Volume 65 Issue 3 | IOVS

Anatomy and Pathology/Oncology

Forward Light Scattering of the Vitreous Gel After Enzymatic Aging: An In Vitro Model to Study Vitreous Opacification Open Access

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Maximilian Hammer; Marcel Muuss; Sonja Schickhardt; Alexander Scheuerle; Ramin Khoramnia; Grzegorz Łabuz; Philipp Uhl; Gerd Uwe Auffarth

Tags: opacification, vitreous body, aging, bromelains, hyaluronic acid

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 36. doi:https://doi.org/10.1167/iovs.65.3.36

IL-6-Driven Autocrine Lactate Promotes Immune Escape of Uveal Melanoma Open Access

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Chaoju Gong; Meiling Yang; Huirong Long; Xia Liu; Qing Xu; Lei Qiao; Haibei Dong; Yalu Liu; Suyan Li

Tags: hla-e antigens, interleukin-6, lactates, programmed cell death 1 ligand 1, proteins

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 37. doi:https://doi.org/10.1167/iovs.65.3.37

scRNA-Seq: First Atlas and Cellular Landscape of Lacrimal Sac: Implications in Primary Acquired Nasolacrimal Duct Obstruction Pathogenesis Open Access

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Wenyue Zhang; Huan Huang; Xueru Liu; Leilei Zhang; Lunhao Li; Yi Ding; Yichuan Xiao; Mohammad Javed Ali; Hao Sun; Caiwen Xiao

Tags: epithelial cells, genes, lacrimal sac, nasolacrimal duct obstruction, pathogenesis

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 38. doi:https://doi.org/10.1167/iovs.65.3.38

Biochemistry and Molecular Biology

Unraveling the Intraday Variations in the Tear Fluid Proteome Open Access

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Garrett Jones; Jeremy Altman; Saleh Ahmed; Tae Jin Lee; Wenbo Zhi; Shruti Sharma; Ashok Sharma

Tags: proteins, proteome

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 2. doi:https://doi.org/10.1167/iovs.65.3.2

Isolation and Characterization of Extracellular Vesicles Through Orthogonal Approaches for the Development of Intraocular EV Therapy Open Access

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Justin Leung; Dimitrios Pollalis; Gopa K. G. Nair; Jeffrey K. Bailey; Britney O. Pennington; Amir I. Khan; Kaitlin R. Kelly; Ashley K. Yeh; Kartik S. Sundaram; Dennis O. Clegg; Chen-Ching Peng; Liya Xu; Sun Young Lee

Tags: extracellular vesicles, mass or substance concentration per volume, particle, patient isolation, proteins

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 6. doi:https://doi.org/10.1167/iovs.65.3.6

Investigating the Impact of Dimer Interface Mutations on Norrin's Secretion and Norrin/β-Catenin Pathway Activation Open Access

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Min Liu; Erkuan Dai; Mu Yang; Shujin Li; Lin Fan; Yining Liu; Haodong Xiao; Peiquan Zhao; Zhenglin Yang

Tags: bodily secretions, dimers, mutation, proteins, gain of function mutation

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 31. doi:https://doi.org/10.1167/iovs.65.3.31

NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β Open Access

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Christopher M. McCurry; Siddharth Sunilkumar; Sandeep M. Subrahmanian; Esma I. Yerlikaya; Allyson L. Toro; Ashley M. VanCleave; Shaunaci A. Stevens; Alistair J. Barber; Jeffery M. Sundstrom; Michael D. Dennis

Tags: diabetes mellitus, mice, nlr family, pyrin domain-containing 3 protein, retina, inflammasomes

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 34. doi:https://doi.org/10.1167/iovs.65.3.34

Clinical and Epidemiologic Research

Evaluation of the Observational Associations and Shared Genetics Between Glaucoma With Depression and Anxiety Open Access

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Xiayin Zhang; Yingying Liang; Yu Huang; Shunming Liu; Qinyi Li; Shan Wang; Guanrong Wu; Zijing Du; Yaxin Wang; Jinghui Wang; Yunyan Hu; Siwen Zang; Yijun Hu; Xianwen Shang; Xueli Zhang; Lei Zhang; Andrew Brown; Zhuoting Zhu; Mingguang He; Honghua Yu

Tags: anxiety, depressive disorders, genetics, glaucoma, mental disorders

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 12. doi:https://doi.org/10.1167/iovs.65.3.12

Longitudinal Changes in Choroidal Thickness Varied With Refractive Progression in Myopic and Non-Myopic Children: A Two-Year Cohort Study Open Access

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Menglu Shen; Xiaotong Han; Yan Yang; Hailu Huang; Jinen Hou; Ling Jin; Xinping Yu; Yangfa Zeng; Mingguang He

Tags: child, cohort studies, myopia

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 17. doi:https://doi.org/10.1167/iovs.65.3.17

The Association Between Metformin Use and New-Onset ICD Coding of Geographic Atrophy Open Access

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John Moir; Max J. Hyman; Reem Gonnah; Andrea Flores; Seenu M. Hariprasad; Dimitra Skondra

Tags: age-related macular degeneration, nonexudative, metformin, diabetes mellitus, diabetes mellitus, type 2

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 23. doi:https://doi.org/10.1167/iovs.65.3.23

Macular Curvature in Adults Born Preterm With and Without ROP: Results from the Gutenberg Prematurity Eye Study Open Access

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Achim Fieß; Christin Volmering; Sandra Gißler; Eva Mildenberger; Michael S. Urschitz; Panagiotis Laspas; Bernhard Stoffelns; Norbert Pfeiffer; Alexander K. Schuster

Tags: adult, eye, infant, premature, premature birth, perinatal period

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 39. doi:https://doi.org/10.1167/iovs.65.3.39

Cornea

Persistence of Contact Lens-Induced Corneal Parainflammation Following Lens Removal Open Access

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Ananya Datta; Ji Hyun Lee; Tiffany Truong; Orneika Flandrin; Yujia Yang; David J. Evans; Suzanne M. J. Fleiszig

Tags: cornea, lens (device), lens, crystalline, persistence, mice

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 8. doi:https://doi.org/10.1167/iovs.65.3.8

NEAT1 Deficiency Promotes Corneal Epithelial Wound Healing by Activating cAMP Signaling Pathway Open Access

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Tian Sang; Yani Wang; Zhiqing Wang; Di Sun; Shengqian Dou; Yaoyao Yu; Xiaoyun Wang; Can Zhao; Qun Wang

Tags: cornea, cyclic amp, epithelium, signal pathway, signal transduction pathways

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 10. doi:https://doi.org/10.1167/iovs.65.3.10

Substrate Stiffness Modulates Stemness and Differentiation of Rabbit Corneal Endothelium Through the Paxillin–YAP Pathway Open Access

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Shuting Liu; Hua Chen; Huatao Xie; Xin Liu; Mingchang Zhang

Tags: chronic exertional compartment syndrome, cornea, corneal endothelium, oryctolagus cuniculus, scirrhous adenocarcinoma

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 15. doi:https://doi.org/10.1167/iovs.65.3.15

Expression of ATP-Binding Cassette Transporter A1 (ABCA1) in Eyelid Tissues and Meibomian Gland Epithelial Cells Open Access

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Fang Zheng; Jingjing Su; Jiaoman Wang; Qing Zhan; Mei Su; Sicheng Ding; Wei Li; Ying-Ting Zhu; Ping Guo

Tags: abca1 gene, body tissue, epithelial cells, eyelid, meibomian gland

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 24. doi:https://doi.org/10.1167/iovs.65.3.24

Diabetic Ocular Surface Has Defects in Oxygen Uptake Revealed by Optic Fiber Microsensor Open Access

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Sun Qin; Li Ma; Fernando Ferreira; Chelsea Brown; Manuel F. Navedo; Brian Reid; Min Zhao

Tags: cornea, diabetes mellitus, ocular surfaces, oxygen, optics

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 27. doi:https://doi.org/10.1167/iovs.65.3.27

Primary Cilium in Neural Crest Cells Crucial for Anterior Segment Development and Corneal Avascularity Open Access

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Seungwoon Seo; Seong Keun Sonn; Hyae Yon Kweon; Jing Jin; Tsutomu Kume; Je Yeong Ko; Jong Hoon Park; Goo Taeg Oh

Tags: cilia, cornea, mice, neural crest cells, corneal stroma

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 30. doi:https://doi.org/10.1167/iovs.65.3.30

Lack of Elevated Expression of TGFβ3 Contributes to the Delay of Epithelial Wound Healing in Diabetic Corneas Open Access

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Nan Gao; Fu-Shin Yu

Tags: cornea, diabetes mellitus, epithelium, protein isoforms, wound healing

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 35. doi:https://doi.org/10.1167/iovs.65.3.35

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Alteration of Neurotrophic Factors and Innervation in Extraocular Muscles of Individuals With Concomitant Esotropia Open Access

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Jie Hao; Meixu Wang; Jiawen Liu; Mayinuer Yusufu; Kai Cao; Jing Fu

Tags: esotropia, insulin-like growth factor i, muscle of orbit, nerve growth factors, nerve supply

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 1. doi:https://doi.org/10.1167/iovs.65.3.1

Multifaceted Interactions of Stereoacuity, Inter-Ocular Suppression, and Fixation Eye Movement Abnormalities in Amblyopia and Strabismus Open Access

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Gokce Busra Cakir; Jordan Murray; Cody Dulaney; Fatema Ghasia

Tags: amblyopia, strabismus

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 19. doi:https://doi.org/10.1167/iovs.65.3.19

Effects of Monocular Flicker on Binocular Imbalance in Amblyopic and Nonamblyopic Adults Open Access

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Yiqiu Lu; Liying Zou; Wenjing Wang; Ruyin Chen; Jia Qu; Jiawei Zhou

Tags: amblyopia, imbalance, photopsia, adult, eye

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 33. doi:https://doi.org/10.1167/iovs.65.3.33

Genetics

High Clinical Exome Sequencing Diagnostic Rates and Novel Phenotypic Expansions for Nonisolated Microphthalmia, Anophthalmia, and Coloboma Open Access

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Bhavana Kunisetty; Bailey A. Martin-Giacalone; Xiaonan Zhao; Pamela N. Luna; Brian P. Brooks; Robert B. Hufnagel; Chad A. Shaw; Jill A. Rosenfeld; A. J. Agopian; Philip J. Lupo; Daryl A. Scott

Tags: cauda equina syndrome, cesium, complement membrane attack complex, genes, mac protocol

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 25. doi:https://doi.org/10.1167/iovs.65.3.25

Novel Splicing Variants in the ARR3 Gene Cause the Female-Limited Early-Onset High Myopia Open Access

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Jianing Niu; Weili Zhu; Xiaoying Jin; Xiaoming Teng; Junyu Zhang

Tags: family, genes, myopia, rna splicing, rna, messenger

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 32. doi:https://doi.org/10.1167/iovs.65.3.32

Glaucoma

Clinical Significance of Recurrent Disc Hemorrhage and Choroidal Microvasculature Dropout on Optical Coherence Tomography Angiography in Glaucoma Open Access

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Si Eun Oh; Hee Jong Shin; Chan Kee Park; Hae-Young Lopilly Park

Tags: angiogram, glaucoma, hemorrhage, microvascular network, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 5. doi:https://doi.org/10.1167/iovs.65.3.5

ANGPTL7 and Its Role in IOP and Glaucoma Open Access

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Suzette Farber-Katz Brown; Hien Nguyen; Philip Mzyk; Michael L. De Ieso; Andrea M. Unser; Ian Brown; Pujhitha Ramesh; Hira Afzaal; Feryan Ahmed; Karen Y. Torrejon; Alan Nhan; Dalton Markrush; Tom Daly; Ellie Knecht; William McConaughy; Sara Halmos; Zhiquan Lucy Liu; Rachel Rennard; Andrew Peterson; W. Daniel Stamer

Tags: antibodies, eye, glaucoma, intraocular pressure, mice

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 22. doi:https://doi.org/10.1167/iovs.65.3.22

Natural History and Risk Factors for Glaucoma Progression in Chinese Patients With Normal-Tension Glaucoma Open Access

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De-Fu Chen; Chenmin Wang; Yuqing Si; Xiaonan Lu; Weihe Zhou; Qiangjie Huang; Jingjing Zuo; Gangwei Cheng; Dexter Y. L. Leung; Ningli Wang; David S. Friedman; Yuanbo Liang

Tags: chinese (other dialects), chinese people, did not receive therapy or drug, glaucoma, low tension glaucoma

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 28. doi:https://doi.org/10.1167/iovs.65.3.28

Immunology and Microbiology

Exploring Heparanase Levels in Tears: Insights From Herpes Simplex Virus-1 Keratitis Patients and Animal Studies Open Access

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Satyashree Gagan; Agimanailiu Khapuinamai; Divya Kapoor; Pankaj Sharma; Tejabhiram Yadavalli; Joveeta Joseph; Deepak Shukla; Bhupesh Bagga

Tags: heparanase, herpes simplex infection, human herpesvirus 1, keratitis, mice

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 7. doi:https://doi.org/10.1167/iovs.65.3.7

Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis Open Access

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Xiaoyan Guo; Zijun Zhang; Qiankun Chen; Leying Wang; Xizhan Xu; Zhenyu Wei; Yang Zhang; Kexin Chen; Zhiqun Wang; Xinxin Lu; Qingfeng Liang

Tags: cornea, genes, keratitis, nocardia, family

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 26. doi:https://doi.org/10.1167/iovs.65.3.26

Multidisciplinary Ophthalmic Imaging

Adaptive Optics Retinal Imaging in RDH12-Associated Early Onset Severe Retinal Dystrophy Open Access

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Malena Daich Varela; Mira Dixit; Angelos Kalitzeos; Michel Michaelides

Tags: diagnostic imaging, optics, retinal cone, retinal dystrophies, retinal imaging

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 9. doi:https://doi.org/10.1167/iovs.65.3.9

Quantitative Evaluation of the Topographical Maps of Three-Dimensional Choroidal Vascularity Index in Children With Different Degrees of Myopia Open Access

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Fang Liu; Yuhao Ye; Weiming Yang; Jing Wang; Ye Xu; Yu Zhao; Meng Li; Zhi Chen; Yang Shen; Meiyan Li; Xingtao Zhou

Tags: cardiovascular imaging, child, cortical blindness, maps, myopia

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 14. doi:https://doi.org/10.1167/iovs.65.3.14

Distinct Pathways of Macular Atrophy in Type 3 Macular Neovascularization Associated With AMD Open Access

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Enrico Borrelli; Costanza Barresi; Federico Ricardi; Alessandro Berni; Domenico Grosso; Pasquale Viggiano; Paola Marolo; Ugo Introini; Michele Reibaldi; Francesco Bandello

Tags: atrophoderma maculatum, macular neovascularization, type 3 macular neovascularization, eye

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 18. doi:https://doi.org/10.1167/iovs.65.3.18

Acetazolamide Challenge Changes Outer Retina Bioenergy-Linked and Anatomical OCT Biomarkers Depending on Mouse Strain Open Access

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Bruce A. Berkowitz; Anuhya Paruchuri; Josh Stanek; Robert H. Podolsky; Karen Lins Childers; Robin Roberts

Tags: acetazolamide, biological markers, mice, mitochondria, retina

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 21. doi:https://doi.org/10.1167/iovs.65.3.21

Retina

Quantitative Foveal Structural Metrics as Predictors of Visual Acuity in Human Albinism Open Access

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Erica N. Woertz; Gelique D. Ayala; Niamh Wynne; Sergey Tarima; Serena Zacharias; Murray H. Brilliant; Taylor M. Dunn; Deborah Costakos; C. Gail Summers; Sasha Strul; Arlene V. Drack; Joseph Carroll

Tags: albinism, foveal hypoplasia, visual acuity

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 3. doi:https://doi.org/10.1167/iovs.65.3.3

Genotype-Phenotype of CRB1-Associated Early-Onset Retinal Dystrophy: Novel Insights on Retinal Architecture and Therapeutic Window for Clinical Trials Open Access

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Yili Jin; Songshan Li; Zhaoxin Jiang; Limei Sun; Li Huang; Ting Zhang; Xinyu Liu; Xiaoyan Ding

Tags: genotype, phenotype, retinal dystrophies, therapeutic index, child

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 11. doi:https://doi.org/10.1167/iovs.65.3.11

Personalized Lens Correction Improves Quantitative Fundus Autofluorescence Analysis Open Access

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Leon von der Emde; Geena C. Rennen; Marc Vaisband; Jan Hasenauer; Raffael Liegl; Monika Fleckenstein; Maximilian Pfau; Frank G. Holz; Thomas Ach

Tags: fundus autofluorescence imaging, lens (device), lens, crystalline, diagnostic imaging, cataract

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 13. doi:https://doi.org/10.1167/iovs.65.3.13

Tandem Mass Tag LC-MS/MS of Aqueous Humor From Individuals With Type 2 Diabetes Without Retinopathy Reveals Early Dysregulation of Synaptic Proteins Open Access

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Mira M. Sachdeva; Yoonjung Lee; Eda K. Unlu; Neslihan D. Koseoglu; Eumee Cha; Jiangxia Wang; Christina R. Prescott; Allen O. Eghrari; Chan Hyun Na

Tags: diabetes mellitus, type 2, liquid chromatography-mass spectrometry, proteins, proteomics, retinal diseases

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 16. doi:https://doi.org/10.1167/iovs.65.3.16

The Impact of Photopigment Bleaching on the Human Rod Photoreceptor Subretinal Space Measured Via Optical Coherence Tomography Open Access

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Alina Messner; Valentin Aranha dos Santos; Stefan Puchner; Hannes Stegmann; Andreas Schlatter; Doreen Schmidl; Rainer Leitgeb; Leopold Schmetterer; René M. Werkmeister

Tags: optical coherence tomography, rod photoreceptors, retina, dark adaptation, light adaptation

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 20. doi:https://doi.org/10.1167/iovs.65.3.20

Prevalence of Myopic Maculopathy Among the Very Old: The Ural Very Old Study Open Access

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Mukharram M. Bikbov; Timur R. Gilmanshin; Gyulli M. Kazakbaeva; Songhomitra Panda-Jonas; Jost B. Jonas

Tags: eye, macular disorders, myopic macular degeneration, prevalence, myopia

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 29. doi:https://doi.org/10.1167/iovs.65.3.29

Review

Age-Related Macular Degeneration, a Mathematically Tractable Disease Open Access

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Christine A. Curcio; Deepayan Kar; Cynthia Owsley; Kenneth R. Sloan; Thomas Ach

Tags: age-related macular degeneration, aging, drusen, eye, fovea centralis

Investigative Ophthalmology & Visual Science March 2024, Vol.65, 4. doi:https://doi.org/10.1167/iovs.65.3.4

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