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ARVO Annual Meeting Abstract June 2024

Metformin promotes Prdx6 transcription By Enriching Bmal1-Nrf2 heterodimers at E-Box and ARE Sequences And Provides Cytoprotection

Dhirendra P Singh; Eri Kubo; Ronald R Krueger; Bhavana Chhunchha

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3233.

ARVO Annual Meeting Abstract June 2024

Prdx6 Impedes Lens Epithelial Cell From Klf9/Nlrp3 Inflammasome Activation-Driven Pyroptotic Cell Death In Aging/Oxidative Stress

Bhavana Chhunchha; Eri Kubo; Ronald R Krueger; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3223.

ARVO Annual Meeting Abstract June 2023

Metformin-activated AMPK boosts the Nrf2/Prdx6 signaling axis and cytoprotection via negative regulation of Bach1

Dhirendra P Singh; Bhavana Chhunchha; Dhavalkumar Shukal; Ronald R Krueger; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1222.

ARVO Annual Meeting Abstract June 2023

Klf9 amplifies Nlrp3 inflammasome-mediated inflammatory death signaling in lens epithelial cells via transactivation of Nlrp3 gene

Bhavana Chhunchha; Eri Kubo; Kumar Rakesh; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4144.

ARVO Annual Meeting Abstract June 2022

Topical instillation of Metformin Prevents Oxidative Stress-Induced Eye Lens Opacity Through Induction of AMPK-Nrf2-Mediated Antioxidant Pathway

Dhirendra P Singh; Bhavana Chhunchha; Ronald R krueger; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):18.

ARVO Annual Meeting Abstract June 2022

Lens epithelial cell Prdx6 deficiency activates ROS-Inflammasome pathway-driven cell death

Bhavana Chhunchha; Eri Kubo; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):663 – F0018.

ARVO Annual Meeting Abstract June 2021

Prdx6-Loaded PLGA Nanoparticles Protect Lens Epithelial Cells From Oxidative Stress And Prevent Lens Opacity

Bhavana Chhunchha; Eri Kubo; Prerna Singh; Uday B Kompella; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2088.

ARVO Annual Meeting Abstract June 2021

Topical Application of Hydralazine Induces Resistance Against Oxidative Stress In Eye Lenses By Activating Nrf2-mediated Antioxidant Response Genes

Dhirendra P Singh; Bhavana Chhunchha; Hiroshi Sasaki; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2068.

ARVO Annual Meeting Abstract July 2019

Metformin Restores Impaired Antioxidant Defense Response In Aging Lens Epithelial Cells By Reactivating Nrf2/ARE/Prdx6 Axis

Bhavana Chhunchha; Eri Kubo; Sanjay P Singh; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1112.

ARVO Annual Meeting Abstract July 2019

Core Clock Protein Bmal 1 Controls Reactive Oxygen Species Homeostasis And Oxidative Responses By Transregulating Prdx6 Expression

Dhirendra P Singh; Eri Kubo; Bhavana Chhunchha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1127.

ARVO Annual Meeting Abstract July 2018

Prdx6 Delivery Increases Lens Epithelial Cell Survival during Oxidative Stress by Reactivating Sp1-Prdx6 Transcription

Bhavana Chhunchha; Eri Kubo; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3041.

ARVO Annual Meeting Abstract July 2018

Ginkgolic Acid Inhibits Aberrant Sumoylation-Mediated Dysregulation of Prdx6 and Sp1 to Protect Lens Epithelial Cells against Oxidative Injury

Dhirendra P Singh; Bhavana Chhunchha; gunho won; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5652.

ARVO Annual Meeting Abstract June 2017

Switching Of Redox Signaling By Sulforaphane Determines Lens Epithelial Cells Fate By Hormetic Mechanisms Involving Prdx6/Nrf2 and Klf9 Pathways

Bhavana Chhunchha; Eri Kubo; Hiroshi Sasaki; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3174.

ARVO Annual Meeting Abstract June 2017

Stabilization Of Prdx6 Activity By Targeted Mutation Of Sumoylation Sites Protects Trabecular Meshwork Cells From Oxidative Damage

Dhirendra P Singh; Bhavana Chhunchha; Prerna Singh; W Daniel Stamer; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4908.

ARVO Annual Meeting Abstract September 2016

Sumoylation Motif Disruption Of Prdx6 (K122/142R) Enhances Protection Against Oxidative Stress In Lens Epithelial Cells By Potentiating GSH Peroxidase And aiPLA 2 Activities

Dhirendra P Singh; Bhavana Chhunchha; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2027.

ARVO Annual Meeting Abstract September 2016

Sumoylation At K16 Of Specificity Protein 1 Represses Prdx6 Transcription Leading To Lens Epithelial Cell Death During Oxidative Stress And Aging

Bhavana Chhunchha; Eri Kubo; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2030.

ARVO Annual Meeting Abstract June 2015

Nrf2 Accelerates Oxidative Stress And Lens Epithelial Cell Death Through Induction of KLF9-Driven Repression of Prdx6 In Response To Excessive Oxidative Load

Bhavana Chhunchha; Eri Kubo; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5601.

ARVO Annual Meeting Abstract June 2015

Replicative Senescence of Trabecular Meshwork Cells Is Associated With Loss Of Prdx6 By Sumoylation

Dhirendra P Singh; Nigar Fatma; Bhavana Chhunchha; W Daniel Stamer; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3678.

ARVO Annual Meeting Abstract April 2014

Prdx6 with Disrupted Sumoylation Sites, K122/142R Gains Function in Protecting Lens Epithelial Cells and Lenses by Abrogating Oxidative Stress-Induced Aberrant Sumoylation Signaling

Dhirendra P Singh; Bhavana Chhunchha; Eri Kubo

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3569.

ARVO Annual Meeting Abstract April 2014

Aging and Oxidative Stress-Induced Dysregulation of LEDGF Gene in Lens Epithelial Cells and Lenses Released by Sulforaphane Through Epigenetic Reprograming

Bhavana Chhunchha; Eri Kubo; Dhirendra P Singh

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):738.

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