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ARVO Annual Meeting Abstract June 2024

A Phase 1 Trial of Topical Insulin for Patients with Glaucoma

Zac Wennberg Smith; Gala Beykin; Mariella Saludares; Mariana Nunez; QianQian Wang; Adriana Di Polo; Jeffrey Louis Goldberg

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):668.

ARVO Annual Meeting Abstract June 2024

Topical insulin protects against retinal ganglion cell loss in nonhuman primate model of experimental glaucoma

Priya Chaudhary; Trinity Holthausen; Grant Cull; Michaela Dunn; Dawn Jennings; Juan Reynaud; Adriana Di Polo; Brad Fortune

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):667.

ARVO Annual Meeting Abstract June 2024

Islets of Langerhans transplantation into the eye anterior chamber improves retinal ganglion cell function and visual behaviors in glaucoma

Sana El Hajji; Clara Gobault; Yukihiro Shiga; Nicolas Belforte; Melanie Ethier; Isaac Alejandro Vidal Paredes; Florence Dotigny; Vincent Poitout; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):701.

ARVO Annual Meeting Abstract June 2024

Mitochondrial uncoupler MP201 promotes retinal ganglion cell neuroprotection in experimental glaucoma

Heberto Quintero; Renata Ghenno-Manrique; Nicolas Belforte; Jorge L. Cueva-Vargas; Robert Alonso; John G. Geisler; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):670.

ARVO Annual Meeting Abstract June 2024

Restoration of Blood-Retinal Barrier Integrity Prevents Neurodegeneration in Glaucoma

Isaac Alejandro Vidal Paredes; Jorge Luis Cueva Vargas; Nicolas Belforte; Yukihiro Shiga; Florence Dotigny; Heberto Quintero; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):393.

ARVO Annual Meeting Abstract June 2024

Chemogenetic-induced retinal ganglion cell excitation reveals IP3R-dependent dysregulation of calcium dynamics linked to neuronal metabolic stress in glaucoma

Yukihiro Shiga; Jorge Luis Cueva Vargas; Sana El Hajji; Nicolas Belforte; Florence Dotigny; Heberto Quintero; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3253.

ARVO Annual Meeting Abstract June 2024

Single-cell transcriptomics reveals pericyte-glia interactions during neurovascular dysfunction in glaucoma

Deborah Villafranca-Baughman; Gael Louis Max Cagnone; Nicolas Belforte; Jorge Luis Cueva Vargas; Florence Dotigny; Priya Chaudhary; Veronique Lisi; Brad Fortune; Jean-Sebastien Joyal; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4877.

ARVO Annual Meeting Abstract June 2024

Insulin protects against progression of experimental glaucoma (EG) in nonhuman primates (NHP)

Brad Fortune; Michaela Dunn; Grant Cull; Juan Reynaud; Dawn Jennings; Trinity Holthausen; Priya Chaudhary; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):941.

Glaucoma August 2023

Utility of Light-Adapted Full-Field Electroretinogram ON and OFF Responses for Detecting Glaucomatous Functional Damage

PDF

Michaela Dunn; Grant Cull; Juan Reynaud; Dawn Jennings; Trinity Holthausen; Adriana Di Polo; Brad Fortune
TAGS: electroretinography, glaucoma, photopsia, eye
Trans. Vis. Sci. Tech.. 2023; 12(8):16. https://doi.org/10.1167/tvst.12.8.16

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Calcium clearance deficits linked to endoplasmic reticulum stress are signature features of early retinal ganglion cell damage in glaucoma

Yukihiro Shiga; Aline Giselle Rangel Olguin; Sana El Hajji; Nicolas Belforte; Heberto Quintero; Florence Dotigny; Luis Alarcon-Martinez; Arjun Krishnaswamy; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):482.

ARVO Annual Meeting Abstract June 2023

Insulin for retinal ganglion cell regeneration in glaucoma

Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2404.

ARVO Annual Meeting Abstract June 2023

A crosstalk between mTORC1 and mTORC2 is required for full retinal ganglion cell regeneration mediated by insulin

Sana El Hajji; Yukihiro Shiga; Nicolas Belforte; Yves Carpentier Solorio; Olivier Tastet; Philippe D'Onofrio; Florence Dotigny; Alexandre Prat; Brad Fortune; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2839.

ARVO Annual Meeting Abstract June 2023

Glial cells regulate pericyte-driven capillary deficits in glaucoma

Deborah Villafranca-Baughman; Luis Alarcon-Martinez; Nicolas Belforte; Heberto Quintero; Florence Dotigny; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3259.

ARVO Annual Meeting Abstract June 2023

Functional microvascular volume as a proportion of tissue volume is reduced in the RNFL but not the ONH rim at the onset of experimental glaucoma

Michaela Dunn; Juan Reynaud; Grant Cull; Dawn Jennings; Howard Lockwood; Trinity Holthausen; Stuart Keith Gardiner; Ian A Sigal; Claude F Burgoyne; Adriana Di Polo; Brad Fortune

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3779.

ARVO Annual Meeting Abstract June 2023

During progression of glaucomatous damage, the rate of functional microvascular tissue loss exceeds loss of non-vascular tissue within the retinal nerve fiber layer, but declines proportionally within the optic nerve head neuroretinal rim

Brad Fortune; Grant Cull; Michaela Dunn; Dawn Jennings; Howard Lockwood; Trinity Holthausen; Stuart Keith Gardiner; Ian A Sigal; Claude Burgoyne; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3784.

ARVO Annual Meeting Abstract June 2022

Restoration of mitochondrial axonal transport by adaptor supplementation prevents neurodegeneration and rescues visual function in glaucoma

Heberto Quintero; Yukihiro Shiga; Nicolas A Belforte; Luis Alarcon-Martinez; Sana El Hajji; Deborah Villafranca-Baughman; Florence Dotigny; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):12.

ARVO Annual Meeting Abstract June 2022

Autophagy Dysfunction Represses mTORC1 Signaling Resulting in Neurodegeneration of Retinal Ganglion Cells in Glaucoma

Kang-Chieh Huang; Cátia Gomes; Yukihiro Shiga; Kirstin VanderWall; Sailee Sham Lavekar; Clarisse Fligor; Jade Harkin; Adriana Di Polo; Jason S Meyer

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1475.

ARVO Annual Meeting Abstract June 2022

Insulin promotes RGC dendrite regeneration through ribosomal protein S6 kinase activation leading to restoration of neuronal function in glaucoma

Sana El Hajji; Nicolas A Belforte; Yukihiro Shiga; Florence Dotigny; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1137.

ARVO Annual Meeting Abstract June 2022

Light-evoked RGC calcium dynamics are altered in glaucoma: live imaging evidence of abnormal calcium clearance

Yukihiro Shiga; Aline Giselle Rangel Olguin; Luis Alarcon-Martinez; Nicolas A Belforte; Heberto Quintero; Deborah Villafranca-Baughman; Florence Dotigny; Arjun Krishnaswamy; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1850.

ARVO Annual Meeting Abstract June 2022

A novel femtomolar hemodynamic modulation strategy reveals major microvascular defects in glaucoma at single-pericyte scale

Deborah Villafranca-Baughman; Luis Alarcon-Martinez; Jorge Luis Cueva Vargas; Nicolas A Belforte; Florence Dotigny; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3501.

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A Phase 1 Trial of Topical Insulin for Patients with Glaucoma

Topical insulin protects against retinal ganglion cell loss in nonhuman primate model of experimental glaucoma

Islets of Langerhans transplantation into the eye anterior chamber improves retinal ganglion cell function and visual behaviors in glaucoma

Mitochondrial uncoupler MP201 promotes retinal ganglion cell neuroprotection in experimental glaucoma

Restoration of Blood-Retinal Barrier Integrity Prevents Neurodegeneration in Glaucoma

Chemogenetic-induced retinal ganglion cell excitation reveals IP3R-dependent dysregulation of calcium dynamics linked to neuronal metabolic stress in glaucoma

Single-cell transcriptomics reveals pericyte-glia interactions during neurovascular dysfunction in glaucoma

Insulin protects against progression of experimental glaucoma (EG) in nonhuman primates (NHP)

Utility of Light-Adapted Full-Field Electroretinogram ON and OFF Responses for Detecting Glaucomatous Functional Damage

Calcium clearance deficits linked to endoplasmic reticulum stress are signature features of early retinal ganglion cell damage in glaucoma

Insulin for retinal ganglion cell regeneration in glaucoma

A crosstalk between mTORC1 and mTORC2 is required for full retinal ganglion cell regeneration mediated by insulin

Glial cells regulate pericyte-driven capillary deficits in glaucoma

Functional microvascular volume as a proportion of tissue volume is reduced in the RNFL but not the ONH rim at the onset of experimental glaucoma

During progression of glaucomatous damage, the rate of functional microvascular tissue loss exceeds loss of non-vascular tissue within the retinal nerve fiber layer, but declines proportionally within the optic nerve head neuroretinal rim

Restoration of mitochondrial axonal transport by adaptor supplementation prevents neurodegeneration and rescues visual function in glaucoma

Autophagy Dysfunction Represses mTORC1 Signaling Resulting in Neurodegeneration of Retinal Ganglion Cells in Glaucoma

Insulin promotes RGC dendrite regeneration through ribosomal protein S6 kinase activation leading to restoration of neuronal function in glaucoma

Light-evoked RGC calcium dynamics are altered in glaucoma: live imaging evidence of abnormal calcium clearance

A novel femtomolar hemodynamic modulation strategy reveals major microvascular defects in glaucoma at single-pericyte scale

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