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ARVO Annual Meeting Abstract June 2022

The phase III REFLECT trial: efficacy of bilateral gene therapy for Leber hereditary optic neuropathy (LHON) is maintained 2 years post administration

Patrick Yu-Wai-Man; Nancy Newman; Prem S Subramanian; Mark Moster; An-Guor Wang; Sean Donahue; Bart Leroy; Valerio Carelli; Valerie Biousse; Catherine Vignal-Clermont; Alfredo A Sadun; Gema Fernandez; Elizabeth Fortin; Rudrani Banik; Magali Taiel; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):434. doi:

Articles October 2021

Benefit of Stimulus Size V Perimetry for Patients With a Dense Central Scotoma From Leber’s Hereditary Optic Neuropathy

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Alvaro J. Mejia-Vergara; Alfredo A. Sadun; Alexander F. Chen; Michael F. Smith; Michael Wall; Rustum Karanjia
TAGS: optic atrophy, hereditary, leber, optic nerve disorders, perimetry, scotoma, central
Trans. Vis. Sci. Tech.. 2021; 10(12):31. doi: https://doi.org/10.1167/tvst.10.12.31

ARVO Annual Meeting Abstract June 2021

Evaluation of the efficacy of rAAV2/2- ND4 gene therapy for Leber hereditary optic neuropathy compared with the natural history

Patrick Yu-Wai-Man; Nancy J Newman; Valerio Carelli; Mark Moster; Catherine Vignal-Clermont; Alfredo A Sadun; Chiara La Morgia; Francesco Bandello; Lorena Castillo Campillo; Stephanie Leruez; Dean Cestari; Robert Foroozan; Rustum Karanjia; Laure Blouin; Magali Taiel; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2676. doi:

ARVO Annual Meeting Abstract June 2020

Human Retinal Ganglion Cells Expressing an RGR Opsin: An Immunohistochemical Study

Fred N Ross-Cisneros; Ernesto Barron; Zhaoxia Zhang; Henry K. W. Fong; Alfredo A. Sadun

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):725. doi:

ARVO Annual Meeting Abstract June 2020

RGR Opsin in Pigmented Cells in the Ciliary Body and Ciliary Marginal Zone

Zhaoxia Zhang; Fred N Ross-Cisneros; Ernesto Barron; Alfredo A. Sadun; Henry KW Fong

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3455. doi:

ARVO Annual Meeting Abstract June 2020

Longitudinal Analysis of Photopic Negative Response in Carriers and Affected Members of the 11778 SOA-BR Leber’s Hereditary Optic Neuropathy Pedigree

Adriana Berezovsky; Rustum Karanjia; Paula Y Sacai; Milton Nunes Moraes Filho; Arthur Fernandes; Gabriel Izan Santos Botelho; Rubens Belfort Jr.; Valerio Carelli; Alfredo A. Sadun; Solange Rios Salomao

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5050. doi:

ARVO Annual Meeting Abstract June 2020

Photopic Negative Response and Retinal Nerve Fiber Layer Measured by OCT in Brazilian Families with Leber’s Hereditary Optic Neuropathy

Gabriel Izan Santos Botelho; Solange Rios Salomao; Celia Harumi Tengan; Daniel M Rocha; Paula B Silva; Paula Y Sacai; Felipo V Moura; Arthur Fernandes; Rustum Karanjia; Alfredo A. Sadun; Rubens Belfort Jr.; Adriana Berezovsky

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5051. doi:

ARVO Annual Meeting Abstract June 2020

Bilateral Visual Improvement with Unilateral Gene Therapy for Leber Hereditary Optic Neuropathy (LHON)

Patrick Yu-Wai-Man; Nancy J Newman; Valerio Carelli; Valerie Biousse; Alfredo A. Sadun; Mark L Moster; Catherine Vignal-Clermont; Robert C Sergott; Thomas Klopstock klopstock; Laure Blouin; Magali Taiel; Pierre Burguière; Caroline Chevalier; Barrett Katz; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5181. doi:

ARVO Annual Meeting Abstract June 2020

Modulation of mouse retinal ganglion cell excitability by mitochondrial reactive oxygen species

Ben Smith; Cyrus McHugh; Alfredo Sadun; Nicholas Brecha; Steven A Barnes

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):767. doi:

ARVO Annual Meeting Abstract July 2019

In Vivo Assessment of Retinal Ganglion Cells in Human Preclinical Alzheimer’s disease using Electroretinography.

Christian Felix; Samuel Asanad; Rustum Karanjia; Michael Harrington; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6443. doi:

ARVO Annual Meeting Abstract July 2019

Pupillary light response and sleep-wake activity in preclinical Alzheimer’s disease

Angela Oh; Giulia Amore; William Sultan; Rustum Karanjia; Michael Harrington; Chiara La Morgia; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6460. doi:

ARVO Annual Meeting Abstract July 2019

Pattern ERG as an Objective Outcome Measure of Contrast Sensitivity in Patients with Multifocal Intraocular Lenses

Jack TIAN; Martin Garcia; Alfredo A Sadun; Stuart G Coupland; Rustum Karanjia; Kenneth Lu

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6466. doi:

ARVO Annual Meeting Abstract July 2019

Rat model of posterior ischemic optic neuropathy

Fred N. Ross-Cisneros; William Charles Sultan; Samuel Asanad; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2265. doi:

ARVO Annual Meeting Abstract July 2019

Elamipretide (MTP-131) Topical Ophthalmic Solution for the Treatment of Leber's Hereditary Optic Neuropathy

Rustum Karanjia; Stuart G Coupland; Martin Garcia; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2266. doi:

ARVO Annual Meeting Abstract July 2019

Blue light stimulation of melanopsin retinal ganglion cells reveals visual cortex activation and modulates cognition in LHON patients

Chiara La Morgia; Stefania Evangelisti; Claudia Testa; Gilles Vandewalle; Claudio Bianchini; David Neil Manners; Paola Fantazzini; Michele Carbonelli; Alfredo A Sadun; Caterina Tonon; Raffaele Lodi; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2272. doi:

ARVO Annual Meeting Abstract July 2019

Photopic Negative Response in Healthy Adults: Normative Values and Test-Retest Reliability

Adriana Berezovsky; Tatiane N Bueno; Nivea Nunes Ferraz; Paula Y Sacai; Gabriel I Botelho; Arthur Fernandes; Stuart Coupland; Rubens Belfort Jr.; Alfredo A Sadun; Rustum Karanjia; Solange Rios Salomao

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2499. doi:

ARVO Annual Meeting Abstract July 2019

Photopic Negative Response in Carriers and Affected Patients with Leber’s Hereditary Optic Neuropathy

Melanie R Lalonde; Ange-Lynca Kantungane; Alfredo A Sadun; Stuart G Coupland; Rustum Karanjia

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4242. doi:

ARVO Annual Meeting Abstract July 2019

rAAV2/2- ND4 for the Treatment of Leber Hereditary Optic Neuropathy (LHON): 72-Week Data from the REVERSE Phase III Clinical Trial

Patrick Yu-Wai-Man; Mark Moster; Alfredo A Sadun; Thomas Klopstock; Catherine Vignal-Clermont; Nancy J Newman; Robert C Sergott; Valerio Carelli; Caroline Chevalier; Laure Blouin; Magali Taiel; Barrett Katz; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4806. doi:

ARVO Annual Meeting Abstract July 2019

Localization of exon-skipping RGR-d opsin and C5b-9 deposits in Bruch’s membrane of mice

Xuan Bao; Zhaoxia Zhang; Fred N. Ross-Cisneros; Alfredo A Sadun; Christopher Buser; Xiaohua Li; Mingwei Zhao; Henry KW Fong

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4921. doi:

ARVO Annual Meeting Abstract July 2019

The Retina in Preclinical Alzheimer’s Disease: Degeneration of the Eye Before the Brain

Samuel Asanad; Michele Fantini; William Charles Sultan; Marco Nassisi; Christian Felix; Jessica Wu; Rustum Karanjia; Fred N. Ross-Cisneros; Michael Harrington; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5946. doi:

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The phase III REFLECT trial: efficacy of bilateral gene therapy for Leber hereditary optic neuropathy (LHON) is maintained 2 years post administration

Benefit of Stimulus Size V Perimetry for Patients With a Dense Central Scotoma From Leber’s Hereditary Optic Neuropathy

Evaluation of the efficacy of rAAV2/2- ND4 gene therapy for Leber hereditary optic neuropathy compared with the natural history

Human Retinal Ganglion Cells Expressing an RGR Opsin: An Immunohistochemical Study

RGR Opsin in Pigmented Cells in the Ciliary Body and Ciliary Marginal Zone

Longitudinal Analysis of Photopic Negative Response in Carriers and Affected Members of the 11778 SOA-BR Leber’s Hereditary Optic Neuropathy Pedigree

Photopic Negative Response and Retinal Nerve Fiber Layer Measured by OCT in Brazilian Families with Leber’s Hereditary Optic Neuropathy

Bilateral Visual Improvement with Unilateral Gene Therapy for Leber Hereditary Optic Neuropathy (LHON)

Modulation of mouse retinal ganglion cell excitability by mitochondrial reactive oxygen species

In Vivo Assessment of Retinal Ganglion Cells in Human Preclinical Alzheimer’s disease using Electroretinography.

Pupillary light response and sleep-wake activity in preclinical Alzheimer’s disease

Pattern ERG as an Objective Outcome Measure of Contrast Sensitivity in Patients with Multifocal Intraocular Lenses

Rat model of posterior ischemic optic neuropathy

Elamipretide (MTP-131) Topical Ophthalmic Solution for the Treatment of Leber's Hereditary Optic Neuropathy

Blue light stimulation of melanopsin retinal ganglion cells reveals visual cortex activation and modulates cognition in LHON patients

Photopic Negative Response in Healthy Adults: Normative Values and Test-Retest Reliability

Photopic Negative Response in Carriers and Affected Patients with Leber’s Hereditary Optic Neuropathy

rAAV2/2- ND4 for the Treatment of Leber Hereditary Optic Neuropathy (LHON): 72-Week Data from the REVERSE Phase III Clinical Trial

Localization of exon-skipping RGR-d opsin and C5b-9 deposits in Bruch’s membrane of mice

The Retina in Preclinical Alzheimer’s Disease: Degeneration of the Eye Before the Brain

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