Volume 64 Issue 2 | IOVS

Biochemistry and Molecular Biology

Calcipotriol Attenuates Form Deprivation Myopia Through a Signaling Pathway Parallel to TGF-β2–Induced Increases in Collagen Expression Open Access

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Shiming Jiao; Peter Sol Reinach; Chengjie Huang; Lan Yu; Huiman Zhuang; Hongli Ran; Fei Zhao; Nethrajeith Srinivasalu; Jia Qu; Xiangtian Zhou

Tags: calcipotriene, cholecalciferol, collagen, myopia, sclera

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 2. doi:https://doi.org/10.1167/iovs.64.2.2

Clinical and Epidemiologic Research

Blink Rate Measured In Situ Decreases While Reading From Printed Text or Digital Devices, Regardless of Task Duration, Difficulty, or Viewing Distance Open Access

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Ngozi Charity Chidi-Egboka; Isabelle Jalbert; Jiaying Chen; Nancy E. Briggs; Blanka Golebiowski

Tags: blinking, cell phones, ocular surfaces, reading (activity), signs and symptoms

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 14. doi:https://doi.org/10.1167/iovs.64.2.14

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Rapid Alternate Flicker Modulates Binocular Interaction in Adults With Abnormal Binocular Vision Open Access

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Yiqiu Lu; Liying Zou; Yiya Chen; Yu Mao; Jinli Zhu; Wenman Lin; Dingqiang Wu; Ruyin Chen; Jia Qu; Jiawei Zhou

Tags: adult, balance, device, equilibrium, eye, imbalance

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 15. doi:https://doi.org/10.1167/iovs.64.2.15

Investigation of Selective Innervation of Extraocular Muscle Compartments Open Access

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Samuel Adade; Vallabh E. Das

Tags: eye, eye movement, motor neurons, muscle of orbit, nerve supply

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 24. doi:https://doi.org/10.1167/iovs.64.2.24

Genetics

De Novo Mutations Contributes Approximately 7% of Pathogenicity in Inherited Eye Diseases Open Access

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Wei Li; Xiang-Dong He; Zheng-Tao Yang; Dong-Ming Han; Yan Sun; Yan-Xian Chen; Xiao-Tong Han; Si-Cheng Guo; Yu-Ting Ma; Xin Jin; Huan-Ming Yang; Ya Gao; Zhuo-Shi Wang; Jian-Kang Li; Wei He

Tags: de novo mutation, epileptiform discharges, eye diseases, genes, improvised explosive devices

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 5. doi:https://doi.org/10.1167/iovs.64.2.5

Genetic Variability of Complement Factor H Has Ethnicity-Specific Associations With Choroidal Thickness Open Access

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Beau J. Fenner; Hengtong Li; Alfred T. L. Gan; Young Seok Song; Yih Chung Tham; Jost B. Jonas; Ya Xing Wang; Ching Yu Cheng; Tien Yin Wong; Kelvin Y. C. Teo; Anna C. S. Tan; Qiao Fan; Chui Ming Gemmy Cheung

Tags: alleles, cohort studies, complement factor h, ethnic group, genetics

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 10. doi:https://doi.org/10.1167/iovs.64.2.10

The Impaired Wound Healing Process Is a Major Factor in Remodeling of the Corneal Epithelium in Adult and Adolescent Patients With Keratoconus Open Access

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Katarzyna Jaskiewicz; Magdalena Maleszka-Kurpiel; Eliza Matuszewska; Michał Kabza; Malgorzata Rydzanicz; Robert Malinowski; Rafal Ploski; Jan Matysiak; Marzena Gajecka

Tags: adolescent, adult, body regions, cornea, impaired wound healing

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 22. doi:https://doi.org/10.1167/iovs.64.2.22

Glaucoma

Asymmetry of Peripapillary Retinal Blood Vessel and Retinal Nerve Fiber Layer Thickness Between Healthy Right and Left Eyes Open Access

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Jack Quach; Glen P. Sharpe; Shaban Demirel; Christopher A. Girkin; Christian Y. Mardin; Alexander F. Scheuerle; Claude F. Burgoyne; Balwantray C. Chauhan; Jayme R. Vianna

Tags: eye, retinal nerve fiber layer, retinal vessels

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 17. doi:https://doi.org/10.1167/iovs.64.2.17

Immunology and Microbiology

The NLRP3 Inflammasome Is Required for Protection Against Pseudomonas Keratitis Open Access

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Abdulraouf Ramadan; Zhiyi Cao; Mihaela Gadjeva; Tanweer S. Zaidi; Vijay A. Rathinam; Noorjahan Panjwani

Tags: inflammasomes, keratitis, nlr family, pyrin domain-containing 3 protein, cornea, pseudomonas

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 11. doi:https://doi.org/10.1167/iovs.64.2.11

Genetic Manipulation of Corynebacterium mastitidis to Better Understand the Ocular Microbiome Open Access

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Yannis Rigas; Benjamin R. Treat; Jackie Shane; Robert M. Q. Shanks; Anthony J. St. Leger

Tags: bacteria, corynebacterium, dna transposons, eye, genes

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 19. doi:https://doi.org/10.1167/iovs.64.2.19

Topical Decorin Reduces Corneal Inflammation and Imparts Neuroprotection in a Mouse Model of Benzalkonium Chloride-induced Corneal Neuropathy Open Access

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Mengliang Wu; Laura E. Downie; Lisa J. Hill; Holly R. Chinnery

Tags: cornea, keratitis, mice, neuropathy, chlorides

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 20. doi:https://doi.org/10.1167/iovs.64.2.20

Lens

Repurposing a Cyclin-Dependent Kinase 1 (CDK1) Mitotic Regulatory Network to Complete Terminal Differentiation in Lens Fiber Cells Open Access

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Allen Taylor; Yumei Gu; Min-Lee Chang; Wenxin Yang; Sarah Francisco; Sheldon Rowan; Eloy Bejarano; Steven Pruitt; Liang Zhu; Grant Weiss; Lisa Brennan; Marc Kantorow; Elizabeth A. Whitcomb

Tags: cdc2 protein kinase, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 6. doi:https://doi.org/10.1167/iovs.64.2.6

Multidisciplinary Ophthalmic Imaging

Variability of Vascular Reactivity in the Retina and Choriocapillaris to Oxygen and Carbon Dioxide Using Optical Coherence Tomography Angiography Open Access

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Bright S. Ashimatey; Xiao Zhou; Zhongdi Chu; Muhammed Alluwimi; Ruikang K. Wang; Amir H. Kashani

Tags: angiogram, carbon dioxide, optical coherence tomography, oxygen, retina

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 9. doi:https://doi.org/10.1167/iovs.64.2.9

Physiology and Pharmacology

Rho Kinase Inhibitor AR-12286 Reverses Steroid-Induced Changes in Intraocular Pressure, Effective Filtration Areas, and Morphology in Mouse Eyes Open Access

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Ruiyi Ren; Anne A. Humphrey; Casey Kopczynski; Haiyan Gong

Tags: eye, filtration, intraocular pressure, kinase inhibitors, mice

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 7. doi:https://doi.org/10.1167/iovs.64.2.7

Retina

Myo/Nog Cells Give Rise to Myofibroblasts During Epiretinal Membrane Formation in a Mouse Model of Proliferative Vitreoretinopathy Open Access

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Mara Crispin; Jacquelyn Gerhart; Alison Heffer; Mark Martin; Fathma Abdalla; Arturo Bravo-Nuevo; Nancy J. Philp; Ajay E. Kuriyan; Mindy George-Weinstein

Tags: antibodies, epiretinal membrane, eye, mice, myofibroblasts

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 1. doi:https://doi.org/10.1167/iovs.64.2.1

Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates Open Access

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Anita Grover; Sethu Sankaranarayanan; Vidhu Mathur; Poojan Suri; Haiyan Qiu; Yaisa Andrews-Zwilling; Kirsten Mease; Lori K. Taylor; Ellen Cahir-McFarland; Sanjay Keswani; Ted Yednock

Tags: body tissue, complement system proteins, eye, immunoglobulin fragments, injections

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 3. doi:https://doi.org/10.1167/iovs.64.2.3

Familial Exudative Vitreoretinopathy and Systemic Abnormalities in Patients With CTNNB1 Mutations Open Access

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Li Huang; Jinglin Lu; You Wang; Limei Sun; Xiaoyan Ding

Tags: beta catenin, familial exudative vitreoretinopathies, mutation

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 18. doi:https://doi.org/10.1167/iovs.64.2.18

Choriocapillaris Flow Signal Impairment in Patients With Pseudoxanthoma Elasticum Open Access

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Anne-Sophie Loewinger; Maximilian Pfau; Philipp Herrmann; Frank G. Holz; Kristina Pfau

Tags: eye, fluid flow, impairment, photoreceptors, pseudoxanthoma elasticum

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 21. doi:https://doi.org/10.1167/iovs.64.2.21

Macular Edema in Central Retinal Vein Occlusion Correlates With Aqueous Fibrinogen Alpha Chain Open Access

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Lasse Jørgensen Cehofski; Kentaro Kojima; Natsuki Kusada; Maja Rasmussen; Danson Vasanthan Muttuvelu; Jakob Grauslund; Henrik Vorum; Bent Honoré

Tags: central retinal vein occlusion, fga gene, macular edema, proteins, proteome

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 23. doi:https://doi.org/10.1167/iovs.64.2.23

Visual Psychophysics and Physiological Optics

Visual Field Abnormalities in Early-Stage Diabetic Retinopathy Assessed by Chromatic Perimetry Open Access

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J. Jason McAnany; Jason C. Park; Jennifer I. Lim

Tags: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, perimetry, visual field defects

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 8. doi:https://doi.org/10.1167/iovs.64.2.8

Lens Thickness Microfluctuations in Young and Prepresbyopic Adults During Steady-State Accommodation Open Access

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Leana Rohman; Marco Ruggeri; Arthur Ho; Jean-Marie Parel; Fabrice Manns

Tags: lens (device), lens, crystalline, steady state, visual accommodation, adult

Investigative Ophthalmology & Visual Science February 2023, Vol.64, 12. doi:https://doi.org/10.1167/iovs.64.2.12

Erratum

Erratum in: Targeting Noncanonical Pyroptosis With a Small Molecular Inhibitor Alleviates Inflammation in the LPS-Induced Keratitis Mouse Model Open Access

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Investigative Ophthalmology & Visual Science February 2023, Vol.64, 4. doi:https://doi.org/10.1167/iovs.64.2.4

Erratum in: Investigation of the Protective Effect of Extracellular Vesicle miR-124 on Retinal Ganglion Cells Using a Photolabile Paper-Based Chip Open Access

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Investigative Ophthalmology & Visual Science February 2023, Vol.64, 13. doi:https://doi.org/10.1167/iovs.64.2.13

Erratum in: Novel Discoveries of the Relationship Between the Vitreous Zonule and the Anterior Segment Characteristics in Eyes With Primary Angle-Closure Disease Open Access

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Investigative Ophthalmology & Visual Science February 2023, Vol.64, 16. doi:https://doi.org/10.1167/iovs.64.2.16

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