Current Issue | IOVS | ARVO Journals

Anatomy and Pathology/Oncology

Novel OCT Angiography Features, von Hippel–Lindau Disease Association, and Genetic Characterization of Juxtapapillary Retinal Capillary Hemangiomas Open Access

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Xiaonan Zhuang; Fengjuan Gao; Yi Xuan; Zhongcui Sun; Xiaofeng Ye; Xin Huang; Rui Jiang; Jihong Wu; Min Wang; Qing Chang; Gezhi Xu; Wei Liu

Tags: angiogram, atypical, eye, genetics, retinal capillary hemangioma

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 34. doi:https://doi.org/10.1167/iovs.66.4.34

Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice Open Access

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Senmao Li; Jingbin Xie; Jiayan Xiang; Ruyu Yan; Jiangman Liu; Qiwei Fan; Liyuan Lu; Jiaxin Wu; Jun Liu; Yunxia Xue; Ting Fu; Zhijie Li

Tags: cornea, lacrimal gland, nerve injuries, neurons, rhythm

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 40. doi:https://doi.org/10.1167/iovs.66.4.40

Biochemistry and Molecular Biology

Comparative Evaluation of Cigarette Smoke and a Heated Tobacco Product on Corneal Oxidative Stress in an Air/Liquid Interface Model Open Access

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Sebastiano Giallongo; Francesco Bellia; Andrea Russo; Matteo Fallico; Riccardo Polosa; Niccolò Castellino; Antonio Longo; Rosalia Emma; Konstantinos Partsinevelos; Massimo Caruso; Arief S. Kartasasmita; Giuseppe Sferrazzo; Ignazio Alberto Barbagallo; Rosario Caltabiano; Giuseppe Broggi; Amer M. Alanazi; Giovanni Li Volti

Tags: cigarette smoke, cornea, liquids, oxidative stress, tobacco

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 4. doi:https://doi.org/10.1167/iovs.66.4.4

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling Open Access

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Shuting Lu; Qian Liu; Fan Ye; Ziran Zhang; Lianjun Shi; Xiumiao Li; Wan Mu; Qin Jiang; Biao Yan

Tags: cholesterol metabolism, lymphangiogenesis, lymphatic vessels, rna, cornea

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 26. doi:https://doi.org/10.1167/iovs.66.4.26

NMN Supplementation Inhibits Endothelial Cell ROS-Mediated Src/Pi3k/Akt Signaling Pathway to Protect High-Altitude Blood-Retinal Barrier Open Access

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Siyuan Liu; Ning Du; Keke Ge; Jiayue Hu; Wenfang Zhang

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 51. doi:https://doi.org/10.1167/iovs.66.4.51

Clinical and Epidemiologic Research

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk Open Access

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Wei-Qi Song; Wen-Fang Zhong; Zhi-Hao Li; Dan Liu; Jiao-Jiao Ren; Dong Shen; Jian Gao; Pei-Liang Chen; Jin Yang; Xiao-Meng Wang; Fang-Fei You; Chuan Li; Huan Chen; Jia-Hao Xie; Chen Mao

Tags: glaucoma, genetic predisposition to disease

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 47. doi:https://doi.org/10.1167/iovs.66.4.47

Cornea

Deep Corneal Nerve Plexus Selective Damage in Persistent Neurotrophic Corneal Epithelial Defects Detected by In Vivo Multiphoton Confocal Microscopy Open Access

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Seitaro Komai; Manuel E. Quiroga-Garza; Raul E. Ruiz-Lozano; Nadim S. Azar; Hazem M. Mousa; Sofia Murillo; Symon Ma; Ali Khodor; Sejiro Littleton; Daniel R. Saban; Alain Chédotal; Victor L. Perez

Tags: calcitonin gene-related peptide, cornea, diagnostic imaging, epithelium, neurons

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 1. doi:https://doi.org/10.1167/iovs.66.4.1

Histopathological Evaluation of Corneal Tissues in Microsporidia Stromal Keratitis Open Access

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Sohini Mandal; Soumya Sucharita; Vishwajeet Deshmukh; Smruti Rekha Priyadarshini; Srikant Kumar Sahu; Sujata Das

Tags: body tissue, cornea, histopathology tests, microsporidia, stromal keratitis

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 9. doi:https://doi.org/10.1167/iovs.66.4.9

CD4⁺CD25⁻ T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice Open Access

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Yujing Lin; Lingling Yang; Ya Li; Shengqian Dou; Zhenzhen Zhang; Qingjun Zhou

Tags: antigens, cd25, cornea, diabetes mellitus, mice, nerve degeneration

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 15. doi:https://doi.org/10.1167/iovs.66.4.15

Heterozygous Tcf4 Deficiency Mitigates Fuchs Endothelial Corneal Dystrophy Progression in a Mouse Model Open Access

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Suguru Ito; Yuki Oyama; Taichi Yuasa; Koki Amano; Kotaro Onishi; Ayaka Izumi; Albert S. Jun; Masahito Ikawa; Noriko Koizumi; Naoki Okumura

Tags: cornea, endothelium, hereditary corneal dystrophy, heterozygote, mice

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 19. doi:https://doi.org/10.1167/iovs.66.4.19

Iron-Sulfur Clusters and Iron Responsive Element Binding Proteins Mediate Iron Accumulation in Corneal Endothelial Cells in Fuchs Dystrophy Open Access

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Emma M. Hartness; Hanna Shevalye; Jessica M. Skeie; Timothy Eggleston; Matthew G. Field; Gregory A. Schmidt; Pornpoj Phruttiwanichakun; Aliasger K. Salem; Mark A. Greiner

Tags: carrier proteins, chronic exertional compartment syndrome, cornea, endothelial cells, genes

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 23. doi:https://doi.org/10.1167/iovs.66.4.23

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway Open Access

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Yuzhou Wang; Zhiqiang Xu; Linzhi Wei; Yang Lu; Yizhou Shi; Shiyu Wen; Xiujuan Lv; Kaiyan Huang; Fan Lu; Jia Qu; Liang Hu

Tags: hmgb1 protein, mice, toll-like receptor 4, inflammation, dry eye syndromes

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 28. doi:https://doi.org/10.1167/iovs.66.4.28

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy Open Access

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Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang

Tags: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 36. doi:https://doi.org/10.1167/iovs.66.4.36

Antigen Presentation by Extracellular Vesicles in the Acute Phase of Corneal Transplantation Open Access

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Toshiki Shimizu; Takahiko Hayashi; Junki Kurita; Kentaro Yuda; Nobuhisa Mizuki; Satoru Yamagami

Tags: antigen processing and presentation, extracellular vesicles, keratoplasty, tissue transplants, cornea

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 38. doi:https://doi.org/10.1167/iovs.66.4.38

Quantitative Changes in the Proteome of Chronically Inflamed Lacrimal Glands From a Sjögren's Disease Animal Model Open Access

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Danny Toribio; Junji Morokuma; Dante Pellino; Markus Hardt; Driss Zoukhri

Tags: animal model, langer-giedion syndrome, peptides, proteins, proteome

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 44. doi:https://doi.org/10.1167/iovs.66.4.44

Quantitative Stain-Free Conjunctival Collagen Imaging in Cicatrizing Conjunctivitis Using Second Harmonic Generation-Two Photon Excitation Technology Open Access

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Ralene Sim; Andri K. Riau; Nuur Shahinda Humaira binte Halim; Jodhbir S. Mehta; Hon Shing Ong

Tags: collagen, conjunctiva, conjunctivitis, diagnostic imaging, excitation

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 49. doi:https://doi.org/10.1167/iovs.66.4.49

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege Open Access

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 52. doi:https://doi.org/10.1167/iovs.66.4.52

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Temporal Frequency Modulation of Binocular Balance in Normal and Amblyopic Vision Open Access

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Chenyan Zhou; Jiawei Zhou; Seung Hyun Min

Tags: amblyopia, balance, device, equilibrium, eye, attention

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 8. doi:https://doi.org/10.1167/iovs.66.4.8

The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice Open Access

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Xuechun Wang; Kuan Li; Lingzhi Guo; Xinlong Liu; Yatu Guo; Wei Zhang

Tags: mice, microglia, visual cortex, interneurons, neurons

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 45. doi:https://doi.org/10.1167/iovs.66.4.45

Genetics

Clinical and Molecular Landscape of GLRA2 in X-Linked Early-Onset High Myopia Open Access

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Xiaoxia Li; Siyu Wang; Yuhan Wang; Ruru Chen; Xinjie Mao; Ying Mei; Meiping Xu; Lan Hu; Chuan Qin; Shilai Xing; Xiaoguang Yu; Liya Qiao

Tags: genes, myopia, x-linked inheritance, rna splicing, genetics

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 30. doi:https://doi.org/10.1167/iovs.66.4.30

Clinical Spectrum and Molecular Characteristics of Inherited Ocular Diseases in a Cohort of Pediatric Patients With Infantile Nystagmus Syndrome Open Access

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Xiaoming Gong; Ian P. Boydstun; William T. Lawhon; Nancy N. Hanna; Palak B. Wall; Aaron Flickinger; E. Eugenie Hartmann; Richard W. Hertle

Tags: cohort studies, eye diseases, genes, genetics, pathologic nystagmus

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 39. doi:https://doi.org/10.1167/iovs.66.4.39

Glaucoma

Effects of Verteporfin on Interstitial Fluid Flow-Induced Fibrotic Transdifferentiation of Human Tenon Fibroblasts Open Access

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Janne Frömmichen; Emma Bungert; Jeanne Ströble; Moritz Gläser; Charlotte Gottwald; Kosovare Zeqiri; Thomas Reinhard; Jan Lübke; Günther Schlunck; Cornelius Jakob Wiedenmann

Tags: fibroblasts, fibrosis, fluid flow, interstitial fluid, verteporfin

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 17. doi:https://doi.org/10.1167/iovs.66.4.17

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia Open Access

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Jinpeng Yang; Yangjiani Li; Qi Zhang; Simei Zeng; Haishun Huang; Caiqing Wu; Zhe Liu; Jiahui Tang; Siting Wu; Yuze Chen; Yehong Zhuo; Yangfan Yang; Yiqing Li

Tags: glaucoma, language morphology, morphology, myopia, optic disk

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 18. doi:https://doi.org/10.1167/iovs.66.4.18

Vitamin K1 Alleviates Retinal Inflammation Following Acute Ocular Hypertension by Modulating Microglial Ferroptosis Open Access

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Xi Chen; Yan Rong; Yuxian Jiang; Qiuxiang Zhang; Sifei Xiang; Zhiqi Chen; Wei Chen; Hong Zhang; Chaohua Deng; Junming Wang

Tags: retinitis, vitamin k 1, wounds and injuries, ocular hypertension, ferroptosis

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 46. doi:https://doi.org/10.1167/iovs.66.4.46

Targeted Neuroprotection of Retinal Ganglion Cells Via AAV2-hSyn-NGF Gene Therapy in Glaucoma Models Open Access

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Xinlei Zhu; Benxiang Qi; Zhongmei Ren; Lin Cong; Xiaojing Pan; Qingjun Zhou; Bi Ning Zhang; Lixin Xie

Tags: glaucoma, injections, gene therapy, neuroprotection, retinal ganglion cells

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 48. doi:https://doi.org/10.1167/iovs.66.4.48

Immunology and Microbiology

Role of SerpinA3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts Open Access

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Min Seok Kim; Soo Hyun Choi; Hyun Young Park; Sun Young Jang; JaeSang Ko; Jae-woo Kim; Jin Sook Yoon

Tags: body tissue, fibroblasts, pathogenesis, hyaluronan

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 20. doi:https://doi.org/10.1167/iovs.66.4.20

Single-Cell RNA Sequencing Revealed Functional Conjunctival Keratinocytes Loss via TGF-β-Wnt/β-Catenin Signaling in Sjögren’s Syndrome Related Dry Eye Open Access

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Bowen Wang; Lihong Liang; Hao Zeng; Xue Yang; Runze Zhang; Wenrui Deng; Xiaoran Wang; Jin Yuan

Tags: conjunctiva, dry eye syndromes, keratinocytes, sequence analysis, rna, signal transduction

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 43. doi:https://doi.org/10.1167/iovs.66.4.43

Application of Metagenomic Long-Read Sequencing for the Diagnosis of Herpetic Uveitis Open Access

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Yoshito Koyanagi; Ai Fujita Sajiki; Kenya Yuki; Hiroaki Ushida; Kenichi Kawano; Kosuke Fujita; Hideyuki Shimizu; Daishi Okuda; Mitsuki Kosaka; Kazuhisa Yamada; Ayana Suzumura; Shu Kachi; Hiroki Kaneko; Hiroyuki Komatsu; Yoshihiko Usui; Hiroshi Goto; Koji M. Nishiguchi

Tags: reading (activity), uveitis, metagenomic sequencing, nanopores, fluid flow

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 50. doi:https://doi.org/10.1167/iovs.66.4.50

RNA-Sequencing Reveals the Modulation of the NLRP3 Inflammasome by miR-223-3p in Extracellular Vesicles in Bacterial Endophthalmitis Open Access

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Dhanwini Rudraprasad; Jayabalan Nirmal; Dilip Kumar Mishra; Joveeta Joseph

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 53. doi:https://doi.org/10.1167/iovs.66.4.53

Lens

In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation Open Access

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Le Chang; Fen Song; Shijia Qu; Huazheng Cao; Yanan Wu; Lulu Xu; Jing Wang; Ruirui Zhang; Chao Xue; Yan Wang

Tags: cell nucleus, eye, lens (device), lens, crystalline, myopia

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 6. doi:https://doi.org/10.1167/iovs.66.4.6

Elevated Inflammatory Cytokines Persist in the Aqueous Humor Years After Cataract Surgery Open Access

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Caili Hao; Emily Fan; Zongbo Wei; Kazi Rafsan Radeen; Neha Purohit; Kailin Li; Sharad Purohit; Xingjun Fan

Tags: cataract, cataract surgery, chronic inflammation, cytokine, hypertension

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 12. doi:https://doi.org/10.1167/iovs.66.4.12

Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens Epithelium and Fibers Open Access

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Matthieu Duot; Sarah Y. Coomson; Sanjaya K. Shrestha; M. V. Murali Krishna Nagulla; Yann Audic; Ruteja A. Barve; Hongzhan Huang; Carole Gautier-Courteille; Luc Paillard; Salil A. Lachke

Tags: datasets, embryo, epithelium, genes, lens epithelium

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 42. doi:https://doi.org/10.1167/iovs.66.4.42

Multidisciplinary Ophthalmic Imaging

A Narrowband 635 nm Autofluorescence Peak in Albino Mouse Eyes Found With Multi-Modal Imaging Reveals the Presence of Protoporphyrin IX in the Choroid Open Access

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Pengfei Zhang; Suman K. Manna; Mayank Goswami; Robert J. Zawadzki; Edward N. Pugh, Jr

Tags: albinism, autofluorescence, diagnostic imaging, eye, mice

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 29. doi:https://doi.org/10.1167/iovs.66.4.29

Retina

Volumetric Measures of Capillary Nonperfusion on Optical Coherence Tomography Angiography Detect Early Ischemia in Diabetes Without Retinopathy Open Access

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Janice X. Ong; Hunter J. Lee; Nicole L. Decker; Daniela Castellanos-Canales; Hisashi Fukuyama; Amani A. Fawzi

Tags: angiogram, blood capillaries, diabetes mellitus, diabetes mellitus, type 2, ischemia

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 2. doi:https://doi.org/10.1167/iovs.66.4.2

Phenotypic and Genotypic Characterization of RP1L1-Associated Retinopathy Open Access

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Alessio Antropoli; Lorenzo Bianco; Xavier Zanlonghi; Amine Benadji; Christel Condroyer; Aline Antonio; Julien Navarro; Claire-Marie Dhaenens; José-Alain Sahel; Christina Zeitz; Isabelle Audo

Tags: atypical, genotype, phenotype, retinal diseases, retinitis pigmentosa

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 7. doi:https://doi.org/10.1167/iovs.66.4.7

Evaluating the Volume of Eyes With Pathologic Myopia Using 3D MRI Open Access

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Tomonari Takahashi; Tae Yokoi-Igarashi; Hiroyuki Takahashi; Noriko Nakao; Kengo Uramoto; Takeshi Yoshida; Muka Moriyama; Koju Kamoi; Koichiro Kimura; Ukihide Tateishi; Kyoko Ohno-Matsui

Tags: 3d mri, eye, volume, shape, staphyloma

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 13. doi:https://doi.org/10.1167/iovs.66.4.13

Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis Open Access

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Shanshan Zhu; Lusi Zhang; Ping Tong; Jiawei Chen; Cong Wang; Zewei Wang; Jingyuan Liu; Peiyun Duan; Qian Jiang; Yubing Zhou; Guangshuang Tan; Xian Zhang; Bing Jiang

Tags: dna, niacinamide, pyroptosis, retinal degeneration, retina

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 14. doi:https://doi.org/10.1167/iovs.66.4.14

Fecal Microbial Profiles and Short-Chain Fatty Acid/Bile Acid Metabolomics in Patients With Age-Related Macular Degeneration: A Pilot Study Open Access

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Zaid Parekh; Jason Xiao; Amir Mani; Quadis Evans; Christopher Phung; Hugo A. Barba; Bingqing Xie; Ashley M. Sidebottom; Anitha Sundararajan; Huaiying Lin; Ramanujam Ramaswamy; David Dao; Reem Gonnah; Madeleine Yehia; Seenu M. Hariprasad; Mark D'Souza; Dinanath Sulakhe; Eugene B. Chang; Dimitra Skondra

Tags: age-related macular degeneration, bile acids, feces, metabolites, metabolomics

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 21. doi:https://doi.org/10.1167/iovs.66.4.21

Nonperfused Retinal Capillaries—A New Method Developed on OCT and OCTA Open Access

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Min Gao; Yukun Guo; Tristan T. Hormel; Jie Wang; Elizabeth White; Dong-Wouk Park; Thomas S. Hwang; Steven T. Bailey; Yali Jia

Tags: biological markers, blood capillaries, diagnostic imaging, eye, face

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 22. doi:https://doi.org/10.1167/iovs.66.4.22

Three-Dimensional Characteristics of Choroidal Vasculature Associated With Filling Delay in Central Serous Chorioretinopathy Open Access

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Tetsuju Sekiryu; Yukinori Sugano; Kanako Itagaki; Junichiro Honjo; Yutaka Kato; Ryo Mukai

Tags: central serous chorioretinopathy, vasculature

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 33. doi:https://doi.org/10.1167/iovs.66.4.33

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1^R213W Mouse Model Open Access

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Xing Wei; Sisi Ma; Yunyu Zhou; Haoliang Cui; Shan Zhang; Duanyang Wang; Yingying Fu; Wei Li; Huihui Han; Yamei Li; Wuyi Li; Huixin Liu; Zixi Sun; Xiaoxu Han; Xuan Zou; Hui Li; Cheng Wang; Ruifang Sui

Tags: electroretinography, mice, gene therapy, capsid

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 37. doi:https://doi.org/10.1167/iovs.66.4.37

Visual Neuroscience

Enlarged Blind Spot Linked to Gamma Zone and Peripapillary Hyperreflective Ovoid Mass-Like Structures in Non-Pathological Highly Myopic Eyes Open Access

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Qiuyan Wu; Ruihan Hu; Qihong Liu; Fang Li; Yuanyuan Wang; Zuohuizi Yi; Jiajia Yuan; Yilei Shao; Meixiao Shen; Hongmei Zheng; Changzheng Chen

Tags: eye, retinal blind spot, glaucoma, myopia

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 5. doi:https://doi.org/10.1167/iovs.66.4.5

Astrocyte-Derived Extracellular Vesicles Alleviate Optic Nerve Injury Through Remodeling of Retinal Microenvironmental Homeostasis Open Access

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Lili Chen; Zhonghao Yu; Senmiao Zhu; Shihan Song; Guanwen He; Zai-Long Chi; Wencan Wu

Tags: astrocytes, extracellular vesicles, micrornas, optic nerve injuries, rna, messenger

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 16. doi:https://doi.org/10.1167/iovs.66.4.16

Depth-Related Visuomotor Performance in Keratoconus and Its Relationship to Stereopsis Open Access

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Preetirupa Devi; Christa M. Bhengra; Deepak Kumar; Rashmi Deshmukh; Pravin K. Vaddavalli; Joshua A. Solomon; Christopher W. Tyler; Shrikant R. Bharadwaj

Tags: depth perception, keratoconus, task performance and analysis, vision, contact lenses

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 31. doi:https://doi.org/10.1167/iovs.66.4.31

Fetal Growth Restriction Is Associated With Altered Optic Nerve Head Morphology in Term-Born Children and Adolescents Open Access

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Achim Fieß; Sandra Gißler; Stephanie Grabitz; Esther M. Hoffmann; Eva Mildenberger; Timo Uphaus; Marianne Hahn; Norbert Pfeiffer; Alica Hartmann; Alexander K. Schuster

Tags: adolescent, child, fetal growth retardation, language morphology, morphology

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 35. doi:https://doi.org/10.1167/iovs.66.4.35

TUT7-Mediated Uridine Degradation of MCPIP1 in the Pterygium to Regulate TRAF6-Mediated Autophagy Open Access

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Juanjuan Li; Hao Ji; Yanze Xu; Weijia Zhang; Yuru Yin; Yubing Zhao; Yan Du; Anni He; Dandan Zhao

Tags: autophagy, pterygium, fibroblasts, rna, messenger, proteins

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 41. doi:https://doi.org/10.1167/iovs.66.4.41

Visual Psychophysics and Physiological Optics

Arabic Reading Performance With a Chromatic Acuity Chart Open Access

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Balsam Alabdulkader; Ali Almustanyir; Norah Alsalem; Essam Almutleb; Mosaad Alhassan; Jeffery K. Hovis

Tags: arabic, reading (activity), luminance, color

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 3. doi:https://doi.org/10.1167/iovs.66.4.3

Directional Motion Sensitivity in Visual Snow Syndrome and Its Relation to Trailing-Type Palinopsia Open Access

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Tatiana S. Obukhova; Tatiana A. Stroganova; Ada R. Artemenko; Anastasiia V. Petrokovskaia; Elena V. Orekhova

Tags: motion, palinopsia, snow - weather, syndrome

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 24. doi:https://doi.org/10.1167/iovs.66.4.24

Multidimensional Functional Phenotyping Based on Photoreceptor-Directed Temporal Contrast Sensitivity Defects in Inherited Retinal Diseases Open Access

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Cord Huchzermeyer; Katarina Stingl; Jan Kremers

Tags: contrast sensitivity, mandibulofacial dysostosis, phenotype determination, photoreceptors, retinal diseases

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 25. doi:https://doi.org/10.1167/iovs.66.4.25

Temporal Contour Integration Deficits in Children With Amblyopia Open Access

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Yan-Ru Chen; Shu-Qi Jiang; Xiang-Yun Liu; Jun-Yun Zhang

Tags: amblyopia, child

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 27. doi:https://doi.org/10.1167/iovs.66.4.27

The Relationship Between Binocular Imbalance and Myopic Shift in Unoperated Eyes After Unilateral SMILE and tPRK Open Access

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Kaiyan Huang; Mi Xia; Qianwen Gong; Kexin Li; Yijie Xu; Hui Wang; Yuzhou Wang; Jiawei Zhou; Liang Hu

Tags: eye, imbalance, spatial frequency

Investigative Ophthalmology & Visual Science April 2025, Vol.66, 32. doi:https://doi.org/10.1167/iovs.66.4.32

Erratum

Erratum in: Porcine Sub-Retinal Pigment Epithelium Deposits: A Model for Dry Age-Related Macular Degeneration With Comparison to Human Drusen Open Access

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Investigative Ophthalmology & Visual Science April 2025, Vol.66, 10. doi:https://doi.org/10.1167/iovs.66.4.10

Erratum in: Dioleoylphosphatidylglycerol Accelerates Corneal Epithelial Wound Healing Open Access

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Investigative Ophthalmology & Visual Science April 2025, Vol.66, 11. doi:https://doi.org/10.1167/iovs.66.4.11

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