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Clinical and Epidemiologic Research April 2019

Retinal Layer Thicknesses in Early Age-Related Macular Degeneration: Results From the German AugUR Study

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Caroline Brandl; Christiane Brücklmayer; Felix Günther; Martina E. Zimmermann; Helmut Küchenhoff; Horst Helbig; Bernhard H. F. Weber; Iris M. Heid; Klaus J. Stark
TAGS: sample size, biological response modifiers, color, photoreceptors, reference values, software, diagnostic imaging, eye, age-related macular degeneration, reliability, german, spectral-domain optical coherence tomography, surveys
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1581-1594. doi: 10.1167/iovs.18-25332

Includes: Supplemental Content

Special Issue August 2018

Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study

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Philipp L. Müller; Maximilian Pfau; Philipp T. Möller; Jennifer Nadal; Matthias Schmid; Moritz Lindner; Luis de Sisternes; Heidi Stöhr; Bernhard H. F. Weber; Christine Neuhaus; Philipp Herrmann; Steffen Schmitz-Valckenberg; Frank G. Holz; Monika Fleckenstein
TAGS: angiogram, atrophy, age-related macular degeneration, stargardt's disease, chief complaint, fluid flow
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD122-AMD131. doi: 10.1167/iovs.18-23819

Includes: Supplemental Content

Genetics January 2017

Mutation Spectrum of the ABCA4 Gene in 335 Stargardt Disease Patients From a Multicenter German Cohort—Impact of Selected Deep Intronic Variants and Common SNPs

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Heidi L. Schulz; Felix Grassmann; Ulrich Kellner; Georg Spital; Klaus Rüther; Herbert Jägle; Karsten Hufendiek; Philipp Rating; Cord Huchzermeyer; Maria J. Baier; Bernhard H. F. Weber; Heidi Stöhr

Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):394-403. doi: 10.1167/iovs.16-19936

Includes: Supplemental Content

Retina October 2016

Progression of Late-Onset Stargardt Disease

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Stanley Lambertus; Moritz Lindner; Nathalie M. Bax; Matthias M. Mauschitz; Jennifer Nadal; Matthias Schmid; Steffen Schmitz-Valckenberg; Anneke I. den Hollander; Bernhard H. F. Weber; Frank G. Holz; Gert Jan van der Wilt; Monika Fleckenstein; Carel B. Hoyng; for the Foveal sparing Atrophy Study Team (FAST)
TAGS: sample size, atrophy, cohort studies, visual acuity, diagnostic imaging, eye, stargardt's disease, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5186-5191. doi: 10.1167/iovs.16-19833

Includes: Supplemental Content

Clinical and Epidemiologic Research May 2016

Distinct Genetic Risk Profile of the Rapidly Progressing Diffuse-Trickling Subtype of Geographic Atrophy in Age-Related Macular Degeneration (AMD)

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Monika Fleckenstein; Felix Grassmann; Moritz Lindner; Maximilian Pfau; Joanna Czauderna; Tobias Strunz; Claudia von Strachwitz; Steffen Schmitz-Valckenberg; Frank G. Holz; Bernhard H. F. Weber
TAGS: phenotype, atrophy, genes, age-related macular degeneration, genetic risk
Invest. Ophthalmol. Vis. Sci.. 2016; 57(6):2463-2471. doi: 10.1167/iovs.15-18593

Includes: Supplemental Content

Retina December 2015

Monoallelic ABCA4 Mutations Appear Insufficient to Cause Retinopathy: A Quantitative Autofluorescence Study

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Philipp L. Müller; Martin Gliem; Elisabeth Mangold; Hanno J. Bolz; Robert P. Finger; Myra McGuinness; Christian Betz; Zhichun Jiang; Bernhard H. F. Weber; Robert E. MacLaren; Frank G. Holz; Roxana A. Radu; Peter Charbel Issa
TAGS: phenotype, mutation, retinal diseases, mice, autofluorescence
Invest. Ophthalmol. Vis. Sci.. 2015; 56(13):8179-8186. doi: 10.1167/iovs.15-17629

Includes: Supplemental Content

Glaucoma December 2015

Migraine and Vasospasm in Glaucoma: Age-Related Evaluation of 2027 Patients With Glaucoma or Ocular Hypertension

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Gwendolyn Gramer; Bernhard H. F. Weber; Eugen Gramer
TAGS: vascular constriction, migraine disorders, glaucoma
Invest. Ophthalmol. Vis. Sci.. 2015; 56(13):7999-8007. doi: 10.1167/iovs.15-17274

Retina April 2015

Sorsby Fundus Dystrophy: Novel Mutations, Novel Phenotypic Characteristics, and Treatment Outcomes

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Martin Gliem; Philipp L. Müller; Elisabeth Mangold; Frank G. Holz; Hanno J. Bolz; Heidi Stöhr; Bernhard H. F. Weber; Peter Charbel Issa
TAGS: phenotype, mutation, drusen, atrophy, choroidal neovascularization, family, treatment outcome
Invest. Ophthalmol. Vis. Sci.. 2015; 56(4):2664-2676. doi: 10.1167/iovs.14-15733

Includes: Supplemental Content

Glaucoma January 2014

Results of a Patient-Directed Survey on Frequency of Family History of Glaucoma in 2170 Patients

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Gwendolyn Gramer; Bernhard H. F. Weber; Eugen Gramer
TAGS: glaucoma, open-angle glaucoma, family history
Invest. Ophthalmol. Vis. Sci.. 2014; 55(1):259-264. doi: 10.1167/iovs.13-13020

Biochemistry and Molecular Biology April 2012

A Subgroup of Age-Related Macular Degeneration is Associated With Mono-Allelic Sequence Variants in the ABCA4 Gene

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Lars G. Fritsche; Monika Fleckenstein; Britta S. Fiebig; Steffen Schmitz-Valckenberg; Almut Bindewald-Wittich; Claudia N. Keilhauer; Agnes B. Renner; Friederike Mackensen; Andreas Mößner; Daniel Pauleikhoff; Christine Adrion; Ulrich Mansmann; Hendrik P. N. Scholl; Frank G. Holz; Bernhard H. F. Weber
TAGS: alleles, phenotype, atrophy, genes, age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2012; 53(4):2112-2118. doi: 10.1167/iovs.11-8785

Includes: Supplemental Content

ARVO Annual Meeting Abstract March 2012

In Vivo Analysis Reveals Novel Aspects of Retinal Disease Progression in Rsh1-/Y Mice but no Therapeutic Effect of Carbonic Anhydrase Inhibition

Ahmad Zhour; Christian Grimm; Marijana Samardzija; Tobias Peters; Torsten Strasser; Sylvia Bolz; Bernhard H. F. Weber; Eberhart Zrenner; M. Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1134. doi:

Clinical Trials November 2011

Central Areolar Choroidal Dystrophy (CACD) and Age-Related Macular Degeneration (AMD): Differentiating Characteristics in Multimodal Imaging

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Dženita Smailhodzic; Monika Fleckenstein; Thomas Theelen; Camiel J. F. Boon; Ramon A. C. van Huet; Johannes P. H. van de Ven; Anneke I. Den Hollander; Steffen Schmitz-Valckenberg; Carel B. Hoyng; Bernhard H. F. Weber; Frank G. Holz; B. Jeroen Klevering
TAGS: drusen, atrophy, color, diagnostic imaging, eye, age-related macular degeneration, atrophic condition of skin, fundus photography, fundus autofluorescence imaging
Invest. Ophthalmol. Vis. Sci.. 2011; 52(12):8908-8918. doi: 10.1167/iovs.11-7926

Glaucoma January 2010

Heterozygous Loss-of-Function Variants in CYP1B1 Predispose to Primary Open-Angle Glaucoma

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Francesca Pasutto; Gabriela Chavarria-Soley; Christian Y. Mardin; Karin Michels-Rautenstrauss; Magnus Ingelman-Sundberg; Lorena Fernández-Martínez; Bernhard H. F. Weber; Bernd Rautenstrauss; André Reis
TAGS: mutation, open-angle glaucoma, heterozygote
Invest. Ophthalmol. Vis. Sci.. 2010; 51(1):249-254. doi: 10.1167/iovs.09-3880

Glaucoma June 2009

Exploring Functional Candidate Genes for Genetic Association in German Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

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Mandy Krumbiegel; Francesca Pasutto; Christian Y. Mardin; Nicole Weisschuh; Daniela Paoli; Eugen Gramer; Matthias Zenkel; Bernhard H. F. Weber; Friedrich E. Kruse; Ursula Schlötzer-Schrehardt; André Reis
TAGS: alleles, glaucoma, cohort studies, exfoliation syndrome, haplotypes, single nucleotide polymorphism, syndrome, genetics, candidate disease gene, clu gene, german
Invest. Ophthalmol. Vis. Sci.. 2009; 50(6):2796-2801. doi: 10.1167/iovs.08-2339

Anatomy and Pathology/Oncology July 2008

Abnormal Vessel Formation in the Choroid of Mice Lacking Tissue Inhibitor of Metalloprotease-3

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Andreas Janssen; Julia Hoellenriegel; Marton Fogarasi; Heinrich Schrewe; Mathias Seeliger; Ernst Tamm; Andreas Ohlmann; Christian Albrecht May; Bernhard H. F. Weber; Heidi Stöhr
TAGS: metalloproteases, body tissue, choroid, mice
Invest. Ophthalmol. Vis. Sci.. 2008; 49(7):2812-2822. doi: 10.1167/iovs.07-1444

Glaucoma April 2008

Association of LOXL1 Common Sequence Variants in German and Italian Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

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Francesca Pasutto; Mandy Krumbiegel; Christian Y. Mardin; Daniela Paoli; Robert Lämmer; Bernhard H. F. Weber; Friedrich E. Kruse; Ursula Schlötzer-Schrehardt; André Reis
TAGS: exfoliation syndrome, single nucleotide polymorphism, german, italian
Invest. Ophthalmol. Vis. Sci.. 2008; 49(4):1459-1463. doi: 10.1167/iovs.07-1449

Glaucoma January 2008

Profiling of WDR36 Missense Variants in German Patients with Glaucoma

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Francesca Pasutto; Christian Y. Mardin; Karin Michels-Rautenstrauss; Bernhard H. F. Weber; Heinrich Sticht; Gabriela Chavarria-Soley; Bernd Rautenstrauss; Friedrich Kruse; André Reis
TAGS: mutation, glaucoma, wdr36 gene, german
Invest. Ophthalmol. Vis. Sci.. 2008; 49(1):270-274. doi: 10.1167/iovs.07-0500

Retinal Cell Biology February 2007

Genome-Wide Expression Profiling of the Retinoschisin-Deficient Retina in Early Postnatal Mouse Development

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Andrea Gehrig; Thomas Langmann; Franziska Horling; Andreas Janssen; Michael Bonin; Michael Walter; Sven Poths; Bernhard H. F. Weber
TAGS: apoptosis, polymerase chain reaction, gene expression profiling, genes, genome, microglia, mice, proteins, retina, egr1 gene, molecular profiling
Invest. Ophthalmol. Vis. Sci.. 2007; 48(2):891-900. doi: 10.1167/iovs.06-0641

Includes: Supplemental Content

Biochemistry and Molecular Biology December 2003

Cellular Localization of the MPP4 Protein in the Mammalian Retina

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Heidi Stöhr; Jelena Stojic; Bernhard H. F. Weber
TAGS: cattle, retinal cone, dna, complementary, fluorescent antibody technique, mammals, tissue membrane, suidae, antibodies, proteins, retina
Invest. Ophthalmol. Vis. Sci.. 2003; 44(12):5067-5074. doi: 10.1167/iovs.03-0702

Retina August 2002

A Mouse Model for Sorsby Fundus Dystrophy

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Bernhard H. F. Weber; Biaoyang Lin; Karen White; Konrad Kohler; Galina Soboleva; Sabine Herterich; Mathias W. Seeliger; Gesine B. Jaissle; Christian Grimm; Charlotte Reme; Andreas Wenzel; Esther Asan; Heinrich Schrewe
TAGS: mutation, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2002; 43(8):2732-2740. doi:

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Retinal Layer Thicknesses in Early Age-Related Macular Degeneration: Results From the German AugUR Study

Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study

Mutation Spectrum of the ABCA4 Gene in 335 Stargardt Disease Patients From a Multicenter German Cohort—Impact of Selected Deep Intronic Variants and Common SNPs

Progression of Late-Onset Stargardt Disease

Distinct Genetic Risk Profile of the Rapidly Progressing Diffuse-Trickling Subtype of Geographic Atrophy in Age-Related Macular Degeneration (AMD)

Monoallelic ABCA4 Mutations Appear Insufficient to Cause Retinopathy: A Quantitative Autofluorescence Study

Migraine and Vasospasm in Glaucoma: Age-Related Evaluation of 2027 Patients With Glaucoma or Ocular Hypertension

Sorsby Fundus Dystrophy: Novel Mutations, Novel Phenotypic Characteristics, and Treatment Outcomes

Results of a Patient-Directed Survey on Frequency of Family History of Glaucoma in 2170 Patients

A Subgroup of Age-Related Macular Degeneration is Associated With Mono-Allelic Sequence Variants in the ABCA4 Gene

In Vivo Analysis Reveals Novel Aspects of Retinal Disease Progression in Rsh1-/Y Mice but no Therapeutic Effect of Carbonic Anhydrase Inhibition

Central Areolar Choroidal Dystrophy (CACD) and Age-Related Macular Degeneration (AMD): Differentiating Characteristics in Multimodal Imaging

Heterozygous Loss-of-Function Variants in CYP1B1 Predispose to Primary Open-Angle Glaucoma

Exploring Functional Candidate Genes for Genetic Association in German Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Abnormal Vessel Formation in the Choroid of Mice Lacking Tissue Inhibitor of Metalloprotease-3

Association of LOXL1 Common Sequence Variants in German and Italian Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Profiling of WDR36 Missense Variants in German Patients with Glaucoma

Genome-Wide Expression Profiling of the Retinoschisin-Deficient Retina in Early Postnatal Mouse Development

Cellular Localization of the MPP4 Protein in the Mammalian Retina

A Mouse Model for Sorsby Fundus Dystrophy

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