Volume 64 Issue 10 | IOVS

Anatomy and Pathology/Oncology

CD63/81 Small Extracellular Vesicles in the Aqueous Humor are Retinoblastoma Associated Open Access

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Sarah Pike; Chen-Ching Peng; Paolo Neviani; Jesse L. Berry; Liya Xu

Tags: aqueous humor, cd63 antigen, extracellular vesicles, eye, hypertension

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 5. doi:https://doi.org/10.1167/iovs.64.10.5

Molecular, Cellular, and Functional Heterogeneity of Retinal and Choroidal Endothelial Cells Open Access

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Soo Jin Kim; Joon Seo Lim; Jun Hyeong Park; Junyeop Lee

Tags: choroid, electroconvulsive therapy, endothelial cells, endothelium, epidural cortical stimulation

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 35. doi:https://doi.org/10.1167/iovs.64.10.35

Biochemistry and Molecular Biology

Regulation of Long Noncoding RNA NEAT1/miR-320a/HIF-1α Competitive Endogenous RNA Regulatory Network in Diabetic Retinopathy Open Access

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Xiaodan Zhu; Yan Wang; Lei Cheng; Hongyu Kuang

Tags: angiopoietin-like 4 protein, diabetic retinopathy, permeability, polymerase chain reaction, regulation

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 11. doi:https://doi.org/10.1167/iovs.64.10.11

Human Lacrimal Gland Derived Mesenchymal Stem Cells – Isolation, Propagation, and Characterization Open Access

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Jilu Jaffet; Aparna Mohanty; Induvahi Veernala; Swati Singh; Mohammad Javed Ali; Sayan Basu; Geeta K. Vemuganti; Vivek Singh

Tags: lacrimal gland, langer-giedion syndrome, mesenchymal stem cells, patient isolation, social isolation

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 12. doi:https://doi.org/10.1167/iovs.64.10.12

Clinical and Epidemiologic Research

Alcohol Consumption, Genetic Risk, and Intraocular Pressure and Glaucoma: The Canadian Longitudinal Study on Aging Open Access

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Alyssa Grant; Marie-Hélène Roy-Gagnon; Joseph Bastasic; Akshay Talekar; Mahsa Jessri; Gisele Li; Ralf Buhrmann; Ellen E. Freeman

Tags: alcohol drinking, ethanol, genetic risk, glaucoma, intraocular pressure

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 3. doi:https://doi.org/10.1167/iovs.64.10.3

Conditional Metastasis of Uveal Melanoma in 8091 Patients over Half-Century (51 Years) by Age Group: Assessing the Entire Population and the Extremes of Age Open Access

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Carol L. Shields; Annika G. Samuelson; Glenn J. Oh; Joseph D. DeSimone; Zaynab L. Sajjadi; Zeynep Bas; Nicholas E. Kalafatis; Sara E. Lally; Jerry A. Shields; Philip W. Dockery

Tags: neoplasm metastasis, uveal melanoma

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 7. doi:https://doi.org/10.1167/iovs.64.10.7

Prevalence, Concordance, and Heritability of Vitreomacular Interface Abnormalities in a Twin Study Open Access

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Zakariya A. Jarrar; Abdus Samad Ansari; Katie M. Williams; Dominic S. Wong; Pirro G. Hysi; Omar A. Mahroo; Christopher J. Hammond

Tags: prevalence, spectral domain-optical coherence tomography, twin studies

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 9. doi:https://doi.org/10.1167/iovs.64.10.9

Diabetes-Related Risk Factors for Exudative Age-Related Macular Degeneration: A Nationwide Cohort Study of a Diabetic Population Open Access

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Sungsoon Hwang; Se Woong Kang; Sang Jin Kim; Kyu Na Lee; Kyungdo Han; Dong Hui Lim

Tags: cohort studies, diabetes mellitus, diabetes mellitus, type 2, exudative age-related macular degeneration, risk factors

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 10. doi:https://doi.org/10.1167/iovs.64.10.10

Air Pollution and Meteorological Conditions Significantly Associated With Vernal Keratoconjunctivitis Exacerbations Open Access

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Eran Levanon; Ido Peles; Michal Gordon; Lena Novack; Erez Tsumi

Tags: air pollution, keratoconjunctivitis, vernal, environmental factors

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 37. doi:https://doi.org/10.1167/iovs.64.10.37

Cornea

Obstruction of the Tear Drainage Altered Lacrimal Gland Structure and Function Open Access

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Bing Xiao; Dianlei Guo; Ren Liu; Mengqian Tu; Ziyan Chen; Yingfeng Zheng; Chunqiao Liu; Lingyi Liang

Tags: lacrimal duct, lacrimal gland, mice, ocular surfaces, proteins

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 13. doi:https://doi.org/10.1167/iovs.64.10.13

Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis Open Access

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Saumya Nagar; Layla Ajouz; Kelly K. Nichols; Sandeep Kumar; Cathy Zhao; Kugen K. Naidoo; Michael R. Robinson; Douglas Borchman

Tags: lipids, meibomian gland dysfunction

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 22. doi:https://doi.org/10.1167/iovs.64.10.22

Corneal Biomechanical Properties Demonstrate Anisotropy and Correlate With Axial Length in Myopic Eyes Open Access

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Lingfeng Chen; Yangyi Huang; Xiaoyu Zhang; Yike Shi; Zhipeng Gao; Bingqing Sun; Yang Shen; Ling Sun; Yifan Cao; Qianqian Zhang; Jiqiang Guo; Fen Li; Weiyi Chen; Xiaona Li; Xingtao Zhou

Tags: cornea, eye, anisotropy, stress

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 27. doi:https://doi.org/10.1167/iovs.64.10.27

Genetics

Association of Behavioral and Clinical Risk Factors With Cataract: A Two-Sample Mendelian Randomization Study Open Access

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Chen Jiang; Ronald B. Melles; Poorab Sangani; Thomas J. Hoffmann; Pirro G. Hysi; M. Maria Glymour; Eric Jorgenson; Salil A. Lachke; Hélène Choquet

Tags: cataract, genetics, risk factors, open-angle glaucoma, mendelian randomization analysis

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 19. doi:https://doi.org/10.1167/iovs.64.10.19

Usher Syndrome on the Island of Ireland: A Genotype-Phenotype Review Open Access

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Kirk A. J. Stephenson; Laura Whelan; Julia Zhu; Adrian Dockery; Niamh C. Wynne; Rebecca M. Cairns; Claire Kirk; Jacqueline Turner; Emma S. Duignan; James J. O'Byrne; Giuliana Silvestri; Paul F. Kenna; G. Jane Farrar; David J. Keegan

Tags: genetics, genotype, ireland, phenotype, usher syndrome

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 23. doi:https://doi.org/10.1167/iovs.64.10.23

Genotype Impacts Axial Length Growth in Pseudophakic Eyes of Marfan Syndrome Open Access

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Ze-Xu Chen; Wan-Nan Jia; Tian-Hui Chen; Jia-Hao Hong; Yang Sun; Yan Liu; Ling-Hao Song; Yong-Xiang Jiang

Tags: eye, fibrillin-1, genotype, marfan syndrome, pseudophakia

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 28. doi:https://doi.org/10.1167/iovs.64.10.28

Glaucoma

TBK1 Knockdown Alleviates Axonal Transport Deficits in Retinal Ganglion Cells Via mTORC1 Activation in a Retinal Damage Mouse Model Open Access

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Meng Ye; Yuanyuan Hu; Bowen Zhao; Qianxue Mou; Yueqi Ni; Jing Luo; Lu Li; Hong Zhang; Yin Zhao

Tags: axonal transport, mechanistic target of rapamycin complex 1, mice, raptors, retinal ganglion cells

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 1. doi:https://doi.org/10.1167/iovs.64.10.1

DPP-4 Inhibitors Attenuate Fibrosis After Glaucoma Filtering Surgery by Suppressing the TGF-β/Smad Signaling Pathway Open Access

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Masaaki Yoshida; Taiki Kokubun; Kota Sato; Satoru Tsuda; Yu Yokoyama; Noriko Himori; Toru Nakazawa

Tags: attenuation, blister, dipeptidyl-peptidase iv inhibitors, fibrosis, filtering surgery

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 2. doi:https://doi.org/10.1167/iovs.64.10.2

Optic Nerve Head Gene Transcription Sequelae to a Single Elevated IOP Exposure Provides Insights Into Known Responses to Chronically Elevated IOP Open Access

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Diana C. Lozano; Hari Jayaram; William O. Cepurna; Shandiz Tehrani; Lina Gao; Suzanne S. Fei; Dongseok Choi; Elaine C. Johnson; John C. Morrison

Tags: genes, optic disk, raised intraocular pressure, gene expression, intraocular pressure

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 4. doi:https://doi.org/10.1167/iovs.64.10.4

Aqueous Humor TGF-β2 and Its Association With Intraocular Pressure in a Naturally Occurring Large Animal Model of Glaucoma Open Access

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Kazuya Oikawa; Odalys Torne; David Sun; Alaina K. B. Moon; Julie A. Kiland; Ralph Møller Trane; Gillian J. McLellan

Tags: animal model, cats, glaucoma, hypertension, intraocular pressure

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 18. doi:https://doi.org/10.1167/iovs.64.10.18

Immunology and Microbiology

Phylogenetic and Genomic Characterization of Whole Genome Sequences of Ocular Herpes Simplex Virus Type 1 Isolates Identifies Possible Virulence Determinants in Humans Open Access

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Viet Q. Chau; Aaron W. Kolb; Darlene L. Miller; Nicolas A. Yannuzzi; Curtis R. Brandt

Tags: eye infection herpes simplex, genome, human herpesvirus 1, single nucleotide polymorphism, virulence

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 16. doi:https://doi.org/10.1167/iovs.64.10.16

Blocking Th2 Signaling Pathway Alleviates the Clinical Symptoms and Inflammation in Allergic Conjunctivitis Open Access

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Zhiyan Tao; Wei Liu; Qin Chen; Libo Zhang; Kaiqin She; Guoqing Zhao; Licong Liang; Xuhong Chen; Yiliu Yang; Qin Song; Fang Lu

Tags: allergic conjunctivitis, inflammation, interleukin-13, interleukin-4, signal pathway

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 30. doi:https://doi.org/10.1167/iovs.64.10.30

Lens

ErbBs in Lens Cell Fibrosis and Secondary Cataract Open Access

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Judy K. VanSlyke; Bruce A. Boswell; Linda S. Musil

Tags: epidermal growth factor receptors, erbb4 gene, fibrosis, lapatinib, lens cell

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 6. doi:https://doi.org/10.1167/iovs.64.10.6

Multidisciplinary Ophthalmic Imaging

The Changes in Ocular Biomechanical Response Parameters and Intraocular Pressure After Surgical Treatment for Thyroid Eye Disease Open Access

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Yun Hsia; Yi-Hsuan Wei; Shu-Lang Liao

Tags: biomechanics, graves' ophthalmopathy, intraocular pressure, orbital decompression, surgical procedures, operative

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 31. doi:https://doi.org/10.1167/iovs.64.10.31

Retina

Flow Heterogeneity and Factors Contributing to the Variability in Retinal Capillary Blood Flow Open Access

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Srividya Neriyanuri; Phillip Bedggood; R. C. Andrew Symons; Andrew B. Metha

Tags: blood capillaries, fluid flow, heterogeneity

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 15. doi:https://doi.org/10.1167/iovs.64.10.15

Enhanced S-Cone Syndrome: Elevated Cone Counts Confer Supernormal Visual Acuity in the S-Cone Pathway Open Access

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Yiyi Wang; Jessica Wong; Jacque L. Duncan; Austin Roorda; William S. Tuten

Tags: enhanced s-cone syndrome, retinal cone, visual acuity

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 17. doi:https://doi.org/10.1167/iovs.64.10.17

Relative Ellipsoid Zone Reflectivity in Macular Telangiectasia Type 2 Open Access

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Lukas Goerdt; Leonie Weinhold; Ben Isselmann; Jose Luis Rodriguez Garcia; Sandrine H. Künzel; Matthias Schmid; Frank G. Holz; Simone Tzaridis; Sarah Thiele

Tags: eye, telangiectasis, spectral domain-optical coherence tomography

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 21. doi:https://doi.org/10.1167/iovs.64.10.21

AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model Open Access

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Daniel Grigsby; Mikael Klingeborn; Una Kelly; Lindsey A. Chew; Aravind Asokan; Garth Devlin; Sharon Smith; Lisa Keyes; Adrian Timmers; Abraham Scaria; Catherine Bowes Rickman

Tags: complement factor h, complement system proteins, follicular bronchiolitis, foreign bodies, genes

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 25. doi:https://doi.org/10.1167/iovs.64.10.25

Aqueous Fluid Transcriptome Profiling Differentiates Between Non-Neovascular and Neovascular AMD Open Access

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Georgia Kaidonis; Ricardo Lamy; Joshua Wu; Daphne Yang; Catherine Psaras; Thuy Doan; Jay M. Stewart

Tags: exudative age-related macular degeneration, eye, transcription, genetic, genes

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 26. doi:https://doi.org/10.1167/iovs.64.10.26

Visual Function and Inner Retinal Structure in Relation to Birth Factors in Autosomal Dominant Optic Atrophy Open Access

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Christina Eckmann-Hansen; Toke Bek; Birgit Sander; Michael Larsen

Tags: birth, optic atrophy, autosomal dominant, perinatal period, retina, vision

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 32. doi:https://doi.org/10.1167/iovs.64.10.32

Cone Photoreceptor Morphology in Choroideremia Assessed Using Non-Confocal Split-Detection Adaptive Optics Scanning Light Ophthalmoscopy Open Access

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Peiluo Xu; Yu You Jiang; Jessica I. W. Morgan

Tags: language morphology, morphology, optics, retinal cone, choroideremia

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 36. doi:https://doi.org/10.1167/iovs.64.10.36

Retinal Cell Biology

Phosphorylation of αB-Crystallin Involves Interleukin-1β-Mediated Intracellular Retention in Retinal Müller Cells: A New Mechanism Underlying Fibrovascular Membrane Formation Open Access

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Taku Yamamoto; Satoru Kase; Akihiro Shinkai; Miyuki Murata; Kasumi Kikuchi; Di Wu; Yasushi Kageyama; Masami Shinohara; Tomohiko Sasase; Susumu Ishida

Tags: crystallins, tissue membrane, phosphorylation, interleukins, alpha-crystallin b chain

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 20. doi:https://doi.org/10.1167/iovs.64.10.20

Visual Neuroscience

mTORC1 Signaling and Negative Lens-Induced Axial Elongation Open Access

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Ruiheng Zhang; Li Dong; Haotian Wu; Xuhan Shi; Wenda Zhou; Heyan Li; Yitong Li; Chuyao Yu; Yifan Li; Yao Nie; Lei Shao; Chuan Zhang; Yueming Liu; Jost B. Jonas; Wenbin Wei; Qiong Yang

Tags: lens (device), lens, crystalline, mechanistic target of rapamycin complex 1, signal transduction, caviidae

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 24. doi:https://doi.org/10.1167/iovs.64.10.24

Review

The Role of Müller Cells in Diabetic Macular Edema Open Access

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Dongwei Lai; Yang Wu; Chuhan Shao; Qinghua Qiu

Tags: diabetes mellitus, diabetic macular edema, gene therapy, glucose, hyperglycemia

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 8. doi:https://doi.org/10.1167/iovs.64.10.8

Determining a Worldwide Prevalence of Oculocutaneous Albinism: A Systematic Review Open Access

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Jennifer G. R. Kromberg; Kaitlyn A. Flynn; Robyn A. Kerr

Tags: albinism, albinism, oculocutaneous, prevalence, systematic reviews

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 14. doi:https://doi.org/10.1167/iovs.64.10.14

Clinical Applications of Machine Learning in the Management of Intraocular Cancers: A Narrative Review Open Access

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Anirudha S. Chandrabhatla; Taylor M. Horgan; Caroline C. Cotton; Naveen K. Ambati; Yevgeniy Eugene Shildkrot

Tags: cancer, machine learning, narrative review, eye cancer

Investigative Ophthalmology & Visual Science July 2023, Vol.64, 29. doi:https://doi.org/10.1167/iovs.64.10.29

Erratum

Erratum in: Editorial: International Myopia Institute White Paper Series 2023 Open Access

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Investigative Ophthalmology & Visual Science July 2023, Vol.64, 33. doi:https://doi.org/10.1167/iovs.64.10.33

Erratum in: IMI 2023 Digest Open Access

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Investigative Ophthalmology & Visual Science July 2023, Vol.64, 34. doi:https://doi.org/10.1167/iovs.64.10.34

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