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Genetics September 2020

The Role of Chromosome X in Intraocular Pressure Variation and Sex-Specific Effects

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Mark J. Simcoe; Anthony P. Khawaja; Omar A. Mahroo; Christopher J. Hammond; Pirro G. Hysi; for the UK Biobank Eye and Vision Consortium
TAGS: intraocular pressure, open-angle glaucoma, x chromosomes, single nucleotide polymorphism, biobanks, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2020; 61(11):20. doi: https://doi.org/10.1167/iovs.61.11.20

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Long-term experience of XEN® trans-scleral gelatin stent insertion in a large specialist glaucoma center

Yusrah Shweikh; Georgios Vakros; Alexander Baneke; Sam Cooke; Anthimos Vlavianos; Anthony P Khawaja; Keith Barton; Hari Jayaram

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):941. doi:

ARVO Annual Meeting Abstract June 2020

A multiomics investigation of risk factors associated with intraocular pressure in the general population

Pirro G Hysi; Anthony P Khawaja; Christopher Hammond

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):979. doi:

ARVO Annual Meeting Abstract June 2020

Evidence for a causal link between pseudoexfoliation syndrome and myocardial infarction using Mendelian randomization

Marianne T Kennedy Neary; Oliver J Kennedy; George Davey Smith; Pirro G Hysi; Louis R Pasquale; Janey Wiggs; Anthony P Khawaja

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2738. doi:

ARVO Annual Meeting Abstract June 2020

Diabetic retinopathy prevalence and associations in a large population-based cohort: a three-way data linkage study

Alasdair Warwick; Robert Luben; Tjebo Heeren; Abraham Olvera Barrios; Sharon Yu Lin Chua; Paul J Foster; Adnan Tufail; Catherine A Egan; Anthony P Khawaja

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3833. doi:

Clinical and Epidemiologic Research May 2020

Ambient Air Pollution Associations with Retinal Morphology in the UK Biobank

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Sharon Y. L. Chua; Anthony P. Khawaja; Andrew D. Dick; James Morgan; Baljean Dhillon; Andrew J. Lotery; Nicholas G. Strouthidis; Charles Reisman; Tunde Peto; Peng T. Khaw; Paul J. Foster; Praveen J. Patel; on behalf of The UK Biobank Eye and Vision Consortium
TAGS: air pollution, biobanks, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):32. doi: https://doi.org/10.1167/iovs.61.5.32

Glaucoma November 2019

The Relationship Between Ambient Atmospheric Fine Particulate Matter (PM 2.5 ) and Glaucoma in a Large Community Cohort

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Sharon Y. L. Chua; Anthony P. Khawaja; James Morgan; Nicholas Strouthidis; Charles Reisman; Andrew D. Dick; Peng T. Khaw; Praveen J. Patel; Paul J. Foster; for the UK Biobank Eye and Vision Consortium
TAGS: cohort studies, glaucoma, particulate matter, community, intraocular pressure, self-report, air pollution
Invest. Ophthalmol. Vis. Sci.. 2019; 60(14):4915-4923. doi: https://doi.org/10.1167/iovs.19-28346

ARVO Annual Meeting Abstract July 2019

Retinal neurodegeneration and brain MRI markers: The UK Biobank

Sharon Yu Lin Chua; Anthony P Khawaja; Charles A Reisman; Qi Yang; Axel Petzold; Peng Tee Khaw; Paul J Foster; Praveen Patel

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1847. doi:

ARVO Annual Meeting Abstract July 2019

Genome-wide association study of macular ganglion cell complex thickness in 41,504 participants of the UK Biobank study

Hannah Currant; Tomas Fitzgerald; Pirro G Hysi; Charles A Reisman; Qi Yang; Christopher J Hammond; Peng Tee Khaw; Paul J Foster; Praveen Patel; Ewan Birney; Anthony P Khawaja

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2830. doi:

ARVO Annual Meeting Abstract July 2019

Integrative analysis of GWAS and eQTLs proposes new genetic associations and causal genes for Primary Open Angle Glaucoma

Ayellet Segre; Andrew Hamel; John Rouhana; Anthony P Khawaja; Mark James Simcoe; Christopher J Hammond; Pirro G Hysi; GTEx consortium; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4252. doi:

ARVO Annual Meeting Abstract July 2019

Gene-drug interactions alter response to prostaglandin analogue treatment of high intraocular pressure and glaucoma

Pirro G Hysi; Mark James Simcoe; Anthony P Khawaja; Christopher J Hammond

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5223. doi:

ARVO Annual Meeting Abstract July 2019

GWAS of corneal biomechanics identifies over 200 novel associated loci providing additional insight into the genetic aetiology of ocular disease

Mark James Simcoe; Anthony P Khawaja; Christopher J Hammond; Pirro G Hysi

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5227. doi:

ARVO Annual Meeting Abstract July 2019

Clinically relevant artefactual intraocular pressure lowering resulting from corneal biomechanical changes under latanoprost treatment: data from the UKGTS.

Soledad Aguilar Munoa; Jibran Mohamed-Noriega; Anthony P Khawaja; David F Garway-Heath

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2250. doi:

Genetics July 2019

Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma

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Adriana I. Iglesias; Jue Sheng Ong; Anthony P. Khawaja; Puya Gharahkhani; Milly S. Tedja; Virginie J. M. Verhoeven; Pieter W. M. Bonnemaijer; Roger C. W. Wolfs; Terri L. Young; Nomdo M. Jansonius; Jamie E. Craig; Dwight Stambolian; Cornelia M. van Duijn; Stuart MacGregor; Caroline C. W. Klaver; for the International Glaucoma Genetics Consortium (IGGC) and Consortium for Refractive Error and Myopia (CREAM)
TAGS: myopia, open-angle glaucoma, genetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3142-3149. doi: https://doi.org/10.1167/iovs.18-26231

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Genome-wide association study of intraocular pressure identifies 83 novel loci

Anthony P Khawaja; Jessica Cooke Bailey; Mark James Simcoe; Robert P Igo; Louis R. Pasquale; Paul J Foster; Janey L Wiggs; Christopher J Hammond; Pirro G Hysi

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1178. doi:

ARVO Annual Meeting Abstract July 2018

Association of corneal biomechanical factors, IOPg and IOPcc with primary open angle glaucoma in a large community cohort: The EPIC-Norfolk Eye Study

Michelle P Y Chan; Anthony P Khawaja; David C Broadway; Jennifer L Y Yip; Robert Luben; Shabina Hayat; Kay-Tee Khaw; Paul J Foster

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1998. doi:

ARVO Annual Meeting Abstract July 2018

Assessment of shared heritability between spherical equivalent and the age of the first spectacle wear in UK Biobank cohort

Karina Patasova; Pirro G Hysi; Christopher J Hammond; Robert Wojciechowski; Phillippa Cumberland; Anthony P Khawaja; Jugnoo Rahi

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1826. doi:

ARVO Annual Meeting Abstract June 2017

Exome-wide analyses of glaucoma-related endophenotypes in 19,700 individuals

Adriana I Iglesias; Anthony P Khawaja; Pieter W.M. Bonnemaijer; Abhishek Nag; Pirro G Hysi; Christopher J Hammond; Najaf Amin; Caroline Klaver; Paul J Foster; Cornelia van Duijn

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2134. doi:

ARVO Annual Meeting Abstract June 2017

A protective association of selective serotonin reuptake inhibitors and a harmful association of calcium channel blockers for primary open-angle glaucoma identified in a healthcare database analysis

Anthony P Khawaja; Thaddeus P Dryja; Zhongyuan Wei; Dongying Song; Haijun Tian; Kristijan Kahler; Wei Zheng

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3710. doi:

ARVO Annual Meeting Abstract September 2016

Genome-wide association study identifies new loci associated with corneal biomechanical properties

Anthony P Khawaja; Pirro G Hysi; David C Broadway; David F Garway-Heath; Shabina Hayat; Robert Luben; Stephen J Tuft; Nicholas Wareham; Kay-Tee Khaw; Christopher J Hammond; Paul J Foster

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

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The Role of Chromosome X in Intraocular Pressure Variation and Sex-Specific Effects

Long-term experience of XEN® trans-scleral gelatin stent insertion in a large specialist glaucoma center

A multiomics investigation of risk factors associated with intraocular pressure in the general population

Evidence for a causal link between pseudoexfoliation syndrome and myocardial infarction using Mendelian randomization

Diabetic retinopathy prevalence and associations in a large population-based cohort: a three-way data linkage study

Ambient Air Pollution Associations with Retinal Morphology in the UK Biobank

The Relationship Between Ambient Atmospheric Fine Particulate Matter (PM 2.5 ) and Glaucoma in a Large Community Cohort

Retinal neurodegeneration and brain MRI markers: The UK Biobank

Genome-wide association study of macular ganglion cell complex thickness in 41,504 participants of the UK Biobank study

Integrative analysis of GWAS and eQTLs proposes new genetic associations and causal genes for Primary Open Angle Glaucoma

Gene-drug interactions alter response to prostaglandin analogue treatment of high intraocular pressure and glaucoma

GWAS of corneal biomechanics identifies over 200 novel associated loci providing additional insight into the genetic aetiology of ocular disease

Clinically relevant artefactual intraocular pressure lowering resulting from corneal biomechanical changes under latanoprost treatment: data from the UKGTS.

Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma

Genome-wide association study of intraocular pressure identifies 83 novel loci

Association of corneal biomechanical factors, IOPg and IOPcc with primary open angle glaucoma in a large community cohort: The EPIC-Norfolk Eye Study

Assessment of shared heritability between spherical equivalent and the age of the first spectacle wear in UK Biobank cohort

Exome-wide analyses of glaucoma-related endophenotypes in 19,700 individuals

A protective association of selective serotonin reuptake inhibitors and a harmful association of calcium channel blockers for primary open-angle glaucoma identified in a healthcare database analysis

Genome-wide association study identifies new loci associated with corneal biomechanical properties

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