Volume 64 Issue 4 | IOVS

Biochemistry and Molecular Biology

Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis Open Access

PDF

Jiayu Bao; Peng Zhang; Binge Wu; Jingyi Wang; Siyuan Li; Ao Li; Ying Jie

Tags: allergic conjunctivitis, immunoglobulin e, inflammation, mice, proteins

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 5. doi:https://doi.org/10.1167/iovs.64.4.5

AURKB Enhances Chromosomal Remodeling of Telomeric Genes and Accelerates Tumorigenesis of Uveal Melanoma Open Access

PDF

Huixue Wang; Hui Pan; Xiaolin Huang

Tags: chromosomes, genes, tumorigenesis, uveal melanoma, histone h3

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 23. doi:https://doi.org/10.1167/iovs.64.4.23

Clinical and Epidemiologic Research

Prevalence and Characteristics of Peripapillary Gamma Zone in Children With Different Refractive Status: The Hong Kong Children Eye Study Open Access

PDF

Xiu Juan Zhang; Duncan Ka Shun Chau; Yu Meng Wang; Cynthia Sze Hang Cheung; Hei-Nga Chan; Jian Shi; Ka Ming Nip; Shumin Tang; Ryan C. F. Chan; Alistair Lau; Sit Hui Kei; Ka Wai Kam; Alvin L. Young; Li Jia Chen; Clement C. Tham; Kyoko Ohno-Matsui; Chi Pui Pang; Jason C. Yam

Tags: child, eye, hong kong, prevalence

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 4. doi:https://doi.org/10.1167/iovs.64.4.4

Potential Choroidal Mechanisms Underlying Atropine's Antimyopic and Rebound Effects: A Mediation Analysis in a Randomized Clinical Trial Open Access

PDF

Hannan Xu; Luyao Ye; Yajun Peng; Tao Yu; Shanshan Li; Shijun Weng; Yelin Huang; Yuzhong Chen; Ying Fan; Haidong Zou; Jiangnan He; Jianfeng Zhu; Xun Xu

Tags: atropine, mediation analysis, myopia, clinical trials, cortical blindness

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 13. doi:https://doi.org/10.1167/iovs.64.4.13

The Causal Effect of Education on Myopia: Evidence That More Exposure to Schooling, Rather Than Increased Age, Causes the Onset of Myopia Open Access

PDF

Xiaohu Ding; Ian G. Morgan; Yin Hu; Xianghua Tang; Jiayu Zhang; Lan Guo; Yangfeng Guo; Nali Deng; Xueying Du; Yingfeng Zheng; Mingguang He; Ciyong Lu; Xiao Yang; Yizhi Liu

Tags: educational status, knowledge acquisition, myopia, school (environment)

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 25. doi:https://doi.org/10.1167/iovs.64.4.25

Contrast Increment and Decrement Processing in Individuals With and Without Diabetes Open Access

PDF

Vanessa Thien Sze Tang; Robert Charles Andrew Symons; Spiros Fourlanos; Daryl Guest; Allison Maree McKendrick

Tags: contrast sensitivity, diabetes mellitus, diabetes mellitus, type 2, reaction time, judgment

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 26. doi:https://doi.org/10.1167/iovs.64.4.26

Cornea

On the Mechanical Roles of Glycosaminoglycans in the Tensile Properties of Porcine Corneal Stroma Open Access

PDF

Hamed Hatami-Marbini

Tags: cornea, corneal stroma, glycosaminoglycans, suidae, enzymes

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 3. doi:https://doi.org/10.1167/iovs.64.4.3

Schwann Cells Are Key Regulators of Corneal Epithelial Renewal Open Access

PDF

Kaveh Mirmoeini; Kiana Tajdaran; Jennifer Zhang; Tessa Gordon; Asim Ali; David R. Kaplan; Konstantin Feinberg; Gregory H. Borschel

Tags: cornea, epithelium, spinal cord stimulation, wound healing, schwann cells

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 7. doi:https://doi.org/10.1167/iovs.64.4.7

The CXCR4/miR-1910-5p/MMRN2 Axis Is Involved in Corneal Neovascularization by Affecting Vascular Permeability Open Access

PDF

Xiao Wang; Zedu Cui; Xi Chen; Qian Luo; Zihua Jiang; Xuan Liu; Yuke Huang; Jingyi Jiang; Shuilian Chen; Jin Qiu; Yan Li; Keming Yu; Jing Zhuang

Tags: choroidal neovascularization, cxcr4 receptors, corneal neovascularization, hypoxia, cornea

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 10. doi:https://doi.org/10.1167/iovs.64.4.10

Mice Deficient in TAZ (Wwtr1) Demonstrate Clinical Features of Late-Onset Fuchs’ Endothelial Corneal Dystrophy Open Access

PDF

Brian C. Leonard; Sangwan Park; Soohyun Kim; Laura J. Young; Iman Jalilian; Krista Cosert; Xunzhi Zhang; Jessica M. Skeie; Hanna Shevalye; Nayeli Echeverria; Vanessa Rozo; Xin Gong; Chao Xing; Christopher J. Murphy; Mark A. Greiner; V. Vinod Mootha; Vijay Krishna Raghunathan; Sara M. Thomasy

Tags: cornea, endothelium, hereditary corneal dystrophy, mice, signs and symptoms

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 22. doi:https://doi.org/10.1167/iovs.64.4.22

Genetics

Multi-Polymorphism Analysis Reveals Joint Effects in Males With Chronic Central Serous Chorioretinopathy Open Access

PDF

Zhen Ji Chen; Danny S. C. Ng; Ling-Ping Cen; Tsz Kin Ng; Mary Ho; Marten E. Brelen; Tai-Ping Li; Shi Yao Lu; Pancy O. S. Tam; Alvin L. Young; Weiqi Chen; Jason C. Yam; Haoyu Chen; Clement C. Tham; Chi Pui Pang; Li Jia Chen

Tags: central serous chorioretinopathy, chinese (other dialects), chinese people, cohort studies, genetics

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 19. doi:https://doi.org/10.1167/iovs.64.4.19

Unique Haplotypes in OPN1LW as a Common Cause of High Myopia With or Without Protanopia: A Potential Window Into Myopic Mechanism Open Access

PDF

Yingwei Wang; Wenmin Sun; Xueshan Xiao; Yi Jiang; Jiamin Ouyang; Junwen Wang; Zhen Yi; Shiqiang Li; Xiaoyun Jia; Panfeng Wang; J. Fielding Hejtmancik; Qingjiong Zhang

Tags: haplotypes, myopia, retinal cone, genes, mosaicism

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 29. doi:https://doi.org/10.1167/iovs.64.4.29

Retinal Aging Transcriptome and Cellular Landscape in Association With the Progression of Age-Related Macular Degeneration Open Access

PDF

Jiang-Hui Wang; Raymond C. B. Wong; Guei-Sheung Liu

Tags: age-related macular degeneration, aging, genes, retina, neural retina

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 32. doi:https://doi.org/10.1167/iovs.64.4.32

Glaucoma

Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia Open Access

PDF

Mahmoud T. KhalafAllah; Preston A. Fuchs; Fred Nugen; Mustapha El Hamdaoui; Alexander Levy; David T. Redden; Brian C. Samuels; Rafael Grytz

Tags: american society of clinical oncology, body tissue, bruch's basal membrane, child, eye

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 2. doi:https://doi.org/10.1167/iovs.64.4.2

Structure Function Relationships of Vessel Density and Retinal Nerve Fiber Layer Thickness in Early Glaucomatous Eyes With High Myopia Open Access

PDF

Kaho Akiyama; Hitomi Saito; Shiroaki Shirato; Aiko Iwase; Shuichiro Aoki; Koichiro Sugimoto; Takashi Fujishiro; Hiroshi Murata; Rei Sakata; Megumi Honjo; Makoto Aihara

Tags: eye, glaucoma, myopia, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 14. doi:https://doi.org/10.1167/iovs.64.4.14

Neuroprotection of SRT2104 in Murine Ischemia/Reperfusion Injury Through the Enhancement of Sirt1-Mediated Deacetylation Open Access

PDF

Xue Bai; Dan Ye; Yuxun Shi; Matthew Fan; Peng Lu; Yanlin Feng; Chenyang Hu; Jing Liao; Kaixuan Cui; Xiaoyu Tang; Peiqi Wu; Fan Xu; Yue Xu; Jingjing Huang

Tags: mice, retina, wounds and injuries, neuroprotection, reperfusion injury

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 31. doi:https://doi.org/10.1167/iovs.64.4.31

Immunology and Microbiology

The miRNA Landscape of Lacrimal Glands in a Murine Model of Autoimmune Dacryoadenitis Open Access

PDF

Shruti Singh Kakan; Xiaoyang Li; Maria C. Edman; Curtis T. Okamoto; Brooke E. Hjelm; Sarah F. Hamm-Alvarez

Tags: dacryoadenitis, mice, micrornas, autoimmunity, sjogren's syndrome

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 1. doi:https://doi.org/10.1167/iovs.64.4.1

Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model Open Access

PDF

Zhiyuan Yu; Ghasem Yazdanpanah; Jehan Alam; Cintia S. de Paiva; Stephen Pflugfelder

Tags: corneal epithelium, dry eye syndromes, nf-kappa b, stress, nlr family, pyrin domain-containing 3 protein

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 8. doi:https://doi.org/10.1167/iovs.64.4.8

Effects of Plasma-Derived Exosomal miRNA-19b-3p on Treg/T Helper 17 Cell Imbalance in Behçet's Uveitis Open Access

PDF

Qingyan Jiang; Qingfeng Wang; Shiyao Tan; Jinyu Cai; Xingsheng Ye; Guannan Su; Peizeng Yang

Tags: behcet syndrome, exosomes, imbalance, micrornas, plasma

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 28. doi:https://doi.org/10.1167/iovs.64.4.28

Lens

BMP-4 and BMP-7 Inhibit EMT in a Model of Anterior Subcapsular Cataract in Part by Regulating the Notch Signaling Pathway Open Access

PDF

Fanying Jiang; Yingyan Qin; Yuanfan Yang; Zhen Li; Baoyue Cui; Rong Ju; Mingxing Wu

Tags: ambulatory surgery center, epithelial to mesenchymal transition, notch signaling pathway, subcapsular cataract, wounds and injuries

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 12. doi:https://doi.org/10.1167/iovs.64.4.12

Nonmuscle Myosin IIA Regulates the Precise Alignment of Hexagonal Eye Lens Epithelial Cells During Fiber Cell Formation and Differentiation Open Access

PDF

Sadia T. Islam; Catherine Cheng; Justin Parreno; Velia M. Fowler

Tags: lens (device), lens, crystalline, epithelial cells, mice, myosins

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 20. doi:https://doi.org/10.1167/iovs.64.4.20

Age-Dependent Changes in the Water Content and Optical Power of the In Vivo Mouse Lens Revealed by Multi-Parametric MRI and Optical Modeling Open Access

PDF

Xingzheng Pan; Eric R. Muir; Caterina Sellitto; Kehao Wang; Catherine Cheng; Barbara Pierscionek; Paul J. Donaldson; Thomas W. White

Tags: lens (device), lens, crystalline, mice, optics, water

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 24. doi:https://doi.org/10.1167/iovs.64.4.24

Endoplasmic Reticulum Stress and the Lysosomal Pathway Play Crucial Roles in the Progression of βB2-Crystallin Mutation-Induced Congenital Cataracts in Mice Open Access

PDF

Wei Xiao; Weimin Yang; Xinyu Zhang; Xiaoqian Deng; Xiaoyun Chen

Tags: congenital cataract, crystallins, lens (device), lens, crystalline, mice

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 34. doi:https://doi.org/10.1167/iovs.64.4.34

Retina

The Relationship Between Retinal and Choroidal Thickness and Adiponectin Concentrations in Patients With Type 2 Diabetes Mellitus Open Access

PDF

Hyun Seung Yang; Young Je Choi; Hee Yong Han; Hak Su Kim; So Hyun Park; Jeongmin Kim; Sangkyung Choi

Tags: adiponectin, diabetes mellitus, type 2, hypertension, vascular endothelial growth factor a, cytokine

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 6. doi:https://doi.org/10.1167/iovs.64.4.6

Prenatal Carotenoid Supplementation With Lutein or Zeaxanthin Ameliorates Oxygen-Induced Retinopathy (OIR) in Bco2^−/− Macular Pigment Mice Open Access

PDF

Ranganathan Arunkumar; Binxing Li; Emmanuel K. Addo; Mary Elizabeth Hartnett; Paul S. Bernstein

Tags: carotenoids, lutein, macular pigment, mice, oxygen

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 9. doi:https://doi.org/10.1167/iovs.64.4.9

Intravitreal Short-Hairpin RNA Attenuated Adeno-Associated Virus–Induced Knockdown of Amphiregulin and Axial Elongation in Experimental Myopia Open Access

PDF

Li Dong; Rui-Heng Zhang; Hao-Tian Wu; He-Yan Li; Wen-Da Zhou; Xu-Han Shi; Chu-Yao Yu; Yi-Tong Li; Yi-Fan Li; Jost B. Jonas; Wen-Bin Wei

Tags: adeno-associated virus, amphiregulin, attenuation, myopia, retinal pigment cell

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 11. doi:https://doi.org/10.1167/iovs.64.4.11

Decreased Macular Choriocapillaris Perfusion in Eyes With Macular Reticular Pseudodrusen Imaged With Swept-Source OCT Angiography Open Access

PDF

Jianqing Li; Ziyu Liu; Jie Lu; Mengxi Shen; Yuxuan Cheng; Nadia Siddiqui; Hao Zhou; Qinqin Zhang; Jeremy Liu; Gissel Herrera; Farhan E. Hiya; Giovanni Gregori; Ruikang K. Wang; Philip J. Rosenfeld

Tags: angiogram, eye, perfusion, reticular pseudodrusen, drusen

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 15. doi:https://doi.org/10.1167/iovs.64.4.15

Longitudinal Observation of Retinal Response to Optic Nerve Transection in Rats Using Visible Light Optical Coherence Tomography Open Access

PDF

Shaohua Pi; Bingjie Wang; Min Gao; William Cepurna; Diana C. Lozano; John C. Morrison; Yali Jia

Tags: eye, nerve fibers, optic nerve, optical coherence tomography, oxygen saturation measurement

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 17. doi:https://doi.org/10.1167/iovs.64.4.17

Rod and Cone Dark Adaptation in Congenital Aniridia and Its Association With Retinal Structure Open Access

PDF

Hilde R. Pedersen; Stuart J. Gilson; Erlend C. S. Landsend; Øygunn A. Utheim; Tor P. Utheim; Rigmor C. Baraas

Tags: aniridia, dark adaptation, retina, retinal cone, rod photoreceptors

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 18. doi:https://doi.org/10.1167/iovs.64.4.18

Capturing the Transition From Intermediate to Neovascular AMD: Longitudinal Inner Retinal Thinning and Factors Associated With Neuronal Loss Open Access

PDF

Enrico Borrelli; Costanza Barresi; Giorgio Lari; Alessandro Berni; Marco Battista; Michele Reibaldi; Maria Lucia Cascavilla; Francesco Bandello

Tags: anti-vascular endothelial growth factor therapy, exudative age-related macular degeneration, eye, follow-up visit, macular neovascularization

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 21. doi:https://doi.org/10.1167/iovs.64.4.21

Insights Into PROM1-Macular Disease Using Multimodal Imaging Open Access

PDF

Maarjaliis Paavo; Winston Lee; Rait Parmann; Jose Ronaldo Lima de Carvalho, Jr.; Jana Zernant; Stephen H. Tsang; Rando Allikmets; Janet R. Sparrow

Tags: eye, multimodal imaging, retinal imaging, spectral domain-optical coherence tomography, macula lutea

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 27. doi:https://doi.org/10.1167/iovs.64.4.27

Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration Open Access

PDF

Dawiyat Massoudi; Seán Gorman; Yien-Ming Kuo; Takao Iwawaki; Scott A. Oakes; Feroz R. Papa; Douglas B. Gould

Tags: aging, mice, photoreceptors, retina, retinal degeneration

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 30. doi:https://doi.org/10.1167/iovs.64.4.30

Blockade of Annexin A2 Prevents Early Microvasculopathy in Murine Models of Diabetic Retinopathy Open Access

PDF

Valentina Dallacasagrande; Wei Liu; Dena Almeida; Min Luo; Katherine A. Hajjar

Tags: annexin a2, diabetes mellitus, mice, diabetic retinopathy, retina

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 33. doi:https://doi.org/10.1167/iovs.64.4.33

Visual Neuroscience

Modifications in Macular Perfusion and Neuronal Loss After Acute Traumatic Brain Injury Open Access

PDF

Jenny L. Hepschke; Elinor Laws; Noor H. Bin Saliman; Stefana Juncu; Ella Courtie; Antonio Belli; Richard J. Blanch

Tags: perfusion, traumatic brain injuries

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 35. doi:https://doi.org/10.1167/iovs.64.4.35

Visual Psychophysics and Physiological Optics

Relative Myopic Defocus in the Superior Retina as an Indicator of Myopia Development in Children Open Access

PDF

Zhenghua Lin; Xiaoyun Xi; Longbo Wen; Zhiwei Luo; Pablo Artal; Zhikuan Yang; Weizhong Lan

Tags: myopia, retina

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 16. doi:https://doi.org/10.1167/iovs.64.4.16

Erratum

Erratum in: Ocular Deformations in Spaceflight-Associated Neuro-Ocular Syndrome and Idiopathic Intracranial Hypertension Open Access

PDF

Investigative Ophthalmology & Visual Science April 2023, Vol.64, 36. doi:https://doi.org/10.1167/iovs.64.4.36

This feature is available to authenticated users only.

To View More...

You must be signed into an individual account to use this feature.