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Physiology and Pharmacology October 2024

Comprehensive Pharmacokinetic Evaluation of High Melanin Binder Levofloxacin in Rabbits Shows Potential of Topical Eye Drops for Posterior Segment Treatment

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Sina Bahrpeyma; Paulina Jakubiak; Rubén Alvarez-Sánchez; Antonello Caruso; Monika Leuthardt; Claudia Senn; Eva M. del Amo; Arto Urtti
TAGS: body tissue, drug delivery, targeted, eyedrops, levofloxacin, melanins, oryctolagus cuniculus, albinism, multiple-dose regimen
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):14. https://doi.org/10.1167/iovs.65.12.14

Includes: Supplemental Content

Review September 2024

Mathematical Models of Ocular Drug Delivery

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Amir Sadeghi; Astrid Subrizi; Eva M. del Amo; Arto Urtti
TAGS: aqueous humor, body tissue, drug delivery systems, eye, mathematical model, vitreous body, drug concentration, mass or substance concentration per volume, intravitreal injections, molecule
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):28. https://doi.org/10.1167/iovs.65.11.28

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Safety, Tolerability & Pharmacokinetics of Sustained Release Latanoprost (LAT) From Intravitreal Injection of a Semi-Solid in-situ Forming Implant

Harri Jari Jukarainen; Jukka Tuominen; Vinod Vijayakumar; Elisa Toropainen; Arto Urtti; Hari Jayaraman; Eva Del Amo; Juuso Paterno; Annika Valtari; Marika Ruponen; Amir Sadeghi; Jooseppi Puranen; Kati-Sisko Vellonen

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3981.

ARVO Annual Meeting Abstract June 2024

Rabbit eye mimicking in vitro model for intravitreal drug release studies

Teemu Ilmari Sorsa; Iuliia Pilipenko; Astrid Subrizi; Arto Urtti

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3964.

ARVO Annual Meeting Abstract June 2024

Permeability of 13 small molecular weight compounds through ex vivo rabbit ocular tissues

Jonna Laitinen; Kati-Sisko Vellonen; Arto Urtti; Astrid Subrizi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3963.

ARVO Annual Meeting Abstract June 2023

Pharmacokinetics and Modeling of Intravitreal Levofloxacin in Pigmented and Albino Rabbits Eyes

Sina Bahrpeyma; Paulina Jakubiak; Eva M. Del Amo; Antonello Caruso; Arto Urtti

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2413.

ARVO Annual Meeting Abstract June 2021

Anti-inflammatory medication after corneal trauma or surgery to prevent subsequent late glaucoma.

Eleftherios I Paschalis; Chengxin Zhou; Fengyang Lei; Sarah Kim; Demetrios G. Vavvas; James Chodosh; Arto Urtti; George Papaliodis; Claes H Dohlman

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):891.

Physiology and Pharmacology December 2019

Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters

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Laura Hellinen; Kazuki Sato; Mika Reinisalo; Heidi Kidron; Kirsi Rilla; Masanori Tachikawa; Yasuo Uchida; Tetsuya Terasaki; Arto Urtti
TAGS: carrier proteins, cell membrane, membrane transport proteins, proteins, tissue membrane, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2019; 60(15):5022-5034. https://doi.org/10.1167/iovs.19-27328

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Lipidoid-siRNA formulations promote gene silencing in differentiated and non-dividing ARPE-19, primary porcine and human embryonic stem cell-derived retinal pigment epithelial cells

Astrid Subrizi; Chuanxu Yang; Tanja Ilmarinen; Heli Skottman; Arto Urtti; Jørgen Kjems

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5685.

ARVO Annual Meeting Abstract July 2018

Synaptic coupling of unmyelinated optic nerve axons – a novel insight into optic nerve structure and conductivity properties

Adrian Smedowski; Saeed Akhtar; Lucia Podracka; Xiaonan Liu; Elisa Toropainen; Marialaura Amadio; Marita Pietrucha-Dutczak; Markku Varjosalo; Arto Urtti; Kai Kaarniranta; Joanna Lewin-Kowalik

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):313.

ARVO Annual Meeting Abstract September 2016

Drug distribution to retinal pigment epithelium: studies on melanin binding, cellular kinetics and SPECT/CT imaging

Anna-Kaisa Rimpelä; Mechthild Schmitt; Satu Latonen; Marja Hagström; Maxim Antopolsky; José Antonio Manzanares; Heidi Kidron; Arto Urtti

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):107.

ARVO Annual Meeting Abstract September 2016

Computational Prediction of Intravitreal Pharmacokinetics of Macromolecules: Tool for Ocular Drug Development

Eva María del Amo Páez; Arto Urtti

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):291.

ARVO Annual Meeting Abstract September 2016

In vivo protection of degenerating cones in the cpfl1 mouse by HDAC inhibition

Dragana Trifunovic; Anotella Comitato; Blanca Arango-Gonzalez; Melanie Barth; Eva María del Amo Páez; Arto Urtti; Yvan Arsenijevic; Marius Ueffing; Valeria Marigo; Francois Paquet-Durand

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4393.

ARVO Annual Meeting Abstract April 2014

Polyesteramide Microspheres As Carriers In Ophthalmology. In Vitro Toxicity In Macrophages, ARPE-19 Cells And An Organotypic Culture Of Retina

Vanessa Andres-Guerrero; Blanca Arango-Gonzalez; Eva Ramsay; Mengmeng Zong; Beatriz de las Heras; George Mihov; Aylvin Dias; Arto Urtti; Marius Ueffing; Rocio Herrero-Vanrell

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4900.

ARVO Annual Meeting Abstract June 2013

In vitro cytotoxicity screening and pharmacokinetic modeling: a tool in the development of ocular drug delivery systems

Eva Tuominen; George Mihov; Mengmeng Zong; Sanjay Sarkhel; Aylvin Dias; Arto Urtti

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):5065.

ARVO Annual Meeting Abstract April 2010

Kinetic Simulation of Active Drug Transport in the Cornea

K.-S. Vellonen; E. Järvinen; A. Urtti

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):696.

ARVO Annual Meeting Abstract April 2010

Non-Viral Gene Therapy and Retinal Pigment Epithelium Tissue Engineering for the Treatment of Age-Related Macular Degeneration

A. Subrizi; S. Van Vlierberghe; G. Subra; M. Amblard; J. Martinez; E. Schacht; P. Dubruel; M. Yliperttula; A. Urtti

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):4496.

Glaucoma May 2009

The Effects of 5-Fluorouracil on Ocular Tissues In Vitro and In Vivo after Controlled Release from a Multifunctional Implant

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Anne Huhtala; Seppo Rönkkö; Markku Teräsvirta; Tuomo Puustjärvi; Roope Sihvola; Katja Vehanen; Antti Laukkanen; Johanna Anttila; Arto Urtti; Timo Pohjonen; Hannu Uusitalo
TAGS: fluorouracil, implants, body tissue
Invest. Ophthalmol. Vis. Sci.. 2009; 50(5):2216-2223. https://doi.org/10.1167/iovs.08-3016

ARVO Annual Meeting Abstract April 2009

Barriers of Sclera, Chorioidea and Rpe in Periocular Drug Delivery: A Simulation Study

A. Urtti; E. Mannermaa; N. Valkonen; V.-P. Ranta

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):5973.

ARVO Annual Meeting Abstract May 2008

A System and Method for Recording the Eye and Brain Visual Responses From Conscious Animals

A. J. Valjakka; J. Ahonen; L. Pitkanen; A. Urtti

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):4498.

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Comprehensive Pharmacokinetic Evaluation of High Melanin Binder Levofloxacin in Rabbits Shows Potential of Topical Eye Drops for Posterior Segment Treatment

Mathematical Models of Ocular Drug Delivery

Safety, Tolerability & Pharmacokinetics of Sustained Release Latanoprost (LAT) From Intravitreal Injection of a Semi-Solid in-situ Forming Implant

Rabbit eye mimicking in vitro model for intravitreal drug release studies

Permeability of 13 small molecular weight compounds through ex vivo rabbit ocular tissues

Pharmacokinetics and Modeling of Intravitreal Levofloxacin in Pigmented and Albino Rabbits Eyes

Anti-inflammatory medication after corneal trauma or surgery to prevent subsequent late glaucoma.

Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters

Lipidoid-siRNA formulations promote gene silencing in differentiated and non-dividing ARPE-19, primary porcine and human embryonic stem cell-derived retinal pigment epithelial cells

Synaptic coupling of unmyelinated optic nerve axons – a novel insight into optic nerve structure and conductivity properties

Drug distribution to retinal pigment epithelium: studies on melanin binding, cellular kinetics and SPECT/CT imaging

Computational Prediction of Intravitreal Pharmacokinetics of Macromolecules: Tool for Ocular Drug Development

In vivo protection of degenerating cones in the cpfl1 mouse by HDAC inhibition

Polyesteramide Microspheres As Carriers In Ophthalmology. In Vitro Toxicity In Macrophages, ARPE-19 Cells And An Organotypic Culture Of Retina

In vitro cytotoxicity screening and pharmacokinetic modeling: a tool in the development of ocular drug delivery systems

Kinetic Simulation of Active Drug Transport in the Cornea

Non-Viral Gene Therapy and Retinal Pigment Epithelium Tissue Engineering for the Treatment of Age-Related Macular Degeneration

The Effects of 5-Fluorouracil on Ocular Tissues In Vitro and In Vivo after Controlled Release from a Multifunctional Implant

Barriers of Sclera, Chorioidea and Rpe in Periocular Drug Delivery: A Simulation Study

A System and Method for Recording the Eye and Brain Visual Responses From Conscious Animals

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