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ARVO Annual Meeting Abstract June 2020

A novel epitope-tagged Clarin-1 knock-in mouse with retinal dysfunction and profound congenital deafness

Astra Dinculescu; Omar Akil; Susan Bolch; Frank M Dyka; William N Ruddick; Chiab Simpson; Lei Xu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2446. doi:

ARVO Annual Meeting Abstract July 2019

Functional Consequences and Cellular Distribution of C1QTNF5 Mutants in Murine Retinal Pigment Epithelium

Astra Dinculescu; Lei Xu; Susan N Bolch; Frank M Dyka; Ping Zhu; Hugh McDowell

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4899. doi:

ARVO Annual Meeting Abstract July 2018

Phenotypic consequences of amino acid substitutions at the S163 position in C1QTNF5 protein following expression in murine RPE

Astra Dinculescu; Susan Bolch; Frank M Dyka; Manoj Kulkarni; Chiab Simpson; W Clay Smith; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3052. doi:

ARVO Annual Meeting Abstract July 2018

The expression pattern and pathological effects of CLRN1 mutant proteins in the mouse retina

Susan Bolch; Frank M Dyka; Manoj Kulkarni; Rachel Stupay; Chiab Simpson; W Clay Smith; William W Hauswirth; Astra Dinculescu

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3053. doi:

ARVO Annual Meeting Abstract June 2017

RPE targeted overexpression of mutant S163R C1QTNF5 in various mouse models of RPE/photoreceptor dysfunction

Astra Dinculescu; Frank M Dyka; Seok-Hong Min; Rachel M Stupay; W. Clay Smith; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5229. doi:

ARVO Annual Meeting Abstract September 2016

Long-term preservation of retinal function in the rd6 mouse model of retinitis pigmentosa following AAV-mediated gene therapy

Rachel Michelle Stupay; Astra Dinculescu; Seok-Hong Min; Sanford L. Boye; Vince Chiodo Chiodo; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1167. doi:

ARVO Annual Meeting Abstract September 2016

Co-expression and interaction of wild-type and mutant C1QTNF5 in vivo : implications for gene-therapy

Astra Dinculescu; Frank M Dyka; Seok-Hong Min; Rachel Michelle Stupay; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1173. doi:

Retina October 2015

Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium

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Astra Dinculescu; Seok-Hong Min; Frank M. Dyka; Wen-Tao Deng; Rachel M. Stupay; Vince Chiodo; W. Clay Smith; William W. Hauswirth
TAGS: antibodies, eye, immunohistochemistry, injections, mice, photoreceptors, proteins, retinal pigment epithelium, spatial vectors, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2015; 56(11):6971-6980. doi: https://doi.org/10.1167/iovs.15-17166

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Localization of Clarin-1 in Photoreceptor Cells and Optimized AAV Gene Delivery of Clarin-1 to the Mouse Retina

William W Hauswirth; Rachel M Stupay; Ping Zhu; Wen-Tao Deng; Vince Chiodo; Sanford L Boye; Qiuhong Li; Astra Dinculescu

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3630. doi:

ARVO Annual Meeting Abstract June 2015

Clarin-1 expression in the inner retina: implications for gene therapy

Astra Dinculescu; Rachel M Stupay; Seok-Hong Min; Sanford L Boye; Vince Chiodo; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3632. doi:

ARVO Annual Meeting Abstract April 2014

Over-expression of human mutant C1QTNF5 (Ser163Arg) in RPE cells leads to both RPE and photoreceptor cell loss in wild-type mice

Astra Dinculescu; Seok-Hong Min; Frank M Dyka; Renee C Ryals; Vince Chiodo; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2188. doi:

ARVO Annual Meeting Abstract April 2014

Optimization of Clarin-1 AAV Gene Delivery Vectors to the Mouse Retina

Rachel M Stupay; Ping Zhu; Wen-tao Deng; Vince Chiodo; Sanford L Boye; Qiuhong Li; William W Hauswirth; Astra Dinculescu

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3324. doi:

ARVO Annual Meeting Abstract April 2014

Heparan sulfate affinity dictates transduction of photoreceptors from the vitreous by capsid mutated AAV2 variants.

Sanford L Boye; Antonette Bennett; Kim VanVliet; Astra Dinculescu; Miranda L White; James Peterson; Mavis Agbandje-McKenna; Shannon Boye

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3337. doi:

ARVO Annual Meeting Abstract June 2013

A retinal phenotype in Usher IIIA mouse models

Rachel Stupay; W Clay Smith; Wen-Tao Deng; Ping Zhu; William Hauswirth; Astra Dinculescu

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):298. doi:

ARVO Annual Meeting Abstract June 2013

CTRP5 over-expression in RPE cells leads to loss of RPE cell adhesion and retinal degeneration in wild-type mice

Astra Dinculescu; Seok-Hong Min; Wen-Tao Deng; Jie Li; Renee Ryals; Rachel Stupay; Ping Zhu; Bhubanananda Sahu; Radha Ayyagari; William Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):4594. doi:

Retina April 2012

Tyrosine-Mutant AAV8 Delivery of Human MERTK Provides Long-Term Retinal Preservation in RCS Rats

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Wen-Tao Deng; Astra Dinculescu; Qiuhong Li; Sanford L. Boye; Jie Li; Marina S. Gorbatyuk; Jijing Pang; Vince A. Chiodo; Michael T. Matthes; Douglas Yasumura; Li Liu; Fowzan S. Alkuraya; Kang Zhang; Douglas Vollrath; Matthew M. LaVail; William W. Hauswirth
TAGS: eye, mertk gene, rats, tyrosine, retina, photoreceptors, spatial vectors, did not receive therapy or drug
Invest. Ophthalmol. Vis. Sci.. 2012; 53(4):1895-1904. doi: https://doi.org/10.1167/iovs.11-8831

Includes: Supplemental Content

ARVO Annual Meeting Abstract March 2012

A Self-complementary Y733F Capsid Mutant of AAV8 Prevents Photoreceptor Degeneration and Restores Retinal Function in the Rd6 Mouse Model of Retinitis Pigmentosa

Astra Dinculescu; Qiuhong Li; Wen-Tao Deng; Seok-Hong Min; Jianwen Liu; Issam McDoom; William W. Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1634. doi:

ARVO Annual Meeting Abstract March 2012

Evaluation Of Rod Photoreceptor Function And Preservation Following Retinal Gene Therapy In The PDE6A Mutant Dog

Freya M. Mowat; Joshua T. Bartoe; Ashlee Bruewer; Astra Dinculescu; Sanford L. Boye; William W. Hauswirth; Simon M. Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1928. doi:

ARVO Annual Meeting Abstract April 2011

Clarin-1 Expression In The Retina Using AAV Mediated Gene Delivery

Astra Dinculescu; Yoshikazu Imanishi; Frank M. Dyka; Jianwen Liu; Issam McDoom; Xuan Liu; Hanna Västinsalo; Reetta Jalkanen; Eeva-Marja Sankila; William W. Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3336. doi:

ARVO Annual Meeting Abstract April 2011

AAV Vectors With Engineered Capsid Mutations Efficiently Transduce Outer Retina With Intravitreal Delivery And Result In Rapid Gene Expression With Subretinal Delivery In Dogs

Joshua T. Bartoe; Freya Mowat; Astra Dinculescu; Sanford Boye; William Hauswirth; Simon Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1420. doi:

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A novel epitope-tagged Clarin-1 knock-in mouse with retinal dysfunction and profound congenital deafness

Functional Consequences and Cellular Distribution of C1QTNF5 Mutants in Murine Retinal Pigment Epithelium

Phenotypic consequences of amino acid substitutions at the S163 position in C1QTNF5 protein following expression in murine RPE

The expression pattern and pathological effects of CLRN1 mutant proteins in the mouse retina

RPE targeted overexpression of mutant S163R C1QTNF5 in various mouse models of RPE/photoreceptor dysfunction

Long-term preservation of retinal function in the rd6 mouse model of retinitis pigmentosa following AAV-mediated gene therapy

Co-expression and interaction of wild-type and mutant C1QTNF5 in vivo : implications for gene-therapy

Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium

Localization of Clarin-1 in Photoreceptor Cells and Optimized AAV Gene Delivery of Clarin-1 to the Mouse Retina

Clarin-1 expression in the inner retina: implications for gene therapy

Over-expression of human mutant C1QTNF5 (Ser163Arg) in RPE cells leads to both RPE and photoreceptor cell loss in wild-type mice

Optimization of Clarin-1 AAV Gene Delivery Vectors to the Mouse Retina

Heparan sulfate affinity dictates transduction of photoreceptors from the vitreous by capsid mutated AAV2 variants.

A retinal phenotype in Usher IIIA mouse models

CTRP5 over-expression in RPE cells leads to loss of RPE cell adhesion and retinal degeneration in wild-type mice

Tyrosine-Mutant AAV8 Delivery of Human MERTK Provides Long-Term Retinal Preservation in RCS Rats

A Self-complementary Y733F Capsid Mutant of AAV8 Prevents Photoreceptor Degeneration and Restores Retinal Function in the Rd6 Mouse Model of Retinitis Pigmentosa

Evaluation Of Rod Photoreceptor Function And Preservation Following Retinal Gene Therapy In The PDE6A Mutant Dog

Clarin-1 Expression In The Retina Using AAV Mediated Gene Delivery

AAV Vectors With Engineered Capsid Mutations Efficiently Transduce Outer Retina With Intravitreal Delivery And Result In Rapid Gene Expression With Subretinal Delivery In Dogs

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