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Physiology and Pharmacology July 2019

Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

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Wennan Lu; Keith E. Campagno; Huen-Yee Tso; Aurora Cenaj; Alan M. Laties; Leif G. Carlsson; Claire H. Mitchell
TAGS: mice, photoreceptors, retinal degeneration, ticagrelor, antagonists, administration, oral
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3046-3053. doi: https://doi.org/10.1167/iovs.19-27241

ARVO Annual Meeting Abstract June 2017

Antagonism of P2Y12 Receptor by Ticagrelor Leads to Acidification of Lysosomes in Retinal Pigmented Epithelial (RPE) Cells from ABCA4 -/- Mice

Wennan Lu; Alan M Laties; Leif Carlsson; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2034. doi:

ARVO Annual Meeting Abstract September 2016

Increased inflammasome priming and microglial activation in a mouse model of chloroquine retinopathy

Wennan Lu; Nestor Mas Gomez; Alan M Laties; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2237. doi:

ARVO Annual Meeting Abstract June 2015

TLR3 stimulation leads to ATP release through lysosomal exocytosis from optic nerve head astrocytes and RPE cells

Claire H Mitchell; Nestor Mas Gomez; Jason C Lim; Wennan Lu; Jonathan Beckel; Alan M Laties

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2373. doi:

ARVO Annual Meeting Abstract June 2015

Chloroquine retinopathy as a modern model of macular degeneration

Wennan Lu; Nestor Gomez; Jason C Lim; Alan M Laties; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4218. doi:

ARVO Annual Meeting Abstract June 2015

Lysosomal stress impairs calcium signaling by TRPML in RPE cells

Nestor Mas Gomez; Wennan Lu; Jason C Lim; Alan M Laties; Kirill Kiselyov; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5437. doi:

Glaucoma May 2015

Rat, Mouse, and Primate Models of Chronic Glaucoma Show Sustained Elevation of Extracellular ATP and Altered Purinergic Signaling in the Posterior Eye

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Wennan Lu; HuiLing Hu; Jean Sévigny; B'Ann T. Gabelt; Paul L. Kaufman; Elaine C. Johnson; John C. Morrison; Gulab S. Zode; Val C. Sheffield; Xiulan Zhang; Alan M. Laties; Claire H. Mitchell
TAGS: eye, glaucoma, intraocular pressure, mice, primates, entpd1 gene, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2015; 56(5):3075-3083. doi: https://doi.org/10.1167/iovs.14-15891

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Sustained rise in extracellular ATP in retina of transgenic Tg-MYOC Y437H mice

Wennan Lu; Jean Sévigny; Gulab S Zode; Val Sheffield; Alan M Laties; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1345. doi:

ARVO Annual Meeting Abstract April 2014

Age-dependent increases in lysosomal pH, lysosomal gene expression and autofluorescence of mouse RPE cells; parallels with the ABCA4-/- mice suggest causal factors in age-dependent pathophysiology

Jason Lim; Wennan Lu; Alan M Laties; Claire H Mitchell

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2957. doi:

ARVO Annual Meeting Abstract April 2014

TLR3 stimulation leads to ATP release from both RPE cells and optic nerve head astrocytes; a common pathway to escalate the inflammatory response in ocular cells?

Claire H Mitchell; Jonathan M Beckel; Wennan Lu; Jason Lim; Alan M Laties

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6344. doi:

Glaucoma March 2013

Choroidal Thickness in Fellow Eyes of Patients with Acute Primary Angle-Closure Measured by Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

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Minwen Zhou; Wei Wang; Xiaoyan Ding; Wenbin Huang; Shida Chen; Alan M. Laties; Xiulan Zhang
TAGS: atrial premature complexes, diagnostic imaging, eye, optical coherence tomography, primary angle closure suspect, choroid
Invest. Ophthalmol. Vis. Sci.. 2013; 54(3):1971-1978. doi: https://doi.org/10.1167/iovs.12-11090

ARVO Annual Meeting Abstract March 2012

Autophagy and Cytokine Release from RPE Cells

Claire H. Mitchell; Sonia Guha; Jason C. Lim; Alan M. Laties

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3703. doi:

ARVO Annual Meeting Abstract March 2012

Multiple Autofluorescent Peaks In RPE Of Control And ABCA4-/- Mice: A Role For Perturbed Autophagy?

Ann C. O'Brien-Jenkins; Sonia Guha; Wennan Lu; Bardia Nabet; Gabriel Baltazar; Alan M. Laties; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4758. doi:

ARVO Annual Meeting Abstract March 2012

Stretch-activated IL-3 Release From Retinal Ganglion Cells Is Protective And Involves The P2X7 Receptor

Jason C. Lim; Wennan Lu; Jonathan M. Beckel; Margaret Buell; Jingsheng Xia; Edward J. Macarak; Alan M. Laties; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6594. doi:

ARVO Annual Meeting Abstract March 2012

Mechanosensitive Channels In Isolated Rat Retina Ganglion Cells: Response To Strain From Within Neurons

Jingsheng Xia; Jason C. Lim; Wennan Lu; Jonathan M. Beckel; Alan M. Laties; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6603. doi:

ARVO Annual Meeting Abstract April 2011

Acidic Nanoparticles Enhance Degradative Lysosomal Enzyme Activity In Compromised Rpe Cells

Gabriel Baltazar; Sonia Guha; Alan M. Laties; Puneet Tyagi; Uday B. Kompella; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3216. doi:

ARVO Annual Meeting Abstract April 2011

Release Of Il-6 And MCP-1 From Rpe Cells Follows Stimulation Of The P2X7 Receptor For ATP

Claire H. Mitchell; Sonia Guha; Gabriel Baltazar; Jason C. Lim; Thor Eysteinsson; Alan M. Laties

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1227. doi:

ARVO Annual Meeting Abstract April 2011

Optic Nerve Astrocytes Release ATP upon Mechanical Strain

Jonathan M. Beckel; Arthur J. Argall; Jason C. Lim; Mohammad Shahidullah; Edward J. Macarak; Alan M. Laties; Nicholas A. Delamere; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1819. doi:

ARVO Annual Meeting Abstract April 2011

Mechanosensitive Release Of Cytokines And Chemokines From Isolated Retinal Ganglion Cells

Jason C. Lim; Wennan Lu; Jonathan M. Beckel; Edward J. Macarak; Alan M. Laties; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5458. doi:

ARVO Annual Meeting Abstract April 2011

Activation of Calcium-activated Potassium Channel Following Stimulation of P2X7 Receptors in Retinal Ganglion Cells

Jingsheng Xia; Jason C. Lim; Wennan Lu; Jonathan M. Beckel; Alan M. Laties; Claire H. Mitchell

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5631. doi:

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Oral Delivery of the P2Y 12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4 −/− Mouse Model of Retinal Degeneration

Antagonism of P2Y12 Receptor by Ticagrelor Leads to Acidification of Lysosomes in Retinal Pigmented Epithelial (RPE) Cells from ABCA4 -/- Mice

Increased inflammasome priming and microglial activation in a mouse model of chloroquine retinopathy

TLR3 stimulation leads to ATP release through lysosomal exocytosis from optic nerve head astrocytes and RPE cells

Chloroquine retinopathy as a modern model of macular degeneration

Lysosomal stress impairs calcium signaling by TRPML in RPE cells

Rat, Mouse, and Primate Models of Chronic Glaucoma Show Sustained Elevation of Extracellular ATP and Altered Purinergic Signaling in the Posterior Eye

Sustained rise in extracellular ATP in retina of transgenic Tg-MYOC Y437H mice

Age-dependent increases in lysosomal pH, lysosomal gene expression and autofluorescence of mouse RPE cells; parallels with the ABCA4-/- mice suggest causal factors in age-dependent pathophysiology

TLR3 stimulation leads to ATP release from both RPE cells and optic nerve head astrocytes; a common pathway to escalate the inflammatory response in ocular cells?

Choroidal Thickness in Fellow Eyes of Patients with Acute Primary Angle-Closure Measured by Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

Autophagy and Cytokine Release from RPE Cells

Multiple Autofluorescent Peaks In RPE Of Control And ABCA4-/- Mice: A Role For Perturbed Autophagy?

Stretch-activated IL-3 Release From Retinal Ganglion Cells Is Protective And Involves The P2X7 Receptor

Mechanosensitive Channels In Isolated Rat Retina Ganglion Cells: Response To Strain From Within Neurons

Acidic Nanoparticles Enhance Degradative Lysosomal Enzyme Activity In Compromised Rpe Cells

Release Of Il-6 And MCP-1 From Rpe Cells Follows Stimulation Of The P2X7 Receptor For ATP

Optic Nerve Astrocytes Release ATP upon Mechanical Strain

Mechanosensitive Release Of Cytokines And Chemokines From Isolated Retinal Ganglion Cells

Activation of Calcium-activated Potassium Channel Following Stimulation of P2X7 Receptors in Retinal Ganglion Cells

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