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ARVO Annual Meeting Abstract June 2022

Novel association to retinal homeostasis identified for a gene involved in ubiquitination and proteasomal degradation.

Yeshumenesh Zegeye; Bogale Aredo; Seher Yuksel; Cynthia X. Zhao; Sara Ludwig; Miao Tang; Xiaohong Li; Bruce A. Beutler; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1963 – F0381. doi:

ARVO Annual Meeting Abstract June 2022

Deletion of a cholesteryl ester hydrolase leads to a progressive retinal degeneration in mice

Seher Yuksel; Bogale Aredo; Yeshumenesh Zegeye; Cynthia X. Zhao; Miao Tang; Xiaohong Li; Laurent Gautron; Sara Ludwig; Igor A Butovich; Bruce A. Beutler; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1952 – F0370. doi:

ARVO Annual Meeting Abstract June 2022

Differential response of Muller cells to retinal injury in the fundus camera-delivered light induced retinal degeneration (FCD-LIRD) model

Bogale Aredo; Bo Chen; Yi Ding; Cynthia X. Zhao; Ashwani Kumar; Chao Xing; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1367 – F0298. doi:

ARVO Annual Meeting Abstract June 2021

Analysis of cell type-specific responses to retinal injury in the fundus camera delivered-light induced retinal degeneration (FCD-LIRD) model

Bogale Aredo; Bo Chen; Yi Ding; Cynthia Zhao; Ashwani Kumar; Chao Xing; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3120. doi:

ARVO Annual Meeting Abstract June 2020

Forward genetic analysis combined with OCT and fundus photography identifies mutations leading to progressive outer retinal degeneration in C57BL/6J mice

Bogale Aredo; Bo Chen; Yi Ding; Yuanfei Zhu; Cynthia Zhao; Ashwani Kumar; Chao Xing; Stephen Lyon; Jamie Russell; Xiaohong Li; Miao Tang; Priscilla Anderton; Sara Ludwig; Eva Marie Moresco; Bruce Beutler; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1896. doi:

Retinal Cell Biology September 2019

Mice With a Combined Deficiency of Superoxide Dismutase 1 ( Sod1 ), DJ-1 ( Park7 ), and Parkin ( Prkn ) Develop Spontaneous Retinal Degeneration With Aging

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Yuanfei Zhu; Bogale Aredo; Bo Chen; Cynthia X. Zhao; Yu-Guang He; Rafael L. Ufret-Vincenty
TAGS: aging, mice, parkinson disease 7, autosomal recessive early-onset, retinal degeneration, park2 gene, sod1 gene, retina, superoxide dismutase 1
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3740-3751. doi: https://doi.org/10.1167/iovs.19-27212

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Mice with a combined deficiency of SOD1, DJ-1 and Parkin develop spontaneous retinal degeneration with aging

Bogale Aredo; Bo Chen; Yuanfei Zhu; Cynthia X Zhao; Yu_Guang He; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4915. doi:

ARVO Annual Meeting Abstract July 2019

Forward genetics: searching for novel genes essential to retinal development and homeostasis

Rafael Ufret-Vincenty; Bogale Aredo; Bo Chen; Yuanfei Zhu; Yi Ding; Cynthia X Zhao; Bruce Beutler

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6060. doi:

Retina March 2019

A Mouse Model of Retinal Recovery From Photo-Oxidative/Photo-Inflammatory Injury: Nrf2, SOD1, DJ-1, and Parkin Are Not Essential to Recovery

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Bo Chen; Bogale Aredo; Yuanfei Zhu; Yi Ding; Cynthia Xin-Zhao; Rafael L. Ufret-Vincenty
TAGS: mice, oxidative stress, park2 gene, recovery of function, sod1 gene, wounds and injuries, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1165-1174. doi: https://doi.org/10.1167/iovs.18-25751

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Forward genetics: searching for novel genes essential to retinal development and function

Bogale Aredo; Yi Ding; Xin Zhong; Cynthia Xin-Zhao Wang; Bruce Beutler; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1841. doi:

ARVO Annual Meeting Abstract June 2017

The fundus camera delivered-light induced retinal degeneration model is mediated by oxidative stress

Cynthia Xin-Zhao Wang; Bogale Aredo; Yi Ding; Xin Zhong; Kaiyan Zhang; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5362. doi:

Retina October 2016

Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis

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Xin Zhong; Bogale Aredo; Yi Ding; Kaiyan Zhang; Cynthia X. Zhao; Rafael L. Ufret-Vincenty
TAGS: apoptosis, fluorescein, mice, oxidative stress, retinal degeneration, wounds and injuries, eye, retina
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5558-5567. doi: https://doi.org/10.1167/iovs.16-19965

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

A forward genetics approach to discovering novel genes essential to retinal development and function

Yi Ding; Xin Zhong; Bogale Aredo; Cynthia Xin-Zhao Wang; Bruce Beutler; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2636. doi:

ARVO Annual Meeting Abstract September 2016

Development of a new model of retinal light injury in pigmented mice

Bogale Aredo; Xin Zhong; Yi Ding; Kaiyan Zhang; Cynthia Xin-Zhao Wang; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5790. doi:

ARVO Annual Meeting Abstract September 2016

Towards an understanding of the molecular basis for subretinal macrophage/microglial infiltration

Cynthia Xin-Zhao Wang; Bogale Aredo; Xin Zhong; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6575. doi:

Retina November 2015

Phosphatidylserine (PS) Is Exposed in Choroidal Neovascular Endothelium: PS-Targeting Antibodies Inhibit Choroidal Angiogenesis In Vivo and Ex Vivo

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Tao Li; Bogale Aredo; Kaiyan Zhang; Xin Zhong; Jose S. Pulido; Shusheng Wang; Yu-Guang He; Xianming Huang; Rolf A. Brekken; Rafael L. Ufret-Vincenty
TAGS: antibodies, choroidal neovascularization, phosphatidylserines, angiogenesis, lasers, endothelium
Invest. Ophthalmol. Vis. Sci.. 2015; 56(12):7137-7145. doi: https://doi.org/10.1167/iovs.15-17302

ARVO Annual Meeting Abstract June 2015

Differential gene expression in mouse eyes with high vs. low subretinal macrophage/microglial infiltration.

Cynthia Xin-Zhao Wang; Bogale Aredo; Tao Li; Rafael Ufret-Vincenty; Bogale Aredo, Tao Li, and Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):423. doi:

ARVO Annual Meeting Abstract June 2015

Phosphatidylserine (PS) is exposed in choroidal neovascular endothelium, and PS-targeting antibodies inhibit choroidal angiogenesis in vivo and ex vivo

Bogale Aredo; Tao Li; Kaiyan Zhang; Jose S Pulido; Shusheng Wang; Philip Thorpe; Rolf Brekken; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2273. doi:

Retina June 2015

A Chimeric Cfh Transgene Leads to Increased Retinal Oxidative Stress, Inflammation, and Accumulation of Activated Subretinal Microglia in Mice

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Bogale Aredo; Tao Li; Xiao Chen; Kaiyan Zhang; Cynthia Xin-Zhao Wang; Darlene Gou; Biren Zhao; Yuguang He; Rafael L. Ufret-Vincenty
TAGS: mice, oxidative stress, inflammation, microglia, retina, chimera organism, transgenes
Invest. Ophthalmol. Vis. Sci.. 2015; 56(6):3427-3440. doi: https://doi.org/10.1167/iovs.14-16089

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Increased expression of inflammatory markers in the RPE of CfhTg mice and in RD8+/+ mice.

Cynthia Xin-Zhao Wang; Bogale Aredo; Tao Li; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3280. doi:

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Novel association to retinal homeostasis identified for a gene involved in ubiquitination and proteasomal degradation.

Deletion of a cholesteryl ester hydrolase leads to a progressive retinal degeneration in mice

Differential response of Muller cells to retinal injury in the fundus camera-delivered light induced retinal degeneration (FCD-LIRD) model

Analysis of cell type-specific responses to retinal injury in the fundus camera delivered-light induced retinal degeneration (FCD-LIRD) model

Forward genetic analysis combined with OCT and fundus photography identifies mutations leading to progressive outer retinal degeneration in C57BL/6J mice

Mice With a Combined Deficiency of Superoxide Dismutase 1 ( Sod1 ), DJ-1 ( Park7 ), and Parkin ( Prkn ) Develop Spontaneous Retinal Degeneration With Aging

Mice with a combined deficiency of SOD1, DJ-1 and Parkin develop spontaneous retinal degeneration with aging

Forward genetics: searching for novel genes essential to retinal development and homeostasis

A Mouse Model of Retinal Recovery From Photo-Oxidative/Photo-Inflammatory Injury: Nrf2, SOD1, DJ-1, and Parkin Are Not Essential to Recovery

Forward genetics: searching for novel genes essential to retinal development and function

The fundus camera delivered-light induced retinal degeneration model is mediated by oxidative stress

Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis

A forward genetics approach to discovering novel genes essential to retinal development and function

Development of a new model of retinal light injury in pigmented mice

Towards an understanding of the molecular basis for subretinal macrophage/microglial infiltration

Phosphatidylserine (PS) Is Exposed in Choroidal Neovascular Endothelium: PS-Targeting Antibodies Inhibit Choroidal Angiogenesis In Vivo and Ex Vivo

Differential gene expression in mouse eyes with high vs. low subretinal macrophage/microglial infiltration.

Phosphatidylserine (PS) is exposed in choroidal neovascular endothelium, and PS-targeting antibodies inhibit choroidal angiogenesis in vivo and ex vivo

A Chimeric Cfh Transgene Leads to Increased Retinal Oxidative Stress, Inflammation, and Accumulation of Activated Subretinal Microglia in Mice

Increased expression of inflammatory markers in the RPE of CfhTg mice and in RD8+/+ mice.

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