Volume 64 Issue 3 | IOVS

Editorial

Reviewers Open Access

PDF

Tags: acetylcholine, achondroplasia, arthritis, juvenile rheumatoid, burns, calculi

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 25. doi:https://doi.org/10.1167/iovs.64.3.25

Biochemistry and Molecular Biology

The RNA m⁵C Methylase NSUN2 Modulates Corneal Epithelial Wound Healing Open Access

PDF

Guangying Luo; Weiwei Xu; Xiaoyan Chen; Wenji Xu; Shuai Yang; Jiao Wang; Yong Lin; Peter S. Reinach; Dongsheng Yan

Tags: rna, methyltransferase, cornea, wound healing, epithelium

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 5. doi:https://doi.org/10.1167/iovs.64.3.5

Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV) Open Access

PDF

Yuanyuan Chen; Cheng Wu; Shanzhen Peng; Dianlei Guo; Hong Ouyang; Yanhong Wei; Rong Ju; Xiaoyan Ding; Zhi Xie; Chunqiao Liu

Tags: mice, persistent hyperplastic primary vitreous, vitreous body, melanocytes

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 8. doi:https://doi.org/10.1167/iovs.64.3.8

Tissue-Specific Sex Difference in Mouse Eye and Brain Metabolome Under Fed and Fasted States Open Access

PDF

Meghashri Saravanan; Rong Xu; Olivia Roby; Yekai Wang; Siyan Zhu; Amy Lu; Jianhai Du

Tags: body tissue, brain, eye, metabolism, metabolites

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 18. doi:https://doi.org/10.1167/iovs.64.3.18

Missense Mutations in MAB21L1: Causation of Novel Autosomal Dominant Ocular BAMD Syndrome Open Access

PDF

Panfeng Wang; Pengsen Wu; Junwen Wang; Yiyan Zeng; Yi Jiang; Yingwei Wang; Shiqiang Li; Xueshan Xiao; Qingjiong Zhang

Tags: missense mutation, phenotype, syndrome, family

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 19. doi:https://doi.org/10.1167/iovs.64.3.19

Clinical and Epidemiologic Research

Physical Activity Is Associated With Macular Thickness: A Multi-Cohort Observational Study Open Access

PDF

Ella C. Berry; Henry N. Marshall; Sean Mullany; Santiago Diaz Torres; Joshua Schmidt; Daniel Thomson; Lachlan S. W. Knight; Georgina L. Hollitt; Ayub Qassim; Bronwyn Ridge; Angela Schulz; Mark M. Hassall; Thi Thi Nguyen; Stewart Lake; Richard A. Mills; Ashish Agar; Anna Galanopoulos; John Landers; Paul R. Healey; Stuart L. Graham; Alex W. Hewitt; Stuart MacGregor; Robert J. Casson; Owen M. Siggs; Jamie E. Craig

Tags: cohort studies, physical activity, biobanks

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 11. doi:https://doi.org/10.1167/iovs.64.3.11

Cornea

Celastrol Alleviates Corneal Stromal Fibrosis by Inhibiting TGF-β1/Smad2/3-YAP/TAZ Signaling After Descemet Stripping Endothelial Keratoplasty Open Access

PDF

Ruixing Liu; Jingguo Li; Zhihua Guo; Dandan Chu; Chengcheng Li; Liuqi Shi; Junjie Zhang; Lei Zhu; Zhanrong Li

Tags: cornea, descemet stripping endothelial keratoplasty, fibrosis, signal transduction, proteins

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 9. doi:https://doi.org/10.1167/iovs.64.3.9

Overactivation of Norepinephrine–β2-Adrenergic Receptor Axis Promotes Corneal Neovascularization Open Access

PDF

Qiaoqiao Dong; Benxiang Qi; Bin Zhang; Xiaoyun Zhuang; Shijiu Chen; Qingjun Zhou; Bi Ning Zhang; Suxia Li

Tags: choroidal neovascularization, cornea, corneal neovascularization, mice, norepinephrine

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 20. doi:https://doi.org/10.1167/iovs.64.3.20

Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model Open Access

PDF

Yu Chen; Jiheng Pu; Xinda Li; Lili Lian; Chaoxiang Ge; Zuimeng Liu; Weizhuo Wang; Ling Hou; Wei Chen; Jinyang Li

Tags: corneal epithelium, dry eye syndromes, lacrimal gland, mice, dna

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 26. doi:https://doi.org/10.1167/iovs.64.3.26

Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Mouse Corneal Epithelial Cells Open Access

PDF

Zhao-Jing Lu; Jin-Guo Ye; Dong-Liang Wang; Meng-Ke Li; Qi-Kai Zhang; Zhong Liu; Yan-Jing Huang; Cai-Neng Pan; Yu-Heng Lin; Zhuo-Xing Shi; Ying-Feng Zheng

Tags: corneal epithelial cells, corneal epithelium, genes, mice, rna, small cytoplasmic

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 30. doi:https://doi.org/10.1167/iovs.64.3.30

IFN-γ Facilitates Corneal Epithelial Cell Pyroptosis Through the JAK2/STAT1 Pathway in Dry Eye Open Access

PDF

Xue Yang; Xin Zuo; Hao Zeng; Kai Liao; Dalian He; Bowen Wang; Jin Yuan

Tags: cornea, corneal epithelial cells, dry eye syndromes, pyroptosis, stat1 gene

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 34. doi:https://doi.org/10.1167/iovs.64.3.34

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

The Saccade Main Sequence in Patients With Retinitis Pigmentosa and Advanced Age-Related Macular Degeneration Open Access

PDF

Leslie Guadron; Samuel A. Titchener; Carla J. Abbott; Lauren N. Ayton; John van Opstal; Matthew A. Petoe; Jeroen Goossens

Tags: saccades, kinematics, visual fields, retinitis pigmentosa, eye

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 1. doi:https://doi.org/10.1167/iovs.64.3.1

Ocular Deformations in Spaceflight-Associated Neuro-Ocular Syndrome and Idiopathic Intracranial Hypertension Open Access

PDF

Patrick A. Sibony; Steven S. Laurie; Connor R. Ferguson; Laura P. Pardon; Millennia Young; F. James Rohlf; Brandon R. Macias

Tags: displacements, edema, eye, papilledema, pseudotumor cerebri

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 32. doi:https://doi.org/10.1167/iovs.64.3.32

Genetics

Causal Relationships Between Glycemic Traits and Myopia Open Access

PDF

Fen-Fen Li; Meng-Chao Zhu; Yi-Lei Shao; Fan Lu; Quan-Yong Yi; Xiu-Feng Huang

Tags: myopia, adiponectin, hemoglobin a, glycosylated

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 7. doi:https://doi.org/10.1167/iovs.64.3.7

The Genetic Confirmation and Clinical Characterization of LOXL3-Associated MYP28: A Common Type of Recessive Extreme High Myopia Open Access

PDF

Yi Jiang; Lin Zhou; Yingwei Wang; Jiamin Ouyang; Shiqiang Li; Xueshan Xiao; Xiaoyun Jia; Junwen Wang; Zhen Yi; Wenmin Sun; Xiaodong Jiao; Panfeng Wang; J. Fielding Hejtmancik; Qingjiong Zhang

Tags: genetics, myopia

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 24. doi:https://doi.org/10.1167/iovs.64.3.24

Glaucoma

24-Hour Monitoring of Intraocular Pressure Fluctuations Using a Contact Lens Sensor: Diagnostic Performance for Glaucoma Progression Open Access

PDF

Thibaut Gaboriau; Remi Dubois; Boris Foucque; Florence Malet; Cedric Schweitzer

Tags: contact lenses, glaucoma, intraocular pressure, sensor, visual fields

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 3. doi:https://doi.org/10.1167/iovs.64.3.3

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant Open Access

PDF

W. Daniel Stamer; Kristin M. Perkumas; Min H. Kang; Mohammed Dibas; Michael R. Robinson; Douglas J. Rhee

Tags: bimatoprost, implants, intraocular pressure, gene expression, interstitial collagenase

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 15. doi:https://doi.org/10.1167/iovs.64.3.15

Choroidal Microvasculature Dropout in the Absence of Parapapillary Atrophy in POAG Open Access

PDF

Eun Ji Lee; Ji Eun Song; Hye Seong Hwang; Jeong-Ah Kim; Seung Hyen Lee; Tae-Woo Kim

Tags: atrophy, eye, glaucoma, microvascular network, open-angle glaucoma

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 21. doi:https://doi.org/10.1167/iovs.64.3.21

Immunology and Microbiology

Time-Course Transcriptomic Analysis Reveals the Crucial Roles of PANoptosis in Fungal Keratitis Open Access

PDF

Xizhan Xu; Yuan Wei; Jinding Pang; Zhenyu Wei; Leying Wang; Qiankun Chen; Zhiqun Wang; Yang Zhang; Kexin Chen; Yan Peng; Zijun Zhang; Jiamin Liu; Yuheng Zhang; Zi-Bing Jin; Qingfeng Liang

Tags: cornea, fungal keratitis, immune response, mice, mycoses

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 6. doi:https://doi.org/10.1167/iovs.64.3.6

The Role of C-X-C Chemokines in Staphylococcus aureus Endophthalmitis Open Access

PDF

Phillip S. Coburn; Aaron C. Parrott; Frederick C. Miller; Austin L. LaGrow; Md Huzzatul Mursalin; Michelle C. Callegan

Tags: chemokine (c-x-c motif) ligand 1, cxc chemokines, endophthalmitis, eye, eye infections

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 10. doi:https://doi.org/10.1167/iovs.64.3.10

T-Cell Repertoire Analysis in the Conjunctiva of Murine Dry Eye Model Open Access

PDF

Xiaorui Bao; Yanlin Zhong; Chunyan Yang; Yujie Chen; Yi Han; Xiang Lin; Caihong Huang; Kejia Wang; Zuguo Liu; Cheng Li

Tags: conjunctiva, dry eye syndromes, mice, t-lymphocytes

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 14. doi:https://doi.org/10.1167/iovs.64.3.14

Scleral Proteome in Noninfectious Scleritis Unravels Upregulation of Filaggrin-2 and Signs of Neovascularization Open Access

PDF

Daphne P. C. Vergouwen; Josianne C. Ten Berge; Coskun Guzel; Thierry P. P. van den Bosch; Robert M. Verdijk; Aniki Rothova; Theo M. Luider; Marco W. J. Schreurs

Tags: filaggrin proteins, flg gene, neovascularization, pathologic, proteins, proteome

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 27. doi:https://doi.org/10.1167/iovs.64.3.27

Lens

SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation Open Access

PDF

Lili Lian; Zhenmin Le; Zhenzhen Wang; Ying-ao Chen; Xiaodong Jiao; Hang Qi; J. Fielding Hejtmancik; Xiaoyin Ma; Qinxiang Zheng; Yueping Ren

Tags: cataract, glucose, inflammasomes, nlr family, pyrin domain-containing 3 protein

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 16. doi:https://doi.org/10.1167/iovs.64.3.16

Multidisciplinary Ophthalmic Imaging

Correlation Between Retinal Vessel Diameters and Uveitis Activity Open Access

PDF

Federico Zicarelli; Aniruddha Agarwal; Chiara Rizzi; Marta Oldani; Giovanni Staurenghi; Alessandro Invernizzi

Tags: retinal vessels, uveitis, eye, inflammation

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 13. doi:https://doi.org/10.1167/iovs.64.3.13

Physiology and Pharmacology

Differences in Outflow Facility Between Angiographically Identified High- Versus Low-Flow Regions of the Conventional Outflow Pathways in Porcine Eyes Open Access

PDF

Clemens A. Strohmaier; Fiona S. McDonnell; Xiaowei Zhang; Daniel Wanderer; W. Daniel Stamer; Robert N. Weinreb; Alex S. Huang

Tags: eye, fluid flow, suidae, perfusion

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 29. doi:https://doi.org/10.1167/iovs.64.3.29

Retina

Multiple Bioenergy-Linked OCT Biomarkers Suggest Greater-Than-Normal Rod Mitochondria Activity Early in Experimental Alzheimer's Disease Open Access

PDF

Bruce A. Berkowitz; Robert H. Podolsky; Karen L. Childers; Robin Roberts; Rida Waseem

Tags: alzheimer's disease, biological markers, embryonic lethal mutation, mice, mitochondria

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 12. doi:https://doi.org/10.1167/iovs.64.3.12

Ferritin But Not Iron Increases in Retina Upon Systemic Iron Overload in Diabetic and Iron-Dextran Injected Mice Open Access

PDF

Aina Bonet; Judit Pampalona; Eduard Jose-Cunilleras; Víctor Nacher; Jesús Ruberte

Tags: diabetes mellitus, ferritin, iron, iron overload, mice

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 22. doi:https://doi.org/10.1167/iovs.64.3.22

Phenotypic Variability of Retinal Disease Among a Cohort of Patients With Variants in the CLN Genes Open Access

PDF

Masha Kolesnikova; Jose Ronaldo Lima de Carvalho, Jr.; Jin Kyun Oh; Megan Soucy; Aykut Demirkol; Angela H. Kim; Stephen H. Tsang; Mark P. Breazzano

Tags: cohort studies, diagnostic imaging, electrophysiology, genes, genotype

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 23. doi:https://doi.org/10.1167/iovs.64.3.23

Vitreous Fatty Amides and Acyl Carnitines Are Altered in Intermediate Age-Related Macular Degeneration Open Access

PDF

Chang-Ki Yoon; Ye An Kim; Un Chul Park; Seung-hyun Kwon; Young Lee; Hyun Ju Yoo; Je Hyun Seo; Hyeong Gon Yu

Tags: age-related macular degeneration, amides, metabolites, metabolome, vitreous body

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 28. doi:https://doi.org/10.1167/iovs.64.3.28

Retinal Cell Biology

Clinicopathologic Findings in Three Siblings With Geographic Atrophy Open Access

PDF

Malia M. Edwards; D. Scott McLeod; Mengxi Shen; Rhonda Grebe; Janet S. Sunness; Imran A. Bhutto; Erin McDonnell; Alexandra M. Pado; Giovanni Gregori; Philip J. Rosenfeld; Gerard A. Lutty

Tags: atrophy, drusen, eye, retina, relationship - sibling

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 2. doi:https://doi.org/10.1167/iovs.64.3.2

Kif5a Regulates Mitochondrial Transport in Developing Retinal Ganglion Cells In Vitro Open Access

PDF

Satoshi Yokota; Sahil H. Shah; Emma Lee Huie; Runxia Rain Wen; Ziming Luo; Jeffrey L. Goldberg

Tags: axonal transport, biological transport, mitochondria, mitochondrial transport, retinal ganglion cells

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 4. doi:https://doi.org/10.1167/iovs.64.3.4

Lithium Chloride Exerts Anti-Inflammatory and Neuroprotective Effects by Inhibiting Microglial Activation in LPS-Induced Retinal Injury Open Access

PDF

Nandan Wu; Qian Luo; Yuke Huang; Linxi Wan; Xiangtao Hou; Zihua Jiang; Yan Li; Jin Qiu; Pei Chen; Keming Yu; Jing Zhuang; Ying Yang

Tags: anti-inflammatory agents, lithium chloride, mice, microglia, neuroinflammatory diseases

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 35. doi:https://doi.org/10.1167/iovs.64.3.35

Visual Neuroscience

Spatial Resolution Evaluation Based on Experienced Visual Categories With Sweep Evoked Periodic EEG Activity Open Access

PDF

Coralie Hemptinne; Nathan Hupin; Aliette Lochy; Demet Yüksel; Bruno Rossion

Tags: electroencephalography, face, word recognition, individuation

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 17. doi:https://doi.org/10.1167/iovs.64.3.17

A Duration-Dependent Interaction Between High-Intensity Light and Unrestricted Vision in the Drive for Myopia Control Open Access

PDF

Sayantan Biswas; Arumugam R. Muralidharan; Bjorn Kaijun Betzler; Joanna Marie Fianza Busoy; Veluchamy A. Barathi; Royston K. Y. Tan; Wan Yu Shermaine Low; Dan Milea; Biten K. Kathrani; Noel A. Brennan; Raymond P. Najjar

Tags: myopia, refraction, vision, eye

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 31. doi:https://doi.org/10.1167/iovs.64.3.31

Erratum

Erratum in: Genetic Variability of Complement Factor H Has Ethnicity-Specific Associations With Choroidal Thickness Open Access

PDF

Investigative Ophthalmology & Visual Science March 2023, Vol.64, 33. doi:https://doi.org/10.1167/iovs.64.3.33

This feature is available to authenticated users only.

To View More...

You must be signed into an individual account to use this feature.