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ARVO Annual Meeting Abstract June 2022

12/15-Lipoxygenase Contributes to Retinal Neuronal Dysfunction in Diabetic Retinopathy

Mohamed Moustafa; Andrew Ensley; Ahmed Ibrahim; Alan saul; Dao-Qi Zhang; Mohamed Al-Sayed Al-Shabrawey

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3596 – A0051.

Retinal Cell Biology March 2020

Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa

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Haiyan Xiao; Jing Wang; Alan Saul; Sylvia B. Smith
TAGS: ligands, mice, neuroprotective effect, pentazocine, retinal cone, retinitis pigmentosa, retina, electroretinography, antioxidants, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):5. https://doi.org/10.1167/iovs.61.3.5

Retinal Cell Biology October 2019

Activation of Sigma 1 Receptor Extends Survival of Cones and Improves Visual Acuity in a Murine Model of Retinitis Pigmentosa

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Jing Wang; Alan Saul; Sylvia B. Smith
TAGS: ligands, mice, retinal cone, visual acuity, retinitis pigmentosa, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4397-4407. https://doi.org/10.1167/iovs.19-27709

Includes: Supplemental Content

Retina November 2018

A Controlled Impact of Optic Nerve as a New Model of Traumatic Optic Neuropathy in Mouse

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Ahmed S. Ibrahim; Khaled Elmasry; Ming Wan; Samer Abdulmoneim; Amber Still; Farid Khan; Abraham Khalil; Alan Saul; Md Nasrul Hoda; Mohamed Al-Shabrawey
TAGS: eye, mice, optic nerve, optic nerve injuries, wounds and injuries, electroretinography, velocity
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5548-5557. https://doi.org/10.1167/iovs.18-24773

Includes: Multimedia, Supplemental Content

Retinal Cell Biology September 2017

Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa

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Jing Wang; Alan Saul; Xuezhi Cui; Penny Roon; Sylvia B. Smith
TAGS: mice, retina, photoreceptors, retinitis pigmentosa
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4545-4558. https://doi.org/10.1167/iovs.17-21947

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Spermine Oxidase: a novel mediator of diabetes-induced retinal neurodegeneration

S. Priya Narayanan; Alan Saul; Zhimin Xu; Prahalathan Pichavaram

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5198.

ARVO Annual Meeting Abstract September 2016

Helping retina to breathe by increasing fetal hemoglobin production in RPE: relevance to outer retinal preservation in hypoxic conditions characteristic of aging and diabetes

Pamela M Martin; Wanwisa Promsote; Folami Lamoke Powell; Alan Saul; Vadivel Ganapathy; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):242.

ARVO Annual Meeting Abstract September 2016

Neurovascular Injury after Retinal Ischemia Reperfusion Insult: Contrasting Roles of Arginase Enzyme Isoforms

Esraa Shosha; Zhimin Xu; Harumasa Yokota; Ji Xing; R. William Caldwell; Alan Saul; S.Priya Narayanan; Ruth B Caldwell

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):746.

ARVO Annual Meeting Abstract September 2016

Retinal Iron Overload during Diabetic Retinopathy Accelerates Ganglion Cell Death

Jaya P Gnana-Prakasam; Kapil Chaudhary; Wanwisa Promsote; Sylvia B Smith; Vadivel Ganapathy; Pamela M Martin; Alan Saul

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):751.

ARVO Annual Meeting Abstract September 2016

Absence of Sigma 1 Receptor (σ1R) accelerates photoreceptor cell (PRC) loss in Pde6b rd10 /J ( rd10) mice.

Sylvia B Smith; Jing Wang; Alan Saul; Xuezhi Cui; Penny Roon

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2732.

ARVO Annual Meeting Abstract September 2016

Loss of GPR109A results in RPE dysfunction, neurodegeneration and increased oxidative stress with age: Potential relevance to AMD

Folami Lamoke; Pachiappan Arjunan; Shaquanna Young; Sylvia B Smith; Alan Saul; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

ARVO Annual Meeting Abstract June 2015

Supplementing Dietary DHA Attenuates Traumatic Optic Neuropathy by Manipulating 12/15-Lipoxygenase Activity

Farid M Khan; Ahmed S Ibrahim; amber still; Alan Saul; Nasrul Hoda; Mohamed Al-Sayed Al-Shabrawey; Al-Shabrawey Laboratory at Georgia Regents University

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):6028.

ARVO Annual Meeting Abstract June 2015

Mild hyperhomocysteinemia (Hhcy) leads to modest retinal ganglion cell (RGC) dysfunction and focal vascular leakiness in rd8-free methylenetetrahydrofolate reductase ( Mthfr ) deficient mice.

Shanu Markand; Alan Saul; Rima Rozen; Arul Shanmugam; Vadivel Ganapathy; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4262.

ARVO Annual Meeting Abstract June 2015

Neuroprotective effects of growth hormone releasing hormone (GHRH) in traumatic optic neuropathy

Manuela Bartoli; Amany M Tawfik; Alan Saul; Sagar Y Patel; David Gay; Gregory Ing Liou; Sylvia B Smith; Julian J Nussbaum; Folami Lamoke

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4363.

ARVO Annual Meeting Abstract June 2015

(+)-Pentazocine ((+)-PTZ), a high affinity sigma 1 receptor (σ 1 R) ligand preserves cone function in the Pde6 rd10 (Rd10) mouse model of retinitis pigmentosa

Jing Wang; Alan Saul; Vadivel Ganapathy; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5475.

Retinal Cell Biology April 2015

Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia

PDF

Shanu Markand; Alan Saul; Penny Roon; Puttur Prasad; Pamela Martin; Rima Rozen; Vadivel Ganapathy; Sylvia B. Smith
TAGS: methylenetetrahydrofolate reductase (nadph2), mice, retina, vascular diseases, hyperhomocysteinemia
Invest. Ophthalmol. Vis. Sci.. 2015; 56(4):2684-2695. https://doi.org/10.1167/iovs.14-16190

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Protective effects of Growth Hormone Releasing Hormone (GHRH) agonism in the diabetic retina

Sean Shaw; Sagar Yatin Patel; Folami Lamoke; Jianghe Yuan; Alan Saul; Gregory Ing Liou; Norman Block; Andrew Shally; Manuela Bartoli

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2179.

ARVO Annual Meeting Abstract April 2014

Comprehensive characterization of retinal phenotypic changes in methylene tetrahydrofolate reductase (MTHFR) deficient mice: a model of hyperhomocysteinemia (HHcy)

Shanu Markand; Arul Shanmugam; Amany Tawfik; Penny Roon; Alan Saul; Rima Rozen; Vadivel Ganapathy; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):353.

ARVO Annual Meeting Abstract March 2012

Increased Susceptibility to Retinal Stress in Mice Lacking Sigma Receptor 1 (R1)

Yonju Ha; Alan Saul; Cory Williams; Eric Zorrilla; Vadivel Ganapathy; Sylvia B. Smith

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6417.

Retinal Cell Biology September 2011

Late-Onset Inner Retinal Dysfunction in Mice Lacking Sigma Receptor 1 (σR1)

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Yonju Ha; Alan Saul; Amany Tawfik; Cory Williams; Kathryn Bollinger; Robert Smith; Masanori Tachikawa; Eric Zorrilla; Vadivel Ganapathy; Sylvia B. Smith
TAGS: longitudinal relaxation rate, mice, pathophysiology, receptors, sigma, eye, retina
Invest. Ophthalmol. Vis. Sci.. 2011; 52(10):7749-7760. https://doi.org/10.1167/iovs.11-8169

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12/15-Lipoxygenase Contributes to Retinal Neuronal Dysfunction in Diabetic Retinopathy

Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa

Activation of Sigma 1 Receptor Extends Survival of Cones and Improves Visual Acuity in a Murine Model of Retinitis Pigmentosa

A Controlled Impact of Optic Nerve as a New Model of Traumatic Optic Neuropathy in Mouse

Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa

Spermine Oxidase: a novel mediator of diabetes-induced retinal neurodegeneration

Helping retina to breathe by increasing fetal hemoglobin production in RPE: relevance to outer retinal preservation in hypoxic conditions characteristic of aging and diabetes

Neurovascular Injury after Retinal Ischemia Reperfusion Insult: Contrasting Roles of Arginase Enzyme Isoforms

Retinal Iron Overload during Diabetic Retinopathy Accelerates Ganglion Cell Death

Absence of Sigma 1 Receptor (σ1R) accelerates photoreceptor cell (PRC) loss in Pde6b rd10 /J ( rd10) mice.

Loss of GPR109A results in RPE dysfunction, neurodegeneration and increased oxidative stress with age: Potential relevance to AMD

Supplementing Dietary DHA Attenuates Traumatic Optic Neuropathy by Manipulating 12/15-Lipoxygenase Activity

Mild hyperhomocysteinemia (Hhcy) leads to modest retinal ganglion cell (RGC) dysfunction and focal vascular leakiness in rd8-free methylenetetrahydrofolate reductase ( Mthfr ) deficient mice.

Neuroprotective effects of growth hormone releasing hormone (GHRH) in traumatic optic neuropathy

(+)-Pentazocine ((+)-PTZ), a high affinity sigma 1 receptor (σ 1 R) ligand preserves cone function in the Pde6 rd10 (Rd10) mouse model of retinitis pigmentosa

Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia

Protective effects of Growth Hormone Releasing Hormone (GHRH) agonism in the diabetic retina

Comprehensive characterization of retinal phenotypic changes in methylene tetrahydrofolate reductase (MTHFR) deficient mice: a model of hyperhomocysteinemia (HHcy)

Increased Susceptibility to Retinal Stress in Mice Lacking Sigma Receptor 1 (R1)

Late-Onset Inner Retinal Dysfunction in Mice Lacking Sigma Receptor 1 (σR1)

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