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ARVO Annual Meeting Abstract June 2025

Recovery of Cone-Mediated Vision in a Severe Ciliopathy after Gene Augmentation: One Year Results of a Phase I/II Trial for LCA5 -LCA

Tomas S Aleman; Artur V Cideciyan; Katherine E. Uyhazi; Mariejel L Weber; Alejandro J. Roman; Malgorzata Swider; Alexander Sumaroka; Erin C O'Neil; Arlene J Santos; Katherine H Maguire; Elena M Aleman; Kelsey M Parchinski; Rebecca Kim; Makayla Fradin; Junwei Sun; Drew H Scoles; Vivian Wu; Alexandra Viviann Garafalo; Ashwath Jayagopal; Ben Yerxa; Sarah Tuller; Albert M Maguire; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):881.

ARVO Annual Meeting Abstract June 2025

Evaluation of ocular tolerability of OPGx-RDH12 by subretinal delivery in cynomolgus primates

Ashwath Jayagopal; Mayur Choudhary; Ben Yerxa; George Magrath

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1621.

ARVO Annual Meeting Abstract June 2024

AAV8- hLCA5 Subretinal Delivery to the Macula in LCA5 -associated Leber Congenital Amaurosis ( LCA5 -LCA): Preliminary Safety and Efficacy Results of an Ongoing Phase I/II Gene Therapy Trial

Tomas S Aleman; Artur V Cideciyan; Mariejel L Weber; Arlene Santos; Katherine E. Uyhazi; Kelsey Parchinski; William Chung; Paris Margaritis; junwei sun; Drew Scoles; Alexandra V Garafalo; Ashwath Jayagopal; Benjamin R Yerxa; Sarah Tuller; Albert Maguire; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3288.

ARVO Annual Meeting Abstract June 2024

Development of OPGx-BEST1 AAV gene therapy for the treatment of bestrophinopathies

Mayur Choudhary; Alexa Gray; Yu Sato; Jennifer Caroline Kwok; Vik Arora; Benjamin R Yerxa; Artur V Cideciyan; Gustavo D Aguirre; William A Beltran; Ashwath Jayagopal

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5335.

ARVO Annual Meeting Abstract June 2023

Evaluation of MERTK gene therapy constructs in cell culture models

Elisebeth Torretti; Scott Greenwald; Benjamin Yerxa; Ashwath Jayagopal; Mayur Choudhary

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3002.

ARVO Annual Meeting Abstract June 2021

Biophysical Characterization of Antibody Biopolymer Conjugate (ABC) Platform for Improved Therapy of Retinal Vascular Diseases

Fernando Correa; Carrie Su; Long Pham; Namrata Prasad; Chandrani Chakraborty; Janine Lu; Rachel Jacobson; Bernd Jandeleit; Didier Benoit; Xiaojian Huang; Ashwath Jayagopal; Hong Liang; Victor Perlroth

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):561.

ARVO Annual Meeting Abstract June 2020

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Haitao Liu; J. Samuel Zigler; Ashwath Jayagopal; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4157.

ARVO Annual Meeting Abstract July 2019

Engineering of locked nucleic acids with small molecule ligands for ocular surface diseases

Kilchrist V. Kilchrist; Ashwath Jayagopal; Faye Drawnel

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3372.

ARVO Annual Meeting Abstract July 2019

Early local activation of complement in aqueous humor of patients with age-related macular degeneration

Lebriz Altay; Tina Schick; Gabriella Widmer; Guillemette Duchateau-Nguyen; Paulo Piraino; Ashwath Jayagopal; Faye Drawnel; Sascha Fauser

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2973.

ARVO Annual Meeting Abstract July 2018

A potent LXR (liver X receptor) agonist can restore lysosome-mediated clearance in RPE cells from a mouse model with AMD-like phenotype

Debasish Sinha; Meysam Yazdankhah; Peng Shang; Cyrille Maugeais; Hasane Ratni; Stacey L Hose; Imran Ahmed Bhutto; Ashwath Jayagopal

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2448.

ARVO Annual Meeting Abstract July 2018

Rapid-aging Xpg -/- mice model age-related retinal inflammation

Faye M Drawnel; Olivia O'Leary; Tabea Grossenbacher; Laura Schwander; Carolin Willburger; William Riboulet; Wilbert Vermeij; Jan HJ Hoeijmakers; Richard H Foxton; Ashwath Jayagopal; Ulrich F O Luhmann

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3260.

Retina July 2017

In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO)

PDF

Md. Imam Uddin; Ashwath Jayagopal; Gary W. McCollum; Rong Yang; John S. Penn
TAGS: diagnostic imaging, hypoxia, mice, retinal vein occlusion, fluorescence, lasers
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3818-3824. https://doi.org/10.1167/iovs.16-21187

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2017

Pro-inflammatory phenotypes of retinal microvascular endothelial cells and monocytes upon RAGE Activation

Faye Drawnel; Derrick Feenstra; Kristin Sokoll; Gergö Sipos; Julia Hesselmann; Ashwath Jayagopal

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2531.

ARVO Annual Meeting Abstract June 2017

Sustained Intravitreal Delivery of Small and Large Molecules with Injectable Hydrogels

Mark Tibbitt; Andrew Auerbach; Ashwath Jayagopal; Robert Langer

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2971.

ARVO Annual Meeting Abstract June 2017

In Vivo Molecular Imaging of Retinal Hypoxia in a Mouse Model of Laser-induced Retinal Vein Occlusion (RVO)

Md Imam Uddin; Ashwath Jayagopal; Gary W. McCollum; John S Penn

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3665.

ARVO Annual Meeting Abstract June 2017

Real-time measurements of vascular permeability in the mouse eye using vitreous fluorophotometry

Richard Foxton; Ashwath Jayagopal; Nadine Colé

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2030.

ARVO Annual Meeting Abstract September 2016

VCAM-1 targeted in vivo imaging of neovascular disease in preclinical model

Md Imam Uddin; Stephanie Evans; Alexis Wong; David W. Wright; Ashwath Jayagopal; John S Penn

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1627.

ARVO Annual Meeting Abstract September 2016

Sustained Intravitreal Drug Delivery with Injectable Polymer-Nanoparticle Hydrogels

Mark W Tibbitt; Eric A Appel; Ashwath Jayagopal; Robert Langer

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3651.

ARVO Annual Meeting Abstract June 2015

Adipose stromal cells enriched for CD146+ display increased migration and adhesion and ameliorate retinal ischemia-reperfusion injury

Rajashekhar Gangaraju; Yogesh Jonna; Ahmed R Gomaa; Ashwath Jayagopal

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):921.

ARVO Annual Meeting Abstract June 2015

In Vivo Imaging of Retinal Hypoxia

Ashwath Jayagopal; Md Imam Uddin

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):31.

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Recovery of Cone-Mediated Vision in a Severe Ciliopathy after Gene Augmentation: One Year Results of a Phase I/II Trial for LCA5 -LCA

Evaluation of ocular tolerability of OPGx-RDH12 by subretinal delivery in cynomolgus primates

AAV8- hLCA5 Subretinal Delivery to the Macula in LCA5 -associated Leber Congenital Amaurosis ( LCA5 -LCA): Preliminary Safety and Efficacy Results of an Ongoing Phase I/II Gene Therapy Trial

Development of OPGx-BEST1 AAV gene therapy for the treatment of bestrophinopathies

Evaluation of MERTK gene therapy constructs in cell culture models

Biophysical Characterization of Antibody Biopolymer Conjugate (ABC) Platform for Improved Therapy of Retinal Vascular Diseases

Akt2 signaling in retinal pigment epithelial cells contributes to the development of diabetic retinopathy

Engineering of locked nucleic acids with small molecule ligands for ocular surface diseases

Early local activation of complement in aqueous humor of patients with age-related macular degeneration

A potent LXR (liver X receptor) agonist can restore lysosome-mediated clearance in RPE cells from a mouse model with AMD-like phenotype

Rapid-aging Xpg -/- mice model age-related retinal inflammation

In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO)

Pro-inflammatory phenotypes of retinal microvascular endothelial cells and monocytes upon RAGE Activation

Sustained Intravitreal Delivery of Small and Large Molecules with Injectable Hydrogels

In Vivo Molecular Imaging of Retinal Hypoxia in a Mouse Model of Laser-induced Retinal Vein Occlusion (RVO)

Real-time measurements of vascular permeability in the mouse eye using vitreous fluorophotometry

VCAM-1 targeted in vivo imaging of neovascular disease in preclinical model

Sustained Intravitreal Drug Delivery with Injectable Polymer-Nanoparticle Hydrogels

Adipose stromal cells enriched for CD146+ display increased migration and adhesion and ameliorate retinal ischemia-reperfusion injury

In Vivo Imaging of Retinal Hypoxia

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