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Glaucoma May 2019

Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma

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Gaurang C. Patel; J. Cameron Millar; Abbot F. Clark
TAGS: glaucoma, glucocorticoids, injections, ocular hypertension, glucocorticoid receptors, trans-activation (genetics), intraocular pressure, mice, medication therapy management
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):1967-1978. doi: 10.1167/iovs.18-26383

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Mouse Eye Perfusion In-Vivo Versus Ex-Vivo: Influence on Aqueous Outflow Facility

J Cameron Millar; Navita N Lopez; Urmimala Raychaudhuri; Abbot F. Clark

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1655. doi:

ARVO Annual Meeting Abstract July 2018

TGFβ2 regulates the expression of ECM and associated proteins by modulating miRNAs in human optic nerve head astrocytes and lamina cribrosa cells

Navita Nanda Lopez; Tara Tovar-Vidales; Abbot F. Clark

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3524. doi:

ARVO Annual Meeting Abstract July 2018

High glucose impairs optic nerve head astrocyte phagocytosis prior to retinal ganglion cell degeneration

Yang Liu; Jinzi Wu; Liang-jun Yan; Abbot F. Clark

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3549. doi:

ARVO Annual Meeting Abstract July 2018

Canonical Wnt signaling in optic nerve head

Elliott Allums; Yang Liu; Abbot F. Clark

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3739. doi:

ARVO Annual Meeting Abstract July 2018

Primary Cilia and Extracellular Matrix Interactions in Trabecular Meshwork Cells

Ankur Jain; Wei Zhu; Qihong Zhang; Markus H Kuehn; Abbot F. Clark; Val C. Sheffield

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4721. doi:

ARVO Annual Meeting Abstract July 2018

Glucocorticoid-Induced Ocular Hypertension in Mice Requires Glucocorticoid Receptor Transactivation Activity

Abbot F. Clark; J Cameron Millar; Gaurang Patel

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6037. doi:

ARVO Annual Meeting Abstract July 2018

Novel Ex-Vivo Translaminar Autonomous System to study effects of Intraocular and Intracranial pressure differential on Human Retinal Ganglion Cells.

Tasneem Putliwala Sharma; Abbot F. Clark; Colleen M McDowell

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1214. doi:

Glaucoma April 2018

BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork

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Humberto Hernandez; J. Cameron Millar; Stacy M. Curry; Abbot F. Clark; Colleen M. McDowell
TAGS: extracellular matrix, fibronectins, activins, tissue membrane, ocular hypertension, trabecular meshwork, eye, intraocular pressure, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2154-2166. doi: 10.1167/iovs.17-23282

Includes: Supplemental Content

Glaucoma March 2018

The Role of Wnt/β-Catenin Signaling and K-Cadherin in the Regulation of Intraocular Pressure

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Hannah C. Webber; Jaclyn Y. Bermudez; J. Cameron Millar; Weiming Mao; Abbot F. Clark
TAGS: signal transduction, cadherins, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1454-1466. doi: 10.1167/iovs.17-21964

Includes: Supplemental Content

Glaucoma February 2018

Activation of the NFAT–Calcium Signaling Pathway in Human Lamina Cribrosa Cells in Glaucoma

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Mustapha Irnaten; Alexander Zhdanov; Deirdre Brennan; Thomas Crotty; Abbot Clark; Dmitri Papkovsky; Colm O'Brien
TAGS: hypotonicity, glaucoma, hydrogen peroxide, cyclosporine, signal pathway, cribriform plate, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):831-842. doi: 10.1167/iovs.17-22531

Includes: Supplemental Content

Glaucoma February 2018

Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells

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Baiyun Liu; Jason I. Kilpatrick; Bartlomiej Lukasz; Suzanne P. Jarvis; Fiona McDonnell; Deborah M. Wallace; Abbot F. Clark; Colm J. O'Brien
TAGS: actins, phenotype, fibronectins, glaucoma, cues, vinculin, cribriform plate, myofibroblast
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):803-814. doi: 10.1167/iovs.17-22400

Includes: Multimedia, Supplemental Content

Glaucoma December 2017

Tissue Transglutaminase Elevates Intraocular Pressure in Mice

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Urmimala Raychaudhuri; J. Cameron Millar; Abbot F. Clark
TAGS: body tissue, transglutaminases, eye, intraocular pressure, mice
Invest. Ophthalmol. Vis. Sci.. 2017; 58(14):6197-6211. doi: 10.1167/iovs.17-22236

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Anterior Chamber Versus Posterior Chamber Perfusion Does Not Influence Aqueous Outflow Facility in Living Mice as Measured by Constant Flow Infusion

J Cameron Millar; Navita Nanda Lopez; Gaurang C Patel; Tien Phan; Abbot F Clark

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1061. doi:

ARVO Annual Meeting Abstract June 2017

Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension and glaucoma in mice

Gaurang C Patel; Yang Liu; J Cameron Millar; Abbot F Clark

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):849. doi:

ARVO Annual Meeting Abstract June 2017

Establishment of conditionally immortalized mouse optic nerve astrocyte line

Yang Liu; Gaurang C Patel; Weiming Mao; Abbot F Clark

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2548. doi:

ARVO Annual Meeting Abstract June 2017

Effects of Wnt/beta-catenin and SMAD/TGF-beta crosstalk on cadherins in the trabecular meshwork

Hannah Webber; Weiming Mao; Abbot F Clark

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3488. doi:

ARVO Annual Meeting Abstract June 2017

Tissue transglutaminase mediated ocular hypertension and effects of a small molecule crosslinking modulator

Urmimala Raychaudhuri; J Cameron Millar; Abbot F Clark

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3494. doi:

ARVO Annual Meeting Abstract June 2017

Role of Primary Cilia in Trabecular Meshwork Cell Function

Ankur Jain; Wei Zhu; Qihong Zhang; Markus H Kuehn; Abbot F Clark; Val Sheffield

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3772. doi:

ARVO Annual Meeting Abstract June 2017

Inhibition of Transforming Growth Factor-β2 Signaling Prevents ECM Remodeling, Endoplasmic Reticulum Stress and Ocular Hypertension in Steroid-induced Glaucoma

Ramesh Kasetti; Prabhavathi Maddineni; Pinkal Patel; J Cameron Millar; Tien Phan; Charles C Searby; Abbot F Clark; Val Sheffield; Gulab Zode

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4603. doi:

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Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma

Mouse Eye Perfusion In-Vivo Versus Ex-Vivo: Influence on Aqueous Outflow Facility

TGFβ2 regulates the expression of ECM and associated proteins by modulating miRNAs in human optic nerve head astrocytes and lamina cribrosa cells

High glucose impairs optic nerve head astrocyte phagocytosis prior to retinal ganglion cell degeneration

Canonical Wnt signaling in optic nerve head

Primary Cilia and Extracellular Matrix Interactions in Trabecular Meshwork Cells

Glucocorticoid-Induced Ocular Hypertension in Mice Requires Glucocorticoid Receptor Transactivation Activity

Novel Ex-Vivo Translaminar Autonomous System to study effects of Intraocular and Intracranial pressure differential on Human Retinal Ganglion Cells.

BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork

The Role of Wnt/β-Catenin Signaling and K-Cadherin in the Regulation of Intraocular Pressure

Activation of the NFAT–Calcium Signaling Pathway in Human Lamina Cribrosa Cells in Glaucoma

Increased Substrate Stiffness Elicits a Myofibroblastic Phenotype in Human Lamina Cribrosa Cells

Tissue Transglutaminase Elevates Intraocular Pressure in Mice

Anterior Chamber Versus Posterior Chamber Perfusion Does Not Influence Aqueous Outflow Facility in Living Mice as Measured by Constant Flow Infusion

Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension and glaucoma in mice

Establishment of conditionally immortalized mouse optic nerve astrocyte line

Effects of Wnt/beta-catenin and SMAD/TGF-beta crosstalk on cadherins in the trabecular meshwork

Tissue transglutaminase mediated ocular hypertension and effects of a small molecule crosslinking modulator

Role of Primary Cilia in Trabecular Meshwork Cell Function

Inhibition of Transforming Growth Factor-β2 Signaling Prevents ECM Remodeling, Endoplasmic Reticulum Stress and Ocular Hypertension in Steroid-induced Glaucoma

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