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ARVO Annual Meeting Abstract June 2022

Photoreceptor and RPE co-expression of a dominant mutant polymerase gamma subunit 1 leads to accelerated retinal degeneration in wild type mice

Cristhian J Ildefonso; Raela Ridley; Erin Walsh; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1933 – F0351. doi:

ARVO Annual Meeting Abstract June 2022

Inhibition of Ryanodine Receptor 1 Reduces Endoplasmic Reticulum (ER) Stress and Promotes ER Protein Degradation in Cyclic Nucleotide-gated Channel Deficiency

Xi-Qin Ding; Fan Yang; Hongwei Ma; Rekha Garg; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1778 – F0327. doi:

ARVO Annual Meeting Abstract June 2022

Impact of prolonged oxidative stress in the retinal pigment epithelium (RPE) on the photoreceptors in an animal model of dry-AMD.

Manas R Biswal; Glenn Prazere Lobo; Mallika Valapala; Ryan J Paulson; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3035 – F0406. doi:

ARVO Annual Meeting Abstract June 2021

MODELING ACCELERATED RETINAL AGING USING A DOMINANT MUTANT OF THE DNA POLYMERASE GAMMA SUB-UNIT 1

Cristhian J Ildefonso; Erin Walsh; Raela Brianne Ridley; Ahmed Jafri; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):264. doi:

ARVO Annual Meeting Abstract June 2021

Buspirone is protective against oxidative stress induced changes in cell culture and animal models of RPE oxidative injury

Manas R Biswal; Ryan J Paulson; Riddhi Vichare; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3277. doi:

ARVO Annual Meeting Abstract June 2021

R9-SOCS1-KIR Peptide Abrogates Lipopolysaccharide Mediated Inflammation: Implications for the Treatment of Endotoxin Induced Uveitis

Chulbul M Ahmed; Anil P Patel; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3451. doi:

Articles March 2021

Corneal Application of R9-SOCS1-KIR Peptide Alleviates Endotoxin-Induced Uveitis

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Chulbul M. Ahmed; Anil P. Patel; Cristhian J. Ildefonso; Howard M. Johnson; Alfred S. Lewin
TAGS: peptides, socs1 gene, suppressor of cytokine signaling 1 protein, uveitis, endotoxins, mice, cornea
Trans. Vis. Sci. Tech.. 2021; 10(3):25. doi: https://doi.org/10.1167/tvst.10.3.25

ARVO Annual Meeting Abstract June 2020

Acute Subclinical Systemic Inflammation Activates Neuroprotective Mechanisms In Degenerating Mouse Retina

Raela Ridley; Erin Walsh; Brianna Bowman Young; Ahmed Jafri; Alfred S Lewin; Cristhian J Ildefonso

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1376. doi:

ARVO Annual Meeting Abstract June 2020

Development of an Allele-Independent Gene Replacement Therapy for Best Vitelliform Macular Dystrophy Using RNAi Technology

Brianna Bowman Young; Karina E Guziewicz; Alfred S Lewin; william W hauswirth; Cristhian Ildefonso

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2457. doi:

ARVO Annual Meeting Abstract June 2020

RETINAL EXPRESSION OF THE NF-KB INHIBITORY GENE M013 DECREASES THE RATE OF RETINAL DEGENERATION OF A GEOGRAPHIC ATROPHY MOUSE MODEL

Cristhian J Ildefonso; Brianna Bowman Young; Raela B Ridley; Erin Walsh; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4304. doi:

ARVO Annual Meeting Abstract June 2020

An Allele-Independent Gene Therapy Strategy Induces Rod Function in a Transgenic Swine Model of Autosomal Dominant Retinitis Pigmentosa

archana jalligampala; James Fransen; Jennifer Noel; Gobinda Pangeni; Maha Haleem Jabbar; William W Hauswirth; Alfred S Lewin; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4484. doi:

Articles December 2019

SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa

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Chulbul M. Ahmed; Brian T. Dwyer; Alla Romashko; Steve Van Adestine; Eun-Hee Park; Zhen Lou; Devin Welty; Serene Josiah; Anneli Savinainen; Bohong Zhang; Alfred S. Lewin
TAGS: molecular chaperones, opsin, rhodopsin, animal model, retinitis pigmentosa, pharmacology, mice, photoreceptors
Trans. Vis. Sci. Tech.. 2019; 8(6):30. doi: https://doi.org/10.1167/tvst.8.6.30

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Repurposing an orally available drug to protect RPE cells and treat geographic atrophy

Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4217. doi:

ARVO Annual Meeting Abstract July 2019

A Cell Penetrating Peptide from Type I Interferon Protects Mice Against Experimental Autoimmune Uveitis

Alfred S Lewin; Chulbul M Ahmed; Howard M Johnson

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):244. doi:

Retina November 2018

Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa

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Michael T. Massengill; Brianna Young; Deep Patel; Farwa Jafri; Ernesto Sabogal; Neil Ash; Hong Li; Cristhian J. Ildefonso; Alfred S. Lewin
TAGS: mice, retina, retinitis pigmentosa, rhodopsin, spectral domain-optical coherence tomography, retinal degeneration, outcome measures, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5417-5430. doi: https://doi.org/10.1167/iovs.18-25345

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Superoxide Dismutase 2 Deletion in Retinal Pigment Epithelium (RPE) Results in Age and Light-Dependent Mitochondrial Oxidative Stress and RPE-damage

Emily Brown; Alfred S Lewin; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2453. doi:

ARVO Annual Meeting Abstract July 2018

A Novel Hypoxia-Regulated And Cell -Specific Gene Therapy Elicits Reduced Choroidal Neovascularization

Manas Ranjan Biswal; Howard M Prentice; George W Smith; Ping Zhu; Tong Yao; C Kathleen Dorey; Alfred S Lewin; Janet C Blanks

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3965. doi:

ARVO Annual Meeting Abstract June 2017

A SOCS1 peptide alleviates inflammation and associated damage to barrier properties in ARPE-19 cells

Chulbul M Ahmed; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1092. doi:

ARVO Annual Meeting Abstract June 2017

Development of SERP1 and SERP2 anti-inflammatory serpins from Myxoma virus for use in gene therapy for ocular inflammation

Virginia White; Sriram Ambadapadi; Matthew Amontree; Brianna M Bowman; Cristhian J Ildefonso; Alexandra Lucas; D Grant McFadden; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1929. doi:

ARVO Annual Meeting Abstract June 2017

Outcome measures for BEST1 gene augmentation therapy: restoration of RPE-photoreceptor interface homeostasis

Karina E Guziewicz; William A Beltran; Artur V Cideciyan; Valerie Liliane Dufour; Andras M Komaromy; Emily McTish; Alfred S Lewin; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2273. doi:

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Photoreceptor and RPE co-expression of a dominant mutant polymerase gamma subunit 1 leads to accelerated retinal degeneration in wild type mice

Inhibition of Ryanodine Receptor 1 Reduces Endoplasmic Reticulum (ER) Stress and Promotes ER Protein Degradation in Cyclic Nucleotide-gated Channel Deficiency

Impact of prolonged oxidative stress in the retinal pigment epithelium (RPE) on the photoreceptors in an animal model of dry-AMD.

MODELING ACCELERATED RETINAL AGING USING A DOMINANT MUTANT OF THE DNA POLYMERASE GAMMA SUB-UNIT 1

Buspirone is protective against oxidative stress induced changes in cell culture and animal models of RPE oxidative injury

R9-SOCS1-KIR Peptide Abrogates Lipopolysaccharide Mediated Inflammation: Implications for the Treatment of Endotoxin Induced Uveitis

Corneal Application of R9-SOCS1-KIR Peptide Alleviates Endotoxin-Induced Uveitis

Acute Subclinical Systemic Inflammation Activates Neuroprotective Mechanisms In Degenerating Mouse Retina

Development of an Allele-Independent Gene Replacement Therapy for Best Vitelliform Macular Dystrophy Using RNAi Technology

RETINAL EXPRESSION OF THE NF-KB INHIBITORY GENE M013 DECREASES THE RATE OF RETINAL DEGENERATION OF A GEOGRAPHIC ATROPHY MOUSE MODEL

An Allele-Independent Gene Therapy Strategy Induces Rod Function in a Transgenic Swine Model of Autosomal Dominant Retinitis Pigmentosa

SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa

Repurposing an orally available drug to protect RPE cells and treat geographic atrophy

A Cell Penetrating Peptide from Type I Interferon Protects Mice Against Experimental Autoimmune Uveitis

Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa

Superoxide Dismutase 2 Deletion in Retinal Pigment Epithelium (RPE) Results in Age and Light-Dependent Mitochondrial Oxidative Stress and RPE-damage

A Novel Hypoxia-Regulated And Cell -Specific Gene Therapy Elicits Reduced Choroidal Neovascularization

A SOCS1 peptide alleviates inflammation and associated damage to barrier properties in ARPE-19 cells

Development of SERP1 and SERP2 anti-inflammatory serpins from Myxoma virus for use in gene therapy for ocular inflammation

Outcome measures for BEST1 gene augmentation therapy: restoration of RPE-photoreceptor interface homeostasis

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