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ARVO Annual Meeting Abstract June 2024

Delivering large genes using adeno-associated virus (AAV) and the CRE-lox DNA recombination system

Seongjin Seo; Poppy Datta; Kun Do Rhee; Rylee J Staudt; Jacob Thompson; Ying Hsu; Salma Hassan; Tyler Rankin; Arlene V Drack

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1030.

ARVO Annual Meeting Abstract June 2024

A candidate gene therapy vector delays vision loss in a mouse model of Bardet-Biedl Syndrome Type 10

Ying Hsu; Tyler Rankin; Brianna Lobeck; Tassos Georgiadis; Sophia Kleine Holthaus; Emily Kalmanek; Sarah Stanley; Jacob Thompson; Salma Hassan; Val Sheffield; Arlene V Drack

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6077.

ARVO Annual Meeting Abstract June 2024

Correlation of Flash Visual Evoked Potentials with Visual Acuity and Goldmann Visual Fields in Pediatric Patients with Inherited Retinal Disorders

Giulia Steuernagel Del Valle; Rose McGlauflin; Wanda L Pfeifer; Arlene V Drack

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5233.

Retina March 2024

Quantitative Foveal Structural Metrics as Predictors of Visual Acuity in Human Albinism

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Erica N. Woertz; Gelique D. Ayala; Niamh Wynne; Sergey Tarima; Serena Zacharias; Murray H. Brilliant; Taylor M. Dunn; Deborah Costakos; C. Gail Summers; Sasha Strul; Arlene V. Drack; Joseph Carroll
TAGS: albinism, foveal hypoplasia, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):3. https://doi.org/10.1167/iovs.65.3.3

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Resolution of retinal cysts following subretinal buffer injection in a mouse model of Juvenile X-linked Retinoschisis

Jacob Thompson; Ying Hsu; Ella Gehrke; Salma Hassan; Sara Kathryn Mayer; Angela Mahoney; Arlene V Drack

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):760.

ARVO Annual Meeting Abstract June 2023

Investigating the role of caspase-1 in a mouse model of juvenile X-linked retinoschisis

Araniko Pandey; Jacob Thompson; Ying Hsu; Sajag Bhattarai; Prajwal Gurung; Arlene V Drack

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5214.

ARVO Annual Meeting Abstract June 2022

Long-term safety and efficacy of sepofarsen in a Ph1b/2 INSIGHT extension trial in CEP290 -associated Leber congenital amaurosis (LCA10)

Stephen R Russell; Arlene V Drack; Artur V Cideciyan; Samuel G. Jacobson; Bart P Leroy; Caroline Van Cauwenbergh; Michael Schwartz; Aniz Girach

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):453.

ARVO Annual Meeting Abstract June 2022

Cone rescue with low titer subretinal gene replacement in the Rs1 mouse

Ella Gehrke; Jacob Thompson; Ying Hsu; Angela Mahoney; Arlene V Drack

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2613 – F0496.

ARVO Annual Meeting Abstract June 2022

Disrupted Macular Cone Post-Synaptic Circuitry is Related to Poor Vision in Albinism

Uma Balakrishnan; Niamh Wynne; Wanda Pfeifer; Joseph Carroll; Arlene V Drack

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3533.

ARVO Annual Meeting Abstract June 2022

Drosophila models of SNRNP200 -associated retinitis pigmentosa exhibit retinal apoptosis and abnormal electroretinograms

Sara Kathryn Mayer; Quinton Christenson; Arlene V Drack; Lori L Wallrath

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):737 – F0389.

Retina December 2021

Comparative Natural History of Visual Function From Patients With Biallelic Variants in BBS1 and BBS10

PDF

Monika K. Grudzinska Pechhacker; Samuel G. Jacobson; Arlene V. Drack; Matteo Di Scipio; Ine Strubbe; Wanda Pfeifer; Jacque L. Duncan; Helene Dollfus; Nathalie Goetz; Jean Muller; Andrea L. Vincent; Tomas S. Aleman; Anupreet Tumber; Caroline Van Cauwenbergh; Elfride De Baere; Emma Bedoukian; Bart P. Leroy; Jason T. Maynes; Francis L. Munier; Erika Tavares; Eman Saleh; Ajoy Vincent; Elise Heon
TAGS: natural history, phenotype, retinal degeneration, vision, cohort studies, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2021; 62(15):26. https://doi.org/10.1167/iovs.62.15.26

ARVO Annual Meeting Abstract June 2021

Subretinal gene replacement rescues retinal phenotype in BBS10 mouse

Arlene V Drack; Angela Mahoney; Sajag Bhattarai; Sara Mayer; Jacintha Thomas; Poppy Datta; Ying Hsu; Janelle Garrison; Elise Heon; Charles Searby; Luk H Vandenberghe; Seongjin Seo; Val Sheffield

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1178.

ARVO Annual Meeting Abstract June 2021

Safety and efficacy of sepofarsen in the second treated eye in a Ph1b/2 extension trial in Leber Congenital Amaurosis type 10 (LCA10)

Stephen R Russell; Arlene V Drack; Artur V Cideciyan; Samuel G Jacobson; Bart Leroy; Allen Ho; Caroline Van Cauwenbergh; Arun kumar Krishnan; Wilhelmina R. den Hollender; Adriana Hollestein-Havelaar; Mike Schwartz; Aniz Girach

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3317.

ARVO Annual Meeting Abstract June 2021

BBS10 knockout mouse exhibits developmental lack of cone function and recapitulates retinal degeneration.

Sara Mayer; Jacintha Thomas; Angela Mahoney; Sajag Bhattarai; Qihong Zhang; Elliot Stalter; Poppy Datta; Ying Hsu; Janelle Garrison; Charles Searby; Seongjin Seo; Val Sheffield; Arlene V Drack

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3070.

ARVO Annual Meeting Abstract June 2021

Five-Year Post-Injection Results of the Phase 3 Trial of Voretigene Neparvovec-rzyl in Biallelic RPE65 Mutation-Associated Inherited Retinal Disease

Jean Bennett; Stephen R Russell; Katherine A High; Arlene V Drack; Zi-Fan Yu; Daniel C Chung; Kathy Reape; Albert M Maguire

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3540.

ARVO Annual Meeting Abstract June 2021

Natural history study of visual function in patients with BBS1- and BBS10 -related retinal degeneration.

Monika Grudzinska Pechhacker; Samuel G Jacobson; Arlene V Drack; Matteo Di Scipio; Ine Stubbe; Jacque L Duncan; Helene Dollfus; Andrea L Vincent; Tomas S Aleman; Bart Leroy; Jason Maynes; Francis Munier; Erika Tavares; Eman Saleh; Ajoy Vincent; Elise Heon

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3284.

Articles May 2021

Examining Whether AOSLO-Based Foveal Cone Metrics in Achromatopsia and Albinism Are Representative of Foveal Cone Structure

PDF

Katie M. Litts; Erica N. Woertz; Niamh Wynne; Brian P. Brooks; Alicia Chacon; Thomas B. Connor, Jr.; Deborah Costakos; Alina Dumitrescu; Arlene V. Drack; Gerald A. Fishman; William W. Hauswirth; Christine N. Kay; Byron L. Lam; Michel Michaelides; Mark E. Pennesi; Kimberly E. Stepien; Sasha Strul; C. Gail Summers; Joseph Carroll
TAGS: achromatopsia, albinism, retinal cone, diagnostic imaging, mosaicism
Trans. Vis. Sci. Tech.. 2021; 10(6):22. https://doi.org/10.1167/tvst.10.6.22

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Retinal degeneration in BBS10 mice is ameliorated by subretinal gene replacement

Arlene V Drack; Sajag Bhattarai; Jacintha Thomas; Elliot Stalter; Poppy Datta; ying Hsu; Janelle Garrison; Charles Searby; Luk H Vandenberghe; Elise Heon; Seongjin Seo; Val C Sheffield

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1914.

ARVO Annual Meeting Abstract June 2020

Natural history study of visual function in patients with BBS1 and BBS10 -related Bardet-Biedl syndrome.

Monika Grudzinska Pechhacker; Samuel G Jacobson; Ine Strubbe; Jacque L Duncan; Arlene V Drack; Andrea L Vincent; Tomas Aleman; Caroline Van Cauwenbergh; Elfride De Baere; Helene Dollfus; Nathalie Goetz; Bart Peter Leroy; Ajoy Vincent; Elise Heon

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4463.

ARVO Annual Meeting Abstract June 2020

Towards an objective structural grading scheme of foveal hypoplasia in human albinism

Erica N. Woertz; Gelique Ayala; Niamh Wynne; Taylor M. Dunn; Deborah Costakos; C. Gail Summers; Sasha Strul; Arlene V Drack; Joseph Carroll

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5261.

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Delivering large genes using adeno-associated virus (AAV) and the CRE-lox DNA recombination system

A candidate gene therapy vector delays vision loss in a mouse model of Bardet-Biedl Syndrome Type 10

Correlation of Flash Visual Evoked Potentials with Visual Acuity and Goldmann Visual Fields in Pediatric Patients with Inherited Retinal Disorders

Quantitative Foveal Structural Metrics as Predictors of Visual Acuity in Human Albinism

Resolution of retinal cysts following subretinal buffer injection in a mouse model of Juvenile X-linked Retinoschisis

Investigating the role of caspase-1 in a mouse model of juvenile X-linked retinoschisis

Long-term safety and efficacy of sepofarsen in a Ph1b/2 INSIGHT extension trial in CEP290 -associated Leber congenital amaurosis (LCA10)

Cone rescue with low titer subretinal gene replacement in the Rs1 mouse

Disrupted Macular Cone Post-Synaptic Circuitry is Related to Poor Vision in Albinism

Drosophila models of SNRNP200 -associated retinitis pigmentosa exhibit retinal apoptosis and abnormal electroretinograms

Comparative Natural History of Visual Function From Patients With Biallelic Variants in BBS1 and BBS10

Subretinal gene replacement rescues retinal phenotype in BBS10 mouse

Safety and efficacy of sepofarsen in the second treated eye in a Ph1b/2 extension trial in Leber Congenital Amaurosis type 10 (LCA10)

BBS10 knockout mouse exhibits developmental lack of cone function and recapitulates retinal degeneration.

Five-Year Post-Injection Results of the Phase 3 Trial of Voretigene Neparvovec-rzyl in Biallelic RPE65 Mutation-Associated Inherited Retinal Disease

Natural history study of visual function in patients with BBS1- and BBS10 -related retinal degeneration.

Examining Whether AOSLO-Based Foveal Cone Metrics in Achromatopsia and Albinism Are Representative of Foveal Cone Structure

Retinal degeneration in BBS10 mice is ameliorated by subretinal gene replacement

Natural history study of visual function in patients with BBS1 and BBS10 -related Bardet-Biedl syndrome.

Towards an objective structural grading scheme of foveal hypoplasia in human albinism

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