Volume 65 Issue 11 | IOVS

Anatomy and Pathology/Oncology

Administration of Nicotine Can Inhibit Myopic Growth in Animal Models Open Access

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Kate Thomson; Cindy Karouta; Regan Ashby

Tags: nicotine

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 29. doi:https://doi.org/10.1167/iovs.65.11.29

Biochemistry and Molecular Biology

Metabolic Phenotyping of Healthy and Diseased Human RPE Cells Open Access

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Saira Rizwan; Beverly Toothman; Bo Li; Abbi L. Engel; Rayne R. Lim; Sheldon Niernberger; Jinyu Lu; Cloe Ratliff; Yinxiao Xiang; Mark Eminhizer; Jennifer R. Chao; Jianhai Du

Tags: glutamine, nutrients, phenotype determination, retinal pigment cell, sugars

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 5. doi:https://doi.org/10.1167/iovs.65.11.5

The Effects of STRA6 Regulation of the Circadian Rhythm on Choroidal Neovascularization Open Access

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Ying Yang; Shenglai Zhang; Shu Su; Xiaowei Yang; Jia Chen; Aimin Sang

Tags: choroidal neovascularization, circadian rhythms, mice, circadian rhythm disorders, proteins

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 21. doi:https://doi.org/10.1167/iovs.65.11.21

Clinical and Epidemiologic Research

Prognostic Impact of Notch1 Intracellular Domain, P63, and c-MYC in Lacrimal Gland Adenoid Cystic Carcinoma Open Access

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Jiawei Zhao; Michelle D. Williams; Mike Hernandez; Grace Kuang; Hila Goldberg; Janet Fan; Jing Ning; Renata Ferrarotto; Bita Esmaeli

Tags: adenoid cystic carcinoma, c-myc genes, lacrimal gland, notch1 gene, patient prognosis

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 4. doi:https://doi.org/10.1167/iovs.65.11.4

Visual Performance of People With Albinism Assessed With Generalizable and Adaptive AIM and FInD Methods Open Access

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Jan Skerswetat; Nicole Christie Ross; Cecilia Idman-Rait; Katie Sun; Olivia Wynn; Peter John Bex

Tags: albinism, color, contrast sensitivity, motion, noise

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 34. doi:https://doi.org/10.1167/iovs.65.11.34

Cornea

RNA-Seq Analysis Unraveling Novel Genes and Pathways Influencing Corneal Wound Healing Open Access

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Rajnish Kumar; Ratnakar Tripathi; Nishant R. Sinha; Rajiv R. Mohan

Tags: cornea, genes, rna-seq, wound healing, proteins

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 13. doi:https://doi.org/10.1167/iovs.65.11.13

RTP4 Enhances Corneal HSV-1 Infection in Mice With Type 2 Diabetes Mellitus Open Access

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Yunhai Dai; Shilan Mao; Xinyi Zang; Hongqi Ge; Jing Feng; Yalin Wang; Xia Qi; Lingling Yang; Qingjun Zhou; Xiaolei Wang

Tags: cornea, diabetes mellitus, type 2, human herpesvirus 1, infections, mice

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 36. doi:https://doi.org/10.1167/iovs.65.11.36

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys Open Access

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Ming Zhou; Zhuo-Xing Shi; Zhong Liu; Shu-Rui Ke; Chao-Yang Wang; Xiao-Lin Liang; Qiu-Ling Hu; Qi-Kai Zhang; Dong-Liang Wang; Li Sun; Yu-Heng Lin; Qi Dai; Ying-Feng Zheng

Tags: cornea, corneal epithelium, genes, macaca fascicularis, wound healing

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 43. doi:https://doi.org/10.1167/iovs.65.11.43

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Effects of Short-Term Treatment of Rabbit Extraocular Muscle With Ciliary Neurotrophic Factor Open Access

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Jolene C. Rudell; Linda K. McLoon

Tags: ciliary neurotrophic factor, muscle, muscle of orbit, oryctolagus cuniculus, superior rectus muscle

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 41. doi:https://doi.org/10.1167/iovs.65.11.41

Eccentricity Dependency of Retinal Electrophysiological Deficits in People With Episodic Migraine Open Access

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Bao N. Nguyen; Adela S. Y. Park; Allison M. McKendrick

Tags: electroretinography, episodic migraine, migraine disorders, visual fields, headache

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 44. doi:https://doi.org/10.1167/iovs.65.11.44

Glaucoma

Long-Term Changes in Lamina Cribrosa Curvature Index After Trabeculectomy in Glaucomatous Eyes Open Access

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Xiao Shang; Nathanael Urs Häner; Joel-Benjamin Lincke; Valentin Pfeiffer; Pascal Aurel Gubser; Martin Sebastian Zinkernagel; Jan Darius Unterlauft

Tags: cribriform plate, eye, glaucoma, intraocular pressure, trabeculectomy

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 3. doi:https://doi.org/10.1167/iovs.65.11.3

Iris Morphological and Biomechanical Factors Influencing Angle Closure During Pupil Dilation Open Access

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Royston K. Y. Tan; Gim Yew Ng; Tin A. Tun; Fabian A. Braeu; Monisha E. Nongpiur; Tin Aung; Michaël J. A. Girard

Tags: iris, mydriasis, pupil dilation, anterior chamber of eye

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 7. doi:https://doi.org/10.1167/iovs.65.11.7

Using Multi-Layer Perceptron Driven Diagnosis to Compare Biomarkers for Primary Open Angle Glaucoma Open Access

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Nicholas Riina; Alon Harris; Brent A. Siesky; Lukas Ritzer; Louis R. Pasquale; James C. Tsai; James Keller; Barbara Wirostko; Julia Arciero; Brendan Fry; George Eckert; Alice Verticchio Vercellin; Gal Antman; Paul A. Sidoti; Giovanna Guidoboni

Tags: biological markers, neural networks (computer), open-angle glaucoma, glaucoma, datasets

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 16. doi:https://doi.org/10.1167/iovs.65.11.16

Immunology and Microbiology

In Vivo Visualization of Intravascular Patrolling Immune Cells in the Primate Eye Open Access

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Drew Ashbery; Hector C. Baez; Rye E. Kanarr; Karteek Kunala; Derek Power; Colin J. Chu; Jesse Schallek; Juliette E. McGregor

Tags: diagnostic imaging, eye, primates, phase contrast

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 23. doi:https://doi.org/10.1167/iovs.65.11.23

Poor Response to Bevacizumab Correlates With Higher IL-6 and IL-8 Aqueous Cytokines in AMD Open Access

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Emma Connolly; Ghaleb El-Farouki; Kiva Brennan; Mark Cahill; Sarah L. Doyle

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 37. doi:https://doi.org/10.1167/iovs.65.11.37

Relationship Between Fluoroquinolone Resistance and Mutations in the Quinolone Resistance-Determining Region in Corynebacterium macginleyi Open Access

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Nobuhiro Kato; Masatoshi Haruta; Rikki Arai; Kazunori Sato; Kei Furushima; Kanako Yokomizo; Miki Okuno; Takeshi Yamamoto; Yoshitoshi Ogura; Shigeo Yoshida

Tags: corynebacterium, fluoroquinolones, mutation, quinolones, resistance genes

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 38. doi:https://doi.org/10.1167/iovs.65.11.38

Lens

Lens Power and Associated Factors in Nonhuman Primate Subjects: A Cross-sectional Study Open Access

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Yingting Zhu; Rui Xie; Qi Zhang; Yuan Zhang; Guitong Ye; Liangzhi Xu; Simeng Hou; Wei Liu; Zhiwei Huang; Jian Wu; Yehong Zhuo

Tags: cross-sectional studies, eye, lens, crystalline, primates, myopia

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 2. doi:https://doi.org/10.1167/iovs.65.11.2

Prospective Cytokine Profiling in Aqueous Humor Reveals a Proinflammatory Microenvironment in Highly Dense Nuclear Cataracts Open Access

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Catharina Latz; Annika Licht; Alireza Mirshahi; Eicke Latz; Kai Zimmer

Tags: aqueous humor, cataract, nuclear, cytokine, hypertension, cataract

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 25. doi:https://doi.org/10.1167/iovs.65.11.25

Altered Cell Clusters and Upregulated Aqp1 in Connexin 50 Knockout Lens Epithelium Open Access

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Chun-Hong Xia; William Lin; Rachel Li; Xinfang Xing; Guangdu Jack Shang; Haiwei Zhang; Xiaohua Gong

Tags: aquaporin 1, gap junction protein, lens (device), lens epithelial cell, lens epithelium

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 27. doi:https://doi.org/10.1167/iovs.65.11.27

Zebrafish Optical Development Requires Regulated Water Permeability by Aquaporin 0 Open Access

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Olga Safrina; Irene Vorontsova; Paul J. Donaldson; Thomas F. Schilling

Tags: cell nucleus, lens (device), lens, crystalline, optics, permeability

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 42. doi:https://doi.org/10.1167/iovs.65.11.42

Multidisciplinary Ophthalmic Imaging

Quantitative Perfusion-Weighted Magnetic Resonance Imaging in Uveal Melanoma Open Access

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Lisa Klaassen; Myriam G. Jaarsma-Coes; Marina Marinkovic; Gregorius P. M. Luyten; Coen R. N. Rasch; Teresa A. Ferreira; Jan-Willem M. Beenakker

Tags: magnetic resonance imaging, neoplasms, perfusion, uveal melanoma, pigmentation

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 17. doi:https://doi.org/10.1167/iovs.65.11.17

Characterizing Presumed Displaced Retinal Ganglion Cells in the Living Human Retina of Healthy and Glaucomatous Eyes Open Access

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Mary E. Marte; Kazuhiro Kurokawa; HaeWon Jung; Yan Liu; Marcel T. Bernucci; Brett J. King; Donald T. Miller

Tags: diagnostic imaging, glaucoma, retina, eye, retinal ganglion cells

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 20. doi:https://doi.org/10.1167/iovs.65.11.20

Plexus-Specific Retinal Capillary Blood Flow Analysis Using Erythrocyte Mediated Angiography and Optical Coherence Tomography Angiography Open Access

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Victoria Y. Chen; Jessica A. Pottenburgh; Shih-En Chen; Sarah Kim; Lakyn Mayo; Aashka Damani; Marvin Cruz; Ashley Park; Lily Im; Laurence Magder; Osamah J. Saeedi

Tags: angiogram, blood capillaries, erythrocytes, vascular flow, velocity

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 33. doi:https://doi.org/10.1167/iovs.65.11.33

Retina

Changes in Intrinsically Photosensitive Retinal Ganglion Cells, Dopaminergic Amacrine Cells, and Their Connectivity in the Retinas of Lid Suture Myopia Open Access

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Ying Ling; Yao Wang; Jingjing Ye; Changlin Luan; Ailing Bi; Yu Gu; Xuefeng Shi

Tags: dopamine, eye, myopia, retina, sutures

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 8. doi:https://doi.org/10.1167/iovs.65.11.8

Enhancing the Retinopathy Of Prematurity Risk Profile Through Placental Evaluation of Maternal and Fetal Vascular Malperfusion Open Access

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Salma El Emrani; Esther J. S. Jansen; Jelle J. Goeman; Jacqueline U. M. Termote; Enrico Lopriore; Nicoline E. Schalij-Delfos; Lotte E. van der Meeren

Tags: fetus, hypoperfusion, mothers, placenta, retinopathy of prematurity

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 9. doi:https://doi.org/10.1167/iovs.65.11.9

Intraocular Concentration of Stem Cell Factor/c-KIT and Galectin-1 in Retinal Diseases Open Access

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Yong Je Choi; Hyeong Min Kim; Tae-Young Na; Kyu Hyung Park; Sang Gyu Park; Se Joon Woo

Tags: cytokine, mass or substance concentration per volume, proto-oncogene protein c-kit, retinal diseases, vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 11. doi:https://doi.org/10.1167/iovs.65.11.11

Association of Retinal Nerve Fiber Layer Thinning With Elevated High Density Lipoprotein Cholesterol in UK Biobank Open Access

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Yiyuan Ma; Yue Wu; Ling Jin; Leyi Hu; Wen Chen; Charlotte Aimee Young; Xinyu Zhang; Danying Zheng; Zhenzhen Liu; Guangming Jin

Tags: high density lipoprotein cholesterol, retinal nerve fiber layer, uk biobank

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 12. doi:https://doi.org/10.1167/iovs.65.11.12

Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Parameters and Their Associated Factors in Cynomolgus Macaques Open Access

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Yuan Zhang; Guitong Ye; Kezhe Chen; Shaofen Huang; Rui Xie; Jianqi Chen; Wei Liu; Zhiwei Wang; Ruiyu Luo; Jinan Zhan; Yehong Zhuo; Yiqing Li; Yingting Zhu

Tags: ganglia, macaca fascicularis, retinal nerve fiber layer, cercopithecidae, nose

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 14. doi:https://doi.org/10.1167/iovs.65.11.14

Aqueous Humor Cytokine Analysis in Age-Related Macular Degeneration After Switching From Aflibercept to Faricimab Open Access

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Takahito Todoroki; Jun Takeuchi; Hikaru Ota; Yuyako Nakano; Ai Fujita Sajiki; Koichi Nakamura; Hiroki Kaneko; Koji M. Nishiguchi

Tags: aflibercept, age-related macular degeneration, aqueous humor, cytokine, faricimab

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 15. doi:https://doi.org/10.1167/iovs.65.11.15

Loss of ON-Pathway Function in Mice Lacking Lrit3 Decreases Recovery From Lens-Induced Myopia Open Access

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Baptiste Wilmet; Christelle Michiels; Jingyi Zhang; Jacques Callebert; José Alain Sahel; Serge Picaud; Isabelle Audo; Christina Zeitz

Tags: lens (device), lens, crystalline, mice, myopia, recovery of function

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 18. doi:https://doi.org/10.1167/iovs.65.11.18

A Mathematical Model of Interstitial Fluid Flow and Retinal Tissue Deformation in Macular Edema Open Access

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Alessia Ruffini; Mariia Dvoriashyna; Andrea Govetto; Mario R. Romano; Rodolfo Repetto

Tags: body tissue, fluid flow, macular edema, retina, minimally conscious state

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 19. doi:https://doi.org/10.1167/iovs.65.11.19

Multilayer Retinal Correspondence of the Structural and Vascular Anomalies in Eyes With Early Macular Telangiectasia Type 2 Open Access

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Valérie Krivosic; Zoe Dobbels; Cedric Duliere; Abir Zureik; Ramin Tadayoni; Alain Gaudric

Tags: eye, retinal cone, retinal correspondence, telangiectasis, vascular anomalies

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 24. doi:https://doi.org/10.1167/iovs.65.11.24

Quantitative Evaluation of Type 1 and Type 2 Choroidal Neovascularization Components Under Treatment With Projection-Resolved OCT Angiography Open Access

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Kotaro Tsuboi; Qi Sheng You; Jie Wang; Yukun Guo; Christina J. Flaxel; Thomas S. Hwang; David Huang; Yali Jia; Steven T. Bailey

Tags: angiogram, choroidal neovascularization, macular neovascularization, undertreatment, eye

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 32. doi:https://doi.org/10.1167/iovs.65.11.32

Retinal Cell Biology

Knockdown of HSPA13 Inhibits TGFβ1-Induced Epithelial-Mesenchymal Transition of RPE by Suppressing the PI3K/Akt Signaling Pathway Open Access

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Furong Gao; Mengwen Li; Lilin Zhu; Jiao Li; Jie Xu; Song Jia; Qingjian Ou; Caixia Jin; Haibin Tian; Juan Wang; Jingying Xu; Wei Xu; Guo-Tong Xu; Lixia Lu

Tags: 1-phosphatidylinositol 3-kinase, akt signaling pathway, epithelial to mesenchymal transition, phosphoinositide 3-kinase, retinal pigment cell

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 1. doi:https://doi.org/10.1167/iovs.65.11.1

iPSC-Derived LCHADD Retinal Pigment Epithelial Cells Are Susceptible to Lipid Peroxidation and Rescued by Transfection of a Wildtype AAV-HADHA Vector Open Access

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Tiffany DeVine; Gabriela Elizondo; Garen Gaston; Shannon J. Babcock; Dietrich Matern; Mikhail S. Shchepinov; Mark E. Pennesi; Cary O. Harding; Melanie B. Gillingham

Tags: disease vectors, induced pluripotent stem cells, ketones, lipid peroxidation, retinal pigment cell

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 22. doi:https://doi.org/10.1167/iovs.65.11.22

Blue Light-Induced Accelerated Formation of Melanolipofuscin-Like Organelles in Japanese Quail RPE Cells: An Electron Microscopic Study Open Access

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Natalia B. Serejnikova; Natalia N. Trofimova; Marina A. Yakovleva; Alexander E. Dontsov; Pavel P. Zak; Mikhail A. Ostrovsky

Tags: granules, japanese, lipofuscin, organelles, quail

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 31. doi:https://doi.org/10.1167/iovs.65.11.31

ER Stress and Mitochondrial Perturbations Regulate Cell Death in Retinal Detachment: Exploring the Role of HIF1α Open Access

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Bhavneet Kaur; Bruna Miglioranza Scavuzzi; Mengling Yang; Jingyu Yao; Lin Jia; Steven F. Abcouwer; David N. Zacks

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 39. doi:https://doi.org/10.1167/iovs.65.11.39

Visual Neuroscience

Acute Effects of Oral Caffeine Intake on Human Global-Flash mfERG Responses: A Placebo-Controlled, Double-Masked, Balanced Crossover Study Open Access

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Jesús Vera; Beatriz Redondo; Fuensanta A. Vera-Diaz; Athanasios Panorgias

Tags: caffeine, placebos

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 10. doi:https://doi.org/10.1167/iovs.65.11.10

Delayed Surgical Reversal of Optic Nerve Compression Leads to Exponential Degeneration of Optic Nerve Fibers and Selective Sparing of the Small Fibers Open Access

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XiaoHui Jiang; Boyue Xu; Shuang Yao; Zhuowei Wang; Mingyue Liu; Yikui Zhang; Wencan Wu; Ende Wu

Tags: axon, decompression, external, decompressive incision, optic nerve, optic nerve compression

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 40. doi:https://doi.org/10.1167/iovs.65.11.40

Visual Psychophysics and Physiological Optics

Ocular Accommodative and Pupillary Responses During Fixation on Augmented Reality With a Maxwellian Display Open Access

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Masakazu Hirota; Kakeru Sasaki; Kanako Kato; Ryota Nakagomi; Ryusei Takigawa; Chinatsu Kageyama; Seiji Morino; Makoto Suzuki; Toshifumi Mihashi; Atsushi Mizota; Takao Hayashi

Tags: augmented reality, pupil, pupil reaction, visual accommodation, eye

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 30. doi:https://doi.org/10.1167/iovs.65.11.30

Review

Mathematical Models of Ocular Drug Delivery Open Access

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Amir Sadeghi; Astrid Subrizi; Eva M. del Amo; Arto Urtti

Tags: aqueous humor, body tissue, drug delivery systems, eye, mathematical model

Investigative Ophthalmology & Visual Science September 2024, Vol.65, 28. doi:https://doi.org/10.1167/iovs.65.11.28

Erratum

Erratum in: Molecular Responses of Anti-VEGF Therapy in Neovascular Age-Related Macular Degeneration: Integrative Insights From Multi-Omics and Clinical Imaging Open Access

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Investigative Ophthalmology & Visual Science September 2024, Vol.65, 6. doi:https://doi.org/10.1167/iovs.65.11.6

Erratum in: Frequency and Genetic Spectrum of Inherited Retinal Dystrophies in a Large Dutch Pediatric Cohort: The RD5000 Consortium Open Access

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Investigative Ophthalmology & Visual Science September 2024, Vol.65, 26. doi:https://doi.org/10.1167/iovs.65.11.26

Erratum in: Metabolic Phenotyping of Healthy and Diseased Human RPE Cells Open Access

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Investigative Ophthalmology & Visual Science September 2024, Vol.65, 35. doi:https://doi.org/10.1167/iovs.65.11.35

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