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Retina January 2023

Optimization and Validation of a Virtual Reality Orientation and Mobility Test for Inherited Retinal Degenerations

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Jean Bennett; Elena M. Aleman; Katherine H. Maguire; Jennifer Nadelmann; Mariejel L. Weber; William M. Maguire; Ayodele Maja; Erin C. O'Neil; Albert M. Maguire; Alexander J. Miller; Tomas S. Aleman
TAGS: luminance, mobility, mobility testing, retinal degeneration, virtual reality, vision, visual fields, questionnaires, eye
Trans. Vis. Sci. Tech.. 2023; 12(1):28. doi: https://doi.org/10.1167/tvst.12.1.28

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2022

A novel virtual reality orientation and mobility test to assess functional vision in patients with inherited retinal dystrophies

Jean Bennett; Elena M Aleman; Katherine Maguire; Alexander J Miller; Mariejel Weber; Ayodele Kobina Maja; Albert M Maguire; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4496 – F0283. doi:

ARVO Annual Meeting Abstract June 2022

Preparation for a Gene Therapy Trial for LCA5 -Associated Retinal Degenerations: Treatment Potential in Patients and Dose-ranging Studies in Non-human Primates

Paris Margaritis; Jean Bennett; Steven Chomistek; Vidyullatha Vasireddy; Ivan Shpylchak; Zhangyong Wei; Angela Luo; Junwei Sun; Shangzhen Zhou; Jennifer Pham; Albert M Maguire; Katherine E. Uyhazi; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4141 – F0378. doi:

ARVO Annual Meeting Abstract June 2022

Preparation for a Gene Augmentation Trial for RDH12 -Associated Retinal Degenerations

Tomas S Aleman; Brent A Bell; Steven Chomistek; Junwei Sun; Mariejel Weber; Jay V Pendyala; Albert M Maguire; Jennifer Pham; Ivan Shpylchak; Shangzhen Zhou; Angela Luo; Paris Margaritis; Zhangyong Wei; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4512 – F0299. doi:

ARVO Annual Meeting Abstract June 2022

Central Structural and Functional Abnormalities in Choroideremia: Longitudinal and Cross-sectional Observations from a Large Cohort of Patients

Erin O'Neil; Katherine E. Uyhazi; Kurt Scavelli; Keli O'Connor; Elizabeth Shagena; Yu You Jiang; Albert M Maguire; Jessica Ijams Wolfing Morgan; Jean Bennett; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4529 – F0316. doi:

Articles May 2022

Restoration of Vision and Retinal Responses After Adeno-Associated Virus–Mediated Optogenetic Therapy in Blind Dogs

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Sergei Nikonov; Puya Aravand; Arkady Lyubarsky; Roman Nikonov; Angela J. Luo; Zhangyong Wei; Albert M. Maguire; Nicholas T. Phelps; Ivan Shpylchak; Keirnan Willett; Tomas S. Aleman; Rachel M. Huckfeldt; Pavitra S. Ramachandran; Jean Bennett
TAGS: adeno-associated virus, dog, domestic, gene therapy, optogenetics, retina, retinal cone, vision, mice, animal model
Trans. Vis. Sci. Tech.. 2022; 11(5):24. doi: https://doi.org/10.1167/tvst.11.5.24

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Cone mosaic integrity in choroideremia following gene augmentation via subretinal injection of AAV2- hCHM

Jessica Ijams Wolfing Morgan; Yu You Jiang; Leona W Serrano; Denise J Pearson; Jean Bennett; Albert M Maguire; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):47. doi:

ARVO Annual Meeting Abstract June 2021

Five-Year Post-Injection Results of the Phase 3 Trial of Voretigene Neparvovec-rzyl in Biallelic RPE65 Mutation-Associated Inherited Retinal Disease

Jean Bennett; Stephen R Russell; Katherine A High; Arlene V Drack; Zi-Fan Yu; Daniel C Chung; Kathy Reape; Albert M Maguire

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3540. doi:

ARVO Imaging in the Eye Conference Abstract July 2020

Downstream effects of retinal gene therapy on the volume of the lateral geniculate nucleus (LGN): A functional and structural assessment

Mikhail Lipin; Philip Cook; Theresa Mowad; Jean Bennett; Albert Maguire; Manzar Ashtari

Invest. Ophthalmol. Vis. Sci.. 2020; 61(9):PB0042. doi:

ARVO Annual Meeting Abstract June 2020

Short-term assessment of subfoveal injection of AAV2- hCHM gene augmentation in Choroideremia using adaptive optics ophthalmoscopy

Jessica Ijams Wolfing Morgan; Yu You Jiang; Leona Serrano; Denise J. Pearson; Jean Bennett; Albert Maguire; Tomas Aleman

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1130. doi:

ARVO Annual Meeting Abstract June 2020

Natural History of Rod and Cone Photoreceptor Dysfunction in Choroideremia

Kurt Scavelli; Erin O'Neil; Leona Serrano; Denise J. Pearson; Jessica Ijams Wolfing Morgan; Albert Maguire; Jean Bennett; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3027. doi:

ARVO Annual Meeting Abstract July 2019

Cone Outer Segment Reflectance Entropy in Choroideremia

Andrew M. Huang; Robert F Cooper; Grace Vergilio; Jean Bennett; Albert M. Maguire; Tomas S Aleman; Jessica Ijams Wolfing Morgan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1030. doi:

ARVO Annual Meeting Abstract July 2019

Subfoveal gene augmentation therapy for choroideremia: One-year results from a Phase I/II trial of AAV2-hCHM

Rachel M Huckfeldt; Tomas S Aleman; Tu Doan; Xiao-Hong Wen; Carol Weigel-DiFranco; Daniel C Chung; Emily Liu; Eric A Pierce; Jean Bennett; Albert M. Maguire; Dean Eliott; Jason Comander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6401. doi:

ARVO Annual Meeting Abstract July 2019

Automated cone identification in adaptive optics retinal images of Choroideremia using a convolutional neural network

Jessica Ijams Wolfing Morgan; Min Chen; Grace Vergilio; Andrew M. Huang; Jean Bennett; Albert M. Maguire; Tomas S Aleman; Robert F Cooper

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1431. doi:

ARVO Annual Meeting Abstract July 2019

AAV2- hCHM Subretinal Delivery to the Macula in Choroideremia: 2 year Results of an Ongoing Phase I/II Gene Therapy Trial

Tomas S Aleman; Rachel M Huckfeldt; Leona Serrano; Grace Vergilio; Denise J Pearson; Katherine E. Uyhazi; Sarah McCague; Kathleen Marshall; Daniel C Chung; Emily Liu; Eric A Pierce; Jessica Ijams Wolfing Morgan; Jean Bennett; Dean Eliott; Jason Comander; Albert M. Maguire

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5173. doi:

ARVO Annual Meeting Abstract July 2019

Structural and Functional Abnormalities in Leber Congenital Amaurosis Caused by Mutations in RDH12: A Short-Term Longitudinal Study

Katherine E. Uyhazi; Leona Serrano; Grace Vergilio; Denise J Pearson; Albert M. Maguire; Jean Bennett; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4509. doi:

ARVO Annual Meeting Abstract July 2019

Visual Function Questionnaire Responses in the Voretigene Neparvovec Phase 3 Trial

Stephen R Russell; Albert M. Maguire; Jean Bennett; Paulo Falabella; Elliott H Sohn; Vinit B Mahajan; Daniel C Chung; Kathleen Z Reape; Katherine A High

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4968. doi:

Retina October 2018

RDH12 Mutations Cause a Severe Retinal Degeneration With Relatively Spared Rod Function

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Tomas S. Aleman; Katherine E. Uyhazi; Leona W. Serrano; Vidyullatha Vasireddy; Scott J. Bowman; Michael J. Ammar; Denise J. Pearson; Albert M. Maguire; Jean Bennett
TAGS: mutation, retina, retinal degeneration, rod photoreceptors, spectral domain-optical coherence tomography, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):5225-5236. doi: https://doi.org/10.1167/iovs.18-24708

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Cellular-scale assessment of visual function in Choroideremia

Jessica Ijams Wolfing Morgan; William Scott Tuten; Robert F Cooper; Grace K. Han; Gloria Young; Jean Bennett; Albert M Maguire; Tomas S Aleman; David H Brainard

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1151. doi:

ARVO Annual Meeting Abstract July 2018

Safety of the Subretinal Delivery of RGX-314 AAV8-anti-VEGF Fab Gene Therapy in NHP: Retinal Structure Over One Year

Michael J. Ammar; Elaine J Zhou; Jessica Ijams Wolfing Morgan; Katherine E Uyhazi; Arkady Lyubarsky; Erik Wielechowski; Gui-Shuang Ying; Erin Bote; Leah Makaron; Stephen Yoo; James Wilson; Jean Bennett; Albert M Maguire; Anna Tretiakova; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1422. doi:

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Optimization and Validation of a Virtual Reality Orientation and Mobility Test for Inherited Retinal Degenerations

A novel virtual reality orientation and mobility test to assess functional vision in patients with inherited retinal dystrophies

Preparation for a Gene Therapy Trial for LCA5 -Associated Retinal Degenerations: Treatment Potential in Patients and Dose-ranging Studies in Non-human Primates

Preparation for a Gene Augmentation Trial for RDH12 -Associated Retinal Degenerations

Central Structural and Functional Abnormalities in Choroideremia: Longitudinal and Cross-sectional Observations from a Large Cohort of Patients

Restoration of Vision and Retinal Responses After Adeno-Associated Virus–Mediated Optogenetic Therapy in Blind Dogs

Cone mosaic integrity in choroideremia following gene augmentation via subretinal injection of AAV2- hCHM

Five-Year Post-Injection Results of the Phase 3 Trial of Voretigene Neparvovec-rzyl in Biallelic RPE65 Mutation-Associated Inherited Retinal Disease

Downstream effects of retinal gene therapy on the volume of the lateral geniculate nucleus (LGN): A functional and structural assessment

Short-term assessment of subfoveal injection of AAV2- hCHM gene augmentation in Choroideremia using adaptive optics ophthalmoscopy

Natural History of Rod and Cone Photoreceptor Dysfunction in Choroideremia

Cone Outer Segment Reflectance Entropy in Choroideremia

Subfoveal gene augmentation therapy for choroideremia: One-year results from a Phase I/II trial of AAV2-hCHM

Automated cone identification in adaptive optics retinal images of Choroideremia using a convolutional neural network

AAV2- hCHM Subretinal Delivery to the Macula in Choroideremia: 2 year Results of an Ongoing Phase I/II Gene Therapy Trial

Structural and Functional Abnormalities in Leber Congenital Amaurosis Caused by Mutations in RDH12: A Short-Term Longitudinal Study

Visual Function Questionnaire Responses in the Voretigene Neparvovec Phase 3 Trial

RDH12 Mutations Cause a Severe Retinal Degeneration With Relatively Spared Rod Function

Cellular-scale assessment of visual function in Choroideremia

Safety of the Subretinal Delivery of RGX-314 AAV8-anti-VEGF Fab Gene Therapy in NHP: Retinal Structure Over One Year

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