Volume 64 Issue 12 | IOVS

Anatomy and Pathology/Oncology

Mechanisms of Extraorbital Lacrimal Gland Aging in Mice: An Integrative Analysis of the Temporal Transcriptome Open Access

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Jiangman Liu; Hongli Si; Duliurui Huang; Dingli Lu; Sen Zou; Di Qi; Xiaoting Pei; Shenzhen Huang; Zhijie Li

Tags: aging, mice, lacrimal gland

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 18. doi:https://doi.org/10.1167/iovs.64.12.18

Biochemistry and Molecular Biology

Kallistatin Deficiency Induces the Oxidative Stress-Related Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells: A Novel Protagonist in Age-Related Macular Degeneration Open Access

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Gang Shen; Yanmei Li; Yongcheng Zeng; Fuyan Hong; Jing Zhang; Yan Wang; Chengwei Zhang; Wei Xiang; Jinhong Wang; Zhenzhen Fang; Weiwei Qi; Xia Yang; Guoquan Gao; Ti Zhou

Tags: age-related macular degeneration, epithelial to mesenchymal transition, retinal pigment cell, stress, oxidative stress

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 15. doi:https://doi.org/10.1167/iovs.64.12.15

Clinical and Epidemiologic Research

Longitudinal Changes in Axial Length and Spherical Equivalent in Children and Adolescents With High Myopia Open Access

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Feng Jiang; Decai Wang; Qiuxia Yin; Mingguang He; Zhixi Li

Tags: adolescent, child, myopia

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 6. doi:https://doi.org/10.1167/iovs.64.12.6

The Association of Antibiotic Use and the Odds of a New-Onset ICD Code Diagnosis of Age-Related Macular Degeneration: A Large National Case-Control Study Open Access

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John Moir; Max Hyman; Jessie Wang; Andrea Flores; Dimitra Skondra

Tags: antibiotics, age-related macular degeneration

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 14. doi:https://doi.org/10.1167/iovs.64.12.14

Comparison of Ophthalmic Artery Morphological Characteristics and Retinal Vessel Diameter for Identifying Ocular Ischemic Syndrome Open Access

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Xue-ru Cheng; Lu Zhao; Ying-xiang Huang; Yan-ling Wang; Jia-lin Wang

Tags: language morphology, morphology, ophthalmic artery, retinal ischemia, retinal vessels

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 20. doi:https://doi.org/10.1167/iovs.64.12.20

Genetic Risk Score Analysis Supports a Joint View of Two Classification Systems for Age-Related Macular Degeneration Open Access

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Janina M. Herold; Martina E. Zimmermann; Mathias Gorski; Felix Günther; Bernhard H. F. Weber; Horst Helbig; Klaus J. Stark; Iris M. Heid; Caroline Brandl

Tags: age-related macular degeneration, chief complaint, genetic risk, drusen, genetics

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 31. doi:https://doi.org/10.1167/iovs.64.12.31

Cornea

Association of Ocular Surface Immune Cells With Dry Eye Signs and Symptoms in the Dry Eye Assessment and Management (DREAM) Study Open Access

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Eric J. Kuklinski; Yinxi Yu; Gui-Shuang Ying; Penny A. Asbell; for the DREAM Study Research Group

Tags: dreams, dry eye syndromes, ocular surfaces, signs and symptoms, eye

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 7. doi:https://doi.org/10.1167/iovs.64.12.7

Sympathetic Nerves Coordinate Corneal Epithelial Wound Healing by Controlling the Mobilization of Ly6C^hi Monocytes From the Spleen to the Injured Cornea Open Access

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Siyu He; Jun Liu; Yunxia Xue; Ting Fu; Zhijie Li

Tags: cornea, monocytes, spleen, corneal abrasions, wound healing

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 13. doi:https://doi.org/10.1167/iovs.64.12.13

Bacillus-Derived Manganese Superoxide Dismutase Relieves Ocular-Surface Inflammation and Damage by Reducing Oxidative Stress and Apoptosis in Dry Eye Open Access

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Hyeon-Jeong Yoon; Rujun Jin; Hee Su Yoon; Ji Suk Choi; Yenny Kim; Seung Hyun Pan; Inik Chang; Lan Li; Ying Li; Jonghwa Kim; Kyung Chul Yoon

Tags: apoptosis, bacillus, conjunctiva, cornea, cyclosporine

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 30. doi:https://doi.org/10.1167/iovs.64.12.30

Alteration of Meibum Lipidomics Profiling in Patients With Chronic Ocular Graft-Versus-Host Disease Open Access

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Wenxin Zhao; Jing Yang; Yinglin Liao; Boyu Yang; Shujiao Lin; Ren Liu; Lingyi Liang

Tags: lipids, graft-versus-host disease, lipidomics

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 35. doi:https://doi.org/10.1167/iovs.64.12.35

Isolation and Characterization of Human Conjunctival Mesenchymal Stromal Cells and Their Extracellular Vesicles Open Access

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Laura García-Posadas; Ismael Romero-Castillo; Kieran Brennan; Margaret M. Mc Gee; Alfonso Blanco-Fernández; Yolanda Diebold

Tags: antioxidants, conjunctiva, extracellular vesicles, mesenchymal stem cells, patient isolation

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 38. doi:https://doi.org/10.1167/iovs.64.12.38

Role of Fibroblast Growth Factor Receptor 2 (FGFR2) in Corneal Stromal Thinning Open Access

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Roy Joseph; Akosua Boateng; Om P. Srivastava; Roswell R. Pfister

Tags: cornea, mice, fgfr2 gene, fibroblast growth factor receptors, keratoconus

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 40. doi:https://doi.org/10.1167/iovs.64.12.40

Extracellular Vesicle MicroRNAs From Corneal Stromal Stem Cell Enhance Stemness of Limbal Epithelial Stem Cells by Targeting the Notch Pathway Open Access

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Leying Wang; Xizhan Xu; Qiankun Chen; Yuan Wei; Zhenyu Wei; Zi-Bing Jin; Qingfeng Liang

Tags: cornea, epithelial stem cells, extracellular vesicles, mesenchymal stem cells, micrornas

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 42. doi:https://doi.org/10.1167/iovs.64.12.42

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Peripapillary Vascular Density in Compressive Optic Neuropathy and Normal-Tension Glaucoma: A Severity-Controlled Comparison Open Access

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Eun Jung Lee; Jong Chul Han; Changwon Kee; Kyung-Ah Park; Doo-Sik Kong; Sang Duk Hong

Tags: glaucoma, low tension glaucoma, optic nerve compression, vascular density, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 10. doi:https://doi.org/10.1167/iovs.64.12.10

Nystagmus Associated With the Absence of MYOD Expression Across the Lifespan in Extraocular and Limb Muscles Open Access

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Laura L. Johnson; Sadie Hebert; Rachel B. Kueppers; Linda K. McLoon

Tags: aging, life span, limb, mice, muscle

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 24. doi:https://doi.org/10.1167/iovs.64.12.24

Genetics

Dysregulated Arginine Metabolism Is Linked to Retinal Degeneration in Cep250 Knockout Mice Open Access

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Lue Xiang; Qiao-Li Yang; Bin-Tao Xie; Hui-Yi Zeng; Liu-Jun Ding; Feng-Qin Rao; Tong Yan; Fan Lu; Qi Chen; Xiu-Feng Huang

Tags: arginine, mice, retina, retinal degeneration, metabolism

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 2. doi:https://doi.org/10.1167/iovs.64.12.2

TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal Detachment: A Genome-Wide Association Study and Polygenic Risk Score Analysis Open Access

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Hao-Kai Chuang; Ai-Ru Hsieh; Tien-Yap Ang; Szu-Wen Chen; Yi-Ping Yang; Hung-Juei Huang; Shih-Hwa Chiou; Tai-Chi Lin; Shih-Jen Chen; Chih-Chien Hsu; De-Kuang Hwang

Tags: genetic risk, genome-wide association study, polygenic risk score, polymorphism, retinal detachment

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 17. doi:https://doi.org/10.1167/iovs.64.12.17

RPGR: Deep Phenotyping and Genetic Characterization With Findings Specific to the 3′-end of ORF15 Open Access

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Matthew D. Benson; Souvick Mukherjee; Aime R. Agather; Delphine Blain; Denise Cunningham; Robert Mays; Xun Sun; Tiansen Li; Robert B. Hufnagel; Brian P. Brooks; Laryssa A. Huryn; Wadih M. Zein; Catherine A. Cukras

Tags: phenotype determination, retinal diseases, genetics, dark adaptation, diagnostic imaging

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 19. doi:https://doi.org/10.1167/iovs.64.12.19

Ophthalmologic Phenotype–Genotype Correlations in Patients With Oculocutaneous Albinism Followed in a Reference Center Open Access

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Paul-Henri Seguy; Jean-François Korobelnik; Marie-Noëlle Delyfer; Vincent Michaud; Benoit Arveiler; Eulalie Lasseaux; Sarra Gattoussi; Marie-Bénédicte Rougier; Kilian Trin; Fanny Morice-Picard; Nathalie Ghomashchi; Valentine Coste

Tags: albinism, albinism, oculocutaneous, foveal hypoplasia, genotype, oculocutaneous albinism type 1

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 26. doi:https://doi.org/10.1167/iovs.64.12.26

Comprehensive Genetic Analysis Unraveled the Missing Heritability and a Founder Variant of BEST1 in a Chinese Cohort With Autosomal Recessive Bestrophinopathy Open Access

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Jie Shi; Lu Tian; Tengyang Sun; Xiao Zhang; Ke Xu; Yue Xie; Xiaoyan Peng; Xin Tang; Zi-Bing Jin; Yang Li

Tags: autosomal recessive inheritance, best1 gene, bestrophinopathy, chinese (other dialects), chinese people

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 37. doi:https://doi.org/10.1167/iovs.64.12.37

Glaucoma

Keratin8 Deficiency Aggravates Retinal Ganglion Cell Damage Under Acute Ocular Hypertension Open Access

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Chengshou Zhang; Naiji Yu; Qiyu Qin; Xingdi Wu; Yuxiang Gu; Tong Liu; Qi Zhang; Xin Liu; Min Chen; Kaijun Wang

Tags: glaucoma, ocular hypertension, retina, retinal ganglion cells, symptom aggravating factors

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 1. doi:https://doi.org/10.1167/iovs.64.12.1

Relationships of Macular Functional Impairment With Structural and Vascular Changes According to Glaucoma Severity Open Access

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Hye Seong Hwang; Eun Ji Lee; Hyunjoong Kim; Tae-Woo Kim

Tags: functional impairment, glaucoma, macula lutea, open-angle glaucoma

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 5. doi:https://doi.org/10.1167/iovs.64.12.5

Exploring Early-Stage Retinal Neurodegeneration in Murine Pigmentary Glaucoma: Insights From Gene Networks and miRNA Regulation Analyses Open Access

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Qingqing Gu; Aman Kumar; Michael Hook; Fuyi Xu; Akhilesh Kumar Bajpai; Athena Starlard-Davenport; Junming Yue; Monica M. Jablonski; Lu Lu

Tags: genes, mice, micrornas, glaucoma, pigmentary, glaucoma

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 25. doi:https://doi.org/10.1167/iovs.64.12.25

Post-Illumination Pupil Response and Sleep Quality in Patients With Glaucoma: The LIGHT Study Open Access

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Hironobu Jimura; Tadanobu Yoshikawa; Kenji Obayashi; Kimie Miyata; Keigo Saeki; Nahoko Ogata

Tags: glaucoma, pupil reaction, sleep quality, light, sleep disorders

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 34. doi:https://doi.org/10.1167/iovs.64.12.34

Paraventricular Hypothalamic Nucleus Upregulates Intraocular Pressure Via Glutamatergic Neurons Open Access

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Lin Ma; Qing Liu; Xin Liu; Heng Chang; Sen Jin; Wenyu Ma; Fuqiang Xu; Haixia Liu

Tags: intraocular pressure, mice, neurons, regulation, paraventricular nucleus

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 43. doi:https://doi.org/10.1167/iovs.64.12.43

Immunology and Microbiology

Plasma-Derived Small Extracellular Vesicles From VKH Patients Suppress T Cell Proliferation Via MicroRNA-410-3p Modulation of CXCL5 Axis Open Access

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Bing Li; Nan Sun; Fuhua Yang; Kailei Guo; Lingzi Wu; Mingming Ma; Hui Shao; Xiaorong Li; Xiaomin Zhang

Tags: micrornas, plasma, t-lymphocytes, extracellular vesicles

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 11. doi:https://doi.org/10.1167/iovs.64.12.11

Therapeutic Effects of Upadacitinib on Experimental Autoimmune Uveitis: Insights From Single-Cell Analysis Open Access

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Zhaohao Huang; Qi Jiang; Junjie Chen; Xiuxing Liu; Chenyang Gu; Tianyu Tao; Jianjie Lv; Zhaohuai Li; Zuohong Li; Wenru Su

Tags: autoimmunity, mice, upadacitinib, uveitis, cxcr4 receptors

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 28. doi:https://doi.org/10.1167/iovs.64.12.28

Causal Effects of Gut Microbiota on Age-Related Macular Degeneration: A Mendelian Randomization Study Open Access

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Deshen Mao; Borui Tao; Shuyan Sheng; Hui Jin; Wenxuan Chen; Huimin Gao; Jianyi Deng; Zhuo Li; Fan Chen; Shixin Chan; Longqi Qian

Tags: age-related macular degeneration, mendelian randomization analysis, microbiome, sensitivity analysis, single nucleotide polymorphism

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 32. doi:https://doi.org/10.1167/iovs.64.12.32

Low Vision

Dual Sensory Impairment: Impact of Central Vision Loss and Hearing Loss on Visual and Auditory Localization Open Access

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Ying-Zi Xiong; Douglas A. Addleman; Nam Anh Nguyen; Peggy Nelson; Gordon E. Legge

Tags: blindness, hearing, hearing loss, sensory deficit, sound localization

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 23. doi:https://doi.org/10.1167/iovs.64.12.23

Multidisciplinary Ophthalmic Imaging

Choriocapillaris Impairment Is Associated With Delayed Rod-Mediated Dark Adaptation in Age-Related Macular Degeneration Open Access

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Deepayan Kar; Giulia Corradetti; Thomas A. Swain; Mark E. Clark; Gerald McGwin, Jr.; Cynthia Owsley; SriniVas R. Sadda; Christine A. Curcio

Tags: age-related macular degeneration, dark adaptation, drusen, eye, fluid flow

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 41. doi:https://doi.org/10.1167/iovs.64.12.41

Physiology and Pharmacology

Age-Dependent Changes in Regulation of Water Inflow Into the Vitreous Body Open Access

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Satoshi Ueki; Yuji Suzuki; Yukimi Nakamura; Hironaka Igarashi

Tags: aging, regulation, vitreous body, water, eye

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 22. doi:https://doi.org/10.1167/iovs.64.12.22

Retina

Pharmacokinetics of Orbital Topotecan After Ophthalmic Artery Chemosurgery and Intravenous Infusion in the Swine Model Open Access

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Flavio Requejo; Javier Opezzo; Alan Vater; Marcelo Asprea; Eduardo Lagomarsino; Claudia Sampor; Adriana Fandiño; Guillermo Chantada; Jasmine H. Francis; David H. Abramson; Paula Schaiquevich

Tags: intravenous infusion procedures, ophthalmic artery, retinoblastoma, suidae, topotecan

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 3. doi:https://doi.org/10.1167/iovs.64.12.3

Hyperautofluorescent Ring Pattern in Retinitis Pigmentosa: Clinical Implications and Modifications Over Time Open Access

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Alessio Antropoli; Alessandro Arrigo; Lorenzo Bianco; Elena Cavallari; Francesco Bandello; Maurizio Battaglia Parodi

Tags: eye, follow-up, retinitis pigmentosa

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 8. doi:https://doi.org/10.1167/iovs.64.12.8

Choriocapillaris, Photoreceptors, and Inner Retinal Layer in Spatial Relationship to Parapapillary Alpha, Beta, Gamma, and Delta Zones Open Access

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Jost B. Jonas; Rahul A. Jonas; Shefali B. Jonas; Songhomitra Panda-Jonas

Tags: eye, glaucoma, photoreceptors

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 12. doi:https://doi.org/10.1167/iovs.64.12.12

The Clinical Role of the Choroidal Assessment in High Myopia: Characteristics and Association With Neovascular and Atrophic Complications Open Access

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Alessandro Arrigo; Emanuela Aragona; Lorenzo Bianco; Alessio Antropoli; Andrea Saladino; Francesco Bandello; Maurizio Battaglia Parodi

Tags: atrophic condition of skin, macular neovascularization, myopia, eye

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 16. doi:https://doi.org/10.1167/iovs.64.12.16

Study of Foveal Avascular Zone Growth in Individuals With Mild Diabetic Retinopathy by Optical Coherence Tomography Open Access

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Jian Liu; Yang He; Linghui Kong; Dongni Yang; Nan Lu; Yao Yu; Yuqian Zhao; Yi Wang; Zhenhe Ma

Tags: diabetic retinopathy, optical coherence tomography, angiogram

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 21. doi:https://doi.org/10.1167/iovs.64.12.21

Cone Density Distribution and Related Factors in Patients Receiving Hydroxychloroquine Treatment Open Access

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Jun Tang; Hua Liu; Shiyan Mo; Zhihong Zhu; Houbin Huang; Xiaofei Liu

Tags: hydroxychloroquine, retinal cone, rheumatic disorders

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 29. doi:https://doi.org/10.1167/iovs.64.12.29

ABCA4 Variant c.5714+5G>A in Trans With Null Alleles Results in Primary RPE Damage Open Access

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Jana Sajovic; Andrej Meglič; Zelia Corradi; Mubeen Khan; Aleš Maver; Martina Jarc Vidmar; Marko Hawlina; Frans P. M. Cremers; Ana Fakin

Tags: abca4 gene, alleles, photoreceptors

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 33. doi:https://doi.org/10.1167/iovs.64.12.33

Dasatinib Plus Quercetin Alleviates Choroid Neovascularization by Reducing the Cellular Senescence Burden in the RPE–Choroid Open Access

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Yinhao Wang; Yulin Tseng; Keyu Chen; Kuangqi Chen; Kai Chen; Zhihua Huang; Zebin Mao; Xuemin Li

Tags: aging, choroid, choroidal neovascularization, older adult, cellular senescence

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 39. doi:https://doi.org/10.1167/iovs.64.12.39

Choroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen Open Access

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Yevgeniy Sazhnyev; Tzu-Ni Sin; Anthony Ma; Ellie Chang; Leon Huynh; Karolina Roszak; Sangwan Park; Kevin Choy; Sina Farsiu; Ala Moshiri; Sara M. Thomasy; Glenn Yiu

Tags: aging, drusen, macaca mulatta

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 44. doi:https://doi.org/10.1167/iovs.64.12.44

Visual Neuroscience

The Neuroprotective Effect of Activation of Sigma-1 Receptor on Neural Injury by Optic Nerve Crush Open Access

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Yao Chen; Xueli Yang; Junfeng Mao

Tags: brain-derived neurotrophic factor, in situ nick-end labeling, intravitreal injections, mice, neuroprotective effect

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 9. doi:https://doi.org/10.1167/iovs.64.12.9

Regulation of Axon Guidance by Slit2 and Netrin-1 Signaling in the Lacrimal Gland of Aqp5 Knockout Mice Open Access

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Ying Bai; Guohu Di; Huanhuan Ge; Bin Li; Kaier Zhang; Di Zhang; Dianqiang Wang; Peng Chen

Tags: langer-giedion syndrome, mice, netrin-1, neurons, axon

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 27. doi:https://doi.org/10.1167/iovs.64.12.27

A Simplified Model of Activation and Deactivation of Human Rod Phototransduction—An Electroretinographic Study Open Access

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James D. Akula; Annie M. Lancos; Bilal K. AlWattar; Hanna De Bruyn; Ronald M. Hansen; Anne B. Fulton

Tags: phototransduction, rod photoreceptors, electroretinography

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 36. doi:https://doi.org/10.1167/iovs.64.12.36

Visual Psychophysics and Physiological Optics

Brief Adaptation to Astigmatism Reduces Meridional Anisotropy in Contrast Sensitivity Open Access

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Tsz-Wing Leung; Roger W. Li; Chea-Su Kee

Tags: anisotropy, astigmatism, contrast sensitivity, spatial frequency

Investigative Ophthalmology & Visual Science September 2023, Vol.64, 4. doi:https://doi.org/10.1167/iovs.64.12.4

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