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Retinal Cell Biology December 2018

Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration

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Wenyi Tang; Jun Ma; Ruiping Gu; Boya Lei; Xinyi Ding; Gezhi Xu
TAGS: apoptosis, polymerase chain reaction, in situ nick-end labeling, photoreceptors, retinal degeneration, retina, lipocalin-2 protein, light exposure, protein overexpression, reactive oxygen species, lentivirus, electroretinography, mitochondria, western blotting, signal transduction, lcn2 gene
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6014-6025. doi: 10.1167/iovs.18-25213

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

The effects of exogenous and endogenous liver X receptor agonists on LPS-induced inflammation in human retinal pigment epithelium cells

Peng Yu; Yiguo Qiu; Lin Yang; Yuxin Mai; Bo Lei

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5323. doi:

ARVO Annual Meeting Abstract July 2018

Attenuation of Intraocular Inflammatory Responses in Experimental Autoimmune Uveitis by TMP Is Associated with Modulating of the STAT3 and STAT4 Pathways

Bo Lei; Ru Lin

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5328. doi:

Retina July 2017

Glucocorticoid-Induced Leucine Zipper Protects the Retina From Light-Induced Retinal Degeneration by Inducing Bcl-xL in Rats

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Ruiping Gu; Wenyi Tang; Boya Lei; Xinyi Ding; Cheng Jiang; Gezhi Xu
TAGS: apoptosis, glucocorticoids, electroretinography, leucine zippers, retinal degeneration, wounds and injuries, rats, retina, bcl-xl protein, protein overexpression, exposure to light, opportunity for error
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3656-3668. doi: 10.1167/iovs.17-22116

Includes: Supplemental Content

Retinal Cell Biology June 2017

Overexpression of Angiotensin-Converting Enzyme 2 Ameliorates Amyloid β-Induced Inflammatory Response in Human Primary Retinal Pigment Epithelium

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Xinyu Fu; Ru Lin; Yiguo Qiu; Peng Yu; Bo Lei
TAGS: amyloid, apoptosis, cytokine, polymerase chain reaction, enzyme-linked immunosorbent assay, angiotensin-converting enzyme, inflammation, plasmids, monocyte chemoattractant protein-1, rna, messenger, proteins, antagonists, inflammatory response, protein overexpression, retinal pigment epithelium, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3018-3028. doi: 10.1167/iovs.17-21546

Physiology and Pharmacology January 2017

Glucocorticoid-Induced Leucine Zipper Suppresses ICAM-1 and MCP-1 Expression by Dephosphorylation of NF-κB p65 in Retinal Endothelial Cells

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Ruiping Gu; Boya Lei; Chen Jiang; Gezhi Xu
TAGS: endothelial cells, glucocorticoids, intercellular adhesion molecule 1, leucine zippers, monocyte chemoattractant protein-1, protein overexpression, opportunity for error
Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):631-641. doi: 10.1167/iovs.16-20933

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Amelioration of Amyloid β induced retinal inflammatory responses by a LXR agonist TO901317 is associated with inactivation of the NF-κB signaling and NLRP3 Inflammasome

Bo Lei; Chunyan Lei

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract June 2015

Activation of Liver X Receptor Protects Inner Retinal Damage Induced by N-methyl-D-aspartate

Bo Lei; Shijie Zheng

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3624. doi:

ARVO Annual Meeting Abstract June 2015

Downregulating p22phox ameliorates inflammation in Angiotensin II induced oxidative stress by regulating MAPK and NF-κB pathways in ARPE-19 cells

Yiguo Qiu; Lifei Tao; Peizeng Yang; Qiuhong Li; Bo Lei

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):839. doi:

Retina February 2015

Activation of Liver X Receptor Protects Inner Retinal Damage Induced by N-methyl-D-aspartate

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Shijie Zheng; Hongxia Yang; Zihe Chen; Changwei Zheng; Chunyan Lei; Bo Lei
TAGS: n-methylaspartate, liver x receptors
Invest. Ophthalmol. Vis. Sci.. 2015; 56(2):1168-1180. doi: 10.1167/iovs.14-15612

Retina June 2014

Angiotensin-Converting Enzyme 2 (ACE2) Activator Diminazene Aceturate Ameliorates Endotoxin-Induced Uveitis in Mice

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Yiguo Qiu; Pollob Kumar Shil; Ping Zhu; Hongxia Yang; Amrisha Verma; Bo Lei; Qiuhong Li
TAGS: cytokine, endotoxins, inflammatory cell, angiotensin-converting enzyme, inflammation, anterior chamber of eye, diminazene, uveitis, vitreous body, eye, mice, transcriptional activation, normal saline, saline solution, eye inflammation
Invest. Ophthalmol. Vis. Sci.. 2014; 55(6):3809-3818. doi: 10.1167/iovs.14-13883

Immunology and Microbiology April 2014

Activation of Liver X Receptor Alleviates Ocular Inflammation in Experimental Autoimmune Uveitis

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Hongxia Yang; Shijie Zheng; Yiguo Qiu; Yan Yang; Chaokui Wang; Peizeng Yang; Qiuhong Li; Bo Lei
TAGS: cytokine, autoimmune diseases, autoimmunity, interleukin-17, lymphocyte, peptides, uveitis, mice, retina, prevention, liver x receptors, eye inflammation
Invest. Ophthalmol. Vis. Sci.. 2014; 55(4):2795-2804. doi: 10.1167/iovs.13-13323

Immunology and Microbiology November 2013

MIF Gene Polymorphisms Confer Susceptibility to Vogt-Koyanagi-Harada Syndrome in a Han Chinese Population

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Chunxia Zhang; Shouli Liu; Shengping Hou; Bo Lei; Xiuyun Zheng; Xiang Xiao; Aize Kijlstra; Peizeng Yang
TAGS: polymorphism, disease susceptibility, genes, uveomeningoencephalitic syndrome, chinese people, chinese (other dialects)
Invest. Ophthalmol. Vis. Sci.. 2013; 54(12):7734-7738. doi: 10.1167/iovs.13-12187

ARVO Annual Meeting Abstract June 2013

Exogenous zinc ions interrupt visual signal transmission from photoreceptors to bipolar cells and reduce retinal TRPM1 expression in mouse

Bo Lei; Yu Liu; Tao Lin; Hongxia Yang

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2672. doi:

ARVO Annual Meeting Abstract June 2013

Angiotensin-Converting Enzyme 2 (ACE2) Activator DIZE Ameliorates Endotoxin-Induced Uveitis in Mice

Yiguo Qiu; Pollob Shil; Ping Zhu; Hongxia Yang; Bo Lei; Qiuhong Li

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2930. doi:

Immunology and Microbiology July 2012

Decreased IL-27 Expression in Association with an Increased Th17 Response in Vogt-Koyanagi-Harada Disease

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Chaokui Wang; Yuan Tian; Bo Lei; Xiang Xiao; Zi Ye; Fuzhen Li; Aize Kijlstra; Peizeng Yang
TAGS: enzyme-linked immunosorbent assay, interleukin-17, uveomeningoencephalitic syndrome, interleukin-27
Invest. Ophthalmol. Vis. Sci.. 2012; 53(8):4668-4675. doi: 10.1167/iovs.12-9863

Includes: Supplemental Content

ARVO Annual Meeting Abstract March 2012

The Characteristics Of Cone-driven Oscillatory Potentials In Human Electroretinogram

Bo Lei; Hui Peng; Juanping Yin; Qiuhong Li

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5703. doi:

ARVO Annual Meeting Abstract April 2011

Electroretinogram and Fundus Changes in the Progress of Choroidal Osteoma

Bo Lei; Ni Zhang; Hui Peng; Qiuhong Li

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3504. doi:

ARVO Annual Meeting Abstract April 2011

Hyperglycemia Induced Methylation Changes In Genes Of Ocular Renin Angiotensin System

Amrisha Verma; Zhiying Shan; Bo Lei; Xuan Liu; Takahiko Nakagawa; Maria B. Grant; William W. Hauswirth; Xun Xu; Mohan K. Raizada; Qiuhong Li

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5952. doi:

ARVO Annual Meeting Abstract April 2011

CD4+ T Cells In Vogt-koyanagi-harada Disease Show A Decreased Stimulation Of IL-27 Expression By Dendritic Cells

Peizeng Yang; Chaokui Wang; Lichun Tian; Ju Shao; Fuzhen Li; Yuan Tian; Lei Bo; Shengping Hou; Kijlstra Aize

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):6638. doi:

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Light-Induced Lipocalin 2 Facilitates Cellular Apoptosis by Positively Regulating Reactive Oxygen Species/Bim Signaling in Retinal Degeneration

The effects of exogenous and endogenous liver X receptor agonists on LPS-induced inflammation in human retinal pigment epithelium cells

Attenuation of Intraocular Inflammatory Responses in Experimental Autoimmune Uveitis by TMP Is Associated with Modulating of the STAT3 and STAT4 Pathways

Glucocorticoid-Induced Leucine Zipper Protects the Retina From Light-Induced Retinal Degeneration by Inducing Bcl-xL in Rats

Overexpression of Angiotensin-Converting Enzyme 2 Ameliorates Amyloid β-Induced Inflammatory Response in Human Primary Retinal Pigment Epithelium

Glucocorticoid-Induced Leucine Zipper Suppresses ICAM-1 and MCP-1 Expression by Dephosphorylation of NF-κB p65 in Retinal Endothelial Cells

Amelioration of Amyloid β induced retinal inflammatory responses by a LXR agonist TO901317 is associated with inactivation of the NF-κB signaling and NLRP3 Inflammasome

Activation of Liver X Receptor Protects Inner Retinal Damage Induced by N-methyl-D-aspartate

Downregulating p22phox ameliorates inflammation in Angiotensin II induced oxidative stress by regulating MAPK and NF-κB pathways in ARPE-19 cells

Activation of Liver X Receptor Protects Inner Retinal Damage Induced by N-methyl-D-aspartate

Angiotensin-Converting Enzyme 2 (ACE2) Activator Diminazene Aceturate Ameliorates Endotoxin-Induced Uveitis in Mice

Activation of Liver X Receptor Alleviates Ocular Inflammation in Experimental Autoimmune Uveitis

MIF Gene Polymorphisms Confer Susceptibility to Vogt-Koyanagi-Harada Syndrome in a Han Chinese Population

Exogenous zinc ions interrupt visual signal transmission from photoreceptors to bipolar cells and reduce retinal TRPM1 expression in mouse

Angiotensin-Converting Enzyme 2 (ACE2) Activator DIZE Ameliorates Endotoxin-Induced Uveitis in Mice

Decreased IL-27 Expression in Association with an Increased Th17 Response in Vogt-Koyanagi-Harada Disease

The Characteristics Of Cone-driven Oscillatory Potentials In Human Electroretinogram

Electroretinogram and Fundus Changes in the Progress of Choroidal Osteoma

Hyperglycemia Induced Methylation Changes In Genes Of Ocular Renin Angiotensin System

CD4+ T Cells In Vogt-koyanagi-harada Disease Show A Decreased Stimulation Of IL-27 Expression By Dendritic Cells

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