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Articles March 2021

Reliability of Retinal Pathology Quantification in Age-Related Macular Degeneration: Implications for Clinical Trials and Machine Learning Applications

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Philipp L. Müller; Bart Liefers; Tim Treis; Filipa Gomes Rodrigues; Abraham Olvera-Barrios; Bobby Paul; Narendra Dhingra; Andrew Lotery; Clare Bailey; Paul Taylor; Clarisa I. Sánchez; Adnan Tufail
TAGS: age-related macular degeneration, machine learning, pathology, reliability, drusen, diagnostic imaging
Trans. Vis. Sci. Tech.. 2021; 10(3):4. doi: https://doi.org/10.1167/tvst.10.3.4

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

C-Reactive protein levels and the Outer retina in a large cohort study: UK Biobank

Sharon Yu Lin Chua; Paul J Foster; Andrew J Lotery; Tariq Aslam; Charles A Reisman; Tunde Peto; Catherine A Egan; Baljean Dhillon; Praveen J Patel

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2313. doi:

ARVO Annual Meeting Abstract June 2020

Real world outcomes for aflibercept in diabetic macula edema

Haralabos Eleftheriadis; Irene Mary Stratton; James S Talks; Peter Henry Scanlon; Shahram Kashani; Andrew J Lotery; Clare Bailey; Raj Mukherjee; Usha Chakravarthy

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3290. doi:

ARVO Annual Meeting Abstract June 2020

Phenome-wide association analysis on risk variants for age-related macular degeneration reveals shared genetic influences with a wide range of disorders: the Million Veteran Program

Robert Igo; Tyler G Kinzy; Christopher W. Halladay; Dana C. Crawford; Paul B Greenberg; Jack M. Sullivan; Steven J. Fliesler; Wen-Chih Wu; Helene Choquet; Karina Patasova; Eric Jorgenson; Pirro G Hysi; Andrew J Lotery; Jessica Cooke Bailey; Neal S. Peachey; Sudha K Iyengar

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3518. doi:

ARVO Annual Meeting Abstract June 2020

Implementing digital applications for self-monitoring of visual function in the MONARCH study: technological and practical challenges.

Ruth E Hogg; Robin Wickens; Charlene Treanor; Abby O'Connell; Lucy Culliford; Chris Rogers; Eleanor Gidman; Tunde Peto; Paul C Knox; Ben Burton; Andrew J Lotery; Sobha Sivaprasad; Michael Donnelly; Barney Reeves

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3079. doi:

Genetics June 2020

Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration

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Thomas M. Hallam; Kevin J. Marchbank; Claire L. Harris; Clive Osmond; Victoria G. Shuttleworth; Helen Griffiths; Angela J. Cree; David Kavanagh; Andrew J. Lotery
TAGS: age-related macular degeneration, cohort studies, complement factor i, cultural formulation interview, fibrinogen, genetics, plasma, regression analysis, genetic analysis
Invest. Ophthalmol. Vis. Sci.. 2020; 61(6):18. doi: https://doi.org/10.1167/iovs.61.6.18

Includes: Supplemental Content

Clinical and Epidemiologic Research May 2020

Ambient Air Pollution Associations with Retinal Morphology in the UK Biobank

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Sharon Y. L. Chua; Anthony P. Khawaja; Andrew D. Dick; James Morgan; Baljean Dhillon; Andrew J. Lotery; Nicholas G. Strouthidis; Charles Reisman; Tunde Peto; Peng T. Khaw; Paul J. Foster; Praveen J. Patel; on behalf of The UK Biobank Eye and Vision Consortium
TAGS: air pollution, biobanks, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):32. doi: https://doi.org/10.1167/iovs.61.5.32

ARVO Annual Meeting Abstract July 2019

Modelling Sorsby’s Fundus Dystrophy using patient-derived iPSC-RPE

Jennifer Dewing; David R. G. Christensen; Heidi Hongisto; Jennifer Scott; Ben Jenkins; Angela Jane Cree; Heli Skottman; J. Arjuna Ratnayaka; Andrew Lotery

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):424. doi:

ARVO Annual Meeting Abstract July 2019

Characterization of the retinal phenotype of the C57BL/6-c2J mouse model of human oculocutaneous albinism: implications for treatment development

Jennifer Ann Scott; Aida Sanchez-Bretano; Helen Griffiths; Jon Ward; Chiamaka Dibigbou; Flavie Soubigou; James Edward Self; Andrew Lotery; J. Arjuna Ratnayaka; Helena Lee

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):529. doi:

ARVO Annual Meeting Abstract July 2019

Proof of concept for oral Levodopa treatment in rescuing retinal morphology and visual function in a murine model of human albinism

Helena Lee; Jennifer Scott; Helen Griffiths; James Edward Self; Andrew Lotery

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):530. doi:

ARVO Annual Meeting Abstract July 2019

Long-term clinical management of neovascular AMD and visual acuity outcome in IVAN trial participants

Barney Reeves; Rebecca Evans; Simon P Harding; Andrew Lotery; Usha Chakravarthy

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1214. doi:

ARVO Annual Meeting Abstract July 2019

Preliminary results in 18 patients undergoing retinal gene therapy for X-linked retinitis pigmentosa with codon-optimized AAV8-RPGR

Robert E MacLaren; Janet L Davis; Ninel Gregori; Jasmina Cehajic-Kapetanovic; Byron L Lam; Andrew Lotery; Cristina Martinez-Fernandez dela Camara; Anika Nanda; Anna Paola Salvetti; Paulo Stanga; Kanmin Xue

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1329. doi:

ARVO Annual Meeting Abstract July 2019

Oral human-equivalent L-DOPA/Carbidopa dosages administered during the postnatal critical period of neuroplasticity rescues retinal morphology and visual function in a mouse model of human albinism

Aida Sanchez-Bretano; Jennifer Ann Scott; Tutte Newall; Savannah Lynn; Helen Griffiths; Ahmed Salman; Andrew Lotery; J. Arjuna Ratnayaka; James Edward Self; Helena Lee

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1393. doi:

ARVO Annual Meeting Abstract July 2019

Aflibercept in the real world – an EPR based clinical audit of patients with diabetic macular edema from 21 UK hospitals

Sajjad Mahmood; Irene Mary Stratton; Raj Mukherjee; James S Talks; Clare Bailey; Andrew Lotery; Shahram Kashani; Faruque Ghanchi; Salim Natha; Peter Henry Scanlon

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2626. doi:

ARVO Annual Meeting Abstract July 2019

Aflibercept in the real world – are the visual outcomes worse in patients with diabetic macular edema who have had a cataract operation?

Irene Mary Stratton; Peter Henry Scanlon; James S Talks; Usha Chakravarthy; Raj Mukherjee; Faruque Ghanchi; Sajjad Mahmood; Andrew Lotery

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2637. doi:

ARVO Annual Meeting Abstract July 2019

The Influence of Corticosteroids on Choroidal Endothelial Cells in Central Serous Chorioretinopathy

Rebecca Kaye; David R. G. Christensen; Andrew Lotery

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4326. doi:

ARVO Annual Meeting Abstract July 2019

Designing a clinical trial to evaluate the safety and efficacy of oral soraprazan in Stargardt Disease

Carel C B Hoyng; Andrew Lotery; Katarina Stingl; Camiel Boon; Maurizio Parodi; Patty Dhooge; Tobias Peters; Wolfgang Klein; Mario G Fsadni; Hans Müller; Oliver Jungmann

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5704. doi:

ARVO Annual Meeting Abstract July 2019

Acceptability of OCT Angiography: A multicentre OCT Angiography NEtwork (OCTANE) study.

Faruque Ghanchi; Corinne Fulcher; Sobha Sivaprasad; Konstantinos Balaskas; Richard Peter Gale; Gabriella De Salvo; James S Talks; Andrew Lotery; Ian A Pearce

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3477. doi:

ARVO Annual Meeting Abstract July 2018

Lysosomal impairment in the Retinal Pigment Epithelium (RPE) - a pathway of damage in the ageing retina

Eloise Keeling; David A. Johnston; David S. Chatelet; David Tumbarello; Andrew Lotery; J. Arjuna Ratnayaka

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4487. doi:

ARVO Annual Meeting Abstract July 2018

Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial

Robert E MacLaren; Kanmin Xue; Alun R Barnard; Maria In?s Patrício; Thomas L Edwards; Susan Downes; Andrew Lotery; Graeme Black; Andrew Webster; Jasleen K Jolly; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1195. doi:

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Reliability of Retinal Pathology Quantification in Age-Related Macular Degeneration: Implications for Clinical Trials and Machine Learning Applications

C-Reactive protein levels and the Outer retina in a large cohort study: UK Biobank

Real world outcomes for aflibercept in diabetic macula edema

Phenome-wide association analysis on risk variants for age-related macular degeneration reveals shared genetic influences with a wide range of disorders: the Million Veteran Program

Implementing digital applications for self-monitoring of visual function in the MONARCH study: technological and practical challenges.

Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration

Ambient Air Pollution Associations with Retinal Morphology in the UK Biobank

Modelling Sorsby’s Fundus Dystrophy using patient-derived iPSC-RPE

Characterization of the retinal phenotype of the C57BL/6-c2J mouse model of human oculocutaneous albinism: implications for treatment development

Proof of concept for oral Levodopa treatment in rescuing retinal morphology and visual function in a murine model of human albinism

Long-term clinical management of neovascular AMD and visual acuity outcome in IVAN trial participants

Preliminary results in 18 patients undergoing retinal gene therapy for X-linked retinitis pigmentosa with codon-optimized AAV8-RPGR

Oral human-equivalent L-DOPA/Carbidopa dosages administered during the postnatal critical period of neuroplasticity rescues retinal morphology and visual function in a mouse model of human albinism

Aflibercept in the real world – an EPR based clinical audit of patients with diabetic macular edema from 21 UK hospitals

Aflibercept in the real world – are the visual outcomes worse in patients with diabetic macular edema who have had a cataract operation?

The Influence of Corticosteroids on Choroidal Endothelial Cells in Central Serous Chorioretinopathy

Designing a clinical trial to evaluate the safety and efficacy of oral soraprazan in Stargardt Disease

Acceptability of OCT Angiography: A multicentre OCT Angiography NEtwork (OCTANE) study.

Lysosomal impairment in the Retinal Pigment Epithelium (RPE) - a pathway of damage in the ageing retina

Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial

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