Current Issue | IOVS | ARVO Journals

Biochemistry and Molecular Biology

Elastin as a Novel Extracellular Matrix From Aberrant HDAC4 Expression in PDGF-BB-Induced Orbital Fibroblasts From Graves' Ophthalmopathy Patients Open Access

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Rajit Chompoowong; Jutamas Wongphoom; Nakarin Kitkumthorn; Preamjit Saonanon; Vannakorn Pruksakorn; Tanapat Palaga; Nattiya Hirankarn; P. Martin van Hagen; Willem A. Dik; Sita Virakul

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 30. doi:https://doi.org/10.1167/iovs.66.9.30

Clinical and Epidemiologic Research

Growth Curve for Infant's “Fixation To Light” Using Gaze Reaction Time Open Access

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Monika Thakur; Ranindita Saha; Krishnaveni Nagarajan; Murali Murugavel; Himabindu Singh; PremNandhini Satgunam

Tags: gaze, infant, reaction time

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 26. doi:https://doi.org/10.1167/iovs.66.9.26

Interocular Differences in Retinal Curvature in Anisometropic Patients and Their Association With Myopic Degree Differences Open Access

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Gongpeng Sun; Muga Emu; Rong Lin; Jing Gong; Ling Zhao; Chunyan Lei; Bi Yang; Ke Ma; Meixia Zhang

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 31. doi:https://doi.org/10.1167/iovs.66.9.31

Cornea

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway Open Access

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Elwin D. Clutter; Wending Yang; Jacob Han; Nihal Kaplan; Han Peng

Tags: akt signaling pathway, cell motility, dna, epithelial cells, proto-oncogene proteins c-akt

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 2. doi:https://doi.org/10.1167/iovs.66.9.2

DJ-1 Promotes Diabetic Corneal Epithelial Wound Healing by Attenuating Hyperglycemia-Induced Oxidative Stress Through Inhibiting PTEN Open Access

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Haoyu Li; Hanhan Peng; Benteng Ma; Xinyue Sun; Liwei Zhang; Baihua Chen

Tags: cornea, diabetes mellitus, epithelium, hyperglycemia, oxidative stress

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 20. doi:https://doi.org/10.1167/iovs.66.9.20

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Axial Length Dynamics and Safety of Occlusion Therapy in Pediatric Amblyopia: A Longitudinal Analysis Open Access

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Wentong Yu; Yunsi He; Xuan Qiu; Ying Yao; Qingqing Ye; Lei Feng; Zixuan Xu; Yusong Zhou; Yangfei Pang; Yudan Zhong; Qiuying Li; Junpeng Yuan; Yun Wen; Jinrong Li

Tags: amblyopia, amblyopia, pediatric, duration of treatment, eye, occlusion therapy

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 12. doi:https://doi.org/10.1167/iovs.66.9.12

Disrupted Motor Neuron and Neuromuscular Junction Development in an Albino Mice Model of Infantile Nystagmus Open Access

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Sampath Vemula; Abdikheyre Osman; Xiguang Yang; Gabriel Aronchik; Mayra Martinez Sanchez; Nafiza Meher; Mary C. Whitman

Tags: albinism, mice, pathologic nystagmus

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 25. doi:https://doi.org/10.1167/iovs.66.9.25

Genetics

A Phenotypic Study of CRB1 Retinopathy Secondary to the Variant p.(Pro836Thr) Prevalent in Those of Black African Ancestry Open Access

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Wendy M. Wong; Anthony G. Robson; Rebecca A. Baker; Gavin Arno; Joseph Van Aerschot; Siying Lin; Mariya Moosajee; Michel Michaelides; Omar A. Mahroo; Andrew R. Webster

Tags: phenotype, retinal diseases, electroretinography, retinal dystrophies

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 3. doi:https://doi.org/10.1167/iovs.66.9.3

Quantitative Choroidal Analysis of Molecularly Characterized Retinitis Pigmentosa Open Access

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Kirk A. J. Stephenson; Tiffany Tse; Jiwon Hwang; Andrii Kavetskyi; Shanil R. Dhanji; Olubayo U. Kolawole; Cheryl Y. Gregory-Evans; Kaivon Pakzad-Vaezi; Zaid N. Mammo; Kevin Gregory-Evans; Myeong Jin Ju

Tags: cardiovascular imaging, cortical blindness, eye, genotype, retinitis pigmentosa

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 11. doi:https://doi.org/10.1167/iovs.66.9.11

FOXP4 Variants Are Associated With Plateau Iris and Angle Closure Glaucoma Open Access

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William Presley; Su Qing Wang; Bin Guan; Seong Hoon Jeong; Chelsea Bender; Erika Ward; Kayla Johnson; Bridget Blevins; Natalie Michaels; Manjool Shah; Sayoko E. Moroi; Robert B. Hufnagel; Julia E. Richards; Lev Prasov

Tags: angle closure glaucoma, genetics, plateau iris, proteins, glaucoma

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 23. doi:https://doi.org/10.1167/iovs.66.9.23

Glaucoma

Polygenic Risk Prediction for Normal-Tension Glaucoma Open Access

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Maryam Marzban; Santiago Diaz Torres; Regina Yu; Weixiong He; David A. Mackey; Ayellet V. Segrè; Janey Wiggs; Stuart MacGregor; Puya Gharahkhani; on behalf of the International Glaucoma Genetics Consortium

Tags: datasets, low tension glaucoma, polygenic risk score, genome-wide association study

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 4. doi:https://doi.org/10.1167/iovs.66.9.4

The Effect of Carotid Atherosclerosis on the Risk for Open-Angle Glaucoma Open Access

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Victor A. de Vries; Karin A. van Garderen; Caroline C. W. Klaver; Daniel Bos; Maryam Kavousi; Wishal D. Ramdas

Tags: carotid atherosclerosis, carotid intima-media thickness, glaucoma, open-angle glaucoma, intraocular pressure

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 9. doi:https://doi.org/10.1167/iovs.66.9.9

Natural Course and Risk Factors of Glaucoma Development in the Untreated Fellow Eye in Unilateral Normal-Tension Glaucoma Open Access

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Eun Jung Lee; Do Young Park; Changwon Kee; Jong Chul Han

Tags: did not receive therapy or drug, eye, glaucoma, intraocular pressure, low tension glaucoma

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 16. doi:https://doi.org/10.1167/iovs.66.9.16

Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length Open Access

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Tingting Liu; Ya Xing Wang; Jost B. Jonas; Quan V. Hoang; Michaël J. A. Girard; Xiaofei Wang

Tags: eye, gaze, myopia, optic disk, eye movement

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 21. doi:https://doi.org/10.1167/iovs.66.9.21

Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization Open Access

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Victor A. de Vries; Anita Szabo; Joëlle E. Vergroesen; Siyin Liu; Karin A. van Garderen; Kirithika Muthusamy; Petra Liskova; Lubica Dudakova; Anthony P. Khawaja; Stephen J. Tuft; Caroline C. W. Klaver; Alice E. Davidson; Wishal D. Ramdas

Tags: cardiac ct, cohort studies, cornea, glaucoma, mendelian randomization analysis

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 22. doi:https://doi.org/10.1167/iovs.66.9.22

Immunology and Microbiology

The Gut Microbial System Responds to Retinal Injury and Modulates the Outcomes by Regulating Innate Immune Activation Open Access

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Xuexue Cui; Caijiao Yi; Jian Liu; Jinyan Qi; Wen Deng; Xiangling Yuan; Ruiqi Zhou; Mei Chen; Qiang Xiang; Heping Xu

Tags: antibiotics, gastrointestinal microbiome, mice, retinal injuries, wounds and injuries

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 6. doi:https://doi.org/10.1167/iovs.66.9.6

Lens

Transcriptomic Analysis of Human Lens Epithelium Tissue With and Without Cataract Surgery: Uncovering Novel Pathways of Post-Surgical Lens Epithelium Remodeling Open Access

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Caili Hao; Kailin Li; Zongbo Wei; Kazi Rafsan Radeen; Xiang Zhang; Sharad Purohit; Xingjun Fan

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 28. doi:https://doi.org/10.1167/iovs.66.9.28

Multidisciplinary Ophthalmic Imaging

Superficial Retinal Intercapillary Oxygen Diffusion and Perfusion Deficit Alterations in Patients With Coronary Artery Disease Open Access

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Natasa Jeremic; Meltem Esengönül; Azin Zarghami; Maximilian Pawloff; Matthias Hasun; Markus Schreiner; Reinhard Windhager; Alexander Niessner; Andreas Pollreisz; Hrvoje Bogunovic; Ursula Schmidt-Erfurth

Tags: coronary arteriosclerosis, oxygen diffusion, perfusion, comorbidity, artifacts

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 27. doi:https://doi.org/10.1167/iovs.66.9.27

Retina

Fundus Refraction Offset as a Personalized Biomarker for 12-Year Risk of Retinal Detachment Open Access

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Fabian Yii; Ian J. C. MacCormick; Niall Strang; Miguel O. Bernabeu; Tom MacGillivray

Tags: biological markers, refraction, retinal detachment, eye, medical history

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 1. doi:https://doi.org/10.1167/iovs.66.9.1

Retinal Angiogenesis in Methamphetamine Self-Administration Rats Open Access

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Minsup Lee; Bo J. Wood; Hyeon Hak Jeong; Hyung W. Nam; Courtney M. Keller; Bonggi Lee; Jae-Il Kim; Kevin S. Murnane; Nicholas E. Goeders; Norman R. Harris

Tags: angiogenesis, methamphetamine, rats, self administration, retina

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 8. doi:https://doi.org/10.1167/iovs.66.9.8

Diabetes-Induced Dysregulation of Peripapillary and Macular Neurovascular Units Open Access

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Mizuho Mitamura; Satoru Kase; Hiroaki Endo; Michiyuki Saito; Satoshi Katsuta; Susumu Ishida

Tags: diabetes mellitus, diabetes mellitus, type 2, eye, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 10. doi:https://doi.org/10.1167/iovs.66.9.10

Hyperreflective Foci in the Ectopic Inner Foveal Layer of Advanced Idiopathic Epiretinal Membranes Open Access

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Nicola Valsecchi; Maurizio Mete; Giulio Rapezzi; Matteo Elifani; Giulia Folgaria; Alessandro Finzi; Antonio Moramarco; Luigi Fontana

Tags: epiretinal membrane, eye, heart failure, surgical procedures, operative, postoperative care

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 14. doi:https://doi.org/10.1167/iovs.66.9.14

Choroidal Features of Cynomolgus Macaques in Relation to Age and Axial Length Open Access

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Guitong Ye; Yuan Zhang; Shaofen Huang; Jinan Zhan; Ruiyu Luo; Rui Xie; Yuyao Ling; Ye Deng; Caibin Deng; Wei Liu; Zhiwei Huang; Chusheng Zhang; Junshu Wu; Zhidong Li; Yehong Zhuo

Tags: cardiovascular imaging, choroid, cortical blindness, macaca, macaca fascicularis

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 17. doi:https://doi.org/10.1167/iovs.66.9.17

In Vivo Characterization of Bruch’s Membrane Breaks in Neovascular Age-Related Macular Degeneration Using High-Resolution Optical Coherence Tomography Open Access

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Mai Alhelaly; Ceren Soylu; Giulia Corradetti; Federico Corvi; Alireza Mahmoudi; Rouzbeh Abbasgholizadeh; Giovanni Bellisario; Ye He; Alberto Quarta; Muneeswar G. Nittala; Giovanni Staurenghi; SriniVas R. Sadda

Tags: bruch's basal membrane, exudative age-related macular degeneration, eye, macular neovascularization, optical coherence tomography

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 19. doi:https://doi.org/10.1167/iovs.66.9.19

Exosomal miRNA Profiling in Liquid Biopsy of Vitreous in Proliferative Diabetic Retinopathy Open Access

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Bin Yan; Jianing Qiu; Yan Yang; Jing Luo; Dan Liu; Lusi Zhang; Zhishang Meng; Huiling Li; Xiaojian Guo; Jun Zeng; Chun Ding; Manyun Xie; Kejun Long

Tags: micrornas, vitreous body, proliferative diabetic retinopathy, liquid biopsy, exosomes

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 24. doi:https://doi.org/10.1167/iovs.66.9.24

Early Photoreceptor Alterations After Retinal Detachment Repair Open Access

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Sandrine H. Sassen; Josua Sassen; Marlene Sassmannshausen; Lukas Goerdt; Yannick Liermann; Raffael G. Liegl; Philipp Herrmann; Robert P. Finger; Frank G. Holz; Sarah Thiele

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 32. doi:https://doi.org/10.1167/iovs.66.9.32

Retinal Cell Biology

Activation of Sigma 1 Receptor Preserves Visual Function After Optic Nerve Injury Open Access

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Jing Wang; Zhimin Xu; Ruth Caldwell

Tags: mice, optic nerve injuries, retina, vision, wounds and injuries

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 13. doi:https://doi.org/10.1167/iovs.66.9.13

Intravenous Sodium Iodate Administration Induces Macula-Specific RPE Damage and Rod-Dominant Apoptosis in the Cynomolgus Monkey Open Access

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Shoji Notomi; Guannan Wu; Takaharu Nagaoka; Nao Yotsumoto; Tomoaki Araki; Mitsuru Arima; Toshio Hisatomi; Koh-Hei Sonoda; Kazutoshi Sawada

Tags: apoptosis, cercopithecidae, iodates, macaca fascicularis, macula lutea

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 18. doi:https://doi.org/10.1167/iovs.66.9.18

Visual Neuroscience

Evidence for M₂ Muscarinic Receptor Antagonist Delay of Myopia Development Through Activation of Kir3.4 Channel in the Retina of Guinea Pigs Open Access

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Hong Zhou; Guimei Zhou; Qin Yang; Jiahao Niu; Runzhe Wang; Huilan Liu; Suwen Hou; Hongsheng Bi; Xuan Liao

Tags: antagonists, caviidae, muscarinic acetylcholine receptor, myopia, retina

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 5. doi:https://doi.org/10.1167/iovs.66.9.5

Visual Psychophysics and Physiological Optics

The Effects of Refractive Imbalance on Binocular Vision Status, Reading Performance, and Vision-Related Reading Difficulty Symptoms in Expert Readers Open Access

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Taehwan Lee; Myra Leung; Jeroen J. A. van Boxtel; Mei Ying Boon

Tags: imbalance, reading (activity), reading difficulties, signs and symptoms, vision

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 15. doi:https://doi.org/10.1167/iovs.66.9.15

Relative Role of ON/OFF Pathways in Resolving and Adapting to Blur in Myopes and Emmetropes Open Access

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Hosein Hoseini-Yazdi; Andrew Carkeet; Rida Ahmed; Faaizah Ali; Julia Anderson; Zhi Yu Chan; Jade Chng; Nitansha Nand; Anh Pham; Hannah Soen; Leeanne Su; Mandy Truong; Scott A. Read

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 29. doi:https://doi.org/10.1167/iovs.66.9.29

Erratum

Erratum in: Assessment of Neuroprotective Effects of Glutamate Modulation on Glaucoma-Related Retinal Ganglion Cell Apoptosis In Vivo Open Access

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Investigative Ophthalmology & Visual Science July 2025, Vol.66, 33. doi:https://doi.org/10.1167/iovs.66.9.33

Expression of Concern

Expression of Concern for: Assessment of Neuroprotective Effects of Glutamate Modulation on Glaucoma-Related Retinal Ganglion Cell Apoptosis In Vivo Open Access

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Investigative Ophthalmology & Visual Science July 2025, Vol.66, 34. doi:https://doi.org/10.1167/iovs.66.9.34

Expression of Concern for: Retinal Ganglion Cell Apoptosis in Glaucoma Is Related to Intraocular Pressure and IOP-Induced Effects on Extracellular Matrix Open Access

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Investigative Ophthalmology & Visual Science July 2025, Vol.66, 35. doi:https://doi.org/10.1167/iovs.66.9.35

Special Issue

IMI—Instrumentation for Myopia Management Open Access

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Deborah Jones; Amy Chow; Daddi Fadel; Jose Manuel Gonzalez Meijome; Andrzej Grzybowski; Pete Kollbaum; James Loughman; James Wolffsohn

Tags: myopia, surgical instruments, optics

Investigative Ophthalmology & Visual Science July 2025, Vol.66, 7. doi:https://doi.org/10.1167/iovs.66.9.7

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