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Genetics December 2020

The Effect of Genetic Variants Associated With Age-Related Macular Degeneration Varies With Age

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Tina Schick; Laura Lorés-Motta; Lebriz Altay; Lars G. Fritsche; Anneke I. den Hollander; Sascha Fauser

Invest. Ophthalmol. Vis. Sci.. 2020; 61(14):17. doi: https://doi.org/10.1167/iovs.61.14.17

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2020

Genes Involved in Energy Metabolism Are Differentially Expressed During the Day–Night Cycle in Murine Retinal Pigment Epithelium

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Elja M. M. Louer; Guoqiang Yi; Claudia Carmone; Joris Robben; Henk G. Stunnenberg; Anneke I. den Hollander; Peter M. T. Deen
TAGS: genes, mice, rhythm, metabolism, retinal pigment epithelium, energy metabolism, sequence analysis, rna
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):49. doi: https://doi.org/10.1167/iovs.61.5.49

Includes: Supplemental Content

Retina March 2020

Complement Activation Levels Are Related to Disease Stage in AMD

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Thomas J. Heesterbeek; Yara T. E. Lechanteur; Laura Lorés-Motta; Tina Schick; Mohamed R. Daha; Lebriz Altay; Sandra Liakopoulos; Dzenita Smailhodzic; Anneke I. den Hollander; Carel B. Hoyng; Eiko K. de Jong; B. Jeroen Klevering
TAGS: complement activation, complement system proteins, choroidal neovascularization
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):18. doi: https://doi.org/10.1167/iovs.61.3.18

Includes: Supplemental Content

Retina August 2019

Elevated Steroid Hormone Levels in Active Chronic Central Serous Chorioretinopathy

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Rosa L. Schellevis; Lebriz Altay; Asha Kalisingh; Timo W. F. Mulders; Vasilena Sitnilska; Carel B. Hoyng; Camiel J. F. Boon; Joannes M. M. Groenewoud; Eiko K. de Jong; Anneke I. den Hollander
TAGS: central serous chorioretinopathy, steroid hormone, steroids, hormones
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3407-3413. doi: https://doi.org/10.1167/iovs.19-26781

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Metabolomics in Age-related Macular Degeneration: The EYE-RISK Consortium

Ilhan Erkin Acar; Magda Meester; Laura Lorés de Motta; Daniel Pauleikhoff; Sascha Fauser; Carel C B Hoyng; Cecile DelCourt; Caroline C W Klaver; Tessel E Galesloot; Anneke I Den Hollander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1004. doi:

ARVO Annual Meeting Abstract July 2019

Risk factors for Fellow Eye Progression in Patients with Unilateral Exudative Age-Related Macular Degeneration

Julia Lemke; Vasilena Sitnilska; Caroline Gietzelt; Tina Schick; Carel C B Hoyng; Anneke I Den Hollander; Sascha Fauser; Lebriz Altay

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1134. doi:

ARVO Annual Meeting Abstract July 2019

Non-genetic risk factors for age-related macular degeneration in nonagenarians

Vasilena Sitnilska; Tina Schick; Anneke I Den Hollander; Carel C B Hoyng; Sascha Fauser; Lebriz Altay

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1135. doi:

ARVO Annual Meeting Abstract July 2019

Development of a Genotyping Assay for Age-Related Macular Degeneration: The EYE-RISK Consortium

Anita de Breuk; Ilhan Erkin Acar; Magda Meester; Mascha MVAP Schijvenaars; Eveline Kersten; Jordi Mones; Daniel Pauleikhoff; Rufino Silva; Sascha Fauser; Carel C B Hoyng; Cecile DelCourt; Caroline C W Klaver; Marieke JH Coenen; Anneke I Den Hollander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2955. doi:

ARVO Annual Meeting Abstract July 2019

Subclinical choroidal neovascularizations in fellow-eyes of exudative age-related macular degeneration patients show a decrease in retinal sensitivity over time

Thomas Johannes Heesterbeek; Yara Lechanteur; Anita de Breuk; Anneke I Den Hollander; Jeroen Klevering; Thomas Theelen; Carel C B Hoyng

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3484. doi:

ARVO Annual Meeting Abstract July 2019

Factor H-Related Protein 4 (FHR-4) drives complement dysregulation in age-related macular degeneration

Valentina Cipriani; Laura Lorés de Motta; Fan He; Dina Fathalla; Selina McHarg; Nadhim Bayatti; Ilhan Erkin Acar; Carel C B Hoyng; Sascha Fauser; Anthony Moore; John RW Yates; Paul Morgan; Eiko de Jong; Anneke I Den Hollander; Paul N Bishop; Simon J Clark

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3870. doi:

ARVO Annual Meeting Abstract July 2019

Whole genome methylation profiling of retinal pigment epithelium reveals differential methylation and gene expression associated with AMD

Louise Frances Porter; Neil Saptarshi; Yongxiang Fang; Sonika Rathi; Anneke I Den Hollander; Eiko de Jong; Simon Clark; Paul N Bishop; Timothy W Olsen; Triantafillos Liloglu; Venkata Ramana Murthy Chavali; Luminita Paraoan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4247. doi:

ARVO Annual Meeting Abstract July 2019

The effect of genetic variants associated with age-related macular degeneration decreases in individuals aged 90 years and older. Findings from the International AMD Genomics Consortium

Laura Lorés de Motta; Tina Schick; Lebriz Altay; Carel C B Hoyng; Anneke I Den Hollander; Sascha Fauser

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4248. doi:

ARVO Annual Meeting Abstract July 2019

RNA-seq analysis of retinal pigment epithelium indicates elevated ATP production at a different circadian time point than lipid metabolism

Elja Louer; Guoqiang Yi; Henk Stunnenberg; Anneke I Den Hollander; Peter Deen

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4917. doi:

ARVO Annual Meeting Abstract July 2019

Expression levels of rare missense variants in CFI found in age-related macular degeneration, atypical uremic syndrome or both diseases

Sarah de Jong; Elena Volokhina; Sara Nilsson; Bjorn Bakker; Eiko de Jong; Lambert van den Heuvel; Anna Blom; Anneke I Den Hollander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4914. doi:

Genetics March 2019

Macular Dystrophy and Cone-Rod Dystrophy Caused by Mutations in the RP1 Gene: Extending the RP1 Disease Spectrum

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Sanne K. Verbakel; Ramon A. C. van Huet; Anneke I. den Hollander; Maartje J. Geerlings; Eveline Kersten; B. Jeroen Klevering; Caroline C. W. Klaver; Astrid S. Plomp; Nieneke L. Wesseling; Arthur A. B. Bergen; Konstantinos Nikopoulos; Carlo Rivolta; Yasuhiro Ikeda; Koh-Hei Sonoda; Yuko Wada; Camiel J. F. Boon; Toru Nakazawa; Carel B. Hoyng; Koji M. Nishiguchi
TAGS: age-related macular degeneration, genes, macular dystrophy, mutation, retinitis pigmentosa, phenotype, family, genetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1192-1203. doi: https://doi.org/10.1167/iovs.18-26084

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Whole-exome sequencing in age-related macular degeneration identifies rare protein-altering variants in COL8A1, a component of Bruch’s membrane

Anneke I Den Hollander; Jordi Corominas; Johanna Maria Colijn; Maartje Geerlings; Sascha Fauser; Eiko de Jong; Cornelia van Duijn; Carel C B Hoyng; Caroline C W Klaver

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):789. doi:

ARVO Annual Meeting Abstract July 2018

Progression to late AMD: Role of SDOCT-biomarkers in patients with drusenoid PED

Julia Lemke; Vasilena Sitnilska; Eveline Kersten; Tina Schick; Philip Enders; Carel C B Hoyng; Anneke I Den Hollander; Sascha Fauser; Lebriz Altay

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2377. doi:

ARVO Annual Meeting Abstract July 2018

Is ‘good’ cholesterol bad for Age-related Macular Degeneration? Evidence from the EYE-RISK and E3 Consortia

Johanna Maria Colijn; Eveline Kersten; Ayse Demirkan; Audrey Cougnard-Gregoire; Timo Verzijden; Magda A. Meester; Benedicte MJ Merle; Johannes R Vingerling; Anneke I Den Hollander; Cornelia van Duijn; Cecile DelCourt; Caroline C W Klaver

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3013. doi:

ARVO Annual Meeting Abstract July 2018

An amino acid motif in HLA-DRβ1 distinguishes patients with uveitis in juvenile idiopathic arthritis

Anne-Mieke Haasnoot; M.W. Schilham; S Kamphuis; P Hissink-muller; Arnd Heiligenhaus; D Foell; K Minden; R.A. Ophoff; Timothy Radstake; Anneke I Den Hollander; T Reinards; Sanne Hiddingh; N. Schalij-Delofs; Joke de Boer; S Pulit; Jonas Kuiper

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3492. doi:

ARVO Annual Meeting Abstract July 2018

Genome-wide association study underlines the role of the complement system in chronic central serous chorioretinopathy

Rosa Schellevis; Elon H. Van Dijk; Myrte Breukink; Lebriz Altay; Bjorn Bakker; Bobby Koeleman; Lambertus Kiemeney; Dorine Swinkels; Jan Keunen; Sascha Fauser; Carel C B Hoyng; Anneke I Den Hollander; Camiel Boon; Eiko de Jong

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4983. doi:

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The Effect of Genetic Variants Associated With Age-Related Macular Degeneration Varies With Age

Genes Involved in Energy Metabolism Are Differentially Expressed During the Day–Night Cycle in Murine Retinal Pigment Epithelium

Complement Activation Levels Are Related to Disease Stage in AMD

Elevated Steroid Hormone Levels in Active Chronic Central Serous Chorioretinopathy

Metabolomics in Age-related Macular Degeneration: The EYE-RISK Consortium

Risk factors for Fellow Eye Progression in Patients with Unilateral Exudative Age-Related Macular Degeneration

Non-genetic risk factors for age-related macular degeneration in nonagenarians

Development of a Genotyping Assay for Age-Related Macular Degeneration: The EYE-RISK Consortium

Subclinical choroidal neovascularizations in fellow-eyes of exudative age-related macular degeneration patients show a decrease in retinal sensitivity over time

Factor H-Related Protein 4 (FHR-4) drives complement dysregulation in age-related macular degeneration

Whole genome methylation profiling of retinal pigment epithelium reveals differential methylation and gene expression associated with AMD

The effect of genetic variants associated with age-related macular degeneration decreases in individuals aged 90 years and older. Findings from the International AMD Genomics Consortium

RNA-seq analysis of retinal pigment epithelium indicates elevated ATP production at a different circadian time point than lipid metabolism

Expression levels of rare missense variants in CFI found in age-related macular degeneration, atypical uremic syndrome or both diseases

Macular Dystrophy and Cone-Rod Dystrophy Caused by Mutations in the RP1 Gene: Extending the RP1 Disease Spectrum

Whole-exome sequencing in age-related macular degeneration identifies rare protein-altering variants in COL8A1, a component of Bruch’s membrane

Progression to late AMD: Role of SDOCT-biomarkers in patients with drusenoid PED

Is ‘good’ cholesterol bad for Age-related Macular Degeneration? Evidence from the EYE-RISK and E3 Consortia

An amino acid motif in HLA-DRβ1 distinguishes patients with uveitis in juvenile idiopathic arthritis

Genome-wide association study underlines the role of the complement system in chronic central serous chorioretinopathy

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