue, human herpesvirus 1, immune response, infections, interferon type i
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 28. doi:https://doi.org/10.1167/iovs.63.13.28

Retina

Deep Capillary Plexus Features in Acute Macular Neuroretinopathy: Novel Insights Based on the Anatomy of Henle Fiber Layer Open Access
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Diogo Cabral; Prithvi Ramtohul; Luca Zatreanu; Daniel Galhoz; Miguel Leitao; Vanda Nogueira; David Sarraf; K. Bailey Freund
Tags: acute macular neuroretinopathy, blood capillaries, venule, fluid flow
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 4. doi:https://doi.org/10.1167/iovs.63.13.4
Vasomotion in Retinal Arterioles Is Modified by Exercise and Flicker Stimulation Open Access
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Line Petersen; Christian Aalkjaer; Toke Bek
Tags: arteriole, exercise, photopsia, vasomotion
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 7. doi:https://doi.org/10.1167/iovs.63.13.7
Photoreceptor Function and Structure in Autosomal Dominant Vitelliform Macular Dystrophy Caused by BEST1 Mutations Open Access
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Artur V. Cideciyan; Samuel G. Jacobson; Malgorzata Swider; Alexander Sumaroka; Rebecca Sheplock; Arun K. Krishnan; Alexandra V. Garafalo; Karina E. Guziewicz; Gustavo D. Aguirre; William A. Beltran; Elise Heon
Tags: best1 gene, eye, mutation, photoreceptors, retina
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 12. doi:https://doi.org/10.1167/iovs.63.13.12
Rapamycin Inhibits Light-Induced Necrosome Activation Occurring in Wild-Type, but not RPE65-Null, Mouse Retina Open Access
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Chunfeng Lu; Songhua Li; Minghao Jin
Tags: mice, necroptosis, rapamycin, retina, rpe65 protein
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 19. doi:https://doi.org/10.1167/iovs.63.13.19
Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers Open Access
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Bruce A. Berkowitz; Robert H. Podolsky; Karen Lins Childers; Robin Roberts; Ryan Katz; Rida Waseem; Brian M. Robbings; Daniel T. Hass; James B. Hurley; Ian R. Sweet; Cole Goodman; Haohua Qian; Bruno Alvisio; Sam Heaps
Tags: biological markers, mice, mitochondria, rod photoreceptors, transducin
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 22. doi:https://doi.org/10.1167/iovs.63.13.22
Fluorescence Lifetime and Spectral Characteristics of Subretinal Drusenoid Deposits and Their Predictive Value for Progression of Age-Related Macular Degeneration Open Access
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Sebastian Weber; Rowena Simon; Linda-Sophia Schwanengel; Christine A. Curcio; Regine Augsten; Daniel Meller; Martin Hammer
Tags: age-related macular degeneration, digestive tract decontamination, fluorescence, predictive value
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 23. doi:https://doi.org/10.1167/iovs.63.13.23

Retinal Cell Biology

Prolonged Lifetimes of Histologic Autofluorescence in Ectopic Retinal Pigment Epithelium in Age-Related Macular Degeneration Open Access
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Rowena Simon; Marius Jentsch; Parva Karimimousivandi; Dongfeng Cao; Jeffrey D. Messinger; Daniel Meller; Christine A. Curcio; Martin Hammer
Tags: age-related macular degeneration, autofluorescence, retinal pigment epithelium, fluorescence, retinal pigment cell
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 5. doi:https://doi.org/10.1167/iovs.63.13.5
Continuous Hypoxia Reduces Retinal Ganglion Cell Degeneration in a Mouse Model of Mitochondrial Optic Neuropathy Open Access
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Alexander M. Warwick; Howard M. Bomze; Luyu Wang; Mikael Klingeborn; Ying Hao; Sandra S. Stinnett; Sidney M. Gospe, III
Tags: hypoxia, mice, optic nerve disorders, tissue degeneration, mitochondria
Investigative Ophthalmology & Visual Science December 2022, Vol.63, 21. doi:https://doi.org/10.1167/iovs.63.13.21

Erratum

Erratum in: The Effect of Refractive Error on Melanopsin-Driven Pupillary Responses Open Access
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Investigative Ophthalmology & Visual Science December 2022, Vol.63, 11. doi:https://doi.org/10.1167/iovs.63.13.11
Erratum in: AMPK/MFF Activation: Role in Mitochondrial Fission and Mitophagy in Dry Eye Open Access
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Investigative Ophthalmology & Visual Science December 2022, Vol.63, 24. doi:https://doi.org/10.1167/iovs.63.13.24
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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