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ARVO Annual Meeting Abstract June 2022

THR-687, a potent pan-RGD integrin antagonist, protects against retinal vascular permeability, inflammation and reactive gliosis in the diabetic rat

Tine Van Bergen; Astrid De Vriese; Bart Jonckx; Kelly Vanhulst; Marc Vanhove; Michaël Porcu; Elke Vermassen; Philippe Barbeaux; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2306. doi:

ARVO Annual Meeting Abstract June 2022

2-Hydrazino-4,6-dimethylpyrimidine (2-HDP) as a novel therapeutic for the neurovascular pathology of diabetic retinopathy

Josy Augustine; Evan P Troendle; Thomas Friedel; Eimear M Byrne; Paul Canning; Peter Barabas; Martin B Ulmschneider; Alan W Stitt; Tim M Curtis

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2305. doi:

ARVO Annual Meeting Abstract June 2022

Deletion of Angiotensin II type 2 receptor (AT2) exacerbates retinal neovascularization and hemorrhage in oxygen-induced retinopathy (OIR)

Kevin Harkin; Pietro Bertelli; Hazal Yilmaz; Paul Canning; Ana Rodriguez; Thomas Walther; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2677. doi:

ARVO Annual Meeting Abstract June 2022

"Mapping in time" the daily rhythmic transcriptome in the diabetic retina

Eleni Beli; Ryan P Silk; Hanagh R Winter; Vijay Tiwari; David Simpson; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):281 – F0326. doi:

ARVO Annual Meeting Abstract June 2022

Characterising retinal neurovascular dysfunction in a mouse model of Alzheimer’s disease combined with Type 2 diabetes

Karis Little; María Llorián-Salvador; Ángel del Marco; Monica Garcia-Alloza; Rafael Simó; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):271 – F0316. doi:

ARVO Annual Meeting Abstract June 2022

Regulatory T cells limit age-associated retinal degeneration

Maria Llorian-Salvador; Alerie Guzman de la Fuente; Alan W Stitt; Denise Fitzgerald

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):963 – A0432. doi:

ARVO Annual Meeting Abstract June 2022

Circadian rhythms in diabetic retinal endothelial cells

Hanagh Winter; Andriana Margariti; Alan W Stitt; Eleni Beli

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):790 – F0349. doi:

Retina October 2021

Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model

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Tine Van Bergen; Tjing-Tjing Hu; Karis Little; Lies De Groef; Lieve Moons; Alan W. Stitt; Elke Vermassen; Jean H. M. Feyen
TAGS: diabetes mellitus, plasma kallikrein, eye, peptides
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):18. doi: https://doi.org/10.1167/iovs.62.13.18

Physiology and Pharmacology August 2019

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

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Caitriona O'Leary; Mary K. McGahon; Sadaf Ashraf; Jennifer McNaughten; Thomas Friedel; Patrizia Cincolà; Peter Barabas; Jose A. Fernandez; Alan W. Stitt; J. Graham McGeown; Tim M. Curtis
TAGS: angiogenesis, trpv1 receptor
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3297-3309. doi: https://doi.org/10.1167/iovs.18-26344

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract July 2019

Pre-treatment of Endothelial Colony Forming Cells (ECFCs) with a novel anti-oxidant enhances their vasoregenerative potential.

Stuart McKeown; Paul Canning; Caroline Barelle; Fiona Cunningham; Donald McPhail; Andrew J.R Porter; Reinhold J. Medina; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1663. doi:

ARVO Annual Meeting Abstract July 2019

Placental growth factor (PlGF) induced signalling regulates barrier properties of the retinal pigment epithelium (RPE)

Fiona Cunningham; Paul Canning; Tine Van Bergen; Jean Feyen; Imre Lengyel; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1932. doi:

ARVO Annual Meeting Abstract July 2019

Metabolic plasticity in retinal microvascular endothelial cells exposed to diabetes-related conditions in vitro

David Hughes; Pietro Maria Bertelli; Stuart McKeown; Paul Canning; Elisa Peixoto; Tim M Curtis; Reinhold J. Medina; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2705. doi:

ARVO Annual Meeting Abstract July 2019

ARA290 (cibinetide) treatment confers neuroprotective effects in diabetic retinopathy, through modulation of inflammatory mediators.

Paul Canning; Olivia O'Leary; Lynsey-Dawn Allen; Michael Brines; Anthony Cerami; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2720. doi:

ARVO Annual Meeting Abstract July 2019

Systemic Delivery Of Endothelial Colony Forming Cells Enables Vascular Integration Into Diabetic Mouse retinas, But Not Diabetic Mouse Retinas Treated With AAV2.COMP-Ang1

Lara Carroll; Xiaohui Zhang; Yufeng Huang; Yuanyuan Wu; Alan W Stitt; Tim M Curtis; Reinhold J. Medina; Balamurali K Ambati

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2724. doi:

ARVO Annual Meeting Abstract July 2019

Anatomical response to anti-vascular endothelial growth factor (anti-VEGF) in patients with diabetic macular edema (DME) and its potential “in vitro” prediction by using Induced Pluripotent Stem Cell (IPSC)-derived endothelial cells (ECs).

Noemi Lois; Andriana Margariti; Marta Vila-Gonzalez; Stephen Stewart; Gianni Virgili; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3864. doi:

Retina June 2019

Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina

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Lara S. Carroll; Hironori Uehara; Daniel Fang; Susie Choi; Xiaohui Zhang; Malkit Singh; Zoya Sandhu; Philip M. Cummins; Tim M. Curtis; Alan W. Stitt; Bonnie J. Archer; Balamurali K. Ambati
TAGS: angiotensin i, blood capillaries, diabetes mellitus, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2494-2502. doi: https://doi.org/10.1167/iovs.18-26182

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Endothelial Cellular Senescence in the Pathogenesis of Diabetic Retinopathy

Pietro Maria Bertelli; Elisa Peixoto; Christina O'Neill; Jasenka Guduric-Fuchs; Lynsey-Dawn Allen; Alan W Stitt; Reinhold Medina

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3554. doi:

ARVO Annual Meeting Abstract July 2018

Interleukin-33 deficiency resulted in severe neuroretinal degeneration in retinal detachment

Mei Chen; Josy Augustine; Sofia Pavlou; Imran Ali; Sarah Doyle; Alan W Stitt; Matthew Campbell; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3942. doi:

ARVO Annual Meeting Abstract July 2018

Endothelial colony forming cells modulate angiogenesis by directly integrating with the choroidal vasculature

Stuart McKeown; Paul Canning; Stacy McNutt; Reinhold Medina; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5490. doi:

ARVO Annual Meeting Abstract July 2018

Wedelolactone protects DNA-induced photoreceptor death

Kevin Harkin; Sofia Pavlou; Alan W Stitt; Heping Xu; Mei Chen

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1002. doi:

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THR-687, a potent pan-RGD integrin antagonist, protects against retinal vascular permeability, inflammation and reactive gliosis in the diabetic rat

2-Hydrazino-4,6-dimethylpyrimidine (2-HDP) as a novel therapeutic for the neurovascular pathology of diabetic retinopathy

Deletion of Angiotensin II type 2 receptor (AT2) exacerbates retinal neovascularization and hemorrhage in oxygen-induced retinopathy (OIR)

"Mapping in time" the daily rhythmic transcriptome in the diabetic retina

Characterising retinal neurovascular dysfunction in a mouse model of Alzheimer’s disease combined with Type 2 diabetes

Regulatory T cells limit age-associated retinal degeneration

Circadian rhythms in diabetic retinal endothelial cells

Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

Pre-treatment of Endothelial Colony Forming Cells (ECFCs) with a novel anti-oxidant enhances their vasoregenerative potential.

Placental growth factor (PlGF) induced signalling regulates barrier properties of the retinal pigment epithelium (RPE)

Metabolic plasticity in retinal microvascular endothelial cells exposed to diabetes-related conditions in vitro

ARA290 (cibinetide) treatment confers neuroprotective effects in diabetic retinopathy, through modulation of inflammatory mediators.

Systemic Delivery Of Endothelial Colony Forming Cells Enables Vascular Integration Into Diabetic Mouse retinas, But Not Diabetic Mouse Retinas Treated With AAV2.COMP-Ang1

Anatomical response to anti-vascular endothelial growth factor (anti-VEGF) in patients with diabetic macular edema (DME) and its potential “in vitro” prediction by using Induced Pluripotent Stem Cell (IPSC)-derived endothelial cells (ECs).

Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina

Endothelial Cellular Senescence in the Pathogenesis of Diabetic Retinopathy

Interleukin-33 deficiency resulted in severe neuroretinal degeneration in retinal detachment

Endothelial colony forming cells modulate angiogenesis by directly integrating with the choroidal vasculature

Wedelolactone protects DNA-induced photoreceptor death

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