Volume 64 Issue 8 | IOVS

Regulation of cell death by the pseudoprotease cFLIP Open Access

Kim Newton

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1. doi:

Targeting protein kinase G for the treatment of degenerative diseases of the retina Open Access

Francois Paquet-Durand

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 2. doi:

Genotype- and phenotype-specific altered proteins in human retinal pigment epithelium: Insight into cell death with AMD Open Access

Deborah A Ferrington

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 3. doi:

Neutrophil activation and cell death in Pseudomonas aeruginosa keratitis Open Access

Eric Pearlman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 4. doi:

Pro-degenerative SARM1 as an immune-modulator in retinal degenerative disease Open Access

Sarah L Doyle

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 5. doi:

Mechanisms of RPE cell death Open Access

Shusheng Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 6. doi:

Probing of Light evoked Retinal response: photoreceptors and beyond Open Access

Clara Pfäffle

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 7. doi:

Studying cone phototransduction in vivo via optoretinography Open Access

Ramkumar Sabesan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 8. doi:

Water permeability of the RPE and Choriocapillaris and its role in the Optoretinogram (ORG) Open Access

Edward N. Pugh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 9. doi:

Impaired cone function in regions with outer retina structural degradation measured with phase-sensitive AO-OCT Open Access

Zhuolin Liu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 10. doi:

Visualizing retinal ganglion cell activity in the living primate using adaptive optics calcium imaging Open Access

Juliette E McGregor

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 11. doi:

Applications of two-photon excitation in probing of retinal function Open Access

Maciej D. Wojtkowski

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 12. doi:

Two-photon excited fluorescence lifetime ophhalmoscopy Open Access

Jennifer J. Hunter

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 13. doi:

Remaining key questions in myopia control treatments, including importance of studying diverse populations Open Access

Padmaja Sankaridurg

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 14. doi:

Current hypotheses and unknowns on the mechanisms of myopia development and myopia progression Open Access

Frank Schaeffel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 15. doi:

Introduction to myopia control treatments including optical, light and pharmacological treatments Open Access

Kate Gifford

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 16. doi:

Currently proposed mechanisms and remaining unknowns for optical myopia control treatment – not just peripheral defocus. Open Access

Linda Lundstrom

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 17. doi:

Currently proposed mechanisms and remaining unknowns for pharmacological treatments, with a focus on low dose atropine eye drops Open Access

Regan Ashby

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 18. doi:

Currently proposed mechanisms and remaining unknowns for environmental factors, including time outdoors and effects of light: Objective measures and behavioral modifications solutions Open Access

Lisa Ostrin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 19. doi:

Currently proposed mechanisms and remaining unknowns for near work. Objective measures and behavioral modifications solutions. Open Access

Norberto Lopez-Gil

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 20. doi:

Monocular transcorneal electrical stimulation induces thickening of contralateral ciliary muscle Open Access

Sandra Wagner; Esra Süer; Bishesh Sigdel; Torsten Strasser

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 21. doi:

Inner limiting membrane (ILM) peel extends in vivo calcium imaging of retinal ganglion cell (RGC) activity beyond the fovea in non-human primate Open Access

Hector C Baez; Jennifer M. LaPorta; Amber D. Walker; William S. Fischer; Rachel Hollar; Sara Patterson; David Allen DiLoreto; Vamsi Gullapalli; Juliette E McGregor

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 22. doi:

Rodent retinal ganglion cells contain relatively high levels of signal recognition particle and endoplasmic reticulum to support expression of integral-membrane and secreted proteins Open Access

Sumathi Shanmugam; Phillip E Kish; Dejuan Kong; Heather Hager; Steven F Abcouwer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 23. doi:

Dynamics of pupil response recovery in patients with mild Traumatic Brain Injury Open Access

Ashwin Badrinath Pothiadia Irungovel; Myoung Hee Esther Han; Andrew TE Hartwick; Suresh Viswanathan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 24. doi:

Function and morphology of ipRGCs is preserved in the aging mouse retina Open Access

Luis Perez de Sevilla Muller; Brandy S. Recio; Zachary Myers; Sachin Parikh; Rajesh Kumar Goit; Nicholas Brecha; Anna Matynia

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 25. doi:

Nitric oxide mediates differential effects in mouse retinal ganglion cells Open Access

Dominic Gonschorek; Tom Schwerd-Kleine; Jonathan Oesterle; Zhijian Zhao; Timm Schubert; Thomas Euler

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 26. doi:

A New Technique to Quantify Pupil Responses from Melanopsin Ganglion Cells Open Access

JEFFREY C RABIN; Frances Silva; Loary Inclan; Harper Gillentine; Natalie Trevino; Liqing Li; Gary Anderson; Erica Lee; Harrison Vo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 27. doi:

Summation of responses from stimulated cone pairs in macaque V1 neurons Open Access

Cyril N.A NYANKERH; Philipp Tellers; Keaton Ramsey; Alexander Meadway; Lawrence Sincich

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 28. doi:

Measuring the precision of spot localization in the population code of retinal ganglion cells. Open Access

Zach Jessen; Nataliia Martyniuk; Samuele Virgili; Krishna Dovzhik; Ulisse Ferrari; Olivier Marre; Greg Schwartz; Petri Ala-Laurila

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 29. doi:

Different contrast response functions for sawtooth stimulation favoring ON vs OFF visual pathways in the upper and lower visual fields. Open Access

Martin Timothy Wilkinson Scott; Alexandra Yakovleva; Anthony Matthew Norcia

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 30. doi:

Chemical ablation of rod/cone photoreceptors reveals distinct cellular mechanisms for the pupillary light reflex across light levels Open Access

Jeremy M Bohl; Megi Kola; Zachary Sharpe; Angela Shehu; Tomomi Ichinose

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 31. doi:

A novel role for mechanistic target of rapamycin complex 2 in visual function Open Access

Dejuan Kong; Heather Hager; Sumathi Shanmugam; Steven F Abcouwer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 32. doi:

Relationship between subjective spherical power and estimated power by SSVEP Open Access

Tamio Sahashi; Yukito Hirayama; Arao Funase

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 33. doi:

MafB labels novel Amacrine and Retinal Ganglion Cell subtypes in the mouse retina Open Access

Nina Hong Luong; Benjamin Sivyer; Kevin Wright

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 34. doi:

Cdh13 Regulates Wide-Field Neuron Spine Morphogenesis in the Superior Colliculus Open Access

Angela Matcham; Xin Duan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 35. doi:

Amblyopic fixation stability differentially affects monocular and dichoptic contrast sensitivity Open Access

Mirella Telles Salgueiro Barboni; Otto Maneschg; János Németh; Zoltán Zsolt Nagy; Éva Bankó

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 36. doi:

Retinotopic organisation of dLGN-projecting ipRGCs in the mouse Open Access

Rose Richardson; Marina Gardasevic; Lucy Holmes; Jonathan Wynne; Annette Allen; Nina Milosavljevic; Robert Lucas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 37. doi:

COMPARISON OF HIGH THROUGHPUT RECEPTIVE FIELD MAPPING APPROACHES FOR HIGH DENSITY ELECTROPHYSIOLOGY IN MICE Open Access

Juan Gabriel Santiago Moreno; Daniel J Denman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 38. doi:

Early History of Monocular Deprivation Reduces the Capacity for Subsequent Neural Plasticity in the Cat Lateral Geniculate Nucleus Open Access

Mark Henneberry; Joseph Elgallad; Seth Gordon Smith; Kevin R Duffy

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 39. doi:

Anesthetic disruption of visual evoked feedforward and feedback signaling in the mouse brain Open Access

Adeeti Aggarwal; Jennifer Luo; Diego Contreras; Max Kelz; Alex Proekt

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 40. doi:

Establishing a mouse model of cerebral/cortical visual impairment (CVI) Open Access

Dana K Oakes; Jun Cai; Aaron W McGee; William Guido

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 41. doi:

D1R AND D4R AGONISTS MODIFY LIGHT-EVOKED WHOLE-RETINA RECORDINGS Open Access

Angela MacIsaac; Kyle Filicetti; Andrea Wellington; Erika D Eggers

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 42. doi:

Eyetracking-enhanced VEP for nystagmus Open Access

Perry Carter; Fatima Shawkat; James Self; Helena Lee; Eloise Keeling; Matt Dunn

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 43. doi:

Morphological identification of novel functional ganglion and amacrine cell types in macaque retina Open Access

Alexandra Kling; Michael B. Manookin; Fred Rieke; Sam Cooler; Alexander Sher; Alan Litke; E.J. Chichilnisky

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 44. doi:

Object-background segregation in mouse retinal ganglion cells Open Access

Chenchen Cai; Thomas Euler; Katrin Franke

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 45. doi:

An instructive role for experience in the developing mouse visual thalamus Open Access

Takuma Sonoda; Chinfei Chen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 46. doi:

Altered trajectory of visual circuit maturation in the superior colliculus of fragile X mice Open Access

Jason W Triplett; Karen G Dixon; Ashley L Russell

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 47. doi:

Now you see it. Now you don’t. Visual perceptual learning occurs during ultrasound training but is quickly lost without continued experience. Open Access

Olivia Mescher; Cassidy Musick; Randal Anderson; Anthony C Pappas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 48. doi:

Reduction of High Spatial Frequency Tuning in Visual Cortex Correlates with Impaired Visual Acuity in a Murine Model of Retinitis Pigmentosa Open Access

thomas Christopher brown; Cecilia Attaway; Aaron W McGee

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 49. doi:

Development of a Schlemm’s Canal “Inner Wall on a Chip” for High Content Screening Open Access

Seyed Mohammad Siadat; Jacques A Bertrand; Darryl R Overby; W Daniel Stamer; C Ross Ethier

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 50. doi:

Abnormalities in cholesterol homeostasis may contribute to pathogenesis of pseudoexfoliation syndrome/glaucoma. Open Access

Matthias Zenkel; Dieter Lütjohann; Anja Kerksiek; Andreas Giessl; Friedrich E. Kruse; Ursula Schlötzer-Schrehardt

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 51. doi:

Orexin A Expression in the Glaucomatous Tree Shrew Brain Open Access

Arthur DeCarlo; Dan Shan; Brian C. Samuels

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 52. doi:

Mechanistic insights gained from glaucomatous human primary trabecular meshwork cells treated with implant levels of bimatoprost Open Access

Daniel Nicolae Mitroi; Sara Cabrera-Ghayouri; Justyna Resztak; Jacob Degner; Sabah Kadri; Anneke I. den Hollander; Daniel W Stamer; Mohammed Dibas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 53. doi:

The Influence of Experimental Environment on the Mechanical Properties of Porcine Iris Stroma Using Micro-Indentation Open Access

Frederick Sebastian; Gabrielle Bailey; Vineel Kondiboyina; Syril Dorairaj; Rouzbeh Amini

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 54. doi:

Long-Term Remodeling of the Lamina Cribrosa After Pressure Lowering by Suturelysis Open Access

Cameron A Czerpak; Harry A Quigley; Thao Nguyen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 55. doi:

Biochemical Dissection of Pseudoexfoliative Glaucoma Deposit Formation Open Access

Anna Mueller; Vanessa Collao; Richard K Lee; Anna K Junk; Sanjoy K Bhattacharya

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 56. doi:

TRPV4 regulates cytoskeletal and extracellular matrix remodeling in Schlemm’s canal cells Open Access

Haiyan Li; Cydney Wong; Kristin Marie Perkumas; W Daniel Stamer; Todd Sulchek; C Ross Ethier

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 57. doi:

The influence of axial length on ocular rigidity in open-angle glaucoma Open Access

Diane N Sayah; Denise Descovich; Santiago Costantino; Mark Lesk

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 58. doi:

More peripapillary sclera (PPS) collagen fibers straighten than lamina cribrosa (LC) fibers before reaching 10% bundle stretch Open Access

Po-Yi Lee; Gosia Fryc; John Gnalian; Yi Hua; Susannah Waxman; Fuqiang Zhong; Bin Yang; Ian A Sigal

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 59. doi:

Delineating the Role of Soluble Epoxide Hydrolase in the Aging Retina Open Access

Caroline Manicam; Elahe Zare; Mario Dejung; Falk Butter; Franz Grus; Norbert Pfeiffer; Natarajan Perumal

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 60. doi:

Variations in lamina cribrosa insertions into the sclera may contribute to regional differences in neural tissue damage and sensitivity to elevated intraocular pressure Open Access

Fengting Ji; Po Lam; Bryn L Brazile; Yi Hua; Ian A Sigal

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 61. doi:

Non-invasive infrared spectroscopy of aqueous humour samples in glaucoma compared to controls Open Access

Neeru Amrita Vallabh; Cassio Lima; Hannah Levis; Hussameddin Muntasser; Stephen Kaye; Royston Goodacre

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 62. doi:

Lamina Cribrosa Deformation Response to Pressure Lowering by Glaucoma Medication Open Access

Thao Nguyen; Vanessa Hannay; Cameron A Czerpak; Harry A Quigley

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 63. doi:

Estrogen signaling, trabecular meshwork, and intraocular pressure regulation Open Access

Yutao Liu; Hannah Youngblood; Jingwen Cai; Jason Sun; Hongfang Yu; Patricia Schoenlein; Hongyan Xu; Sylvia B Smith

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 64. doi:

Peripapillary scleral flange experiences high mechanical strains during intraocular pressure elevation Open Access

Sunny Kwok; Jun Liu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 65. doi:

Overexpression of endothelin-1 elicits phenotypes of reactive astrocytosis and elastinopathy in primary optic nerve astrocytes Open Access

Simon Kaja; Anita K. Ghosh; Jamie Floss; Bronte Root; Candace Betancourt-Szymanowska; Vidhya R Rao

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 66. doi:

Biomechanical correlations between cornea and optic nerve head Open Access

Manqi Pan; Sunny Kwok; Xueliang Pan; Jun Liu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 67. doi:

Iris Morphological and Biomechanical Factors Influencing Angle Closure During Pupil Dilation Open Access

Royston K.Y. Tan; Gim Yew Ng; Tun Aung Tin; Fabian Albert Braeu; Monisha Esther Nongpiur; Tin Aung; Michael J A Girard

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 68. doi:

Eyes with High Myopia Experience Greater Gaze-induced Optic Nerve Head Deformations Compared to Normal Eyes Open Access

Tingting Liu; Ya Xing Wang; Donny QV Hoang; Michael J A Girard; Xiaofei Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 69. doi:

A study of the glaucoma-linked E50K mutation of Optineurin and its crosstalk with the ubiquitin-proteasome system Open Access

Alessandra Boccaccini; Dario Cavaterra; Grazia Tundo; Diego Sbardella; Francesco Oddone

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 70. doi:

Intraocular Pressure Correlates with Increased c-Fos Immunoreactivity in the Thalamic Paraventricular Nucleus in a Rat Model Open Access

Kevin Graciano; Arthur DeCarlo; Massimo A Fazio; Brian C. Samuels

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 71. doi:

Intracameral Pressure Comparison to Goldmann and Modified Goldmann Tonometry in both Normal Cadaveric Eyes and Cadaveric Eyes Which Underwent Myopic Laser in situ Keratomileusis Open Access

Sean Joseph McCafferty

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 72. doi:

The Role of Piezo1 in Lamina Cribrosa (LC) Fibrosis in Glaucoma Open Access

Amy Coman; Mustapha Irnaten; Colm J O'Brien

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 73. doi:

A Method to Recover Tissue Biomechanical Properties from Noisy Optical Coherence Tomography Measurements Via Coupled Optical and Mechanical models Open Access

George Barbastathis; Ziling Wu; Fabian Albert Braeu; Michael J A Girard

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 74. doi:

Viscoelastic Biomechanical Modeling of the Human Optic Nerve Head Open Access

J Crawford C Downs; Reza Razaghi; Seyed Mohammadali Rahmati; Christopher A Girkin; Alireza Karimi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 75. doi:

ALTERED PROCESSING OF MYOCILIN THROUGH THE UBIQUITIN-PROTEASOME SYSTEM INTRODUCES THE FIRST PROFILING OF THE GLOBAL UBIQUITYLOME OF TRABECULAR MESHWORK CELLS IN A GLAUCOMA MODEL Open Access

Diego Sbardella; Grazia Raffaella Tundo; Alessandra Boccaccini; Dario Cavaterra; Giulia Coco; Sara Giammaria; Irene Pandino; Gabriele Antonio Zingale; Gianluca Manni; Massimo Coletta; Francesco Oddone

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 76. doi:

miRNA Profiling of Lamina Cribrosa Cells Between European and African Descent Individuals Open Access

Tara Tovar-Vidales; Navita Lopez; Rajiv Rangan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 77. doi:

CAI-augmented macular pigment supplementation improves visual acuity and contrast sensitivity in eyes with pericentral glaucomatous visual field loss Open Access

Truong Vu; Megan Schillerstrom; William Sponsel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 78. doi:

Exploring the role of microbial by-product, butyrate, on the fibrotic trabecular meshwork Open Access

Jose Ricardo Ramirez; Thanh Le; Humberto Hernandez

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 79. doi:

Expression of microRNAs 146b-5p and 146b-3p in Human Optic Nerve Head Astrocytes Exposed to Stretch Open Access

Rajiv Rangan; Abbot F Clark; Tara Tovar-Vidales

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 80. doi:

Investigating the role of toll-like receptors and signaling molecules in POAG Open Access

Thanh Le; Jose Ricardo Ramirez; Morgen Glenn; Colleen M McDowell; Humberto Hernandez

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 81. doi:

INCREASED UBIQUITYLATION OF β-TrCP SUBUNIT OF SCF E3-LIGASE IN PERIPHERAL BLOOD MONONUCLEAR CELLS OF GLAUCOMA SUBJECTS: A PROTEOMIC STUDY Open Access

Gabriele Antonio Zingale; Grazia Raffaella Tundo; Alessandra Boccaccini; Dario Cavaterra; Sara Giammaria; Irene Pandino; Gianluca Manni; Massimo Coletta; Francesco Oddone; Diego Sbardella

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 82. doi:

Quantification of clinically-relevant biomarkers in primary human trabecular meshwork (TM) cells and human retinal pigment epithelium (ARPE-19) cells following exposure to mechanical stra... Open Access

Azza Dammak; Sana Iqbal; Vidhya R Rao; Gonzalo Carracedo; Simon Kaja

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 83. doi:

Tensile properties of sclera, optic nerve, and optic nerve sheath in humans with glaucoma Open Access

Immi Lee; Joseph Park; Somaye Jafari; Joseph L Demer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 84. doi:

A Case-control study of primary vascular risk factors for normal tension glaucoma Open Access

Elan Meltzer; Jeffrey Hanover; Daniela Yakobashvili; Albert S. Khouri

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 85. doi:

Race and Age-based Prevalence Patterns of Glaucoma in the IRIS^®Registry (Intelligent Research in Sight) Open Access

Natasha Nayak Kolomeyer; Maurizio Tomaiuolo; Louis R Pasquale; Young Sheng; Leslie Hyman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 86. doi:

Associations between Use of Cholesterol Medications and Glaucoma in the National Institutes of Health All of Us Research Program Open Access

Samuel Lee; Megan E. Paul; Ken Kitayama; Victoria L Tseng; Fei Yu; Deyu Pan; Anne L Coleman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 88. doi:

Coffee and tea intake and the risk of open-angle glaucoma in a population-based study Open Access

Wishal Ramdas; Joëlle Vergroesen; Sara Baart; Trudy Voortman; Caroline C W Klaver

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 89. doi:

ASSOCIATION BETWEEN ULTRA-PROCESSED FOOD CONSUMPTION AND THE INCIDENCE OF GLAUCOMA: THE SUN COHORT Open Access

Javier Moreno-Montanes; José Francisco López-Gil; Maria S Hershey; Laura Moreno-Galarraga; Maira Bes-Rastrollo; Alejandro Fernández-Montero

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 90. doi:

Dietary nitrate and iron intake in a population at high-risk of primary open angle glaucoma Open Access

Sjoerd Jan Driessen; Doreen Nelson-Ayifah; Angelina Ampong; Coert J. Ridderhof; Caroline C W Klaver; Pieter Bonnemaijer; Alberta A H J Thiadens

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 91. doi:

The associations between glaucoma, glaucoma severity and circadian rhythm sleep disorders in California Medicare beneficiaries Open Access

Martin Ramirez; Ken Kitayama; Fei Yu; Victoria L Tseng; Anne L Coleman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 92. doi:

Effect of obstructive sleep apnea on rates of structural loss in glaucoma over time Open Access

Vahid Ownagh; Alessandro Jammal; Davina Malek; Asmaa Ahmed Ali Youssif; Felipe A Medeiros

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 93. doi:

Serum vitamins and retinal nerve fiber layer changes on SD-OCT: the Alienor study Open Access

Benedicte MJ Merle; Marie-Bénédicte Rougier; Catherine Feart; Melanie Le Goff; Laure Gayraud; Marie-Noelle Delyfer; Cedric Schweitzer; Cecile Delcourt

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 94. doi:

Determinants of retinal nerve fibre loss in an aging cohort Open Access

Ammar Alhadi; Zakariya Jarrar; Christopher J Hammond; Abdus Samad Ansari

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 96. doi:

Intra-Ocular Pressure Change with age in Early Adult Life. Open Access

David Mackey; Gareth Lingham; Samantha Sze-Yee Lee

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 97. doi:

Alcohol consumption, genetic risk, and intraocular pressure and glaucoma: The Canadian Longitudinal Study on Aging Open Access

Alyssa Grant; Marie-Hélène Roy-Gagnon; Joseph Bastasic; Akshay Talekar; Mahsa Jessri; Gisele Li; Ralf Buhrmann; Ellen E Freeman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 98. doi:

The clinical utility of a glaucoma polygenic risk score in four European-ancestry cohorts Open Access

Victor Anthony de Vries; Akiko Hanyuda; Joëlle Vergroesen; Ron Do; David S Friedman; Peter Kraft; Yuyang Luo; Jessica Tran; Sze H Wong; Nazlee Zebardast; Caroline C W Klaver; Janey L Wiggs; Ayellet V. Segre; Jae H Kang; Wishal Ramdas; Louis R Pasquale

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 99. doi:

Whole-exome Sequencing Identifies Rare Variants and Genes Associated with Glaucoma Open Access

Marion Chiariglione; Alexander J. Arch; XIaoyi R. Gao

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 100. doi:

Analysis of the Incidence and Risk Factors Associated with the Development of Glaucoma and Ocular Hypertension Following Congenital Cataract Surgery Open Access

Ana Roldan; Rucha Borkhetaria; Amanda Ely

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 101. doi:

Racial, ethnic, and socioeconomic disparities in glaucoma onset and severity in a diverse nationwide cohort Open Access

Kaela Acuff; Bharanidharan Radha Saseendrakumar; Jo-Hsuan Wu; Robert N Weinreb; Sally Baxter

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 102. doi:

Risk Factors for Developing Severe Visual Impairment Due to Glaucoma in the Bascom Palmer Glaucoma Repository Open Access

Swarup Sai Swaminathan; Robert O'Brien; Steven J Gedde

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 103. doi:

Prediction model of visual field progression in the Ocular Hypertension Treatment Study Open Access

Mae O Gordon; Dale K Heuer; Eve J Higginbotham; Richard K Parrish; Chris A Johnson; Lei Liu; Michael A Kass

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 104. doi:

The Impact of Demographics on Regional Visual Field Loss and Worsening in Glaucoma Open Access

Yueyin Pang; Melody Tang; Min Shi; Tobias Elze; Louis R Pasquale; Nazlee Zebardast; David S. Friedman; Michael Boland; Lucy Q. Shen; Mengyu Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 105. doi:

The Impact of Marital Status on Visual Field Loss and Worsening in Glaucoma Open Access

Pingping Zhao; Louis R Pasquale; Lucy Q. Shen; Tobias Elze; Mengyu Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 106. doi:

Severity of Glaucomatous Visual Field Defects and Self-reported Driving Difficulty in a Japanese Population Open Access

Yoshiko Ofuji; Akiko Hanyuda; Kenya Yuki; Natsumi Takizawa; Motohiro Moriya; Daisuke Shiba; Kazuno Negishi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 107. doi:

Follow-up of Eyes Developing Severe Visual Impairment Due to Glaucoma in the Bascom Palmer Glaucoma Repository Open Access

Varun Krishnan; Steven J Gedde; Swarup S. Swaminathan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 108. doi:

Perimetry Certification Provided by a Reading Center Improves Quality of Data Collection in Clinical Trials Open Access

Edeleidys Sanchez Saucedo; Maria Parker; Audra Miller; Shobana Aravind; Hiroshi Ishikawa

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 109. doi:

The Association between Glaucoma Severity and Hip Fractures in California Medicare Beneficiaries Open Access

Sayan Chatterjee; Ken Kitayama; Andrew G. Young; Fei Yu; Victoria L Tseng; Anne L Coleman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 110. doi:

The Association between Glaucoma and Motor Vehicle Accidents in California Medicare Beneficiaries Open Access

Ricardo Oregon Guzman; Ken Kitayama; Fei Yu; Victoria L Tseng; Anne L Coleman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 111. doi:

Health disparities in glaucoma management: Revealing a racial divide in visual field testing Open Access

Chisom T. Madu; TingFang Lee; Vikram Paranjpe; Ashley Sohn; Jiyuan Hu; Jonathan Fam; Andrew Wronka; Eleanore T. Kim; Gadi Wollstein; Joel S Schuman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 112. doi:

Nationwide aggregation of glaucoma surgeries in fiscal years 2014 and 2020 in Japan Open Access

Masaki Tanito

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 113. doi:

The Effect of Myopia on Glaucoma Surgery in California Medicare Beneficiaries with Primary Open Angle Glaucoma Open Access

Melissa Yao; Ken Kitayama; Fei Yu; Victoria L Tseng; Anne L Coleman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 114. doi:

Prevalence of and Risk Factors Associated with Undetected Open-Angle Glaucoma in African Americans: The African American Eye Disease Study (AFEDS) Open Access

Nathan Dhablania; Mina Torres; Bruce Burkemper; Roberta McKean-Cowdin; Rohit Varma

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 115. doi:

Jamaica Eyes: Establishing a Robust Clinical Profile of a Unique Afro-Caribbean Population with High Glaucoma Rates Open Access

Jessica Cooke Bailey; Kaitlyn Funk; Briana McIntosh; Camara Brown

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 116. doi:

Access to Vision Care and Prevalence of Glaucoma in the National Institutes of Health “All of Us” Database Open Access

Megan E. Paul; Victoria L Tseng; Ken Kitayama; Fei Yu; Anne L Coleman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 117. doi:

An electronic medical record-based approach to predict loss to follow-up in patients with open-angle glaucoma Open Access

Arjun Sharma; Shiyoung Roh; David J Ramsey

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 118. doi:

Eye care utilization and visual outcomes among glaucoma patients in the Intelligent Research in Sight Registry from 2015 – 2020 Open Access

Elizabeth Ciociola; Sayuri Sekimitsu; Sophie Smith; Alice Lorch; Joan W Miller; Tobias Elze; Nazlee Zebardast

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 119. doi:

Impact of psychometric measures on adherence patterns to ocular hypotensive therapy in patients with primary open-angle glaucoma Open Access

Swetha Ravichandran; Shervonne Poleon; Lyne Racette

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 120. doi:

Improved glaucoma medication access through pharmacy partnership to minimize out-of-pocket costs: A single institution experience Open Access

Jin Choi; Pathik Amin; Alaina Tarantino; Mary Qiu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 121. doi:

De-insured routine eye exams and associated increased use of family physicians and ophthalmologists for glaucoma diagnosis Open Access

Wongel Bogale; Graham E Trope; Noah M Ivers; Yvonne M Buys; Yaping Jin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 122. doi:

Assessing Participant Confidence about Their Glaucoma After Using an Online Support Community Open Access

Corinne Shiu; Yury Salazar Smith; Kira Baldonado; Nita Sinha; Yvonne Ou

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 123. doi:

Cost-effectiveness of Artificial Intelligence-aided Glaucoma Screening in Hong Kong: A Markov Model Open Access

Anran RAN; Poemen Pui Man Chan; Clement C. Tham; Carol Yim-lui Cheung

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 124. doi:

Critical limits for differentiating glaucoma-suspect and non-suspect eyes in Swedish patients Open Access

Konstancija Kisonaite; Albert Alm; Eva Nuija; Zhaohua Yu; Tolga Tümer; Konstantin Galichanin; Per G Soderberg

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 125. doi:

Manhattan Vision Screening and Follow-up Study (NYC-SIGHT) Cluster-Randomized Clinical Trial: Subanalysis of Glaucoma Suspect Findings Open Access

Stefania C Maruri; Qing Wang; Ives Valenzuela; Noga Harizman; Prakash Gorroochurn; Desiree R. Henriquez; Daniel Diamond; Lisa Park; Jason D. Horowitz; James D. Auran; David S. Friedman; C. Gustavo De Moraes; George Cioffi; Jeffrey M Liebmann; Lisa A. Hark

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 126. doi:

Association between Open-Angle Glaucoma Subtypes and Dementia Open Access

Fei Yu; Nikolaos Topouzis; Ken Kitayama; Victoria L Tseng; Fotis Topouzis; Anne L Coleman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 127. doi:

Associations Between Dementia Risks and Chronic Exposures to Different Glaucoma Medication Types Open Access

Oliver Davidson; Michael Lee; Laura Gibbons; Eric Duerr; Jason Kam; Michael Brush; Aaron Y Lee; Paul Crane; Cecilia S Lee

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 128. doi:

Effects of Sahaj Samadhi Meditation on Health-related Quality of Life of Glaucoma Patients: A Pilot Feasibility Study Open Access

Monali S. S. Malvankar-Mehta; Brian Yu; Hyunsoo Jang; Cindy Hutnik

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 129. doi:

Racial and Sociodemographic Disparities in Gonioscopy During Initial Glaucoma Evaluations in the United States Open Access

Jun Hui Lee; Kristy Yoo; Carina Sanvicente; Benjamin Xu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 130. doi:

Treatment Patterns for the Spectrum of Primary Angle Closure Disease by Race and Ethnicity in the California Medicare Population Open Access

Victoria L Tseng; Ken Kitayama; Fei Yu; Anne L Coleman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 132. doi:

Anterior Chamber Depth and Angle and Associations in a Pediatric and Adult Population in Russia Open Access

Mukharram Bikbov; Gyulli Kazakbaeva; Songhomitra Panda-Jonas; Ellina Iakupova; Jost B. Jonas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 133. doi:

Prevalence ratio of primary angle-closure glaucoma and primary open-angle glaucoma in Asian population: a meta-analysis and multiple meta-regression Open Access

Young Kook Kim

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 134. doi:

Meta-analysis of incidence of closed angle glaucoma induced by mydriasis and factors associated Open Access

Christopher Anderson Clark; Dean A VanNasdale

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 135. doi:

Mortality in Neovascular Glaucoma Open Access

Kirstyn Taylor; Jose Cijin; Avital Lily Okrent Smolar; Sachin Kedar; Vikas Gulati; Deepta Abhay Ghate

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 136. doi:

Risk Factors for Retinal Vein Occlusion in California Medicare Beneficiaries with Primary Open Angle Glaucoma Open Access

Ali Jaafar Haidar; Victoria L Tseng; Fei Yu; Ken Kitayama; Anne L Coleman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 137. doi:

An Eleven-Case Series of Glaucoma Secondary to COVID-19 Open Access

Eric Moran; Ashkhan Hojati; Ben Lee; Joshua Brozek

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 138. doi:

The Development of an Ophthalmology Data Center: A Pilot Study Open Access

Addison Ione Brearton; Andrew Wronka; Rajan Chandras; Daniel Carbone; Vip Patel; Lama A. Al-Aswad

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 139. doi:

Increased level of CGRP neuropeptide potentially correlates with ex-vivo reactivation of HSV-1 from the latent trigeminal ganglia Open Access

Anish Chakraborty; Mashidur Rana; Pratima Suvas; Mizumi Setia; Susmit Suvas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 140. doi:

Cytokeratin 6a regulates secretory autophagy to control corneal inflammation Open Access

Anand Bhushan; Jonathan Chan; Yan Sun; Connie Tam

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 141. doi:

Comparison of blocking HSV-1 gK interaction with signal peptide peptidase (SPP) in the eye versus trigeminal ganglia on virus replication, eye disease and latency-reactivation in HSV-1 oc... Open Access

Shaohui Wang; Homayon Ghiasi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 142. doi:

Differential effects of E. coli versus S. typhimurium derived lipopolysaccharides on development of uveitis in the rabbit Open Access

Marianna Bacellar-Galdino; Nathaniel E Pappenhagen; Simon Kaja

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 143. doi:

Aetiology and Management of Uveitis in a Viral Haemorrhagic Fever Zone (EMERGE) Study Open Access

Shiama Balendra; Lloyd Harrison-Williams; Jalikatu Mustapha; Zikan Koroma; Alicious Kamara; Bangi Saradugu; Osman Conteh; Santigie Kamara; Huachun Wang; Tolulope Fashina; Jessica Shantha; Steven Yeh; Alasdair Kennedy

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 144. doi:

In Vivo depletion of the Herpes Simplex Virus 1 Latency Associated Transcript intron using AAV-ribozymes inhibits the establishment of neuronal latency. Open Access

Mason Shipley; Pankaj Singh; David Clair Bloom; Donna M Neumann

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 145. doi:

Severe Oculocutaneous Manifestations of Monkeypox Infection in the Immunocompromised and Management Considerations Open Access

Alexi Geevarghese; Elena Solli; Steven Carrubba; Samyuktha Guttha; Jeffrey Sims; Laurence Sperber; Ann Ostrovsky

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 146. doi:

Playing hide and seek: Role of immune cells in protecting HSV-1 during latency Open Access

Homayon Ghiasi; Shaohui Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 147. doi:

Novel Characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas Open Access

Pratima Suvas; Mizumi Setia; Mashidur Rana; Anish Chakraborty; Susmit Suvas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 148. doi:

The role of CD80 on enhancing HSV-1 pathogenicity in ocularly infected mice. Open Access

Ujjaldeep Jaggi; Harry Matundan; Homayon Ghiasi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 149. doi:

ZIKA VIRUS-INDUCED AUTOPHAGY PROMOTES VIRAL REPLICATION IN THE OCULAR TISSUE AND INHIBITION OF AUTOPHAGY RESTRICTS ITS TRANSMISSION Open Access

Faraz Ahmad; Pawan Kumar Singh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 150. doi:

HSV-1 neuron-to-eye transport is controlled by an interaction between an enhancer and anterograde transport genes Open Access

Ziyun Ye; Mason Shipley; Donna M Neumann

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 151. doi:

Mycobacterium tuberculosis dormancy in retinal pigment epithelium Open Access

Joshua Nhat-Nam Dang; Jae Jin Lee; Juhyeon Lim; Rachel Liu; Niranjana Kesavamoorthy; Hossein Ameri; Hyungjin Eoh; Narsing Rao

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 152. doi:

A flow cytometry-based method to quantify and functionally evaluate immune cell profiles in the epithelium versus stroma of HSV-1 infected cornea. Open Access

Mizumi Setia; Pratima Suvas; Mashidur Rana; Anish Chakraborty; Susmit Suvas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 153. doi:

Role of sulfatase in adhesion and internalization of Staphylococcus aureus by human corneal epithelial cells Open Access

Tomohiko Saito; Takashi Suzuki; Yuichi Hori

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 154. doi:

Herpes simplex virus type 1 (HSV1) progressive outer retinal necrosis in mice with MAIDS results in subclinical herpes simplex encephalitis Open Access

Alexander Leach; Romina Ghotbi; Jay Oh; Richard D Dix

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 155. doi:

Transcriptional Immunological Adaptation of Human Retinal Pigment Epithelial Cells to Infection with Klebsiella pneumoniae in Diabetic Ocular Environment Open Access

Yi-Hsing Chen; yih-shiou Hwang; Chia-Rui shen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 156. doi:

Comparative Proteome Profiling of Extracellular Vesicles in Murine models of Bacterial and Fungal Endophthalmitis Open Access

Joveeta Joseph Ruben; Dhanwini Rudraprasad; JAISHREE GANDHI

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 157. doi:

Staphylococcus aureus alpha-toxin contributes to increased incidence in a murine model of experimental endogenous bacterial endophthalmitis Open Access

Phillip S Coburn; Austin LaGrow; Aaron Parrott; Frederick Christian Miller; Michelle C Callegan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 158. doi:

Ebselen ameliorates Herpes Stromal Keratitis (HSK) opacity besides reducing Herpes Simplex Virus-1(HSV-1) load Open Access

Mashidur Rana; Mizumi Setia; Pratima Suvas; Anish Chakraborty; Susmit Suvas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 159. doi:

Role of oxidative stress in pathogenesis of Aspergillus flavus keratitis Open Access

Sanhita Roy; Sreyanki Chandra; Srijita Kundu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 160. doi:

Extracellular vesicle-associated Complement cascade 8-alpha and Calpain-2 in human vitreous as biomarkers for bacterial endophthalmitis Open Access

Dhanwini Rudraprasad; Nirmal Jayabalan; Velmurugan K; Joveeta Joseph Ruben

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 161. doi:

Acanthamoeba aggregate and encyst on silicone hydrogel contact lenses Open Access

Monica Crary; Allison Campolo; Reed Pifer; Rhonda Walters; Chris Rice; Megan Thomas; Elise Miller; Valerie Harris; Jamie King; S. Paul Shannon; Brian Patterson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 162. doi:

Keratin 6a dampens Toll-like receptor-triggered proinflammatory response in corneal epithelial cells by inhibiting ELKS/IKKε-dependent activation of NF-κB Open Access

Jonathan Chan; Yan Sun; Anand Bhushan; Andy Lui; Connie Tam

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 163. doi:

SINGLE CELL ATLAS OF THE ADULT LACRIMAL GLAND UNCOVERS CELLULAR COMPLEXITY, PROGENITOR-LIKE CELLS AND SEXUAL DIMORPHISM Open Access

Vanessa DELCROIX; Olivier Mauduit; Hyun Soo Lee; Anastasiia Ivanova; Takeshi Umazume; Sarah Knox; Cintia S. De Paiva; Darlene A Dartt; Helen P Makarenkova

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 164. doi:

Establishment and characterization of a human lacrimal gland epithelial cell line Open Access

Sophie Gleixner; Friedrich P Paulsen; Philipp Arnold

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 165. doi:

Sdr16c5 and Sdr16c6 genes control a bifurcation point between meibogenesis and sebogenesis in Meibomian glands of mice by suppressing a dormant biosynthetic pathway Open Access

Igor A Butovich; Amber Wilkerson; Kelly R. Goggans; Natalia Kedishvili; Seher Yuksel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 166. doi:

Thermosensitive TRP channels in the human meibomian gland Open Access

Melina Keller; Friedrich P Paulsen; Ingrid Zahn; Stefan Mergler; Aruna Li; Fabian Garreis

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 167. doi:

Relationship between Meibomian gland morphology and the meibum lipidome Open Access

Fatima Iqbal; Jacqueline Tan; Eric B Papas; Simin Masoudi; Fiona Stapleton

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 168. doi:

Prolactin Inducible Protein in human tears and human ocular cell lines – an overview Open Access

Katharina Jüngert; Friedrich P Paulsen; Jutta Horwath-Winter; Christina Jacobi; Sophie Gleixner; Fabian Garreis

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 169. doi:

Single-Cell Analysis Explains Differences Between Lacrimal and Submandibular Gland Structure and Function Open Access

Helen P Makarenkova; Olivier Mauduit; Vanessa DELCROIX

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 170. doi:

Retinoic acid receptor X alpha mutant strain develops meibomian gland disease with aging Open Access

Ebru Yaman; Igor A Butovich; Jahan Alam; Amber Wilkerson; Ghasem Yasdanpanah; Stephen C Pflugfelder

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 171. doi:

Nonclinical assessment of repeated dosing of AZR-MD-001 to the lower eyelid (Selenium Sulphide, SeS₂, sterile ophthalmic ointment): A novel therapy being developed for meibomian gland dys... Open Access

Limor Miara; Glenwood G Gum; Luba Litinetsky; Kathleen Krenzer; Linda Manza; Charles Bosworth; Yair Alster; Hila Epstin-Barash

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 172. doi:

Developing a rat model of UVB-induced ocular surface and eyelid injuries mimicking ocular rosacea Open Access

Linxin Zhu; Daniela Rodrigues-Braz; Emmanuelle Gelize; Iris Clavier; Jean-Louis Bourges; Francine F Behar-Cohen; Min Zhao

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 173. doi:

Influence of melanocortin receptors in human meibomian glands Open Access

Ingrid Zahn; Fabian Garreis; Friedrich P Paulsen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 174. doi:

Transitory alkali exposure on meibomian gland orifices induces meibomian gland dysfunction Open Access

JingHua Bu; yang wu; Zuguo Liu; Wei Li

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 175. doi:

Regulatory T cells are essential for controlling autoimmune eye and lacrimal gland pathogenic cells Open Access

Kaitlin Scholand; Jeremias Gaston Galletti; Gowthaman Govindarajan; Cintia S. De Paiva

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 176. doi:

Novel extracellular matrix based hydrogel for lacrimal gland tissue engineering Open Access

Katharina Elisabeth Wiebe-Ben Zakour; Sema Kaya; Amina Cheikh-Rouhou; Michael Hacker; Gerd Geerling; Joana Witt

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 177. doi:

Laserkanthoplasty – Assessment of laser parameters to improve lid tension Open Access

Alexandra Schilcher; Amar Avdakovic; Alessa Hutfilz; Katharina Elisabeth Wiebe-Ben Zakour; Erich Knop; Dirk Theisen- Kunde; Christoph Holtmann; Joana Witt; Gerd Geerling

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 178. doi:

Generation of a novel rabbit model for meibomian gland dysfunction Open Access

Pragnya Rao Donthineni; Deeksha Prasad; Mohammed Salman; Saumya Jakati; Kiran bokara; Sayan Basu; Vivek Singh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 179. doi:

Notch signaling is required for postnatal development of the lacrimal gland Open Access

Yihua Wu; Xin Zhang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 180. doi:

In vitro evaluation of efficacy of 5-Fluorouracil (5-FU) on survival of Ocular Demodex isolated from chronic blephritis Open Access

Kaivan Patel; Anny Mansim Cheng; Raphael Banoub; Joby Tsai; Kakarla V Chalam

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 181. doi:

Novel inflammatory biomarkers in tear fluids of patients with type 2 diabetes and dry eye disease Open Access

Suzanne Hagan; Mungunshur Byambajav; Andrew Collier; Xinhua Shu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 182. doi:

Using the DxH 500 hematology analyzer to differentiate leukocytes in human tears Open Access

Justina Raouf Assaad; Pradipta Bhattacharya; Maria Walker

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 183. doi:

Contact Lenses as Non-Invasive Ocular Biomarker Vehicles for Tear Fluid Collection, Storage, and Analyses Open Access

Nikolay Boychev; Vincent Yeung; Menglu Yang; Amy E Ross; Liangju Kuang; Lin Chen; Joseph B Ciolino

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 184. doi:

Intraday variation in the tear fluid proteome Open Access

Garrett Nicholas Jones; Tae Jin Lee; Joshua Glass; Wenbo Zhi; Shruti Sharma; Ashok Sharma

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 185. doi:

Tear Breakup (TBU) Analysis with Fluorescence (FL) and Thermal (TH) imaging Open Access

Richard J Braun; Tobin Driscoll; Carolyn Begley; Ping Situ; Anna Tichenor; Rayanne Luke

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 186. doi:

Intrinsic disorder and the human tear film proteome Open Access

Mak Benjamin Djulbegovic; David J Taylor; Michael Antonietti; Matthew Cordova; Guy Dayhoff; Vladimir Uversky; Anat Galor; Carol L Karp

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 187. doi:

Comparative Biophysical Study of Meibomian Lipids of Wild Type and Soat1-Knockout Mice: Implications to Dry Eye Open Access

Yi Zuo; Xiaojie Xu; Amber Wilkerson; Igor A Butovich

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 188. doi:

Biophysical characteristics of the tear film in school-aged children Open Access

Poonam Mudgil; Ngozi Charity Chidi-Egboka; Isabelle Jalbert; John Whitehall; Blanka Golebiowski

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 189. doi:

Evaluating the Efficacy of Various Artificial Tear Formulations Open Access

Emily Rose White; Nicholas Fazio; Konstantinos Tourmouzis; Jennifer Yang; Sarah Weissbart; Timothy Chou; Mary Tam; Basil Rigas; Robert A Honkanen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 190. doi:

Tear Film Thickness (TFT) is the Most Sensitive Measure to Capture Differences in the Critical Quality Attributes of a Formulation Using Anterior Segment Optical Coherence Tomography (AS-... Open Access

Vatsala Naageshwaran; Glenwood G Gum; Sandeep Kumar; Linda Manza; Matthew Lyulkin; Nicholas Cook; Xiaoming Xu; Deval Patel; Haiou Qu; Ross Walenga; Mingliang Tang; Andrew Babiskin; Mohammad Abul Kaisar; Darby Kozak

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 191. doi:

Effect of contact lens wear on tear film dynamics as measured by a novel Tear Film Imager (TFI) Open Access

Kelly Acuna; Simran Mangwani; Anat Galor

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 192. doi:

A Device to Meassure Electrical Spectral Impedance (ESI) in tne cornea: an objective tool to discriminate Dry Eye Disease, Penfigoid and Sjogren Syndrome. Open Access

Mario J Saravia; Fernanda Forgues; Pablo Bazterrechea; Luis Zeman; Fabian Bonetto

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 193. doi:

The effects of artificial tears on the tear film using a novel, high-resolution tear film imager: a pilot study Open Access

Isaac M Tessone; Gal Antman; Hernan Rios; Sofia Ahsanuddin; Luis MuncharazDuran; Alice Chandra Verticchio Vercellin; Brent A Siesky; Rebecca Kellner; Paul A Sidoti; Masako Chen; Lukas Ritzer; Emanuel Mordechaev; Ethan Moy; Toco Y. P. Chui; Richard B Rosen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 194. doi:

Unbiased Screening of Meibomian Lipids for Affinity to Natural C-Terminal Lacritin Proteoforms Necessary for the Prevention of Tear Film Collapse. Open Access

Jeff Romano; Georgi Georgiev; Jianzhong Chen; Marc Odrich; Gordon W Laurie

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 195. doi:

The role of epithelial membrane-associated mucin 4 (Muc4) in ocular surface health and corneal wound healing Open Access

Sara Adelman; Melinda Quan; Erin Hisey; Christopher J Murphy; Sara M Thomasy; Brian Leonard

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 196. doi:

Tear protein biomarkers for pain after refractive surgery: candidate discovery Open Access

BROOKE HARKNESS; Deborah Hegarty; Larry L David; Siting Chen; Jodi Lapidus; Julie Saugstad; Hannah Behrens; Winston Chamberlain; Richard Stutzman; Maricarmen Perez-Blanco; Jason Betz; Anat Galor; Sue Aicher

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 197. doi:

In vivo evidence that skin lipids may be a cause of dry eye in humans Open Access

Jim Kokkinakis

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 198. doi:

A Case Series: Rituximab in the treatment of Ocular Surface Disease Open Access

Anisha Sekaran; Ore-Oluwa Erikitola; Elisabeth MacDonald; Kanna Ramaesh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 199. doi:

Effect of probiotics on aging-dependent gut dysbiosis in autoimmune dry eye mouse model Open Access

Seonghwan Kim; Jin Suk Ryu; Nakwon Hwang; Jung-Eun Kim; Eun Seok Choi; So Yeon In; Seok-Jin Kim; Junho Chung; Mee Kum Kim

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 200. doi:

Artificial intelligence for the diagnosis of ocular surface squamous neoplasia using in vivo confocal microscopy Open Access

Kincso Boglarka Kozma; Zoltan Richard Janki; Vilmos Bilicki; Adrienne Csutak; Eszter Szalai

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 201. doi:

Microbime and Ocular Surface Disease: Exploring the Microbiota Niche to Characterize New Eye Community State Types. Open Access

Davide Borroni; Andreu Paytuví-Gallart; Walter Sanseverino; Giulio Basile; Vito Romano; Cosimo Mazzotta; Rahul Rachwani; Facundo Urbinati; Cecilia Garcia-Lopez; Miguel Rechichi; Carlos Rocha de Lossada

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 202. doi:

Association of Clinical Signs with the Ocular Surface Disease Index: Preliminary Results from the Multicenter Neurosensory Abnormalities in ocular SurfAce Disease (NASA) study Open Access

Milton M Hom; Stephanie Cox; Loretta Szczotka; Nancy S. Gee; Pedram Hamrah

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 203. doi:

Composition and comparison of core conjunctival sac microbiome in Hong Kong Children by age, sex and ethnicities Open Access

Xiangtian Ling; Xiu Juan Zhang; Christine Bui; Clement C. Tham; Calvin C P Pang; Li Jia Chen; Jason C. Yam

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 204. doi:

Antifibrotic activity of Siempreviva sap for potential pterygium treatment Open Access

Katiana Flores Nucamendi; Mairobi Persinal-Medina; David Eguenio Rodriguez; Alfredo Del Castillo; Karla Carrasco; Daniel Dares; Alberto Castilo; Judith Zavala; Jorge E Valdez

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 206. doi:

Exosome Isolation from Human Tears Open Access

Bohan Xing; Remington M Bliss; Leila Jamal; Burke Lieppman; Brian S McKay; Xuemin Zhang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 207. doi:

Effectiveness of topical antiseptics in reducing conjunctival bacterial microbiota: randomized clinical trial. Open Access

Vito Romano; Francesca Gatti; Davide Borroni; Giulio Basile; Mariantonia Ferrara; Francesco Semeraro

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 208. doi:

The new once-daily multidose preservative-free 0.6% bilastine eye drop formulation containing sodium hyaluronate preserves ocular surface integrity and tear film homeostasis in a comparat... Open Access

Tatiana M. Suarez-Cortes; Eider Arana; Ana Gonzalo; Arturo Zazpe; Ines Torrens; Noelia Andollo; Javier Soria; Gonzalo Hernández

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 209. doi:

Inhibition of neutrophil activation by pooled human immune globulins Open Access

Vidhya R Rao; Sana Iqbal; Anita K. Ghosh; Christine Mun; Sandeep Jain; Marianna Bacellar-Galdino; Simon Kaja

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 210. doi:

Is eye makeup associated with poor ocular surface parameters in women with dry eyes? Open Access

Ayyad Zartasht Khan; Fredrik Fineide; Morten Schjerven Magno; Hugo Hammer; Xiangjun Chen; Andrea Storås; Pål Halvorsen; Tor Paaske Utheim

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 211. doi:

Autonomous artificial intelligence exams are associated with higher adherence to diabetic retinopathy testing in an integrated healthcare system Open Access

Jane Huang; Jiangxia Wang; Roomasa Channa; Risa Wolf; Michael David Abramoff; T. Y. Alvin Liu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 212. doi:

Comparison of Open Neural Network Exchange (ONNX) and TensorFlow based inferences for the B-scan of interest algorithm Open Access

Hugang Ren; Stefan Duca; Neil D'Souza

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 213. doi:

AAV dose-dependent transduction efficiency in RGCs and functional efficacy of CoChR3M-mediated vision restoration Open Access

QI LU; Anna Wright; Gary W Abrams; Zhuo-Hua Pan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 214. doi:

Cascaded Defending and Detecting of Adversarial Attacks Against Deep Learning System in Ophthalmic Imaging Open Access

Wei Yan Ng; Yanyu Xu; Xinxing Xu; Daniel SW Ting

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 215. doi:

Augmented reality for retinal laser therapy Open Access

Sangjun (Sarah) Eom; Miroslav Pajic; Maria Gorlatova; Majda Hadziahmetovic

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 216. doi:

Role of 6-tioguanine in a mouse model of diabetic retinopathy Open Access

Marina Russo; Carlo Gesualdo; Maria Consiglia Trotta; Caterina Claudia Lepre; Filomena De Nigris; Claudio Bucolo; Michele D'Amico; Francesca Simonelli; Settimio Rossi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 217. doi:

Automated Deep Learning-based Disease Feature Quantification on Color Fundus Photographs for Prediction of Late-stage Age-related Macular Degeneration Open Access

Haras Mhmud; Eric F. Thee; Bart Liefers; Corina Brussee; Amal Hamimida; Irene van Zeijl; Annemiek Krijnen; Daniel Luttikhuizen; Caroline C W Klaver

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 218. doi:

Cluster stability and its relationship to blood pressure, intraocular pressure and hemodynamic variables in the human retina Open Access

Daphne Zou; James Keller; Alon Harris; Giovanna Guidoboni

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 220. doi:

Investigation of surgical performance metrics of vitreoretinal surgeons by analyzing their instrument handling via neural networks Open Access

Rogerio Nespolo; Daniel Wang; Alexis Warren; Darvin Yi; Hesham Gabr; Yannek Leiderman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 221. doi:

Impact of training data diversity on the generality of automated diabetic retinopathy screening in fundus photographs Open Access

Sarah Matta; Mathieu Lamard; Clément Lecat; Laurent Borderie; Pascale Massin; Béatrice Cochener; Alexandre Le Guilcher; Gwenole Quellec

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 222. doi:

Automated machine learning to predict anatomical outcomes in pneumatic retinopexy Open Access

Arina Nisanova; Arefeh Yavary; Jordan Deaner; Ferhina S. Ali; Priyanka Gogte; Richard Kaplan; Kevin C Chen; Eric Nudleman; Dilraj Grewal; Meenakashi Gupta; Jeremy Wolfe; Michael Klufas; Glenn Yiu; Iman Soltani-Bozchalooi; Parisa Emami-Naeini

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 223. doi:

Data Labeling for Artificial Intelligence (AI) Algorithms for Measurement of Geographic Atrophy Open Access

Rohit Balaji; Robert Slater; Jacob Bogost; Gelique Ayala; Jeong W Pak; Rick Voland; Roomasa Channa; Barbara A Blodi; Donald S Fong; Amitha Domalpally

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 224. doi:

A novel deep learning-based tool to detect macular atrophy in patients with AMD Open Access

Wei Wei; Radhika Pooja Patel; Francesca Cordeiro

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 225. doi:

Training Size Effect on Deep Learning Models for Geographic Atrophy Open Access

Robert Slater; Mark Banghart; Roomasa Channa; Barbara A Blodi; Donald S Fong; Amitha Domalpally

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 226. doi:

Developing a 10 layer retinal segmentation with applications to MacTel Open Access

Aayush Verma; Simone Tzaridis; Yue Wu; Martin Friedlander; Aaron Y Lee

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 227. doi:

Identifying Causes of Ungradable Fundus Photos in an Artificial Intelligence Assisted Screening Program for Diabetic Retinopathy Open Access

Tyler Najac; Christina Nelson; Shyla McMurtry; Amanda Luong; Jesse Cheung; Lorrie Cheng; Julia Grachevskaya; Oleg Shum; Sherona Tillmon; Jeffrey D Henderer; Yi Zhang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 228. doi:

Internal and external validation of a deep learning model for estimating non-perfusion areas from ultra-widefield fundus images Open Access

Hidenori Takahashi; Satoru Inoda; Yoichiro Hisadome; Yusuke Kondo; Hironobu Tampo; Takuya Takayama; Kosuke Nagaoka; Shinichi Sakamoto; Yusaku Katada; Toshihide Kurihara; Hidetoshi Kawashima; Yasuo Yanagi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 229. doi:

Automated classification of ophthalmic image quality Open Access

Richard E. Daws; James Owler; Jonathan Young; Jake Kenworthy; Natalie Pankova; M Francesca Cordeiro

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 230. doi:

Characterization of Baseline “EZ At-Risk” Burden Using Deep Learning Feature Extraction in the GATHER1 Phase 2/3 Clinical Trial. Open Access

Sari Yordi; Gagan Kalra; Hasan Cetin; Jon Whitney; Conor Anthony McConville; Yavuz Cakir; Victoria Eileen Whitmore; Jamie Reese; Julie Clark; Liansheng Zhu; Sunil K Srivastava; Justis P Ehlers

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 231. doi:

Exploring potential for automatic change alert for diagnosis of optic nerve change head changes in a diabetic population Open Access

Louise O'Toole; Kate Coleman; Hector Franco O Penya; Jason Coleman; David J Keegan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 232. doi:

Retinal age gap - a novel biomarker of cardiovascular disease Open Access

Zhuoting Zhu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 233. doi:

Cross-modality optical coherence tomography image enhancement using deep learning Open Access

Valentina Bellemo; Ankit Kumar; Damon Wong; Jacqueline Chua; Xinxing Xu; Xinyu Liu; Liu Yong; Leopold Schmetterer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 235. doi:

Artficial intelligence based referral and progression of diabetic kidney disease using retinal fundus images Open Access

Raghu Prasad; Anvesh Vankayala; Ankit Chavhan; MANSI GUPTA; Ganesh Babu TC; Shankar Prasad Nagaraju; Sulatha V Bhandary

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 236. doi:

Periodontal disease and outer retinal morphology: A cross-sectional analysis of the UK Biobank cohort Open Access

Josef Christian Huemer; Siegfried Wagner; Praveen J Patel; Mario Cortina Borja; Robbert Struyven; David Romero-Bascones; Dominic Williamson; Anthony P Khawaja; Axel Petzold; Konstantinos Balaskas; Iain Chapple; Thomas Dietrich; Jugnoo Rahi; Alastair K Denniston; Pearse Keane

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 237. doi:

Contrastive Learning Driven Self-Supervised Framework for Segmentation of Biomarker of Diabetic Macular Edema Open Access

Hina Raja; Muhammad Usman Akram; Siamak Yousefi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 238. doi:

Multicenter study to validate an artificial intelligence algorithm for the screening of diabetic retinopathy: the CARDS study Open Access

Juan Donate-Lopez; Gabriela Susanna González-Bueno; Jose Natan Rodriguez-Martin; Joseph Blair; Sandro De Zanet; José Julio Rodrigo-Bello; Carlos Bermudez-Perez; Rodrigo Abreu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 239. doi:

Predicting major adverse cardiovascular events with colour fundus photograph in the AlzEye Study Open Access

Yukun Zhou; Siegfried Wagner; Mark Chia; Dominic Williamson; Robbert Struyven; Timing Liu; Axel Petzold; Jugnoo Rahi; Mario Cortina Borja; Alastair K Denniston; Daniel Alexander; Pearse Keane

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 240. doi:

A pilot study of machine learning models for prediction of treatment response in patients with diabetic macular edema in a phase II clinical trial Open Access

Zhuoyu Wen; Yusuke Kikuchi; Oluwatobi Idowu; Jian Dai; Qi Yang; Carlos Quezada-Ruiz

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 241. doi:

Transfer learning with VGG16 deep convolutional neural network model effectively differentiates between subtypes of bright and dark lesions Open Access

Anna Kay; Mickey Nguyen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 242. doi:

Autonomous artificial intelligence (AI) increases health equity for patients who are more at risk for poor visual outcomes due to diabetic eye disease (DED) Open Access

Ariel Leong; Jiangxia Wang; Risa Wolf; Roomasa Channa; Michael David Abramoff; Harold Lehmann; T. Y. Alvin Liu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 243. doi:

Mitochondrial functional impairment in skin fibroblasts of patients with ARL3-related retinitis pigmentosa Open Access

Shun Yao; Bo Lei

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 244. doi:

Efficacy of Automated Point-of-Care Screening for Diabetic Retinopathy in Southern Malawi Open Access

Philip Burgess; Shaffi Mdala; Thoko Zungu; Joe Aslan; Gertrude Banda; Shane D'Souza; Joep van Oosterhout; Peter Soliz; Petros Kayange

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 245. doi:

Time-aware deep models for predicting diabetic retinopathy progression Open Access

Rachid zeghlache; Pierre-henri Conze; Mostafa EL HABIB DAHO; YIHAO LI; Ikram Brahim; Hugo Le Boité; Pascale Massin; Ramin Tadayoni; Béatrice Cochener; Gwenole Quellec; Mathieu Lamard

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 246. doi:

Artificial intelligence to differentiate smokers and non-smokers using fluorescence lifetime imaging ophthalmoscopy Open Access

Yoko Miura; Christian Thiemann; Svenja Rebecca Sonntag; Marie Kreikenbohm; Giulia Böhmerle; Jessica Stagge; Thomas Martinetz; Salvatore Grisanti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 248. doi:

Associations between COPD and retinal vessel density, fractal dimension, and tortuosity density Open Access

Olivia Norah Murray; Timing Liu; Yukun Zhou; Dominic Williamson; Robbert Struyven; Siegfried Wagner; Konstantinos Balaskas; Mario Cortina Borja; Axel Petzold; Jugnoo Rahi; Alastair K Denniston; Pearse Keane

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 249. doi:

Predictive value of an artificial intelligence algorithm to identify images with characteristics of exudative lesions. Open Access

Claudia Acosta; Carolina Sardi; Juan Gonzalo Sanchez; Laura Velásquez; Maria Adelaida Piedrahita; Julian Alexander Martinez; José David Gómez

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 250. doi:

Performance of two ultra-widefield retinal imaging systems for the automatic diagnosis of diabetic retinopathy Open Access

Mostafa EL HABIB DAHO; Rachid zeghlache; YIHAO LI; Hugo Le Boité; Sophie Bonnin; Stephanie Magazzeni; Laurent Borderie; Bruno Lay; Ramin Tadayoni; Béatrice Cochener; Pierre-henri Conze; Mathieu Lamard; Gwenole Quellec

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 251. doi:

Real world outcomes from artificial intelligence to detect diabetic retinopathy in the primary care setting: 12 month experience Open Access

Austen N Knapp; Eliot Dow; Karen Chen; Nergis C Khan; Diana V Do; Vinit Mahajan; Prithvi Mruthyunjaya; Theodore Leng; David Myung

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 252. doi:

An Algorithm for Detecting Leaky Retinal Microaneurysms Open Access

Colyn Munn; Lyna Kamintsky; Yonatan Serlin; Aaron Winter; Alan Cruess; Alon Friedman; Jaime Levy; Oren Tomkins-Netzer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 253. doi:

Prognosis of visual acuity and retinal atrophy in patients with myopic choroidal neovascular membrane treated with anti-vascular endothelial growth factor Open Access

LINA CHEN; Dilnaz Saini; Mano Chandrakumar; Michael Balas; Rajeev Hemant Muni; Carmen Balian; Tom Wright; Vera Stiuso; Peng Yan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 254. doi:

Ethnic Diversity of Retinal Images Used to Train Artificial Intelligence Models Improves Diagnostic Accuracy to Detect Diabetic Retinopathy Open Access

Cris Martin P. Jacoba; Duy Doan; Dean Zhang; Ward Fickweiler; Catherine Jamison; Ahmed Souka; Monsef Kharboush; Frank Albert; Kaye Locaylocay; Moises Dumapig; Recival Salongcay; Mohamed Ashraf; Jennifer K Sun; Tunde Peto; Lloyd P Aiello; Paolo S Silva

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 255. doi:

Cynomolgus monkey’s retina volume reference database based on hybrid deep learning optical coherence tomography segmentation Open Access

Nora Denk; Pascal W. Hasler; Hendrik Scholl; Maloca Peter

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 256. doi:

Quantifying Uncertainty of Deep Learning Models for the Segmentation of Geographic Atrophy Open Access

Theodore Spaide; Julia Owen; Luis De Sisternes; Warren Lewis; Niranchana Manivannan; Varsha Pramil; Harris Asad Sheikh; Nadia K Waheed; Cecilia S. Lee; Aaron Y Lee

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 257. doi:

An Automated Tool for Quantitative Assessment of Retinal Vasculopathy Open Access

Oren Tomkins-Netzer; Colyn Munn; Lyna Kamintsky; Amir Abbasnejad; Yonatan Serlin; Aaron Winter; Alan Cruess; Alon Friedman; Jaime Levy

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 258. doi:

Explainable diagnosis based on retinal fundus images using deep learning Open Access

Ipek Oruc; Parsa Delavari; Gulcenur Ozturan; Ozgur Yilmaz

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 259. doi:

Deep Learning for prediction of rhegmatogenous retinal detachment relapse using preoperative and postoperative wide field imaging Open Access

Fiammetta Catania; Thibaut Chapron; William Beaumont; Ismael Chehaibou; Florence Metge; Youssef Abdelmassih; Georges Caputo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 260. doi:

Automated identification of geographic atrophy eyes with and without subfoveal involvement using machine learning and real-world ophthalmic images in the IRIS Registry Open Access

Zhongdi Chu; Theodore Leng; Durga S Borkar; Carlos Candano; Kim Le; Aishwarya Ramakrishnan; Ketki Khapare; Michael Mbagwu; Aracelis Torres

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 261. doi:

Deep-learning enabled multi-modal fusion models for dementia screening using colour fundus photographs Open Access

Dominic Williamson; Robbert Struyven; Siegfried Wagner; David Romero-Bascones; Yukun Zhou; Mateo Gende Lozano; Timing Liu; Mario Cortina Borja; Jugnoo Rahi; Axel Petzold; Yue Wu; Cecilia S. Lee; Aaron Y Lee; Alastair K Denniston; Daniel Alexander; Pearse Keane

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 262. doi:

A domain adaptation method for deep learning based automatic diabetic retinopathy grading Open Access

Bingyuan Liu; Hadi Chakor; Riadh Kobbi; Balamurali Murugesan; Waziha Kabir; Jihed Chelbi; Marc-André Racine; Jose Dolz; Ismail Ben Ayed

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 263. doi:

Repeatability of photopic negative response parameters in normal subjects using Diopsys®NOVA™ Open Access

Isabel Sendino; Amir Akhavanrezayar; Negin Yavari; Andrea Perez-Alvarez; Irmak Karaca; SungWho Park; Hassan khojasteh; Hashem Ghoraba; Chi Mong Christopher Or; Albert Bromeo; Cigdem Yasar; Ngoc Than; Vahid Bajozoo; Gunay Uludag; Diana V Do; Quan Dong Nguyen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 264. doi:

Prediction of Geographic Atrophy Enlargement using Various Deep Learning Approaches Open Access

Amitha Domalpally; Robert Slater; Mark Banghart; Roomasa Channa; Donald S Fong; Barbara A Blodi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 265. doi:

Machine learning for Classifying Proliferative Diabetic Retinopathy in Latino and African American Cohorts Open Access

Eun Taek Yoon; Ayelet Goldstein; Kun Ding; Ariela Gordon-Shaag; Jonathan Levine

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 266. doi:

Evaluation of Landmark Localization Models for Fundus Imaging Conditions Open Access

Rohan Kalahasty; Lakshmi Sritan Motati; Saber Kazeminasab Hashemabad; Min Shi; Yan Luo; Yu Tian; Nazlee Zebardast; Mengyu Wang; Tobias Elze; Mohammad Eslami

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 267. doi:

External Validation of Autonomous Retinopathy of Prematurity Screening in the SUNDROP Program Open Access

Tom Murickan; Aaron S Coyner; Susan Ostmo; Darius M Moshfeghi; Robison Vernon Paul Chan; Jayashree Kalpathy-Cramer; Michael F Chiang; J. Peter Campbell

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 268. doi:

Artificial intelligence evaluation of diabetic retinopathy using smartphone retinal fundus photography Open Access

Julien Levy; Mickey Nguyen; Angela Yim; Yunshu Zhou; Ehsan Vaghefi; Tyson Kim; Yannis Mantas Paulus

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 269. doi:

Prediction of imminent conversion to neovascular age-related macular degeneration using deep learning and optical coherence tomography images Open Access

T. Y. Alvin Liu; Yuxuan Liu; Craig Jones

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 271. doi:

Deep-learning-aided vascular tortuosity analysis in eyes with idiopathic epiretinal membrane Open Access

KEITA BABA

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 272. doi:

Investigating AI’s Unreasonable Effectiveness in Detecting Self-Declared Racial Identity from Retinal Vascular Maps Open Access

Riya Tyagi; J. Peter Campbell; Aaron S Coyner; Susan Ostmo; Wei-Chun Lin; Deniz Erdogmus; Robison Vernon Paul Chan; Michael F Chiang; Jayashree Kalpathy-Cramer; Praveer Singh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 273. doi:

Prediction of chronic and recurrent forms of Central Serous Chorioretinopathy based on ICGA and OCT features Open Access

Emanuele Crincoli; Alexandra Miere; Nabil Herda; Fiammetta Catania; Juan Manuel Lopez; Silvia Ferrara; Riccardo Sacconi; Giuseppe Querques; Eric Souied

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 274. doi:

OCTA Layer Information Fusion for Deep Learning Classification of Diabetic Retinopathy Open Access

Behrouz Ebrahimi; David Le; Mansour Abtahi; Albert Kofi Dadzie; Jennifer I Lim; Xincheng Yao

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 275. doi:

Deep Learning Guided Quantification of Retinal Nerve Fiber Layer in a Non-Human Primate Model of Experimental Glaucoma Open Access

Kamal Dhakal; Shima Mehrvar; Lakshmi Rajagopalan; Magali Guffroy; Corine Ghosn; Mohammed Dibas; Bhupinder Bawa

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 276. doi:

Investigating Rabbit Persistent Retinal Neovascularization (PRNV) Model Leveraging Artificial Intelligence (AI)-assisted OCT & FA Assessment Open Access

Weiwei Luo; xiao yang; Daniel Metzger; Sook Chung; Liming Yang; Nina Li; Xiaolan Shen; Asad Abu Bakar Ali

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 277. doi:

Tolerability and safety of intravitreal aflibercept 8 mg in the Phase 3 PULSAR trial of patients with neovascular age-related macular degeneration Open Access

Jean-Francois Korobelnik; Ursula Maria Schmidt-Ott; Andrea Schulze; Xin Zhang; Sergio Leal

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 278. doi:

3-D analysis of multiple OCTA acquisitions for the automatic diagnosis of diabetic retinopathy Open Access

YIHAO LI; Mostafa EL HABIB DAHO; Pierre-henri Conze; Rachid zeghlache; Hugang Ren; Capucine Lepicard; Pierre Deman; Alexandre Le Guilcher; Béatrice Cochener; Ramin Tadayoni; Mathieu Lamard; Gwenole Quellec

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 279. doi:

Early swept-source OCT-A findings after switching to faricimab in recalcitrant exAMD Open Access

Arnold Nadel; Alessandro Marchese; Avram Bar Meir; Rukhsana Mirza

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 280. doi:

Decreased macular choriocapillaris perfusion in eyes with macular reticular pseudodrusen imaged with swept-source OCT angiography Open Access

Philip J Rosenfeld; Jianqing Li; Ziyu Liu; Jie Lu; Mengxi Shen; Yuxuan Cheng; Nadia Siddiqui; Qinqin Zhang; Jeremy Liu; Gissel Herrera; Farhan E. Hiya; Giovanni Gregori; Ruikang K Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 281. doi:

Blood Vessel Segmentation on Retinal Image Scans Employing Artificial Intelligence Open Access

Akshay Jakkidi Reddy; Nathaniel Tak; James Martel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 282. doi:

Spectral-domain and swept-source OCT angiographic scans yield similar drusen measurements when processed with the same algorithm Open Access

Farhan Hiya; Jeremy Liu; Mengxi Shen; Gissel Herrera; Jianqing Li; Luis De Sisternes; Qinqin Zhang; Philip J Rosenfeld; Giovanni Gregori

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 283. doi:

A novel deep learning approach for identifying outer retinal tubulations in retinal degenerations Open Access

Amandeep Josan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 284. doi:

Quantitative arterial-venous flow index analysis in optical coherence tomography angiography of diabetic retinopathy Open Access

Mansour Abtahi; David Le; Behrouz Ebrahimi; Albert Kofi Dadzie; Jennifer I Lim; Xincheng Yao

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 285. doi:

A framework for analyzing choriocapillaris flow voids in patients with geographic atrophy based on optical coherence tomography angiography (OCTA) Open Access

Leopold Schmetterer; Ashe Lee; Bingyao Tan; Nils Schaerer; Peter Maloca; Andrea Giani; Marieh Esmaeelpour; Hendrik Scholl

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 286. doi:

Visual Correlation of OCT-Angiographic Features in Neovascular Age-Related Macular Degeneration Open Access

Kevin Elwood; Rachel E Linderman; Jeong W Pak; Rick Voland; Amitha Domalpally; Barbara A Blodi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 287. doi:

Concordance of OCT and FA-based MNV classifications in neovascular AMD and correlation with fluid volumes Open Access

Gabor Deak; Bianca S Gerendas; Georgios Mylonas; Guenther Weigert; Martin Michl; Felix Goldbach; Oliver Leingang; Irene Steiner; Ursula Schmidt-Erfurth

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 288. doi:

Is a decreased choriocapillaris perfusion implicated in the pathology of AMD? An OCTA – fundus autofluorescence study Open Access

Martin Hammer; Somar Hasan; Daniel Meller; Melih Tarhan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 289. doi:

Decreased ganglion cell complex in eyes with macular reticular pseudodrusen Open Access

Yi Zhang; Jianqing Li; Jie Lu; Mengxi Shen; Yuxuan Cheng; Qinqin Zhang; Jeremy Liu; Gissel Herrera; Farhan E. Hiya; Giovanni Gregori; Philip J Rosenfeld; Ruikang K Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 290. doi:

Longitudinal Changes in Pigment Epithelial Detachment Composition Indices (PEDCI): New Imaging Biomarkers in Wet Age-Related Macular Degeneration Open Access

Sanjana Harihar; Amrish Selvam; Stavan Shah; Sumit Singh; Vinisha Sant; Supriya Arora; Manan Patel; Joshua Ong; Sanya Yadav; Mohammed Ibrahim; José-Alain Sahel; Kiran Kumar Vupparaboina; Jay Chhablani

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 291. doi:

Utility of automated macular fluid volume measurement for detecting neovascular exudative age-related macular degeneration Open Access

Steven Bailey; Kotaro Tsuboi; Ramkailash Gujar; Yukun Guo; JIE WANG; Christina J Flaxel; David Huang; Thomas S Hwang; Yali Jia

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 292. doi:

Relationship between Delayed RMDA and the Ellipsoid and Interdigitation Zones in Age-related Macular Degeneration (AMD): ALSTAR2 baseline Open Access

Sohaib Fasih-Ahmad; Ziyuan Wang; Zubin Mishra; Charles Vatanatham; Mark E. Clark; Christine A. Curcio; Cynthia Owsley; SriniVas R Sadda; Zhihong Jewel Hu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 293. doi:

Longitudinal study of spatially localized drusen elevation changes in eyes with drusenoid pigment epithelial detachments using spectral domain optical coherence tomography Open Access

Souvick Mukherjee; Cameron Duic; Tiarnan D L Keenan; Alisa Thavikulwat; Emily Y. Chew; Catherine Cukras

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 294. doi:

Drusen Volume Change in Patients with Age-related Macular Degeneration Receiving High-Dose Atorvastatin Open Access

Augustine Bannerman; Hanna Choi; Raviv Katz; Archana Nigalye; Grace Baldwin; Filippos Vingopoulos; Deeba Husain; Joan W Miller; Demetrios Vavvas; John B Miller

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 295. doi:

Impact of High-Risk Features Associated with AMD Progression on Retinal Sensitivity Open Access

Houri Esmaeilkhanian; Muneeswar Gupta Nittala; Swetha B Velaga; David G Birch; Dwight Stambolian; SriniVas R Sadda

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 296. doi:

The influence of drusenoid pigment epithelial detachment characteristics on the progression to late-stage age-related macular degeneration Open Access

Marlene Hollaus; Johannes Iby; Jonas Brugger; Oliver Leingang; Gregor Sebastian Reiter; Ursula Schmidt-Erfurth; Stefan Sacu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 297. doi:

Prediction of Macular Morphology using a Conditional Variational Autoencoder after Full-Thickness Macular Hole Surgery Open Access

Han Jo Kwon; Iksoo Byon

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 298. doi:

Exploratory Assessment of Features Capable of Distinguishing Between Ischemic and Non-ischemic Candidate Regions in Ultra-widefield Fluorescein Angiography Open Access

Scott W. Perkins; Jon Whitney; Sari Yordi; Gagan Kalra; Sunil K Srivastava; Justis P Ehlers

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 299. doi:

Choroidal changes after anti-VEGF therapy to treat three different types of macular neovascularization in AMD eyes using swept-source OCT angiography Open Access

Giovanni Gregori; Mengxi Shen; Jie Lu; Jianqing Li; Xiaoshuang Jiang; Omer Trivizki; Rita Laiginhas; Jeremy Liu; Qinqin Zhang; Luis De Sisternes; Ruikang K Wang; Philip J Rosenfeld

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 300. doi:

Association between macular microvasculature and retinal sensitivity in Dry Age-Related Macular Degeneration : Using OCT angiography and Microperimetry Open Access

Chang Hwan Lee; Eun Kyoung Lee; Chang Ki Yoon; Taffeta Ching Ning Yamaguchi; Rolf Herrmann

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 301. doi:

Ultrasound Characteristics of Choroidal Metastases by Primary Tumor Site. Open Access

Octavio Turcio Aceves; Julian Garcia-Sanchez; Luis Antonio Antonio Rhoads Avila; Flor Angélica Jacome; Catalina Becerra Revollo; Ingrid Pita Ortiz; Daniel Moreno Páramo; Raquel Sánchez Santiago; Guillermo Salcedo-Villanueva

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 302. doi:

End-to-end design for visible light OCT denoising by speckle reduction scanning and deep learning Open Access

Tianyi Ye; Jingyu Wang; Ji Yi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 304. doi:

Comparison of macular thickness maps of a clinical SD-OCT and a low-cost self-administered OCT system Open Access

Mahsa Darvishzadeh Varcheie; Homayoun Bagherinia; Ali Fard; Ian Raden; Thomas Callan; Bryan Rogoff

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 305. doi:

Evaluation of outer retinal layers in neovascular AMD comparing High-Res OCT and SPECTRALIS OCT imaging Open Access

Veronika Röggla; Gregor Sebastian Reiter; Philipp Fuchs; Leonard Mana Coulibaly; Sophie Frank; Markus Gumpinger; Oliver Leingang; Hrvoje Bogunovic; Ursula Schmidt-Erfurth

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 306. doi:

Utilization of En Face OCT and Deep Learning-Based Automated Segmentation to Quantify Area of GA (ECLIPSE) Open Access

Samantha Orr; Jonathan Oakley; Daniel Russakoff; John Golding; Netan Choudhry

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 307. doi:

Deep learning for longitudinal OCT retinal layer thickness and AMD progression prediction Open Access

Qitong Gao; Joshua Amason; Jay Rathinavelu; Miroslav Pajic; Majda Hadziahmetovic

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 308. doi:

Predicting FTMH presence in OCT scans using a deep learning model Open Access

Kaitlyn Hunter; Timothy Wheeler; Henry He Li; Andrew Clark Thomson; Courosh Mehanian; Allan A Hunter

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 309. doi:

Exploiting data characteristics to improve automated optic nerve head segmentation and localization in OCT en face images Open Access

Thomas Schlegl; Heiko Stino; Michael Niederleithner; Kim Lien Huber; Ali Salehi; Ursula Schmidt-Erfurth; Andreas Pollreisz; Wolfgang Drexler; Rainer A Leitgeb; Tilman Schmoll

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 310. doi:

Generalizability of Convolutional Neural Network and Vision Transformer-Based OCT Segmentation Models Open Access

Adam Pely; Zhichao Wu; Theodore Leng; Simon S. Gao; Hao Chen; Mohsen Hejrati; Miao Zhang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 311. doi:

Radiomics-based assessment of Fundus Retinography (FR), optical coherence tomography (OCT) and OCT angiography (OCTA) images for Diabetes Mellitus and Diabetic Retinopathy diagnosis Open Access

Javier Zarranz-Ventura; Laura Carrera-Escale; Anass Benali; Ruben Martín-Pinardel; Carolina Bernal-Morales; Sara Marin-Martinez; Silvia Feu-Basilio; Josep Rosinés-Fonoll; Xavier Suarez-Valero; Teresa Hernández; Rafael Castro; Cristian Oliva; Irene Vila; Alfredo Vellido; Enrique Romero

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 312. doi:

OCT Super-Resolution for Data Standardization using AI: A MACUSTAR report Open Access

Coen de Vente; Adnan Tufail; Steffen Schmitz-Valckenberg; Marlene Sassmannshausen; Carel C B Hoyng; Clara I. Sánchez

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 313. doi:

Biomarker assessment for CNV development prediction in multifocal choroiditis (MFC) and punctate inner choroidopathy (PIC): A large, longitudinal, multicenter study on patients with MFC a... Open Access

Lorenzo Ferro Desideri; Mathias Gallardo; Muriel Ott; Ariel Schlaen; Debra Goldstein; H Nida Sen; Maurizio Battaglia Parodi; Vita S Dingerkus; Yael Sharon; Michal Kramer; Siqing Yu; Sandro De Zanet; Marion Ronit Munk

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 314. doi:

Automated Identification and Quantification of Ellipsoid Zone At-Risk Using Deep Learning on SD-OCT in Dry AMD Open Access

Jordan Budrevich; Sari Yordi; Gagan Kalra; Jon Whitney; Hasan Cetin; Yavuz Cakir; Jamie Reese; Sunil K Srivastava; Justis P Ehlers

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 315. doi:

Comparison of a Deep Learning based OCT image segmentation algorithm to manual segmentation by a traditional reading center for patients with wet AMD Open Access

Sparkle Russell-Puleri; Sara L Gale; Dzmitry A. Kaliukhovich; Joseph Blair; Romina Lasagni; Sandro De Zanet; Najat Khan; Daniel L Chao; Tripthi Kamath; Natasa Jovic; Anthony Pepio; H. Nida Sen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 316. doi:

Disease activity of geographic atrophy in fellow eyes of the pegcetacoplan phase III studies measured by automated AI-based OCT biomarker quantifications Open Access

Gregor Sebastian Reiter; Julia Mai; Sophie Frank; Oliver Leingang; Wolf-Dieter Vogl; Amir Sadeghipour; Hrvoje Bogunovic; Ursula Schmidt-Erfurth

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 317. doi:

Independent re-assessment of a high risk OCT feature based grading scale for early and intermediate AMD using Hawk and Harrier fellow eyes Open Access

Nadia Zakaria; Brijesh Yadav; Xueying Zhou; SriniVas R Sadda; Giulia Corradetti; Steffen Schmitz-Vlackenberg; Oliver Sander; Melissa Liew

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 318. doi:

AMD Drusen, AMD Drusenoid deposits evolving into iRORA, nGA: Morphology-Structural study with OCT and Morphology-Structural software Open Access

Corinne Gonzalez

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 319. doi:

Fully automated segmentation and quantification of the macular pigment burden detected on SS-OCTA and SD-OCT scans Open Access

Yuxuan Cheng; Gissel Herrera; Jie Lu; Jianqing Li; Ziyu Liu; Mengxi Shen; Qinqin Zhang; Jeremy Liu; Xiao Zhou; Farhan E. Hiya; Yingying Shi; Hao Zhou; Giovanni Gregori; Philip J Rosenfeld; Ruikang K Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 320. doi:

OCT Biomarkers Associated with Reading Performance in Patients with Neovascular Age-Related Macular Degeneration and Good Visual Acuity Open Access

Federico Ricardi; Giacomo Boscia; Francesco Gelormini; Valentina Marica; Fabio Conte; Francesco Bandello; Enrico Borrelli; Michele Reibaldi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 321. doi:

The two types of the foveal granular reflex in MEWDS using en face OCT Open Access

Nozomu Hashiya; Taiji Hasegawa; Ichiro Maruko; Mizuha Kakehashi; Tomohiro Iida

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 322. doi:

Education on Machine Learning-Derived OCT Biomarkers Improves Clinician Performance for Prediction of Geographic Atrophy Progression Open Access

Rachel Anderson Downes; Yavuz Cakir; Sari Yordi; Jamie Reese; Sunil K Srivastava; Justis P Ehlers

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 323. doi:

Performance comparison of macular thickness generated from a low-cost OCT with a commercial OCT system Open Access

Niranchana Manivannan; Homayoun Bagherinia; Mahsa Darvishzadeh Varcheie; Luisa Ramirez; Ali Fard

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 324. doi:

Comparison between en face structural spectral-domain and swept-source OCT angiographic scans for the detection of persistent choroidal hypertransmission defects in AMD Open Access

Gissel Herrera; Mengxi Shen; Omer Trivizki; Jeremy Liu; Yingying Shi; Farhan E. Hiya; Jianqing Li; Yuxuan Cheng; Qinqin Zhang; Giovanni Gregori; Ruikang K Wang; Philip J Rosenfeld

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 325. doi:

Combination of infrared reflectance and OCT imaging for age-related macular degeneration screening via deep learning Open Access

Felipe Salgado; LORETO CUITINO; Carla Vairetti; Fabian Vega-Tapia; Sofia Valdivieso; Sebastián Maldonado; Felipe Rojas; Alvaro Olate-Perez; Rodrigo A Valenzuela; Cristhian A Urzua

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 326. doi:

Comparison between the grading of cRORA and iRORA on SD-OCT B-scans with that of persistent hypertransmission defects on en face SS-OCT images Open Access

Ruikang K Wang; Yuxuan Cheng; Ziyu Liu; MONIKA FLECKENSTEIN; Steffen Schmitz-Valckenberg; Giovanni Gregori; Philip J Rosenfeld; Omer Trivizki

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 327. doi:

Correlation of Fundus Autofluorescence and SD-OCT Measurements of Geographic Atrophy and Overall SD-OCT Results for Geographic Atrophy Growth in the GATHER1 Clinical Trial Open Access

Conor Anthony McConville; Sari Yordi; Hasan Cetin; Gagan Kalra; Yavuz Cakir; Victoria Eileen Whitmore; Jamie Reese; Julie Clark; Liansheng Zhu; Sunil K Srivastava; Justis P Ehlers

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 328. doi:

Radiomics-based classification of OCT images of pigment epithelial detachment for prediction of anti-VEGF treatment response in eyes with wet age-related macular degeneration Open Access

Ryan Williamson; Amrish Selvam; Vinisha Sant; Manan Patel; Jose Sahel; Jay Chhablani

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 329. doi:

New OCT based definition of treatment response to anti-VEGF in treatment naive neovascular AMD patients using an Deep Learning Algorithm Open Access

Johannes Schiefelbein; Nastassya Horlava; Hannah Spitzer; Fabian Theis; Siegfried Priglinger; Ben Asani

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 330. doi:

Predicting OCT-morphological anti-VEGF treatment response in patients with neovascular age-related degeneration using artificial intelligence Open Access

Ben Asani; Nastassya Horlava; Hannah Spitzer; Fabian Theis; Siegfried Priglinger; Johannes Schiefelbein

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 332. doi:

Age-related Macular Degeneration (AMD) Staging from Routine Clinical OCT Scans using Deep Learning (DL) Open Access

Yahel Shwartz; Amit Gur; Vivian Rivkah Lender; Yaacov Cnaany; Raizy kellerman; Jaime Levi; Itay Chowers; Liran Tiosano

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 333. doi:

Generative Machine Learning Methods for OCT B scans, with Exploratory Quantitative and Qualitative Analysis Open Access

Peter Woodward-Court; Yukun Zhou; Daniel Alexander; Pearse Keane

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 334. doi:

Predicting Progression of Glaucoma based on Visual Field Tests Open Access

Jiaxing Liu; Shefali Sood; Narges Razavian; Dinah Chen; Siamak Yousefi; Tobias Elze; Gustavo De Moraes; Michael V Boland; Sarah R Wellik; Louis R Pasquale; Jonathan S Myers; Lucy Q Shen; Sumit Chopra; Lama A. Al-Aswad

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 335. doi:

Detecting and forecasting glaucoma through deep transfer learning Open Access

Yeganeh Madadi; Siamak Yousefi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 336. doi:

Building a UK Glaucoma Bioresource: a disease-specific biobank for advancing translational research in glaucoma Open Access

Tejal Magan; Julia Fajardo-Sanchez; Gerassimos Lascaratos; Faisal Ahmed; Rupert Bourne; Anthony King; Neeru Amrita Vallabh; Pouya Alaghband; Adanna Obi; Henrietta Ho; Sheng Lim; Saurabh Goyal; Ian Rodrigues; Christopher J Hammond; Cynthia Yu-Wai-Man

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 337. doi:

Retinal Surface Contour is Predictive of Fast Glaucoma Progression with Deep Learning Open Access

Yan Luo; Min Shi; Yu Tian; Mohammad Eslami; Saber Kazeminasab Hashemabad; Jessica A. Sun; Aimee C. Chang; Tobias Elze; Lucy Q. Shen; Louis R Pasquale; Nazlee Zebardast; Michael Boland; David S. Friedman; Mengyu Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 338. doi:

Diagnostic efficacy of a modified risk calculator based on the Ocular Hypertension Treatment Study (OHTS) Open Access

Michael Chaglasian; Ani Tokhmakhian; Himanee Patel; Macy Koepke; Mary Durbin; Christopher Lee

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 339. doi:

Equitable Deep Learning for Glaucoma Progression Forecasting Open Access

Mengyu Wang; Tobias Elze; Louis R Pasquale; Lucy Q. Shen; Saber Kazeminasab Hashemabad; Mohammad Eslami; Min Shi; Yu Tian; Yan Luo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 340. doi:

The Effect of Insurance Coverage Laws on Glaucoma Eyedrop Medication Use Open Access

Nicole Hehr; Patrick Barlow; Arnulfo Garza Reyes; Wisam Najdawi; Andrew Pouw

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 341. doi:

A Code-Free Neural Network for Automated Image Quality Assessment of Optic Disc Photographs Open Access

Ella Bouris; Tyler Austin Davis; Esteban Morales; Lourdes Grassi; Diana Salazar; Joseph Caprioli

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 342. doi:

Improving Glaucoma Trials Using Deep Learning to Forecast VF Variability Open Access

Jithin Yohannan; Ruolin Wang; Kaihua Hou; Patrick Herbert; Gregory Hager; Mathias Unberath; Pradeep Y Ramulu; Chris Bradley

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 343. doi:

Deep-Learning-Based Group Point-Wise Spatial Mapping of Structure to Function in Glaucoma Open Access

Zhiqi Chen; Hiroshi Ishikawa; Gadi Wollstein; Yao Wang; Joel S Schuman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 344. doi:

Impact of acquisition area on deep-learning-based glaucoma detection in OCTA Open Access

Julia Schottenhamml; Tobias Würfl; Stefan B Ploner; Lennart Husvogt; Andreas Maier; Bettina Hohberger; Christian Y Mardin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 345. doi:

Using OCT to Guide Visual Field Progression Open Access

Louay Almidani; Kaihua Hou; Chris Bradley; Pradeep Y Ramulu; Jithin Yohannan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 346. doi:

A Coarse-to-fine Model for Fundus Image Segmentation via Variational Auto-Encoder Open Access

feiyan zhang; Yuanjie Zheng; Jie Wu; Zeyuan Chen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 347. doi:

Introducing Alborz: an artificial intelligence (AI)-enabled humanoid robot with natural language processing and generation skills for assessing glaucoma Open Access

Siamak Yousefi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 348. doi:

Baseline visual field patterns identified by archetypal analysis are associated with glaucoma onset and progression in the Ocular Hypertension Treatment Study Open Access

Rishabh Singh; Yan Zhao; John H Fingert; Mae O Gordon; Michael A Kass; Yuyang Luo; Ayellet V. Segre; Janey L Wiggs; Tobias Elze; Nazlee Zebardast

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 349. doi:

The effect of achieving target intraocular pressure on optical coherence tomography worsening compared to visual field worsening Open Access

Patrick Herbert; Alex Pham; Kaihua Hou; Chris Bradley; Jithin Yohannan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 350. doi:

Automated glaucoma classification in high-resolution optic disc photographs using Computer Vision techniques and Random Forest classifier. Open Access

Md Hasnat Ali; Jisy N.K; Sirisha Senthil; Saumyadipta Pyne; M.B. Srinivas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 351. doi:

Self-supervised Learning and Self-labeling Framework for Retina Glaucoma Detection Open Access

Mina Rezaei; Amirhossein Vahidi; Bernd Bischl; Mengyu Wang; Tobias Elze; Mohammad Eslami

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 352. doi:

Replacing Mean Deviation Measured by Visual Field with Estimated Mean Deviation from Optical Coherence Tomography to Predict Glaucoma Progression Open Access

Alex Pham; Chris Bradley; Kaihua Hou; Pradeep Y Ramulu; Jithin Yohannan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 353. doi:

Association of Blood Pressure and RNFL Rates of Loss in Patients with Moderate to Advanced Glaucoma Open Access

Massood Mohammadi; Erica Su; Vahid Mohammadzadeh; Simon Law; Anne L Coleman; Joseph Caprioli; Robert E Weiss; Kouros Nouri-Mahdavi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 354. doi:

Visual Field (VF) change-based archetype analysis for early-stage glaucoma detection Open Access

Mohammad Eslami; Saber Kazeminasab Hashemabad; Min Shi; Yan Luo; Yu Tian; Nazlee Zebardast; Mengyu Wang; Tobias Elze

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 355. doi:

Visual Field Prediction using a Deep Bidirectional Gated Recurrent Unit Network Model Open Access

Hwayeong Kim; Jiwoong Lee; Sang Woo Moon; Eun Ah Kim; Sung Hyun Jo; Keunheung Park; Jeong Rye Park; Sangil Kim; Taehyeong Kim; Sang wook Jin; Jung Lim Kim; Jonghoon Shin; Seung Uk Lee; Geunsoo Jang; Yuanmeng Hu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 356. doi:

Machine learning approaches for predicting glaucoma progression in a large multicenter electronic health records consortium: the Sight Outcomes Research Collaborative (SOURCE) Open Access

Sophia Y Wang; Joshua D Stein

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 357. doi:

Automated Measurement of RNFL Thickness from OCT Scans Using a Deep Learning Segmentation Free Approach Open Access

Benton Gabriel Chuter; Justin Huynh; Mark Christopher; Ruben Gonzalez; Evan Walker; Sally L. Baxter; Akram Belghith; Christopher Bowd; Michael Henry Goldbaum; Jeffrey M Liebmann; Massimo Antonio Fazio; Christopher A Girkin; Robert N Weinreb; Linda M Zangwill

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 359. doi:

Predicting clinically significant glaucomatous visual field progression using deep learning on macular OCT Open Access

Jonathan Huang; Galal Galal; Vladislav Mukhin; Mozziyar Etemadi; Angelo Tanna

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 360. doi:

Application of a convolutional neural network fundus image quality assessment to screening data Open Access

Mary K Durbin; Shiyi Liu; Shinnosuke Azuma; Zaixing Mao; Zhenguo Wang; Tony H Ko

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 361. doi:

Multimodal Transformer Model to Detect Glaucoma from OCT and Retinal Nerve Fiber Layer (RNFL) Thickness Open Access

Justin Huynh; Ruben Gonzalez; Evan Walker; Benton Gabriel Chuter; Akram Belghith; Christopher Bowd; Michael Henry Goldbaum; Sally L. Baxter; Robert N Weinreb; Ali Tafreshi; Linda M Zangwill; Mark Christopher

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 362. doi:

A Foundational CNN Model for Predicting Eye Fixations on OCT Reports Open Access

Anurag Sharma; Ye Tian; Shubham Kaushal; Ryan Zukerman; Royce W.S. Chen; Jeffrey M Liebmann; George Cioffi; Kaveri Thakoor

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 363. doi:

Generalizable AI-based glaucoma prediction via a stable model selection method Open Access

Homa Rashidisabet; Abhishek Sethi; Ponpawee Jindarak; James Dennis Edmonds; Robison Vernon Paul Chan; Yannek Leiderman; Thasarat S Vajaranant; Darvin Yi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 364. doi:

Differentiating Multiple Sclerosis and Glaucoma with Partial Least Squares Discriminant Analysis of Peripapillary Retinal Nerve Fiber Layer Thickness Patterns Open Access

Po-Han Yeh; Elizabeth Sarah White; Ou Tan; Dongseok Choi; Aiyin Chen; Eliesa Ing; Elizabeth Silbermann; David Huang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 365. doi:

High resolution mapping of retinal nerve fibre layer thickness using hyperspectral imaging Open Access

Xavier Hadoux; Darvy Dang; Zhichao Wu; Flora Hui; Jonathan Crowston; Peter van Wijngaarden

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 366. doi:

A Performance Evaluation Method for Unsupervised OCT Phenotype Discovery using Deep Learning Open Access

Saber Kazeminasab Hashemabad; Mohammad Eslami; Sayuri Sekimitsu; Min Shi; Yan Luo; Yu Tian; Tobias Elze; Mengyu Wang; Nazlee Zebardast

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 367. doi:

Glaucoma subtyping based on visual field progression using unsupervised machine learning Open Access

Xiaoqin Huang; Asma Poursoroush; Jian Sun; Louis R Pasquale; Michael Boland; Chris A Johnson; Siamak Yousefi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 368. doi:

Esterman Virtual Reality Visual Fields in Patients with Glaucoma Open Access

Meghan Sharma; Eleonore J. Savatovsky; Alana Grajewski; Elena Bitrian

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 369. doi:

Prediction of visual field progression based on initial OCT structure measurements using Artificial Intelligence Open Access

Sasan Moghimi; Golnoush Mahmoudinezhad; V. S. Raghu Parupudi; Vyshnavi S Krishan; Siddharth Shukla; Jiacheng Cheng; Siavash Beheshtaein; Kareem Latif; Takashi Nishida; Mark Christopher; Massimo A Fazio; Jeffrey M Liebmann; Christopher A Girkin; Linda M Zangwill; Nuno Vasconcelos; Robert N Weinreb

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 370. doi:

Transformer-based Deep Learning Approach Predicts Glaucoma Surgical Intervention from OCT Open Access

Mark Christopher; Ruben Gonzalez; Justin Huynh; Evan Walker; Bharanidharan Radha Saseendrakumar; Christopher Bowd; Akram Belghith; Michael Henry Goldbaum; Massimo Antonio Fazio; Christopher A Girkin; C. Gustavo De Moraes; Jeffrey M Liebmann; Robert N Weinreb; Sally Baxter; Linda M Zangwill

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 371. doi:

Inter-rater variability in glaucoma diagnosis using optic nerve head photographs Open Access

Jayashree Kalpathy-Cramer; Saif Aldeen Alryalat; Christopher Clark; Praveer Singh; Benjamin Bearce; Sabita Ittoop; Gabriele Lazcano Gomez; Leonard Seibold; Malik Kahook

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 372. doi:

Prediction of Visual Field Progression with Optic Disc Photographs and OCT with A Deep Learning Model Open Access

Vahid Mohammadzadeh; Sean Wu; Tyler Austin Davis; Arvind Vepa; Kiumars Edalati; Jack Martinyan; Arthur Martinyan; Mahshad Rafiee; Fabien Scalzo; Joseph Caprioli; Kouros Nouri-Mahdavi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 373. doi:

Long-term rate of optic disc rim loss in glaucoma patients measured from optic disc photographs with a deep neural network Open Access

Sangwook Jin; Esteban Morales; Ella Bouris; Joseph Caprioli

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 374. doi:

Anchor-free Attention-guided Deep Neural Network for Automated Detection and Grading of Optic Nerve Axons Open Access

Kyle Freeman; Sophie Pilkinton; Madhusudhanan Balasubramanian; Shelby Graham; Monica M Jablonski

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 375. doi:

A new AI-based approach for detailed iridocorneal angle aperture assessment Open Access

Andrea Peroni; Anna Paviotti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 376. doi:

Understanding Convolutional Neural Network model decision for Glaucoma detection using Gradient class activation maps based on Compass color fundus images Open Access

Silvia Gazzina; CHIARA RUI; Dario Romano; Benedetta Colizzi; Paolo Fogagnolo; Luca Mario Rossetti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 377. doi:

Development of a Computerized and Automated Cost-Effectiveness Analysis Application to Aid in Glaucoma Surgical Management Open Access

Jaideep Prasad; Shefali Sood; Lama A. Al-Aswad

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 378. doi:

Can ChatGPT™, an "intelligent" chatbot, be used to educate our glaucoma patients? Open Access

David A Lee; Gloria Wu; Katherine Tien; Rohan Madhok; Vrinda Inani; Eddie Zhang; Jae Yong Lee; Weichen Zhao; Alaap Rag

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 379. doi:

Predicting glaucomatous visual field progression from baseline fundus photos using deep learning Open Access

Ruben Hemelings; Damon W. K. Wong; Jan Van Eijgen; Jacqueline Chua; João Barbosa Breda; Ingeborg Stalmans; Leopold Schmetterer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 380. doi:

AI in Hospital-Based Remote Glaucoma Screening: Outcomes in a Real World Setting Open Access

Afonso Vieira Lima-Cabrita; Diogo Bernardo Matos; André Diogo Barata; Carlos Marques-Neves; Ingeborg Stalmans; Luís Abegão Pinto

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 381. doi:

Presence of Medical Conditions that Can Impair Patients with Glaucoma from Administering Topical Glaucoma Medications – A Study using the Sight Outcomes Research Collaborative (SOURCE) Re... Open Access

Jaqueline Stoutin; An Hong Su; Kennedy Depperschmidt; Matthew Callewaert; Joshua D Stein

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 382. doi:

Learning Agreement Feature Based on an Information Theory for Fundus Image Segmentation Open Access

Xinbo Yang; Zhijun Zhang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 383. doi:

Standardized and Open-Access Glaucoma Dataset for Artificial Intelligence Applications Open Access

Jessica Steen; Riley Kiefer; Mahsa Ardali; Muhammad Abid; Ehsan Amjadian

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 384. doi:

Impact of AI on Retrospective Glaucoma Diagnosis Open Access

Joel Salas; Ryan Zukerman; Omar Moussa; Sophie Z. Gu; Ari Leshno; Jeffrey M Liebmann; George Cioffi; Kaveri Thakoor

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 385. doi:

Identification of patients with the higher likelihood of future vision loss Open Access

Asma Poursoroush; Xiaoqin Huang; Siamak Yousefi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 386. doi:

Predicting Surgical Interventions for Glaucoma with Clinically Available Data Open Access

Ruben Gonzalez; Justin Huynh; Evan Walker; Bharanidharan Radha Saseendrakumar; Christopher Bowd; Akram Belghith; Michael Henry Goldbaum; Massimo Antonio Fazio; Christopher A Girkin; Gustavo De Moraes; Jeffrey M Liebmann; Robert Weinreb; Sally L. Baxter; Linda M Zangwill; Mark Christopher

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 387. doi:

Classifying subjects with glaucoma and multiple sclerosis using gradient boosting machines Open Access

Elizabeth Sarah White; Po-Han Yeh; Ou Tan; Dongseok Choi; Aiyin Chen; Eliesa Ing; Elizabeth Silbermann; David Huang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 388. doi:

AxonClassNet: A Deep Learning Approach for Automated Segmentation and Grading of Retinal Ganglion Cell Axons Open Access

Shelby Graham; Kyle Freeman; Sophie Pilkinton; Madhusudhanan Balasubramanian; Monica M Jablonski

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 389. doi:

Comparison of Convolutional Neural Network for Glaucoma detection using three different input crop sizes based on Compass color fundus images Open Access

CHIARA RUI; Silvia Gazzina; Dario Romano; Benedetta Colizzi; Paolo Fogagnolo; Luca Mario Rossetti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 390. doi:

Real-World Agreement of Same-Visit Tono-Pen Versus Goldmann Applanation Intraocular Pressure Measurements Using Electronic Health Records at an Academic Medical Center Open Access

youchen zhang; Haiwen Gui; Robert Chang; Sophia Y Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 391. doi:

Ground truth validation of publicly available datasets utilized in artificial intelligence models for glaucoma detection Open Access

Ehsan Amjadian; Mahsa Raeisi Ardali; Riley Kiefer; Muhammad Abid; Jessica Steen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 392. doi:

Investigating the Risk Factors for Failure of a Minimally Invasive Goniotomy Glaucoma Surgical Device Using a Big Data Approach Open Access

Krishna Prahalad Shanmugam; Murugesan Raju; Devesh Kumar; Stephen Kwong; Jacob Vargas; Lema Noubani; Jawad Muayad; Jonathan Thomas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 393. doi:

Investigating the Risk Factors for the Failure of a Minimally Invasive Trabecular Micro-Bypass Glaucoma Device Using Electronic Health Records and a Big Data Approach Open Access

Murugesan Raju; Krishna Prahalad Shanmugam; Jayden Olson; Lakisha Haran; Shruthi Ranjithkumar; Kyoung Won Kim; Gabriella Teneyuca; Charunetha Murugesan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 394. doi:

Do Hispanic Patients Who Require a Medical Interpreter Understand the Severity of Their Glaucoma Diagnosis Open Access

Sophia Bertot; Louis Cantor

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 395. doi:

Ocular Phenotype Variations in Patients with PAX6 and Associated Gene Variants Open Access

David N Younessi; Brenda Bohnsack; Adam jacobson; Alex Ing; Andy Drackley; Valerie Castelluccio; hanta ralay-ranaivo; Jennifer Rossen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 396. doi:

Variants in histone lysine methyltransferases resulting in Axenfeld-Rieger and Peters-plus like phenotypes. Open Access

Linda Reis; Huban Atilla; Peter Kannu; Adele Schneider; Samuel Thompson; Tanya Bardakjian; Elena V Semina

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 397. doi:

Skewed X-chromosomal inactivation causes ciliary mis-localization of RPGR and retinal dystrophies in female carriers of RPGR mutations. Open Access

John Neidhardt; Muhammad Usman; Fei Song; Jannis Eilers; Dennis Kastrati; Heymut Omran; Laurenz Pauleikhoff; Clemens Lange

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 398. doi:

Qualifications for Gene-Replacement Therapies in patients with Retinitis Pigmentosa and Leber Congenital Amaurosis Open Access

Richard Norman Sather III; Jacie Ihinger; Michael Simmons; Tahsin Khundkar; Sandra Rocio Montezuma

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 399. doi:

Challenges of common variants for risk assessment and genetic counseling of inherited retinal diseases Open Access

Molly Marra; Emma Bedoukain; Kaitlin O’Connell; Emily Place; Michelle Alabek; Erin O'Neil; Tomas S Aleman; Drew Scoles; Jason Comander; Rachel M Huckfeldt; Boris Rosin; Jose Sahel; Lesley Everett; Paul Yang; Mark E Pennesi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 400. doi:

Genetic characteristics, genotype-phenotype correlation, and pilot treatment findings for Leber congenital amaurosis (LCA) in Taiwan Open Access

Ta-Ching Chen; Meng-Chieh Duh; Yu-Shu Huang; Yi-Chieh Chen; Chung-May Yang; Chang-Hao Yang; Jacob ShuJui Hsu; Pei-Lung Chen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 401. doi:

Inherited Retinal Disease Genetic Testing is Dynamic!– Snapshot of 5 years of a Midwest academic practice with dedicated Inherited Retinal Disease Clinics. Open Access

Kimberly E Stepien; Rachel Sullivan; Elizabeth Kellom; Kyle Peterson; Nickie Stangel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 402. doi:

Visualizing the global lens epithelial cell injury response Open Access

SUHOTRO GORAI; Adam Pater Faranda; Melinda K. Duncan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 403. doi:

Effects of age and ovariectomy on ECM and TGF-b signaling gene sets in Brown Norway rat scleras Open Access

Cydney Wong; Gabriela Sánchez-Rodríguez; C Ross Ethier; Levi Wood; Andrew J. Feola

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 404. doi:

Transcriptomic Analysis of Retinal Pigment Epithelium Reveals Potential Injury Mechanisms Associated with Pentosan Polysulfate Treatment Open Access

Victor Correa; Dimitrios Ntentakis; Toshio Narimatsu; Demetrios Vavvas; Nikolaos Efstathiou

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 405. doi:

Age and Ovariectomy affect retinal gene expression of TGF-β, TNF-α and ECM related pathways Open Access

Gabriela Sanchez; Cydney Wong; Levi Wood; Andrew J. Feola

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 406. doi:

Differential GABA receptor gene expression and risk for primary open angle glaucoma Open Access

John H Fingert; Adam Hedberg-Buenz; Floyd Evans; Michael Anderson; Robert Mullins

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 407. doi:

Investigating the role of mir-205-5p in cell migration processes Open Access

María Ybarra Sánchez; Miriam Martínez Santos; María Oltra; Francisco Javier Sancho Pelluz; Jorge M Barcia

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 408. doi:

Downregulation of miR-205-5p in ARPE-19 promotes angiogenesis in HUVEC cell Open Access

Miriam Martínez Santos; María Ybarra Sánchez; María Oltra; Francisco Javier Sancho Pelluz; Jorge M Barcia

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 409. doi:

Domain specific regulation of Wingless (Wg) signaling by novel eye patterning gene defective proventriculus (dve) determines eye vs. head specific fate Open Access

Amit Singh; Anuradha Venkatakrishnan Chimata; Oorvashi Roy Puli; Neha Gogia; Rohith Basavanahalli Nanjundaiah; Takeshi Yorimitsu; Hideki Nakagoshi; Madhuri Kango-Singh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 410. doi:

Mouse strain differences in development of glucocorticoid-induced ocular hypertension Open Access

Pinkal D Patel; Gaurang Patel; Eldon E Geisert; J Cameron Millar; Abbot F Clark

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 411. doi:

A mouse model of human Congenital Stationary Night Blindness (CSNB) for therapeutic evaluation Open Access

Bikash R Pattnaik; Pawan K Shahi; Meha Kabra

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 412. doi:

Heritable Risk and Protective Genetic Components of Glaucoma Medication Nonadherence Open Access

Julie Barr; Michael Feehan; Casey Tak; Leah Owen; Patrice Marie Hicks; Elizabeth D. Au; Michael H Farkas; Asher Weiner; Andrew L. Reynolds; Sandra Sieminski; Richard Sherva; Mark M Munger; Murray H Brilliant; Margaret M DeAngelis

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 413. doi:

Strategies for Readthrough of Premature Termination Codons to Restore Ion Channel Function Open Access

Stephen Fulbright; Meha Kabra; Pawan K Shahi; Allison Spillane; Christopher Ahern; Bikash R Pattnaik

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 414. doi:

Biophysical and Functional Characterization of Recombinant Human Lubricin Proteins: rhPRG4 vs ECF843 Open Access

Nikhil Menon; Adam Tanguay; Libo Zhou; Ling Zhang; Cedric Bobst; Mingyu Han; George Wren Greene; Alix Deymier; Benjamin Sullivan; Yupeng Chen; Gregory Jay; Tannin A Schmidt

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 415. doi:

Iron exacerbates retinal pigment epithelial bisretinoid toxicity in vivo Open Access

Brandon Anderson; Brent Bell; Ying Song; Timothy Lee; Sierra Foshe; Janet Sparrow; Joshua Dunaief

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 416. doi:

Differential cellular release of alarmins (DAMPs) by conjunctival and corneal epithelial cells in hyperosmolar context leads to an inflammatory response of macrophage: test of specific me... Open Access

Loic Blanchon; Fanny HENRIOUX; Audrey Antoine; Coline Charnay; Valentin Navel; Corinne Belville; Frederic Chiambaretta; Vincent SAPIN

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 417. doi:

Targeting the Nfe2l1 pathway to Delay Vision Loss Open Access

Yixiao Wang; Aaron Snell; Elizabeth Colvin; Frank Dyka; Cristhian J Ildefonso; John Ash; Ekaterina S Lobanova

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 419. doi:

Therapeutic targeting of glycolytic enzyme, PKM2, in proliferative vitreoretinopathy Open Access

Moloy Goswami

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 420. doi:

Usher syndrome 1C protein harmonin suppresses canonical Wnt-signaling providing novel insights into the pathophysiology of USH1C Open Access

Uwe Wolfrum; Jessica Schäfer; Nicole Wenck; Katharina Janik; Joshua Linnert; Vanessa Neumer; Joshua Klein; Katarina Stingl; Susanne Kohl; Nikolai Klymiuk; Kerstin Nagel-Wolfrum

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 421. doi:

Rs1^-/Y rat exon-1-del rat model of X-linked retinoschisis shows INL cellular irregularities and ILM barrier breaks Open Access

Serafina Thomas; Zeljka Smit-McBride; Ning Sun; Paul A Sieving

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 422. doi:

An abundance of follicular helper T cells in peripheral blood associated with thyroid stimulating immunoglobulin level in the thyroid eye disease Open Access

Hemlata Bisnauthsing; Hoi Ying Emily Chan; Hin Yin Matthew Chan; Ching Yau Shannon So; Wan Xue Chen; Him Kwan Ng; Shing Chak Jonathan Cheng; Calvin C P Pang; Clement C. Tham; Kam-lung, Kelvin Chong; WAI KIT CHU

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 423. doi:

Role of macrophages in choroidal aging and L-ORD pathology Open Access

Manisha Dagar; Pooja Biswas; Julie P. Singh; Anne Marie Berry; Danielle Lazaro; Donita Garland; Radha Ayyagari

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 424. doi:

Choroid mast cells in aging and late onset retinal degeneration (L-ORD) Open Access

Donita Garland; Manisha Dagar; Anne Marie Berry; Danielle Lazaro; Pooja Biswas; Radha Ayyagari

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 425. doi:

AMD-linked variant B cystatin C interacts with mitochondrial proteins in retinal pigment epithelium cells Open Access

Luminita I Paraoan; Emil Carlsson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 426. doi:

Targeting the IGF-1/IGF-1R signaling in uveal melanoma inhibits cell survival, cell migration and reduces tumor growth. Open Access

Chandrani Chattopadhyay; Rajat Bhattacharya; Jason Roszik; Hugo Villanueva; Gabrielle Wells; Elizabeth Grimm

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 427. doi:

Assessment of increase in Omega -3 index with various nutritional supplements Open Access

Pinakin Gunvant Davey; Cesar Ochoa; Edith Avita; Vrutti Mehta; Stephanie Amonoo-Monney; Frank Spors

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 428. doi:

Evidence of clonal expansion among vitreous-derived T-cells in birdshot chorioretinopathy: A single cell profiling-based molecular case study Open Access

Wen Fury; Sunil K Srivastava; Charles Miller; Christina Adler; Sumit Sharma; Kimberly Baynes; Ashley Lowe; Danielle X Burton; Bolisa Hang; Peter Kaiser; Santiago Patricio Mendez Huergo; Raquel Deering; Min Ni; Yi Wei; Mickey Atwal; Johnathan Weyne

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 429. doi:

Conditional deletion of NMNAT1 in the murine cone photoreceptor leads to severe cone degeneration with distinct neural circuitry defects Open Access

Saminathabn Ramasamy; Saravanan Kolandaivelu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 430. doi:

Elovanoid N34:6 selectively interacts with cytosolic TXNRD1 to promote cell survival in RPE cells Open Access

Jorgelina Muriel Calandria; Surjyadipta Bhattacharjee; Sayantani Kala-Bhattacharjee; Nicolas G Bazan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 431. doi:

Effect of Lens Thickness on Performance of the Barrett Universal II and Hill-RBF Formulas Amongst Diabetics Open Access

Ema V Karakoleva; Rucha K Borkhetaria; Nitya Devireddy; Erik B Lehman; Seth Pantanelli

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 432. doi:

Prevalence of Visually Significant Cataract and Unmet Need for Cataract Surgery in African Americans Open Access

Bruce Burkemper; Roberta McKean-Cowdin; Xuejuan Jiang; Kaili Ding; Mina Torres; Rohit Varma

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 434. doi:

Six-Month Clinical Outcomes with Bilateral Mix-and-match Implantation of Extended Depth of Focus and Trifocal Intraocular Lenses Open Access

Jae Yong Kim; Hye Rin An; Sanghyu Nam; Ko Eun Lee; Hun Lee; Hungwon Tchah

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 436. doi:

WITHDRAWN_SICS Resident Training Survey Open Access

Clayton Grundvig; John Welling; Akwasi Ahmed; Dzigbodi Damashie

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 437. doi:

Effect on driving performance of a new inverted meniscus-shaped intraocular lens Open Access

Sonia Ortiz-Peregrina; Miriam Casares-López; Consuelo Robles; Lucía Hervella; Encarna Alcon; José J Castro-Torres; Rosario G Anera; Jose M Marin; Pablo Artal

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 441. doi:

Assessment of refractive methodologies in patients implanted with extended depth of focus intraocular lenses (EDF IOLs) Open Access

Eric Li; Srividhya Vilupuru; Aixa Alarcon; Mark Hoffman; Daniel Black; Nicole Smith; Wright Shamp

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 442. doi:

Refractive Outcomes of Cataract Surgery in Eyes with Prior Scleral Buckling Open Access

Rucha Borkhetaria; Nitya Devireddy; Ema V Karakoleva; Seth Pantanelli

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 443. doi:

Complications of Cataract Surgery in Eyes With History of Scleral Buckling Open Access

Nitya Devireddy; Rucha Borkhetaria; Ema V Karakoleva; David B Rosen; Seth Pantanelli

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 444. doi:

Visual outcomes of bilaterally blind patients undergoing cataract surgery across seven developing world countries Open Access

Suyoung Choi; Arthur abrant; Suzann Pershing; Natasha Gonzalez; Akwasi Ahmed; Andrew DesLauriers; Geoff C. Tabin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 445. doi:

Visual outcomes of hundred thousand cataract surgeries performed at a network of rural eye centres in India Open Access

Varsha Rathi; Rohit Chandramohan Khanna

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 446. doi:

Combinative Approach of Transzonular Triamcinolone-Moxifloxacin and Perioperative Drops to Minimize Postoperative Complications of Cataract Surgery Open Access

Behnam Rabiee; Muhamad Festok; Michael Gaspari; Abid Haseeb; Aaila Chaudhry; Layla Kamoun; Imtiaz Chaudhry; Iftikhar Chaudhry

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 447. doi:

Long term change in refractive error after cataract extraction and intraocular toric lens implantation in a veteran population Open Access

Sydney Roston; J. Erik Kulenkamp; Abdurahman Ahmed; Ryan Scheurer; Karen R Armbrust

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 448. doi:

Three Month Outcomes After Bilateral Mix-and-match Implantation of Extended Depth of Focus and Trifocal Intraocular Lenses Open Access

Hyunah Lim; Ko Eun Lee; Joon Hyuck Jang; Sanghyu Nam; Hun Lee; Hungwon Tchah; Jae Yong Kim

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 449. doi:

Complications of cataract surgery and prolonged anesthesia recovery at an academic center Open Access

Amanda Lu; Zhuang Fang; Theodora Wingert; John Bartlett

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 450. doi:

Preoperative visual acuity changes among cataract surgery patients Open Access

Thanvi Vatti; David Donghan Chong; Christopher Maatouk; Steve Wahied Gendi; Rishi Singh; Katherine Talcott

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 451. doi:

Retrobulbar anesthesia for ophthalmic surgery: A 10-year retrospective analysis Open Access

Modupe Olufunmilayo Adetunji; Jullia Rosdahl

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 452. doi:

Clinical and molecular characterization of foveal hypoplasia Open Access

Sarah Hull; Jay Kumar; Andrea L Vincent

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 453. doi:

Minimal Image Gain as an objective measurement for vitreous hemorrhages: Comparison of resolved versus persistent VH Open Access

Julian Garcia-Sanchez; Luis Antonio Antonio Rhoads Avila; Flor Angélica Jacome; Guillermo Salcedo-Villanueva

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 454. doi:

Bidirectional retinal oculomics in Parkinson’s disease: A cross-sectional analysis of two cohorts Open Access

Siegfried Wagner; David Romero-Bascones; Mario Cortina Borja; Dominic Williamson; Robbert Struyven; Yukun Zhou; Paul Foster; Unai Ayala; Miatane Barrenechea; Iñigo Gabilondo; Anthony Khawaja; Praveen J Patel; Jugnoo Rahi; Alastair K Denniston; Axel Petzold; Pearse Keane

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 455. doi:

Precisely Mapping Choroidal Tumour Margins Open Access

Roderick O'Day; Xavier Hadoux; Darvy Dang; Peter van Wijngaarden

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 456. doi:

Foveal phenotypes on adaptive optics scanning light ophthalmoscopy in choroideremia Open Access

Niamh Wynne; Yu You Jiang; Jessica Ijams Wolfing Morgan; Tomas S Aleman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 457. doi:

Relation between choroidal blood flow parameters and systemic atherosclerosis in patients with acute coronary syndrome Open Access

Taiji Nagaoka; Yasunari Ebuchi; Akifumi Kushiyama; Daisuke Fukamachi; Harumasa Yokota; Satoru Yamagami; Yasuo Okumura

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 458. doi:

Retinal biomarkers for systemic diseases: an oculome-wide association study in 164,784 individuals Open Access

Timing Liu; Siegfried Wagner; Robbert Struyven; Yukun Zhou; Dominic Williamson; David Romero-Bascones; Mateo Gende Lozano; NIKOLAS PONTIKOS; Praveen J Patel; Mario Cortina Borja; Jugnoo Rahi; Axel Petzold; Anthony P Khawaja; Alastair K Denniston; Konstantinos Balaskas; Pearse Keane

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 459. doi:

Ixoberogene soroparvovec (Ixo-vec) for the treatment of neovascular age-related macular degeneration: Nonclinical data in support of human equivalent dose of 6E10 vg/eye and staggered bil... Open Access

Kris Poulsen; Kelly Hanna; Kellie Schaefer-Swale; Julio Nieves; Charles Engbers; Ngoc Nguyen; Aivan Nguyen; Joseph Yu; Scott Duncan; Diana Cepeda; Kristina Oresic Bender; Szilard Kiss; Ruslan Grishanin; Brigit Riley

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 460. doi:

Intravitreal aflibercept 8 mg injection in patients with neovascular age-related macular degeneration: 48-week results from the Phase 3 PULSAR trial Open Access

Martin Stephan Spitzer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 461. doi:

Two-year results from a global observational study investigating proactive dosing regimens with intravitreal aflibercept in neovascular age-related macular degeneration (nAMD) in routine ... Open Access

Clare C Bailey; Varun Chaudhary; Paul Mitchell; Se Woong Kang; Ramin Tadayoni; Helmut Allmeier; JinKyung Lee; Xin Zhang; Tobias Machewitz; Jean-Francois Korobelnik

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 462. doi:

Intravitreal vascular endothelial growth factor inhibition associates with decreased risk of all-cause mortality in patients with neovascular aged-related degeneration Open Access

Benjamin Thinggaard; Katrine Hartmund Frederiksen; Yousif Subhi; Soren Moller; Ryo Kawasaki; Jakob Grauslund; Lonny Stokholm

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 463. doi:

Phase III Randomized Clinical Trial Comparing SB15 with Reference Aflibercept in Neovascular Age-Related Macular Degeneration Open Access

SriniVas R Sadda; Se Joon Woo; Mario Bradvica; Attila Vajas; Min Sagong; Jan Studnicka; Edward Wylegala; Cheolmin Yun; Michal Orski; Sergei Astakhov; Edit Tóth-Molnár; Adrienne Csutak; Lajos Enyedi; Taehyung Kim; Inkyung Oh; Hyerin Jang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 464. doi:

Disease control at week 16 of brolucizumab in adult patients with suboptimal anatomically controlled neovascular age related macular degeneration – the SWIFT study Open Access

Ramin Tadayoni; Eric Souied; Catherine Creuzot-Garcher; Salomon Y Cohen; Laurent Kodjikian; Stephanie Baillif; Marie-Noelle Delyfer; Michel Weber; Isabelle Aubry-Quenet; Anne Ponthieux; François Devin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 465. doi:

Six-month Outcomes of Brolucizumab in Routine Clinical Practice: Data from the Fight Retinal Blindness! Registry Open Access

Mark Gillies; trung dang; Vuong Nguyen; Alessandro Invernizzi; Francesco Romano; Mariano Cozzi; Jennifer Arnold; james wong; hemal mehta; samantha Fraser-Bell; Richard Barry; Daniel Barthelmes; Alan Luckie

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 466. doi:

Near-infrared adaptive optics fluorescence lifetime ophthalmoscopy of human retinal pigment epithelium reveals variations with eccentricity and disease Open Access

Karteek Kunala; Janet Anne Hrdina Tang; Kristen E Bowles Johnson; Khang T Huynh; Keith Parkins; Qiang Yang; Jennifer J. Hunter

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 467. doi:

Preferred Retinal Locus of Fixation in the S-cone Pathway Open Access

Yiyi Wang; BaoChau T. Vu; Congli Wang; Ren Ng; William Scott Tuten

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 468. doi:

S-cone isolating acuity in subjects with spectrally classified cone mosaics Open Access

Emily Slezak; Palash Bharadwaj; Vimal Prabhu Pandiyan; Daniel R. Coates; Ramkumar Sabesan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 469. doi:

AO-OCT optoretinography reveals photopigment density variation among individual cone photoreceptors in the living human eye Open Access

Marcel Bernucci; Yan Liu; Kazuhiro Kurokawa; James Alan Crowell; Qiuzhi Ji; Donald Thomas Miller

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 470. doi:

Comparison of cone spectral composition between fellow eyes of color normal subjects Open Access

Vimal Prabhu Pandiyan; Sierra Ashley Schleufer; Ramkumar Sabesan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 471. doi:

Parafoveal Cone Function in Choroideremia Assessed with Optoretinography Open Access

Peiluo Xu; Robert F Cooper; Yu You Jiang; Jessica Ijams Wolfing Morgan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 472. doi:

Intrinsic signal optoretinography of early photoreceptor abnormality in Alzheimer’s disease mice Open Access

Guangying Ma; Xincheng Yao

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 473. doi:

Epigenetic reprogramming- A novel gene therapy that restores vision loss in a nonhuman primate model of NAION Open Access

Bruce Ksander; Madhura Shah; Drenushe Krasniqi; Meredith S Gregory-Ksander; Sharon Rosenzweig-Lipson; Kasia Broniowska; Michel Wathier; Joan Mannick; Jennifer Cermak; Margarete Karg; Shintaro Shirahama; Nasrin Refaian; Yuancheng Lu; Matthew Lawrence; Joseph F. Rizzo; David Sinclair

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 474. doi:

Nonhuman primate model of Usher Syndrome Type 1B: course of retinal degeneration and initial gene therapy results Open Access

Lauren Renner; Junghyun Ryu; Jon D Hennebold; Sanford L Boye; Carol Hanna; Fernanda Burch; Beth Kempton; Edward V Porsov; Rachel Spears; Benjamin Burwitz; Andreas K Lauer; David Wilson; Mark E Pennesi; Shannon Boye; John V Brigande; Martha Neuringer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 475. doi:

Metformin Attenuates the Hallmarks of Stargardt Disease Open Access

Mitra Farnoodian; Francesca Barone; Marisa Boyle; Rishabh Gupta; Luke Matthew Nelson; Devika Abhijit Bose; Bokkyoo Jun; William C Gordon; Khanh V Do; Marie-Audrey Kautzmann Guerin; Tiziana Cogliati; Peter Walter; Laryssa Huryn; Nicolas G Bazan; Brian Patrick Brooks; Kapil Bharti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 476. doi:

Pre-clinical efficacy testing of AAV-based gene therapy for KCNV2-deficiency. Open Access

Livia Carvalho; Rabab Rashwan; Xin Ru Lim; Alicia Brunet; Annie Laura Miller; Yashvi Bhatt; Paula Fuller-Carter; David Hunt

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 477. doi:

Molecular insights and treatment of IFT140-mediated retinal dystrophy in iPSCs-derived retinal organoids and RPE Open Access

Julio Cesar Corral Serrano; Nele Schwarz; Karsten Boldt; Katarina Jovanovic; Daniele Ottaviani; Isabelle Perrault; marius ueffing; Michael E Cheetham

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 478. doi:

Human stem cell-derived retinal organoids to resolve novel missense and intronic variants of uncertain significance and test novel therapies in the inherited retinal dystrophies Open Access

Robyn V Jamieson; To Ha Loi; Fidelle Chahine Karam; John R Grigg; Anson Cheng; Benjamin M Nash

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 479. doi:

An Open-access Web-based System for Inherited Retinal Disease Education Open Access

Edwin M Stone; Adam P DeLuca; Jeaneen L Andorf; Ben P Faga; Laurel A Faga; Louisa M Affatigato; Jeremy M Hoffmann; Douglas B Critser; Nicholas D Lessing; Terry A Braun; Todd E Scheetz

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 480. doi:

Regional Gene Expression the Retina, Optic Nerve Head and Optic Nerve in Mice with Experimental Glaucoma and Optic Nerve Crush Open Access

Harry A Quigley; Casey J. Keuthan; Sarah Quillen; Thomas Johnson; Meihan Wei; Weixiang Fang; Elizabeth Kimball; Hongkai Ji; Donald J Zack

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 481. doi:

Calcium clearance deficits linked to endoplasmic reticulum stress are signature features of early retinal ganglion cell damage in glaucoma Open Access

Yukihiro Shiga; Aline Giselle Rangel Olguin; Sana El Hajji; Nicolas Belforte; Heberto Quintero; Florence Dotigny; Luis Alarcon-Martinez; Arjun Krishnaswamy; Adriana Di Polo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 482. doi:

Primary open angle glaucoma patients have lower systemic mitochondrial function, associated with lower systemic nicotinamide adenine dinucleotide (NAD) levels, compared to Controls Open Access

Bledi Petriti; Alessandro Rabiolo; Pete Williams; Kai-Yin Chau; Gerassimos Lascaratos; David F Garway-Heath

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 483. doi:

Quantitative proteomic analysis reveals differential responses of glial cells and retinal neurons between primary and secondary retinal ganglion cell degeneration Open Access

Jacky Man Kwong Kwong; Joseph Caprioli; Feng-Juan Yu; Jingfang Bian; Ying Hong Sze; King Li; Chi-wai Do; Chi-ho To; Thomas Chuen Lam

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 484. doi:

Retinal ganglion cells adapt to ionic stress in experimental glaucoma Open Access

Andrew Boal; Nolan McGrady; Joseph Holden; Michael Risner; David J Calkins

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 485. doi:

Large scale excitatory and inhibitory synapse detection using deep learning in an experimental mouse model of glaucoma Open Access

Luca Della Santina; Yvonne Ou

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 487. doi:

Genetic and pathologic predictors of progression from early to advanced age-related macular degeneration Open Access

William K Scott; Susan H. Slifer; Kyle M. Scott; Stephen G Schwartz; Jaclyn L. Kovach; SriniVas R Sadda; Muneeswar Gupta Nittala; Jonathan L Haines; Margaret A Pericak-Vance

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 488. doi:

Genome-wide association study of epiretinal membrane in the Finnish population identifies novel associated genes that are expressed in patient-derived pathologic membranes Open Access

Elizabeth Rossin; Joel T Ramo; William Phillip Miller; Romy Bejjani; Lucia Sobrin; Demetrios G. Vavvas; John B Miller; Xin Wang; Mark Daly; Dean Eliott; Aarno Palotie; Leo A Kim

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 489. doi:

Genome-wide association study for primary angle closure glaucoma in Europeans identifies novel loci related to iris colour and morphology Open Access

Robert Luben; Mahantesh Biradar; Kelsey Stuart; Siegfried Wagner; Alasdair Warwick; Zihan Sun; Kian Madjedi; Paul Foster; Chiea Chuen Khor; Tin Aung; Pirro G Hysi; Anthony Khawaja

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 490. doi:

From Genome to Phenome: Novel Cross-Ancestry Evaluation of Glaucoma Genetic Risk in the Million Veteran Program Open Access

Andrea R Waksmunski; Tyler G Kinzy; Lauren A Cruz; Cari L Nealon; Christopher W Halladay; Paul Greenberg; Wen-Chih Wu; Sudha K Iyengar; Dana C Crawford; Neal S Peachey; Jessica Cooke Bailey

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 491. doi:

Comparison of multiple polygenic risk score derivation approaches for population-level prediction of primary open-angle glaucoma Open Access

Mahantesh Biradar; Robert Luben; Kelsey Stuart; Alasdair Warwick; Zihan Sun; Mark Chia; Paul Foster; Pirro G Hysi; Anthony Khawaja

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 492. doi:

Investigating genetic causality with a high throughput splicing assay Open Access

Kinga Maria Bujakowska; Hilary Scott; Emily Place; Evelyn Harper; Sudeep Mehrotra; Rachel M Huckfeldt; Jason Comander; Eric A Pierce

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 493. doi:

GWAS-by-Subtraction unveil the genetic architecture of non-IOP-dependent mechanism in POAG Open Access

Yu Huang; Denis Plotnikov; Danli Shi; Cong Li; Xiayin Zhang; Xueli Zhang; Xianwen Shang; Shulin Tang; Zhuoting Zhu; Honghua Yu; Jeremy A Guggenheim; Mingguang He

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 494. doi:

Inverse Risk for Progression of Diabetic Retinopathy and Age-Related Macular Degeneration Open Access

Ward Fickweiler; Cris Martin P. Jacoba; Surya Jangolla; John Gauthier; Nolan Ziemniak; I-Hsien Wu; Jerry cavallerano; Lloyd P Aiello; Jennifer K Sun; George L King

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 495. doi:

NLRP3 inflammasome priming in the retina of diabetic mice requires REDD1-dependent activation of GSK3 Open Access

Christopher Michael McCurry; Siddharth Sunilkumar; Allyson Toro; Ashley VanCleave; Michael D. Dennis

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 496. doi:

AEBP1 modulates pericyte-myofibroblast transdifferentiation in proliferative diabetic retinopathy Open Access

Katia Corano Scheri; Jeremy A Lavine; Benjamin Robert Thompson; Amani A Fawzi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 497. doi:

Akt2 signaling in RPE contributes to retinal fibrosis in DR Open Access

Haitao Liu; Vishnu Maddipatla; Sayan Ghosh; Victoria Koontz; Stacey L Hose; J. Samuel Zigler Jr.; Debasish Sinha

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 498. doi:

Lysyl oxidase promotes neutrophil cytotoxicity towards retinal endothelial cells in diabetes Open Access

Mahesh Agarwal; Sathishkumar Chandrakumar; Irene Santiago Tierno; Adrita Chandra; Emma M Lessieur; Timothy S Kern; Kaustabh Ghosh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 499. doi:

Single-nuclei RNA sequencing of the diabetic mouse retina reveals dysregulation of neurexins in early diabetic retinal disease Open Access

Mira Menon Sachdeva; Ruth Marx-Rattner; Madhu S Saddala; Shinwon Ha; Kaitlyn Clark; Dongsan Kim; Sung-Ung Kang; Jiang Qian; Valina L Dawson; Ted M Dawson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 500. doi:

Altered protein expression in the diabetic human macula Open Access

Silke Becker; Frans Vinberg

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 501. doi:

C-X-C chemokine receptor type 5 (CXCR5) influences corneal wound healing in vivo Open Access

Rajiv R Mohan; Praveen Balne; Suneel Gupta; Nishant R. Sinha; Chase Jeffery; Ratnakar Tripathi; Laila A Suleiman; Eric Zhang; Prashant R. Sinha

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 502. doi:

Characterization of Corneal Fibrosis in Young versus Adult Mice Following Mechanical Injury Open Access

Hamid Alemi; Shudan Wang; Katayoon Forouzanfar; Shima Dehghani; Elsayed Elbasiony; Francesca Kahale; Thomas H Dohlman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 503. doi:

Detailed Corneal Characteristics with Swept-Source Optical Coherence Tomography in Patients with Macular Corneal Dystrophy Open Access

Anna Nowinska; Slawomir Teper; Edward Wylegala

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 504. doi:

In vitro quality screening of human corneal stromal stem cells for cell-based therapy of corneal scarring Open Access

Gary Hin-Fai Yam; Mithun Santra; Yiqin Du; Deepinder K. Dhaliwal; Vishal Jhanji

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 505. doi:

Role of Lumican on TgfβR Signaling in The Healing of Deep Corneal Epithelial Debridement Open Access

Winston Kao; Jianhua Zhang; Shingo Yasuda; Yong Yuan; Shizuya Saika; chia-yang liu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 506. doi:

Progressive Corneal Edema and Loss of the Antioxidant lncRNA Neat1 in a Novel Slc4a11^+/W214S Mouse Model of Late-Onset Fuchs Endothelial Corneal Dystrophy Open Access

Mark Parker; Sangita P Patel; Aniko Marshall; Bianca Quade

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 507. doi:

Ocular surface neutrophils are morphologically distinct in keratoconus Open Access

Pradipta Bhattacharya; Alan R Burns; Maria Walker

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 508. doi:

Molecular characterizations and comparisons of retinal cell types among human and non-human primates Open Access

Yi-Rong Peng

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 509. doi:

Diverse novel ganglion cell and amacrine cell types in the macaque and human retina revealed with large-scale recordings Open Access

E.J. Chichilnisky

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 510. doi:

Light signaling in the human macula Open Access

Frans Vinberg

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 511. doi:

Retinal Ganglion Cell Diversity in the Primate Fovea Open Access

Sara Patterson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 512. doi:

Functional diversity in understudied ganglion cells of the primate retina Open Access

Michael B. Manookin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 513. doi:

Cell type-Specific Functions of the miR-183/96/182 Cluster in the Cornea Open Access

Naman Gupta; Sharon McClellan; Mallika Somayajulu; Ahalya Pitchaikannu; Linda D Hazlett; Shunbin Xu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 514. doi:

IL-6/IL-6R Axis-mediated Treg Loss of Function Enhances Dendric Cell Immunostimulatory Function and Corneal Graft Failure Open Access

Tomas Blanco; Seokjoo Lee; Shima Dehghani; Akitomo Narimatsu; Hamid Alemi; Katayoon Forouzanfar; Thomas H Dohlman; Yihe Chen; Reza Dana

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 515. doi:

Adoptive Transfer of Third-Party Plasmacytoid Dendritic Cells Promote Allograft Survival in a Murine Model of Allogeneic Corneal Transplantation Open Access

Fangfang Qiu; Brendan Kenyon; Deshea L Harris; Pedram Hamrah

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 516. doi:

A Th1-skewed immune response in the ocular surface favors corneal nerve damage Open Access

Alexia Vereertbrugghen; Manuela Pizzano; Florencia Sabbione; Irene Angelica Keitelman; Carolina Maiumi Shiromizu; Douglas Vera; Federico Fuentes; Mirta Nilda Giordano; Analía Trevani; Jeremias Gaston Galletti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 517. doi:

The miR-183/96/182 Cluster Is a Checkpoint of Resident Immune Cells and Shapes the Cellular Landscape of the Cornea Open Access

Shunbin Xu; Weifeng Li; Katherine Gurdziel; Ahalya Pitchaikannu; Naman Gupta; Linda D. Hazlett

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 518. doi:

Transcriptomic analysis of lens epithelial explants lacking Fgfrs and Pten Open Access

Michael L Robinson; Brad D. Wagner; Anthony Petulla; Anil Upreti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 520. doi:

The oculoauricular syndrome gene Hmx1 is required for lens epithelial cell proliferation and differentiation Open Access

Xiuqian Mu; Fuguo Wu; Jianyi Lyu; Nan Nan; Jie Wang; Tao Liu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 521. doi:

Multiomic analysis of HIF1a binding, regulation and gene expression combined with characterization of novel lens conditional HIF1a KO mice reveals essential requirements for hypoxia and H... Open Access

Joshua Disatham; Lisa A Brennan; Michael L Robinson; Marc Kantorow

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 522. doi:

Role of Caspases in the Process of Nuclear Removal Open Access

Rifah Gheyas; A Sue Menko

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 523. doi:

Regulation of lens epithelial cell heterogeneity and lens growth by Connexin 50 Open Access

Chun-hong Xia; William Lin; Taishi Painter; Chenxi Ou; Xiaohua Gong

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 524. doi:

Receptor EphA2 canonical and non-canonical signaling in the lens Open Access

Catherine Cheng; Jackson T Clark; Michael P Vu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 525. doi:

AlphaA-Crystallin Suppresses DBC1, A Negative Regulator of SIRT1 to Repress Stress-Induced Apoptosis of Lens Epithelial Cells Open Access

Yan Wang; Jialing Fu; Shuyu Zheng; Jingmiao Wang; yuan xiao; LAN ZHANG; Xuebin Hu; yuwen gan; Xingmiao Liang; David W Li

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 526. doi:

Amblyopia disrupts balanced ocular dominance (OD) activity in humans Open Access

Shahin Nasr; Jan Skerswetat; Bryan Kennedy; Saralla Nikita Malladi; Panharath Sok; Iman Aganj; Peter Bex; David G Hunter; Eric D Gaier

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 527. doi:

Contrast sensitivity function enhances the prediction of treatment outcome and recurrence in amblyopia via machine learning Open Access

Jing Liu; Chencui Huang; Susan A Cotter; Lily Y.L. Chan; Yizhou Yu; Yu Jia; Qingqing Ye; Lei Feng; Ying Yao; Rengang Jiang; Chutong Xiao; Zixuan Xu; Yijing Zhuang; Zhonglin Lu; Benjamin Thompson; Jinrong Li

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 528. doi:

Impact of amblyopia and strabismus on tests of executive function in adults Open Access

Archayeeta Rakshit; Katrina L Schmid; Debasmita Majhi; Ann L Webber

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 529. doi:

Dichoptic Visual Search in Amblyopia Open Access

Ibrahim Quagraine; Shi Shi; Gokce Busra Cakir; Jordan Murray; Aasef Shaikh; Fatema Firoz Ghasia

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 530. doi:

Eye-body coordination during static balance in children with amblyopia Open Access

Krista R Kelly; Dorsa Mir Norouzi; Norah Nyangau; David Stager; Cynthia L Beauchamp; Prashanthi Giridhar

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 531. doi:

Differences between ON and OFF cortical function in patients with amblyopia Open Access

Vanna Lam Vy Nguyen; Jian Z Jin; Carmen Pons; Jingyun Wang; Jose-Manuel Alonso

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 532. doi:

Treatment outcome in 344 children with amblyopia from a population-based birth-cohort (N=10811) Open Access

Huibert Jan Simonsz; Wilma van den Berg; Anneke Schoonenberg; Jolanda Timmer; Tineke Hoolsema; Marieke Kamphuis; Esmee Bravenboer; Mies Zwart; Linda Boon; Tamara Alteveer; Imke Westra; Elfi Dijkers; Xanne Slot

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 533. doi:

Systemic inflammatory biomarkers are associated with and increased risk of age-related macular degeneration but a decreased risk of cataract in people with AIDS Open Access

Douglas A Jabs; Michael F Schneider; Jeong W Pak; Peter Hunt

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 534. doi:

A higher dietary inflammatory index is associated with increased risk of age-related eye diseases Open Access

Joëlle Vergroesen; Eric F. Thee; Tosca O.E. de Crom; Jessica Christina Kiefte-de Jong; Trudy Voortman; Caroline C W Klaver; Wishal Ramdas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 535. doi:

Shorter Leukocyte Telomere Length Associated with Increased Risk of Age-related Macular Degeneration in Women: Findings from United Kingdom Biobank Open Access

Cancan Xue; Marco Yu; Miao Li Chee; Charumathi Sabanayagam; Ching-Yu Cheng; Yih Chung Tham

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 536. doi:

The role of metformin in reducing risk for AMD in Veterans Open Access

Neal S Peachey; Christopher W Halladay; Bryan R Gorman; Sudha K Iyengar; Wen-Chih Wu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 537. doi:

Association of retinal bioparameters and periodontal disease: a cross-sectional analysis from the UK Biobank cohort Open Access

Siddharth Nath; Siegfried Wagner; Praveen J Patel; Mario Cortina Borja; Dominic Williamson; Robbert Struyven; David Romero-Bascones; Anthony Khawaja; Axel Petzold; Konstantinos Balaskas; Iain Chapple; Thomas Dietrich; Jugnoo Rahi; Alastair K Denniston; Pearse Keane

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 538. doi:

Onset and progression of diabetic retinopathy within eight years in type 2 diabetes in the Danish Registry of Diabetic Retinopathy Open Access

Jakob Grauslund; Frederik Pedersen; Nis Andersen; Jens Andresen; Toke Bek; Sebastian Dinesen; Javad Hajari; Steffen Heegaard; Kurt Højlund; Caroline Laugesen; Ryo Kawasaki; Soren Moller; Katja Schielke; Anne Suhr Thykjær; Lonny Stokholm

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 539. doi:

Prevalence, concordance, and heritability of posterior vitreous detachment (PVD) in a twin population Open Access

Dominic Shou Huang Wong; Zakariya Jarrar; Abdus Samad Ansari; Katie Williams; Pirro G Hysi; Omar Abdul Rahman Mahroo; Christopher J Hammond

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 540. doi:

Glaucoma Suspect Data Improve the Deep Learning based Glaucoma Diagnosis Performance Open Access

ashkan abbasi; Bhavna Josephine Antony; Sowjanya Gowrisankaran; Gadi Wollstein; Joel S Schuman; Hiroshi Ishikawa

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 541. doi:

Patterns of Neuronal and Central Visual Field Loss in Optic Neuritis at Outcome Identified by Machine Learning Open Access

David Szanto; Jui-Kai Wang; Brian Woods; Tobias Elze; Mona K Garvin; Louis R Pasquale; Randy H Kardon; Joseph Branco; Mark J Kupersmith

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 542. doi:

Using 3D Deep Learning for Classification of Multiple Retinal Diseases on Optical Coherence Tomography Images Open Access

Ziqi TANG; Yuhan Zhang; Gabriel YANG; Anran RAN; Simon Szeto; Mary Ho; Victor Chan; Pheng-Ann Heng; Carol Cheung

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 543. doi:

Deep learning-based detection of advanced AMD on retinal OCT from the UK Biobank dataset on behalf of the PINNACLE Consortium Open Access

Oliver Leingang; Hrvoje Bogunovic; Gregor Sebastian Reiter; Arunava Chakravarty; Martin Joseph Menten; Robert Holland; Lars G Fritsche; Hendrik P Scholl; Daniel Rueckert; Sobha Sivaprasad; Andrew J Lotery; Ursula Schmidt-Erfurth

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 544. doi:

Self-supervised machine learning for individual prediction of conversion to neovascular AMD in PINNACLE study Open Access

Arunava Chakravarty; Taha Emre; Oliver Leingang; Sophie Riedl; Julia Mai; Hendrik P Scholl; Sobha Sivaprasad; Lars G Fritsche; Daniel Rueckert; Andrew J Lotery; Ursula Schmidt-Erfurth; Hrvoje Bogunovic

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 545. doi:

Federated Machine Learning in Medical imaging and against Adversarial Attacks: A retrospective multicohort study Open Access

Zhen Ling Teo; Xiaoman Zhang; Ting Fang Tan; Narrendar Ravichandran; Liu Yong; Daniel SW Ting

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 546. doi:

Optical coherence tomography for the prediction of major adverse cardiovascular events in AlzEye Open Access

Mark Chia; Yukun Zhou; Siegfried Wagner; Dominic Williamson; Robbert Struyven; Axel Petzold; Alastair K Denniston; Jugnoo Rahi; Mario Cortina Borja; Pearse Keane

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 547. doi:

Effect of dipeptidyl peptidase-4 inhibitors and sodium-glucose cotransporter-2 inhibitors on retinal complications in type 2 diabetic patients Open Access

chungwoon kim; Joong Hyuk Choi; Jaeeun Yu; Yoo-Ri Chung; Kihwang Lee

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 548. doi:

Effective Duration of Fluocinolone Acetonide (FAc) Implant in the Treatment of Diabetic Macular Edema Open Access

Khushi Saigal; Sophia El Hamichi-Potamkin; Syed Gibran Khurshid

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 549. doi:

The relationship between blood flow velocity and local nonperfusion area in healthy and diabetic retinopathy eyes Open Access

Hisashi Fukuyama; Jessica Moonjely; Daniela Castellanos -Canales; Nicole Louise Louise Decker; Amani A Fawzi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 550. doi:

Real-world data from patients with chronic diabetic macular edema and non-infectious uveitis related edema treated with intravitreal fluocinolone acetonide Open Access

Antonio Bergua; Bettina Hohberger; Melany Roger

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 551. doi:

Diagnostic Accuracy of the Flicker Full Field Electroretinogram to Detect Retinal Dysfunction in Diabetic Retinopathy: Frequency Domain Parameter Correlations Open Access

Sean Monday; Andrew Tirsi; Matthew Emmer; Stephanie Tedford; Anthony Fontanetta; Victor H Gonzalez

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 552. doi:

Assessment of erytrhopoietin as a treatment of Chronic Renal Disease anemia and its influence in Diabetic Retinopathy evolution Open Access

Amanda Sasse; Miguel Amaro; Arthur Nassaralla; Cristina Muccioli; Luiz Henrique Lima; Joao J Nassaralla

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 553. doi:

Baseline Characteristics and Risk of Major Adverse Cardiovascular Events in Responders vs Incomplete Responders to anti-VEGF Therapy for Diabetic Retinopathy or Macular Edema Open Access

Neha S Basti; Kathryn M Bryar; Michael Drakopoulos; Rukhsana Mirza; Dustin D French; Paul J Bryar

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 554. doi:

Biomarker identification by proteomic analysis of vitreous humor and plasma from diabetic retinopathy patients Open Access

Qin Zhang; Angela Banks; Rebecca Stacy; Ning Li; Yesel Kim; Lori Jennings; Nancy Finkel; Joseph Loureiro; Anfan Wu; Amy Chen; Cynthia L Grosskreutz; Qian Huang; Ganesh Prasanna

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 555. doi:

Aflibercept exerts structural protection against diabetic retinopathy-associated inner retinal abnormalities in the mouse STZ model Open Access

Symantas Ragauskas; Tomas Paulauskas; Inesa Lelyte; Donatas Neverauskas; Kernius Mickevicius; Robertas Cesna; Giedrius Kalesnykas; Simon Kaja

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 556. doi:

Response Rate to Anti-Vascular Endothelial Growth Factor Therapy in Diabetic Macular Edema Patients Treated with Systemic Renin-Angiotensin-Aldosterone System Antagonists Open Access

Daniel E. Maidana; Eyad Hamad; Mark C. Perkowski; Andrius Kazlauskas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 557. doi:

The Role of Inflammatory Biomarkers on Diabetic Retinopathy Status in Type 2 Diabetes Open Access

Matias Soifer; Elvira Agron; Fares Siddig; walter ambrosius; James Lovato; Emily Y. Chew

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 558. doi:

How PDGF-A acts against ischemia by hyperoxic condition? Open Access

Kaito Yokota; Hidetsugu Mori; Yuki Hattori; Masatoshi Omi; Haruhiko Yamada; Kanji Takahashi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 559. doi:

Density of retinal circulation is unchanged in hyperglycemic mice in first year of life Open Access

Phillip Braun; Fei Shang; Jesse B Schallek

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 560. doi:

Characterization of the retinal phenotype in the offspring of maternal obesity Open Access

Anna Sergeyevna Usoltseva; Rui Cheng; Jiyang Cai; Jian-Xing Ma; Shaoning Jiang; Yan Chen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 561. doi:

Epac2 deletion prevents retinal neurovascular degeneration in a mouse model of retinal ischemia-reperfusion Open Access

Fan Xia; Seth Edward Buscho; Shuizhen Shi; Erick Palacios; Wenbo Zhang; Hua Liu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 562. doi:

Assessment of Retinal Arterial Leakage at Sites of Vascular Smooth Muscle Cell Loss in Caveolin-1 KO and Aged Mice Open Access

Scott Garrett; Michael H Elliott; Jami Gurley

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 563. doi:

Differential effect of inflammatory mediators on the inner and outer blood-retinal barrier Open Access

Jan Niklas Ness; Martina Tholen; Julia Mitschke; Hansjuergen Agostini; Gunther R Schlunck; Thomas Reinheckel; Martin J. Hug; Felicitas Bucher

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 564. doi:

Triciribine Attenuates Pathological Neovascularization and Vascular Permeability in a Mouse Model of Proliferative Retinopathy Open Access

Shengshuai Shan; Fang Liu; Payaningal R Somanath; S. Priya Narayanan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 565. doi:

Common carotid artery occlusion fosters retinal inflammatory responses in streptozotocin-induced diabetic mice Open Access

Deokho Lee; Yukihiro Miwa; Yohei Tomita; Kazuno Negishi; Toshihide Kurihara

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 566. doi:

The LINC00200/SERPINE-1 axis is a potential molecular framework underlying ROP protection in preeclampsia Open Access

Tanner Nelson; Kinsey Shirer; Blair Wood; Lakshmi Katikaneni; Lara Carroll; Colette Cornia; Christopher Stubben; Camille Fung; Christian Yost; Jessica Comstock; Margaret M DeAngelis; Leah Owen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 567. doi:

Norrin prevents visual loss in diabetic rats Open Access

Alyssa Dreffs; Cheng-mao Lin; Monica Diaz Coranguez; Sarah Sheskey; David A Antonetti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 568. doi:

Synaptic connectivity impairment and neuronal degeneration in the macula of diabetic patients along with the vascular abnormalities Open Access

Henar Albertos-Arranz; Oksana Kutsyr Kolesnyk; Lorena Vidal-Gil; Isabel Ortuño-Lizarán; Xavier Sánchez-Sáez; María José Ruiz-Pastor; Natalia Martínez-Gil; Carla Sánchez-Castillo; Pedro Lax; Nicolas Cuenca

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 569. doi:

Longitudinal Retinal Imaging Analysis in Streptozotocin-Induced Diabetic Mice Reveals Sexual Dimorphism in Phenotype. Open Access

Quinn Rose Caron; Rupesh Singh; Julia C Batoki; Mariya Ali; Bela Anand-Apte

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 570. doi:

VEGF as direct functional regulator of photoreceptors and major contributing factor for reduced retinal function in hypoxic and diabetic retinal disorders Open Access

Yun-Zheng Le; Meili Zhu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 571. doi:

Retinal oxygen metabolism and neuro-vascular coupling in patients with type II diabetes at different stages of diabetic retinopathy Open Access

Nikolaus Hommer; Doreen Schmidl; Martin Kallab; Andreas Schlatter; Kinga Howorka; René Werkmeister; Leopold Schmetterer; Gerhard Garhofer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 572. doi:

Exploring the vasoreparative function of the APC/EPCR pathway in diabetic retinopathy Open Access

Amie Lowry; Elisa Peixoto; Sarah Chambers; Reinhold Medina; Alan Stitt; Judith Lechner

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 573. doi:

Identifying Novel Candidate Compounds to Be Repurposed for Retinopathy of Prematurity via Drug-Gene Association Analysis Open Access

Edward F Xie; Sarah Rodriguez; Bingqing Xie; Mark D'Souza; Reem Gonnah; Dinanath Sulakhe; Dimitra Skondra

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 574. doi:

Short-chain fatty acid signaling in retinopathy of prematurity Open Access

Tommy Bui; Allston Oxenrider; Ronny Amaoo; Pamela M Martin; Menaka Thounaojam; Ravirajsinh Jadeja

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 575. doi:

PERK inhibition suppresses neovascularization and protects neurons during ischemia-induced retinopathy Open Access

Shuizhen Shi; Shuang Zhu; Chun Ding; Fan Xia; Seth E Buscho; Shengguo Li; Massoud Motamedi; Hua Liu; Wenbo Zhang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 577. doi:

Residual Neuropathy Target Esterase activity predicts retinopathy among PNPLA6 disorders Open Access

James Liu; Yi He; Chisom Madu; Lijin Dong; Marina Han; Cara Lwin; Gavin Arno; Anthony Moore; Andrew R Webster; Michel Michaelides; Laryssa Huryn; Bin Guan; Robert B. Hufnagel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 578. doi:

Hepatic HIF Stabilization by Novel Carbonyl Glycine Derivatives Protects Against Oxygen-Induced Retinopathy Open Access

Christie Kay Campla; George Hoppe; Demiana Hanna; Andrew Dale Benos; Vara Prasad Josyula; Shaun Stauffer; Juliana Woda; Jonathan E Sears

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 579. doi:

Metabolic mechanisms in oxygen-induced retinopathy: findings from OIR resistant and susceptible mouse strains Open Access

Charandeep Singh; Russell Goodman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 580. doi:

RUNX2 pathway activation in Alzheimer's disease, age-related macular degeneration, and diabetic retinopathy – a proteome analysis Open Access

Anddre Valdivia; Ye He; Xiaorong Li; Hossein Nazari

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 581. doi:

Retinal vascular calibers are not predictive for long-term progression to proliferative diabetic retinopathy Open Access

Sebastian Dinesen; Lonny Stokholm; Thiusius Rajeeth Savarimuthu; Yousif Subhi; Tunde Peto; Jakob Grauslund

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 582. doi:

Prenatal Supplementation of Lutein and Zeaxanthin are Beneficial against Oxygen-Induced Retinopathy (OIR) in Bco2^-/-Macular Pigment Mice Open Access

Arunkumar Ranganathan; Binxing Li; Emmanuel Kofi Addo; Mary Elizabeth Hartnett; Paul S Bernstein

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 583. doi:

Assessment of peripheral circulating angiogenic cells and inflammatory markers in diabetic retinopathy individuals Open Access

Neha Mahajan; Qianyi Luo; Amir Reza Hajrasouliha; Ashay D Bhatwadekar

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 585. doi:

Bile acid receptor signaling in oxygen oxygen-induced retinopathy Open Access

Menaka Thounaojam; Allston Oxenrider; Vijay C Ganta; Pamela M Martin; Ravirajsinh Jadeja

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 587. doi:

Single-cell transcriptomics drives disease-specific targeted therapy for ischemic retinopathy Open Access

Jose Carlos Rivera; Gael Cagnone; Mei Xi Chen; Sheetal Pundir; Florian Wunnemann; Piet van Vliet; Severine Leclerc; Gregor Andelfinger; Sylvain Chemtob; Jean-Sebastien Joyal

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 588. doi:

A 20-year Retrospective Analysis of Methicillin and Moxifloxacin Susceptibility among Staphylococcus aureus Keratitis Isolates Open Access

Eric G Romanowski; Alex Mammen; Deepinder K. Dhaliwal; Vishal Jhanji; Hazel Q Shanks; Robert M Q Shanks

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 589. doi:

The Bacterial Ocular Surveillance System (BOSS): 2019-2020 report Open Access

Maria Paulina Cabrera-Aguas; Monica Lahra; Stephanie L Watson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 590. doi:

Longitudinal Analysis of In Vitro Antibiotic Resistance Rates among Ocular Staphylococci Collected in the ARMOR Study Open Access

Penny A Asbell; Christine M Sanfilippo; Heleen DeCory

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 591. doi:

Diversity and Frequency of Bacteria and Fusarium Symbiosis Open Access

Darlene Miller; Jorge Maestre; Alexander Jesus Alfonso; Heather Ann Durkee; Guillermo Amescua; Jean-Marie Parel; Eduardo Alfonso; Harry W Flynn, Jr.

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 592. doi:

Characterization of conjunctival microflora and antibiotic sensitivity pattern in patients undergoing cataract surgery Open Access

Aldo Vagge; Diego Ponzin; Chiara Del Noce; Davide Camposampiero; Marcello Santocono; Carlo Traverso; Giuseppe Giannaccare

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 593. doi:

Clinical presentation, management and outcome of post-keratoplasty infectious keratitis: A 7-year study Open Access

Zun Zheng Ong; Lakshmi Suresh; Yasmeen S. J. Hammoudeh; Dalia G. Said; Harminder S Dua; Darren Shu Jeng Ting

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 594. doi:

The performance of Visuprime® in reducing conjunctival bacterial load in patients receiving cataract surgery. Open Access

Alessio Martucci; Andrea Corsi; Alessandro Tiezzi Appolloni

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 595. doi:

Temporal Efficacy and Sterility Testing of Povidone-Iodine from an Open Bottle Open Access

Akil Hinds; Murad Alfaqih; Rachel Hicken; Abrar Chaudhry; Ali Ramadan; Salman Yousuf

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 596. doi:

Correlation of Visual Outcomes in Patients with Acanthamoeba Keratitis Based on Genotypes and Presence of Viral Endosymbionts Open Access

Juan Carlos Navia; Paula A. Sepulveda-Beltran; Alexander Jesus Alfonso; Jorge Maestre; Heather Ann Durkee; Jaime Martinez; Harry W Flynn, Jr.; Eduardo Alfonso; Jean-Marie Parel; Guillermo Amescua; Darlene Miller

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 597. doi:

Herpes zoster ophthalmicus rates in Australia, 2016–2021 Open Access

Sachin Phakey; Anthony John Hall; Lyndell L Lim

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 598. doi:

Increasing Incidence of Ocular Syphilis in Hillsborough County, Florida Open Access

Haider Ghumman; Kimberly Menezes; Nisarg Joshi; Swetangi Bhaleeya

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 599. doi:

In vitro evaluation of antibacterial, antiviral and antifungal activity of MDV-0911 I/D Open Access

Valentina Amico; Melina Cro; Angela Assero; Sebastiano Mangiafico

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 600. doi:

Efficacy of Topical 2% Cyclosporine in Controlling the Inflammation and Improving the Treatment Outcomes in Patients with Acanthamoeba Keratitis. Open Access

Matteo Posarelli; Pedram Hamrah

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 601. doi:

Topical anesthetic gel interferes with antibacterial efficacy of povidone-iodine both in vitro and in vivo Open Access

Cecilly Kelleher; Jacob Im; Linda Kang; Aleksey Mishulin; Sukhvinder Singh; Ashok Kumar

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 602. doi:

Evaluation of feline-herpesvirus-1 for genomic mutations and antiviral resistance in cats treated with antiviral medications Open Access

Melanie A Mironovich; Nikole Ineck; Morgan Marino; Chin-Chi Liu; Ugochi Emelogu; Erinn Mills; Pilar Camacho; Renee Carter; Andrew Lewin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 603. doi:

Host defense peptide inhibits growth and biofilm formation during Streptococcus pneumoniae infection and aids in wound healing in vitro Open Access

Priyasha Mishra; Sanjay Ch; Swati Biswas; Sanhita Roy

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 604. doi:

Lacritin bactericidal tear proteoform 'N-104' binds tear thrombin and synergizes with its GKY20 peptide to efficiently kill pathogenic P. aeruginosa strain PA14 Open Access

Mohammad Sharifian Gh.; Fatemeh Norouzi; Gordon W Laurie

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 605. doi:

Inhibition of Multidrug-Resistant Pseudomonas aeruginosa with Rose Bengal Photodynamic Antimicrobial Therapy: In vitro Open Access

Felipe Echeverri Tribin; Brandon Chou; Katherine Krishna; Heather Ann Durkee; Jorge Maestre; Angel Suarez; Maribel Hernandez; Harry W Flynn, Jr; Guillermo Amescua; Jean-Marie Parel; Darlene Miller

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 606. doi:

Povidone-iodine in-vitro anti-septic efficacy as a function of exposure duration, concentration, preparation, and length of storage Open Access

Christina Ambrosino; Leo L. Shen; Heba Mahjoub; Warda Memon; Sean X. Zhang; Mark P. Breazzano

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 607. doi:

Methylene Blue Photodynamic Antimicrobial Therapy Inhibition Against Common Ocular Isolates In Vitro Open Access

Brandon Chou; Katherine Krishna; Heather Ann Durkee; Felipe Echeverri; James Lai; Guillermo Amescua; Darlene Miller; Jean-Marie Parel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 608. doi:

In vitro Inhibition of Aspergillus and Fusarium Species with Erythrosin B, Eosin Y, and Rose Bengal Photodynamic Antimicrobial Therapy Open Access

Katherine Krishna; Brandon Chou; Heather Ann Durkee; Felipe Echeverri; James Lai; Guillermo Amescua; Darlene Miller; Jean-Marie Parel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 609. doi:

Genotypic Differences Among Bacillus cereus Ocular and Gastrointestinal Isolates and the Relationship to Endophthalmitis Pathogenesis Open Access

Austin Layne LaGrow; Phillip S Coburn; Frederick Christian Miller; Md Huzzatul Mursalin; Aaron Parrott; Anna Gregory; Daniel Astley; Michelle C Callegan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 610. doi:

Development and Clinical Validation of A Novel CRISPR-Based Diagnostic Platform for the Diagnosis of Ocular Fungal Infections Open Access

Siddharth Narendran; Hanith Raj Deivarajan; Prajna Lalitha; Venkatesh Prajna

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 611. doi:

Development of a rapid viability RT-PCR assay for detection of infectious SARS-CoV-2 Open Access

Judith Veugen; Tom Schoenmakers; Inge van Loo; Mathie Leers; Rudy Nuijts; Paul Savelkoul; Mor Dickman; Petra Wolffs

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 612. doi:

Low-volume direct strip multiplex PCR of intraocular fluid in uveitis Open Access

Joyce H Yamamoto; Eduardo Ferracioli Oda; Tatiana Tanaka; Michele Soares Gomes Gouvea; Joâo Renato Rebello Pinho; Verônica Coelho; Paulo J.M. Bispo; Carlos Eduardo Hirata

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 613. doi:

Characterization and Correlation of Staphylococcus aureus Virulence Factors ARG and Spa Profiles with Site Specific Ocular Infections Open Access

Heather Ann Durkee; Jorge Maestre; Alexander Jesus Alfonso; Harry W Flynn, Jr; Guillermo Amescua; Jean-Marie Parel; Darlene Miller

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 614. doi:

Pathogen identification in endophthalmitis: FRES (Freiburg Endophthalmitis Set) versus standard procedure; a retrospective multicenter comparative study Open Access

Thomas Ness; Karl Ulrich Bartz-Schmidt; Florian Gekeler; Albrecht Bartz-Schmidt

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 615. doi:

Prevalence of posterior polymorphous corneal dystrophy type 3 in the Czech population Open Access

Petra Liskova; Jana Jedlickova; Alice E Davidson; Nathaniel J. Hafford-Tear; Lubica Dudakova; Pavlina Skalicka

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 616. doi:

Histatin-1 Decreases Corneal Endothelial Cell Death in Ex-Vivo Human Corneas Open Access

Onkar Sawant; Jessica Ludwig; Madison Castellanos; Dixie-Lee Shurland; Matt Chang; Ricardo Cruz; Patrick Hughes; James A Burke; Rhett M Schiffman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 617. doi:

The engineered fibroblast growth factor TTHX1114 mediates enrichment of proliferative and wound healing pathways in wounded human corneal endothelium Open Access

Grace Duffey; Lindsey Myers; Tyler Todd; Jessica Weant; David Eveleth

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 618. doi:

The Relationship between Triplet Repeats in the TCF4 Gene and Progression of Fuchs Endothelial Corneal Dystrophy over One Year Open Access

Oliver Dorado Cortez; Emmanuel Crouzet; Marie Caroline Trone; Philippe Gain; Zhiguo HE; Hanielle Vaitinadapoule; Marielle Mentek; Frédéric Mascarelli; Sylvain POINARD; Go Nishiuchi; Mari Yasunaga; Noriko Koizumi; Naoki Okumura; Gilles Thuret

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 619. doi:

MG53 Protects Against Oxidative Stress In Corneal Endothelial Cells Open Access

Luxi Zhang; Tania Foster; Ashley Mauer; Hua Zhu; Heather L Chandler

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 620. doi:

TTHX1114 Protects Primary Rabbit Corneal Endothelial Cells from Oxidative Stress Open Access

Anna Stuhlfire; Lindsey Myers; Grace Duffey; Jessica Weant; David Eveleth

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 621. doi:

A Comparison of Corneal Endothelial Cells between Hispanics and Non-Hispanics Open Access

Saxon Hancock; Luis Edmundo Vasquez; Christian Lee; Rafael Heinz Montoya; Ahmad Kheirkhah

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 622. doi:

Body Mass Index and Fuchs’ Endothelial Corneal Dystrophy (FECD) Open Access

Yihua Yue; Sangita P Patel; Jing Nie; Chris A. Andrews; Jean Wactawski-Wende; Aladdin Shadyab; Robert Wallace; Amy E Millen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 623. doi:

The use of rho-associated kinase inhibitors for corneal endothelial cell replacement therapeutics Open Access

Gary S L Peh; Dawn Neo; Belinda Tan; Xiao-Yu Ng; Hon Shing Ong; Jodhbir S Mehta

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 624. doi:

Feasibility of a Corneal Endothelial Cell Therapy using two in vitro corneal models. Open Access

Sergio Alonso-Alonso; Natalia Vázquez; Manuel Chacon; Alvaro Meana; Jesus Merayo-Lloves; Mairobi Persinal-Medina

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 625. doi:

Role of SLC4A11 and its Third Extracellular Loop in the Adhesion of Corneal Endothelial Cells to Descemet Membrane Open Access

Pascale Charpentier; Kim Santerre; Stéphanie Proulx

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 626. doi:

Early predictors of successful corneal endothelial cell injection therapy Open Access

Jodhbir S Mehta; Evan Wong; Hon Shing Ong; Hla Myint Htoon; Gary S L Peh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 627. doi:

Combined stressors (UV-A light+estrogen) aggravate FECD characteristics in G2/M arrested corneal endothelial cells (CEnCs) and induces secretion of senescent associated secretory phenotyp... Open Access

Mohit Nishitkumar Parekh; Raymond Wong; Ula V Jurkunas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 628. doi:

Human corneal endothelial cells (HCECs) in-vitro cultivation from donor corneas remnants after penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK) Open Access

Jose Juan Perez-Trujillo; Fernando Morales-Wong; Jesús Mohamed-Hamsho; Roberto Montes-de-Oca-Luna; Karim Mohamed-Noriega

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 629. doi:

The effect of ultraviolet A on TRPV1 and 4 activations on corneal endothelium Open Access

Jungkyu (Jay) Kim; Minju Kim

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 630. doi:

Factors Affecting Recovery Following Descemet Stripping Only (DSO) with TTHX1114 Open Access

Thomas Tremblay; David Eveleth

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 631. doi:

Corneal Transplant in patients with uveitis and Fuchs Endothelial Dystrophy CASE Series Open Access

Diana Morvey; Andrew Philip; Stephen Anesi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 632. doi:

Combined stressors (UV-A and cigarette smoke) exacerbate pro-FECD phenotypes in G2/M arrested corneal endothelial cells Open Access

Sean Tobin Bannon; Mohit Nishitkumar Parekh; Raymond Wong; Ula V Jurkunas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 633. doi:

Long-term outcomes of DMEK grafts from diabetic donors Open Access

Andrea Bordewyk; Alex Bauer; Jessica Shichi Chen; Michael Straiko; Mark Terry

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 634. doi:

Treatment with Neuropeptide alpha-Melanocyte Stimulating Hormone Suppresses Progression of Fuchs Dystrophy in a UV-induced Mouse Model Open Access

Francesca Kahale; Neha Deshpande; Hamid Alemi; Amirreza Naderi; Shudan Wang; Tomas Blanco; Thomas H Dohlman; Jia Yin; Ula V Jurkunas; Reza Dana

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 635. doi:

Effect of Metformin on RNA Foci and MBNL1 Mis-Splicing in Primary Fuchs Endothelial Corneal Dystrophy (FECD) Cells Open Access

Tommy A Rinkoski; Keith H Baratz; Eric D Wieben; Michael P Fautsch

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 636. doi:

Disease progression using multimodal corneal imaging in an early-onset murine model of FECD Open Access

Nayeli Echeverria; Sangwan Park; Jaeho Shim; Michelle Ferneding; Laura J Young; Jessica Skeie; Mark A Greiner; Sara M Thomasy; Brian Leonard

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 637. doi:

Therapeutic Potency of Induced Pluripotent Stem Cell-Derived Corneal Endothelial-Like Cells for Corneal Endothelial Dysfunction Open Access

Eun-Ah Ye; Changmin Kim; Jae Yong Kim; Hungwon Tchah; Eunju Kang; Hun Lee

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 638. doi:

Printing collagen IV membrane for bioengineering human corneal endothelium Open Access

Jingjing You; Morgan Overmass; Li Wen; Sheng Hua; Constantinos Petsoglou; Gerard Sutton

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 639. doi:

RNA Sequencing Analysis of Corneal Endothelial Cells Derived from Fuchs Endothelial Corneal Dystrophy Patients with and without Trinucleotide Repeat Expansion in TCF4 Open Access

Yoshiaki Toyokawa; Naoki Okumura; Tatsuya Nakagawa; Ayana Tateishi; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E. Kruse; Yuichi Tokuda; Masakazu Nakano; Noriko Koizumi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 640. doi:

Impact of Substrate Stiffness on Human Corneal Endothelial Cells Open Access

Samantha Sasseville; Stéphanie Proulx

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 641. doi:

Lifestyle risk factors across Fuchs' endothelial corneal dystrophy severity Open Access

Judith-Lisa Lieberum; Daniel Zander; Thomas Reinhard; Katrin Wacker

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 642. doi:

Nicotinamide mononucleotide prevents iris atrophy-associated corneal endothelial cell loss Open Access

Takefumi Yamaguchi; hirotsugu kasamatsu; Rintaro Ogino; Yukari Yagi-Yaguchi; Reona Kimoto; Kazunari Higa; Jun Shimazaki

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 643. doi:

The senescent characteristics of UV-A exposed human corneal endothelial cells. Open Access

Kohsaku Numa; Koji Kitazawa; Pierre-Yves Desprez; Judith Campisi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 644. doi:

Measures of estrogen exposure in Fuchs endothelial corneal dystrophy (FECD) Open Access

Redion B Petrela; Chandra Divyash Chhetri; Ahmad Najafi; Amy E Millen; Sangita P Patel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 645. doi:

Endothelial cells migration after Descemet membrane fracture and detachment, secondary to forceps trauma during labor Open Access

Manuel Ramirez Fernandez; Emmanuel Cabrera-Martinez; Alejandro Toledo; Itzel Aguilar-Valdez; Emmanuel Romero; Guillermo Dewit-Carter

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 646. doi:

Corneal edema in inducible Slc4a11 knock out is mediated by mitochondrial oxidative stress and Src Kinase activation Open Access

Diego G. Ogando; Edward Kim; Shimin Li; Joseph A Bonanno

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 647. doi:

A Feasibility of Computational Drug Screening for Fuchs Endothelial Corneal Dystrophy Open Access

Itsuki Oka; Naoki Okumura; Tatsuya Nakagawa; Kota Imai; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E. Kruse; Noriko Koizumi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 648. doi:

Identification of Sex-Biased Genes in the Human Corneal Endothelial Cells by using RNA Sequencing Analysis Open Access

Soichiro Inagaki; Naoki Okumura; Tatsuya Nakagawa; Ayana Tateishi; Yuya Komori; Naoya Hanada; Yuichi Tokuda; Masakazu Nakano; Noriko Koizumi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 649. doi:

Estrogens preserve corneal thickness in Slc4a11^-/- mouse model of Congenital Hereditary Endothelial Dystrophy (CHED) Open Access

Wenlin Zhang; Eduardo Araujo; Saloni Gupta; Kavya Jatavallabhula; Arthur P. Arnold; Anthony Aldave

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 650. doi:

Utility of a model to predict endothelial cell density of donor corneas to determine suitability for transplantation: a decision curve analysis. Open Access

Stephanie Desiree Grabitz; Julia Bing Bu; Franziska Schön; Melissa Apel; Tobias Pusch; Adrian Gericke; Alicia Poplawski; Norbert Pfeiffer; Joanna Wasielica-Poslednik

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 651. doi:

Effects of 17-β Estradiol on Mitochondrial Morphology and Oxidative DNA damage in Human Corneal Endothelial Cells (HCEnCs) under Different O₂ Conditions Open Access

Seoyoung Han; Varinda Nayyar; Sangita P Patel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 652. doi:

Generation and RNA Sequencing Analysis of Potential Mouse Model for Fuchs Endothelial Corneal Dystrophy Harboring CTG Trinucleotide Intronic Repeat Expansion in Tcf4 Open Access

Mizuki Ueda; Naoki Okumura; Tatsuya Nakagawa; Yuki Oyama; Satoshi Chiba; Ayana Tateishi; Koki Amano; Ayaka Izumi; Masahito Ikawa; Noriko Koizumi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 653. doi:

Feasibility of injection of cryopreserved cultured human corneal endothelial cells for the treatment of corneal endothelial decompensation by using a rabbit model Open Access

Riko Hadano; Naoki Okumura; Kayoko Yamaguchi; Shuhei Kitayama; Reo Shibazaki; Kanta Ueda; Ayaka Izumi; Yasushi Matsuoka; Noriko Koizumi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 654. doi:

Head Trauma Effect on Corneal Endothelial Cell Density in Eye Bank Donors Open Access

Jessinta Oseni; Jenna Tauber; Gabriel Rand; Jee Young Moon; Patrick Gore; Tina Livesay; Roy S Chuck

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 655. doi:

Fuchs Endothelial Corneal Dystrophy Involves Decreased Expression of Genes for Fe-S Cluster Synthesis Open Access

Emma M. Hartness; Hanna Shevalye; Jessica Marie Skeie; Greg Schmidt; Mark A Greiner

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 656. doi:

Differential effects of ROCK inhibitors ripasudil and netarsudil on corneal endothelial and epithelial cells Open Access

Friedrich E. Kruse; Andreas Giessl; Matthias Zenkel; Theofilos Tourtas; Ursula Schlötzer-Schrehardt

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 657. doi:

Association between clinical phenotypes and TCF4 repeat expansion in Fuchs endothelial corneal dystrophy Open Access

Sayo Maeno; Yoshinori Oie; Ryota Koto; Nozomi Nishida; Arisa Yamashita; Michika Yoshioka; Masahito Yoshihara; Ryo Kawasaki; Motokazu Tsujikawa; Kohji Nishida

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 658. doi:

The effect of CHED- and FECD4-associated SLC4A11 mutations on the subcellular localization of SLC4A11 isoforms 2 and 3 Open Access

Doug Chung; Wenlin Zhang; Angela Chen; Charlene Choo; Dominic Williams; Anthony Aldave

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 659. doi:

Diabetes-related Hyperglycemia Affects Protein Expression and Glycation Events in the Extracellular Matrix of Corneal Endothelial Cells Open Access

Kenten Kingsbury; Jessica M. Skeie; Tim Eggleston; Hanna Shevalye; Greg Schmidt; Esther Baker; Mark A Greiner

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 660. doi:

Observation of primary cilia movement in corneal endothelial cells on the glass rod Open Access

Hidetoshi Tanioka; Hideto Deguchi; Shigeru Kinoshita; Chie Sotozono

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 661. doi:

Corneal Endothelial Severity Scoring System (CESSS) for Fuchs Endothelial Dystrophy (FED) by Specular Microscopy and possible Corneal Zones to Calculate Endothelial Cell Density (ECD) Open Access

Fernando Cesar Abib

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 662. doi:

Expression of Endothelial-Mesenchymal Transition-Related Proteins in Fuchs Endothelial Corneal Dystrophy Cells ex vivo and in vitro. Open Access

Ange Tchatchouang; Sébastien Méthot; Anas Abu Dieh; Isabelle Brunette; Patrick J Rochette; Stéphanie Proulx

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 663. doi:

Associations of Fuchs endothelial corneal dystrophy with systemic comorbidities, lifestyle, and nutrition Open Access

Aaron Richard Kaufman; Myriam Böhm; Francesca Kahale; Pia Leon; Ula V Jurkunas

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 664. doi:

The Effect of Decreased SLC4A11 Expression on Lactate Efflux in Corneal Endothelial Cells Open Access

Shimin Li; Diego G. Ogando; Joseph A Bonanno

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 665. doi:

Lifetime Incidence of Corneal Hydrops in Keratoconic Eyes Post Corneal Collagen Crosslinking versus Contact Lens Management Open Access

Clever Nguyen; Deniz Siso; Nguyen Truong; Jeremy Kudrna; Gargi Vora

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 666. doi:

Correlations of Corneal Endothelial Morphology with Anterior Segment Parameters in healthy adults Open Access

Evangelia Chalkiadaki; Konstantinos Tsiripidis; Panos Gartaganis; Anastasia Tsiogka; Ilias Georgalas; Efthymios Karmiris

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 667. doi:

Age-associated Histopathology in Human and Mouse Lacrimal Glands Open Access

Frederick Fraunfelder; Robert Fantus; Jeffrey Stetler; Anna Romine; Lixing W Reneker

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 668. doi:

Biophysical behaviors of meibum from mice with meibomian gland dysfunction Open Access

Erin Hisey; Tanner J Finney; Tonya L Kuhl; Daniel M Albert; Charles A O'Neill; Thomas R Gadek; Jennifer Y Li; Sangwan Park; Christopher J Murphy; Sara M Thomasy; Atul N Parikh; Brian Leonard

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 669. doi:

LRRC26 is a Potential Therapeutic Target for Dry Eye Disease Open Access

Hua Yang; Ming Yuan; Ying Hu; Jingtai Cao; Ralph J Hazlewood; Botir T Sagdullaev

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 670. doi:

Inflammation mediated by TNFα or IFNγ upregulates gene expression of major complement proteins by conjunctival epithelial cells Open Access

Jillian F. Ziemanski; Alexander J Szalai

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 671. doi:

New eyedrops formulation based on desonide and xanthan gum: preclinical studies. Open Access

Cristina Zappulla; Luca Rosario La Rosa; Giuseppe De Pasquale; Manuela Santonocito; Donato Spina; Ilenia Abbate; Maria Cristina Curatolo; MARIA GRAZIA MAZZONE; Santa Viola

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 672. doi:

Investigation of a Set of Dysregulated Tear Proteins of Sjögren’s Syndrome Patients Using In Vitro Models Uncovers New Insights and Potential Candidate Biomarkers Open Access

Murat Akkurt Arslan; Françoise Brignole-Baudouin; Ghislaine Rabut; Solenne Chardonnet; Cédric Pionneau; Annabelle Reaux Le Goazigo; Christophe Baudouin; Karima Kessal

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 673. doi:

A Latent Profile Analysis of Tear Cytokine Levels for Their Association with Severity of Dry Eye Disease in the Dry Eye Assessment and Management (DREAM) Study Open Access

Yineng Chen; Penny A Asbell; Gui-Shuang Ying

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 674. doi:

The Cross-talk between Androgen and Estrogen Signaling in Meibomian Glands Open Access

Lixing W Reneker; Dennis B Lubahn; Andrew J W Huang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 676. doi:

Therapeutic Effect of Topical Placental Extracts Eyedrops in Experimental Dry Eye Open Access

Jayoung Moon; Hui Jin; Hee su Yoon; Ji Suk Choi; Jonghwa Kim; HYEON JEONG YOON; Kyung Chul Yoon

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 677. doi:

Atg5-mediated lipophagy induces lipid droplets catabolism and promotes ferroptosis in corneal epithelial cells in dry eye disease Open Access

Xin Zuo; Bowen Wang; Jin Yuan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 678. doi:

Genipin crosslinking of porcine decellularized lacrimal gland bioink Open Access

Sema Kaya; Katharina Wiebe Ben-Zakour; Luis Grumm; Michael Hacker; Gerd Geerling; Joana Witt

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 679. doi:

1,5-Dicaffeoylquinic acid from Pseudognaphalium affine ameliorates dry eye disease via suppression of inflammation and protection of the ocular surface. Open Access

Joo Youn Oh; Jin Suk Ryu; Chang Ho Yoon; Hyun-Jae Jang; Jung Hwa Ko; Kyung-Seop Ahn; Sei-Ryang Oh; Jang-Hee Oh; Jin Ho Jung

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 680. doi:

Desiccation induced changes in cell number, gene expression profiles and transcriptional trajectories in conjunctival myeloid cells Open Access

Stephen C Pflugfelder; Jahan Alam; Cintia S. De Paiva; De-Quan Li; Ghasem Yasdanpanah; Kaitlyn Xiong; Zhen Zhong

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 681. doi:

TRPA1 nociceptor: a regulator of trigeminal neurogenic inflammation Open Access

Tiffany Migeon; Tristan Hourcade; Christophe Baudouin; Annabelle Reaux Le Goazigo; Stéphane melik-parsadaniantz

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 682. doi:

Limbal stem cell dysfunction induced by severe dry eye via activation of p38 MAPK signaling pathway Open Access

Wei Li; Sijie Lin; shangkun ou; Minqing Cai; Zuguo Liu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 683. doi:

A new method for post-blink tear film leveling analysis in healthy and dry eyes during spontaneous blinking Open Access

Dorota Helena Szczesna-Iskander; Dominika Sulot

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 684. doi:

Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye Open Access

Amalia Enriquez-De-Salamanca; Alfredo Domínguez-López; Marta Blanco-Vázquez; Andres Angel Calderon-Garcia; Carmen Garcia-Vazquez; María J. González-García; Margarita Calonge

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 685. doi:

Use of tear secretion and tear film to screen potential dry eyes in a cynomolgus monkey population Open Access

Lichuan Yang; Jinhua Zhu; Guanzhong Wang; XiaoYing Liang; Fute Tao; Xiaohui Yang; Ying Shen; Jinqiu Liao; Xingbo Zhou; Yaxiong Li; Hui Zhang; TianYu Dong

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 686. doi:

Comparison of human meibomian glands with other free and hair-associated sebaceous glands in terms of biomarker expression and lipid composition Open Access

Friedrich P Paulsen; Fabian Garreis; Igor A Butovich; Michael Scholz; Samir Jabari; Jana Dietrich; Yuqiuhe Liu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 687. doi:

Clinical Proteomics Unravel Novel Protective Mechanisms of Thealoz® Duo Eye Drops in Evaporative Dry Eye Patients Open Access

Natarajan Perumal; Eunjin Jeong; Sarah Runde; Caroline Manicam; Norbert Pfeiffer; Franz Grus

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 688. doi:

Comparison of a Novel Janus Kinase Inhibitor to Available Treatments in a Murine Model of Meibomian Gland Dysfunction Open Access

Alan McDougal; Robert Brown; Maria Ina; Meredith Weksler; Heeren Gordhan; Stuart Williams; David A. Ellis

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 689. doi:

A novel adiponectin receptor agonist for the treatment of dry eye disease that may address both corneal signs and subjective symptoms Open Access

Bongcheol Kim; Jaekwang Lee; Dong Sik Kim; Daehwan Kim; Soojin Kim

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 690. doi:

Cellular senescence promotes meibomian gland dysfunction (MGD) in a chronic graft-vs-host disease (cGVHD) mouse model Open Access

Shinri Sato; Yoko Ogawa; Eisuke Shimizu; Masatoshi Hirayama; Shigeto Shimmura; Kazuno Negishi; Kazuo Tsubota

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 691. doi:

Rabbit model of aqueous deficiency dry eye secondary to periglandular cicatrizing conjunctivitis Open Access

Swati Singh; Saumya Srivastav; Kiran bokara; Vivek Singh; Sayan Basu; Friedrich P Paulsen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 692. doi:

Hedgehog signaling and lipid synthesis during Meibomian gland development and homeostasis in mouse and human Open Access

Carlo Iomini; Céline Portal; Varuni Rastogi; Yvonne Lin; Amber Wilkerson; Igor A Butovich

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 693. doi:

Blink® Triple Care Improves Tear Film Stability in an MGD Rabbit Model. Open Access

Annabelle C Gallois-Bernos; Caroline Blackie; Ross Franklin; Yongcheng Li; Lichun Zhong; Mingqi Bai

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 694. doi:

Evidence for lipid dysregulation associated with inflammation in lacrimal glands from aged female C57BL/6J mice Open Access

Minchang Choi; Cindy Toscano; Maria Edman; Sarah F Hamm-Alvarez; Cintia S. De Paiva

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 695. doi:

Trigeminal ganglion neural activity is altered in a novel, chronic mouse model of dry eye disease Open Access

Cassandra Brand; Miranda Mathieson; James King; Alan Lomax; Jacob Rullo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 696. doi:

Probiotic Limosilactobacillus reuteri DSM 17938 suppresses corneal barrier dysfunction and conjunctival goblet cell reduction in mice subjected to desiccating stress Open Access

Laura Schaefer; Stephen C Pflugfelder; Robert Britton; Cintia S. De Paiva

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 697. doi:

Evaluation of the therapeutic efficacy of DA-6034(AJU-S56/GLH8NDE) in a dry eye mouse model Open Access

Jun Sang Park; Jae Wook Yang; Chae Eun Kim; Eunjung Kim

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 698. doi:

Novel YP-P10 Peptide reduces corneal damage in a mouse dry eye model compared with Lifitegrast, Cyclosporine, Diquafosol sodium and Hyaluronic acid. Open Access

Laxmikant Gharat; Larry Park; Kyungho Park; Hyun Woo Park; Gary D Novack

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 699. doi:

Effect of irradiation on macrophages and its implication for ocular GVHD Open Access

Judy Weng; Alyanna Corpuz; Ajay Sharma

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 700. doi:

Water Extracts of A Specific Dendrobium for Protection against Corneal and Lacrimal Injuries Caused by UVB-Induced Photokeratitis Open Access

Tsung-Han Lu; Chia-Yun Hsu; Shih-Yun Wei; Meng-Tien Hsieh; Han-Hsin Chang; Chi-Luan Wen; David Pei-Cheng Lin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 701. doi:

Mitigation of Dry Eye Symptoms in A Mouse Photokeratitis Model by Factors Derived from Amniotic Fluid Stem Cells Open Access

Shih-Yun Wei; Tsung-Han Lu; Chia-Yun Hsu; Meng-Tien Hsieh; Han-Hsin Chang; Tzu-Hao Huang; Shiaw-Min Hwang; David Pei-Cheng Lin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 702. doi:

Detection of the glycoprotein FCGBP (IgG Fc binding protein) at the ocular surface Open Access

Lars Bräuer; Thomas Wille; Martin Schicht; Fabian Garreis; Friedrich P Paulsen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 703. doi:

Low-density crosslinked hyaluronic acid soft hydrogel for the treatment of dry eye disease Open Access

Yu Yu; Derek Wai Yee Chow; Laurence Chi Ming Lau; Zhexun Sun; Hongge Wang; Ying Chau

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 704. doi:

Artificial intelligence for tear film break-up time quantification: A dual-task siamese network approach Open Access

Fatima-Zahra EL BARCHE; Anas-Alexis Benyoussef; Mostafa EL HABIB DAHO; Corentin LE CAMUS; François CORTEVAL; Béatrice Cochener; Mathieu Lamard

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 705. doi:

New perspectives for the treatment of Dry Eye Disease secondary to Sjögren’s syndrome: cell therapy with injection of mesenchymal stem cells in the lacrimal glands - an experimental study Open Access

Thainá Vilella Rodrigues Maria; Priscila Cardoso Cristovam; Lucimeire Nova de Carvalho; Vitória Regina da Silva Gomes; Diogo Ponciano dos Santos; Mayara Rosa Dias; Leonardo Queiroz Rodrigues de Souza; Taís Hitomi Wakamatsu; José Alvaro Pereira Gomes

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 706. doi:

Assessment of activity of antimicrobial fabric used for eye bag and masks Open Access

Debarun Dutta; SRIKANTH DUMPATI

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 707. doi:

The association between childhood trauma and dry eye in adult life: new insights in the causality between mental health and dry eye Open Access

Mathias Kaurstad Morthen; Morten Schjerven Magno; Tor Paaske Utheim; Christopher J Hammond; Jelle Vehof

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 708. doi:

Plasmacytoid dendritic cells are the major leukocyte sources of neurotrophins in corneas with dry eye disease and during steady state Open Access

Jun Mo; Brendan Kenyon; Helen He; Deshea L Harris; Pedram Hamrah

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 709. doi:

SPR-397, 0.25% Ophthalmic Solution May Break the Inflammatory Cycle of Dry Eye Disease Open Access

Christopher Crean; Angela Dixon; Wendy Cousin; Ransi Somaratne

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 710. doi:

Neurosensory alterations in different mouse models of dry eye disease Open Access

Marina Zieger; Flavia Leao Barbosa; Brendan Kenyon; Jun Mo; Deshea L Harris; Pedram Hamrah

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 711. doi:

Investigation of a novel rabbit nonpolar lipid for the treatment of evaporative dry eye disease in a murine model Open Access

Brian Leonard; Erin Hisey; Sangwan Park; Daniel M Albert; Charles O’Neill; Christopher J Murphy; Thomas R Gadek; Jennifer Y Li; Sara M Thomasy; Atul N Parikh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 712. doi:

Evaluating dry eye model in mice using different methods Open Access

Geeta K Vemuganti; Induvahi Veernala; Vivek Singh; Javed Ali Mohammad

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 713. doi:

Early responses of human corneal and conjunctival epithelial cells to hyperosmotic stress Open Access

Guoting Qin; Shara Duong; Chengzhi Cai

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 714. doi:

Repairing the Corneal Nerve Bed using Collagen Mimetic Peptides Open Access

Lauren K Wareham; Joseph Holden; Olivia Bossardet; Robert O. Baratta, MD; Brian J Del Buono; Eric Schlumpf; George W Ousler; David J Calkins

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 716. doi:

Aprepitant ameliorates epithelial disease and reduces pain in a murine dry eye model Open Access

Giulio Ferrari; Ibrahim Halil Demirsoy; Filippo Bonelli; Romina Mayra Lasagni Vitar; Philippe Fonteyne

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 717. doi:

Neurokinin 1 Receptor Antagonist: a Novel Analgesic for Pain following Corneal Alkali Burn Open Access

Hideaki Someya; Amirreza Naderi; Aytan Musayeva; Shudan Wang; Francesca Kahale; Akitomo Narimatsu; Yihe Chen; Reza Dana

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 718. doi:

Efficacy of Extranasal Neurostimulation for Patients with Neuropathic Corneal Pain Open Access

Onur Olcucu; Anya de Leeuw; Pedram Hamrah

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 719. doi:

Transient receptor potential vanilloid 1-deficiency protects from immune-mediated corneal nerve damage in dry eye Open Access

Manuela Pizzano; Alexia Vereertbrugghen; Florencia Sabbione; Irene Angelica Keitelman; Carolina Maiumi Shiromizu; Douglas Vera; Federico Fuentes; Mirta Nilda Giordano; Analía Trevani; Jeremias Gaston Galletti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 720. doi:

Role of Vitamin Abnormalities as Possible Underlying Etiology in Patients with Neuropathic Corneal Pain Open Access

Chloe S Bogen; Stephanie Cox; Pedram Hamrah

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 721. doi:

Pergolide is comparable to nerve growth factor in recovery after alkali trauma in mouse corneas Open Access

Xiaohui Zhang; Kieley Trempy; Kaitlyn Hunter; Baila Shakaib; Lintao Li; Cornelia Siegl; Bonnie Archer; Sandeep Kumar; Glenwood G Gum; Vatsala Naageshwaran; Balamurali K Ambati

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 722. doi:

Systemic niicergoline, concomitant bandage contact lens and topical autologous serum for severe neurotrophic keratitis Open Access

Alejandro Navas; Eduardo J Polania-Baroin; Arturo J Ramirez-Miranda; Enrique O Graue-Hernandez

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 723. doi:

Changes in Corneal Sensitivity Measured With a Novel Noncontact Esthesiometer in Glaucoma Patients Open Access

Marta Villalba; Marcela Huertas-Bello; Swarup Sai Swaminathan; Alfonso L. Sabater

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 724. doi:

Activation of neurons and satellite glial cells in the trigeminal ganglion causes hypersensitivity and hyperalgesia in dry eye rat model Open Access

Yuto Tei; Yoshinori Mikami; Taichiro Tomida; Daisuke Ohshima; Katsuhide Yamasaki; Ryuji Hisamura; Yuichi Hori; Satomi Adachi-Akahane

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 725. doi:

Outcome of a Multidisciplinary Approach to Treating Chronic Ocular Pain Open Access

Caprice Marie Trifiro; Lara Asroui; Mary Jean Benedetti; Daniel Rotroff; Rony R Sayegh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 726. doi:

Innovative 0.3% Nepafenac Preservative-free Eye Drops Solution Open Access

Fabiola Spitaleri; Danilo Aleo; Maria Grazia Saita; Barbara Melilli; Melina Cro; Sebastiano Mangiafico

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 727. doi:

Safety and Tolerability Study of Suprachoroidal Injection CLS-AX in Neovascular AMD Patients with Persistent Activity Following Anti-VEGF Therapy (OASIS, NCT04626128; Extension Study NCT ... Open Access

Dennis M Marcus; Allen Hu; Mark Barakat; David M Brown; Rahul N Khurana; Joel Pearlman; Charles Clifton Wykoff; Thomas A Ciulla

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 728. doi:

A new eye drop delivery device that resolves patient’s ocular instillation issues Open Access

Pierre Roy; Philippe Daull

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 729. doi:

Ceria-coated melanin nanoparticles protected a blue light-induced retinal damage in Nrf2-deficient mouse model Open Access

Yongsu Kwon; Min Zheng; Zongchao Han

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 730. doi:

More than just an adjuvant: Inhibition of neovascularization via DNA motifs Open Access

Jose Hurst; Julia Alber; Agnes Fietz; Peter Heiduschka; Sven Schnichels

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 731. doi:

Pooled safety analysis of a single intravitreal injection of JNJ-1887 (gene therapy, AAVCAGsCD59) in patients with age-related macular degeneration (AMD) Open Access

Eleonora M Lad; Daniel L Chao; Anthony Pepio; Wei Zhang; George Capuano; Adam Rogers; Brad J Baker; Michael Cohen; H. Nida Sen; Jeffrey S Heier

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 732. doi:

Metal-organic frameworks for the topical delivery of controlled release Ranibizumab to the retina Open Access

Phillip Harding; Morgan DiLeo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 733. doi:

Impact of Material and Manufacturing Process on Performance of an Ophthalmic Implant Open Access

Hossein Birjandi Nejad; Rokon Zaman; William Smith; Kai-Wei Wu; Xin Feng; Andre O'Reilly Beringhs; Yan Wang; Darby Kozak; Xiaoming Xu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 735. doi:

Stability study of a preservative-free formulation of SYL1801, a siRNA indicated for neovascular AMD, in Novelia® multidose eye dropper Open Access

Veronica Ruz; Beatriz Vargas; Lola Company; Anne-Marie Bleau; Ana Isabel Jimenez

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 736. doi:

Long-term safety and biocompatibility of a biodegradable, thermoresponsive aflibercept-loaded microsphere-hydrogel drug delivery system in nonhuman primates Open Access

Brett D Story; Sangwan Park; Karolina Roszak; Jaeho Shim; Monica Motta; Michelle Ferneding; Kayla M Rudeen; Glenn Yiu; William F Mieler; Sara M Thomasy; Jennifer J Kang-Mieler

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 737. doi:

Binding Characteristics of the VEGF Arm of a Novel Bispecific Protein RO-101 in Comparison to Faricimab-svoa Open Access

Parth Patel; Li Xu; Megana Paidela; John Mitchell Kunzeman; Jessi Prentice; Mark Barakat; Robert Lowenthal; Arshad M. Khanani; Peter M Kaiser; Jeffrey S Heier; Jeffrey L. Olson; Ramanath Bhandari

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 738. doi:

The Characterization of the Ang-2 Arm of a Novel Anti-VEGF-A and Ang-2 Bispecific Protein (RO-101) in Comparison to Faricimab-svoa Open Access

Megana Paidela; Li Xu; Parth Patel; John Mitchell Kunzeman; Jessi Prentice; Robert Lowenthal; Mark Barakat; Arshad M. Khanani; Peter K Kaiser; Jeffrey L. Olson; Jeffrey S Heier; Ramanath Bhandari

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 739. doi:

Accuracy and residual volume of commonly used syringes for intravitreal injection Open Access

Gustavo Melo; Lydianne Agra; Thiago Chagas; Rodrigo Araújo; Larissa Garcez Oliveira; Øystein Kalsnes Jørstad; Morten Carsten Moe

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 740. doi:

Ophthalmologists’ and Optometrists’ Perspectives on the Geographic Atrophy (GA) Landscape Poised on Evolution Open Access

Chrystal Ferguson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 741. doi:

Effect of liposome encapsulation on diffusion kinetics of ripasudil in the polarized retinal pigment epithelial cells Open Access

Rui Ji; Keijiro Ishikawa; Kenichiro Mori; Naoya Matsunaga; Iori Wada; Yosuke Fukuda; Shigehiro Ohdo; Koh-Hei Sonoda

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 743. doi:

TRPM8 Agonists: A New Approach to Dry Eye Disease Treatment Open Access

Mitchell A. deLong; Curtis R. Kelly; Jill Sturdivant; Heeren Gordhan; Cynthia L. Lichorowic; David A. Ellis; Casey C Kopczynski

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 744. doi:

WITHDRAWN_Effects of Levodopa and Other Dopamine Agonists on the Development and Progression of Age-Related Macular Degeneration Open Access

Matthew Driban; Jonathan Joseph; George Tankosich; Jay Chhablani

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 745. doi:

Development of an Ophthalmic Therapeutic, Noregen, with the NEI SBIR/STTR Program Open Access

Kenneth P Mitton; Wendy A Dailey; Michael Thomas Trese; Kimberly A Drenser

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 746. doi:

In vivo CRISPR-KO screens for the study of photoreceptor essential genes and retinal disease modifiers Open Access

Riccardo Sangermano; Egle Galdikaite-Braziene; Sudeep Mehrotra; Eric A Pierce; Kinga Maria Bujakowska

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 747. doi:

Generation and characterization of an adamtsl4 knockout in zebrafish: a novel animal model to study ADAMTSL4-related ocular diseases Open Access

Angel Tevar; Jose-Daniel Aroca-Aguilar; Raquel Atienzar-Aroca; Jesús-José Ferre-Fernández; Julio Escribano

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 748. doi:

POMGNT1 deficiency causes retinal degeneration through triggering RIP-1 dependent necroptotic cell death in a murine model Open Access

Jia-Ying Chien; Shun-Ping Huang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 749. doi:

Optimized prime editing efficiently generates mutations in hiPSCs to model inherited retinal degeneration Open Access

Marcela Garita-Hernandez; Mohammed Zeaiter; Eric A Pierce

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 750. doi:

Mitochondrially targeted gene therapy rescues visual loss in a mouse model of Leber Hereditary Optic Neuropathy. Open Access

Tsung-Han Chou; Diego Alba; Angelina Lazo; Gabriele Gallo Afflitto; Vittorio Porciatti; Hong Yu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 751. doi:

Long-term functional rescue following a AAV-based gene therapy in canine model of LRIT3-congenital stationary night blindness Open Access

Kei Takahashi; Jennifer C Kwok; Yu Sato; Gustavo D Aguirre; Keiko Miyadera

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 752. doi:

CRISPR activation of endogenous CRB1 expression in fibroblasts from retinitis pigmentosa 12 patients Open Access

Sang Yoon Moon; Dan Zhang; Shang-Chih Chen; Tina M Lamey; Jennifer A Thompson; Terri L McLaren; John N DeRoach; Fred K Chen; Samuel McLenachan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 753. doi:

Modifier Gene Approach Using OCU410 for Dry-AMD Therapy: One Gene-Multiple Targets Open Access

Dinesh Kumar Singh; Mohamed Nsaibia; Sree Kattala; Subechhya Neupane; Matthew Ritts; Arun K Upadhyay

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 755. doi:

CRISPR approach for allele-specific targeting of SNPs associated with Age-related Macular Degeneration in ARPE19 cells Open Access

Ahmed Salman; Wonkyung Song; Sarah Young; Michelle E McClements; Robert E MacLaren

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 756. doi:

Testing cone targeting with AAV5 and the GRK1 promoter in mice for future CRISPR-based applications Open Access

Ellen Rhodes; Ahmed Salman; Michelle E McClements; Robert E MacLaren

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 758. doi:

High efficiency in genome editing of pathogenic variants causing Inherited Retinal Dystrophies: the importance of CRISPR/TALEN guides and repair templates designs Open Access

Laura Siles; Sheila Ruiz-Nogales; Arnau Navinés-Ferrer; Paula Gaudó Pardo; Esther Pomares

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 759. doi:

Resolution of retinal cysts following subretinal buffer injection in a mouse model of Juvenile X-linked Retinoschisis Open Access

Jacob Thompson; Ying Hsu; Ella Gehrke; Salma Hassan; Sara Kathryn Mayer; Angela Mahoney; Arlene V Drack

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 760. doi:

Correction of an S Opsin Base-pair Deletion in Hamsters Using CRISPR-Cas9 Open Access

Michelle M Giarmarco; Alexandra F Neitz; James A Kuchenbecker; Zhongde Wang; Yanan Liu; Rong Li; Jay Neitz; Maureen Neitz

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 761. doi:

Results of Belgian patients with RPE65-related inherited retinal dystrophy 6 months after treatment with voretigene neparvovec Open Access

Leen Hertens; Caroline Van Cauwenbergh; Filip Van den Broeck; Julie Sambaer; Manon Van Haute; Pieter Hertens; Elfride De Baere; Geraldine Accou; Fanny Nerinckx; Bart Peter Leroy

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 762. doi:

Improving iPSC-RGC 2D differentiation yield and application to evaluating AAV transduction Open Access

Jarel Gandhi; Jacob Painter; Eswar Saraswathi-Mohan; Yuan-Xing Guo; Yong-Xin Li; Matthew Mason; Mohammed Dibas; Keith A Luhrs

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 764. doi:

Structure-guided GPCR drug development of human single domain camelid antibodies (Nanobody) for autosomal dominant retinitis pigmentosa Open Access

Arum Wu; David Salom; John Hong; Els Pardon; Jan Steyaert; Philip David Kiser; Krzysztof Palczewski

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 765. doi:

Structural and functional assessment after subretinal transplantation of human iPSC-derived photoreceptor precursors in a canine model of end stage retinal degeneration Open Access

William A Beltran; Ana Ripolles-Garcia; Yu Sato; Alexandra Gray; John H Wolfe; Agustin Luz-Madrigal; Michael J Philipps; David M Gamm; Geoffrey K Aguirre; Gustavo D Aguirre

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 766. doi:

Impact of differential sex response to the vector when developing IL-33 gene therapy for AMD Open Access

Alison J Clare; Dave A Copland; Filip Langer; Amy Ward; Ying Kai Chan; Andrew D Dick

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 767. doi:

Modification of rAAV capsid to improve retinal vascular endothelial tropism Open Access

Ramesh Periasamy; Dwani Patel; Sanford L Boye; Shannon E Boye; Daniel M Lipinski

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 768. doi:

Gene therapy restores vision to the all-cone Nrl^-/-/Opn1mw^-/-/Opn1sw^-/- mouse model of blue cone monochromacy Open Access

Marion Cahill; Kathryn Chmelik; Emily R. Sechrest; Robert J. Barbera; Wolfgang Baehr; Wen-Tao Deng

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 769. doi:

RNA editing of mutations causing inherited retinal diseases using the cellular deaminase acting on RNA (ADAR) enzyme Open Access

Dror Sharon; Nina Schneider; Johanna Valensi; Ricky Steinberg; Amit Eylon; Eyal Banin; Erez Levanon; Shay Ben-Aroya

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 770. doi:

Enhanced reduction of vascular leakage with a novel bi-cistronic gene therapy versus anti-VEGF for neovascular age-related macular degeneration Open Access

Emily Warner; Kara Boyd; Laura Vaux; Peter Stuart Widdowson; Katie Binley; Andrew Osborne

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 771. doi:

Gene therapy-associated retinal inflammation may arise from AAV transduction of resident microglia Open Access

Molly John; Joel Quinn; Laurel Chandler; Robert E MacLaren; Kanmin Xue

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 772. doi:

Nonclinical safety and pharmacokinetic assessment of SPVN06, an AAV-based gene therapy for the treatment of rod-cone dystrophies. Open Access

Anne-Sophie Gautron; Melanie Marie; Lucie Churet; Hanen Khabou; Gregg Prawdzik; Thierry Léveillard; José-Alain Sahel; Florence Lorget

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 773. doi:

Silica nanocapsules as a nonviral delivery platform for iPSC-RPE Open Access

Divya Sinha; Yao Tong; Maria A Fernandez Zepeda; Giovanni Hanstad; Emma C Nelson; Cole O Theisen; Shaoqin Gong; David M Gamm

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 774. doi:

TYROSINASE Deficient Human Retinal Pigment Epithelium Exhibits Melanosome Maturation Defects Open Access

Arnold Leigh; Aman George; Tyler Pfister; Charles DeYoung; Ruchi Sharma; Mones Abu-Asab; Jizhong Zou; Kapil Bharti; Brian Patrick Brooks

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 775. doi:

Gene therapy for Wnt signalling-related retinal detachment: Intravitreal injection of AAV.NDP is an effective treatment for vascular exudation in a mouse model of familial exudative vitre... Open Access

James Wawrzynski; Robert Henderson; Valda Pauzuolyte; Aara Patel; Oliver Coombe-Tennant; Dale Moulding; Jane C. Sowden

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 777. doi:

Optimizing Subretinal Bleb Formation in a Porcine Model for Retinal Gene Therapy Open Access

Immanuel Philipp Seitz; Tobias Peters; Bähr Andrea; Hannah Auch; Motlik Jan; Taras Ardan; Yaroslav Nemesh; Stefan Juhas; Nikolai Klymiuk; Dominik M Fischer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 778. doi:

AURN001, a Cell Therapy with Immunomodulatory Properties Required for Long-term Maintenance of the Immunological Homeostasis of the Eye Open Access

Christopher Littlefield; Frada Berenshteyn; Jay Yasin; Maya Davaasuren; Tom Lee; Hao Qi; Xin Qu; Arnaud Lacoste

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 779. doi:

Transduction characteristics of single-stranded and self-complementary AAV2.8 in the porcine retina Open Access

Silja Hansen; Anna Bøgh Lindholm; Thomas Stax Jakobsen; Lars Aagaard; Toke Bek; Anne Louise Askou; Thomas Corydon

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 780. doi:

Intravitreal AAV delivery causes long-term subclinical microglia activation in mice Open Access

Philip Michael Langer; Amy Ward; Oliver Hugh Bell; Alison J Clare; Colin Chu; Ying Kai Chan; Andrew Dick; David Copland

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 781. doi:

Safety and Vision Outcomes of subretinal gene supplementation therapy in PDE6A-associated Retinitis pigmentosa Open Access

Felix Friedrich Lambert Reichel; Stylianos Michalakis; Dominik M Fischer; laura kuehlewein; Tobias Peters; Susanne Kohl; Karl-Ulrich Bartz-Schmidt; Marius Ueffing; Eberhart Zrenner; Martin Biel; Katarina Stingl; Bernd Wissinger

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 782. doi:

Sonogenetic Vision Restoration for Inherited Retinal Disorders Open Access

Subrata Batabyal; Gengxi Lu; Adnan Dibas; Michael Carlson; Sanghoon Kim; Houssam Al Saad; Darryl Narcisse; Mark S. Humayun; Qifa Zhou; Samarendra Mohanty

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 783. doi:

Genetic reprogramming via acute Nr2e3 knockout prevents photoreceptor degeneration Open Access

Dan Murphy; Zaid Khaja; Alexander V Kolesnikov; Vladimir J Kefalov; Joseph Corbo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 784. doi:

Optimizing lipid nanoparticle-mediated photoreceptor transfection in the nonhuman primate. Open Access

Renee Christine Ryals; Milan Gautam; Rene Reynaga; Antony Jozic; Jeonghwan Kim; Elissa Bloom; Rachel Spears; Jonathan Stoddard; Andreas K Lauer; Martha Neuringer; Gaurav Sahay

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 785. doi:

Chromophore-loaded CRALBP nanoparticles restore rod function in chromophore-deficient mice Open Access

Vladimir J Kefalov; Alexander V Kolesnikov; John Cullity; Walter Aeschimann; Achim Stocker

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 786. doi:

Compassionate use of topical beremagene geperpavec (B-VEC) for the treatment of recurrent cicatrizing conjunctivitis in a patient with dystrophic epidermolysis bullosa Open Access

Alfonso L. Sabater; Arianna Tovar; Jennifer Gomez; Trevor Parry; Hubert Chen; Brittani Agostini; Suma Krishnan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 787. doi:

Intravitreal Cerliponase alfa slows the rate of retinal thinning in patients with CLN2 type Batten Disease: A first in man report. Open Access

Robert Henderson; James Wawrzynski; Ana Rodriguez Martinez; Richard Bowman; Rebecca Whiteley; Chin Gan; Louise Harding; Amanda Mortensen; Dorothy Thompson; Paul Gissen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 788. doi:

Fibrin hydrogel encapsulation of adeno-associated virus for transduction of retinal pigment epithelium Open Access

Brittni Scruggs; Francesca Zenti; Emma Trncic; Travis Knudsen; Raymond Iezzi; Alan D Marmorstein

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 789. doi:

Understanding the mechanism of retinal inflammation following subretinal gene therapy Open Access

Kanmin Xue

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 790. doi:

Role of Nrf2 as a therapeutic target for retinal ganglion cell protection Open Access

Qiutang Li; Ting Liu; Chao Cheng; Bin Li

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 791. doi:

Miniature pig model to investigate retinal microglial cells after subretinal injection of rAAV Open Access

Jean-Baptiste Ducloyer; Guylene Le Meur; Joanna Demilly; Lyse Libeau; Delphine Chevalier-Leray; Francoise Roux; Philippe Hulin; Oumeya Adjali; Michel Weber; Therese Cronin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 792. doi:

Anti-Scg3 gene therapy for choroidal neovascularization Open Access

Chengchi Huang; Liyang Ji; Avinash Kaur; Hong Tian; Keith A Webster; Wei Li

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 793. doi:

AAV-mediated selective expression of the SIRT1 gene modulates a gene program of inflammation and retinal ganglion cell survival Open Access

Brahim Chaqour; Miranda Meng; David Camacho; Kimberly Dine; Kenneth S Shindler; Ahmara Gibbons Ross

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 794. doi:

A patient-driven, multi-stakeholder, collaborative approach to address IRD endpoint challenges: the RDH12 example Open Access

Silvia Cerolini; Jean Bennett; Bart Peter Leroy; Tomas S Aleman; Avril Daly; Todd Durham; Courtney Coates; Mathew Pletcher; Sue Lacey

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 795. doi:

SIRT1 Protects Against Oxidative Stress in Human iPSC-RGCs Open Access

David Camacho; Brahim Chaqour; Thu T. Duong; Ahmara Gibbons Ross; Kenneth S Shindler

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 796. doi:

Gene therapy rescues cone function and structure in a novel mouse model of blue cone monochromacy with the most common C203R missense mutation Open Access

Emily R. Sechrest; Robert J. Barbera; Kathryn Chmelik; Marion Cahill; Wen-Tao Deng

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 797. doi:

Correction of Photoreceptor Function and Lipofuscin Deposits in a Model of Stargardt Disease using AAV9 Delivered ABCA4 Hybrid Dual Vectors Open Access

Veluchamy Barathi; Sai Bo Bo Tun; Yeo SiaWey; Chitra Gopinath; Arkasubhra Ghosh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 798. doi:

Evaluation of a novel bi-cistronic gene therapy for the treatment of geographic atrophy Open Access

Andrew Osborne; Kara Boyd; Laura Vaux; Peter Stuart Widdowson; Katie Binley; Emily Warner

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 799. doi:

Kinetically Enhanced Hammerhead Ribozymes Cleave Large Structured Target mRNAs Open Access

Jason M Myers; Jack M Sullivan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 800. doi:

Functional outcomes and adverse effects of voretigene neparvovec for biallelic RPE65-mediated inherited retinal dystrophies in a cohort of patients from a single centre Open Access

Peter Kiraly; Charles Cottriall; Laura J Taylor; Jasleen K Jolly; Jasmina Cehajic-Kapetanovic; Imran H Yusuf; Cristina Martinez-Fernandez dela Camara; Morag Shanks; Susan M Downes; Robert E MacLaren; Dominik M Fischer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 801. doi:

Controlled Release of Adeno-Associated Viruses (AAVs) Using Hydrogel Implants Improve GFP Expression and Reduce Anti-Drug Antibody (ADA) Titers and Inflammation in Rabbits Open Access

Meryem Pehlivaner; Steven Lu; Nelson Bello; Rabia Gurses Ozden; Rami El Hayek; Charles D Blizzard; Peter K Jarrett

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 802. doi:

A ribozyme-mediated RNA replacement gene therapy shows efficacy in a pig model of Autosomal Dominant Retinitis Pigmentosa (adRP). Open Access

Archana Jalligampala; Kautuk Kamboj; Jennifer M. Noel; Elyse Frye; Joseph Prestigiacomo; Olivia Noelle Jacobs; Stephen Nash; Wei Wang; Ji-Hyun Kim; Seong-Wook Lee; Maureen A McCall

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 803. doi:

AAV-based evaluation of novel in silico promoters to drive expression in rod photoreceptors. Open Access

Izabela Paulina Klaska; Paul Sladen; Enrico Mossotto; Tijmen Vermeule; Gemma Estrada Girona; Arifa Naeem; Toyin Adefila-Ideozu; Sophia El-Alami; Monika Pianka; Jasmin Patel; Yanai Duran; Sophia Kleine Holthaus; Amelia Lane; Ce Feng Liu; Tassos Georgiadis

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 804. doi:

Prevalence of myopia in the current young generation in the Netherlands Open Access

Sander Kneepkens; Jan Willem Tideman; Jan Roelof Polling; Caroline C W Klaver

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 805. doi:

Myopia prevalence and lifestyle changes in schoolchildren before, during, and after COVID-19 Restrictions: The Hong Kong Children Eye Study Open Access

Xiu Juan Zhang; Yuzhou Zhang; Fangyao Tang; Ka Wai Kam; Li Jia Chen; Clement C. Tham; Calvin C P Pang; Jason C. Yam

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 806. doi:

An evaluation and follow-up of myopia prevalence among school-aged children subsequent to the COVID-19 home confinement In Feicheng, China Open Access

Xuehan Qian; Jiaxing Wang; Yujie Han; David C. Musch; Ying Li; Nan Wei; Ning Hua; Shuo Li

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 807. doi:

Cohort effects on prevalence of refractive error in US and Korean NHANES Open Access

Timothy R Fricke; Jake Olivier; Serge Resnikoff; Nina Tahhan; Boris Beranger; Suhyun Kweon; Lisa Keay

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 808. doi:

High myopia prevalence in special educational needs children and its link with earlier and longer exposure to electronic screens during the COVID-19 pandemic Open Access

Nga Man Kung; Jordy Lau; Vienne Leung; Kendrick Co Shih

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 809. doi:

Conjunctival autofluorescence (CUVAF) as a biomarker of outdoor exposure in the risk of childhood myopia. Open Access

Sergio Recalde; Miriam De la Puente; Maria Hernandez; Leire Gomez-Arteta; Jaione Bezunartea; Jorge Gonzalez-Zamora; Valentina Bilbao; Manuel Saenz de Viteri; Jesus Barrio-Barrio; Alfredo Garcia-Layana; Patricia Fernandez-Robredo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 810. doi:

Influence of age and race on refractive error progression in myopic children Open Access

Carmen Smotherman; Noel A Brennan; Xu Cheng; Wright Shamp; Ryan Butterfield; Mark A Bullimore

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 811. doi:

Risk factors for fast and slow myopia progression in a randomized controlled trial of 0.01% atropine eye drops Open Access

Matilda Biba; Gareth Lingham; Emmanuel Kobia-Acquah; Ian Flitcroft; James Loughman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 812. doi:

Comparison of myopia progression calculators Open Access

Monica Jong; Noel A Brennan; Xu Cheng; Mark A Bullimore

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 814. doi:

Myopia progression before, during and after the COVID-19 pandemic in North American children Open Access

Marcella McParland; Deborah Laughton; Jennifer Hill; Vanessa Tasso; Jay Neitz; Maureen Neitz; Thomas Chalberg

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 815. doi:

Efficacy in Myopia Control—Three-year Predictions from the LAMP Study Open Access

Mark A Bullimore; Noel A Brennan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 816. doi:

The Use of Atropine 0.025% in the Treatment of Childhood Myopia - a Retrospective Study Open Access

Aaron Qi Yang Goh; Bryan Xiang Rong Sim; Audrey Wei Lin Chia

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 817. doi:

Change in pupil size with atropine 0.01% is not associated with myopia control efficacy Open Access

Emmanuella Esi Dadzie; Emmanuel Kobia-Acquah; Ian Flitcroft; Matilda Biba; James Loughman; Gareth Lingham

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 818. doi:

Uniformity of treatment benefit in multifocal contact lens myopia control Open Access

Donald O Mutti; Loraine T Sinnott; David A Berntsen; Lisa Jordan; Jeffrey J Walline

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 819. doi:

Light Exposure Therapy for Myopia Control: A Systematic Review and Network Meta-Analysis Open Access

EBENEZER ZAABAAR; Xiu Juan Zhang; Fangyao Tang; Clement C. Tham; Calvin C P Pang; Li Jia Chen; Jason C. Yam

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 820. doi:

Cost-Effectiveness Analysis of Atropine for Treating Myopia Progression in Children Open Access

Sylvia Agyekum; Xiu Juan Zhang; Poemen Pui Man Chan; Yuzhou Zhang; Zhaohua Huo; Benjamin HK Yip; Clement C. Tham; Li Jia Chen; Calvin C P Pang; Jason C. Yam

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 821. doi:

Descriptive statistical comparison of interventions for myopia control Open Access

Paul Gifford; Kate Gifford

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 822. doi:

Efficacy in Myopia Control—Odds Versus Absolute Effect Open Access

Xu Cheng; Paul Weiss; Mark A Bullimore; Noel A Brennan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 823. doi:

The limits of evidence-based myopia control Open Access

Kate Gifford; Clare Maher; Paul Gifford

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 824. doi:

Global trends in myopia management attitudes and strategies in clinical practice – 2022 Update Open Access

Yasmin Whayeb; James S.W Wolffsohn; Nicola S Logan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 825. doi:

Pattern of myopic macular degeneration in the Aier-SERI High myopia adult cohort in Changsha, central China Open Access

Seang-Mei Saw; Ziqi Hu; Li Lian Foo; Hla Myint Htoon; Huanhuan Tan; Ecosse Luc Lamoureux; Zhikuan Yang; Quan V Hoang; Weizhong Lan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 826. doi:

High myopia maculopathies distribution characteristics based on OCT. Open Access

Anas Ziad Masoud Abu Said; Yanfeng Su; ShiHao Chen; ShuangQian Zhu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 827. doi:

Exploring causal effects of age at myopia onset on multiple diseases using electronic health records: a phenome-wide and polygenic risk study Open Access

Xiayin Zhang; Huang Yu; Yanjie Xie; Xianwen Shang; Shunming Liu; Zhuoting Zhu; Honghua Yu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 828. doi:

Comparison of two phone models to detect myopia in children and adults Open Access

Ling-yau Kiu; Oi Lam Kwok; Ho Cheung Leung; Paul H Lee; Grace Ngai; Hong va Leong; Chi-wai Do; Lily, Y.L Chan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 829. doi:

Distribution of axial length in Australians of different age groups, ethnicities, and refractive errors Open Access

Vinay Kumar Nilagiri; Samantha Sze-Yee Lee; Gareth Lingham; Jason Charng; Seyhan Yazar; Alex W Hewitt; Lyn Griffiths; Paul Sanfilippo; Tzu-Hsun Tsai; David Mackey

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 831. doi:

Axial length and axial length growth in a German cohort Open Access

Torben Gräber; Philipp Hessler; Stephan Degle

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 832. doi:

A Longitudinal Study of Refractive Error Changes in Hispanic and Black Children over 4 Consecutive Years Open Access

Yi Pang; qiong li; Sandra S Block; Jingyun Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 833. doi:

Longitudinal Change in Astigmatism in Adolescent Australian Schoolchildren Open Access

Amanda French; Kathryn Ailsa Rose

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 834. doi:

NOS Expression in Chick Ocular Tissues in Response to Myopic Defocus Open Access

Jody A Summers; Diana Soriano

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 835. doi:

Immunohistochemical studies on the distribution and localization of dopamine in the chicken choroid Open Access

Ute Mathis; Alexandra Kaser-Eichberger; Marita P Feldkaemper; Frank Schaeffel; Falk Schroedl

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 837. doi:

Evening blue light exposure stimulates eye growth and reduces the vitreal DOPAC rhythm Open Access

Debora L Nickla; Xia Wang; Lixin Zhang; Christopher Patrick Taylor; Arthur Watson; Richard A Stone; Jendayi Dixon; P. Michael Iuvone

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 838. doi:

Effect of chromatically filtered videos on choroidal thickness in chickens. Open Access

Marita P Feldkaemper; Hong Liu; Frank Schaeffel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 839. doi:

Intermittent exposure to illuminances of 5500 lux considerably prevents myopia development and increases scleral stiffness in chicks Open Access

Raymond P. Najjar; Muralidharan Arumugam Ramachandran; Yong Chong Lee; Royston K.Y. Tan; Lei Zhou; Michael J A Girard; Dan Milea; Seang-Mei Saw; Veluchamy Barathi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 840. doi:

Effects of Daily Transient Lens-Induced Myopic Defocus on the Inhibition of Myopia Progression in Chicks Open Access

Svetlana Nunez Flores; Steven Lee; So Goto; Christine Frances Wildsoet

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 841. doi:

Astigmatic Blur Influences The Development and Recovery of Myopic-Astigmatism in Chickens Open Access

Sonal Aswin Vyas; Byung Soo Jeremy Kang; Chea-Su Kee

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 842. doi:

Rod pathway electrical activity is modulated in the myopic mouse Open Access

Reece Mazade; Machelle T Pardue

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 843. doi:

Effects of acute light exposure on retinal dopamine and adenosine Open Access

Sarah Talwar; Reece Mazade; Machelle T Pardue

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 844. doi:

Effects of exogenous retinoic acid on retinal and choroidal parameters in guinea pigs with form deprivation myopia using enhanced depth imaging optical coherence tomography Open Access

Yajun Wu; Wensheng Li

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 845. doi:

Like atropine, the anti-myopic effects of pirenzepine can be disrupted by serotonergic stimulation in chicks Open Access

Nichola Hoffmann; Kate Thomson; Cindy Karouta; Regan Ashby

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 846. doi:

Effect of OCT Alignment on Ocular Parameters in the Mouse Eye Open Access

Linjiang Lou; Katelyn M Hall; Machelle T Pardue

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 847. doi:

Tear secretion in lens induced myopia mouse models. Open Access

Ziyan Ma; Heonuk Jeong; Shin-ichi Ikeda; Jing Hou; Junhan Chen; Kazuno Negishi; Toshihide Kurihara; Kazuo Tsubota

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 848. doi:

Second Harmonic Generation Microscopy of Rat Scleral Remodeling by Collagenase and Reparative Collagen Mimetic Peptides Open Access

Daniel E. Savage; Jiaxi Zhou; James Andrew Germann; Robert O. Baratta, MD; Brian J Del Buono; Eric Schlumpf; Susana Marcos

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 849. doi:

Second Harmonic Generation Microscopy and Quantification of Collagenase Digestion on Rat Sclera Open Access

Jiaxi Zhou; James Andrew Germann; Daniel E. Savage; Susana Marcos

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 850. doi:

Choroidal Resident Macrophage Depletion can Induce Myopia in Mice Open Access

Jing Hou; Shin-ichi Ikeda; Kiwako Mori; Heonuk Jeong; Hidemasa Torii; Kazuno Negishi; Kazuo Tsubota; Toshihide Kurihara

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 851. doi:

Lens-induced myopia alters scleral fibroblast populations in mice Open Access

Melissa Bentley-Ford; Reece Mazade; C Ross Ethier; Machelle T Pardue

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 852. doi:

Scleral Thrombospondin-1 knockdown induces axial elongation of mice eyes Open Access

Junhan Chen; Shin-ichi Ikeda; Yajing Yang; Kazuno Negishi; Kazuo Tsubota; Toshihide Kurihara

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 853. doi:

MOLECULAR MECHANISMS OF MYOPIC STAPHYLOMA (MS) Open Access

kimberley delaunay; Alicia Torriglia; Marta Zola; Renata Kozyraki; olivier cases; Jose Maria Ruiz Moreno; Francine F Behar-Cohen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 854. doi:

The Effect of Inhibition of Rho Associated Kinase on Myopia Development in the Guinea Pig Open Access

Sally A McFadden; Sara Cummings; Yusupjan Abdulla; William Myles; Quan V Hoang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 855. doi:

Purinergic receptors as a new molecular mechanism implicated in the axial length growth. Open Access

LAURA DE DIEGO GARCIA; GONZALO VALDES SORIA; MARIA ROMAGUERA PLANELLS; Alba Martin-Gil; Gonzalo Carracedo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 857. doi:

Using the Limited Spectral Bandwidth Animal Model of Myopia to Evaluate The Timing of Breaks from Anti-Myopiagenic Stimuli Open Access

Timothy Gawne; Zhihui She

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 858. doi:

Expression of SERPINE3 is bidirectionally altered in refractive error Open Access

Ross F Collery

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 859. doi:

Characterization of human scleral fibroblasts as an in vitro model for myopia Open Access

Jacinth Priscilla Jacob Jayakumar; Krista M Beach; Vivien Jane Coulson-Thomas; Lisa Ostrin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 860. doi:

Utilization of Low Vision Services for Patients with Neovascular Age-Related Macular Degeneration Open Access

David J Ramsey; Courtney Sweeney; Mahesh K Bhardwaj

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 861. doi:

Assessing Eye Clinic Design and Accessibility Features Open Access

Jason Dossantos; Hassaam Choudhry; Laura Mazudie Ndjonko; Anne Riddering; Mona Kaleem

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 862. doi:

Clincal vision assessment practice in Norwegian stroke units Open Access

HELLE K Falkenberg; Marte F Rosenvinge

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 863. doi:

Practice Patterns of Low Vision Services among Optometrists in Ghana Open Access

Kofi Osei-Poku; Werner Eisenbarth; Elna Abadua Mensah; Isaiah Junior Osei Duah; Eldrick Adu Acquah; Emmanuel Kofi Addo; Josephine Ampomah Boateng; David Ben Kumah; Nana Aba Senuwah Ashon; Samuel Aikins Jr; Kwadwo Owusu Akuffo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 864. doi:

Occupational therapists' self-rated service delivery satisfaction and vision loss accomodation during the cognitive screening of clients living with vision loss. Open Access

Shirley Dumassais; Walter Wittich

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 865. doi:

Adaptations to the administration of informed consent when conducting research with older adults that are deafblind Open Access

Norman Robert Boie; Atul Jaiswal; Walter Wittich

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 866. doi:

Using Patient Health Records to Assess Clinician Effectiveness in Low Vision Rehabilitation Open Access

Dominic Brown; Chris Bradley; Gislin Dagnelie; Robert W Massof; Judith E Goldstein

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 867. doi:

Association between vision-specific symptoms, mental health and fatigue using structural equation modeling in adults with vision loss Open Access

Ruth van Nispen; Wouter Schakel; Hilde P. van der Aa; Ger van Rens; Christina Bode

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 868. doi:

Violet Light Therapy for Improving Sleep Quality: a Pilot Study Open Access

Yasue Mitsukura; Brian Sumali; Motoshi Hayano; Kazuo Tsubota

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 869. doi:

Exploring the relationship between the self-reported impact of Charles Bonnet Syndrome on quality of life and parameters of overall wellbeing Open Access

Bethany Elora Higgins; Deanna J Taylor; Tamsin Callaghan; David Crabb

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 870. doi:

Determinants of vision-related quality of life of children and young people with visual impairment Open Access

Ana Semrov; Valerija Tadic; Mario Cortina Borja; Jugnoo Rahi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 871. doi:

What are the activity and participation needs for persons with vision loss in Flanders? Open Access

Lorenzo Billiet; Ruth van Nispen; Hilde P. van der Aa; Stijn De Baets; Dominique Van de Velde

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 872. doi:

Understanding the impacts on caregivers who support individuals with eye conditions and vision loss Open Access

Larissa Moniz; Jennifer Pereira; Morgan Ineson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 873. doi:

Relationship between Physical and Psychological Functioning and Health-Related Quality of Life in Congenital Aniridia Open Access

Erlend Christoffer Sommer Landsend; Charlotte von der Lippe; Line Mediå; Jeanette Ullmann Miller; Solrun Sigurdardottir

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 874. doi:

Gene expression signature associated with hypoxia in human uveal melanoma cells Open Access

Hua Yang; Stefan Kaluz; Satoru Osuka; Margaret Offermann; Erwin Van Meir; Hans E Grossniklaus

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 875. doi:

The anti-tumor efficiency of bel-sar (AU-011) treatment in a melanotic and an amelanotic (TYR knockout) B16F10 model in vitro and vivo Open Access

Sen Ma; Ruben V Huis In’t Veld; Cadmus Rich; Ferry A Ossendorp; Martine J Jager

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 876. doi:

Clinically residual pigmentation in post-treatment conjunctival melanoma may not be neoplastic in nature Open Access

Imani M. Williams; Anna M. Stagner

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 877. doi:

Intravitreal Dexamethasone Implant in the Treatment of Exudative Retinal Detachment Secondary to Posterior Uveal Melanoma Open Access

Raffaele Parrozzani; Giulia Midena; Alessandro Busatta; Luisa Frizziero; Edoardo Midena

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 878. doi:

Characterization of uveal melanoma-derived EV protein cargo for the determination of new therapeutic targets Open Access

Mohamed Abdouh; Thupten Tsering; Carmen Luz-Pessuti; Miguel N. Burnier; Emma Youhnovska; Julia Valdemarin Burnier

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 879. doi:

Impact of Gene Expression Profiling on Diagnosis and Survival after Metastasis in Patients with Uveal Melanoma Open Access

Ashley Go; Disorn Suwajanakorn; Anne Marie Lane; Caleb Hartley; Monica Oxenreiter; Mary E Aronow; Evangelos S Gragoudas; Ivana K Kim

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 880. doi:

Delineating three-dimensional behavior of uveal melanoma cells under anchorage independent or dependent methods Open Access

Alicia Alejandra Goyeneche; Jade Marie Lasiste; Prisca Bustamante; Mohamed Abdouh; Julia Valdemarin Burnier; Anne Xuan-Lan Nguyen; Miguel N. Burnier

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 881. doi:

GNAQ/11 and BAP1 mutant isogenic cell lines engineered by CRISPR/Cas9 to model ocular melanoma Open Access

Aurélie Fuentes-Rodriguez; Andrew Mitchell; Solange Landreville

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 882. doi:

Mass spectrometry-based profiling of histone posttranslational modifications in human uveal melanoma tissue Open Access

Martina C Herwig-Carl; Amit Sharma; Roberta Noberini; Karin U Loeffler; Frank G Holz; Natalie Pelusi; Verena Tischler; Tiziana Bonaldi; Claudia Auw-Hädrich

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 883. doi:

The Cancer Genome Atlas cytogenetic analysis of choroidal nevus with transformation to melanoma Open Access

Kevin R. Card; Alexandra R. Zaloga; Eleni Konstantinou; Carol L. Shields

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 884. doi:

The Rim Creeper: Edge creep, increased pigmentation at the border of choroidal melanomas treated with plaque brachytherapy Open Access

Sean Michael Rodriguez; Elaine Binkley; H Culver Boldt; Connie Hinz

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 885. doi:

Proteomic characterisation of the extracellular matrix in high metastatic risk uveal melanoma Open Access

Helen Kalirai; Karen Aughton; Sarah E Coupland

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 886. doi:

Clinical Characteristics of Patients with Uveal Melanoma and Indeterminate Melanocytic Choroidal Tumors Open Access

Sabrina Iddir; John Michael Bryan; Jacob Love; Sanjay Ganesh; Darvin Yi; Michael J Heiferman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 887. doi:

Chromosome 8q gain occurs decades before diagnosis of primary uveal melanoma Open Access

Yong Joon Kim; Christopher Seungkyu Lee

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 888. doi:

Optic Nerve and Intraocular Pressure Asymmetries in the Diagnosis of Iris Melanoma Open Access

Alan William Kong; Adrian Au; Weilin Song; Angela Oh; Tara McCannel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 889. doi:

Clinical features of choroidal melanomas previously managed by non-ocular oncologists. Open Access

Ethan Willis; Anderson Brock; David Reichstein

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 890. doi:

Neuropilin-2 inhibition in uveal melanoma results in decreased proliferation and viability and enhances the apoptotic response Open Access

Ludwig M Heindl; Nasrin Refaian; Michael Simon; Alexander Christopher Rokohl; Daria Lehrmann

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 891. doi:

Outcome of combined cataract surgery and iris prosthesis implantation in patients with previous iris melanoma surgery Open Access

Jens F Kiilgaard; Kristoffer Nissen; Simon Persson Skibsted; Carsten Faber; Tine Gadegaard Gadegaard Hindsø; Per Riise; Rasmus Ejstrup; Mette Bagger

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 892. doi:

Predicting Survival from Choroidal Melanoma Utilizing Multilayer Perceptron Artificial Neural Network Open Access

Brian Firestone; Zain Hussain; Asad Loya; Matthew W Wilson; Siamak Yousefi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 893. doi:

Radiation prescription for uveal melanoma: apical dose versus volume dose Open Access

Jeremy P. M. Flanagan; Roderick F O'Day; William H F Udovenya; Lotte S Fog

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 894. doi:

Metastatic spread from primary eye tumor after enucleation in a Uveal Melanoma orthotopic human to mouse xenograft model Open Access

Alice van den Broek; Nasrin Refaian; Cindy Hoppe; T.H. Khanh Vu; Martine J Jager; Bruce Ksander; Margarete Karg

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 895. doi:

Metastatic patterns in posterior uveal melanoma Open Access

Tine Gadegaard Gadegaard Hindsø; Karine Madsen; Camilla Wium Bjerrum; Carsten Faber; Kristoffer Nissen; Steffen Heegaard; Mette Bagger; Jens F Kiilgaard

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 896. doi:

Multimodal imaging risk factors predictive of small choroidal melanocytic lesion growth to melanoma: An educational study and pictorial guide Open Access

Trisha Yuuno Castillo Pecoraro; Robert Churchill; Andrea A. Tooley; Odette Houghton; Arman Mashayekhi; Lauren A Dalvin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 897. doi:

Clinical characteristics and outcomes in young patients with uveal melanoma from the mid-south United States Open Access

Ilyse Kornblau; Benjamin A King; LINDA A A CERNICHIARO-ESPINOSA; Matthew W Wilson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 898. doi:

Tumorigenic properties of uveal melanoma cancer cells cultured in 3D or on a reconstructed extracellular matrix Open Access

Olivier Chancy; Léo Piquet; Kelly Coutant; Solange Landreville

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 899. doi:

The Role of Macrophages in Vascular Formation in Uveal Melanoma Open Access

Hans E Grossniklaus; Nicholas Zhang; Carmen Morote Garcia; Ahmet Coskun; Jana T Sellers; Yutao Yan; Karina Bostwick; Hua Yang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 900. doi:

Identifying predictors of vision loss following plaque brachytherapy treatment for uveal melanoma Open Access

Florian Guillot; Audra Miller; Misty Kosydar; Erin Kaya; Jenna Kahn; Christina Binder; Alison Skalet

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 901. doi:

One-shot vs. fractionated stereotactic radiosurgery (SRS vs. FSR) for intraocular uveal melanoma Open Access

Ori Saban; Jacob Pe'er; Maya Eiger-Moscovich; Shahar Frenkel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 902. doi:

The metastatic uveal melanoma cell line OMM2.5 displays selective sensitivity to the synthetic cannabinoid HU-210 Open Access

Marzia Pendino; Valentina Tonelotto; Sandra Garcia Mulero; Rebeca Sanz Pamplona; Simone Marcone; Fiona O’Connell; Eugene T. Dillion; Cristina Casalou; Desmond J Tobin; Jacintha O'Sullivan; Alberto Villanueva; Josep M. Piulats; Breandan N Kennedy

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 903. doi:

Brachytherapy with Silicone Oil to Prevent Radiation in Large Choroidal Melanoma Open Access

Angela Oh; Adrian Au; Alan William Kong; Weilin Song; Mahir Hasan; Tara McCannel

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 904. doi:

The tumor microenvironment influences response of uveal melanoma cells to FAK inhibitors (FAKi). Open Access

Karen Aughton; Joseph Sacco; Mark Devlin; Sarah E Coupland; Helen Kalirai

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 905. doi:

Uveal melanomas presenting in the anterior segment of the eye: Anatomical localization and survival rate Open Access

Kristoffer Nissen; Astrid-Helene Jørgensen; Mette Bagger; Tine Gadegaard Gadegaard Hindsø; Carsten Faber; Rasmus Ejstrup; Steffen Heegaard; Jens F Kiilgaard

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 906. doi:

Multiplying Brown Spots Open Access

Amer Alsoudi; Matthew Parvus; Jose Pulido; Patricia Chevez-Barrios; Bin Teh; Eric Bernicker; Amy C Schefler

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 907. doi:

Validation of a Novel Approach to Estimate Choroidal Lesion Thickness Using 2D Ultra-widefield Optomap Images Open Access

Aneesha Ahluwalia; Michael Yu; Michael Heiferman; Edward Korot; Gina Yu; Prithvi Mruthyunjaya

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 908. doi:

An observational population-based study of uveal melanoma in England: The impact of route to diagnosis on tumour management and survival Open Access

Gavin Reynolds; Beth Stuart; sandro Fasolo; Mandeep sagoo; Denize Atan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 909. doi:

Discovering the pathogenesis of cancer dissemination: The role of dual nature – hybrid cells in Uveal Melanoma Open Access

Emily Marcotte; Dulce Lopez; Alicia Alejandra Goyeneche; Mohamed Abdouh; Emma Nikolaeva Youhnovska; Sabrina Bergeron; Ana Beatriz Dias; Miguel N. Burnier

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 910. doi:

Factors predictive of interval growth between diagnosis of uveal melanoma and planned brachytherapy Open Access

Nicole Paola Rebollo; Anthony Brent Daniels

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 911. doi:

PET/CT screening can be an effective tool for detecting uveal melanoma metastases: Results from a population-based study Open Access

Nikki Chopra; Trafford Crump; Ezekiel Weis

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 912. doi:

Transcriptomic and exomic sequencing analysis of the living library for uveal melanoma Open Access

Cynthia Pfannkoch; Sam Adams Erickson; David R Miley; Lauren A Dalvin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 913. doi:

Uveal melanoma cells exhibit variable growth patterns and distinct mitochondrial respiration profile compared with primary human uveal melanocytes. Open Access

Piotr K Kopinski; Anna N Ligezka; Tamas Kozicz; Eva Morava; Lauren A Dalvin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 914. doi:

Hepatic pre-metastatic niche formation by uveal melanoma extracellular vesicles Open Access

Kelly Coutant; Andrew Mitchell; François Bordeleau; Solange Landreville

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 915. doi:

Impact of phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC) inhibition on uveal melanoma viability and downstream gene expression Open Access

David R Miley; Cynthia Pfannkoch; Sam Adams Erickson; Lauren A Dalvin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 916. doi:

Development of Fibrosis and Atrophy in nAMD in regard to fluid volume (IRF, SRF, PED) and fluctuation localization (1, 3, 6mm) Open Access

Guenther Weigert; Gabor Deak; Martin Michl; Gregor Sebastian Reiter; Daniela Boryshchuk; Florian Frommlet; Stefan Sacu; Bianca S Gerendas; Ursula Schmidt-Erfurth

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 917. doi:

Initial Manifestation of Complete Retinal Pigment Epithelium and Outer Retinal Atrophy (cRORA) in Age-related Macular Degeneration: Associations With Genetic Risk Profile Open Access

Steffen Schmitz-Valckenberg; Monika Fleckenstein; Christian Pappas; Jill Hageman; Moussa A Zouache; Gregory S Hageman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 918. doi:

Therapeutic effect of pegcetacoplan on retinal pigment epithelium (RPE) and photoreceptor (PR) integrity in geographic atrophy (GA) in the phase III OAKS and DERBY trials Open Access

Ursula Schmidt-Erfurth; Julia Mai; Gregor Sebastian Reiter; Wolf-Dieter Vogl; Amir Sadeghipour; Alex Scott McKeown; Hrvoje Bogunovic

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 919. doi:

Incomplete RPE and Outer Retinal Atrophy (iRORA) Development in Dry Age-Related Macular Degeneration (AMD) in Patients with Fellow-Eye Neovascular AMD Open Access

Hanna Choi; Giulia Corradetti; Sophiana Lindenberg; Ayesha Nuri Karamat; Deniz Oncel; Henry Liu; Ramya Gnanaraj; Sohaib Fasih-Ahmad; Kenneth Marion; Kirstie Baker; Shilpa Gulati; Bradley Foster; Andrew Lam; SriniVas R Sadda; David Lally

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 920. doi:

Choriocapillaris flow impairment under the fovea is associated with delayed rod-mediated dark adaptation in the perifovea of eyes with early and intermediate age-related macular degenerat... Open Access

Deepayan Kar; Giulia Corradetti; Mohymina Amjad; Thomas A. Swain; Mark E. Clark; Gerald McGwin; Cynthia Owsley; Kenneth R Sloan; SriniVas R Sadda; Christine A. Curcio

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 921. doi:

Onset and progression of persistent choroidal hypertransmission defects in intermediate AMD: A novel clinical trial endpoint Open Access

Jeremy Liu; Mengxi Shen; Rita Laiginhas; Gissel Herrera; Jianqing Li; Yingying Shi; Farhan E. Hiya; Omer Trivizki; Nadia K Waheed; Carol Y Chung; Eric M Moult; James G. Fujimoto; Giovanni Gregori; Philip J Rosenfeld

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 922. doi:

Progressive damage to retinal pigment epithelial cells near subretinal drusenoid deposits revealed using adaptive optics Open Access

Joanne Li; Tao Liu; Nancy Aguilera; Furu Zhang; Andrew J. Bower; Emily Y. Chew; Tiarnan D L Keenan; Catherine Cukras; Johnny Tam

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 923. doi:

A PHASE I/IIA TRIAL TO TEST SAFETY AND FEASIBILITY OF AN AUTOLOGOUS IPS CELL-DERIVED RETINAL PIGMENT EPITHELIUM PATCH IN AGE-RELATED MACULAR DEGENERATION PATIENTS Open Access

Kapil Bharti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 924. doi:

A bioengineered RPE implant for dry age-related macular degeneration Open Access

Dennis O. Clegg

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 925. doi:

Advancing photoreceptor replacement therapy using adaptive optics ophthalmoscopy in primate Open Access

Juliette E McGregor

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 926. doi:

Tissue engineering a retinal patch using stem cell-derived photoreceptors Open Access

Jane C. Sowden

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 927. doi:

Tree shrew model of glaucoma and RGC replacement Open Access

Brian C. Samuels

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 928. doi:

Retinal engineering and RGC replacement - Enhancing the integration of transplanted RGCs Open Access

Thomas Johnson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 929. doi:

Delivering topical IL-33 mRNA + nanoparticles to treat neovascular age-related macular degeneration. Open Access

Lisa J Hill; Chloe Thomas; Alison Clare; Lynn Jena; Chris Weston; Eleanor Hickman; Jamie Cowley; Alastair K Denniston; Andrew D Dick; Dave A Copland; Helen O McCarthy

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 930. doi:

The DAVIO trial: a phase 1, open-label, dose-escalation study of a single injection of EYP-1901 (vorolanib in Durasert^® platform) demonstrating reduced treatment burden in wet age-related... Open Access

Ashkan Michael Abbey; Sunil S Patel; Mark Barakat; Vrinda S Hershberger; William Z Bridges; David Aaron Eichenbaum; David Lally; Philip P Storey; Monica Roy; Jay S Duker; Dario A Paggiarino

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 931. doi:

Sustained release griseofulvin microparticles offer long-term therapy for choroidal neovascularization in a preclinical model Open Access

Timothy William Corson; Dhawal Chobisa; Anbukkarasi Muniyandi; Yoon Yeo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 932. doi:

Transcriptional regulation of immunometabolism modulates macrophage (M0) behaviour and protects against the onset and expansion of atrophy in a rodent model of age related macular degener... Open Access

Shelley R Boyd; Matthew Mina Reyad; David Sung Heon Baek; Rahul Joshi; Hai Wang; Xu Zhao; Natalie Pankova

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 933. doi:

Development of an RNA Targeting Based Gene Therapy Product for Neovascular Age-Related Macular Degeneration (nAMD) Open Access

Linyu Shi; Shaoran Wang; Weiwei Wu; Xing Wang; Qi Yang; Jingyu Zhang; Sheng He; Hongting Du; Jipeng Song; Chenhua Yang; Mengke Zhu; Xuan Yao; Hui Yang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 934. doi:

Ref-1 inhibitor APX2009 is antiangiogenic in murine choroidal neovascularization and human choroidal endothelial cells Open Access

Anbukkarasi Muniyandi; Kamakshi Sishtla; Gabriella Hartman; Yang Song; Andi R Masters; Sara K Quinney; Mark R Kelley; Timothy William Corson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 935. doi:

U.S. Phase 1 Study of Intravitreal Axitinib Implant (OTX-TKI) for Neovascular Age-related Macular Degeneration Open Access

Andrew A Moshfeghi; Arshad M. Khanani; David Aaron Eichenbaum; Charles Clifton Wykoff; Stephen Couvillion; Samantha Xavier; Nathan Steinle; Peter Kaiser; Rabia Gurses Ozden

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 936. doi:

Bone Morphogenic Protein 4 (BMP4); a potential player in diabetic retinopathy Open Access

Julia Humble; Noureldien Darwish; Khaled Elmasry; Mohamed Moustafa; Fatma Awadalla; Ahmed Ibrahim; Mohamed Al-Sayed Al-Shabrawey

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 937. doi:

LP-ACE2 attenuates diabetic visual impairment by improving gut barrier integrity and intestinal lymphatics in type 1 diabetes Open Access

Ram Prasad; Jason Floyd; Yvonne Adu-Agyeiwaah; Bright Asare-Bediako; Sergio Li Calzi; Dibyendu Chakraborty; Angela Harbour; Aayush Rohella; Irina A Pikuleva; Julia V. Busik; Qiuhong Li; Maria B Grant

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 938. doi:

The impact of forced circadian misalignment on the progression of diabetic retinopathy Open Access

Hanagh Winter; Katie Dunlop; Thomas Friedel; Josy Augustine; Tim M Curtis; Alan Stitt; Eleni Beli

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 939. doi:

Role of Mitochondrial Targeted RNase in the Regulation of Mitochondrial Genome-encoded Long Non-coding RNA in Diabetic Retinopathy Open Access

Ghulam Mohammad; Renu A. Kowluru

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 940. doi:

Inhibition of ceramide rich platforms by anti-ceramide immunotherapy prevents retinal endothelial cell damage and the development of diabetic retinopathy. Open Access

Tim F. Dorweiler; Arjun Singh; Richard N Kolesnick; Julia V. Busik

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 941. doi:

Retinal vascular permeability as a preclinical biomarker for diabetic retinopathy Open Access

Sarah Vavrek; Elif Nalbant; Nicholas Konopek; Ghazi Bou Ghanem; Amani A Fawzi; William F Mieler; Kenneth Tichauer; Jennifer J Kang-Mieler

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 942. doi:

Alternative pro-angiogenic pathways during diabetic retinopathy – Microglia response towards ANG-2 Open Access

Antonia M Joussen; Chufan Asu Yan; Bilge Ugursu; Susanne Asu Wolf

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 943. doi:

Cre-mRNA-mediated induction of mutant myocilin in trabecular meshwork leads to ocular hypertension in an inducible transgenic mouse model of myocilin glaucoma Open Access

Sam Yacoub; Balasankara reddy kaipa; Linya Li; Gulab Zode

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 944. doi:

Description of a nonhuman primate model of retinal ischemia-reperfusion injury model Open Access

Wen Zeng; Louis R Pasquale; Li Gong; Janey L Wiggs; Lingzhen Pan; Zhenyan Yang; Mingling Wu; Zunyuan Yang; Yubo Shen; Dongfeng Chen

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 945. doi:

Retinal Nerve Fiber Layer Measurement Reproducibility with Varying Sampling Patterns and Locations in Rhesus Macaque Eyes. Open Access

Palaiologos Alexopoulos; Ronald Zambrano; TingFang Lee; Jiyuan Hu; Anse Vellappally; Rania Zaki; Arturo O Barron; James Higham; Amanda Melin; John Danias; Hiroshi Ishikawa; Joel S Schuman; Gadi Wollstein

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 946. doi:

Role of AP-2β in Anterior Segment Development and Glaucoma Open Access

Judith A West-Mays; Terete Borras; Aftab Taiyab; Trevor Williams

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 947. doi:

A System for Controlled Elevation of Intraocular Pressure (IOP) in Unanesthetized Rat Eyes Open Access

John C Morrison; William O Cepurna; Aryana Abtin; Susan Wentzien; Elaine Johnson; Diana C Lozano

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 948. doi:

Helper Ad5.Cre-induced mutant myocilin expression in trabecular meshwork develops glaucoma in an inducible transgenic mouse model of myocilin glaucoma Open Access

Balasankara reddy kaipa; Sam Yacoub; Ramesh Kasetti; Linya Li; Gulab Zode

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 949. doi:

24-Hour Telemetric IOP Monitoring in Rabbits Open Access

Arthur J Sit; Christopher K Gow; J Crawford C Downs; Kjersten J Anderson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 950. doi:

Delivering energy - structure, and function of cone photoreceptor mitochondria Open Access

Wei Li

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 951. doi:

Mitochondrial homeostasis in the healthy and diseased cornea Open Access

Danielle M. Robertson

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 952. doi:

Enhanced mitochondrial metabolism promotes differentiation of the retinal pigment epithelium following treatment with nicotinamide Open Access

Roni A. Hazim

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 953. doi:

Mitochondrial Instability in Diabetic Retinopathy Open Access

Renu A. Kowluru

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 954. doi:

Metabolic perturbations during the progression of retinal degenerative disease Open Access

Katherine J. Wert

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 955. doi:

Alteration of immune cell metabolism during herpes stromal keratitis Open Access

Anthony St. Leger

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 956. doi:

The effect of the dopamine reuptake inhibitor Ritalin on the development of experimental myopia Open Access

Cindy Karouta; Kate Thomson; Lauren Booth; Ian George Morgan; Regan Ashby

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 958. doi:

Modulation of BMP2 expression in guinea pig retinal pigment epithelium during induction of and recovery from contact lens-induced myopia Open Access

So Goto; Yan Zhang; Christine Frances Wildsoet

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 959. doi:

Postnatal eye size in mice is controlled by SREBP2-mediated transcriptional repression of Lrp2 and Bmp2 Open Access

MAI SHUYI; Xiaoxuan Zhu; Esther Yi Ching Wan; Shengyu Wu; Jesslyn Nagalin Yonathan; Jun Wang; Ying Li; Jessica Yuen Wuen Ma; Bing Zuo; Dennis Yan-yin Tse; Pui-Chi Lo; Xin Wang; Kui Ming Chan; David M Wu; Wenjun Xiong

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 960. doi:

The Axis of Astigmatic Blur Affects the Magnitude of Cylindrical-Lens Induced Astigmatism Across the Visual Field in Chickens Open Access

Patience Ansomah Ayerakwah; Byung Soo Kang; Yuanyuan Liang; Henry Ho-lung Chan; Chea-Su Kee; Tsz Wing Leung

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 961. doi:

Combined effects of atropine and myopic defocus against lens induced myopia in the chicks model Open Access

Mezbah Uddin; Rachel Ka-man Chun; King Li; Carly S Y Lam; Chi-ho TO; Dennis Yan-yin Tse

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 962. doi:

In Vivo Optical Recording of Calcium Signals at Mice Corneal Cold Nerve Endings Open Access

Juana Gallar; Fernando Aleixandre-Carrera; Almudena Íñigo-Portugués; M.Carmen Acosta; Victor Meseguer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 963. doi:

Plasmacytoid Dendritic Cell-Derived Secretome Ameliorates Corneal Nerve Dysfunction Open Access

Pedram Hamrah; Brendan Kenyon; Fangfang Qiu; Deshea L Harris

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 964. doi:

Neuropathic corneal pain: Clinical manifestations, imaging features, tear neuromediators and proteomic profiles Open Access

Yu-Chi Liu; Chang Liu; Molly Tzu-Yu Lin; Isabelle Xin Yu Lee; Jipson Hon Fai Wong; Lei Zhou; Jodhbir S Mehta; Louis Tong

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 965. doi:

Ocular surface mast cells exacerbate trigeminal ganglion inflammation and hyperalgesia Open Access

WonKyung Cho; Yilin Guan; Aastha Singh; Sharad Mittal; Sunil Chauhan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 966. doi:

NK1R Inhibition: a Novel Ocular Pain Management Strategy Following Mechanical Corneal Injury Open Access

Pier Luigi Surico; Amirreza Naderi; hideaki Someyaka; Aytan Musayeva; Francesca Kahale; Yihe Chen; Reza Dana

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 967. doi:

PM₁₀: Effects of PM₁₀on human corneal epithelium Open Access

Mallika Somayajulu; Farooq SM; Robert Wright; Ahalya Pitchaikannu; Sharon McClellan; Linda D Hazlett

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 968. doi:

YAP1 regulates cell size of limbal BCAM-positive transit amplifying cells. Open Access

Yuzuru Sasamoto; Bruce Ksander; Markus Hermann Frank; Natasha Frank

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 969. doi:

B Lymphocyte-Induced Maturation Protein-1 Regulates Corneal Epithelial Cell Phenotype Open Access

Sean Ashworth; Jessica E. Treisman; Shukti Chakravarti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 970. doi:

Characterization of transit-amplifying cells in human corneal limbus using single cell transcriptomics Open Access

De-Quan Li; Jin-Miao Li; Fang Bian; Xin Chen; Stephen C Pflugfelder

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 971. doi:

Single-cell RNA sequencing reveals divergent fucose metabolism among human limbal cells Open Access

Pablo Argueso; Ashley M. Woodward; Damien Guindolet; Robert M Lavker; Eric E. Gabison

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 972. doi:

Production and limbal lineage commitment of aniridia patient -derived induced pluripotent stem cells Open Access

Tanja Ilmarinen; Meri Vattulainen; Dominique Bremond-Gignac; Daniel Aberdam; Heli Skottman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 973. doi:

The Roles of Extracellular Calcium-Sensing Receptor (CaSR) in Ocular Surface Ion Transport Open Access

Ethan Lindgren; Yien Ming Kuo; Pattareeya Yottasan; Tifany Chu; Matilda F Chan; Alan S. Verkman; Neel Pasricha; Onur Cil

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 974. doi:

Transfer learning for reducing data inequality in health disparities studies. Open Access

TingFang Lee; Gadi Wollstein; Chisom T. Madu; Andrew Wronka; Lei Zheng; Joel S Schuman; Jiyuan Hu

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 975. doi:

Physiology-enhanced transfer learning discovers combinations of intraocular pressure and blood pressure associated with structural biomarkers of glaucoma eyes in a population-based study Open Access

Giovanna Guidoboni; Daphne Zou; Christopher Wikle; James Keller; Gal Antman; Brent A Siesky; Alice Verticchio; Fotis Topouzis; Alon Harris

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 976. doi:

Noise-PU Learning: Weakly Supervised Time Series Learning to Detect Glaucoma Progression from Optical Coherence Tomography B-scans Open Access

Sayan Mandal; Alessandro A Jammal; Felipe A Medeiros

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 977. doi:

Predicting Visual Field Worsening with Longitudinal Optical Coherence Tomography Data Using a Gated Transformer Network Open Access

Kaihua Hou; Chris Bradley; Patrick Herbert; Chris A Johnson; Michael Wall; Pradeep Y Ramulu; Mathias Unberath; Jithin Yohannan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 978. doi:

Contributions of the inner retina and brain metabolites to glaucoma using information gain assessment Open Access

Jeremy Li; Ji Won Bang; Carlos Parra; Jeannie M. Au; Gadi Wollstein; Joel S Schuman; Kevin C. Chan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 979. doi:

Genome wide discovery via feature space mapping of deep-learning derived clinical OCT phenotypes to the UK biobank Open Access

Nazlee Zebardast; Saber Kazeminasab Hashemabad; Yan Zhao; Sayuri Sekimitsu; Kanza Aziz; Mohammad Eslami; Mengyu Wang; Tobias Elze; Janey L Wiggs

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 980. doi:

Artificial intelligence characterization of central visual field patterns in distinct glaucomatous optic disc phenotypes Open Access

Kelvin Du; Alireza Kamalipour; Sasan Moghimi; Pooya Khosravi; Takashi Nishida; Cristiana Vasile; Kareem Latif; Jeffrey M Liebmann; Massimo A Fazio; Christopher A Girkin; Christopher Bowd; Linda M Zangwill; Tara Javidi; Robert N Weinreb

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 981. doi:

Cost-effectiveness of screening for hydroxychloroquine retinopathy – optimization of the guideline Open Access

Freekje van Asten; Sara W. Quist; Sophie te Dorsthorst; Roel D. Freriks; Maarten J. Postma; Carel C B Hoyng

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 982. doi:

Retinal layer thickness and cognitive impairment: the Beijing Eye Study 2011 Open Access

Zihan Li; Zhe Pan; Jost B. Jonas; Ya Xing Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 983. doi:

Treatment response to avacincaptad pegol by baseline patient characteristics: A prespecified subgroup analysis of the phase 3 GATHER2 study Open Access

Carl J Danzig; Peter Kaiser; David Lally; Glenn J Jaffe; Arshad M. Khanani; Charles Clifton Wykoff; Jeffrey S Heier; Justin Tang; Liansheng Zhu; Julie Clark

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 984. doi:

Anti-VEGF Treatment in Pseudoxanthoma Elasticum – Risk factors and Visual Outcome Open Access

Kristin Raming; Maximilian Pfau; Philipp Herrmann; Frank G Holz; Kristina Pfau

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 985. doi:

Assessment of geographic atrophy (GA) lesion progression in the phase 3 OAKS and DERBY trials Open Access

Allen Chiang; Caleb Bliss; Ramiro Ribeiro

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 986. doi:

Functional benefits of subretinal gene augmentation therapy with Voretigene Neparvovec for inherited retinal disease associated with biallelic mutations in RPE65 Open Access

Birgit Lorenz; Markus N Preising; Johanna Pauline Scholz; Sandrine H. Künzel; Philipp Herrmann; Frank G Holz

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 987. doi:

Football-Related Concussions and Head Impacts Correlate with Structural Changes in the Macula and Optic Nerve Open Access

Rajeev S Ramchandran; Jason Atlas; Mia Young; Lyvia Bertolace; Iwona Juskiewicz; Yonaton Abrham; Kian Merchant-Borna; Sarah Dermady; Brian Keane; Jeffrey Bazarian; Steven Silverstein

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 988. doi:

Systemic uric acid elevation in experimental diabetic retinopathy is associated with pro-inflammatory and pro-fibrotic miR signatures Open Access

Sarah Ye; Sheila Ngumbi; Menaka Thounaojam; Manuela Bartoli

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 989. doi:

O-GlcNAcylation of YAP/TAZ governs pathological angiogenesis in diabetic retinopathy Open Access

Yi Lei; Hua Yan; Xiaohong Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 990. doi:

ALPHA-1 ANTITRYPSIN INCREASES EXPRESSION OF PROTEINS INVOLVED IN NPD1 SYNTHESIS OF CELLS EXPOSED TO HIGH GLUCOSE Open Access

Juan E Gallo; Luciano Magurno; Valentina De Caso Ward; Romina Mouriño; Nicolas G Bazan; MARÍA CONSTANZA POTILINSKI

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 992. doi:

Diabetes renders photoreceptors susceptible to ischemia-reperfusion injury Open Access

Steven F Abcouwer; Cheng-mao Lin; Heather Hager; Sumathi Shanmugam; Alyssa Dreffs; David A Antonetti

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 993. doi:

Vitamin C contributes to epigenetic regulation of genes related to diabetic retinopathy in retinal endothelial cells Open Access

Walker Kay; Jonathon Reynolds; Elizabeth Turner; Marianne Becnel; Gaofeng Wang; David Sant

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 995. doi:

Aquaporin4 expression on ARPE-19 cells exposed to high glucose and Alpha-1 Antitrypsin Open Access

MARÍA CONSTANZA POTILINSKI; Luciano Magurno; Valentina De Caso Ward; Romina Mouriño; Juan E Gallo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 996. doi:

Exploiting retinal endothelial heterogeneity for disease-targeted therapy of diabetic retinopathy Open Access

Prabuddha Waduge; Liyang Ji; Yan Wu; Chengchi Huang; Avinash Kaur; Paola Oliveira; Hong Tian; Jinsong Zhang; J. Timothy Stout; Christina Weng; Keith A Webster; Wei Li

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 997. doi:

Gene therapeutic enhancement of acrolein detoxification mechanisms for the treatment of diabetic retinopathy Open Access

Burak Mugdat Karan; Josy Augustine; Peter Barabas; Mei Chen; Alan W Stitt; Tim M Curtis

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 998. doi:

Roles of oxidative stress in the improvement of retinal blood flow dysregulation by novel therapeutic agents in type 2 diabetic mice Open Access

junya Hanaguri; Ruri Sugiyama; Harumasa Yokota; Akifumi Kushiyama; Sakura Kushiyama; Akira Ohno; Koyo Takase; Satoru Yamagami; Taiji Nagaoka; Seiyo Harino

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 999. doi:

Investigating the role of Glut1 in rod photoreceptors on the development of diabetic retinopathy Open Access

Ivy S Samuels; Aditi S. Priyadershi; Chloe E. Relf; Dana M. Kleinman; Gulnur Bora; Mason A. King; Craig Beight

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1000. doi:

Targetting the Transient Receptor Potential Channels for Restoration of Microvascular Barrier Function in Diabetic Macular Edema. Open Access

Adam Gordon Rollo; Peter Barabas; Josy Augustine; SANAA TARBAN; David Simpson; Tim Curtis

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1001. doi:

Long-term Treatment with MDL 72527 Reduced Retinal Neuro-glial Injury and Improved Visual Acuity, Contrast Sensitivity, and Inner Retinal Function in Diabetic Mice Open Access

Moaddey Alfarhan; Fang Liu; Yini Liao; Payaningal R Somanath; S. Priya Narayanan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1002. doi:

Long noncoding RNAs (LncRNAs) and the metabolic memory associated with the continued progression of diabetic retinopathy Open Access

Jay Kumar; Ghulam Mohammad; Kumari Alka; Renu A. Kowluru

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1003. doi:

The Therapeutic Impact of CBD (Cannabidiol) in Hyperglycemic Zebrafish Open Access

Elizabeth McCarthy; Victoria P Connaughton

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1004. doi:

Long-term Administration with Low Dose Rapamycin Improves Retinal Function in a Mouse Model of Early Diabetic Retinopathy Open Access

Yipin Wang; Ka Cheung Tam; Tsz Chung Ng; Wei Wang; Wai Ching Lam; Amy CY Lo

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1005. doi:

Sitagliptin, a drug for type 2 diabetes, significantly inhibits the pro-inflammatory microglia reactivity Open Access

António Francisco Ambrósio; Sandra Correia; Lucia Bufano; Cristiana Leote; Raquel Boia; Ana Raquel Santiago; Rosa Fernandes; Hélène Léger

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1006. doi:

Nr1d1 protects Endothelial Cells against high glucose- and hypoxia-induced injury by promoting autophagy in diabetic retinopathy Open Access

Suna Ye; Jiansu Chen; Shibo Tang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1007. doi:

PPARα regulates monocyte activation through interaction with the cGAS-STING pathway Open Access

Jian-Xing (Jay) Ma; lijie Dong; Xiang Ma; Wentao Liang; Yusuke Takahashi; Xiao-min Zhang; Xiaorong Li; Rui Cheng

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1008. doi:

Aqueous Humor Neurofilament Light Chain is a Marker of Neurodegeneration in Glaucoma Open Access

Jonathan B Lin; Kristen Pitts; Cameron Neeson; Nathan Eli Hall; Henisk Falah; Hani El Helwe; Silas Wang; Kristine Lo; Christian Song; Milica Margeta; David Sola-Del Valle

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1009. doi:

Caspase-8/cFLIP Interaction in the Regulation of Neuroinflammation in Glaucoma Open Access

Gulgun Tezel; Xiangjun Yang; Qun Zeng; Chyuan-Sheng Lin

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1010. doi:

Optic nerve head astrocyte-specific transcriptional response to chronic elevations of intraocular pressure Open Access

Arpan Guha Mazumder; Amélie M Julé; Daniel Sun

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1011. doi:

Toll-Like Receptor 4 Dependent Glaucomatous Retinal and Optic Nerve Head Damage Open Access

Emma Geiduschek; Timur Mavlyutov; Colleen M McDowell

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1012. doi:

Caveolin-1 and CCN2/CTGF interplay in optic nerve astrocyte reactivity Open Access

Andrea E. Dillinger; Anna Dlugosch; Michael H Elliott; Rudolf Fuchshofer

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1013. doi:

Immunohistochemical grading of human glaucomatous eye globes to ascertain disease severity and correlation with glial reactivity Open Access

Chuanxi Xiang; Manisha Mehta; Yubin Qiu; Christopher W. Wilson; Ganesh Prasanna

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1014. doi:

Retinal ganglion cells suffer mitophagy defects with glaucomatous Optineurin-E50K mutation Open Access

Kavitha Anbarasu; Michelle Surma; Kang-Chieh Huang; Jason S. Meyer; Arupratan Das

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1015. doi:

Ketogenic Diet Increases Mitophagy in a Mouse Model of Glaucoma Open Access

Autumn Morgan; Yan Fan; Denise M Inman

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1016. doi:

Development of a new mitochondrial analysis methodology to elucidate the role of optineurin in glaucoma Open Access

Jenny Yishan Wu; Yu-Min Chung; Henry Tseng

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1017. doi:

Inflammasome activation exacerbates ganglion cell dysfunction and loss in ocular hypertension/glaucoma. Open Access

Markus Spurlock; Weijun An; Galina Reshetnikova; Tsung-Han Chou; Michelle Braha; Gabriela Solis; Juan Pablo De Rivero Vaccary; Galina Dvoriantchikova; Vittorio Porciatti; Valery Shestopalov

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1018. doi:

TRPV4 expression in the healthy and glaucomatous mouse retina Open Access

Denisa Kirdajova; Monika Lakk; Felix Vazquez-Chona; David Krizaj

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1019. doi:

HPS27 induced glaucomatous damage in young and aged mice Open Access

Stephanie C Joachim; Clivia Erb; Carsten Theiss; Nina Schonhoven; H B Dick; Sabrina Reinehr

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1020. doi:

Characterizing single RGC function in models of optic nerve damage Open Access

Delaney Henderson; Johnny Di Pierdomenico; Michele L Hooper; Balwantray C Chauhan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1021. doi:

Retinal ganglion cell death in experimental aldosterone hypertension rat model Open Access

Hiromitsu Onoe; Kazuyuki Hirooka; Yoshiaki Kiuchi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1022. doi:

Variability in Posterior Laminar Surface segmentation and colocalization does not affect the detection of significant increases in retrolaminar Myelin Onset Distance in Non-Human Primate ... Open Access

Priya Chaudhary; Howard Lockwood; Cheri Stowell; Juan Reynaud; Hongli Yang; Stuart Keith Gardiner; Galen Williams; Eric Bushong; Mark Ellisman; Nicholas Marsh-Armstrong; Claude Burgoyne

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1023. doi:

Use of confocal microscopy to measure peripapillary RNFL thickness (ex vivo) in a rat optic nerve transection model Open Access

Yangfeng Li; Toan Phan; Chad E Bigelow; Ganesh Prasanna; Bing Li

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1024. doi:

Longitudinal Peripapillary Atrophy Area Changes Measured with OCT as an Indicator of Glaucoma Progression. Open Access

Maroun Khreish; Gadi Wollstein; TingFang Lee; Zeinab Ghassabi; Ronald Zambrano; Jiyuan Hu; Hiroshi Ishikawa; Joel S Schuman; Fabio Lavinsky

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1025. doi:

The effect of simulated intraocular pressure (IOP) elevation on biomechanical properties and morphology of retinal ganglion cells (RGCs) Open Access

Qinyu Li; Yau Kei Chan; Chinmoy Saha; Heather Kayew Mak; Christopher Kai-Shun Leung

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1026. doi:

Exploring the use of forward genetics to search for novel genetic associations to glaucoma Open Access

Bogale Aredo; Dogan Can Kirman; Yeshumenesh Zegeye; Emily Turpin; Sara Ludwig; Bo Chen; Yi Ding; Eva Marie Moresco; Bruce Beutler; Rafael Ufret-Vincenty

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1027. doi:

Glaucoma is accompanied by reduction of GABA and degraded neural specificity in the visual cortex. Open Access

Ji Won Bang; Carlos Parra; Kevin Yu; Gadi Wollstein; Joel S Schuman; Kevin C. Chan

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1028. doi:

Association between skin carotenoid levels and cognitive impairment screened by Mini-Cog in patients with glaucoma Open Access

Yuji Takayanagi; Junichi Sasaki; Yoichi Kadoh; Akira Obana; Masaki Tanito

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1029. doi:

Quantitative perfusion analysis using contrast-enhanced ultrasound for benign and malignant choroidal tumor Open Access

Vishal Raval; Jayashree Karmarkar; Karla P. Mercado-Shekhar; Himanshu Shekhar; Arun Singh

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1030. doi:

High-speed adaptive optics multi-detection mode ophthalmoscope using a digital micromirror device Open Access

Soohyun Lee; Stacey Choi; Ratheesh Kumar Meleppat; Robert J Zawadzki; Nathan Doble

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1031. doi:

Substrip-based Registration and Automatic Montaging of Adaptive Optics Retinal Images Open Access

Ruixue Liu; Xiaolin Wang; Sujin Hoshi; Yuhua Zhang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1032. doi:

Dense optical flow enables fast acquisution and processing of large panorama AOSLO images Open Access

Jeremy Rogers; Samantha Shrum; Nickie Stangel; Vasu Rishi

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1033. doi:

Assessing adaptive optics scanning light ophthalmoscopy (AOSLO) image quality using a model eye phantom Open Access

Joseph Kreis; Jessica Wong; Robert F Cooper; Mina Gaffney; Jeremy Rogers; Daniel X Hammer; Jacque L Duncan; Joseph Carroll; Anant Agrawal

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1034. doi:

Surpassing the diffraction limit for improved resolution in adaptive optics optical coherence tomography in the living human eye Open Access

Andrew J. Bower; Furu Zhang; Tao Liu; Bartlomiej Kowalski; Rongwen Lu; Zhuolin Liu; Daniel X Hammer; Alfredo Dubra; Johnny Tam

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1035. doi:

First-in-human simultaneous multiwavelength ultra-widefield (MW-UWF) fundus fluorescein (FFA) and indocyanine green (ICG) angiography with navigated central and peripheral swept-source op... Open Access

Francisco Javier Javier Valentín Bravo; William Ayliffe; Sebastian Eduardo Francis Stanga; Ursula Inge Reinstein; Rob Moxham; Zeb Tariq; Susan M Downes; Paulo-Eduardo Stanga

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1036. doi:

Facial angiosomes obtained by camera-based imaging photoplethysmography correlate with choroidal volume measurements by OCT Open Access

Qinghua He; Yi Zhang; Mengxi Shen; Giovanni Gregori; Philip J Rosenfeld; Ruikang K Wang

Investigative Ophthalmology & Visual Science June 2023, Vol.64, 1037. doi:

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