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ARVO Annual Meeting Abstract June 2024

Poly Sialic-Acid Coated Nanoparticle attenuates Neovascularization, Inflammation and Complement Activity in AMD

Diyan Patel; Sheri L Peterson; Victor G. Sendra; Anitha Krishnan; Amit Lad; David Callanan; Tarek Hassan; Chris Scott; Michael Tolentino; mohammed Genead

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):720.

ARVO Annual Meeting Abstract June 2024

Poly Sialic-Acid Coated Nanoparticle Suppresses Complement Activity

Sheri L Peterson; Diyan Patel; Anitha Krishnan; Ali Khanehzar; Amit Lad; David Callanan; Tarek Hassan; Chris Scott; Michael Tolentino; Mohamed Genead

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):717.

ARVO Annual Meeting Abstract June 2024

PolySia Nanoparticle Modulates M1 Macrophages Response Through Siglec Agonism as Mechanism of Action for Macular Degeneration Treatment

Victor G. Sendra; Diyan Patel; Samantha Gallaher; Anitha Krishnan; David Callanan; Tarek Hassan; Chris Scott; Michael Tolentino; mohammed Genead

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):564.

ARVO Annual Meeting Abstract June 2024

Novel sialic acid coated Nanoparticle AVD-104 demonstrates pre-clinical ocular and systemic safety

Anitha Krishnan; Ravinder Earla; Victor G. Sendra; Amit Lad; David Callanan; Tarek Hassan; Derek kunimoto; Michael Tolentino; mohammed Genead

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3806.

ARVO Annual Meeting Abstract June 2024

Treatment with soluble Fas ligand prevents disease progression in the DBA/2J chronic mouse model of glaucoma

Sarah Dickman; Anitha Krishnan; Bhupender Verma; Ann Marshak-Rothstein; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):946.

ARVO Annual Meeting Abstract June 2023

Targeting Self-Recognition Pattern Receptors on Retina Immune Cells with an Engineered Glycan-coated Nanoparticle as a Novel Therapy for Nonexudative AMD

Diyan Patel; Amit Lad; David Callanan; Tarek Hassan; Michael Tolentino; Christopher Scott; Mohamed Genead; Anitha Krishnan

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2959.

ARVO Annual Meeting Abstract June 2023

Modulation of Retinal Inflammatory Macrophages by Sialic-Acid Coated Nanoparticles as Novel mechanism for Nonexudative AMD Treatment

Anitha Krishnan; Diyan Patel; Victor G. Sendra; Amit Lad; David Callanan; Tarek Hassan; Michael Tolentino; Christopher Scott; Mohamed Genead

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2730.

ARVO Annual Meeting Abstract June 2023

Post injury treatment with intravitreal AAV2-soluble Fas ligand restores retinal microglia homeostasis and rescues retinal ganglion cell function in a mouse model of glaucoma

Meredith S Gregory-Ksander; Anitha Krishnan; Maleeka Shrestha; Khoa Nguyen; Ann Marshak-Rotstein

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2583.

ARVO Annual Meeting Abstract June 2023

Modulation of Macrophages and Complement Dysfunction in Nonexudative Age- Related Macular Degeneration Utilizing a Sialic-acid Coated Nanoparticle

Baruch D Kuppermann; David Callanan; Tarek Hassan; Michael Tolentino; Christopher Scott; Mohamed Genead; Anitha Krishnan

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3239.

ARVO Annual Meeting Abstract June 2022

Anti-inflammatory role of a glycan-coated nanoparticle in modulating macrophages and complement in non-exudative AMD

Anitha Krishnan; Rajesh Shinde; Michael Tolentino; David Callanan; Derek Kunimoto; Mohamed Genead

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3163 – F0437.

ARVO Annual Meeting Abstract June 2020

Reversal of aging-induced and glaucoma-induced vision loss by in vivo epigenetic reprogramming

Bruce Ksander; Yuancheng Lu; Anitha Krishnan; Benedikt Brommer; Xiao Tian; Margarita Meer; Daniel Vera; Chen Wang; Qiurui Zeng; Doudou Yu; Steve Horvath; Meredith S Gregory-Ksander; Zhigang He; David Sinclair

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2364.

ARVO Annual Meeting Abstract June 2020

InflaMab: A novel NLRP3 Inflammasome inhibitor provides neuroprotection in a mouse model of glaucoma

Melody Chemaly; Anitha Krishnan; Anthony J Bjourson; Aaron Peace; Meredith S Gregory-Ksander; Victoria McGilligan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2365.

ARVO Annual Meeting Abstract June 2020

Intravitreal administration of AAV2.soluble Fas ligand gene therapy following glaucoma injury restores retinal ganglion cell function and stops disease progression

Meredith S Gregory-Ksander; Maleeka Shrestha; Khoa Nguyen; Ann Marshak-Rothstein; Anitha Krishnan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2366.

ARVO Annual Meeting Abstract July 2019

Pharmacologic inhibition of the NLRP3 inflammasome - a novel neuroprotective therapy for glaucoma

Anitha Krishnan; Malvika Dua; Claire H Mitchell; Wennan Lu; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2256.

ARVO Annual Meeting Abstract July 2019

Fas signaling triggers glial-mediated neuroinflammation in glaucoma

Meredith S Gregory-Ksander; Wennan Lu; Claire H Mitchell; Andrew Kocab; David N Zacks; Anitha Krishnan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2257.

ARVO Annual Meeting Abstract July 2018

A small peptide inhibitor of the Fas receptor prevents axon degeneration and death of retinal ganglion cells in a microbead-induced mouse model of glaucoma.

Meredith S Gregory-Ksander; Andrew J Kocab; David N Zacks; Anitha krishnan

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6139.

ARVO Annual Meeting Abstract June 2017

Destructive neuroinflammation triggered by activation of the NLRP3 inflammasome in the glaucomatous optic nerve head

Meredith S Gregory-Ksander; Fei Fei; anitha krishnan; Te-Chen Tzeng; Deepa Subramanian; Douglas Golenbock; Ann Marshak-Rothstein; Bruce Ksander

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2021.

ARVO Annual Meeting Abstract September 2016

Soluble Fas ligand provides long-term protection in a chronic mouse model of glaucoma by inhibiting glial activation, inflammation, and apoptosis

Meredith S Gregory-Ksander; Fei Fei; Ann Marshak-Rothstein; Bruce Ksander; Anitha Krishnan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

ARVO Annual Meeting Abstract June 2015

Preventing glaucoma by blocking activation of the NLRP3 inflammasome in the optic nerve head

Fei Fei; Anitha Krishnan; Ann Marshak Rothstein; Bruce R Ksander; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3485.

ARVO Annual Meeting Abstract June 2015

Gene therapy treatment with AAV-soluble Fas ligand protects retinal ganglion cells during development of Glaucoma

Anitha Krishnan; Fei Fei; Alexander Jones; Bruce R Ksander; Ann Marshak Rothstein; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2594.

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