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ARVO Annual Meeting Abstract July 2018

Superoxide Dismutase 2 Deletion in Retinal Pigment Epithelium (RPE) Results in Age and Light-Dependent Mitochondrial Oxidative Stress and RPE-damage

Emily Brown; Alfred S Lewin; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2453. doi:

ARVO Annual Meeting Abstract July 2018

A Novel Hypoxia-Regulated And Cell -Specific Gene Therapy Elicits Reduced Choroidal Neovascularization

Manas Ranjan Biswal; Howard M Prentice; George W Smith; Ping Zhu; Tong Yao; C Kathleen Dorey; Alfred S Lewin; Janet C Blanks

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3965. doi:

ARVO Annual Meeting Abstract June 2017

Daily Zeaxanthin Supplementation Improves RPE Function in a Mouse Model of RPE Oxidative Stress

Manas Ranjan Biswal; Brad Justis; Ping Yang Han; Hong Li; C Kathleen Dorey; Dennis L Gierhart; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5900. doi:

ARVO Annual Meeting Abstract June 2017

AAV-mediated Knockdown and Replacement of Rhodopsin Protects Rods in a Canine Model of RHO -ADRP

William A Beltran; Artur V Cideciyan; Raghavi Sudharsan; Michael Massengill; Brian Rossmiller; Valerie Liliane Dufour; felipe Pompeo Marinho; Tatyana Appelbaum; Malgorzata Swider; Mychajlo S. Kosyk; Simone Iwabe; William W Hauswirth; Samuel G Jacobson; Alfred S Lewin; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4483. doi:

ARVO Annual Meeting Abstract June 2017

A SOCS1 peptide alleviates inflammation and associated damage to barrier properties in ARPE-19 cells

Chulbul M Ahmed; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1092. doi:

ARVO Annual Meeting Abstract June 2017

Gene Therapy with the Caspase Activation and Recruitment Domain (CARD) Slows the Retina Degeneration of the Sod2 Knock-Out Mouse Model of Geographic Atrophy

Cristhian J Ildefonso; Brianna M Bowman; Manas Ranjan Biswal; Chulbul M Ahmed; Qiuhong Li; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3387. doi:

ARVO Annual Meeting Abstract June 2017

Delivery of CR2-fH using AAV vector therapy as a treatment strategy in mouse model of choroidal neovascularization.

Baerbel Rohrer; Gloriane Schnabolk; Balasubramaniam Annamalai; Nathaniel Parsons; Elisabeth Obert; Alfred S Lewin; Stephen Tomlinson

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3388. doi:

ARVO Annual Meeting Abstract June 2017

Deletion of Mitochondrial Antioxidant Enzyme Sod2 Induces Light-Dependent Retinal Degeneration with Aging

Emily Brown; John D Ash; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2294. doi:

ARVO Annual Meeting Abstract June 2017

Outcome measures for BEST1 gene augmentation therapy: restoration of RPE-photoreceptor interface homeostasis

Karina E Guziewicz; William A Beltran; Artur V Cideciyan; Valerie Liliane Dufour; Andras M Komaromy; Emily McTish; Alfred S Lewin; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2273. doi:

ARVO Annual Meeting Abstract June 2017

Development of SERP1 and SERP2 anti-inflammatory serpins from Myxoma virus for use in gene therapy for ocular inflammation

Virginia White; Sriram Ambadapadi; Matthew Amontree; Brianna M Bowman; Cristhian J Ildefonso; Alexandra Lucas; D Grant McFadden; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1929. doi:

ARVO Annual Meeting Abstract June 2017

Tandem Delivery of Short Hairpin RNAs and Rhodopsin cDNA to Combat Retinal Degeneration in Autosomal Dominant Retinitis Pigmentosa

Michael Massengill; Deep Patel; William A Beltran; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4082. doi:

Biochemistry and Molecular Biology February 2017

Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD

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Manas R. Biswal; Pingyang Han; Ping Zhu; Zhaoyang Wang; Hong Li; Cristhian J. Ildefonso; Alfred S. Lewin
TAGS: antioxidants, oxidative stress, gene therapy, disease vectors, electroretinography, injection of therapeutic agent, photoreceptors, eye, mice, retina, spatial vectors, spectral-domain optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):1237-1245. doi: 10.1167/iovs.16-21272

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Constitutive Activation of Mechanistic Target of Rapamycin Complex 1 (mTORC1) Caused Degeneration of the Retinal Pigment Epithelium (RPE)

Pei Xu; Bo Yu; Bo Long; Zhen-Yang Zhao; Alfred S Lewin; Ralph Nichols; Theodore G Wensel; Yan Chen

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6533. doi:

ARVO Annual Meeting Abstract September 2016

Early Sub-retinal Delivery of AAV1- Sod2 Protects the Retina in a Mouse Model of Progressive Retinal Degeneration.

Manas Ranjan Biswal; Cristhian J Ildefonso; Bradley D Justis; Hong Li; Pingyang Han; Ping Zhu; Lindsey Elizabeth Buz; Chulbul M Ahmed; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6548. doi:

ARVO Annual Meeting Abstract September 2016

The 5HT1a Agonist Xaliproden Exhibits Anti-oxidant and Anti-inflammatory Properties and Protects the Retina in a Mouse Model of Geographic Atrophy

Alfred S Lewin; Chulbul M Ahmed; Manas Ranjan Biswal; Hong Li; Pingyang Han

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4428. doi:

ARVO Annual Meeting Abstract September 2016

Gene Therapy Utilizing Short Hairpin RNAs for Autosomal Dominant Retinitis Pigmentosa

Michael Massengill; William W Hauswirth; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):139. doi:

ARVO Annual Meeting Abstract September 2016

Induction of Endogenous Nrf2 Activation in the Retina Partially Protects from Oxidative Stress and Inflammation

Cristhian J Ildefonso; Emily E Brown; Ryo Iwata; Chulbul M Ahmed; Michael Massengill; Manas Biswal; Shannon Elizabeth Boye; William W Hauswirth; John Ash; Qiuhong Li; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5399. doi:

Retinal Cell Biology February 2016

MRI of Retinal Free Radical Production With Laminar Resolution In Vivo

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Bruce A. Berkowitz; Alfred S. Lewin; Manas R. Biswal; Bryce X. Bredell; Christopher Davis; Robin Roberts
TAGS: magnetic resonance imaging, free radicals, mice
Invest. Ophthalmol. Vis. Sci.. 2016; 57(2):577-585. doi: 10.1167/iovs.15-18972

Biochemistry and Molecular Biology February 2016

Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide

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Cristhian J. Ildefonso; Henrique Jaime; Emily E. Brown; Ryo L. Iwata; Chulbul M. Ahmed; Michael T. Massengill; Manas R. Biswal; Shannon E. Boye; William W. Hauswirth; John D. Ash; Qiuhong Li; Alfred S. Lewin
TAGS: oxidative stress, polymerase chain reaction, disease vectors, electroretinography, fluorescent antibody technique, genes, peptides, uveitis, eye, mice, proteins, retina, signal pathway, signal transduction pathways, spatial vectors
Invest. Ophthalmol. Vis. Sci.. 2016; 57(2):372-386. doi: 10.1167/iovs.15-17703

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Delaying Retinal Degeneration in a Mouse Model of Geographic Atrophy: An Antioxidant Gene Therapy Approach.

Manas Ranjan Biswal; Cristhian J Ildefonso; Brian P Rossmiller; Haoyu Mao; Hong Li; Ping Han; Ping Zhu; Yao Tong; Giovani Quinones Valdez; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3189. doi:

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Superoxide Dismutase 2 Deletion in Retinal Pigment Epithelium (RPE) Results in Age and Light-Dependent Mitochondrial Oxidative Stress and RPE-damage

A Novel Hypoxia-Regulated And Cell -Specific Gene Therapy Elicits Reduced Choroidal Neovascularization

Daily Zeaxanthin Supplementation Improves RPE Function in a Mouse Model of RPE Oxidative Stress

AAV-mediated Knockdown and Replacement of Rhodopsin Protects Rods in a Canine Model of RHO -ADRP

A SOCS1 peptide alleviates inflammation and associated damage to barrier properties in ARPE-19 cells

Gene Therapy with the Caspase Activation and Recruitment Domain (CARD) Slows the Retina Degeneration of the Sod2 Knock-Out Mouse Model of Geographic Atrophy

Delivery of CR2-fH using AAV vector therapy as a treatment strategy in mouse model of choroidal neovascularization.

Deletion of Mitochondrial Antioxidant Enzyme Sod2 Induces Light-Dependent Retinal Degeneration with Aging

Outcome measures for BEST1 gene augmentation therapy: restoration of RPE-photoreceptor interface homeostasis

Development of SERP1 and SERP2 anti-inflammatory serpins from Myxoma virus for use in gene therapy for ocular inflammation

Tandem Delivery of Short Hairpin RNAs and Rhodopsin cDNA to Combat Retinal Degeneration in Autosomal Dominant Retinitis Pigmentosa

Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD

Constitutive Activation of Mechanistic Target of Rapamycin Complex 1 (mTORC1) Caused Degeneration of the Retinal Pigment Epithelium (RPE)

Early Sub-retinal Delivery of AAV1- Sod2 Protects the Retina in a Mouse Model of Progressive Retinal Degeneration.

The 5HT1a Agonist Xaliproden Exhibits Anti-oxidant and Anti-inflammatory Properties and Protects the Retina in a Mouse Model of Geographic Atrophy

Gene Therapy Utilizing Short Hairpin RNAs for Autosomal Dominant Retinitis Pigmentosa

Induction of Endogenous Nrf2 Activation in the Retina Partially Protects from Oxidative Stress and Inflammation

MRI of Retinal Free Radical Production With Laminar Resolution In Vivo

Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide

Delaying Retinal Degeneration in a Mouse Model of Geographic Atrophy: An Antioxidant Gene Therapy Approach.

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