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Physiology and Pharmacology August 2019

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

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Caitriona O'Leary; Mary K. McGahon; Sadaf Ashraf; Jennifer McNaughten; Thomas Friedel; Patrizia Cincolà; Peter Barabas; Jose A. Fernandez; Alan W. Stitt; J. Graham McGeown; Tim M. Curtis
TAGS: angiogenesis, trpv1 receptor
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3297-3309. doi: 10.1167/iovs.18-26344

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract July 2019

Anatomical response to anti-vascular endothelial growth factor (anti-VEGF) in patients with diabetic macular edema (DME) and its potential “in vitro” prediction by using Induced Pluripotent Stem Cell (IPSC)-derived endothelial cells (ECs).

Noemi Lois; Andriana Margariti; Marta Vila-Gonzalez; Stephen Stewart; Gianni Virgili; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3864. doi:

ARVO Annual Meeting Abstract July 2019

Pre-treatment of Endothelial Colony Forming Cells (ECFCs) with a novel anti-oxidant enhances their vasoregenerative potential.

Stuart McKeown; Paul Canning; Caroline Barelle; Fiona Cunningham; Donald McPhail; Andrew J.R Porter; Reinhold J. Medina; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1663. doi:

ARVO Annual Meeting Abstract July 2019

Placental growth factor (PlGF) induced signalling regulates barrier properties of the retinal pigment epithelium (RPE)

Fiona Cunningham; Paul Canning; Tine Van Bergen; Jean Feyen; Imre Lengyel; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1932. doi:

ARVO Annual Meeting Abstract July 2019

Metabolic plasticity in retinal microvascular endothelial cells exposed to diabetes-related conditions in vitro

David Hughes; Pietro Maria Bertelli; Stuart McKeown; Paul Canning; Elisa Peixoto; Tim M Curtis; Reinhold J. Medina; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2705. doi:

ARVO Annual Meeting Abstract July 2019

ARA290 (cibinetide) treatment confers neuroprotective effects in diabetic retinopathy, through modulation of inflammatory mediators.

Paul Canning; Olivia O'Leary; Lynsey-Dawn Allen; Michael Brines; Anthony Cerami; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2720. doi:

ARVO Annual Meeting Abstract July 2019

Systemic Delivery Of Endothelial Colony Forming Cells Enables Vascular Integration Into Diabetic Mouse retinas, But Not Diabetic Mouse Retinas Treated With AAV2.COMP-Ang1

Lara Carroll; Xiaohui Zhang; Yufeng Huang; Yuanyuan Wu; Alan W Stitt; Tim M Curtis; Reinhold J. Medina; Balamurali K Ambati

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2724. doi:

Retina June 2019

Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina

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Lara S. Carroll; Hironori Uehara; Daniel Fang; Susie Choi; Xiaohui Zhang; Malkit Singh; Zoya Sandhu; Philip M. Cummins; Tim M. Curtis; Alan W. Stitt; Bonnie J. Archer; Balamurali K. Ambati
TAGS: angiotensin i, blood capillaries, diabetes mellitus, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2494-2502. doi: 10.1167/iovs.18-26182

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Wedelolactone protects DNA-induced photoreceptor death

Kevin Harkin; Sofia Pavlou; Alan W Stitt; Heping Xu; Mei Chen

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1002. doi:

ARVO Annual Meeting Abstract July 2018

Increased diabetic retinal neuronal degeneration in IL-33 -/- mice is related to reduced Müller cell-derived neurotrophic factors

Josy Augustine; Sofia Pavlou; Alan W Stitt; Heping Xu; Mei Chen

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1211. doi:

ARVO Annual Meeting Abstract July 2018

Endothelial colony forming cells modulate angiogenesis by directly integrating with the choroidal vasculature

Stuart McKeown; Paul Canning; Stacy McNutt; Reinhold Medina; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5490. doi:

ARVO Annual Meeting Abstract July 2018

Endothelial Cellular Senescence in the Pathogenesis of Diabetic Retinopathy

Pietro Maria Bertelli; Elisa Peixoto; Christina O'Neill; Jasenka Guduric-Fuchs; Lynsey-Dawn Allen; Alan W Stitt; Reinhold Medina

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3554. doi:

ARVO Annual Meeting Abstract July 2018

Interleukin-33 deficiency resulted in severe neuroretinal degeneration in retinal detachment

Mei Chen; Josy Augustine; Sofia Pavlou; Imran Ali; Sarah Doyle; Alan W Stitt; Matthew Campbell; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3942. doi:

Review December 2017

Animal Models of Retinal Vein Occlusion

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Meiaad Khayat; Noemi Lois; Michael Williams; Alan W. Stitt
TAGS: lasers, light coagulation, animal model, primates, central vein of the retina, retinal vein occlusion, eye, histopathology tests, intravitreal injections, macular edema
Invest. Ophthalmol. Vis. Sci.. 2017; 58(14):6175-6192. doi: 10.1167/iovs.17-22788

ARVO Annual Meeting Abstract September 2016

A unique population of stromal stem cells (SSCs) protect against neurovascular dysfunction during diabetic retinopathy

Vickie Hoi Ying Wong; Lynsey-Dawn Allen; Stephen J Elliman; Lisa O'Flynn; Paul Loftus; Cynthia Coleman; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6075. doi:

ARVO Annual Meeting Abstract September 2016

CD362+ stromal stem cells(SSCs) stabilize vascular networks through differentiation into pericyte-like cells

Juan Liang; Vickie Hoi Ying Wong; Lynsey-Dawn Allen; Stephen J Elliman; Paul Loftus; Lisa O'Flynn; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6076. doi:

ARVO Annual Meeting Abstract September 2016

Evidence of Increased Neuronal Glycogen Storage in Short-term Diabetes

Tom A Gardiner; Paul Canning; Nuala Tipping; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2718. doi:

ARVO Annual Meeting Abstract September 2016

Inflammasome activation in the photoreceptor cells

Ronan Cunning; Sofia Pavlou; Alan W Stitt; Heping Xu; Mei Chen

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2730. doi:

ARVO Annual Meeting Abstract September 2016

Pro-Tissue Repair capacity of circulating angiogenic cells (CACs) is impaired when exposed to High Glucose

Jasenka Guduric-Fuchs; Sarah Chambers; Christina O Neill; Reinhold Medina; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4524. doi:

ARVO Annual Meeting Abstract September 2016

Deletion of interleukin-33 (IL33) results in persistent Müller cell activation during retinal detachment

Sofia Pavlou; Josy Augustine; Sarah Doyle; Alan W Stitt; Matthew Campbell; Heping Xu; Mei Chen

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5383. doi:

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Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

Anatomical response to anti-vascular endothelial growth factor (anti-VEGF) in patients with diabetic macular edema (DME) and its potential “in vitro” prediction by using Induced Pluripotent Stem Cell (IPSC)-derived endothelial cells (ECs).

Pre-treatment of Endothelial Colony Forming Cells (ECFCs) with a novel anti-oxidant enhances their vasoregenerative potential.

Placental growth factor (PlGF) induced signalling regulates barrier properties of the retinal pigment epithelium (RPE)

Metabolic plasticity in retinal microvascular endothelial cells exposed to diabetes-related conditions in vitro

ARA290 (cibinetide) treatment confers neuroprotective effects in diabetic retinopathy, through modulation of inflammatory mediators.

Systemic Delivery Of Endothelial Colony Forming Cells Enables Vascular Integration Into Diabetic Mouse retinas, But Not Diabetic Mouse Retinas Treated With AAV2.COMP-Ang1

Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina

Wedelolactone protects DNA-induced photoreceptor death

Increased diabetic retinal neuronal degeneration in IL-33 -/- mice is related to reduced Müller cell-derived neurotrophic factors

Endothelial colony forming cells modulate angiogenesis by directly integrating with the choroidal vasculature

Endothelial Cellular Senescence in the Pathogenesis of Diabetic Retinopathy

Interleukin-33 deficiency resulted in severe neuroretinal degeneration in retinal detachment

Animal Models of Retinal Vein Occlusion

A unique population of stromal stem cells (SSCs) protect against neurovascular dysfunction during diabetic retinopathy

CD362+ stromal stem cells(SSCs) stabilize vascular networks through differentiation into pericyte-like cells

Evidence of Increased Neuronal Glycogen Storage in Short-term Diabetes

Inflammasome activation in the photoreceptor cells

Pro-Tissue Repair capacity of circulating angiogenic cells (CACs) is impaired when exposed to High Glucose

Deletion of interleukin-33 (IL33) results in persistent Müller cell activation during retinal detachment

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