Volume 64 Issue 5 | IOVS

Müller's Muscle as a Sensory Proprioceptive Organ: Histological and Histochemical Analysis Open Access

Daphna Landau-Prat; Chen Mayer; Nir Gomel; Mattan Arazi; Ofira Zloto; Amir Dori; Guy J. Ben Simon

Tags: methylene blue, muscle, eyelid, axon, myelin sheath

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 18. doi:https://doi.org/10.1167/iovs.64.5.18

Exogenous All-Trans Retinoic Acid Induces Myopia and Alters Scleral Biomechanics in Mice Open Access

Dillon M. Brown; Jianshi Yu; Praveen Kumar; Quinn M. Paulus; Michael A. Kowalski; Jay M. Patel; Maureen A. Kane; C. Ross Ethier; Machelle T. Pardue

Tags: mice, myopia, sclera, tretinoin, biomechanics

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 22. doi:https://doi.org/10.1167/iovs.64.5.22

Cornea

The Presence of Guttae in Fuchs Endothelial Corneal Dystrophy Explants Correlates With Cellular Markers of Disease Progression Open Access

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Sébastien Méthot; Stéphanie Proulx; Isabelle Brunette; Patrick J. Rochette

Tags: disease progression, endothelium, hereditary corneal dystrophy, mitochondria, chronic exertional compartment syndrome

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 13. doi:https://doi.org/10.1167/iovs.64.5.13

The TCF4 Trinucleotide Repeat Expansion of Fuchs’ Endothelial Corneal Dystrophy: Implications for the Anterior Segment of the Eye Open Access

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Jiaxin Hu; Xin Gong; Samantha T. Johnson; David R. Corey; V. Vinod Mootha

Tags: body tissue, cornea, corneal endothelium, corneal stroma, endothelium

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 16. doi:https://doi.org/10.1167/iovs.64.5.16

Norepinephrine as the Intrinsic Contributor to Contact Lens–Induced Pseudomonas aeruginosa Keratitis Open Access

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Bi Ning Zhang; Benxiang Qi; Wai Kit Chu; Fangying Song; Suxia Li; Qiaoqiao Dong; Zheng Shao; Bin Zhang; Xianli Du; Xiubin Ma; Vishal Jhanji; Qingjun Zhou

Tags: adrb2 gene, beta-2 adrenergic receptors, contact lenses, cornea, infections

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 26. doi:https://doi.org/10.1167/iovs.64.5.26

Effects of Mirogabalin on Hyperalgesia and Chronic Ocular Pain in Tear-Deficient Dry-Eye Rats Open Access

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Kasumi Kikuchi; Yoshiaki Tagawa; Miyuki Murata; Susumu Ishida

Tags: cornea, dry eye syndromes, hyperalgesia, ocular pain, rats

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 27. doi:https://doi.org/10.1167/iovs.64.5.27

Znf469 Plays a Critical Role in Regulating Synthesis of ECM: A Zebrafish Model of Brittle Cornea Syndrome Open Access

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Jing Bao; Xiaoning Yu; Xiyuan Ping; Xingchao Shentu; Jian Zou

Tags: cornea, ehlers-danlos syndrome 6b, mutation, zebrafish, regulation

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 29. doi:https://doi.org/10.1167/iovs.64.5.29

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Myofiber Type Shift in Extraocular Muscles in Amyotrophic Lateral Sclerosis Open Access

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Arvin Behzadi; Anton Erik Tjust; Jing-Xia Liu; Peter Munch Andersen; Thomas Brännström; Fatima Pedrosa Domellöf

Tags: amyotrophic lateral sclerosis, antibodies, donors, muscle of orbit, synaptophysin

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 15. doi:https://doi.org/10.1167/iovs.64.5.15

Genetics

Familial Whole Exome Sequencing Study of 30 Families With Early-Onset High Myopia Open Access

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Entuan Yang; Jifeng Yu; Xue Liu; Huihui Chu; Li Li

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 10. doi:https://doi.org/10.1167/iovs.64.5.10

Glaucoma

Myopic Versus Glaucomatous Parapapillary Beta Zone in Myopic Eyes Versus Eyes With Secondary Angle-Closure Glaucoma Open Access

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Jost B. Jonas; Rahul A. Jonas; Shefali B. Jonas; Songhomitra Panda-Jonas

Tags: angle closure glaucoma, eye, glaucoma, retinal pigment cell

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 25. doi:https://doi.org/10.1167/iovs.64.5.25

Neuroretinal Rim Response to Transient Intraocular Pressure Challenge Predicts the Extent of Retinal Ganglion Cell Loss in Experimental Glaucoma Open Access

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Nimesh B. Patel; Louvenia Carter-Dawson; Laura J. Frishman

Tags: glaucoma, intraocular pressure, diagnostic imaging, eye, optic disk

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 30. doi:https://doi.org/10.1167/iovs.64.5.30

Immunology and Microbiology

The Diagnostic Value of Triggering Receptor Expressed on Myeloid Cells-1 in Post-Traumatic Bacterial Endophthalmitis Open Access

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Qiuyang Tang; Mengxuan He; Shudan Zhang; Junfang Zhang; Ling Yang; Haihong Shi

Tags: bacterial endophthalmitis, endophthalmitis, triggering receptor expressed on myeloid cells-1, mass or substance concentration per volume, vitreous body

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 4. doi:https://doi.org/10.1167/iovs.64.5.4

Staphylococcal Enterotoxins Promote Virulence in Bacterial Keratitis Open Access

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William L. Johnson; Michael Sohn; Collynn F. Woeller; Rachel A. F. Wozniak

Tags: enterotoxins, keratitis, virulence, staphylococcal enterotoxins, bacterial keratitis

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 5. doi:https://doi.org/10.1167/iovs.64.5.5

Altered Functionality of Lipoprotein(a) Impacts on Angiogenesis in Diabetic Retinopathy Open Access

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Mahnaz Shariatzadeh; Nicole M. A. Nagtzaam; Leonie van Vark-van der Zee; Conny van Holten-Neelen; Adrie J. M. Verhoeven; Jonas Dehairs; Johannes V. Swinnen; Frank Leijten; Josianne C. ten Berge; Jose P. Martinez Ciriano; King T. Wong; Monique Mulder; Pieter J. M. Leenen; Willem A. Dik

Tags: angiogenesis, diabetes mellitus, type 2, diabetic retinopathy, lipoproteins, low-density lipoproteins

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 8. doi:https://doi.org/10.1167/iovs.64.5.8

Metagenomic Sequencing Analysis Identifies Cross-Cohort Gut Microbial Signatures Associated With Age-Related Macular Degeneration Open Access

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Wei Xue; Peiyao Peng; Xiaofeng Wen; Huan Meng; Yali Qin; Tingting Deng; Shixin Guo; Tingting Chen; Xifang Li; Juanran Liang; Feng Zhang; Zhi Xie; Ming Jin; Qiaoxing Liang; Lai Wei

Tags: age-related macular degeneration, cohort studies, datasets, dysbiosis, microbiome

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 11. doi:https://doi.org/10.1167/iovs.64.5.11

Identification of Hif1α as a Potential Participant in Autoimmune Uveitis Pathogenesis Using Single-Cell Transcriptome Analysis Open Access

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Lei Zhu; He Li; Rong Wang; Zhaohuai Li; Sichen Zhao; Xuening Peng; Wenru Su

Tags: autoimmunity, mice, pathogenesis, regulatory t-lymphocytes, single-cell gene expression analysis

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 24. doi:https://doi.org/10.1167/iovs.64.5.24

Physiology and Pharmacology

Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization Open Access

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Nan Shu; Zhi Zhang; Xiaotang Wang; Ruonan Li; Wanqian Li; Xianyang Liu; Qi Zhang; Zhengxuan Jiang; Liming Tao; Li Zhang; Shengping Hou

Tags: autoimmunity, microglia, uveitis, toll-like receptor 4, western blotting

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 21. doi:https://doi.org/10.1167/iovs.64.5.21

Retina

Kamuvudine-9 Protects Retinal Structure and Function in a Novel Model of Experimental Rhegmatogenous Retinal Detachment Open Access

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Peirong Huang; Claire C. Thomas; Kameshwari Ambati; Roshni Dholkawala; Ayami Nagasaka; Praveen Yerramothu; Siddharth Narendran; Felipe Pereira; Yosuke Nagasaka; Ivana Apicella; Xiaoyu Cai; Ryan D. Makin; Joseph Magagnoli; Cliff I. Stains; Ruwen Yin; Shao-bin Wang; Bradley D. Gelfand; Jayakrishna Ambati

Tags: retina, retinal detachment, rhegmatogenous retinal detachment, mice

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 3. doi:https://doi.org/10.1167/iovs.64.5.3

Optical Coherence Tomography Angiography of Volumetric Arteriovenous Relationships in the Healthy Macula and Their Derangement in Disease Open Access

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Janice X. Ong; Ghazi O. Bou Ghanem; Peter L. Nesper; Jessica Moonjely; Amani A. Fawzi

Tags: angiogram, arteriole, blood capillaries, eye, large blood vessels

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 6. doi:https://doi.org/10.1167/iovs.64.5.6

Microglial CD11b Knockout Contributes to Axonal Debris Clearance and Axonal Degradation Attenuation via IGF-1 After Acute Optic Nerve Injury Open Access

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Jiaxing Zhou; Sen Lin; Qiumei Hu; Xue Li; Xi Chen; Linlin Luo; Shiyang Ye; Wei Liu; Jian Ye

Tags: insulin-like growth factor i, macrophage-1 antigen, microglia, phagocytosis, optic nerve injuries

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 7. doi:https://doi.org/10.1167/iovs.64.5.7

Progression Biomarkers of Microvascular and Photoreceptor Changes Upon Long-Term Evaluation in Type 1 Diabetes Open Access

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Serena Fragiotta; Eliana Costanzo; Fabiana Picconi; Paola Giorno; Daniele De Geronimo; Daniela Giannini; Simona Frontoni; Monica Varano; Mariacristina Parravano

Tags: biological markers, chief complaint, diabetes mellitus, type 1, photoreceptors, parafoveal region

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 23. doi:https://doi.org/10.1167/iovs.64.5.23

Retinal Cell Biology

Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease Open Access

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Mark L. Derbyshire; Sruti Akula; Austin Wong; Karisa Rawlins; Evelyn B. Voura; William J. Brunken; Michael E. Zuber; Sabine Fuhrmann; Anne M. Moon; Andrea S. Viczian

Tags: angiogenesis, eye, mice, retina, astrocytes

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 1. doi:https://doi.org/10.1167/iovs.64.5.1

Spatiotemporal Coordination of RPE Cell Quality by Extracellular Vesicle miR-494-3p Via Competitive Interplays With SIRT3 or PTEN Open Access

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Junji Hamuro; Tomoko Yamashita; Yohei Otsuki; Nao Hiramoto; Mayuka Adachi; Takafumi Miyatani; Hiroshi Tanaka; Morio Ueno; Shigeru Kinoshita; Chie Sotozono

Tags: idiopathic pneumonia syndrome, mitochondria, pten gene, retinal pigment cell, extracellular vesicles

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 9. doi:https://doi.org/10.1167/iovs.64.5.9

Differential Eye Expression of Xenopus Acyltransferase Gnpat and Its Biochemical Characterization Shed Light on Lipid-Associated Ocular Pathologies Open Access

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Gabriel E. Bertolesi; Maxwell F. J. Chilije; Victoria Li; Chase C. Thompson; Arturo López-Villalobos; Carrie L. Hehr; Karen Atkinson-Leadbeater; Vanina Zaremberg; Sarah McFarlane

Tags: acyltransferase, eye, lipids, proteins, xenopus

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 17. doi:https://doi.org/10.1167/iovs.64.5.17

Visual Neuroscience

Despite Impaired Binocular Function, Binocular Disparity Integration Across the Visual Field Is Spared in Normal Aging and Glaucoma Open Access

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Guido Maiello; MiYoung Kwon

Tags: glaucoma, health disparity, spatial frequency, visual fields, vision disparity

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 2. doi:https://doi.org/10.1167/iovs.64.5.2

Visual Psychophysics and Physiological Optics

Perceptual Center-Surround Contrast Suppression in Adolescence Open Access

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Bao N. Nguyen; Bhavatharini Ramakrishnan; Anuradha Narayanan; Jameel R. Hussaindeen; Allison M. McKendrick

Tags: adolescent, adult, perception

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 14. doi:https://doi.org/10.1167/iovs.64.5.14

Review

Mechanisms of Acquired Resistance to Anti-VEGF Therapy for Neovascular Eye Diseases Open Access

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Dhyana Sharma; Ian Zachary; Haiyan Jia

Tags: anti-vascular endothelial growth factor therapy, eye diseases, neuropilin-1, vascular endothelial growth factor a, glycolysis

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 28. doi:https://doi.org/10.1167/iovs.64.5.28

Letters to the Editor

Author Response: The Posterior Displacement of the Bruch's Membrane Opening: A Surprising Finding in Spaceflight-Associated Neuro-Ocular Syndrome Open Access

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Patrick A. Sibony; Steven S. Laurie; Connor R. Ferguson; Laura P. Pardon; Millennia Young; F. James Rohlf; Brandon R. Macias

Tags: bruch's basal membrane, spaceflight-associated neuro-ocular syndrome

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 19. doi:https://doi.org/10.1167/iovs.64.5.19

The Posterior Displacement of the Bruch's Membrane Opening: A Surprising Finding in Spaceflight-Associated Neuro-Ocular Syndrome Open Access

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Peter Wostyn; C. Robert Gibson; Thomas H. Mader

Tags: bruch's basal membrane, spaceflight-associated neuro-ocular syndrome

Investigative Ophthalmology & Visual Science May 2023, Vol.64, 20. doi:https://doi.org/10.1167/iovs.64.5.20

Erratum

Erratum in: IMI—Global Trends in Myopia Management Attitudes and Strategies in Clinical Practice—2022 Update Open Access

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Investigative Ophthalmology & Visual Science May 2023, Vol.64, 12. doi:https://doi.org/10.1167/iovs.64.5.12

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