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Genetics September 2019

MicroRNA-Related Genetic Variants Are Associated With Diabetic Retinopathy in Type 1 Diabetes Mellitus

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Ebony Liu; Georgia Kaidonis; Bennet J. McComish; Mark C. Gillies; Sotoodeh Abhary; Rohan W. Essex; John H. Chang; Bishwanath Pal; Mark Daniell; Stewart Lake; Nikolai Petrovsky; Alex W. Hewitt; Alicia Jenkins; Ecosse L. Lamoureux; Jonathan M. Gleadle; Jamie E. Craig; Kathryn P. Burdon
TAGS: diabetes mellitus, type 1, diabetic retinopathy, genes, genetics, micrornas, single nucleotide polymorphism
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3937-3942. doi: https://doi.org/10.1167/iovs.18-25570

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

A glaucoma polygenic risk score strongly associated with disease prediction and treatment intensity.

Jamie E Craig; Ayub Qassim; Xikun Han; Mark Hassall; Robert James Casson; Stuart L Graham; David A Mackey; Colin Willoughby; Kathryn P Burdon; John Landers; Emmanuelle Souzeau; Janey L Wiggs; Alex W Hewitt; Stuart MacGregor

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1619. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2019

Associations between optic disc measures and obstructive sleep apnoea in young adults

Samantha SY Lee; Nigel McArdle; Paul Sanfilippo; Seyhan Yazar; Peter Eastwood; Alex W Hewitt; David A Mackey

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1957. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2019

The correlation between Glaucoma polygenic risk score and IOP measured by Icare® HOME tonometry within and outside of office hours.

Mona S Awadalla; Mark Hassall; Ayub Qassim; thi thi nguyen; Xikun Han; Stuart MacGregor; John Landers; Jamie E Craig; David A Mackey; Alex W Hewitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2408. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2019

MicroRNA-143 plays a protective role in ischemia-induced retinal neovascularization

Guei-Sheung Liu; Jiang-Hui Wang; Jinying Chen; Leilei Tu; Vikrant Singh; Moeen Riaz; Fan Li; Alex W Hewitt; Peter van Wijngaarden; Gregory J. Dusting

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3261. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2019

CRISPR/Cas-mediated base editing of the AMD high-risk Y402H complement factor H variant

Alex W Hewitt; Peter Tran; Mohd Khairul Nizam Mohd Khalid; Alice Pébay; Anthony L Cook; Helena Liang; Raymond Wong; Jamie E Craig; Guei-Sheung Liu; Sandy Hung

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4947. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2019

Peripapillary RNFL loss precedes Macular GCIPL loss in glaucoma with lower intraocular pressure.

Henry Nicholas Marshall; Nicholas H Andrew; Emmanuelle Souzeau; Bronwyn Ridge; Jude Fitzgerald; Mona Awadalla; Kathryn P Burdon; Paul Healey; Ashish Agar; Anna Galanopoulos; Alex W Hewitt; Stuart Graham; John Landers; Robert James Casson; Jamie E Craig

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3921. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2019

Glaucoma polygenic risk score predicts treatment intensity and RNFL loss in glaucoma suspects

Ayub Qassim; Mark Hassall; Xikun Han; Henry Nicholas Marshall; Mona S Awadalla; Stuart L Graham; Paul R Healey; Ashish Agar; John Landers; Anna Galanopoulos; Robert James Casson; Alex W Hewitt; Stuart MacGregor; Jamie E Craig

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2832. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2019

Comparison of CRISPR/Cas endonuclease gene editing efficiency of retinal cells in vivo

Fan Li; Kristof Wing; Jiang-Hui Wang; James Bender; Chi D Luu; Jinying Chen; Vivienne Lu; Qi Wang; Qinyi Lu; Peter Tran; Kaylene Young; Anna King; Sandy Hung; Guei-Sheung Liu; Alex W Hewitt

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4226. doi: https://doi.org/

Glaucoma September 2018

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma

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Larry N. Singh; Jonathan G. Crowston; M. Isabel G. Lopez Sanchez; Nicole J. Van Bergen; Lisa S. Kearns; Alex W. Hewitt; Seyhan Yazar; David A. Mackey; Douglas C. Wallace; Ian A. Trounce
TAGS: glaucoma, disease susceptibility, open-angle glaucoma, dna, mitochondrial
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4598-4602. doi: https://doi.org/10.1167/iovs.18-25085

Includes: Supplemental Content

Genetics August 2018

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect

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Sherin Shaaban; Sarah MacKinnon; Caroline Andrews; Sandra E. Staffieri; Gail D. E. Maconachie; Wai-Man Chan; Mary C. Whitman; Sarah U. Morton; Seyhan Yazar; Stuart MacGregor; James E. Elder; Elias I. Traboulsi; Irene Gottlob; Alex W. Hewitt; Strabismus Genetics Research Consortium; David G. Hunter; David A. Mackey; Elizabeth C. Engle
TAGS: meta-analysis, esotropia, cohort studies, disease susceptibility, genome, parent, single nucleotide polymorphism, strabismus, genetics, genome-wide association study
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4054-4064. doi: https://doi.org/10.1167/iovs.18-24082

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

119 loci influencing intraocular pressure provide new insight into primary open angle glaucoma susceptibility and age of onset.

Jamie E. Craig; Alex W. Hewitt; David Mackey; Stuart L Graham; Paul R Healey; Andrew JR White; John Landers; Robert Casson; Emmanuelle Souzeau; Kathryn P Burdon; Puya Gharahkhani; Stuart MacGregor

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1177. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

The relationship between female reproductive factors and optic disc parameters in young female adults

Samantha Lee; Seyhan Yazar; Louis R. Pasquale; Paul Sanfilippo; Alex W. Hewitt; Martha Hickey; Rachel Skinner; David Mackey

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2732. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

A genome-wide association study for keratoconus identifies novel risk loci

Kathryn P Burdon; Bennet McComish; Paul N. Baird; Yelena Bykhovskaya; Andrea Richardson-Wynd; Colin E Willoughby; Xiaohui Li; Srujana Sahebjada; Stuart MacGregor; Sionne Lucas; Jerome I Rotter; Richard A Mills; Alex W. Hewitt; Yaron Rabinowitz; Jamie E. Craig

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4470. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

Effect of uteroglobin on trabecular meshwork cell contraction

Esther Ashworth Briggs; Stephen Myers; Alex W. Hewitt; Anthony Cook

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3519. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

Refining retinal ganglion cell (RGC) differentiation from human pluripotent stem cells (hPSCs)

Maciej Daniszewski; Duncan Crombie; Louise Rooney; Alison Conquest; Alex W. Hewitt; Alice Pebay

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3746. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2018

An update of the prevalence of myopia in an older Australian population

David Mackey; Gareth Lingham; Samantha Lee; Michael Hunter; Diane Wood; Alex W. Hewitt; Paul Mitchell; Hugh R Taylor; Seyhan Yazar

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3954. doi: https://doi.org/

Articles February 2018

Crowd-sourced Ontology for Photoleukocoria: Identifying Common Internet Search Terms for a Potentially Important Pediatric Ophthalmic Sign

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Sandra E. Staffieri; Lisa S. Kearns; Paul G. Sanfilippo; Jamie E. Craig; David A. Mackey; Alex W. Hewitt
TAGS: internet, pediatrics, retinoblastoma, eye, help-seeking behavior
Trans. Vis. Sci. Tech.. 2018; 7(1):18. doi: https://doi.org/10.1167/tvst.7.1.18

Includes: Supplemental Content

Glaucoma February 2018

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets

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Jessica N. Cooke Bailey; Puya Gharahkhani; Jae H. Kang; Mariusz Butkiewicz; David A. Sullivan; Robert N. Weinreb; Hugues Aschard; R. Rand Allingham; Allison Ashley-Koch; Richard K. Lee; Sayoko E. Moroi; Murray H. Brilliant; Gadi Wollstein; Joel S. Schuman; John H. Fingert; Donald L. Budenz; Tony Realini; Terry Gaasterland; William K. Scott; Kuldev Singh; Arthur J. Sit; Robert P. Igo, Jr; Yeunjoo E. Song; Lisa Hark; Robert Ritch; Douglas J. Rhee; Douglas Vollrath; Donald J. Zack; Felipe Medeiros; Thasarat S. Vajaranant; Daniel I. Chasman; William G. Christen; Margaret A. Pericak-Vance; Yutao Liu; Peter Kraft; Julia E. Richards; Bernard A. Rosner; Michael A. Hauser; Jamie E. Craig; Kathryn P. Burdon; Alex W. Hewitt; David A. Mackey; Jonathan L. Haines; Stuart MacGregor; Janey L. Wiggs; Louis R. Pasquale; for the Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) Consortium
TAGS: testosterone, metabolism, polymorphism, glaucoma, genes, open-angle glaucoma, datasets
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):629-636. doi: https://doi.org/10.1167/iovs.17-22708

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Differences in epigenetic age of ocular tissue and the implications for eye disease.

Alex W Hewitt; Vikrant Singh; Vania Januar; Alexandra Sexton-Oates; Jamie E Craig; Richard Saffery

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1845. doi: https://doi.org/

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MicroRNA-Related Genetic Variants Are Associated With Diabetic Retinopathy in Type 1 Diabetes Mellitus

A glaucoma polygenic risk score strongly associated with disease prediction and treatment intensity.

Associations between optic disc measures and obstructive sleep apnoea in young adults

The correlation between Glaucoma polygenic risk score and IOP measured by Icare® HOME tonometry within and outside of office hours.

MicroRNA-143 plays a protective role in ischemia-induced retinal neovascularization

CRISPR/Cas-mediated base editing of the AMD high-risk Y402H complement factor H variant

Peripapillary RNFL loss precedes Macular GCIPL loss in glaucoma with lower intraocular pressure.

Glaucoma polygenic risk score predicts treatment intensity and RNFL loss in glaucoma suspects

Comparison of CRISPR/Cas endonuclease gene editing efficiency of retinal cells in vivo

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma

Genome-Wide Association Study Identifies a Susceptibility Locus for Comitant Esotropia and Suggests a Parent-of-Origin Effect

119 loci influencing intraocular pressure provide new insight into primary open angle glaucoma susceptibility and age of onset.

The relationship between female reproductive factors and optic disc parameters in young female adults

A genome-wide association study for keratoconus identifies novel risk loci

Effect of uteroglobin on trabecular meshwork cell contraction

Refining retinal ganglion cell (RGC) differentiation from human pluripotent stem cells (hPSCs)

An update of the prevalence of myopia in an older Australian population

Crowd-sourced Ontology for Photoleukocoria: Identifying Common Internet Search Terms for a Potentially Important Pediatric Ophthalmic Sign

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets

Differences in epigenetic age of ocular tissue and the implications for eye disease.

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